Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fdpeP26_F_M19
(1176 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
U24253-1|AAC13871.1| 353|Homo sapiens folylpolyglutamate synthe... 260 9e-69
M98045-1|AAA35852.1| 545|Homo sapiens folylpolyglutamate synthe... 260 9e-69
BC064393-1|AAH64393.1| 587|Homo sapiens folylpolyglutamate synt... 260 9e-69
AL162586-11|CAI39770.1| 587|Homo sapiens folylpolyglutamate syn... 260 9e-69
AL162586-14|CAI39773.1| 537|Homo sapiens folylpolyglutamate syn... 252 2e-66
AL162586-10|CAI39769.1| 375|Homo sapiens folylpolyglutamate syn... 250 6e-66
AL162586-13|CAI39772.1| 265|Homo sapiens folylpolyglutamate syn... 242 1e-63
U40868-1|AAA87568.1| 486|Homo sapiens folylpolyglutamate synthe... 209 2e-53
AL162586-12|CAI39771.1| 194|Homo sapiens folylpolyglutamate syn... 196 1e-49
BT006639-1|AAP35285.1| 174|Homo sapiens folylpolyglutamate synt... 91 7e-18
U14939-1|AAA85815.1| 107|Homo sapiens folylpolyglutamate synthe... 66 3e-10
AY007211-2|AAL08406.1| 53|Homo sapiens folylpolyglutamate synt... 33 2.0
AY007211-1|AAL08407.1| 75|Homo sapiens folylpolyglutamate synt... 33 2.0
>U24253-1|AAC13871.1| 353|Homo sapiens folylpolyglutamate synthetase
protein.
Length = 353
Score = 260 bits (636), Expect = 9e-69
Identities = 125/239 (52%), Positives = 172/239 (71%), Gaps = 1/239 (0%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVA 491
Y+ AVR LN LQ+N +EQ+++ + G T LE ME YL+R+G+ + LD L+++HV
Sbjct: 45 YQDAVRMLNTLQTNAGYLEQVKR--QRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVT 102
Query: 492 GTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQR 671
GTKGKGST A E ILR +G +TGF+SSPHLV VRER+R+NG+ IS ++F KYF ++ R
Sbjct: 103 GTKGKGSTCAFTECILRSYGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHR 162
Query: 672 LEDTQKFEG-DMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGIT 848
LE+T+ MP YF FLT+MA+++FL+EKVD+A+VEVGIGG D TNI+RK V G++
Sbjct: 163 LEETKDGSCVSMPPYFRFLTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVS 222
Query: 849 ALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPLTXVP 1025
+LG+DHTS+LG+T+++IA K GI K+G A+TV QP + VL A + CPL P
Sbjct: 223 SLGIDHTSLLGDTVEKIAWQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCP 281
>M98045-1|AAA35852.1| 545|Homo sapiens folylpolyglutamate synthetase
protein.
Length = 545
Score = 260 bits (636), Expect = 9e-69
Identities = 125/239 (52%), Positives = 172/239 (71%), Gaps = 1/239 (0%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVA 491
Y+ AVR LN LQ+N +EQ+++ + G T LE ME YL+R+G+ + LD L+++HV
Sbjct: 3 YQDAVRMLNTLQTNAGYLEQVKR--QRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVT 60
Query: 492 GTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQR 671
GTKGKGST A E ILR +G +TGF+SSPHLV VRER+R+NG+ IS ++F KYF ++ R
Sbjct: 61 GTKGKGSTCAFTECILRSYGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHR 120
Query: 672 LEDTQKFEG-DMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGIT 848
LE+T+ MP YF FLT+MA+++FL+EKVD+A+VEVGIGG D TNI+RK V G++
Sbjct: 121 LEETKDGSCVSMPPYFRFLTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVS 180
Query: 849 ALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPLTXVP 1025
+LG+DHTS+LG+T+++IA K GI K+G A+TV QP + VL A + CPL P
Sbjct: 181 SLGIDHTSLLGDTVEKIAWQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCP 239
>BC064393-1|AAH64393.1| 587|Homo sapiens folylpolyglutamate synthase
protein.
Length = 587
Score = 260 bits (636), Expect = 9e-69
Identities = 125/239 (52%), Positives = 172/239 (71%), Gaps = 1/239 (0%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVA 491
Y+ AVR LN LQ+N +EQ+++ + G T LE ME YL+R+G+ + LD L+++HV
Sbjct: 45 YQDAVRMLNTLQTNAGYLEQVKR--QRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVT 102
Query: 492 GTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQR 671
GTKGKGST A E ILR +G +TGF+SSPHLV VRER+R+NG+ IS ++F KYF ++ R
Sbjct: 103 GTKGKGSTCAFTECILRSYGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHR 162
Query: 672 LEDTQKFEG-DMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGIT 848
LE+T+ MP YF FLT+MA+++FL+EKVD+A+VEVGIGG D TNI+RK V G++
Sbjct: 163 LEETKDGSCVSMPPYFRFLTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVS 222
Query: 849 ALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPLTXVP 1025
+LG+DHTS+LG+T+++IA K GI K+G A+TV QP + VL A + CPL P
Sbjct: 223 SLGIDHTSLLGDTVEKIAWQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCP 281
>AL162586-11|CAI39770.1| 587|Homo sapiens folylpolyglutamate synthase
protein.
Length = 587
Score = 260 bits (636), Expect = 9e-69
Identities = 125/239 (52%), Positives = 172/239 (71%), Gaps = 1/239 (0%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVA 491
Y+ AVR LN LQ+N +EQ+++ + G T LE ME YL+R+G+ + LD L+++HV
Sbjct: 45 YQDAVRMLNTLQTNAGYLEQVKR--QRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVT 102
Query: 492 GTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQR 671
GTKGKGST A E ILR +G +TGF+SSPHLV VRER+R+NG+ IS ++F KYF ++ R
Sbjct: 103 GTKGKGSTCAFTECILRSYGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHR 162
Query: 672 LEDTQKFEG-DMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGIT 848
LE+T+ MP YF FLT+MA+++FL+EKVD+A+VEVGIGG D TNI+RK V G++
Sbjct: 163 LEETKDGSCVSMPPYFRFLTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVS 222
Query: 849 ALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPLTXVP 1025
+LG+DHTS+LG+T+++IA K GI K+G A+TV QP + VL A + CPL P
Sbjct: 223 SLGIDHTSLLGDTVEKIAWQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCP 281
>AL162586-14|CAI39773.1| 537|Homo sapiens folylpolyglutamate synthase
protein.
Length = 537
Score = 252 bits (616), Expect = 2e-66
Identities = 121/232 (52%), Positives = 167/232 (71%), Gaps = 1/232 (0%)
Frame = +3
Query: 333 LNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGS 512
LN LQ+N +EQ+++ + G T LE ME YL+R+G+ + LD L+++HV GTKGKGS
Sbjct: 2 LNTLQTNAGYLEQVKR--QRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGS 59
Query: 513 TSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKF 692
T A E ILR +G +TGF+SSPHLV VRER+R+NG+ IS ++F KYF ++ RLE+T+
Sbjct: 60 TCAFTECILRSYGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDG 119
Query: 693 EG-DMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHT 869
MP YF FLT+MA+++FL+EKVD+A+VEVGIGG D TNI+RK V G+++LG+DHT
Sbjct: 120 SCVSMPPYFRFLTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHT 179
Query: 870 SILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPLTXVP 1025
S+LG+T+++IA K GI K+G A+TV QP + VL A + CPL P
Sbjct: 180 SLLGDTVEKIAWQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCP 231
>AL162586-10|CAI39769.1| 375|Homo sapiens folylpolyglutamate synthase
protein.
Length = 375
Score = 250 bits (613), Expect = 6e-66
Identities = 121/231 (52%), Positives = 168/231 (72%), Gaps = 1/231 (0%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVA 491
Y+ AVR LN LQ+N +EQ+++ + G T LE ME YL+R+G+ + LD L+++HV
Sbjct: 45 YQDAVRMLNTLQTNAGYLEQVKR--QRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVT 102
Query: 492 GTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQR 671
GTKGKGST A E ILR +G +TGF+SSPHLV VRER+R+NG+ IS ++F KYF ++ R
Sbjct: 103 GTKGKGSTCAFTECILRSYGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHR 162
Query: 672 LEDTQKFE-GDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGIT 848
LE+T+ MP YF FLT+MA+++FL+EKVD+A+VEVGIGG D TNI+RK V G++
Sbjct: 163 LEETKDGSCVSMPPYFRFLTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVS 222
Query: 849 ALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSL 1001
+LG+DHTS+LG+T+++IA K GI K+G A+TV QP + VL A +
Sbjct: 223 SLGIDHTSLLGDTVEKIAWQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQI 273
>AL162586-13|CAI39772.1| 265|Homo sapiens folylpolyglutamate synthase
protein.
Length = 265
Score = 242 bits (593), Expect = 1e-63
Identities = 117/224 (52%), Positives = 163/224 (72%), Gaps = 1/224 (0%)
Frame = +3
Query: 333 LNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGS 512
LN LQ+N +EQ+++ + G T LE ME YL+R+G+ + LD L+++HV GTKGKGS
Sbjct: 2 LNTLQTNAGYLEQVKR--QRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGS 59
Query: 513 TSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKF 692
T A E ILR +G +TGF+SSPHLV VRER+R+NG+ IS ++F KYF ++ RLE+T+
Sbjct: 60 TCAFTECILRSYGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDG 119
Query: 693 E-GDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHT 869
MP YF FLT+MA+++FL+EKVD+A+VEVGIGG D TNI+RK V G+++LG+DHT
Sbjct: 120 SCVSMPPYFRFLTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHT 179
Query: 870 SILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSL 1001
S+LG+T+++IA K GI K+G A+TV QP + VL A +
Sbjct: 180 SLLGDTVEKIAWQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQI 223
>U40868-1|AAA87568.1| 486|Homo sapiens folylpolyglutamate synthetase
protein.
Length = 486
Score = 209 bits (510), Expect = 2e-53
Identities = 99/179 (55%), Positives = 132/179 (73%), Gaps = 1/179 (0%)
Frame = +3
Query: 492 GTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQR 671
GTKGKGST A E ILR +G +TGF+SSPHLV VRER+R+NG+ IS ++F KYF ++ R
Sbjct: 2 GTKGKGSTCAFTECILRSYGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHR 61
Query: 672 LEDTQKFEG-DMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGIT 848
LE+T+ MP YF FLT+MA+++FL+EKVD+A+VEVGIGG D TNI+RK V G++
Sbjct: 62 LEETKDGSCVSMPPYFRFLTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVS 121
Query: 849 ALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPLTXVP 1025
+LG+DHTS+LG+T+++IA K GI K+G A+TV QP + VL A + CPL P
Sbjct: 122 SLGIDHTSLLGDTVEKIAWQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCP 180
>AL162586-12|CAI39771.1| 194|Homo sapiens folylpolyglutamate
synthase protein.
Length = 194
Score = 196 bits (479), Expect = 1e-49
Identities = 104/216 (48%), Positives = 143/216 (66%)
Frame = +3
Query: 333 LNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGS 512
LN LQ+N +EQ+++ + G T LE ME YL+R+G+ + LD L+++HV GTKGKGS
Sbjct: 2 LNTLQTNAGYLEQVKR--QRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGS 59
Query: 513 TSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKF 692
T A E ILR +G +TGF+SSPHLV VRER+R+NG+ IS ++F KYF ++ RLE+T
Sbjct: 60 TCAFTECILRSYGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEET--- 116
Query: 693 EGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTS 872
KVD+A+VEVGIGG D TNI+RK V G+++LG+DHTS
Sbjct: 117 ----------------------KVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTS 154
Query: 873 ILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVL 980
+LG+T+++IA K GI K+G A+TV QP + VL
Sbjct: 155 LLGDTVEKIAWQKGGIFKQGVPAFTVLQPEGPLAVL 190
>BT006639-1|AAP35285.1| 174|Homo sapiens folylpolyglutamate
synthase protein.
Length = 174
Score = 91.1 bits (216), Expect = 7e-18
Identities = 43/86 (50%), Positives = 60/86 (69%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVA 491
Y+ AVR LN LQ+N +EQ+++ + G T LE ME YL+R+G+ + LD L+++HV
Sbjct: 45 YQDAVRMLNTLQTNAGYLEQVKR--QRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVT 102
Query: 492 GTKGKGSTSAMCESILRHHGFRTGFY 569
GTKGKGST A E ILR +G +TGF+
Sbjct: 103 GTKGKGSTCAFTECILRSYGLKTGFF 128
>U14939-1|AAA85815.1| 107|Homo sapiens folylpolyglutamate
synthetase protein.
Length = 107
Score = 65.7 bits (153), Expect = 3e-10
Identities = 31/65 (47%), Positives = 45/65 (69%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVA 491
Y+ AVR LN LQ+N +EQ+++ + G T LE ME YL+R+G+ + LD L+++HV
Sbjct: 45 YQDAVRMLNTLQTNAGYLEQVKR--QRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVT 102
Query: 492 GTKGK 506
GTKGK
Sbjct: 103 GTKGK 107
>AY007211-2|AAL08406.1| 53|Homo sapiens folylpolyglutamate
synthetase cytosolic isoform protein.
Length = 53
Score = 33.1 bits (72), Expect = 2.0
Identities = 17/40 (42%), Positives = 25/40 (62%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENY 431
++ AVR LN LQ+N +EQ+++ + G T LE ME Y
Sbjct: 16 FQDAVRMLNTLQTNAGYLEQVKR--QRGDPQTQLEAMELY 53
>AY007211-1|AAL08407.1| 75|Homo sapiens folylpolyglutamate
synthetase mitochondrial isoform protein.
Length = 75
Score = 33.1 bits (72), Expect = 2.0
Identities = 17/40 (42%), Positives = 25/40 (62%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENY 431
++ AVR LN LQ+N +EQ+++ + G T LE ME Y
Sbjct: 38 FQDAVRMLNTLQTNAGYLEQVKR--QRGDPQTQLEAMELY 75
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 140,320,692
Number of Sequences: 237096
Number of extensions: 2831846
Number of successful extensions: 9180
Number of sequences better than 10.0: 13
Number of HSP's better than 10.0 without gapping: 8924
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 9162
length of database: 76,859,062
effective HSP length: 92
effective length of database: 55,046,230
effective search space used: 16458822770
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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