Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fdpeP26_F_B06
(1192 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P48596 Cluster: GTP cyclohydrolase I; n=6; cellular org... 370 e-101
UniRef50_P30793 Cluster: GTP cyclohydrolase I; n=78; cellular or... 250 7e-65
UniRef50_Q19980 Cluster: GTP cyclohydrolase I; n=89; cellular or... 246 7e-64
UniRef50_A6QSY1 Cluster: GTP cyclohydrolase I; n=3; cellular org... 225 2e-57
UniRef50_Q94465 Cluster: GTP cyclohydrolase I; n=2; Dictyosteliu... 216 8e-55
UniRef50_Q8YLL1 Cluster: GTP cyclohydrolase I 1; n=29; Bacteria|... 214 3e-54
UniRef50_P51599 Cluster: GTP cyclohydrolase I; n=14; Ascomycota|... 211 2e-53
UniRef50_Q8KEA8 Cluster: GTP cyclohydrolase I; n=46; Bacteria|Re... 209 9e-53
UniRef50_Q6F9M5 Cluster: GTP cyclohydrolase I; n=3; cellular org... 198 2e-49
UniRef50_Q4SEZ7 Cluster: Chromosome 1 SCAF14609, whole genome sh... 195 2e-48
UniRef50_Q9RYB4 Cluster: GTP cyclohydrolase I; n=5; Bacteria|Rep... 194 5e-48
UniRef50_Q2GYY2 Cluster: Putative uncharacterized protein; n=1; ... 185 2e-45
UniRef50_A5UR68 Cluster: GTP cyclohydrolase I; n=7; Bacteria|Rep... 184 5e-45
UniRef50_A5WE14 Cluster: GTP cyclohydrolase I; n=4; Pseudomonada... 181 3e-44
UniRef50_Q8G0L4 Cluster: GTP cyclohydrolase I; n=20; Bacteria|Re... 166 1e-39
UniRef50_Q2Q448 Cluster: GTP cyclohydrolase I; n=1; Toxoplasma g... 163 6e-39
UniRef50_Q3WEZ6 Cluster: GTP cyclohydrolase I; n=7; Bacteria|Rep... 162 2e-38
UniRef50_Q8G3S1 Cluster: GTP cyclohydrolase I; n=4; Bifidobacter... 158 3e-37
UniRef50_Q92QB4 Cluster: GTP cyclohydrolase I; n=49; Proteobacte... 157 5e-37
UniRef50_P0C0C1 Cluster: GTP cyclohydrolase I; n=23; Bacteria|Re... 154 4e-36
UniRef50_Q68WZ4 Cluster: GTP cyclohydrolase 1; n=25; Bacteria|Re... 153 9e-36
UniRef50_O69531 Cluster: GTP cyclohydrolase I; n=98; Bacteria|Re... 153 9e-36
UniRef50_A6SZ52 Cluster: GTP cyclohydrolase I; n=2; root|Rep: GT... 153 1e-35
UniRef50_A5EFZ1 Cluster: GTP cyclohydrolase I; n=6; Proteobacter... 151 5e-35
UniRef50_Q6NF93 Cluster: GTP cyclohydrolase I; n=8; Bacteria|Rep... 150 6e-35
UniRef50_A2U8J6 Cluster: GTP cyclohydrolase I; n=2; Bacillus|Rep... 150 6e-35
UniRef50_Q89IW2 Cluster: GTP cyclohydrolase I; n=13; Bacteria|Re... 149 1e-34
UniRef50_Q5NN57 Cluster: GTP cyclohydrolase I; n=4; Sphingomonad... 149 1e-34
UniRef50_Q9PC02 Cluster: GTP cyclohydrolase I; n=16; Bacteria|Re... 149 2e-34
UniRef50_A4G565 Cluster: GTP cyclohydrolase I; n=2; Betaproteoba... 148 2e-34
UniRef50_Q0CVT9 Cluster: GTP cyclohydrolase I; n=1; Aspergillus ... 147 6e-34
UniRef50_A2BL58 Cluster: GTP cyclohydrolase I; n=2; Thermoprotei... 147 6e-34
UniRef50_Q7VFG4 Cluster: GTP cyclohydrolase I; n=6; Helicobacter... 144 4e-33
UniRef50_UPI0000DADB56 Cluster: hypothetical protein RcanM_01000... 144 5e-33
UniRef50_Q1IAJ6 Cluster: Putative GTP cyclohydrolase I; n=1; Pse... 143 9e-33
UniRef50_A4QTK3 Cluster: Putative uncharacterized protein; n=1; ... 140 5e-32
UniRef50_A7QSC6 Cluster: Chromosome chr3 scaffold_158, whole gen... 138 3e-31
UniRef50_A0RYT5 Cluster: GTP cyclohydrolase I; n=2; Thermoprotei... 137 5e-31
UniRef50_Q82Z12 Cluster: GTP cyclohydrolase I; n=1; Enterococcus... 135 2e-30
UniRef50_Q88ST4 Cluster: GTP cyclohydrolase I; n=11; Lactobacill... 130 9e-29
UniRef50_Q97D54 Cluster: GTP cyclohydrolase I; n=7; Clostridium|... 129 2e-28
UniRef50_A5Z385 Cluster: Putative uncharacterized protein; n=1; ... 123 8e-27
UniRef50_A1SM21 Cluster: GTP cyclohydrolase I precursor; n=7; Ac... 121 4e-26
UniRef50_Q8S3C2 Cluster: GTP cyclohydrolase I; n=7; core eudicot... 120 6e-26
UniRef50_Q2GK14 Cluster: GTP cyclohydrolase I; n=2; Anaplasma ph... 120 1e-25
UniRef50_Q971G9 Cluster: GTP cyclohydrolase I; n=4; Sulfolobacea... 120 1e-25
UniRef50_Q8RH43 Cluster: GTP cyclohydrolase I; n=3; Fusobacteriu... 118 2e-25
UniRef50_Q01A10 Cluster: GTP cyclohydrolase I; n=2; Ostreococcus... 118 3e-25
UniRef50_Q2JC68 Cluster: GTP cyclohydrolase I; n=1; Frankia sp. ... 117 7e-25
UniRef50_Q1Q0A8 Cluster: Strongly similar to GTP cyclohydrolase ... 117 7e-25
UniRef50_Q8T649 Cluster: GTP cyclohydrolase I; n=3; Plasmodium y... 116 2e-24
UniRef50_Q5HBC9 Cluster: GTP cyclohydrolase I; n=4; canis group|... 114 5e-24
UniRef50_Q6SIF0 Cluster: GTP cyclohydrolase I; n=1; Plasmodium k... 114 5e-24
UniRef50_Q5PAR5 Cluster: GTP cyclohydrolase; n=1; Anaplasma marg... 113 6e-24
UniRef50_Q1FI35 Cluster: GTP cyclohydrolase I; n=1; Clostridium ... 111 3e-23
UniRef50_O97071 Cluster: GTP cyclohydrolase I; n=6; Plasmodium|R... 111 3e-23
UniRef50_A4CGT7 Cluster: GTP cyclohydrolase I; n=1; Robiginitale... 111 5e-23
UniRef50_A5K040 Cluster: GTP cyclohydrolase I, putative; n=1; Pl... 109 2e-22
UniRef50_A6RNT4 Cluster: Putative uncharacterized protein; n=2; ... 107 4e-22
UniRef50_Q5V5Y0 Cluster: GTP cyclohydrolase I; n=1; Haloarcula m... 107 4e-22
UniRef50_Q6MK87 Cluster: FolE protein; n=1; Bdellovibrio bacteri... 107 7e-22
UniRef50_Q23AG3 Cluster: GTP cyclohydrolase I family protein; n=... 106 1e-21
UniRef50_UPI00015BB290 Cluster: GTP cyclohydrolase; n=1; Ignicoc... 101 4e-20
UniRef50_Q8ZG15 Cluster: GTP cyclohydrolase I; n=129; root|Rep: ... 101 5e-20
UniRef50_Q19Z80 Cluster: Gp6; n=4; root|Rep: Gp6 - Mycobacterium... 100 6e-20
UniRef50_Q8ZWW5 Cluster: GTP cyclohydrolase I; n=4; Pyrobaculum|... 100 6e-20
UniRef50_Q7XM20 Cluster: OSJNBa0084K01.11 protein; n=4; Oryza sa... 99 1e-19
UniRef50_Q6ME26 Cluster: Probable GTP cyclohydrolase I; n=1; Can... 97 8e-19
UniRef50_A3J0S0 Cluster: GTP cyclohydrolase I; n=28; Bacteroidet... 97 8e-19
UniRef50_Q54768 Cluster: Putative uncharacterized protein; n=1; ... 97 1e-18
UniRef50_UPI000038E307 Cluster: hypothetical protein Faci_030017... 94 7e-18
UniRef50_Q7N3C4 Cluster: Similarities with GTP cyclohydrolase I;... 85 3e-15
UniRef50_Q2GDH9 Cluster: GTP cyclohydrolase I; n=1; Neorickettsi... 84 8e-15
UniRef50_Q08SR8 Cluster: GTP cyclohydrolase I 2; n=2; Cystobacte... 83 1e-14
UniRef50_Q8XZK8 Cluster: GTP cyclohydrolase I; n=29; Betaproteob... 83 1e-14
UniRef50_A7HBJ5 Cluster: GTP cyclohydrolase I; n=2; Anaeromyxoba... 83 2e-14
UniRef50_A4SVK2 Cluster: GTP cyclohydrolase I; n=20; Bacteria|Re... 80 1e-13
UniRef50_A5GUC6 Cluster: GTP cyclohydrolase I; n=28; Cyanobacter... 80 1e-13
UniRef50_A7JLM6 Cluster: GTP cyclohydrolase I; n=11; Francisella... 79 2e-13
UniRef50_Q83FV8 Cluster: GTP cyclohydrolase I; n=2; Tropheryma w... 77 1e-12
UniRef50_UPI0000F1DBDC Cluster: PREDICTED: similar to GTP cycloh... 66 2e-09
UniRef50_A0YW77 Cluster: GTP cyclohydrolase I; n=1; Lyngbya sp. ... 39 0.22
UniRef50_Q9WZP8 Cluster: NADPH-dependent 7-cyano-7-deazaguanine ... 38 0.39
UniRef50_Q7NR63 Cluster: Acetylglutamate kinase; n=3; Bacteria|R... 38 0.39
UniRef50_A6GIP6 Cluster: Putative uncharacterized protein; n=1; ... 36 1.6
UniRef50_Q5AW97 Cluster: Putative uncharacterized protein; n=1; ... 35 4.8
UniRef50_Q4EE10 Cluster: GTP cyclohydrolase I; n=1; Listeria mon... 34 6.3
UniRef50_A6RXW6 Cluster: Putative uncharacterized protein; n=1; ... 34 6.3
UniRef50_Q5FLA3 Cluster: Negative regulator genetic competence; ... 34 8.3
>UniRef50_P48596 Cluster: GTP cyclohydrolase I; n=6; cellular
organisms|Rep: GTP cyclohydrolase I - Drosophila
melanogaster (Fruit fly)
Length = 324
Score = 370 bits (910), Expect = e-101
Identities = 175/210 (83%), Positives = 190/210 (90%)
Frame = +2
Query: 344 PEALKXFNLADAESELEVPGTPMTPRTSTTPGHENCTFHHDLELDHRPPTREALLPDMAN 523
P + N + +S+ P TP+TPRTSTTPGHE CTFHHDLELDH+PPTREALLPDMA
Sbjct: 87 PRLILKTNGSSPDSDGTQPKTPLTPRTSTTPGHEKCTFHHDLELDHKPPTREALLPDMAR 146
Query: 524 SYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVK 703
SYRLLL GLGE+P+R GL+KTPERAAKAML+FTKGYDQSLE+VLN A+FDED DEMVVVK
Sbjct: 147 SYRLLLGGLGENPDRQGLIKTPERAAKAMLYFTKGYDQSLEDVLNGAVFDEDHDEMVVVK 206
Query: 704 DIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAV 883
DIEMFSMCEHHLVPFYGKVSIGYLP KILGLSKLARIVEIFSRRLQVQERLTKQIA+AV
Sbjct: 207 DIEMFSMCEHHLVPFYGKVSIGYLPCNKILGLSKLARIVEIFSRRLQVQERLTKQIAVAV 266
Query: 884 TQAVRPAGVAVVIEGVHMCMVMRGVQKINS 973
TQAV+PAGVAVV+EGVHMCMVMRGVQKINS
Sbjct: 267 TQAVQPAGVAVVVEGVHMCMVMRGVQKINS 296
>UniRef50_P30793 Cluster: GTP cyclohydrolase I; n=78; cellular
organisms|Rep: GTP cyclohydrolase I - Homo sapiens
(Human)
Length = 250
Score = 250 bits (611), Expect = 7e-65
Identities = 116/159 (72%), Positives = 139/159 (87%)
Frame = +2
Query: 497 EALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDE 676
E LP++A +Y +L+ LGE+P+R GLLKTP RAA AM FFTKGY +++ +VLN+AIFDE
Sbjct: 65 ELNLPNLAAAYSSILSSLGENPQRQGLLKTPWRAASAMQFFTKGYQETISDVLNDAIFDE 124
Query: 677 DTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQER 856
D DEMV+VKDI+MFSMCEHHLVPF GKV IGYLP ++LGLSKLARIVEI+SRRLQVQER
Sbjct: 125 DHDEMVIVKDIDMFSMCEHHLVPFVGKVHIGYLPNKQVLGLSKLARIVEIYSRRLQVQER 184
Query: 857 LTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINS 973
LTKQIA+A+T+A+RPAGV VV+E HMCMVMRGVQK+NS
Sbjct: 185 LTKQIAVAITEALRPAGVGVVVEATHMCMVMRGVQKMNS 223
>UniRef50_Q19980 Cluster: GTP cyclohydrolase I; n=89; cellular
organisms|Rep: GTP cyclohydrolase I - Caenorhabditis
elegans
Length = 223
Score = 246 bits (603), Expect = 7e-64
Identities = 117/160 (73%), Positives = 136/160 (85%)
Frame = +2
Query: 494 REALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFD 673
+E L M N+Y+ ++ +GED R GLLKTPERAAKAM+ FTKGYD L+E+LN A+FD
Sbjct: 36 KEDHLKSMCNAYQSIIQHVGEDINRQGLLKTPERAAKAMMAFTKGYDDQLDELLNEAVFD 95
Query: 674 EDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQE 853
ED DEMV+VKDIEMFS+CEHHLVPF GKV IGY+P K+LGLSKLARIVE+FSRRLQVQE
Sbjct: 96 EDHDEMVIVKDIEMFSLCEHHLVPFMGKVHIGYIPNKKVLGLSKLARIVEMFSRRLQVQE 155
Query: 854 RLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINS 973
RLTKQIA A+ QAV+P+GVAVVIE HMCMVMRGVQKIN+
Sbjct: 156 RLTKQIATAMVQAVQPSGVAVVIEASHMCMVMRGVQKINA 195
>UniRef50_A6QSY1 Cluster: GTP cyclohydrolase I; n=3; cellular
organisms|Rep: GTP cyclohydrolase I - Ajellomyces
capsulatus NAm1
Length = 390
Score = 225 bits (549), Expect = 2e-57
Identities = 100/167 (59%), Positives = 135/167 (80%)
Frame = +2
Query: 473 LDHRPPTREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEV 652
L+ P E +AN+ R +L +GEDPER GLL TPER AKA+++FTKGY++++ ++
Sbjct: 196 LEATPEENEKRTQKLANAVRTVLECIGEDPEREGLLGTPERYAKALMYFTKGYEENVRDL 255
Query: 653 LNNAIFDEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFS 832
+N A+F ED DE+V+VKDIE+FS+CEHHLVPF GK+ IGY+P ++LGLSK AR+ E+FS
Sbjct: 256 VNGAVFHEDHDELVIVKDIEIFSLCEHHLVPFTGKMHIGYIPDRRVLGLSKFARLAEMFS 315
Query: 833 RRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINS 973
RRLQVQERLTKQ+A+A+++ ++P GVAVVIE H+CMVMRGVQK +S
Sbjct: 316 RRLQVQERLTKQVALAISEVLKPRGVAVVIESSHLCMVMRGVQKTSS 362
>UniRef50_Q94465 Cluster: GTP cyclohydrolase I; n=2; Dictyostelium
discoideum|Rep: GTP cyclohydrolase I - Dictyostelium
discoideum (Slime mold)
Length = 232
Score = 216 bits (528), Expect = 8e-55
Identities = 100/154 (64%), Positives = 128/154 (83%)
Frame = +2
Query: 503 LLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDT 682
+L M +S + LL+ LGEDP+R GLLKTP R +KA+LFFT+GY+QS++EV+ AIF+E+
Sbjct: 47 VLNTMQSSVKTLLSSLGEDPDREGLLKTPLRMSKALLFFTQGYEQSVDEVIGEAIFNENH 106
Query: 683 DEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLT 862
EMVVV+DI++FS+CEHH+VPF+GK IGY+P K+LGLSKLAR+ EIF+RRLQVQERLT
Sbjct: 107 HEMVVVRDIDIFSLCEHHMVPFHGKCHIGYIPDQKVLGLSKLARVAEIFARRLQVQERLT 166
Query: 863 KQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQK 964
+QIA A+ + P GVAVVI+ HMCMVMRGVQK
Sbjct: 167 RQIAQAIQAHLNPMGVAVVIDASHMCMVMRGVQK 200
>UniRef50_Q8YLL1 Cluster: GTP cyclohydrolase I 1; n=29;
Bacteria|Rep: GTP cyclohydrolase I 1 - Anabaena sp.
(strain PCC 7120)
Length = 235
Score = 214 bits (523), Expect = 3e-54
Identities = 102/172 (59%), Positives = 130/172 (75%)
Frame = +2
Query: 458 HHDLELDHRPPTREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQ 637
H+ E + P+ E + M + R +L G+GEDPER GLLKTP+R A+AM F T GY+Q
Sbjct: 33 HNGREPELHQPSEEDM-ESMMGAVRSILVGVGEDPEREGLLKTPKRVAEAMRFLTSGYNQ 91
Query: 638 SLEEVLNNAIFDEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARI 817
SLEE+LN A+FDE +EMV+V+DI FS+CEHH++PF G+ + Y+P K++GLSKLARI
Sbjct: 92 SLEELLNGAVFDEGHNEMVLVRDINFFSLCEHHMLPFMGRAHVAYIPNQKVVGLSKLARI 151
Query: 818 VEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINS 973
VE++SRRLQVQERLT+QIA AV + P GVAVV+E HMCMVMRGVQK S
Sbjct: 152 VEMYSRRLQVQERLTRQIAEAVQTILEPQGVAVVMEASHMCMVMRGVQKPGS 203
>UniRef50_P51599 Cluster: GTP cyclohydrolase I; n=14;
Ascomycota|Rep: GTP cyclohydrolase I - Neurospora crassa
Length = 313
Score = 211 bits (516), Expect = 2e-53
Identities = 96/167 (57%), Positives = 127/167 (76%)
Frame = +2
Query: 473 LDHRPPTREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEV 652
L+ ++ L M + R LL +GEDP+R GLL TPER AKAMLF TKGY +++ ++
Sbjct: 118 LEETEAQKQERLDKMKGAVRTLLECIGEDPDREGLLATPERYAKAMLFLTKGYQENVRDI 177
Query: 653 LNNAIFDEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFS 832
+N AIF E +EMV+VKDIE+FSMCEHHLVPF GK+ IGY+P ++G+SKL RI E+F+
Sbjct: 178 VNGAIFQEGHNEMVIVKDIEVFSMCEHHLVPFTGKMHIGYIPSNAVIGISKLPRIAELFA 237
Query: 833 RRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINS 973
RRLQ+QERLTK++A A+ + ++P GVAVV+E H+CMVMRGVQK S
Sbjct: 238 RRLQIQERLTKEVANAIMEILKPQGVAVVMESSHLCMVMRGVQKTTS 284
>UniRef50_Q8KEA8 Cluster: GTP cyclohydrolase I; n=46; Bacteria|Rep:
GTP cyclohydrolase I - Chlorobium tepidum
Length = 224
Score = 209 bits (511), Expect = 9e-53
Identities = 95/159 (59%), Positives = 123/159 (77%)
Frame = +2
Query: 497 EALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDE 676
E +L M ++ LL G+GEDPER GLL TPER AK++ F TKGY Q E++L A+F E
Sbjct: 38 EEVLGSMTDAVYSLLKGVGEDPEREGLLLTPERVAKSLRFLTKGYRQDPEQLLKKAVFTE 97
Query: 677 DTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQER 856
DEMV+VKDI+++SMCEHH++PF+GK + Y+P GKI+GLSK+ R+VE+F+RRLQVQER
Sbjct: 98 SYDEMVLVKDIDIYSMCEHHMLPFFGKAHVAYIPDGKIVGLSKIPRVVEVFARRLQVQER 157
Query: 857 LTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINS 973
LT+QI A+ + P GVAVVIE HMCMVMRGV+K N+
Sbjct: 158 LTQQIRDAIQNVLNPRGVAVVIEATHMCMVMRGVEKQNA 196
>UniRef50_Q6F9M5 Cluster: GTP cyclohydrolase I; n=3; cellular
organisms|Rep: GTP cyclohydrolase I - Acinetobacter sp.
(strain ADP1)
Length = 197
Score = 198 bits (483), Expect = 2e-49
Identities = 94/156 (60%), Positives = 116/156 (74%)
Frame = +2
Query: 506 LPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTD 685
L M SY +LT +GED R GL TP RAAKA F T GY +SLEEV NNA+F D
Sbjct: 13 LMSMQQSYANILTAVGEDLNRPGLKDTPIRAAKAFSFLTSGYGKSLEEVTNNAVFPSDNH 72
Query: 686 EMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTK 865
EMV+VK+IE +S+CEHHL+PFYG+V I YLP+G++LGLSK ARI E+F+RRLQ+QE LT+
Sbjct: 73 EMVLVKNIEFYSLCEHHLLPFYGRVHIAYLPEGQVLGLSKFARITEMFARRLQIQENLTQ 132
Query: 866 QIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINS 973
QIA AV + + GVAV+I+ HMCM+MRGV K S
Sbjct: 133 QIAQAVEEVTKARGVAVMIDSAHMCMMMRGVGKQES 168
>UniRef50_Q4SEZ7 Cluster: Chromosome 1 SCAF14609, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 1
SCAF14609, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 263
Score = 195 bits (475), Expect = 2e-48
Identities = 91/134 (67%), Positives = 113/134 (84%)
Frame = +2
Query: 515 MANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMV 694
M SY+ +LT LGED R GL +TP RAAKAM F TKGY++S++E+LN+AIFDE+ E+V
Sbjct: 39 MEKSYKDILTELGEDATREGLQRTPLRAAKAMQFLTKGYNESVKEILNDAIFDENHQEVV 98
Query: 695 VVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIA 874
+VKDIEMFS+CEHHLVPF+GK I YLP K++GLSKLARIVE++SRR QVQERLTKQIA
Sbjct: 99 IVKDIEMFSLCEHHLVPFFGKAHIAYLPNKKVVGLSKLARIVEVYSRRFQVQERLTKQIA 158
Query: 875 IAVTQAVRPAGVAV 916
A+++A+ PAGVAV
Sbjct: 159 SAISEALEPAGVAV 172
>UniRef50_Q9RYB4 Cluster: GTP cyclohydrolase I; n=5; Bacteria|Rep:
GTP cyclohydrolase I - Deinococcus radiodurans
Length = 216
Score = 194 bits (472), Expect = 5e-48
Identities = 89/167 (53%), Positives = 121/167 (72%), Gaps = 4/167 (2%)
Frame = +2
Query: 485 PPTREALLPDMANSYRLL----LTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEV 652
P + LPD N+ L L +GEDP+R GL +TP+R AKA + T+GY Q+L +V
Sbjct: 18 PSLKGVPLPDNPNNLEPLTREWLAAIGEDPDREGLQRTPQRVAKAWAYMTEGYGQTLAQV 77
Query: 653 LNNAIFDEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFS 832
+ +F + EMV+VKDIE +SMCEHH++PFYG+ + Y+P +ILGLSK ARIV+++S
Sbjct: 78 VGEGVFAAEGSEMVIVKDIEFYSMCEHHMLPFYGRAHVAYIPGTRILGLSKFARIVDLYS 137
Query: 833 RRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINS 973
RRLQVQER+T Q+A AV + + P GVAV++EG+H+CM MRGVQK NS
Sbjct: 138 RRLQVQERITTQVADAVEELLAPKGVAVLMEGIHLCMAMRGVQKQNS 184
>UniRef50_Q2GYY2 Cluster: Putative uncharacterized protein; n=1;
Chaetomium globosum|Rep: Putative uncharacterized
protein - Chaetomium globosum (Soil fungus)
Length = 233
Score = 185 bits (451), Expect = 2e-45
Identities = 86/187 (45%), Positives = 126/187 (67%)
Frame = +2
Query: 386 ELEVPGTPMTPRTSTTPGHENCTFHHDLELDHRPPTREALLPDMANSYRLLLTGLGEDPE 565
E+ P + P + PG T ++ P L + ++ R +L +GE+P+
Sbjct: 52 EMSAPIPVIDPNGLSRPGIGTRT-----RIEESPEQSVKRLGKLGDAVRTMLECIGENPD 106
Query: 566 RAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKDIEMFSMCEHHLVP 745
R G+L TPER AKAM+F T+GY Q++ E++NNAIF E EMV+VKDI++FS+CEHH++P
Sbjct: 107 RPGVLNTPERYAKAMMFLTQGYGQNIHEIVNNAIFHEGHHEMVIVKDIDIFSICEHHMLP 166
Query: 746 FYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIE 925
F GK+ I Y+P ++G+SKL RI E+FSRRLQ+QERLTK +A + + ++P GVAVV+E
Sbjct: 167 FIGKMHIAYIPYHSVIGISKLPRIAEMFSRRLQIQERLTKDVANTIMEVLQPQGVAVVME 226
Query: 926 GVHMCMV 946
H+CM+
Sbjct: 227 ASHLCMI 233
>UniRef50_A5UR68 Cluster: GTP cyclohydrolase I; n=7; Bacteria|Rep:
GTP cyclohydrolase I - Roseiflexus sp. RS-1
Length = 226
Score = 184 bits (447), Expect = 5e-45
Identities = 85/152 (55%), Positives = 113/152 (74%)
Frame = +2
Query: 509 PDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDE 688
P + ++ R++L +GE+PER GLLKTP R AK T GY + ++N+AIF DE
Sbjct: 44 PAIEDAVRVILKQIGENPEREGLLKTPSRVAKMYAELTAGYHIDPDALINDAIFSVSYDE 103
Query: 689 MVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQ 868
MV+VK+IE S+CEHH++PF G+V + Y+P GK++GLSK+ RIVE+F+RRLQVQER+T Q
Sbjct: 104 MVLVKNIEFASLCEHHMLPFMGRVHVAYIPNGKVVGLSKIPRIVEMFARRLQVQERMTVQ 163
Query: 869 IAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQK 964
IA + Q + P GVAVV EGVHMC VMRGV+K
Sbjct: 164 IADFINQRLEPLGVAVVAEGVHMCAVMRGVKK 195
>UniRef50_A5WE14 Cluster: GTP cyclohydrolase I; n=4;
Pseudomonadales|Rep: GTP cyclohydrolase I -
Psychrobacter sp. PRwf-1
Length = 201
Score = 181 bits (441), Expect = 3e-44
Identities = 81/146 (55%), Positives = 110/146 (75%)
Frame = +2
Query: 527 YRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKD 706
Y L+ GED R GLL TP RAAKA + T+GY QSL EV NNA+F D E+V+V +
Sbjct: 23 YAKLIASTGEDLNRPGLLDTPTRAAKAFGYLTQGYHQSLTEVTNNAVFPTDNSELVLVHN 82
Query: 707 IEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVT 886
IE +S+CEHHL+PF+G +GYLP GK+LGLSK+ARI+++++RRLQ+QE L++Q+A A+
Sbjct: 83 IEFYSLCEHHLLPFHGVAHVGYLPDGKVLGLSKVARIIDMYARRLQIQESLSQQVAEAIM 142
Query: 887 QAVRPAGVAVVIEGVHMCMVMRGVQK 964
+ + GVAVV++ HMCM+MRGV K
Sbjct: 143 EVTQCRGVAVVMDASHMCMMMRGVNK 168
>UniRef50_Q8G0L4 Cluster: GTP cyclohydrolase I; n=20; Bacteria|Rep:
GTP cyclohydrolase I - Brucella suis
Length = 213
Score = 166 bits (403), Expect = 1e-39
Identities = 81/150 (54%), Positives = 107/150 (71%), Gaps = 2/150 (1%)
Frame = +2
Query: 530 RLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDT--DEMVVVK 703
R LL GEDP+R GLL+TP+R AKA GY +S EEVL F+E D+MV+VK
Sbjct: 38 RTLLLWAGEDPDREGLLETPKRVAKAYQELFGGYSESPEEVLGTT-FEEVAGYDDMVLVK 96
Query: 704 DIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAV 883
DI FS CEHH+VP GK + YLP+G+++GLSK+AR+V+IF+RRLQ QE +T QIA ++
Sbjct: 97 DISFFSHCEHHMVPIIGKAHVAYLPEGRVVGLSKIARVVDIFARRLQTQESITAQIADSM 156
Query: 884 TQAVRPAGVAVVIEGVHMCMVMRGVQKINS 973
+ ++P GVAV+IE HMCM MR ++K S
Sbjct: 157 QRILKPRGVAVMIEAEHMCMAMRSIRKQGS 186
>UniRef50_Q2Q448 Cluster: GTP cyclohydrolase I; n=1; Toxoplasma
gondii|Rep: GTP cyclohydrolase I - Toxoplasma gondii
Length = 262
Score = 163 bits (397), Expect = 6e-39
Identities = 82/159 (51%), Positives = 111/159 (69%), Gaps = 11/159 (6%)
Frame = +2
Query: 530 RLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFD-EDTDE------ 688
R++L +GED RAGL +TP+R A AM FF++GY ++V+ NA+F E+ E
Sbjct: 71 RMILRAMGEDVTRAGLRETPKRVAAAMEFFSRGYRADPKDVIRNALFSVEEGHEDGQYLA 130
Query: 689 ----MVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQER 856
MV V I++ S+CEHHL+PF+GK IGY+P +LG+SK ARI+EI+SRRLQ+QER
Sbjct: 131 GKQGMVTVGRIDISSLCEHHLLPFFGKCHIGYIPDKHVLGISKFARIMEIYSRRLQIQER 190
Query: 857 LTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINS 973
LT+QIA+AV + +P GVAV++E HMCM MRGV S
Sbjct: 191 LTQQIALAVMKVAKPRGVAVLLECTHMCMAMRGVSSPGS 229
>UniRef50_Q3WEZ6 Cluster: GTP cyclohydrolase I; n=7; Bacteria|Rep:
GTP cyclohydrolase I - Frankia sp. EAN1pec
Length = 257
Score = 162 bits (393), Expect = 2e-38
Identities = 80/152 (52%), Positives = 108/152 (71%), Gaps = 2/152 (1%)
Frame = +2
Query: 515 MANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMV 694
+A + R LL G+GEDP+R GL KTP+R A+A +G + EVL +FDE DEMV
Sbjct: 76 VARAVRELLIGIGEDPDREGLRKTPDRVARAYQEAVEGLGRDPAEVLTT-VFDEGHDEMV 134
Query: 695 VVKDIEMFSMCEHHLVPFYGKVSIGYLP--QGKILGLSKLARIVEIFSRRLQVQERLTKQ 868
+V+DI+ S+CEHHLV F GK + Y+P +G+I GLSKLAR+V++++RR QVQERLT Q
Sbjct: 135 LVRDIDFSSLCEHHLVVFAGKAHVAYIPNEKGQITGLSKLARLVDLYARRPQVQERLTSQ 194
Query: 869 IAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQK 964
+A A+ + P GV VV+E H+CM MRGV+K
Sbjct: 195 VADALVDVLDPRGVMVVVEAEHLCMSMRGVRK 226
>UniRef50_Q8G3S1 Cluster: GTP cyclohydrolase I; n=4;
Bifidobacterium|Rep: GTP cyclohydrolase I -
Bifidobacterium longum
Length = 199
Score = 158 bits (383), Expect = 3e-37
Identities = 77/146 (52%), Positives = 105/146 (71%), Gaps = 1/146 (0%)
Frame = +2
Query: 530 RLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKDI 709
RL L +GEDPER GL++TP+R A+A G S + L FD DTDE+V+VKDI
Sbjct: 25 RLFLKSIGEDPEREGLVETPDRIARACRELFTGLQASPADALEKH-FDVDTDELVLVKDI 83
Query: 710 EMFSMCEHHLVPFYGKVSIGYLP-QGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVT 886
E++S+CEHHL+PF+G +GY+P + ++GLSKLAR+VE+++RR QVQERLT+QIA A+
Sbjct: 84 ELYSVCEHHLLPFHGVAHVGYIPAKDGVMGLSKLARLVEVYARRPQVQERLTQQIADALV 143
Query: 887 QAVRPAGVAVVIEGVHMCMVMRGVQK 964
+ GV VV E H+CM MRG++K
Sbjct: 144 EYAGARGVIVVTECEHLCMSMRGIKK 169
>UniRef50_Q92QB4 Cluster: GTP cyclohydrolase I; n=49;
Proteobacteria|Rep: GTP cyclohydrolase I - Rhizobium
meliloti (Sinorhizobium meliloti)
Length = 204
Score = 157 bits (381), Expect = 5e-37
Identities = 81/163 (49%), Positives = 107/163 (65%), Gaps = 2/163 (1%)
Frame = +2
Query: 482 RPPTREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNN 661
RP +EA + R+LL GEDP R GL TP R AKA GYD E+VL
Sbjct: 16 RPTQKEA-----EEAVRVLLRWAGEDPAREGLKDTPSRVAKAYREIFGGYDLVAEDVLGR 70
Query: 662 AIFDEDT--DEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSR 835
F+E + D++V+ KDI +S CEHH+VP GK I YLP G++LGLSK+AR+V+I++R
Sbjct: 71 T-FEEVSGYDDIVLEKDIPFYSHCEHHMVPIIGKAHIAYLPNGRVLGLSKIARVVDIYAR 129
Query: 836 RLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQK 964
RLQ QE +T QIA A+ + + P GVAV+IE H+CM MRG++K
Sbjct: 130 RLQTQEAMTAQIAKAIDETLMPRGVAVMIEAEHLCMAMRGIKK 172
>UniRef50_P0C0C1 Cluster: GTP cyclohydrolase I; n=23; Bacteria|Rep:
GTP cyclohydrolase I - Streptococcus pyogenes
Length = 194
Score = 154 bits (374), Expect = 4e-36
Identities = 76/146 (52%), Positives = 99/146 (67%), Gaps = 1/146 (0%)
Frame = +2
Query: 539 LTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKDIEMF 718
L +GE+P R GLL TP+R AK G + +E A+F E +++V+VKDI +
Sbjct: 22 LEAIGENPNREGLLDTPKRVAKMYAEMFAGLKKDPKEEFT-AVFTEHHEDVVIVKDISFY 80
Query: 719 SMCEHHLVPFYGKVSIGYLPQ-GKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQAV 895
SMCEHH VPFYGK I YLP G++ GLSKLAR VE+ S+R Q+QERLT QIA A+ +A+
Sbjct: 81 SMCEHHQVPFYGKAHIAYLPSDGRVTGLSKLARAVEVASKRPQLQERLTAQIADALVEAL 140
Query: 896 RPAGVAVVIEGVHMCMVMRGVQKINS 973
P GV V++E HMCM MRG++K S
Sbjct: 141 HPTGVLVLVEAEHMCMTMRGIKKPGS 166
>UniRef50_Q68WZ4 Cluster: GTP cyclohydrolase 1; n=25; Bacteria|Rep:
GTP cyclohydrolase 1 - Rickettsia typhi
Length = 190
Score = 153 bits (371), Expect = 9e-36
Identities = 74/163 (45%), Positives = 107/163 (65%), Gaps = 1/163 (0%)
Frame = +2
Query: 488 PTREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAI 667
PTRE + + R LL +GEDP R GLLKTP+R + + GY + ++E+LN
Sbjct: 4 PTRE----EAKEAVRTLLRFIGEDPTREGLLKTPDRVINSYMEIFSGYGKDVQEILNTKF 59
Query: 668 FDE-DTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQ 844
+D + +++ ++ I+ S CEHH++PF G V I Y+P I+G+SKLARIV IFSRRLQ
Sbjct: 60 YDTYNFQDLISLEGIKFTSFCEHHILPFNGTVHIAYIPDNCIIGVSKLARIVNIFSRRLQ 119
Query: 845 VQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINS 973
+QE++T QIA ++ ++++P GVA+ I H CM MRGV NS
Sbjct: 120 IQEKMTVQIAESIQESLKPLGVAIKISAFHSCMSMRGVMHDNS 162
>UniRef50_O69531 Cluster: GTP cyclohydrolase I; n=98; Bacteria|Rep:
GTP cyclohydrolase I - Mycobacterium leprae
Length = 205
Score = 153 bits (371), Expect = 9e-36
Identities = 75/147 (51%), Positives = 102/147 (69%), Gaps = 2/147 (1%)
Frame = +2
Query: 530 RLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKDI 709
R LL +GEDP+R GL TP R A+A G + VLN +FDE+ +E+V+VK+I
Sbjct: 29 RELLYAIGEDPDREGLADTPARVARACRELFSGLYTDPQTVLNT-MFDEEHNELVIVKEI 87
Query: 710 EMFSMCEHHLVPFYGKVSIGYLP--QGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAV 883
M+S CEHHLV F+G IGYLP G++ GLSK+AR+V+++++R QVQERLT QIA A+
Sbjct: 88 PMYSTCEHHLVSFHGVAHIGYLPGADGRVTGLSKIARLVDLYAKRPQVQERLTSQIADAL 147
Query: 884 TQAVRPAGVAVVIEGVHMCMVMRGVQK 964
+ P GV +V+E H+CM MRGV+K
Sbjct: 148 VSKLDPRGVIIVVEAEHLCMAMRGVRK 174
>UniRef50_A6SZ52 Cluster: GTP cyclohydrolase I; n=2; root|Rep: GTP
cyclohydrolase I - Janthinobacterium sp. (strain
Marseille) (Minibacterium massiliensis)
Length = 198
Score = 153 bits (370), Expect = 1e-35
Identities = 76/148 (51%), Positives = 103/148 (69%), Gaps = 3/148 (2%)
Frame = +2
Query: 527 YRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFD---EDTDEMVV 697
+R LLT LGE+ +R GL +TP+R KA +T GYDQ E+L +F+ E +E++V
Sbjct: 20 WRRLLTHLGENADRQGLRETPQRVEKAWKHWTSGYDQDPAEILK--VFEDGAEQYNELIV 77
Query: 698 VKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAI 877
V+ I ++S CEHHL PF+G +IGY P GKI+GLSKL R+V+ F++RLQVQERLT QIA
Sbjct: 78 VRGIPVYSHCEHHLAPFFGTATIGYTPNGKIVGLSKLTRLVDCFAKRLQVQERLTIQIAD 137
Query: 878 AVTQAVRPAGVAVVIEGVHMCMVMRGVQ 961
+ + V+P V VVI HMCM RG++
Sbjct: 138 TLMEHVQPLSVGVVIRCRHMCMESRGIR 165
>UniRef50_A5EFZ1 Cluster: GTP cyclohydrolase I; n=6;
Proteobacteria|Rep: GTP cyclohydrolase I -
Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)
Length = 206
Score = 151 bits (365), Expect = 5e-35
Identities = 70/153 (45%), Positives = 106/153 (69%), Gaps = 2/153 (1%)
Frame = +2
Query: 512 DMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDT--D 685
D+ ++ R +LT +GEDP R GL +TP R A+A + GYDQ+ EE L F+E D
Sbjct: 21 DVEDAIRTILTWIGEDPSREGLSETPARVARAYKSYFAGYDQNPEEYLRKT-FEETAGYD 79
Query: 686 EMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTK 865
EMV++++I S CEHH+ P G+ +GY+P+ +++G+SKLAR+VE ++ RLQ+QER+T
Sbjct: 80 EMVLLRNIPFQSHCEHHMAPIIGRAWVGYVPRSRVVGISKLARVVEAYASRLQIQERMTA 139
Query: 866 QIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQK 964
+IA + + ++P GVAVVI+ H C+ RGV+K
Sbjct: 140 EIANIIDEVLQPQGVAVVIKAAHHCISSRGVKK 172
>UniRef50_Q6NF93 Cluster: GTP cyclohydrolase I; n=8; Bacteria|Rep:
GTP cyclohydrolase I - Corynebacterium diphtheriae
Length = 190
Score = 150 bits (364), Expect = 6e-35
Identities = 76/147 (51%), Positives = 100/147 (68%), Gaps = 2/147 (1%)
Frame = +2
Query: 530 RLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKDI 709
R LL +GEDP+R GL +TP R AKA G EVL F ED E+V+V+DI
Sbjct: 15 RELLIAVGEDPDREGLQETPARVAKAYAEMFAGLHTDPTEVLAKT-FSEDHREVVLVRDI 73
Query: 710 EMFSMCEHHLVPFYGKVSIGYLP--QGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAV 883
++S CEHHLVPF+GK IGY+P GK+ GLSKLAR+V+++++R QVQERLT Q+A A+
Sbjct: 74 PIYSTCEHHLVPFFGKAHIGYIPGESGKVTGLSKLARLVDLYAKRPQVQERLTTQVADAL 133
Query: 884 TQAVRPAGVAVVIEGVHMCMVMRGVQK 964
++ V VVIE H+CM MRG++K
Sbjct: 134 VDKLQAQAVIVVIECEHLCMAMRGIRK 160
>UniRef50_A2U8J6 Cluster: GTP cyclohydrolase I; n=2; Bacillus|Rep:
GTP cyclohydrolase I - Bacillus coagulans 36D1
Length = 215
Score = 150 bits (364), Expect = 6e-35
Identities = 74/146 (50%), Positives = 97/146 (66%), Gaps = 1/146 (0%)
Frame = +2
Query: 530 RLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAI-FDEDTDEMVVVKD 706
R L+ G+DP+R GL +TP R KA L +T+GY + + L D D E+V+VKD
Sbjct: 41 RSLIDLCGDDPDRDGLQETPYRVLKAFLEYTEGYREDPKLHLAKTFDVDHDHKELVLVKD 100
Query: 707 IEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVT 886
IE +S+CEHH PF+G + Y P KI GLSK+AR+V+ ++RR QVQERLTKQIA AV
Sbjct: 101 IEFYSICEHHFAPFFGVAHVAYFPNEKITGLSKIARMVDGYARRFQVQERLTKQIADAVE 160
Query: 887 QAVRPAGVAVVIEGVHMCMVMRGVQK 964
+ + P G VV+E HMCM RGV+K
Sbjct: 161 EVLEPQGTMVVLEAKHMCMCGRGVKK 186
>UniRef50_Q89IW2 Cluster: GTP cyclohydrolase I; n=13; Bacteria|Rep:
GTP cyclohydrolase I - Bradyrhizobium japonicum
Length = 229
Score = 149 bits (362), Expect = 1e-34
Identities = 75/147 (51%), Positives = 98/147 (66%), Gaps = 2/147 (1%)
Frame = +2
Query: 530 RLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDT--DEMVVVK 703
+ LL +GE+ ER GLL TP R +A +GY Q EVL+ F E D+ V+V+
Sbjct: 52 KTLLAYIGENTEREGLLDTPRRVVEAFDELYQGYHQCPAEVLDRT-FGETAGYDDFVLVR 110
Query: 704 DIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAV 883
DIE S CEHH++PFYGK I Y P +++GLSKLAR+ +IF+RRLQ QE LT QIA A+
Sbjct: 111 DIEFTSQCEHHMMPFYGKAHIAYTPVERVVGLSKLARLTDIFARRLQTQEHLTAQIAAAI 170
Query: 884 TQAVRPAGVAVVIEGVHMCMVMRGVQK 964
+ ++P GVAV+IE H CM +RGV K
Sbjct: 171 DEVLKPRGVAVLIEAEHTCMSVRGVAK 197
>UniRef50_Q5NN57 Cluster: GTP cyclohydrolase I; n=4;
Sphingomonadales|Rep: GTP cyclohydrolase I - Zymomonas
mobilis
Length = 220
Score = 149 bits (361), Expect = 1e-34
Identities = 74/178 (41%), Positives = 110/178 (61%), Gaps = 2/178 (1%)
Frame = +2
Query: 443 ENCTFHHDLELDHRPPTREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFT 622
+N T +L P + + ++ + R L+ G+DP+R GL+ TP+R AKA ++
Sbjct: 16 QNITMEEIQDLAVMRPDQVNVPEEIQEAIRSLIRWAGDDPDREGLIDTPKRVAKAWKYYC 75
Query: 623 KGYDQSLEEVLNNAIFDE--DTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILG 796
+GY + E L +F+E D++V++KDI +S CEHH+ P G I YLP K++G
Sbjct: 76 RGYREDPENHLKT-VFEEVGGYDDIVLLKDIPFYSHCEHHMAPIMGHAHIAYLPDKKVVG 134
Query: 797 LSKLARIVEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKIN 970
LSKLAR+++ ++ RLQ+QERLT Q+A + +RP GVAVVI VH CM RGV+ N
Sbjct: 135 LSKLARVLKGYAHRLQIQERLTAQVADCIWNNLRPRGVAVVISAVHSCMAARGVETPN 192
>UniRef50_Q9PC02 Cluster: GTP cyclohydrolase I; n=16; Bacteria|Rep:
GTP cyclohydrolase I - Xylella fastidiosa
Length = 203
Score = 149 bits (360), Expect = 2e-34
Identities = 74/167 (44%), Positives = 103/167 (61%), Gaps = 3/167 (1%)
Frame = +2
Query: 473 LDHRPPTREALLPDMAN-SYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEE 649
+DH ++ A + R LL GEDP R GLL TP R +A + GY + +
Sbjct: 1 MDHSKQQNASITQAQAEEAVRTLLRWAGEDPTREGLLDTPRRVVEAYGDWFSGYREDPHD 60
Query: 650 VLNNAIFDEDT--DEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVE 823
L F+E + DE++V+++I S CEHH+ P GKV IGYLP GK++G+SKLAR+VE
Sbjct: 61 YLQRT-FEEISGYDELIVLRNITYESHCEHHMAPIIGKVHIGYLPNGKVVGISKLARVVE 119
Query: 824 IFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQK 964
++RR Q+QE++T QIA + + + P GV VVIEG H CM RG+ K
Sbjct: 120 SYARRFQIQEKMTAQIAACIQETLTPRGVGVVIEGAHACMTTRGIHK 166
>UniRef50_A4G565 Cluster: GTP cyclohydrolase I; n=2;
Betaproteobacteria|Rep: GTP cyclohydrolase I -
Herminiimonas arsenicoxydans
Length = 215
Score = 148 bits (359), Expect = 2e-34
Identities = 74/150 (49%), Positives = 101/150 (67%), Gaps = 3/150 (2%)
Frame = +2
Query: 521 NSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTD---EM 691
+ +R LL LGE+P R GL +TP+R KA +T GY Q E+L +F + + E+
Sbjct: 35 HDWRRLLIHLGENPNRQGLQETPKRVQKAWQQWTAGYAQDPAEILK--VFSDGAEQYKEL 92
Query: 692 VVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQI 871
++V+ I ++S CEHHL PF+G +IGY P GKI+GLSKL R+V+ ++RRLQVQERLT QI
Sbjct: 93 IIVRGIPVYSHCEHHLAPFFGTATIGYTPNGKIVGLSKLTRLVDCYARRLQVQERLTIQI 152
Query: 872 AIAVTQAVRPAGVAVVIEGVHMCMVMRGVQ 961
A + + V+P V VVI HMCM RG+Q
Sbjct: 153 AETLMEHVQPLSVGVVIRCRHMCMESRGIQ 182
>UniRef50_Q0CVT9 Cluster: GTP cyclohydrolase I; n=1; Aspergillus
terreus NIH2624|Rep: GTP cyclohydrolase I - Aspergillus
terreus (strain NIH 2624)
Length = 216
Score = 147 bits (356), Expect = 6e-34
Identities = 77/153 (50%), Positives = 102/153 (66%)
Frame = +2
Query: 515 MANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMV 694
+A + R +L +GEDP R GL TPER AKAML+FTKGY +++ + N AIF ED ++
Sbjct: 56 IAKAVRTILECVGEDPGREGLRATPERYAKAMLYFTKGYSENIFDRANGAIFHEDYKGLI 115
Query: 695 VVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIA 874
V+ IGY+P G+ILGLSK+A + E+FSRRLQVQERLT+Q+A
Sbjct: 116 VMH--------------------IGYIPDGRILGLSKMAHLAEVFSRRLQVQERLTEQVA 155
Query: 875 IAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINS 973
IAV ++P GV VV+E H+CM+MRGVQK+ S
Sbjct: 156 IAVFNVLKPQGVGVVMESSHLCMIMRGVQKVRS 188
>UniRef50_A2BL58 Cluster: GTP cyclohydrolase I; n=2;
Thermoprotei|Rep: GTP cyclohydrolase I - Hyperthermus
butylicus (strain DSM 5456 / JCM 9403)
Length = 193
Score = 147 bits (356), Expect = 6e-34
Identities = 72/144 (50%), Positives = 97/144 (67%)
Frame = +2
Query: 530 RLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKDI 709
R++L +GEDPER GL +TP R A +GYD + E F E TD +VVV I
Sbjct: 13 RMILEAIGEDPEREGLRETPRRVADMFEELLEGYDFTEEYTW----FTEATD-LVVVSGI 67
Query: 710 EMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQ 889
+S+CEHHL+PF+G + YLP+GK++GLSK+ RIV +SRRLQ+QER+TKQIA +++
Sbjct: 68 RFYSLCEHHLLPFFGVAHVAYLPRGKVIGLSKIVRIVNKYSRRLQIQERMTKQIADEISK 127
Query: 890 AVRPAGVAVVIEGVHMCMVMRGVQ 961
A V V+ E VH+CM MRGV+
Sbjct: 128 ATGSPDVMVITEAVHLCMAMRGVR 151
>UniRef50_Q7VFG4 Cluster: GTP cyclohydrolase I; n=6;
Helicobacter|Rep: GTP cyclohydrolase I - Helicobacter
hepaticus
Length = 206
Score = 144 bits (349), Expect = 4e-33
Identities = 64/142 (45%), Positives = 95/142 (66%)
Frame = +2
Query: 527 YRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKD 706
+ L +GE+P R GLL TP+R A A GY +S ++ L + D DEM+V+K
Sbjct: 32 FESLCQNVGENPTREGLLHTPKRIASAFSDMLNGYAKSPKQALGSVFEDGVCDEMIVLKK 91
Query: 707 IEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVT 886
+ +S+CEHHL+PF+G +SIGY+P K++G+S LAR+ E+F+ RLQ+QERLT QIA A+
Sbjct: 92 LHFYSICEHHLLPFFGHISIGYIPDKKLVGISGLARLTEVFTHRLQIQERLTAQIADALI 151
Query: 887 QAVRPAGVAVVIEGVHMCMVMR 952
++P G +V + H+C+ MR
Sbjct: 152 AELKPKGAMIVCQARHLCLEMR 173
>UniRef50_UPI0000DADB56 Cluster: hypothetical protein
RcanM_01000666; n=1; Rickettsia canadensis str.
McKiel|Rep: hypothetical protein RcanM_01000666 -
Rickettsia canadensis str. McKiel
Length = 222
Score = 144 bits (348), Expect = 5e-33
Identities = 71/163 (43%), Positives = 104/163 (63%), Gaps = 1/163 (0%)
Frame = +2
Query: 488 PTREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAI 667
P+RE + + R LL +GEDP R GLLKTP+R + + GY++ + E+L+
Sbjct: 36 PSRE----EAKEAVRTLLKFIGEDPNREGLLKTPDRVINSYMEIFSGYEKDVAEILSTKF 91
Query: 668 FDE-DTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQ 844
+D + + + + I S CEHH++PF G V I Y+P I+G+SKLARIV +F+RRLQ
Sbjct: 92 YDTCNFQDFISLDGIRFTSFCEHHMLPFNGTVHISYIPDNCIIGISKLARIVNVFARRLQ 151
Query: 845 VQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINS 973
+QE++T QIA +V ++P GVAV I +H CM +RGV + NS
Sbjct: 152 IQEKMTVQIAESVQDNLKPLGVAVRISALHSCMSIRGVIQDNS 194
>UniRef50_Q1IAJ6 Cluster: Putative GTP cyclohydrolase I; n=1;
Pseudomonas entomophila L48|Rep: Putative GTP
cyclohydrolase I - Pseudomonas entomophila (strain L48)
Length = 202
Score = 143 bits (346), Expect = 9e-33
Identities = 68/148 (45%), Positives = 98/148 (66%), Gaps = 2/148 (1%)
Frame = +2
Query: 536 LLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTD--EMVVVKDI 709
+L LGED R GL +TPER K+M+ T GY Q VL F+E ++++++I
Sbjct: 19 ILEYLGEDTNRQGLHETPERFLKSMVAQTVGYSQDPYRVLEK-FFEEVAGYKNLIMLQNI 77
Query: 710 EMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQ 889
SMCEHHL P G ++GY+P G+++GLSKLAR+V+IF++RLQ+QERLT +I +A+ +
Sbjct: 78 HFESMCEHHLAPIVGNATVGYIPNGRVVGLSKLARVVDIFAKRLQIQERLTSEIGLALDE 137
Query: 890 AVRPAGVAVVIEGVHMCMVMRGVQKINS 973
+RP GV V+I H C+ RG K N+
Sbjct: 138 VLRPKGVGVIIRAKHNCLCTRGAYKPNA 165
>UniRef50_A4QTK3 Cluster: Putative uncharacterized protein; n=1;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 216
Score = 140 bits (340), Expect = 5e-32
Identities = 72/150 (48%), Positives = 101/150 (67%)
Frame = +2
Query: 515 MANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMV 694
+A + R ++ +GEDP R GL +TP R A+A+ FFT+GY +++ EV N+AIF D+ E+V
Sbjct: 53 IAAAAREIICAVGEDPAREGLAETPNRYAEALQFFTQGYSKNIHEVSNDAIFSIDSRELV 112
Query: 695 VVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIA 874
++ IGY+P G++LGLSKL RI E+++RRLQ+QERLTKQ+
Sbjct: 113 IMH--------------------IGYVPNGRVLGLSKLPRIAEVYARRLQIQERLTKQVG 152
Query: 875 IAVTQAVRPAGVAVVIEGVHMCMVMRGVQK 964
A+ + + P GVAVV+E HMCMVMRGVQK
Sbjct: 153 EAINEVLSPLGVAVVLECTHMCMVMRGVQK 182
>UniRef50_A7QSC6 Cluster: Chromosome chr3 scaffold_158, whole genome
shotgun sequence; n=2; Vitis vinifera|Rep: Chromosome
chr3 scaffold_158, whole genome shotgun sequence - Vitis
vinifera (Grape)
Length = 214
Score = 138 bits (333), Expect = 3e-31
Identities = 72/177 (40%), Positives = 112/177 (63%), Gaps = 5/177 (2%)
Frame = +2
Query: 458 HHDLELDHRPPTREALLPD---MANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKG 628
H +EL+ P+ + + ++LL GLGED R G+ KTP R AKA+ T+G
Sbjct: 8 HFSVELEDGVNVEVGFEPETLPIEEAVKVLLQGLGEDINREGIRKTPARVAKALCEGTRG 67
Query: 629 YDQSLEEVLNNAIFDEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQG-KILGLSK 805
Y Q ++++ A+F E +V+V+D+++FS CE L+PF K +GY+P G +++GLSK
Sbjct: 68 YRQKAKDIVQGALFPEAVGGLVIVRDLDLFSYCESCLLPFQVKCHVGYVPSGQQVVGLSK 127
Query: 806 LAR-IVEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINS 973
L+R IV + +LQVQERLT+Q++ V+ ++ V VV+E H CMV RG++K+ S
Sbjct: 128 LSRSIVHFYGFKLQVQERLTRQVSETVS-SLLGGDVIVVVEASHSCMVSRGIEKLGS 183
>UniRef50_A0RYT5 Cluster: GTP cyclohydrolase I; n=2;
Thermoprotei|Rep: GTP cyclohydrolase I - Cenarchaeum
symbiosum
Length = 189
Score = 137 bits (332), Expect = 5e-31
Identities = 73/145 (50%), Positives = 97/145 (66%), Gaps = 1/145 (0%)
Frame = +2
Query: 530 RLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKDI 709
R L+ LGEDP R GL +TP R A+ GY+ E + F ED+D VV +DI
Sbjct: 11 RELIIELGEDPTREGLRETPARMARMYGEIFGGYESDAELSVQ---FSEDSDA-VVARDI 66
Query: 710 EMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAV-T 886
+S+CEHH++PF+G + I YLP GK+ G+SKL R+VE +SRRLQ+QERLT+ IA + +
Sbjct: 67 GFYSVCEHHMLPFFGSIHIAYLPDGKVFGVSKLVRLVEKYSRRLQIQERLTRNIADELSS 126
Query: 887 QAVRPAGVAVVIEGVHMCMVMRGVQ 961
Q V+ GVAVV E H+CM MRGV+
Sbjct: 127 QGVK--GVAVVAEAEHLCMKMRGVR 149
>UniRef50_Q82Z12 Cluster: GTP cyclohydrolase I; n=1; Enterococcus
faecalis|Rep: GTP cyclohydrolase I - Enterococcus
faecalis (Streptococcus faecalis)
Length = 186
Score = 135 bits (327), Expect = 2e-30
Identities = 72/144 (50%), Positives = 95/144 (65%), Gaps = 2/144 (1%)
Frame = +2
Query: 536 LLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDE-DTDEMVVVKDIE 712
+L +GED +RAGL+ TP+R AK G + E + +FD + EMV+VKDI
Sbjct: 16 ILEAVGEDTQRAGLIDTPKRVAKMYAEVFSGLTEP--EFDDYKLFDSLNEGEMVLVKDIA 73
Query: 713 MFSMCEHHLVPFYGKVSIGYLPQG-KILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQ 889
+SMCEHHL+PFYGKV + YLP+G K+LGLSKL R+VE ++R VQE LT IA + +
Sbjct: 74 FYSMCEHHLLPFYGKVHVAYLPEGGKVLGLSKLPRLVEHCAKRPTVQEDLTVTIARKLQE 133
Query: 890 AVRPAGVAVVIEGVHMCMVMRGVQ 961
+ G+AV IE HMCM MRGV+
Sbjct: 134 NIPVKGIAVAIEAEHMCMTMRGVK 157
>UniRef50_Q88ST4 Cluster: GTP cyclohydrolase I; n=11;
Lactobacillales|Rep: GTP cyclohydrolase I -
Lactobacillus plantarum
Length = 189
Score = 130 bits (313), Expect = 9e-29
Identities = 69/152 (45%), Positives = 101/152 (66%), Gaps = 4/152 (2%)
Frame = +2
Query: 521 NSYRLLLTGLGEDPERAGLLKTPERAAK--AMLFFTKGYDQSLEEVLNNAIFD-EDTDEM 691
++ R +L+ +GEDP+R GL++TP R A+ A +F TK + N +F E EM
Sbjct: 12 HAVREILSAVGEDPDRPGLVETPARVARMYAEVFATK----TAAPFDNYKLFKVEHPTEM 67
Query: 692 VVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGK-ILGLSKLARIVEIFSRRLQVQERLTKQ 868
V++KDI +SMCEHHL+PF+G V + Y+PQ + ++GLSK+ R+++ S++ VQERLT
Sbjct: 68 VLLKDIPFYSMCEHHLLPFFGTVQVAYVPQHEQVIGLSKIPRLIDYCSQQPNVQERLTVS 127
Query: 869 IAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQK 964
IA + + + PAG+AV I HMCM MRGV K
Sbjct: 128 IATELQRILDPAGIAVSITARHMCMEMRGVSK 159
>UniRef50_Q97D54 Cluster: GTP cyclohydrolase I; n=7;
Clostridium|Rep: GTP cyclohydrolase I - Clostridium
acetobutylicum
Length = 195
Score = 129 bits (311), Expect = 2e-28
Identities = 67/153 (43%), Positives = 98/153 (64%), Gaps = 8/153 (5%)
Frame = +2
Query: 530 RLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLN--NAIFDEDT-----DE 688
R +L LG+DP+R GL +TP+R AK KG + S +++ N F+ED D
Sbjct: 13 RGILIALGDDPDREGLKETPKRVAKMYEEVFKGMEYSNDDIAEMFNKTFEEDLKESEEDN 72
Query: 689 MVVVKDIEMFSMCEHHLVPFYGK-VSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTK 865
+V+VKDIE+FS CEHHL Y V++ Y+P +++GLSK+ARI ++ SRRLQ+QER+ K
Sbjct: 73 IVLVKDIEIFSHCEHHLTLMYNMTVAVAYIPNKRLIGLSKIARIADMVSRRLQLQERIGK 132
Query: 866 QIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQK 964
IA + + +AV+I+G H CM RG++K
Sbjct: 133 DIAEIMEKVTASKDIAVIIKGEHGCMTSRGIKK 165
>UniRef50_A5Z385 Cluster: Putative uncharacterized protein; n=1;
Eubacterium ventriosum ATCC 27560|Rep: Putative
uncharacterized protein - Eubacterium ventriosum ATCC
27560
Length = 151
Score = 123 bits (297), Expect = 8e-27
Identities = 57/116 (49%), Positives = 83/116 (71%)
Frame = +2
Query: 626 GYDQSLEEVLNNAIFDEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSK 805
G ++S +E L+ F D + +V+ KDI +S CEHHL+PFYGKV I Y+P GK++G+SK
Sbjct: 8 GMNRSPKEHLSKT-FTCDNENVVIEKDITFYSTCEHHLMPFYGKVHIAYIPNGKVVGISK 66
Query: 806 LARIVEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINS 973
LAR VE+++RRLQ+QE++T QIA A+ + + GV V+ + HMCM RG++K S
Sbjct: 67 LARTVEVYARRLQIQEQMTNQIAKALEKYLGAKGVLVMAQAEHMCMSARGIKKPGS 122
>UniRef50_A1SM21 Cluster: GTP cyclohydrolase I precursor; n=7;
Actinomycetales|Rep: GTP cyclohydrolase I precursor -
Nocardioides sp. (strain BAA-499 / JS614)
Length = 219
Score = 121 bits (291), Expect = 4e-26
Identities = 65/142 (45%), Positives = 87/142 (61%)
Frame = +2
Query: 536 LLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKDIEM 715
LL LG D E +++TP R A G D L N E DE+V+V +I +
Sbjct: 47 LLRALGLDIETDEMVETPRRLVAAYHELLTGPDVDLTTFPNT----EGYDELVLVANIPV 102
Query: 716 FSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQAV 895
S+CEHH++PF G +GYLP +ILGLSK AR+VE+ +RR Q QERLT ++A +T +
Sbjct: 103 RSVCEHHMLPFVGVAHVGYLPDERILGLSKFARLVELVARRPQTQERLTTEVADHLTTHL 162
Query: 896 RPAGVAVVIEGVHMCMVMRGVQ 961
+P GV VVIE H CM +RGV+
Sbjct: 163 QPRGVGVVIEAEHTCMSLRGVR 184
>UniRef50_Q8S3C2 Cluster: GTP cyclohydrolase I; n=7; core
eudicotyledons|Rep: GTP cyclohydrolase I - Arabidopsis
thaliana (Mouse-ear cress)
Length = 466
Score = 120 bits (290), Expect = 6e-26
Identities = 69/170 (40%), Positives = 106/170 (62%), Gaps = 12/170 (7%)
Frame = +2
Query: 464 DLELDHRPPTREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSL 643
+L +H+P T + ++ +LLL GL ED R G+ KTP R AKA+ T+GY Q +
Sbjct: 23 ELAFEHQPETLA-----IQDAVKLLLQGLHEDVNREGIKKTPFRVAKALREGTRGYKQKV 77
Query: 644 EEVLNNAIFDE-DTDE----------MVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQG-K 787
++ + +A+F E DE +VVV+D++ +S CE L+PF+ K IGY+P G +
Sbjct: 78 KDYVQSALFPEAGLDEGVGQAGGVGGLVVVRDLDHYSYCESCLLPFHVKCHIGYVPSGQR 137
Query: 788 ILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHM 937
+LGLSK +R+ ++F++RLQ +RL I A+ V+PAGVAVV+E H+
Sbjct: 138 VLGLSKFSRVTDVFAKRLQDPQRLADDICSALQHWVKPAGVAVVLECSHI 187
Score = 99 bits (238), Expect = 1e-19
Identities = 63/161 (39%), Positives = 89/161 (55%), Gaps = 6/161 (3%)
Frame = +2
Query: 509 PDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDE 688
P+M ++ +L LGEDP R L+ TP R K ML F + + N A + + E
Sbjct: 268 PEMVSAVVSILKSLGEDPLRKELIATPTRFLKWMLNFQRTNLEMKLNSFNPAKVNGEVKE 327
Query: 689 MVVVKDIEM--FSMCEHHLVPFYGKVSIGYL-PQG---KILGLSKLARIVEIFSRRLQVQ 850
+ ++ M +SMCEHHL+PFYG V IGY +G +G S + IV + +LQVQ
Sbjct: 328 KRLHCELNMPFWSMCEHHLLPFYGVVHIGYFCAEGSNPNPVGSSLMKAIVHFYGFKLQVQ 387
Query: 851 ERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINS 973
ER+T+QIA ++ V V VV E H CM+ RG++K S
Sbjct: 388 ERMTRQIAETLSPLV-GGDVIVVAEAGHTCMISRGIEKFGS 427
>UniRef50_Q2GK14 Cluster: GTP cyclohydrolase I; n=2; Anaplasma
phagocytophilum HZ|Rep: GTP cyclohydrolase I - Anaplasma
phagocytophilum (strain HZ)
Length = 202
Score = 120 bits (288), Expect = 1e-25
Identities = 60/146 (41%), Positives = 86/146 (58%)
Frame = +2
Query: 506 LPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTD 685
+ + + R+++ +G+DP R GLLKTP R GY L + +D +
Sbjct: 14 IEEAEEAVRVIIRWMGDDPNREGLLKTPRRVLDYYKKSCSGYAPELLSHYSILPYDGSSS 73
Query: 686 EMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTK 865
EMV+VK+I S CEHHL P G I Y+P+ KILG+ +A IV FS+RLQ+QERLT
Sbjct: 74 EMVLVKNIGFSSNCEHHLSPICGVAHIAYMPKEKILGIGSIAHIVGCFSKRLQLQERLTN 133
Query: 866 QIAIAVTQAVRPAGVAVVIEGVHMCM 943
Q+A + + + P GVAV++E H C+
Sbjct: 134 QVAEYLEKILDPHGVAVLLEAEHWCV 159
>UniRef50_Q971G9 Cluster: GTP cyclohydrolase I; n=4;
Sulfolobaceae|Rep: GTP cyclohydrolase I - Sulfolobus
tokodaii
Length = 215
Score = 120 bits (288), Expect = 1e-25
Identities = 63/163 (38%), Positives = 101/163 (61%), Gaps = 7/163 (4%)
Frame = +2
Query: 494 REALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEV----LNN 661
+E ++ ++A R +L LGE+P+R GL +TP R A+A+L T G ++ L+
Sbjct: 15 QEKMVEEIAKRIREILEILGENPDREGLRETPLRVARALLEMTSGLRTPQPQIKTFNLSE 74
Query: 662 AIFDEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYL--PQGKILGLSKLARIVEIFSR 835
E D++++VK+I S+CEHHL+P GKV + Y+ + K+ G SK+ RIV ++
Sbjct: 75 DGISEVEDQIILVKNIGFSSLCEHHLLPIIGKVHVAYIVGQERKVAGFSKIIRIVNYYAS 134
Query: 836 RLQVQERLTKQIAIAVTQA-VRPAGVAVVIEGVHMCMVMRGVQ 961
R Q+QERL +QIA A+ + + P GV V+ + +HMC +RGV+
Sbjct: 135 RPQIQERLVQQIADAIMNSDIHPKGVMVIGDALHMCAYVRGVK 177
>UniRef50_Q8RH43 Cluster: GTP cyclohydrolase I; n=3; Fusobacterium
nucleatum|Rep: GTP cyclohydrolase I - Fusobacterium
nucleatum subsp. nucleatum
Length = 187
Score = 118 bits (285), Expect = 2e-25
Identities = 57/151 (37%), Positives = 95/151 (62%)
Frame = +2
Query: 521 NSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVV 700
N++ ++ LG+ + L TP+R A + G D +EVL F+ +++E+++
Sbjct: 12 NAFFEVIEALGDVEYKEELKDTPKRIADSYKEIFYGIDIDPKEVLTKT-FEVNSNELIME 70
Query: 701 KDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIA 880
K+++ +SMCEHH +PF+G V I Y+P KI G + +++EI SRR Q+QERLT++IA
Sbjct: 71 KNMDFYSMCEHHFLPFFGTVCIAYVPNKKIFGFGDILKLIEILSRRPQLQERLTEEIAKY 130
Query: 881 VTQAVRPAGVAVVIEGVHMCMVMRGVQKINS 973
+ + + GV VV+E H+C+ MRG +K N+
Sbjct: 131 IYEILNCQGVYVVVEAKHLCVTMRGQKKENT 161
>UniRef50_Q01A10 Cluster: GTP cyclohydrolase I; n=2;
Ostreococcus|Rep: GTP cyclohydrolase I - Ostreococcus
tauri
Length = 504
Score = 118 bits (284), Expect = 3e-25
Identities = 63/160 (39%), Positives = 93/160 (58%), Gaps = 18/160 (11%)
Frame = +2
Query: 512 DMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDED---- 679
D++ R +L +GED ER GL+ TP R AKA+ F +GYD L A+F+ED
Sbjct: 56 DVSRCVREMLRAMGEDVEREGLMDTPARVAKALAFAMRGYDACPTAALGTALFNEDGLAR 115
Query: 680 -------------TDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQ-GKILGLSKLARI 817
T+++V+V+DI +FS C +PFYG + +GY P+ G I+GLSKLAR+
Sbjct: 116 ASSASTKEDVELGTNDVVLVRDIPVFSTCARTFMPFYGVIHVGYAPRAGVIVGLSKLARV 175
Query: 818 VEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHM 937
E++SRRLQ + L + +A A+ P GV V+ G+ +
Sbjct: 176 AEVYSRRLQTPDGLARAVAQALDDVASPLGVGVMFTGMQL 215
Score = 89.8 bits (213), Expect = 1e-16
Identities = 47/103 (45%), Positives = 61/103 (59%), Gaps = 2/103 (1%)
Frame = +2
Query: 671 DEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYL--PQGKILGLSKLARIVEIFSRRLQ 844
DE D + V +D+ M ++CEHHL+PF+G VS Y+ P + L L IV SRRLQ
Sbjct: 371 DEIEDGVCVTRDLHMSTVCEHHLLPFHGTVSAAYMTGPGAQPLSRDTLQAIVSRHSRRLQ 430
Query: 845 VQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINS 973
VQERLT+ IA ++ GV V H+CMV RGV+K S
Sbjct: 431 VQERLTRDIAEEISTLTGGVGVIVAARASHLCMVSRGVEKPGS 473
>UniRef50_Q2JC68 Cluster: GTP cyclohydrolase I; n=1; Frankia sp.
CcI3|Rep: GTP cyclohydrolase I - Frankia sp. (strain
CcI3)
Length = 192
Score = 117 bits (281), Expect = 7e-25
Identities = 66/144 (45%), Positives = 87/144 (60%)
Frame = +2
Query: 530 RLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKDI 709
R LL +GEDP R GL +TP R A+ F G+D E A + ++V V DI
Sbjct: 28 RQLLVEIGEDPGRDGLRETPARYARWWREFV-GFDPGNTET---AFEQVNHGQLVQVNDI 83
Query: 710 EMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQ 889
++S+CEHHL+PF+ +SI YL + K+LGLSK ARI + RLQVQERLT IA A+
Sbjct: 84 RVWSLCEHHLLPFWCDISIAYLAKDKLLGLSKFARIAHHHAHRLQVQERLTGAIADAIEA 143
Query: 890 AVRPAGVAVVIEGVHMCMVMRGVQ 961
VAV +G H+CM MRG++
Sbjct: 144 LCGVPDVAVRAKGEHLCMTMRGIR 167
>UniRef50_Q1Q0A8 Cluster: Strongly similar to GTP cyclohydrolase I;
n=1; Candidatus Kuenenia stuttgartiensis|Rep: Strongly
similar to GTP cyclohydrolase I - Candidatus Kuenenia
stuttgartiensis
Length = 212
Score = 117 bits (281), Expect = 7e-25
Identities = 62/150 (41%), Positives = 90/150 (60%), Gaps = 4/150 (2%)
Frame = +2
Query: 536 LLTGLGEDPERAGLLKTPERAAKAMLFFTKGYD--QSLEEVLNNAIFDEDTDEM--VVVK 703
+ T LG + A +TP R A++ T+GYD L +V + ++
Sbjct: 35 IFTTLGLNLNTAATKETPHRFINALIESTEGYDGDPKLVKVFETECRGGPDCRLSQIIEG 94
Query: 704 DIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAV 883
I F++CEHH +PFYG V +GY+ I+GLSKL R+V +FSRR +VQER+ +QIA +
Sbjct: 95 PIRFFALCEHHCLPFYGVVYVGYISHEHIIGLSKLTRLVHLFSRRFEVQERIGQQIADTL 154
Query: 884 TQAVRPAGVAVVIEGVHMCMVMRGVQKINS 973
Q + P GVAV IE H+C+ MRGV++I+S
Sbjct: 155 NQLLLPHGVAVYIEAHHLCVEMRGVKEISS 184
>UniRef50_Q8T649 Cluster: GTP cyclohydrolase I; n=3; Plasmodium
yoelii|Rep: GTP cyclohydrolase I - Plasmodium yoelii
yoelii
Length = 315
Score = 116 bits (278), Expect = 2e-24
Identities = 54/132 (40%), Positives = 87/132 (65%), Gaps = 2/132 (1%)
Frame = +2
Query: 575 LLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDED--TDEMVVVKDIEMFSMCEHHLVPF 748
L +T R AKA L+ T+GY S++ V+ +I+ + ++ +KDI ++S+C+HHL+PF
Sbjct: 142 LKRTNNRFAKAFLYLTEGYKMSVKNVIKKSIYKRKYKNNTLIKIKDIHVYSLCKHHLLPF 201
Query: 749 YGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEG 928
G I Y P I+GLSK +RI +I++RRLQ+QE LT I A+ + ++P + V I+
Sbjct: 202 EGLCDIEYNPDKYIMGLSKFSRITDIYARRLQLQEDLTNDICNALKKYLKPLYIKVTIKA 261
Query: 929 VHMCMVMRGVQK 964
H+C+ MRGV++
Sbjct: 262 KHLCINMRGVKE 273
>UniRef50_Q5HBC9 Cluster: GTP cyclohydrolase I; n=4; canis
group|Rep: GTP cyclohydrolase I - Ehrlichia ruminantium
(strain Welgevonden)
Length = 190
Score = 114 bits (274), Expect = 5e-24
Identities = 58/146 (39%), Positives = 87/146 (59%), Gaps = 1/146 (0%)
Frame = +2
Query: 512 DMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIF-DEDTDE 688
++ ++ LL+ +G+D +R GL+ TP R A F GY Q + V+ ++ +E D
Sbjct: 11 EVEDAISLLIRWIGDDVDRPGLIGTPRRMLNAYKKFFIGY-QDISLVIGGSVLPNEGYDS 69
Query: 689 MVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQ 868
M+ KDI S CEHH++P GKV+IGY+P I + ++ R+V FS+RLQVQERLT
Sbjct: 70 MITFKDIGFVSYCEHHIIPMRGKVNIGYVPDKVIFTIGQVIRLVNYFSKRLQVQERLTVD 129
Query: 869 IAIAVTQAVRPAGVAVVIEGVHMCMV 946
IA ++ + GV VVI H C++
Sbjct: 130 IAESINSYLVSKGVIVVINATHECVL 155
>UniRef50_Q6SIF0 Cluster: GTP cyclohydrolase I; n=1; Plasmodium
knowlesi|Rep: GTP cyclohydrolase I - Plasmodium knowlesi
Length = 451
Score = 114 bits (274), Expect = 5e-24
Identities = 58/177 (32%), Positives = 107/177 (60%), Gaps = 3/177 (1%)
Frame = +2
Query: 443 ENCTFHHDLELDHRPPTR-EALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFF 619
E C E + + T+ + + D++ S + +L + P + L KT R + L+
Sbjct: 231 EPCGIDTPRESNEKAGTKKDEQIADISRSIKKILRS-SKVPPKDILKKTGRRFSDTFLYL 289
Query: 620 TKGYDQSLEEVLNNAIFDED--TDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKIL 793
TKGY S+E+V+ +++ + + ++ + I ++S+C+HHL+PF G+ +I Y+P I+
Sbjct: 290 TKGYHMSVEKVIKKSLYKRNYKNNSVIKISGIHIYSLCKHHLLPFEGECTIEYIPNKYIM 349
Query: 794 GLSKLARIVEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQK 964
GLSK +R+++IF+RRLQ+QE LT I A+ + ++P + V + H+C+ MRGV++
Sbjct: 350 GLSKFSRVIDIFARRLQLQEDLTNDICNALGKYLKPKYLHVNLVARHLCINMRGVKE 406
>UniRef50_Q5PAR5 Cluster: GTP cyclohydrolase; n=1; Anaplasma
marginale str. St. Maries|Rep: GTP cyclohydrolase -
Anaplasma marginale (strain St. Maries)
Length = 198
Score = 113 bits (273), Expect = 6e-24
Identities = 55/173 (31%), Positives = 97/173 (56%), Gaps = 1/173 (0%)
Frame = +2
Query: 479 HRPPTREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLN 658
H+ R+ D + +L+ + + P+ GL T R A +GY
Sbjct: 2 HKDLARKPSDKDAEEAIEVLIRWIDDSPDMEGLSLTAGRVLNAYKESFQGYALESSHDFR 61
Query: 659 NAIF-DEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSR 835
N++F +E +M++++ + S CEHH+ P G V+I Y+P+ ++G+ + R+V+IF++
Sbjct: 62 NSVFANEGYSDMILLRGVNFSSTCEHHMSPMAGVVNISYIPKATVIGVGTVVRVVDIFAK 121
Query: 836 RLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSXR*RRXC 994
RLQVQER+T QIA +++ ++PAGVAV+IE H C G + ++ + + C
Sbjct: 122 RLQVQERMTVQIAQFLSELLKPAGVAVLIEAKHWCAKYLGGEAVSDLKLQTSC 174
>UniRef50_Q1FI35 Cluster: GTP cyclohydrolase I; n=1; Clostridium
phytofermentans ISDg|Rep: GTP cyclohydrolase I -
Clostridium phytofermentans ISDg
Length = 194
Score = 111 bits (268), Expect = 3e-23
Identities = 59/151 (39%), Positives = 88/151 (58%), Gaps = 8/151 (5%)
Frame = +2
Query: 536 LLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLN--NAIFDEDTDE-----MV 694
+L LGEDP R GL+ TP+R A G + ++++ N F+ED + +V
Sbjct: 15 ILIALGEDPLREGLIDTPKRVANMYEEVFLGIQYTNDDIVTMFNKCFEEDQNTFLANGIV 74
Query: 695 VVKDIEMFSMCEHHLVPFYGK-VSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQI 871
+KDIE FS CEHH+ Y ++IGY P K++G+SK+ARI ++ +RLQ+QER+ I
Sbjct: 75 WIKDIECFSFCEHHMTLIYDMHITIGYKPLHKVIGISKIARIADMVCKRLQIQERIASDI 134
Query: 872 AIAVTQAVRPAGVAVVIEGVHMCMVMRGVQK 964
+T+ + + IEG H CM RG+QK
Sbjct: 135 LEILTKITGSDDIFIKIEGKHGCMTSRGIQK 165
>UniRef50_O97071 Cluster: GTP cyclohydrolase I; n=6; Plasmodium|Rep:
GTP cyclohydrolase I - Plasmodium falciparum
Length = 389
Score = 111 bits (267), Expect = 3e-23
Identities = 51/132 (38%), Positives = 85/132 (64%), Gaps = 2/132 (1%)
Frame = +2
Query: 575 LLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDE--DTDEMVVVKDIEMFSMCEHHLVPF 748
L +T R A+ L+ T GY+ +E+++ +++ + ++ V I ++S+C+HHL+PF
Sbjct: 225 LKRTNRRYAETFLYLTNGYNLDIEQIIKRSLYKRMYKNNSIIKVTGIHIYSLCKHHLLPF 284
Query: 749 YGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEG 928
G I Y+P I+GLSK +RIV++FSRRLQ+QE LT I A+ + ++P + V I
Sbjct: 285 EGTCDIEYIPNKYIIGLSKFSRIVDVFSRRLQLQEDLTNDICNALKKYLKPLYIKVSIVA 344
Query: 929 VHMCMVMRGVQK 964
H+C+ MRGV++
Sbjct: 345 KHLCINMRGVKE 356
>UniRef50_A4CGT7 Cluster: GTP cyclohydrolase I; n=1; Robiginitalea
biformata HTCC2501|Rep: GTP cyclohydrolase I -
Robiginitalea biformata HTCC2501
Length = 176
Score = 111 bits (266), Expect = 5e-23
Identities = 60/156 (38%), Positives = 93/156 (59%), Gaps = 3/156 (1%)
Frame = +2
Query: 539 LTGLGEDPERAGLLKTPERAAKAMLFFT-KGYDQSLEEVLNNAIFDE--DTDEMVVVKDI 709
+ LG D L TP R A+ + T +G S + + F++ T EM+VV DI
Sbjct: 1 MQALGMDLSDTSLADTPMRVARMYVNETFRGL--SAKNFPRISFFEKAPGTPEMIVVNDI 58
Query: 710 EMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQ 889
++S CEHH VPF+GKV + Y+P ++LGLSK+ R+V+ SR+ +QERLT++IA +++
Sbjct: 59 TLYSYCEHHFVPFFGKVHVAYIPGDRLLGLSKVNRVVDYLSRKPHLQERLTREIADTLSE 118
Query: 890 AVRPAGVAVVIEGVHMCMVMRGVQKINSXR*RRXCW 997
++ VAV +E H+C+ RGV+ S R C+
Sbjct: 119 LLQTRHVAVFVEAQHLCVASRGVRDAKSIT-RTGCY 153
>UniRef50_A5K040 Cluster: GTP cyclohydrolase I, putative; n=1;
Plasmodium vivax|Rep: GTP cyclohydrolase I, putative -
Plasmodium vivax
Length = 423
Score = 109 bits (261), Expect = 2e-22
Identities = 52/160 (32%), Positives = 96/160 (60%), Gaps = 2/160 (1%)
Frame = +2
Query: 491 TREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIF 670
++E + ++ S +L+ P+ L +T +R L+ TKGY ++ +V+ +++
Sbjct: 218 SKETQMEAISKSINHILSSSNVPPKDI-LKRTSKRFTDTFLYLTKGYHMNVGKVIKKSLY 276
Query: 671 DED--TDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQ 844
D + + I ++S+C+HHL+PF G+ SI Y+P ++GLSK +R++ IF+RRLQ
Sbjct: 277 KRKYKNDSRIKISGIHIYSLCKHHLLPFEGECSIEYVPNRYVMGLSKFSRVINIFARRLQ 336
Query: 845 VQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQK 964
+QE LT I A+ + ++P + V + H+C+ MRGV++
Sbjct: 337 LQEDLTNDICNALRKYLKPKYIHVNVVARHLCINMRGVRE 376
>UniRef50_A6RNT4 Cluster: Putative uncharacterized protein; n=2;
Sclerotiniaceae|Rep: Putative uncharacterized protein -
Botryotinia fuckeliana B05.10
Length = 1504
Score = 107 bits (258), Expect = 4e-22
Identities = 47/90 (52%), Positives = 67/90 (74%)
Frame = +2
Query: 488 PTREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAI 667
P +A ++A + R LL +GED R GL KTPER AKA+ FFT+GY + E++N AI
Sbjct: 90 PIPQASPTEIAATIRTLLCQIGEDTNRDGLKKTPERYAKALQFFTQGYKEKSNELINGAI 149
Query: 668 FDEDTDEMVVVKDIEMFSMCEHHLVPFYGK 757
F+EDT++MV+V I++FS+CEHH++PF+GK
Sbjct: 150 FNEDTEDMVIVSGIDVFSLCEHHMLPFFGK 179
>UniRef50_Q5V5Y0 Cluster: GTP cyclohydrolase I; n=1; Haloarcula
marismortui|Rep: GTP cyclohydrolase I - Haloarcula
marismortui (Halobacterium marismortui)
Length = 210
Score = 107 bits (258), Expect = 4e-22
Identities = 58/145 (40%), Positives = 80/145 (55%), Gaps = 1/145 (0%)
Frame = +2
Query: 530 RLLLTGLGEDPERAGLLKTPERAAKAML-FFTKGYDQSLEEVLNNAIFDEDTDEMVVVKD 706
RLLL G DP+ AGL T R M T+G + ++ FD +TD ++V
Sbjct: 32 RLLLEAAGRDPDSAGLSDTWSRRVPDMFETLTEGARSESKPIMRT--FDAETDGLIVKTG 89
Query: 707 IEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVT 886
I + SMCEHH++PF G + Y P +++GLSKL R V SR+L QE LT+ IA +
Sbjct: 90 IPLHSMCEHHMLPFRGVAHVAYRPGDQMVGLSKLIRYVRWQSRQLTTQETLTRDIAAGLA 149
Query: 887 QAVRPAGVAVVIEGVHMCMVMRGVQ 961
+ GV V + HMC VMRG++
Sbjct: 150 DELDAHGVVVELTATHMCEVMRGIE 174
>UniRef50_Q6MK87 Cluster: FolE protein; n=1; Bdellovibrio
bacteriovorus|Rep: FolE protein - Bdellovibrio
bacteriovorus
Length = 242
Score = 107 bits (256), Expect = 7e-22
Identities = 60/167 (35%), Positives = 92/167 (55%), Gaps = 2/167 (1%)
Frame = +2
Query: 479 HRPPTREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLN 658
H T E + + + ++ LG D + L +TP+R AK + G ++
Sbjct: 48 HNGLTNEEKIERITEKFTDIMNTLGLDLKDDSLRETPKRVAKMYVNEVFG-GLDPKKFPK 106
Query: 659 NAIFDE--DTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFS 832
+ D + D+M+VV+ I S CEHH +P G ++ Y+P K++GLSK+ RIV+ FS
Sbjct: 107 MTVIDNKMNYDQMIVVQSIGCLSFCEHHFLPIDGFATVAYIPNKKVIGLSKINRIVQYFS 166
Query: 833 RRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINS 973
RR QVQERLTKQIA + + +AV I H C++MRG++ +S
Sbjct: 167 RRPQVQERLTKQIADCLQYILDTEHIAVHINAKHYCVMMRGIEDTSS 213
>UniRef50_Q23AG3 Cluster: GTP cyclohydrolase I family protein; n=1;
Tetrahymena thermophila SB210|Rep: GTP cyclohydrolase I
family protein - Tetrahymena thermophila SB210
Length = 223
Score = 106 bits (254), Expect = 1e-21
Identities = 59/162 (36%), Positives = 87/162 (53%), Gaps = 1/162 (0%)
Frame = +2
Query: 491 TREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLF-FTKGYDQSLEEVLNNAI 667
+ E + + + +L L D + TP R AK + +G D + +
Sbjct: 34 SNEEKIKKIEECFTEILNMLSLDQTDDSICDTPSRVAKMYINEMFQGLDYANFPDMTTID 93
Query: 668 FDEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQV 847
+ +EMV ++DI + + CEHH + F G ++ Y+P+ K+LGLSK+ R+V FS+R QV
Sbjct: 94 NKMEYNEMVQIQDIALTTTCEHHFITFDGFATVAYIPKDKVLGLSKINRLVRFFSKRPQV 153
Query: 848 QERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINS 973
QERLTKQI +A+ V VAV I VH C+ RGV NS
Sbjct: 154 QERLTKQILVALQTIVETEDVAVHINAVHFCVKARGVMDQNS 195
>UniRef50_UPI00015BB290 Cluster: GTP cyclohydrolase; n=1; Ignicoccus
hospitalis KIN4/I|Rep: GTP cyclohydrolase - Ignicoccus
hospitalis KIN4/I
Length = 186
Score = 101 bits (242), Expect = 4e-20
Identities = 54/143 (37%), Positives = 86/143 (60%), Gaps = 2/143 (1%)
Frame = +2
Query: 539 LTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLN-NAIFDEDTDEMVVVKDIEM 715
L +GEDP R GL +TPER +A+ KG + E+ + ++++VVK++
Sbjct: 14 LEEMGEDPSRPGLSETPERYVRALRELFKGLETPKPELKTFKTEYLLGENDLIVVKNVSF 73
Query: 716 FSMCEHHLVPFYGKVSIGYLP-QGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQA 892
S+CEHHL+P G+ SI Y P + +++GLSK+ RIV+ ++R +QER T IA + +A
Sbjct: 74 SSLCEHHLLPILGRASIVYHPKRDEVIGLSKIPRIVKWLAKRPMLQERFTAMIADEIMKA 133
Query: 893 VRPAGVAVVIEGVHMCMVMRGVQ 961
GV V++ H C+ +RGV+
Sbjct: 134 -GARGVYVLVRAKHSCVAVRGVE 155
>UniRef50_Q8ZG15 Cluster: GTP cyclohydrolase I; n=129; root|Rep: GTP
cyclohydrolase I - Yersinia pestis
Length = 220
Score = 101 bits (241), Expect = 5e-20
Identities = 46/97 (47%), Positives = 66/97 (68%)
Frame = +2
Query: 683 DEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLT 862
DEMV V+DI + S CEHH V GK ++ Y+P+ ++GLSK+ RIV+ F++R QVQERLT
Sbjct: 95 DEMVTVRDITLTSTCEHHFVTIDGKATVAYIPKDSVIGLSKINRIVQFFAQRPQVQERLT 154
Query: 863 KQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINS 973
+QI +A+ + VAV I+ VH C+ RG++ S
Sbjct: 155 QQILLALQTLLGTNNVAVSIDAVHYCVKARGIRDATS 191
>UniRef50_Q19Z80 Cluster: Gp6; n=4; root|Rep: Gp6 - Mycobacterium
phage Qyrzula
Length = 191
Score = 100 bits (240), Expect = 6e-20
Identities = 51/132 (38%), Positives = 77/132 (58%), Gaps = 2/132 (1%)
Frame = +2
Query: 584 TPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKDIEMFSMCEHHLVPFYGKVS 763
TP R+AKA GY + + L D V++ +++ SMC HHL+PF G +
Sbjct: 29 TPLRSAKAWSDILSGYREDPADHLEVTFSAPDDPGQVILAGVQLQSMCAHHLLPFTGMAT 88
Query: 764 IGYLPQ--GKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHM 937
+ Y P +++GLSKL+R+V+ ++RRLQVQER+ A+ +RPAG V+I H
Sbjct: 89 VAYRPSPGDRVVGLSKLSRVVQGYARRLQVQERIGADTVDAIMARLRPAGAVVLITASHD 148
Query: 938 CMVMRGVQKINS 973
CM +RG Q+ +S
Sbjct: 149 CMRLRGAQEPHS 160
>UniRef50_Q8ZWW5 Cluster: GTP cyclohydrolase I; n=4;
Pyrobaculum|Rep: GTP cyclohydrolase I - Pyrobaculum
aerophilum
Length = 187
Score = 100 bits (240), Expect = 6e-20
Identities = 55/142 (38%), Positives = 86/142 (60%)
Frame = +2
Query: 536 LLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKDIEM 715
LL LGED + G+L TP+R KAM T+G + EV+ + + VV+++I
Sbjct: 18 LLEYLGEDLTKPGVLNTPKRFVKAMEELTRGLREPPPEVVFFPLEYDVELGPVVIENIGA 77
Query: 716 FSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQAV 895
S+CEHHL+P ++S+ Y+P + GLSK+ R+V+ + R +QER T+ +A + + +
Sbjct: 78 VSLCEHHLLPILLRISVAYVPGDGVPGLSKVIRLVKWAAARPIMQERFTEWLADLLMEKL 137
Query: 896 RPAGVAVVIEGVHMCMVMRGVQ 961
R GV V + GVHMC +RGV+
Sbjct: 138 RAKGVQVKVCGVHMCSFIRGVK 159
>UniRef50_Q7XM20 Cluster: OSJNBa0084K01.11 protein; n=4; Oryza
sativa|Rep: OSJNBa0084K01.11 protein - Oryza sativa
subsp. japonica (Rice)
Length = 451
Score = 99 bits (238), Expect = 1e-19
Identities = 61/165 (36%), Positives = 94/165 (56%), Gaps = 11/165 (6%)
Frame = +2
Query: 512 DMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTK-GYDQSLEE-VLNN-AIFD--- 673
+M ++ +L LGEDP R L+ TP+R + ++ F D L LNN +++
Sbjct: 255 NMVSAVSSMLLSLGEDPFRKELVGTPQRYVQWLMKFRACNLDVKLNGFTLNNLSVYQSPA 314
Query: 674 -EDTDEMVVVKDIEM--FSMCEHHLVPFYGKVSIGYLP--QGKILGLSKLARIVEIFSRR 838
+ D + ++ + + CEHHL+PFYG V IGYL G+++ S +V + +
Sbjct: 315 GDAADHRAIHSELHLPFCAQCEHHLLPFYGVVHIGYLDGGDGEVIDRSHFQALVHFYGCK 374
Query: 839 LQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINS 973
LQVQER+T+QIA AV +V G VV+E H+CM+ RG++KI S
Sbjct: 375 LQVQERMTRQIAEAV-YSVSHCGAIVVVEANHICMISRGIEKIRS 418
Score = 61.3 bits (142), Expect = 5e-08
Identities = 35/106 (33%), Positives = 64/106 (60%), Gaps = 1/106 (0%)
Frame = +2
Query: 623 KGYDQSLEEVLNNAIFDEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQG-KILGL 799
KGY Q + +++ A+F E V D S + + F+ +GY+P G +++GL
Sbjct: 67 KGYMQKVRDIVPVALFPE------VGVDQRTGSCWRNWSIQFH----VGYVPSGGRVVGL 116
Query: 800 SKLARIVEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHM 937
SKL+R+ ++F++RLQ +RL ++ A+ +++PAGVAV ++ H+
Sbjct: 117 SKLSRVADVFAKRLQNPQRLASEVCGALHASIQPAGVAVALQCWHI 162
>UniRef50_Q6ME26 Cluster: Probable GTP cyclohydrolase I; n=1;
Candidatus Protochlamydia amoebophila UWE25|Rep:
Probable GTP cyclohydrolase I - Protochlamydia
amoebophila (strain UWE25)
Length = 224
Score = 97.1 bits (231), Expect = 8e-19
Identities = 54/153 (35%), Positives = 85/153 (55%), Gaps = 4/153 (2%)
Frame = +2
Query: 515 MANSYRLLLTGLGEDPERAGLLKTPERAAKAML--FFTKGYDQSLEEV--LNNAIFDEDT 682
+A ++ ++ L D E L +TPER AK + F+ +++ E+ + I E
Sbjct: 38 IAEHFKAIMETLELDVEDESLARTPERVAKMYVNEIFSGLDEENFPEISFFKDEIHHEHK 97
Query: 683 DEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLT 862
MV VK + S CEHH VP G + Y+P +++GLSK+ R+V F++R Q+QERLT
Sbjct: 98 ANMVFVK-VGFTSFCEHHFVPMSGFAYVAYIPTNQLIGLSKIPRLVRYFAKRPQLQERLT 156
Query: 863 KQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQ 961
QIA ++ + VAV + +H C+ RG+Q
Sbjct: 157 AQIADSLALLLNTEHVAVSLTAIHSCVQARGIQ 189
>UniRef50_A3J0S0 Cluster: GTP cyclohydrolase I; n=28;
Bacteroidetes|Rep: GTP cyclohydrolase I - Flavobacteria
bacterium BAL38
Length = 249
Score = 97.1 bits (231), Expect = 8e-19
Identities = 55/152 (36%), Positives = 85/152 (55%), Gaps = 3/152 (1%)
Frame = +2
Query: 527 YRLLLTGLGEDPERAGLLKTPERAAKAMLF-FTKGYDQSLEEVLNNAIFDEDT--DEMVV 697
+ +++ LG D L TP R AK + G + + + ++ +FD D+M+V
Sbjct: 73 FEIIMKELGLDLTDDSLQGTPHRVAKMFVQEIFSGLNPANKPKIS--VFDNSYQYDKMLV 130
Query: 698 VKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAI 877
+I S CEHH +P GK IGY+ GK++GLSKL RIV+ ++RR QVQER+ QI
Sbjct: 131 EANISFNSTCEHHFLPIVGKAHIGYVSSGKVIGLSKLNRIVDYYARRPQVQERMIMQIFN 190
Query: 878 AVTQAVRPAGVAVVIEGVHMCMVMRGVQKINS 973
+ + V VV+E H+C+ RG++ +S
Sbjct: 191 ELKTVLETDNVMVVMEATHLCVSSRGIKDESS 222
>UniRef50_Q54768 Cluster: Putative uncharacterized protein; n=1;
Synechococcus elongatus PCC 7942|Rep: Putative
uncharacterized protein - Synechococcus sp. (strain PCC
7942) (Anacystis nidulans R2)
Length = 227
Score = 96.7 bits (230), Expect = 1e-18
Identities = 48/133 (36%), Positives = 69/133 (51%)
Frame = -1
Query: 964 LLDSSHHHAHVNSFNDDRHAGRAYGLCHRDGYLLRQTFLYLKTAGEYFHDPGQFAETQNF 785
LLD++HHHAHV F+DD H R HR L Q L+L+TA + D QFA+ N
Sbjct: 43 LLDTAHHHAHVGGFHDDGHTLRVEDFLHRLSNLAGQALLHLQTATVHLDDASQFAQADNL 102
Query: 784 SLWQVPDGDLSVKRHQMMFAH*KHLDILNDHHLVRVFIEDGVVQNLFQALVVSFREEEHS 605
+ V D + + +R ++F + D+ + HH V F+EDG V + Q L V+ ++
Sbjct: 103 LVGDVSDVNFAHERQHVVFTKAEGGDVTHQHHFVVTFVEDGAVDQVIQGLAVAAGQKAIG 162
Query: 604 FGGTFGRLQEPCP 566
F QEP P
Sbjct: 163 LSDPFRGFQEPFP 175
>UniRef50_UPI000038E307 Cluster: hypothetical protein Faci_03001748;
n=1; Ferroplasma acidarmanus fer1|Rep: hypothetical
protein Faci_03001748 - Ferroplasma acidarmanus fer1
Length = 191
Score = 93.9 bits (223), Expect = 7e-18
Identities = 43/96 (44%), Positives = 64/96 (66%), Gaps = 2/96 (2%)
Frame = +2
Query: 683 DEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQ--GKILGLSKLARIVEIFSRRLQVQER 856
+ MV+VK+I +SMC HHL+PF+G ++I YLP+ G I G+SKL R V + + Q+QE
Sbjct: 63 ESMVIVKNISFYSMCSHHLLPFFGNINIAYLPRPAGYIAGVSKLVRSVNKIASKPQLQEN 122
Query: 857 LTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQK 964
+T +I + + P V V +G HMCM+MRGV++
Sbjct: 123 MTSEIVNLLYDNLNPLFVMVTAKGQHMCMMMRGVKQ 158
>UniRef50_Q7N3C4 Cluster: Similarities with GTP cyclohydrolase I;
n=1; Photorhabdus luminescens subsp. laumondii|Rep:
Similarities with GTP cyclohydrolase I - Photorhabdus
luminescens subsp. laumondii
Length = 234
Score = 85.0 bits (201), Expect = 3e-15
Identities = 63/159 (39%), Positives = 85/159 (53%), Gaps = 6/159 (3%)
Frame = +2
Query: 503 LLPDMANSYRLLLTGLGEDPERAGLLK-TPERAAKA-MLFFTKGYDQSLEEVLNNAIFDE 676
++ + A S+ LT LG D + K TP R AKA +L KG + + + F
Sbjct: 45 IIDEAAISFGEFLTALGVDWKNDPNSKDTPRRVAKAYVLDLWKGRYKPMGPITT---FPA 101
Query: 677 DTDEMVVVKD-IEMFSMCEHHLVPFYGKVSIGYLPQ--GKILGLSKLARIVEIFSRRLQV 847
D + +V I + SMC HH G V + Y+P G++LGLSKL RIVE F RR +
Sbjct: 102 DNYDGIVFDGWIALDSMCSHHHQAISGYVHVAYMPSQYGRVLGLSKLNRIVEHFGRRGLI 161
Query: 848 QERLTKQIAIAVTQAV-RPAGVAVVIEGVHMCMVMRGVQ 961
QERLT I AV Q R GVAV+++ H C+ RGV+
Sbjct: 162 QERLTAAIHNAVNQVCERNQGVAVLVDASHNCVRCRGVR 200
>UniRef50_Q2GDH9 Cluster: GTP cyclohydrolase I; n=1; Neorickettsia
sennetsu str. Miyayama|Rep: GTP cyclohydrolase I -
Neorickettsia sennetsu (strain Miyayama)
Length = 180
Score = 83.8 bits (198), Expect = 8e-15
Identities = 47/134 (35%), Positives = 70/134 (52%), Gaps = 1/134 (0%)
Frame = +2
Query: 545 GLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDE-MVVVKDIEMFS 721
G+GE +R G K + GY S L + + D E ++V+K S
Sbjct: 16 GVGET-DRLGARGASHSFLKMFANYFSGYACSDFSSLVAKMENPDGGESLLVLKRTPFLS 74
Query: 722 MCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQAVRP 901
CEHH++P G +SIGY+P I L L R+V ++RLQ+QER+ QIA+A+ +++ P
Sbjct: 75 FCEHHVLPISGYISIGYIPDKSITSLGSLGRLVSACTKRLQLQERICAQIALAIEESLSP 134
Query: 902 AGVAVVIEGVHMCM 943
GV V H C+
Sbjct: 135 KGVIVYASAKHACV 148
>UniRef50_Q08SR8 Cluster: GTP cyclohydrolase I 2; n=2;
Cystobacterineae|Rep: GTP cyclohydrolase I 2 -
Stigmatella aurantiaca DW4/3-1
Length = 153
Score = 83.4 bits (197), Expect = 1e-14
Identities = 40/121 (33%), Positives = 66/121 (54%), Gaps = 2/121 (1%)
Frame = +2
Query: 608 MLFFTKGYDQSLEEVLNNAIF--DEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQ 781
M F GY + EE + + EMVVV D+ SMC HHL+P+ G+ + Y+P
Sbjct: 1 MTEFLDGYALTPEEAIGTVYPAPPDSAGEMVVVTDLRFHSMCPHHLLPYEGRAHVAYVPG 60
Query: 782 GKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQ 961
++G +L+ +V+ F+ RL +QE L + +A A+ + + A ++E CM +RG Q
Sbjct: 61 KHVVGFGRLSTLVDCFAHRLILQEDLARHVASALARVLGSPATACILEAKQACMRLRGEQ 120
Query: 962 K 964
+
Sbjct: 121 Q 121
>UniRef50_Q8XZK8 Cluster: GTP cyclohydrolase I; n=29;
Betaproteobacteria|Rep: GTP cyclohydrolase I - Ralstonia
solanacearum (Pseudomonas solanacearum)
Length = 209
Score = 83.0 bits (196), Expect = 1e-14
Identities = 43/139 (30%), Positives = 74/139 (53%), Gaps = 1/139 (0%)
Frame = +2
Query: 536 LLTGLGEDPERAGLLKTPERAAKA-MLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKDIE 712
LL G + + A KT +R + GYD E L + F++ +MV+++ I
Sbjct: 37 LLEASGIEIDTAHTGKTAQRVRELWQRRLLDGYDIDPAEALGHG-FEDPRRDMVIIRSIA 95
Query: 713 MFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQA 892
+ +C HHL+PF G + YLP G++ G ++AR+++ S R QE +T ++A A+
Sbjct: 96 VHGVCPHHLLPFRGVAHVAYLPDGRLHGFGRIARMIDAISHRYTYQEWVTNEVAHALVAH 155
Query: 893 VRPAGVAVVIEGVHMCMVM 949
+ G A +IE +C++M
Sbjct: 156 GQARGAACLIEAEQLCLLM 174
>UniRef50_A7HBJ5 Cluster: GTP cyclohydrolase I; n=2;
Anaeromyxobacter|Rep: GTP cyclohydrolase I -
Anaeromyxobacter sp. Fw109-5
Length = 219
Score = 82.6 bits (195), Expect = 2e-14
Identities = 55/164 (33%), Positives = 82/164 (50%), Gaps = 4/164 (2%)
Frame = +2
Query: 518 ANSYRLLLTGLGEDPE-RAG--LLKTPERAAKAMLF-FTKGYDQSLEEVLNNAIFDEDTD 685
A + L LG P+ RA L T R A+A L GY + E+L +AI D
Sbjct: 24 AEAVERFLDALGLPPQVRASPDLQGTHRRVAQAWLEDLVDGYRRDPAEILADAIPSPSRD 83
Query: 686 EMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTK 865
+V V I S+C HHL+P G + YLP G+++G +L R+V+ + RL +QE L
Sbjct: 84 -LVAVTGIAFHSVCPHHLLPSRGVAHVAYLPGGRVVGFGQLVRLVDALAHRLVLQEDLAH 142
Query: 866 QIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSXR*RRXCW 997
IA A+ + G A +++ +CM +RG +K + R W
Sbjct: 143 GIADALVTHLGARGAACLLDAEQLCMTVRG-EKRGAARAHADAW 185
>UniRef50_A4SVK2 Cluster: GTP cyclohydrolase I; n=20; Bacteria|Rep:
GTP cyclohydrolase I - Polynucleobacter sp. QLW-P1DMWA-1
Length = 262
Score = 80.2 bits (189), Expect = 1e-13
Identities = 55/203 (27%), Positives = 96/203 (47%), Gaps = 5/203 (2%)
Frame = +2
Query: 380 ESELEVPGTPMTPRTSTTPGHENCTFHHDLELDH--RPPTREALLPDMANSYRLLLTGLG 553
+S+ + G P++ +N FH + + +P E L+ ++A + +L L
Sbjct: 32 QSKNDDAGLPLSVMIRRRIEAQNARFHANDNISAFIKPGELEGLVDEVAEKMQAVLESLV 91
Query: 554 EDPERAGLLKTPERAAKAMLFFTKGYDQSLEE-VLNNAIFDEDTDEMVVVKDIEMFSMCE 730
D K R M + +E+ L +E+++V I + S C
Sbjct: 92 IDTNSDHNTKNTSRRVAKMYVQEVFNGRYVEQPTLTKFPNVSRLNELMIVGPITIRSACS 151
Query: 731 HHLVPFYGKVSIGYLP--QGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQAVRPA 904
HHL P G++ IG LP + ++GLSK +R+ E R Q+QE ++A + + ++P
Sbjct: 152 HHLCPIMGRIWIGVLPSKESALIGLSKYSRLTEWVMCRPQIQEEAVVELADMLEKKIKPI 211
Query: 905 GVAVVIEGVHMCMVMRGVQKINS 973
GVA+V++ H CM RGV+ +S
Sbjct: 212 GVAIVMDADHFCMQWRGVKDRDS 234
>UniRef50_A5GUC6 Cluster: GTP cyclohydrolase I; n=28;
Cyanobacteria|Rep: GTP cyclohydrolase I - Synechococcus
sp. (strain RCC307)
Length = 262
Score = 79.8 bits (188), Expect = 1e-13
Identities = 54/167 (32%), Positives = 82/167 (49%), Gaps = 4/167 (2%)
Frame = +2
Query: 476 DH-RPPTREALLPDMANSYRLLLTGLGEDPERA-GLLKTPERAAKAMLFFTKGYDQSLEE 649
DH +P E L ++ + R LL L D ER +T ER AK ++ + + E
Sbjct: 62 DHLKPGELELLQQEVTDKVRDLLRSLVIDIERDHNTEETAERVAK--MYLQEVFKGRYLE 119
Query: 650 VLNNAIFD--EDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVE 823
A F ++ DE+ V I + S C HHLVP G IG P ++GLSK AR+ +
Sbjct: 120 QPKIASFPNVKNLDEIYTVGPITVRSACSHHLVPILGNCWIGIKPGSSVIGLSKFARVAD 179
Query: 824 IFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQK 964
R +QE +A + + P G+A++++ H CM RGV++
Sbjct: 180 WVFSRPHIQEEAVMILADEIERLCEPKGLAILVKAQHYCMKWRGVKE 226
>UniRef50_A7JLM6 Cluster: GTP cyclohydrolase I; n=11; Francisella
tularensis|Rep: GTP cyclohydrolase I - Francisella
tularensis subsp. novicida GA99-3548
Length = 207
Score = 79.0 bits (186), Expect = 2e-13
Identities = 52/158 (32%), Positives = 83/158 (52%), Gaps = 5/158 (3%)
Frame = +2
Query: 515 MANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLE--EVLNNAIFDEDTDE 688
+ +YR +L LG + KTP R A+ FT+ L+ A+++ + +
Sbjct: 42 ITKAYRQILDALGLYTDE--FEKTPFRVAR---MFTQEIFNGLDYANFPACALYENEFNY 96
Query: 689 MVVV--KDIEMFSMCEHHLVPFYGKVSIGYLPQGK-ILGLSKLARIVEIFSRRLQVQERL 859
V+ K+I + S CEHH VPF G + ++P+ I+GL ++ I + FSRR Q+QER+
Sbjct: 97 TGVLTQKNITIMSFCEHHFVPFEGTAEVSFIPKNNNIIGLCRINSICDFFSRRPQIQERM 156
Query: 860 TKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINS 973
T QI + + V+V I+ H C+ +RGV NS
Sbjct: 157 TAQIFETLKFILSTEDVSVKIKAKHACVSLRGVNNQNS 194
>UniRef50_Q83FV8 Cluster: GTP cyclohydrolase I; n=2; Tropheryma
whipplei|Rep: GTP cyclohydrolase I - Tropheryma whipplei
(strain Twist) (Whipple's bacillus)
Length = 181
Score = 76.6 bits (180), Expect = 1e-12
Identities = 46/137 (33%), Positives = 74/137 (54%)
Frame = +2
Query: 536 LLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKDIEM 715
LL+ LG+D R L +TP A+ + G + + + L + I + +V+++DI
Sbjct: 19 LLSALGQDVGR--LKETPSIASSGLESLISGSETNPADCLVDLIPNTQKG-IVILRDIPF 75
Query: 716 FSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQAV 895
S+CEHHL+PF G ++ Y P + GL L +V +RRL +QER+T QIA A+ +
Sbjct: 76 RSICEHHLLPFVGTANLLYEPGKFLAGLGNLTSLVRCAARRLSIQERVTDQIADAIYTGL 135
Query: 896 RPAGVAVVIEGVHMCMV 946
V V + H C++
Sbjct: 136 CARRVLVSLAARHTCIL 152
>UniRef50_UPI0000F1DBDC Cluster: PREDICTED: similar to GTP
cyclohydrolase I (form A; N-terminus), partial; n=1;
Danio rerio|Rep: PREDICTED: similar to GTP
cyclohydrolase I (form A; N-terminus), partial - Danio
rerio
Length = 115
Score = 65.7 bits (153), Expect = 2e-09
Identities = 30/49 (61%), Positives = 36/49 (73%)
Frame = +2
Query: 497 EALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSL 643
E LP +A +Y +L GLGEDP+R GLLKTP RAA AM FFTKGY + +
Sbjct: 66 EMSLPSIAAAYTTILRGLGEDPQRQGLLKTPWRAATAMQFFTKGYQEKI 114
>UniRef50_A0YW77 Cluster: GTP cyclohydrolase I; n=1; Lyngbya sp. PCC
8106|Rep: GTP cyclohydrolase I - Lyngbya sp. PCC 8106
Length = 62
Score = 39.1 bits (87), Expect = 0.22
Identities = 25/66 (37%), Positives = 34/66 (51%)
Frame = +2
Query: 410 MTPRTSTTPGHENCTFHHDLELDHRPPTREALLPDMANSYRLLLTGLGEDPERAGLLKTP 589
MT S+ G+ N + L+ P E +M + R LL GLGE+P+R GL TP
Sbjct: 1 MTLANSSPKGNPNGNLPN-LKTQSELPVSEE---EMRQAVRTLLLGLGENPDREGLKDTP 56
Query: 590 ERAAKA 607
+R KA
Sbjct: 57 KRVVKA 62
>UniRef50_Q9WZP8 Cluster: NADPH-dependent 7-cyano-7-deazaguanine
reductase (EC 1.7.1.13) (7- cyano-7-carbaguanine
reductase) (PreQ(0) reductase); n=3; Thermotogaceae|Rep:
NADPH-dependent 7-cyano-7-deazaguanine reductase (EC
1.7.1.13) (7- cyano-7-carbaguanine reductase) (PreQ(0)
reductase) - Thermotoga maritima
Length = 137
Score = 38.3 bits (85), Expect = 0.39
Identities = 29/92 (31%), Positives = 42/92 (45%), Gaps = 1/92 (1%)
Frame = +2
Query: 599 AKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLP 778
A+ +F KG+D + L FD DE + ++ E ++C +P G+V I Y P
Sbjct: 4 AEGRIFDFKGHDAIRTDFLEAIDFD-GKDEYIKIETDEFSAVCPFSGLPDIGRVIIEYYP 62
Query: 779 Q-GKILGLSKLARIVEIFSRRLQVQERLTKQI 871
GKI+ L L F QE TK+I
Sbjct: 63 DGGKIVELKSLKYYFVSFRNVGIYQEEATKRI 94
>UniRef50_Q7NR63 Cluster: Acetylglutamate kinase; n=3; Bacteria|Rep:
Acetylglutamate kinase - Chromobacterium violaceum
Length = 289
Score = 38.3 bits (85), Expect = 0.39
Identities = 17/42 (40%), Positives = 26/42 (61%)
Frame = -1
Query: 916 DRHAGRAYGLCHRDGYLLRQTFLYLKTAGEYFHDPGQFAETQ 791
++H G+A GL +DG+ +R L+LKT G+ D GQ E +
Sbjct: 114 NKHGGKAVGLTGKDGHFIRARKLFLKTDGDEDVDIGQVGEIE 155
>UniRef50_A6GIP6 Cluster: Putative uncharacterized protein; n=1;
Plesiocystis pacifica SIR-1|Rep: Putative
uncharacterized protein - Plesiocystis pacifica SIR-1
Length = 207
Score = 36.3 bits (80), Expect = 1.6
Identities = 24/80 (30%), Positives = 37/80 (46%)
Frame = -1
Query: 889 LCHRDGYLLRQTFLYLKTAGEYFHDPGQFAETQNFSLWQVPDGDLSVKRHQMMFAH*KHL 710
L R G ++ L + AGE H+ + E QV G L+ H+++ AH
Sbjct: 13 LHERVGDVVADPLLEGQPAGEAVHELAEPTEADQLVRGQVGHGRLAHPGHEVVRAHPVAR 72
Query: 709 DILNDHHLVRVFIEDGVVQN 650
D+ +DH L EDGV ++
Sbjct: 73 DVPHDHELRVPLAEDGVAED 92
>UniRef50_Q5AW97 Cluster: Putative uncharacterized protein; n=1;
Emericella nidulans|Rep: Putative uncharacterized
protein - Emericella nidulans (Aspergillus nidulans)
Length = 643
Score = 34.7 bits (76), Expect = 4.8
Identities = 21/60 (35%), Positives = 29/60 (48%)
Frame = +2
Query: 335 KKAPEALKXFNLADAESELEVPGTPMTPRTSTTPGHENCTFHHDLELDHRPPTREALLPD 514
++ P+A K AD E ++P P T +ST H +L + PTREAL PD
Sbjct: 407 RRFPKA-KLVTKADVEVAEDMPTRPSTGVSSTLKSFRKSRHGHCQQLKQQEPTREALPPD 465
>UniRef50_Q4EE10 Cluster: GTP cyclohydrolase I; n=1; Listeria
monocytogenes str. 4b H7858|Rep: GTP cyclohydrolase I -
Listeria monocytogenes str. 4b H7858
Length = 86
Score = 34.3 bits (75), Expect = 6.3
Identities = 13/30 (43%), Positives = 23/30 (76%)
Frame = +2
Query: 515 MANSYRLLLTGLGEDPERAGLLKTPERAAK 604
+A++ +++L +GE+PER GL+ TP R A+
Sbjct: 30 IADAVKVILEAVGENPEREGLIDTPMRVAR 59
>UniRef50_A6RXW6 Cluster: Putative uncharacterized protein; n=1;
Botryotinia fuckeliana B05.10|Rep: Putative
uncharacterized protein - Botryotinia fuckeliana B05.10
Length = 1213
Score = 34.3 bits (75), Expect = 6.3
Identities = 16/49 (32%), Positives = 26/49 (53%)
Frame = +2
Query: 335 KKAPEALKXFNLADAESELEVPGTPMTPRTSTTPGHENCTFHHDLELDH 481
+KAPEAL N + +P TP +PR+ + HH++E+D+
Sbjct: 127 QKAPEALTVSNYPLSPKNTSIPNTP-SPRSEANDKINSIITHHEIEIDN 174
>UniRef50_Q5FLA3 Cluster: Negative regulator genetic competence;
n=1; Lactobacillus acidophilus|Rep: Negative regulator
genetic competence - Lactobacillus acidophilus
Length = 246
Score = 33.9 bits (74), Expect = 8.3
Identities = 23/80 (28%), Positives = 34/80 (42%)
Frame = +2
Query: 509 PDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDE 688
PD AN+ R +++GLG+D + T E FF L+ L+ D+D D
Sbjct: 80 PDEANNLRQMMSGLGDDDNQ-----TQEEPDSRRSFFDLDPKDDLDAQLDQDDEDKDLDA 134
Query: 689 MVVVKDIEMFSMCEHHLVPF 748
DIE + + H F
Sbjct: 135 NEDASDIEYWKFQKRHAYSF 154
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 976,995,954
Number of Sequences: 1657284
Number of extensions: 21068573
Number of successful extensions: 59981
Number of sequences better than 10.0: 89
Number of HSP's better than 10.0 without gapping: 56264
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 59780
length of database: 575,637,011
effective HSP length: 102
effective length of database: 406,594,043
effective search space used: 119538648642
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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