Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fdpeP20_F_B21
(920 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P26267 Cluster: Pyruvate dehydrogenase E1 component sub... 143 6e-33
UniRef50_UPI0000E4A5CB Cluster: PREDICTED: hypothetical protein,... 139 1e-31
UniRef50_Q9W4H4 Cluster: CG7024-PA; n=2; Sophophora|Rep: CG7024-... 137 4e-31
UniRef50_P08559 Cluster: Pyruvate dehydrogenase E1 component sub... 126 1e-27
UniRef50_Q6NX32 Cluster: Pyruvate dehydrogenase (Lipoamide) alph... 120 5e-26
UniRef50_P16387 Cluster: Pyruvate dehydrogenase E1 component sub... 106 9e-22
UniRef50_Q23KL2 Cluster: Pyruvate dehydrogenase E1 component; n=... 101 2e-20
UniRef50_Q8H1Y0 Cluster: Pyruvate dehydrogenase E1 component sub... 100 1e-19
UniRef50_A2QWB4 Cluster: Catalytic activity: Pyruvate + Lipoamid... 97 6e-19
UniRef50_Q9R9N5 Cluster: Pyruvate dehydrogenase E1 component sub... 94 5e-18
UniRef50_Q4T3C0 Cluster: Chromosome undetermined SCAF10102, whol... 91 4e-17
UniRef50_Q1EGI2 Cluster: Pyruvate dehydrogenase E1 alpha subunit... 91 5e-17
UniRef50_O96865 Cluster: Pyruvate dehydrogenase E1 alpha subunit... 90 6e-17
UniRef50_Q4WHM5 Cluster: Pyruvate dehydrogenase E1 component alp... 89 2e-16
UniRef50_O66112 Cluster: Pyruvate dehydrogenase E1 component sub... 87 8e-16
UniRef50_Q8SQM8 Cluster: PYRUVATE DEHYDROGENASE E1 COMPONENT ALP... 85 2e-15
UniRef50_Q4QDQ1 Cluster: Pyruvate dehydrogenase E1 component alp... 84 6e-15
UniRef50_A7CXZ4 Cluster: Pyruvate dehydrogenase; n=1; Opitutacea... 82 2e-14
UniRef50_A6DTS3 Cluster: Dehydrogenase complex, E1 component, al... 79 1e-13
UniRef50_Q2S150 Cluster: Pyruvate dehydrogenase E1 component, al... 79 2e-13
UniRef50_Q5FNM5 Cluster: Pyruvate dehydrogenase E1 component alp... 78 4e-13
UniRef50_Q95VS6 Cluster: Pyruvate dehydrogenase E1 alpha subunit... 72 2e-11
UniRef50_Q1ATM5 Cluster: Pyruvate dehydrogenase; n=1; Rubrobacte... 72 2e-11
UniRef50_Q12FH4 Cluster: Pyruvate dehydrogenase; n=37; Bacteria|... 72 2e-11
UniRef50_Q1EGH8 Cluster: Pyruvate dehydrogenase E1 alpha subunit... 71 6e-11
UniRef50_Q9Z8N4 Cluster: Pyruvate Dehydrogenase Alpha; n=8; Chla... 69 1e-10
UniRef50_Q74AD3 Cluster: Dehydrogenase complex, E1 component, al... 69 2e-10
UniRef50_A5UU15 Cluster: Pyruvate dehydrogenase; n=3; Chloroflex... 66 1e-09
UniRef50_A0LSF3 Cluster: Pyruvate dehydrogenase; n=5; Bacteria|R... 65 3e-09
UniRef50_Q2ITF8 Cluster: Acetoin dehydrogenase (TPP-dependent) a... 60 1e-07
UniRef50_Q1KSF1 Cluster: Apicoplast pyruvate dehydrogenase E1 al... 59 1e-07
UniRef50_Q6MAE2 Cluster: Putative pyruvate dehydrogenase (Lipoam... 59 2e-07
UniRef50_Q1XDM0 Cluster: Pyruvate dehydrogenase E1 component sub... 58 3e-07
UniRef50_Q3J9C5 Cluster: Dehydrogenase, E1 component; n=3; Prote... 57 6e-07
UniRef50_A6GG24 Cluster: Pyruvate dehydrogenase (Lipoamide), alp... 56 1e-06
UniRef50_A7BPK6 Cluster: Pyruvate dehydrogenase; n=1; Beggiatoa ... 56 1e-06
UniRef50_Q28MR4 Cluster: Dehydrogenase E1 component; n=8; Bacter... 54 4e-06
UniRef50_Q13GQ3 Cluster: Putative 2-oxo acid dehydrogenase alpha... 54 4e-06
UniRef50_Q5VGY4 Cluster: Pyruvate dehydrogenase alpha subunit; n... 54 4e-06
UniRef50_Q1ARM0 Cluster: Pyruvate dehydrogenase; n=3; Bacteria|R... 54 5e-06
UniRef50_A0HHH5 Cluster: Dehydrogenase, E1 component; n=2; Bacte... 54 5e-06
UniRef50_Q7V0M7 Cluster: Dehydrogenase, E1 component; n=1; Proch... 53 9e-06
UniRef50_A3VIE7 Cluster: Tpp-dependent acetoin dehydrogenase e1 ... 53 9e-06
UniRef50_A6Q3I6 Cluster: Pyruvate/2-oxoglutarate dehydrogenase c... 53 1e-05
UniRef50_A5V557 Cluster: Pyruvate dehydrogenase; n=1; Sphingomon... 52 3e-05
UniRef50_P27745 Cluster: Acetoin:2,6-dichlorophenolindophenol ox... 51 4e-05
UniRef50_A5V540 Cluster: Dehydrogenase, E1 component; n=3; Prote... 50 8e-05
UniRef50_A4AFX0 Cluster: Acetoin dehydrogenase (TPP-dependent) a... 50 1e-04
UniRef50_A4X7T3 Cluster: Dehydrogenase, E1 component; n=3; Actin... 48 3e-04
UniRef50_A3CMZ3 Cluster: Pyruvate dehydrogenase, TPP-dependent E... 47 6e-04
UniRef50_Q18CB6 Cluster: Acetoin:2,6-dichlorophenolindophenol ox... 46 0.001
UniRef50_Q2WB98 Cluster: Pyruvate/2-oxoglutarate dehydrogenase c... 46 0.002
UniRef50_Q3DZ88 Cluster: Dehydrogenase, E1 component; n=1; Chlor... 46 0.002
UniRef50_A0UXT3 Cluster: Pyruvate dehydrogenase; n=1; Clostridiu... 45 0.002
UniRef50_A0LFE6 Cluster: Pyruvate dehydrogenase; n=1; Syntrophob... 44 0.005
UniRef50_Q00TN9 Cluster: Pyruvate dehydrogenase E1 component bet... 42 0.017
UniRef50_A5V4J0 Cluster: Pyruvate dehydrogenase; n=2; Sphingomon... 42 0.022
UniRef50_A4VXG8 Cluster: Pyruvate/2-oxoglutarate dehydrogenase c... 42 0.022
UniRef50_Q2BFQ9 Cluster: Putative uncharacterized protein; n=1; ... 42 0.029
UniRef50_Q479Q2 Cluster: Dehydrogenase, E1 component; n=2; Rhodo... 41 0.039
UniRef50_Q0LRY7 Cluster: Dehydrogenase, E1 component:Transketola... 41 0.039
UniRef50_Q7N3C2 Cluster: Similar to 3-methyl-2-oxobutanoate dehy... 40 0.068
UniRef50_Q98FT3 Cluster: Acetoin dehydrogenase (TPP-dependent) a... 40 0.089
UniRef50_Q83X26 Cluster: Probable pyruvate dehydrogenase alpha-s... 40 0.12
UniRef50_Q1NYL5 Cluster: Pyruvate dehydrogenase E1 component alp... 39 0.16
UniRef50_Q748I3 Cluster: Dehydrogenase, E1 component, alpha and ... 38 0.36
UniRef50_Q97YF6 Cluster: Pyruvate dehydrogenase, alpha subunit (... 38 0.36
UniRef50_Q3WCG3 Cluster: Pyruvate dehydrogenase; n=4; Actinomyce... 37 0.63
UniRef50_Q49108 Cluster: Pyruvate dehydrogenase EI alpha subunit... 36 1.1
UniRef50_Q1AZ54 Cluster: Pyruvate dehydrogenase; n=1; Rubrobacte... 36 1.5
UniRef50_Q8YDW3 Cluster: 2-OXOISOVALERATE DEHYDROGENASE BETA SUB... 36 1.9
UniRef50_A6UDY5 Cluster: Dehydrogenase E1 component; n=2; Alphap... 36 1.9
UniRef50_Q9K3H0 Cluster: Putative pyruvate dehydrogenase alpha s... 35 2.5
UniRef50_Q83DQ6 Cluster: Dehydrogenase, E1 component, alpha subu... 35 2.5
UniRef50_Q02C52 Cluster: Pyruvate dehydrogenase; n=1; Solibacter... 35 2.5
UniRef50_Q4SR72 Cluster: Chromosome 11 SCAF14528, whole genome s... 34 4.4
UniRef50_A1SN84 Cluster: Pyruvate dehydrogenase; n=12; Bacteria|... 34 5.9
UniRef50_Q319T4 Cluster: Pyruvate dehydrogenase; n=1; Prochloroc... 33 7.8
UniRef50_Q0RVK8 Cluster: Probable pyruvate dehydrogenase; n=1; R... 33 7.8
UniRef50_Q0RLC2 Cluster: Pyruvate dehydrogenase E1 component, al... 33 7.8
UniRef50_Q0MX87 Cluster: Acetoin dehydrogenase alpha-subunit; n=... 33 7.8
UniRef50_A3SJ75 Cluster: 2-oxoisovalerate dehydrogenase beta sub... 33 7.8
>UniRef50_P26267 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha type I, mitochondrial precursor; n=10;
cellular organisms|Rep: Pyruvate dehydrogenase E1
component subunit alpha type I, mitochondrial precursor
- Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Length = 396
Score = 143 bits (346), Expect = 6e-33
Identities = 72/145 (49%), Positives = 86/145 (59%)
Frame = +1
Query: 343 ATFEIXPYKLHKWDXVPATSATLXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHL 522
ATF+ P+KLHK D P + + EDA+ Y Q+ +RR+E+A+GNLYKEK +RGFCHL
Sbjct: 30 ATFQTKPFKLHKLDSGPDINVHVTKEDAVHYYTQMLTIRRMESAAGNLYKEKKVRGFCHL 89
Query: 523 YSGQXXXXXXXXXXXXXXXSVITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPC 702
YSGQ + +TAYRCHGWTYL G SV VL ELTGR TG GK G
Sbjct: 90 YSGQEACAVGTKAAMDAGDAAVTAYRCHGWTYLSGSSVAKVLCELTGRITGNVYGKGGSM 149
Query: 703 ICTDATSMVATGIVGAQVPLGXXLA 777
GIVGAQ PLG +A
Sbjct: 150 HMYGENFYGGNGIVGAQQPLGTGIA 174
Score = 81.4 bits (192), Expect = 3e-14
Identities = 35/69 (50%), Positives = 43/69 (62%)
Frame = +3
Query: 684 GQGRSMHLYGRNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFFEA 863
G+G SMH+YG NFYGGNG P+G I FA YR + ++GDG N GQ FE+
Sbjct: 144 GKGGSMHMYGENFYGGNGIVGAQQPLGTGIAFAMKYRKEKNVCITMFGDGATNQGQLFES 203
Query: 864 YNMSKLWGL 890
NM+KLW L
Sbjct: 204 MNMAKLWDL 212
>UniRef50_UPI0000E4A5CB Cluster: PREDICTED: hypothetical protein,
partial; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: hypothetical protein, partial -
Strongylocentrotus purpuratus
Length = 378
Score = 139 bits (336), Expect = 1e-31
Identities = 67/139 (48%), Positives = 86/139 (61%)
Frame = +1
Query: 361 PYKLHKWDXVPATSATLXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXX 540
P+KLHK + P ++ L ++AL Y ++ +RR+ETA+ LYK K +RGFCHLYSGQ
Sbjct: 165 PFKLHKLEEGPKKTSVLTKDEALDYYHKMQTIRRMETAAATLYKSKEVRGFCHLYSGQEA 224
Query: 541 XXXXXXXXXXXXXSVITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDAT 720
+VITAYR HGW YL GV++ VL+ELTGRRTGC++GK G
Sbjct: 225 CAVGISSVLTPDDAVITAYRAHGWAYLRGVTLHGVLAELTGRRTGCAKGKGGSMHMYCKN 284
Query: 721 SMVATGIVGAQVPLGXXLA 777
GIVGAQVPLG +A
Sbjct: 285 FYGGNGIVGAQVPLGAGIA 303
Score = 78.2 bits (184), Expect = 3e-13
Identities = 36/69 (52%), Positives = 43/69 (62%)
Frame = +3
Query: 684 GQGRSMHLYGRNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFFEA 863
G+G SMH+Y +NFYGGNG P+G I A Y +LYGDG AN GQ FEA
Sbjct: 273 GKGGSMHMYCKNFYGGNGIVGAQVPLGAGIALALKYTDKKNVCISLYGDGAANQGQVFEA 332
Query: 864 YNMSKLWGL 890
YN++KLW L
Sbjct: 333 YNIAKLWDL 341
>UniRef50_Q9W4H4 Cluster: CG7024-PA; n=2; Sophophora|Rep: CG7024-PA
- Drosophila melanogaster (Fruit fly)
Length = 479
Score = 137 bits (331), Expect = 4e-31
Identities = 68/134 (50%), Positives = 80/134 (59%)
Frame = +1
Query: 364 YKLHKWDXVPATSATLXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXX 543
+K + + P L EDAL +Y Q+ LRR ET +GN YKE+ IRGFCHLY+GQ
Sbjct: 43 FKCYDLENGPTMDVELSREDALTMYTQMLELRRFETVAGNYYKERKIRGFCHLYNGQEAV 102
Query: 544 XXXXXXXXXXXXSVITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDATS 723
SVITAYRCH WTYLMGVS+ +++EL G RTGCSRGK G
Sbjct: 103 AVGMKQRLRSCDSVITAYRCHAWTYLMGVSLYEIMAELFGVRTGCSRGKGGSMHMYSDKF 162
Query: 724 MVATGIVGAQVPLG 765
GIVGAQVPLG
Sbjct: 163 YGGNGIVGAQVPLG 176
Score = 85.4 bits (202), Expect = 2e-15
Identities = 38/69 (55%), Positives = 45/69 (65%)
Frame = +3
Query: 684 GQGRSMHLYGRNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFFEA 863
G+G SMH+Y FYGGNG P+G IG A YR D G + LYGDG AN GQ FE+
Sbjct: 150 GKGGSMHMYSDKFYGGNGIVGAQVPLGAGIGLAHSYRKDNGVSVVLYGDGAANQGQIFES 209
Query: 864 YNMSKLWGL 890
+NM+KLW L
Sbjct: 210 FNMAKLWCL 218
>UniRef50_P08559 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha, somatic form, mitochondrial precursor;
n=110; cellular organisms|Rep: Pyruvate dehydrogenase E1
component subunit alpha, somatic form, mitochondrial
precursor - Homo sapiens (Human)
Length = 390
Score = 126 bits (303), Expect = 1e-27
Identities = 64/145 (44%), Positives = 82/145 (56%)
Frame = +1
Query: 343 ATFEIXPYKLHKWDXVPATSATLXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHL 522
ATFEI LH+ + P + L ED LK Y + +RR+E + LYK+KIIRGFCHL
Sbjct: 34 ATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHL 93
Query: 523 YSGQXXXXXXXXXXXXXXXSVITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPC 702
GQ +ITAYR HG+T+ G+SV +L+ELTGR+ GC++GK G
Sbjct: 94 CDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSM 153
Query: 703 ICTDATSMVATGIVGAQVPLGXXLA 777
GIVGAQVPLG +A
Sbjct: 154 HMYAKNFYGGNGIVGAQVPLGAGIA 178
Score = 79.0 bits (186), Expect = 2e-13
Identities = 36/69 (52%), Positives = 41/69 (59%)
Frame = +3
Query: 684 GQGRSMHLYGRNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFFEA 863
G+G SMH+Y +NFYGGNG P+G I A Y LYGDG AN GQ FEA
Sbjct: 148 GKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEA 207
Query: 864 YNMSKLWGL 890
YNM+ LW L
Sbjct: 208 YNMAALWKL 216
>UniRef50_Q6NX32 Cluster: Pyruvate dehydrogenase (Lipoamide) alpha
1; n=3; Tetrapoda|Rep: Pyruvate dehydrogenase
(Lipoamide) alpha 1 - Xenopus tropicalis (Western clawed
frog) (Silurana tropicalis)
Length = 369
Score = 120 bits (289), Expect = 5e-26
Identities = 61/137 (44%), Positives = 77/137 (56%)
Frame = +1
Query: 343 ATFEIXPYKLHKWDXVPATSATLXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHL 522
ATF+I +H+ + P T A L E L+ Y + +RR+E S LYK+KIIRGFCHL
Sbjct: 44 ATFDIKKCDVHRLEEGPPTQAVLTREQGLQYYRTMQTIRRMELKSDQLYKQKIIRGFCHL 103
Query: 523 YSGQXXXXXXXXXXXXXXXSVITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPC 702
Y GQ +ITAYR HG++Y GVSV +L+ELTGRR GC++GK G
Sbjct: 104 YDGQEACCVGLEAAINPTDHLITAYRAHGYSYTRGVSVKEILAELTGRRGGCAKGKGGSM 163
Query: 703 ICTDATSMVATGIVGAQ 753
GIVGAQ
Sbjct: 164 HMYAKNFYGGNGIVGAQ 180
Score = 37.5 bits (83), Expect(2) = 0.002
Identities = 14/26 (53%), Positives = 18/26 (69%)
Frame = +3
Query: 684 GQGRSMHLYGRNFYGGNGNCWCAGPV 761
G+G SMH+Y +NFYGGNG G +
Sbjct: 158 GKGGSMHMYAKNFYGGNGIVGAQGQI 183
Score = 27.1 bits (57), Expect(2) = 0.002
Identities = 10/15 (66%), Positives = 11/15 (73%)
Frame = +3
Query: 846 GQFFEAYNMSKLWGL 890
GQ FE YNM+ LW L
Sbjct: 181 GQIFETYNMAALWKL 195
>UniRef50_P16387 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha, mitochondrial precursor; n=34;
Dikarya|Rep: Pyruvate dehydrogenase E1 component subunit
alpha, mitochondrial precursor - Saccharomyces
cerevisiae (Baker's yeast)
Length = 420
Score = 106 bits (254), Expect = 9e-22
Identities = 56/117 (47%), Positives = 68/117 (58%)
Frame = +1
Query: 427 LKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVITAYRCH 606
L++Y+ + I+RR+E A LYK K IRGFCHL GQ S+IT+YRCH
Sbjct: 82 LQMYKDMVIIRRMEMACDALYKAKKIRGFCHLSVGQEAIAVGIENAITKLDSIITSYRCH 141
Query: 607 GWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDATSMVATGIVGAQVPLGXXLA 777
G+T++ G SV VL+EL GRR G S GK G GIVGAQVPLG LA
Sbjct: 142 GFTFMRGASVKAVLAELMGRRAGVSYGKGGSMHLYAPGFYGGNGIVGAQVPLGAGLA 198
Score = 81.8 bits (193), Expect = 2e-14
Identities = 35/69 (50%), Positives = 45/69 (65%)
Frame = +3
Query: 684 GQGRSMHLYGRNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFFEA 863
G+G SMHLY FYGGNG P+G + FA Y+ + +F LYGDG +N GQ FE+
Sbjct: 168 GKGGSMHLYAPGFYGGNGIVGAQVPLGAGLAFAHQYKNEDACSFTLYGDGASNQGQVFES 227
Query: 864 YNMSKLWGL 890
+NM+KLW L
Sbjct: 228 FNMAKLWNL 236
>UniRef50_Q23KL2 Cluster: Pyruvate dehydrogenase E1 component; n=5;
Intramacronucleata|Rep: Pyruvate dehydrogenase E1
component - Tetrahymena thermophila SB210
Length = 429
Score = 101 bits (243), Expect = 2e-20
Identities = 54/129 (41%), Positives = 72/129 (55%), Gaps = 2/129 (1%)
Frame = +1
Query: 397 TSATLXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXX 576
T +T E+ LKLY+ + ++R+IE A LYK++ IRGFCHLY GQ
Sbjct: 87 TQSTATKEELLKLYKDMNVMRKIELACDKLYKQREIRGFCHLYDGQEAVISGIEAACNLE 146
Query: 577 XSVITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPC-ICTDATSMV-ATGIVGA 750
++ITAYRCH Y G + +++EL GR+TG + GK G T GIVGA
Sbjct: 147 DAIITAYRCHCHAYTRGDTPHQIIAELMGRKTGSTGGKGGSMHFYRKKTHFYGGHGIVGA 206
Query: 751 QVPLGXXLA 777
QVP+G LA
Sbjct: 207 QVPMGAGLA 215
Score = 63.3 bits (147), Expect = 8e-09
Identities = 31/71 (43%), Positives = 40/71 (56%), Gaps = 2/71 (2%)
Frame = +3
Query: 684 GQGRSMHLYGR--NFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFF 857
G+G SMH Y + +FYGG+G P+G + FA Y + +YGDG AN GQ
Sbjct: 183 GKGGSMHFYRKKTHFYGGHGIVGAQVPMGAGLAFALKYEKKPNVSITMYGDGAANQGQIA 242
Query: 858 EAYNMSKLWGL 890
EA NM+ LW L
Sbjct: 243 EAANMAGLWNL 253
>UniRef50_Q8H1Y0 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha-2, mitochondrial precursor; n=33; cellular
organisms|Rep: Pyruvate dehydrogenase E1 component
subunit alpha-2, mitochondrial precursor - Arabidopsis
thaliana (Mouse-ear cress)
Length = 393
Score = 99.5 bits (237), Expect = 1e-19
Identities = 56/141 (39%), Positives = 75/141 (53%), Gaps = 2/141 (1%)
Frame = +1
Query: 361 PYKLHKWDXVPATSATLXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXX 540
P+ H + P+ S SE+ L + + +RR+E A+ +LYK K+IRGFCHLY GQ
Sbjct: 43 PFTSHLCES-PSRSVETSSEEILAFFRDMARMRRMEIAADSLYKAKLIRGFCHLYDGQEA 101
Query: 541 XXXXXXXXXXXXXSVITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPC--ICTD 714
++IT+YR H G ++ SEL GR+TGCS GK G D
Sbjct: 102 LAVGMEAAITKKDAIITSYRDHCTFIGRGGKLVDAFSELMGRKTGCSHGKGGSMHFYKKD 161
Query: 715 ATSMVATGIVGAQVPLGXXLA 777
A+ GIVGAQ+PLG LA
Sbjct: 162 ASFYGGHGIVGAQIPLGCGLA 182
Score = 76.2 bits (179), Expect = 1e-12
Identities = 37/71 (52%), Positives = 44/71 (61%), Gaps = 2/71 (2%)
Frame = +3
Query: 684 GQGRSMHLYGRN--FYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFF 857
G+G SMH Y ++ FYGG+G P+G + FA Y D TFALYGDG AN GQ F
Sbjct: 150 GKGGSMHFYKKDASFYGGHGIVGAQIPLGCGLAFAQKYNKDEAVTFALYGDGAANQGQLF 209
Query: 858 EAYNMSKLWGL 890
EA N+S LW L
Sbjct: 210 EALNISALWDL 220
>UniRef50_A2QWB4 Cluster: Catalytic activity: Pyruvate + Lipoamide
<=> S-Acetyldihydrolipoamide + CO2; n=3; Ascomycota|Rep:
Catalytic activity: Pyruvate + Lipoamide <=>
S-Acetyldihydrolipoamide + CO2 - Aspergillus niger
Length = 403
Score = 97.1 bits (231), Expect = 6e-19
Identities = 53/138 (38%), Positives = 73/138 (52%)
Frame = +1
Query: 364 YKLHKWDXVPATSATLXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXX 543
++ + D P + T S+ +LY ++++RR+E A+ LYKE+ IRGFCHL +GQ
Sbjct: 54 FETYNLDPPPYSLETTKSQ-LKQLYYDMSLIRRMELAADKLYKEQKIRGFCHLSTGQEAV 112
Query: 544 XXXXXXXXXXXXSVITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDATS 723
VITAYR HG+T + G SV ++ EL GRR G GK G
Sbjct: 113 AVGVEHGISPEDKVITAYRAHGFTLMRGGSVKSIIGELLGRRDGICHGKGGSVHMFTKNF 172
Query: 724 MVATGIVGAQVPLGXXLA 777
GIVG+ VPLG +A
Sbjct: 173 FGGNGIVGSNVPLGTGIA 190
Score = 75.8 bits (178), Expect = 1e-12
Identities = 36/75 (48%), Positives = 46/75 (61%)
Frame = +3
Query: 666 QDRLLPGQGRSMHLYGRNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANX 845
+D + G+G S+H++ +NF+GGNG P+G I FA Y T LYGDG AN
Sbjct: 154 RDGICHGKGGSVHMFTKNFFGGNGIVGSNVPLGTGIAFAQQYDDTKKVTVNLYGDGAANQ 213
Query: 846 GQFFEAYNMSKLWGL 890
GQ EAYNM+KLW L
Sbjct: 214 GQVHEAYNMAKLWEL 228
>UniRef50_Q9R9N5 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha; n=62; Bacteria|Rep: Pyruvate
dehydrogenase E1 component subunit alpha - Rhizobium
meliloti (Sinorhizobium meliloti)
Length = 348
Score = 93.9 bits (223), Expect = 5e-18
Identities = 56/136 (41%), Positives = 66/136 (48%), Gaps = 2/136 (1%)
Frame = +1
Query: 376 KWDXVPATSATLXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXX 555
K D T A ED LK Y ++ ++RR E +G LY I GFCHLY GQ
Sbjct: 20 KKDFAGGTIAEFSKEDDLKAYREMLLIRRFEEKAGQLYGMGFIGGFCHLYIGQEAVVVGM 79
Query: 556 XXXXXXXXSVITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGP--CICTDATSMV 729
VIT YR HG G+S V++ELTGRR G S+GK G +
Sbjct: 80 QLALKEGDQVITGYRDHGHMLACGMSARGVMAELTGRRGGLSKGKGGSMHMFSKEKHFYG 139
Query: 730 ATGIVGAQVPLGXXLA 777
GIVGAQV LG LA
Sbjct: 140 GHGIVGAQVSLGTGLA 155
Score = 65.3 bits (152), Expect = 2e-09
Identities = 30/74 (40%), Positives = 45/74 (60%), Gaps = 2/74 (2%)
Frame = +3
Query: 675 LLPGQGRSMHLYGR--NFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXG 848
L G+G SMH++ + +FYGG+G +G + FA YR + + A +GDG AN G
Sbjct: 120 LSKGKGGSMHMFSKEKHFYGGHGIVGAQVSLGTGLAFANRYRGNDNVSLAYFGDGAANQG 179
Query: 849 QFFEAYNMSKLWGL 890
Q +E++NM+ LW L
Sbjct: 180 QVYESFNMAALWKL 193
>UniRef50_Q4T3C0 Cluster: Chromosome undetermined SCAF10102, whole
genome shotgun sequence; n=1; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF10102,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 491
Score = 91.1 bits (216), Expect = 4e-17
Identities = 44/102 (43%), Positives = 57/102 (55%)
Frame = +1
Query: 370 LHKWDXVPATSATLXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXX 549
LH+ + P A L E L+ Y + +RR+E + LYK+KIIRGFCHLY GQ
Sbjct: 5 LHRLEEGPPEKAELTREQGLQYYRTMQTIRRMELKADQLYKQKIIRGFCHLYDGQEACAA 64
Query: 550 XXXXXXXXXXSVITAYRCHGWTYLMGVSVLXVLSELTGRRTG 675
+ITAYR HG+T+ GVSV +L+ELTG G
Sbjct: 65 GIEAAITPSDHLITAYRAHGYTFTRGVSVKEILAELTGETGG 106
>UniRef50_Q1EGI2 Cluster: Pyruvate dehydrogenase E1 alpha subunit;
n=6; Spirotrichea|Rep: Pyruvate dehydrogenase E1 alpha
subunit - Euplotes sp. BB-2004
Length = 389
Score = 90.6 bits (215), Expect = 5e-17
Identities = 51/145 (35%), Positives = 72/145 (49%), Gaps = 3/145 (2%)
Frame = +1
Query: 352 EIXPYKLHKWDXVPA-TSATLXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYS 528
E+ +K+H+ + T AT + L Y+ + ++RR+E S LYK K IRGFCHLY
Sbjct: 30 ELPKFKVHRIEESELPTKATTTKSELLNYYKDMALMRRVEIVSDMLYKNKWIRGFCHLYD 89
Query: 529 GQXXXXXXXXXXXXXXXSVITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPC-- 702
GQ +I AYR H G + +++E+ R TG S+GK G
Sbjct: 90 GQESITVGMEAALTMEDHIINAYRDHTTAMGRGHTSYEIIAEMMQRSTGSSKGKGGSMHY 149
Query: 703 ICTDATSMVATGIVGAQVPLGXXLA 777
C+ GIVGAQVP+G +A
Sbjct: 150 YCSKNNFYGGNGIVGAQVPVGTGVA 174
Score = 67.7 bits (158), Expect = 4e-10
Identities = 34/73 (46%), Positives = 40/73 (54%), Gaps = 2/73 (2%)
Frame = +3
Query: 684 GQGRSMHLY--GRNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFF 857
G+G SMH Y NFYGGNG PVG + F Y A+YGDG AN GQ +
Sbjct: 142 GKGGSMHYYCSKNNFYGGNGIVGAQVPVGTGVAFGIKYEGKKEVCVAMYGDGAANQGQIY 201
Query: 858 EAYNMSKLWGLAL 896
EA NM+ LW L +
Sbjct: 202 EAANMAGLWKLPI 214
>UniRef50_O96865 Cluster: Pyruvate dehydrogenase E1 alpha subunit;
n=2; Trypanosoma cruzi|Rep: Pyruvate dehydrogenase E1
alpha subunit - Trypanosoma cruzi
Length = 378
Score = 90.2 bits (214), Expect = 6e-17
Identities = 55/144 (38%), Positives = 72/144 (50%), Gaps = 6/144 (4%)
Frame = +1
Query: 361 PYKLHKW--DXVPA--TSATLXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYS 528
P+KLH D VP T+AT +E K E + +RR+E+ YK K IRGFCHLY
Sbjct: 22 PFKLHTAGRDDVPPVPTTATYDTEQMKKCLEMMFRIRRMESLCDQSYKLKKIRGFCHLYI 81
Query: 529 GQXXXXXXXXXXXXXXXSVITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCIC 708
GQ ++TAYR H W + G + V +E+ G+ GCS+GK G
Sbjct: 82 GQEAIPVGMENVLTLEDLIVTAYRDHAWYIVRGGTPGEVFAEMFGKEGGCSKGKGGSMHM 141
Query: 709 TDATS--MVATGIVGAQVPLGXXL 774
+ GIVGAQVP+G L
Sbjct: 142 YSVKNNFFGGNGIVGAQVPIGAGL 165
Score = 52.0 bits (119), Expect = 2e-05
Identities = 30/71 (42%), Positives = 38/71 (53%), Gaps = 5/71 (7%)
Frame = +3
Query: 684 GQGRSMHLYG--RNFYGGNGNCWCAGPVGXRIG--FAPXYR-ADGGXTFALYGDGXANXG 848
G+G SMH+Y NF+GGNG P+G +G FA R YGDG AN G
Sbjct: 134 GKGGSMHMYSVKNNFFGGNGIVGAQVPIGAGLGWRFALENRDKPRNVAVTFYGDGAANQG 193
Query: 849 QFFEAYNMSKL 881
Q FEA N++ +
Sbjct: 194 QVFEAMNIAAI 204
>UniRef50_Q4WHM5 Cluster: Pyruvate dehydrogenase E1 component alpha
subunit, putative; n=1; Aspergillus fumigatus|Rep:
Pyruvate dehydrogenase E1 component alpha subunit,
putative - Aspergillus fumigatus (Sartorya fumigata)
Length = 360
Score = 88.6 bits (210), Expect = 2e-16
Identities = 45/107 (42%), Positives = 61/107 (57%)
Frame = +1
Query: 457 RRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVITAYRCHGWTYLMGVSV 636
+R+E A+ LYK+K IRGFCHL +GQ +ITAYR HG+T++ G S+
Sbjct: 81 QRLEIAADALYKQKKIRGFCHLSTGQEAVAVGIEYGISKEDKLITAYRSHGFTFMRGGSI 140
Query: 637 LXVLSELTGRRTGCSRGKEGPCICTDATSMVATGIVGAQVPLGXXLA 777
+ ++ EL GR+ G S GK G A GIVGA VP+G +A
Sbjct: 141 MSIVGELLGRQDGISHGKGGSMHMFCAGFFGGNGIVGAHVPVGAGIA 187
Score = 74.9 bits (176), Expect = 3e-12
Identities = 36/75 (48%), Positives = 43/75 (57%)
Frame = +3
Query: 666 QDRLLPGQGRSMHLYGRNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANX 845
QD + G+G SMH++ F+GGNG PVG I FA Y T YGDG AN
Sbjct: 151 QDGISHGKGGSMHMFCAGFFGGNGIVGAHVPVGAGIAFAQQYNDRDNITVDAYGDGAANQ 210
Query: 846 GQFFEAYNMSKLWGL 890
GQ EA+NM+KLW L
Sbjct: 211 GQVHEAFNMAKLWNL 225
>UniRef50_O66112 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha; n=38; Proteobacteria|Rep: Pyruvate
dehydrogenase E1 component subunit alpha - Zymomonas
mobilis
Length = 354
Score = 86.6 bits (205), Expect = 8e-16
Identities = 51/123 (41%), Positives = 63/123 (51%), Gaps = 3/123 (2%)
Frame = +1
Query: 418 EDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQ-XXXXXXXXXXXXXXXSVITA 594
E+ L+ Y ++ ++RR E G LY +I GFCHLY GQ SVIT
Sbjct: 37 EELLEFYRRMLMIRRFEERCGQLYGLGLIAGFCHLYIGQEAVAVGLQAALQPGRDSVITG 96
Query: 595 YRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGP--CICTDATSMVATGIVGAQVPLGX 768
YR HG G+ V++ELTGR +G S GK G T+ GIVGAQVPLG
Sbjct: 97 YREHGHMLAYGIDPKIVMAELTGRASGISHGKGGSMHMFSTEHKFFGGNGIVGAQVPLGA 156
Query: 769 XLA 777
LA
Sbjct: 157 GLA 159
Score = 75.8 bits (178), Expect = 1e-12
Identities = 35/71 (49%), Positives = 45/71 (63%), Gaps = 2/71 (2%)
Frame = +3
Query: 684 GQGRSMHLYG--RNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFF 857
G+G SMH++ F+GGNG P+G + FA YR DGG + A +GDG AN GQ +
Sbjct: 127 GKGGSMHMFSTEHKFFGGNGIVGAQVPLGAGLAFAHKYRNDGGCSAAYFGDGSANQGQVY 186
Query: 858 EAYNMSKLWGL 890
EAYNM+ LW L
Sbjct: 187 EAYNMAALWKL 197
>UniRef50_Q8SQM8 Cluster: PYRUVATE DEHYDROGENASE E1 COMPONENT ALPHA
SUBUNIT; n=1; Encephalitozoon cuniculi|Rep: PYRUVATE
DEHYDROGENASE E1 COMPONENT ALPHA SUBUNIT -
Encephalitozoon cuniculi
Length = 349
Score = 85.4 bits (202), Expect = 2e-15
Identities = 44/120 (36%), Positives = 66/120 (55%)
Frame = +1
Query: 418 EDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVITAY 597
+ A+ +Y+Q+ +R ++ A YK K IRGFCHL GQ +V ++Y
Sbjct: 37 DKAVYIYKQMMRMRCMDEAMDREYKRKNIRGFCHLSIGQEGIYAALEYAMDGDVAV-SSY 95
Query: 598 RCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDATSMVATGIVGAQVPLGXXLA 777
RCHG Y+ G S+L ++ E+ GR+ G +GK G + + GIVGAQ+PLG +A
Sbjct: 96 RCHGIAYVTGCSILEIMGEVLGRQAGVCKGKGGSMHLYNKSFFGGHGIVGAQIPLGLGMA 155
Score = 64.1 bits (149), Expect = 5e-09
Identities = 31/77 (40%), Positives = 47/77 (61%), Gaps = 6/77 (7%)
Frame = +3
Query: 684 GQGRSMHLYGRNFYGGNGNCWCAGPVGXRIGFAPXYR-----ADGGXT-FALYGDGXANX 845
G+G SMHLY ++F+GG+G P+G + +A Y + GG +A YGDG AN
Sbjct: 125 GKGGSMHLYNKSFFGGHGIVGAQIPLGLGMAYALEYNRRMGWSQGGKVCYAFYGDGAANQ 184
Query: 846 GQFFEAYNMSKLWGLAL 896
GQ +E++NM+ +W L +
Sbjct: 185 GQVWESFNMAMVWRLPI 201
>UniRef50_Q4QDQ1 Cluster: Pyruvate dehydrogenase E1 component alpha
subunit, putative; n=5; Euglenozoa|Rep: Pyruvate
dehydrogenase E1 component alpha subunit, putative -
Leishmania major
Length = 378
Score = 83.8 bits (198), Expect = 6e-15
Identities = 54/145 (37%), Positives = 68/145 (46%), Gaps = 6/145 (4%)
Frame = +1
Query: 361 PYKLH---KWDXVPATSATLXSEDALKLYEQLTI-LRRIETASGNLYKEKIIRGFCHLYS 528
P+KLH + D P + + + LK L +RR+E+ YK K IRGFCHLY
Sbjct: 22 PFKLHTAGRTDMAPLPTQAVYDAEQLKQSLALMFRIRRMESLCDQSYKLKKIRGFCHLYI 81
Query: 529 GQXXXXXXXXXXXXXXXSVITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGP--C 702
GQ +IT YR HGW G V +E+ GR+ GCS+GK G
Sbjct: 82 GQEAIPAGMENVLTFEDPIITGYRDHGWYISRGGKPEDVFAEMFGRQGGCSKGKGGSMHM 141
Query: 703 ICTDATSMVATGIVGAQVPLGXXLA 777
D GIVGAQV +G LA
Sbjct: 142 YRVDNGFYGGNGIVGAQVSIGAGLA 166
>UniRef50_A7CXZ4 Cluster: Pyruvate dehydrogenase; n=1; Opitutaceae
bacterium TAV2|Rep: Pyruvate dehydrogenase - Opitutaceae
bacterium TAV2
Length = 365
Score = 81.8 bits (193), Expect = 2e-14
Identities = 55/168 (32%), Positives = 72/168 (42%), Gaps = 2/168 (1%)
Frame = +1
Query: 400 SATLXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXX 579
+A L ++LY + +RR E S Y+ K I GF HLY GQ
Sbjct: 28 NADLTPAARIELYRTMVRIRRFEERSLRAYQAKKIGGFLHLYIGQEAVAVGCCSLMGEHD 87
Query: 580 SVITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDATSMV--ATGIVGAQ 753
VITAYR HG +G+ +++EL G+ TGCS+GK G D + GIVG Q
Sbjct: 88 HVITAYRDHGHAIAVGMDTKALMAELYGKATGCSKGKGGSMHYFDPSKNYWGGHGIVGGQ 147
Query: 754 VPLGXXLASPPXTAPTXXSRSLFMETXPPTRVNSSKPTTCLNYGDLPC 897
+PLG LA S FM + + DLPC
Sbjct: 148 IPLGTGLAYAVKYRGLKGSAMAFMGDGAVNQGAVHEAYNLAALWDLPC 195
Score = 57.6 bits (133), Expect = 4e-07
Identities = 28/71 (39%), Positives = 39/71 (54%), Gaps = 2/71 (2%)
Frame = +3
Query: 684 GQGRSMHLY--GRNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFF 857
G+G SMH + +N++GG+G P+G + +A YR G A GDG N G
Sbjct: 123 GKGGSMHYFDPSKNYWGGHGIVGGQIPLGTGLAYAVKYRGLKGSAMAFMGDGAVNQGAVH 182
Query: 858 EAYNMSKLWGL 890
EAYN++ LW L
Sbjct: 183 EAYNLAALWDL 193
>UniRef50_A6DTS3 Cluster: Dehydrogenase complex, E1 component, alpha
subunit; n=1; Lentisphaera araneosa HTCC2155|Rep:
Dehydrogenase complex, E1 component, alpha subunit -
Lentisphaera araneosa HTCC2155
Length = 320
Score = 79.4 bits (187), Expect = 1e-13
Identities = 42/125 (33%), Positives = 62/125 (49%), Gaps = 2/125 (1%)
Frame = +1
Query: 409 LXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVI 588
+ E AL++ EQ+ +RR E Y++K I GFCH Y GQ + +
Sbjct: 4 IGKEKALQMLEQMIRVRRFEEGCLKSYQQKFITGFCHTYIGQEAVAVGAMAHLTPTDAYV 63
Query: 589 TAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGP--CICTDATSMVATGIVGAQVPL 762
T+YRCH + G++ V++E+ G+ TGC RGK G + GIVG Q+P+
Sbjct: 64 TSYRCHAQGLIGGLTSREVMAEMFGKITGCVRGKGGSMHVFSKKNNYLGGHGIVGGQIPI 123
Query: 763 GXXLA 777
G A
Sbjct: 124 GLGAA 128
Score = 51.2 bits (117), Expect = 4e-05
Identities = 24/69 (34%), Positives = 36/69 (52%), Gaps = 2/69 (2%)
Frame = +3
Query: 684 GQGRSMHLYGR--NFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFF 857
G+G SMH++ + N+ GG+G P+G FA Y G +GDG + G F
Sbjct: 96 GKGGSMHVFSKKNNYLGGHGIVGGQIPIGLGAAFALKYEEKEGVALTFFGDGASMQGTFH 155
Query: 858 EAYNMSKLW 884
E+ N++ LW
Sbjct: 156 ESLNLASLW 164
>UniRef50_Q2S150 Cluster: Pyruvate dehydrogenase E1 component, alpha
subunit; n=1; Salinibacter ruber DSM 13855|Rep: Pyruvate
dehydrogenase E1 component, alpha subunit - Salinibacter
ruber (strain DSM 13855)
Length = 470
Score = 79.0 bits (186), Expect = 2e-13
Identities = 50/145 (34%), Positives = 68/145 (46%), Gaps = 3/145 (2%)
Frame = +1
Query: 352 EIXPYKLHKWDXVPATSATLXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSG 531
E Y+ + D + ++ L L + + RR E +Y+ + I GF HLY G
Sbjct: 126 ETVTYETYPADTYGHDELGIADDEVLDLLRNMLLQRRFENRCRQMYQRQKISGFLHLYIG 185
Query: 532 QXXXXXXXXXXXXXXX-SVITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCIC 708
Q SVITAYR HG MG++ ++EL G+ TGCS+GK G
Sbjct: 186 QEAVSTGSVNAIELGDDSVITAYRDHGMGLAMGITPEAGMAELFGKETGCSKGKGGSMHF 245
Query: 709 TDATSMVATG--IVGAQVPLGXXLA 777
DA + G IVGA +PLG LA
Sbjct: 246 FDAEKKMMGGHAIVGAHLPLGAGLA 270
Score = 43.6 bits (98), Expect = 0.007
Identities = 22/73 (30%), Positives = 36/73 (49%), Gaps = 2/73 (2%)
Frame = +3
Query: 684 GQGRSMHLYG--RNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFF 857
G+G SMH + + GG+ P+G + FA YR + +GDG + G F
Sbjct: 238 GKGGSMHFFDAEKKMMGGHAIVGAHLPLGAGLAFAHKYRGEDNVCLCFFGDGAMHQGAFR 297
Query: 858 EAYNMSKLWGLAL 896
EA N++ ++ L +
Sbjct: 298 EACNLAGIYELPI 310
>UniRef50_Q5FNM5 Cluster: Pyruvate dehydrogenase E1 component alpha
subunit; n=4; Bacteria|Rep: Pyruvate dehydrogenase E1
component alpha subunit - Gluconobacter oxydans
(Gluconobacter suboxydans)
Length = 334
Score = 77.8 bits (183), Expect = 4e-13
Identities = 47/125 (37%), Positives = 60/125 (48%), Gaps = 2/125 (1%)
Frame = +1
Query: 409 LXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVI 588
L E + Y + ++RR E +G LY +I GFCHLY GQ I
Sbjct: 16 LSPETMKRAYRDMLLVRRFEEKAGQLYGMGLIGGFCHLYIGQEAVVVGIGLNMKQGDKSI 75
Query: 589 TAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGP--CICTDATSMVATGIVGAQVPL 762
T+YR HG + G++ V++ELTGR G S GK G + GIVGAQV L
Sbjct: 76 TSYRDHGQMLVAGMTPRGVMAELTGRSGGYSHGKGGSMHMFSREKEFYGGHGIVGAQVAL 135
Query: 763 GXXLA 777
G LA
Sbjct: 136 GTGLA 140
Score = 50.0 bits (114), Expect = 8e-05
Identities = 23/68 (33%), Positives = 38/68 (55%), Gaps = 2/68 (2%)
Frame = +3
Query: 684 GQGRSMHLYGRN--FYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFF 857
G+G SMH++ R FYGG+G +G + FA YR + +G+G + GQ +
Sbjct: 108 GKGGSMHMFSREKEFYGGHGIVGAQVALGTGLAFANKYRGTDEVSIVYFGEGASAQGQVY 167
Query: 858 EAYNMSKL 881
E++N++ L
Sbjct: 168 ESFNLAAL 175
>UniRef50_Q95VS6 Cluster: Pyruvate dehydrogenase E1 alpha subunit;
n=2; Antonospora locustae|Rep: Pyruvate dehydrogenase E1
alpha subunit - Antonospora locustae (Nosema locustae)
Length = 342
Score = 72.1 bits (169), Expect = 2e-11
Identities = 41/126 (32%), Positives = 59/126 (46%)
Frame = +1
Query: 400 SATLXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXX 579
S + +D KLY ++ +R ++ + +Y +IRGFCHL GQ
Sbjct: 21 SCKIRYDDVEKLYRKMLCMRYMDESISKMYSRGLIRGFCHLDIGQ-EEVYAALCHVARND 79
Query: 580 SVITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDATSMVATGIVGAQVP 759
I +YRCH + V ++ EL GR G ++GK G + GIVGAQVP
Sbjct: 80 KFIGSYRCHALAVAAEIPVREIVGELLGRAGGVAKGKGGSMHLYNDLLFGGHGIVGAQVP 139
Query: 760 LGXXLA 777
LG +A
Sbjct: 140 LGCGMA 145
Score = 54.0 bits (124), Expect = 5e-06
Identities = 27/80 (33%), Positives = 40/80 (50%), Gaps = 9/80 (11%)
Frame = +3
Query: 684 GQGRSMHLYGRNFYGGNGNCWCAGPVGXRIGFAPXYR---------ADGGXTFALYGDGX 836
G+G SMHLY +GG+G P+G + +A Y F YGDG
Sbjct: 115 GKGGSMHLYNDLLFGGHGIVGAQVPLGCGMAYALKYNEGLEDVRDTTSKAVVFCFYGDGA 174
Query: 837 ANXGQFFEAYNMSKLWGLAL 896
+N GQ E++N++K+W L +
Sbjct: 175 SNQGQIHESFNVAKIWNLPI 194
>UniRef50_Q1ATM5 Cluster: Pyruvate dehydrogenase; n=1; Rubrobacter
xylanophilus DSM 9941|Rep: Pyruvate dehydrogenase -
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Length = 353
Score = 71.7 bits (168), Expect = 2e-11
Identities = 44/129 (34%), Positives = 62/129 (48%), Gaps = 3/129 (2%)
Frame = +1
Query: 400 SATLXSEDAL-KLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXX 576
SA S D L +LY ++ ++R E A +++ I G+ H+Y+GQ
Sbjct: 19 SAVATSPDRLAELYGKMVLIRAFEDACQRAFRQGKIGGYLHVYTGQEAVATGFLEAFREG 78
Query: 577 XSVITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDATS--MVATGIVGA 750
VIT YR H L+G V++EL G+RTG +GK G D M GIVG
Sbjct: 79 DRVITGYRDHAHALLLGCDPKEVMAELFGKRTGLVKGKGGSMHLFDVERGFMGGYGIVGG 138
Query: 751 QVPLGXXLA 777
+PLG +A
Sbjct: 139 HIPLGVGIA 147
Score = 52.8 bits (121), Expect = 1e-05
Identities = 30/73 (41%), Positives = 37/73 (50%), Gaps = 2/73 (2%)
Frame = +3
Query: 675 LLPGQGRSMHLYG--RNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXG 848
L+ G+G SMHL+ R F GG G P+G I +A Y G GDG N G
Sbjct: 112 LVKGKGGSMHLFDVERGFMGGYGIVGGHIPLGVGIAYALRYGGSEGICQLYLGDGAINNG 171
Query: 849 QFFEAYNMSKLWG 887
F EA N++ LWG
Sbjct: 172 AFHEAANLAGLWG 184
>UniRef50_Q12FH4 Cluster: Pyruvate dehydrogenase; n=37;
Bacteria|Rep: Pyruvate dehydrogenase - Polaromonas sp.
(strain JS666 / ATCC BAA-500)
Length = 337
Score = 71.7 bits (168), Expect = 2e-11
Identities = 41/120 (34%), Positives = 60/120 (50%), Gaps = 2/120 (1%)
Frame = +1
Query: 424 ALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVITAYRC 603
AL + + +RR+E LY E+ IRGF HLY G+ +V+ YR
Sbjct: 21 ALAVLAGMLRIRRMEEKCAQLYGEQKIRGFLHLYIGEEAVAVGALRALQPQDNVVATYRE 80
Query: 604 HGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDATSMVATG--IVGAQVPLGXXLA 777
HG L G+++ +++E+ G+R GCSRG+ G D + G IVG +PL LA
Sbjct: 81 HGHALLRGLAMNGIMAEMYGKREGCSRGRGGSMHLFDRATRFYGGNAIVGGGLPLAAGLA 140
Score = 45.6 bits (103), Expect = 0.002
Identities = 25/71 (35%), Positives = 33/71 (46%), Gaps = 2/71 (2%)
Frame = +3
Query: 684 GQGRSMHLYGR--NFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFF 857
G+G SMHL+ R FYGGN P+ + A T +G+G G F
Sbjct: 108 GRGGSMHLFDRATRFYGGNAIVGGGLPLAAGLALADKMAGRQALTACFFGEGAIAEGAFH 167
Query: 858 EAYNMSKLWGL 890
EA N++ LW L
Sbjct: 168 EAANLAALWQL 178
>UniRef50_Q1EGH8 Cluster: Pyruvate dehydrogenase E1 alpha subunit;
n=1; Nyctotherus ovalis|Rep: Pyruvate dehydrogenase E1
alpha subunit - Nyctotherus ovalis
Length = 136
Score = 70.5 bits (165), Expect = 6e-11
Identities = 33/96 (34%), Positives = 48/96 (50%)
Frame = +1
Query: 397 TSATLXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXX 576
T A ++ LK Y + RR+E +YK+K +RGFCHL GQ
Sbjct: 41 TKAQTNRDEMLKYYHDMNFQRRVEIMCDEIYKKKEVRGFCHLMDGQEAVSVGVEAGITKE 100
Query: 577 XSVITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSR 684
+ITAYRCHG G + +++E+ G+ TG S+
Sbjct: 101 DHLITAYRCHGVLLGRGETAARLIAEMMGKATGASK 136
>UniRef50_Q9Z8N4 Cluster: Pyruvate Dehydrogenase Alpha; n=8;
Chlamydiaceae|Rep: Pyruvate Dehydrogenase Alpha -
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Length = 342
Score = 69.3 bits (162), Expect = 1e-10
Identities = 34/117 (29%), Positives = 53/117 (45%)
Frame = +1
Query: 427 LKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVITAYRCH 606
+K +Q+ ++R E Y E ++ GF H Y+GQ V ++YRCH
Sbjct: 32 IKFLKQMVLIREFEARGEEAYLEGLVGGFYHSYAGQEAVATAAIANTGLDPWVFSSYRCH 91
Query: 607 GWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDATSMVATGIVGAQVPLGXXLA 777
L+ + + + +EL G+ TGC+ G+ G GIVG Q+PL A
Sbjct: 92 ALAILLNIPLQEIAAELLGKETGCALGRGGSMHMCGPNFPGGFGIVGGQIPLAAGAA 148
>UniRef50_Q74AD3 Cluster: Dehydrogenase complex, E1 component, alpha
subunit; n=5; Geobacter|Rep: Dehydrogenase complex, E1
component, alpha subunit - Geobacter sulfurreducens
Length = 325
Score = 68.5 bits (160), Expect = 2e-10
Identities = 41/127 (32%), Positives = 58/127 (45%), Gaps = 2/127 (1%)
Frame = +1
Query: 403 ATLXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXS 582
A L + LK++EQ+ + R E + Y + I GF HLYSGQ
Sbjct: 7 AILPDSELLKMHEQMVLSREFEESCAEQYTKGHITGFLHLYSGQEAVAVGATAALRKDDY 66
Query: 583 VITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDATSMVATG--IVGAQV 756
+++AYR H + G V++EL G+ TG +GK G D + G IVG Q
Sbjct: 67 ILSAYREHAQAIVRGAEPRRVMAELFGKATGMCKGKGGSMHLFDPSLAFMGGYAIVGGQF 126
Query: 757 PLGXXLA 777
P+ LA
Sbjct: 127 PIAVGLA 133
Score = 52.0 bits (119), Expect = 2e-05
Identities = 26/71 (36%), Positives = 37/71 (52%), Gaps = 2/71 (2%)
Frame = +3
Query: 684 GQGRSMHLYGRN--FYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFF 857
G+G SMHL+ + F GG P+ + FA YR +G + +GDG N G F
Sbjct: 101 GKGGSMHLFDPSLAFMGGYAIVGGQFPIAVGLAFASKYRKEGRISACFFGDGAVNQGTFH 160
Query: 858 EAYNMSKLWGL 890
E+ N ++LW L
Sbjct: 161 ESLNWARLWEL 171
>UniRef50_A5UU15 Cluster: Pyruvate dehydrogenase; n=3; Chloroflexi
(class)|Rep: Pyruvate dehydrogenase - Roseiflexus sp.
RS-1
Length = 350
Score = 66.1 bits (154), Expect = 1e-09
Identities = 38/125 (30%), Positives = 57/125 (45%), Gaps = 2/125 (1%)
Frame = +1
Query: 409 LXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVI 588
L + + Y Q+ ++RR E +Y I GF HLY G+ +
Sbjct: 21 LDAATLIDYYRQMVLIRRFEEKCQEMYTRAKIGGFLHLYIGEEATAVGAIAALRPDDHIF 80
Query: 589 TAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDATSMVATG--IVGAQVPL 762
T YR HG G+ + +++EL G+ TGCS+G G DA+ G IVG+ +PL
Sbjct: 81 THYRDHGHAIARGLDINALMAELFGKVTGCSKGLGGSMHFADASKNFWGGYAIVGSHLPL 140
Query: 763 GXXLA 777
+A
Sbjct: 141 ATGVA 145
Score = 42.7 bits (96), Expect = 0.013
Identities = 21/71 (29%), Positives = 32/71 (45%), Gaps = 2/71 (2%)
Frame = +3
Query: 684 GQGRSMHLY--GRNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFF 857
G G SMH +NF+GG P+ + + +GDG N G+F+
Sbjct: 113 GLGGSMHFADASKNFWGGYAIVGSHLPLATGVALGMKMQRKDSVVMVFFGDGATNGGEFY 172
Query: 858 EAYNMSKLWGL 890
E+ N ++LW L
Sbjct: 173 ESLNFAQLWKL 183
>UniRef50_A0LSF3 Cluster: Pyruvate dehydrogenase; n=5; Bacteria|Rep:
Pyruvate dehydrogenase - Acidothermus cellulolyticus
(strain ATCC 43068 / 11B)
Length = 375
Score = 64.9 bits (151), Expect = 3e-09
Identities = 39/126 (30%), Positives = 57/126 (45%), Gaps = 3/126 (2%)
Frame = +1
Query: 391 PATSATLXSEDALKLY-EQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXX 567
PA D L+ Y + ++RR E + +Y+ I G+CHL G+
Sbjct: 29 PADRLAQEPPDKLRAYYRMMQLIRRFEERAAEMYQRAKIGGYCHLNLGEEATVVGLMDAM 88
Query: 568 XXXXSVITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDATSMV--ATGI 741
+ T YR HG+ G+ V++EL GR TG S+G G DA + + GI
Sbjct: 89 APHDYLFTTYREHGYALARGIDPGRVMAELFGRTTGVSKGWGGSMHLFDAETRLLGGYGI 148
Query: 742 VGAQVP 759
VG Q+P
Sbjct: 149 VGGQIP 154
>UniRef50_Q2ITF8 Cluster: Acetoin dehydrogenase (TPP-dependent)
alpha chain; n=1; Rhodopseudomonas palustris HaA2|Rep:
Acetoin dehydrogenase (TPP-dependent) alpha chain -
Rhodopseudomonas palustris (strain HaA2)
Length = 323
Score = 59.7 bits (138), Expect = 1e-07
Identities = 44/148 (29%), Positives = 65/148 (43%), Gaps = 3/148 (2%)
Frame = +1
Query: 415 SEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVITA 594
SE +L + +R +E Y E+ +R HL GQ ++
Sbjct: 2 SELPRRLLFDMMRIRAVEETIAKRYGEQKMRCPTHLSVGQEAVAAAAGAALEPADLAVSG 61
Query: 595 YRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDATS--MVATGIVGAQVPLGX 768
+R H G S+ +++E+ GR TGCSRGK G D ++ M +T IVG VP+G
Sbjct: 62 HRAHAHYLAKGGSLKAMIAEIYGRVTGCSRGKGGSMHLIDESAGFMGSTAIVGGTVPVGV 121
Query: 769 XLASPPXTAPTXXSRSLFM-ETXPPTRV 849
LA P T +F+ + P T V
Sbjct: 122 GLAYPMKLKRTGQIACVFLGDAVPETGV 149
Score = 33.5 bits (73), Expect = 7.8
Identities = 21/68 (30%), Positives = 27/68 (39%), Gaps = 2/68 (2%)
Frame = +3
Query: 684 GQGRSMHLYGRN--FYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFF 857
G+G SMHL + F G PVG + + + G GD G FF
Sbjct: 92 GKGGSMHLIDESAGFMGSTAIVGGTVPVGVGLAYPMKLKRTGQIACVFLGDAVPETGVFF 151
Query: 858 EAYNMSKL 881
EA N + L
Sbjct: 152 EAVNFAVL 159
>UniRef50_Q1KSF1 Cluster: Apicoplast pyruvate dehydrogenase E1 alpha
subunit; n=1; Toxoplasma gondii|Rep: Apicoplast pyruvate
dehydrogenase E1 alpha subunit - Toxoplasma gondii
Length = 635
Score = 59.3 bits (137), Expect = 1e-07
Identities = 37/117 (31%), Positives = 54/117 (46%), Gaps = 2/117 (1%)
Frame = +1
Query: 433 LYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVITAYRCHGW 612
L E + R +E A LY GF HLY+GQ +V++ YR H
Sbjct: 261 LLEDMLTGRMVEDACARLYYMGKTAGFVHLYTGQEAVSAGVIKLLRPDDAVVSTYRDHVH 320
Query: 613 TYLMGVSVLXVLSELTGRRTGCSRGKEGPC-ICTDATSMV-ATGIVGAQVPLGXXLA 777
GV V V++EL G+ TGCSRG+ G + + +M+ +G Q+P+ A
Sbjct: 321 ATSKGVPVREVMAELFGKATGCSRGRGGSMHMFSKKHNMIGGFAFIGEQIPVALGYA 377
>UniRef50_Q6MAE2 Cluster: Putative pyruvate dehydrogenase
(Lipoamide), E1 component, alpha chain; n=1; Candidatus
Protochlamydia amoebophila UWE25|Rep: Putative pyruvate
dehydrogenase (Lipoamide), E1 component, alpha chain -
Protochlamydia amoebophila (strain UWE25)
Length = 342
Score = 58.8 bits (136), Expect = 2e-07
Identities = 34/123 (27%), Positives = 56/123 (45%)
Frame = +1
Query: 409 LXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVI 588
L + ++ ++Q+ +R E + + Y++ I GF H Y GQ
Sbjct: 21 LGPQALIECFQQMLKIRNFELRAESAYQQGKIGGFFHAYVGQEAIQTAAVQAIGQSNWYA 80
Query: 589 TAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDATSMVATGIVGAQVPLGX 768
T+YRCH L+G + +++EL GR TG ++G+ G + GIV QVP+
Sbjct: 81 TSYRCHALALLLGATPNELMAELYGRATGNAKGRGGSMHFFTDRLLGGFGIVTGQVPIAT 140
Query: 769 XLA 777
A
Sbjct: 141 GAA 143
Score = 41.9 bits (94), Expect = 0.022
Identities = 22/70 (31%), Positives = 31/70 (44%), Gaps = 1/70 (1%)
Frame = +3
Query: 684 GQGRSMHLYGRNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALY-GDGXANXGQFFE 860
G+G SMH + GG G P+ FA Y+ + + GDG G F E
Sbjct: 113 GRGGSMHFFTDRLLGGFGIVTGQVPIATGAAFALKYKGNKNEVAVCFMGDGAVPQGSFHE 172
Query: 861 AYNMSKLWGL 890
+ N++ LW L
Sbjct: 173 SLNLASLWNL 182
>UniRef50_Q1XDM0 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha; n=52; cellular organisms|Rep: Pyruvate
dehydrogenase E1 component subunit alpha - Porphyra
yezoensis
Length = 346
Score = 58.0 bits (134), Expect = 3e-07
Identities = 32/101 (31%), Positives = 46/101 (45%)
Frame = +1
Query: 394 ATSATLXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXX 573
+T L + L LYE + + R E +Y + + GF HLY+GQ
Sbjct: 16 STGLNLNKSNLLVLYEDMLLGRNFEDMCAQMYYKGKMFGFVHLYNGQEAVSTGVIKLLNP 75
Query: 574 XXSVITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEG 696
V + YR H GV V++EL G+ TGCS+G+ G
Sbjct: 76 TDYVCSTYRDHVHALSKGVPSKNVMAELFGKETGCSKGRGG 116
Score = 46.4 bits (105), Expect = 0.001
Identities = 30/80 (37%), Positives = 36/80 (45%), Gaps = 9/80 (11%)
Frame = +3
Query: 684 GQGRSMHLYG--RNFYGGNGNCWCAGPVGXRIGFAPXYRA-------DGGXTFALYGDGX 836
G+G SMH++ NF GG PV F YR D T +GDG
Sbjct: 113 GRGGSMHIFSAPHNFLGGFAFIAEGIPVATGAAFQSIYRQQVLKETEDLRVTACFFGDGT 172
Query: 837 ANXGQFFEAYNMSKLWGLAL 896
N GQFFE NM+ LW L +
Sbjct: 173 TNNGQFFECLNMAVLWKLPI 192
>UniRef50_Q3J9C5 Cluster: Dehydrogenase, E1 component; n=3;
Proteobacteria|Rep: Dehydrogenase, E1 component -
Nitrosococcus oceani (strain ATCC 19707 / NCIMB 11848)
Length = 339
Score = 57.2 bits (132), Expect = 6e-07
Identities = 41/126 (32%), Positives = 52/126 (41%), Gaps = 7/126 (5%)
Frame = +1
Query: 421 DALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSV----- 585
D +L ++ RR E S Y E+ + GF HLYSGQ V
Sbjct: 5 DRKRLLREMVFFRRFEDRSFEAYMERKVGGFLHLYSGQEAVATGVLEMVQADRGVGFDYA 64
Query: 586 ITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDATSMVATG--IVGAQVP 759
IT YR H G V++EL G+ TG SRG+ G D + G +VG P
Sbjct: 65 ITGYRDHIHAIKAGAPAREVMAELYGKETGSSRGRGGSMHIFDPSVRFMGGYALVGQPFP 124
Query: 760 LGXXLA 777
L LA
Sbjct: 125 LAAGLA 130
Score = 42.3 bits (95), Expect = 0.017
Identities = 23/71 (32%), Positives = 33/71 (46%), Gaps = 2/71 (2%)
Frame = +3
Query: 684 GQGRSMHLYGRN--FYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFF 857
G+G SMH++ + F GG P+ + A ++ +G GDG N G F
Sbjct: 98 GRGGSMHIFDPSVRFMGGYALVGQPFPLAAGLALACKHQKEGRIAVCFLGDGANNQGTFH 157
Query: 858 EAYNMSKLWGL 890
E NM+ LW L
Sbjct: 158 ETMNMASLWKL 168
>UniRef50_A6GG24 Cluster: Pyruvate dehydrogenase (Lipoamide), alpha
subunit; n=1; Plesiocystis pacifica SIR-1|Rep: Pyruvate
dehydrogenase (Lipoamide), alpha subunit - Plesiocystis
pacifica SIR-1
Length = 339
Score = 56.4 bits (130), Expect = 1e-06
Identities = 35/127 (27%), Positives = 53/127 (41%), Gaps = 2/127 (1%)
Frame = +1
Query: 388 VPATSATLXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXX 567
+P T + ++ LK + ++ +RR E + Y I GF HLY GQ
Sbjct: 10 LPETLTSAGKDETLKAFREMLRIRRFEETAARAYTRGKISGFLHLYIGQEAIAVGVKLAM 69
Query: 568 XXXXSVITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDATSMVATG--I 741
V+ YR HG+ G ++EL G+ TG G G D + + G I
Sbjct: 70 QANDRVVGTYRDHGYALAQGSDANACMAELFGKATGLVGGVGGSMHYFDRPNGLWGGYAI 129
Query: 742 VGAQVPL 762
+G VP+
Sbjct: 130 IGNHVPV 136
Score = 38.7 bits (86), Expect = 0.21
Identities = 24/74 (32%), Positives = 29/74 (39%), Gaps = 2/74 (2%)
Frame = +3
Query: 675 LLPGQGRSMHLYGR--NFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXG 848
L+ G G SMH + R +GG PV FA Y D T GDG G
Sbjct: 106 LVGGVGGSMHYFDRPNGLWGGYAIIGNHVPVAAGHAFASKYLGDDAVTMCFLGDGAVGIG 165
Query: 849 QFFEAYNMSKLWGL 890
E ++ LW L
Sbjct: 166 PTHEGMTLAGLWDL 179
>UniRef50_A7BPK6 Cluster: Pyruvate dehydrogenase; n=1; Beggiatoa sp.
PS|Rep: Pyruvate dehydrogenase - Beggiatoa sp. PS
Length = 331
Score = 56.0 bits (129), Expect = 1e-06
Identities = 34/117 (29%), Positives = 54/117 (46%), Gaps = 2/117 (1%)
Frame = +1
Query: 418 EDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVITAY 597
E+ L Y L ++RR+E A Y E+ +R HL GQ + +++
Sbjct: 14 EELLTFYRSLLLIRRVEEAIAERYTEQEMRCPTHLCIGQEAVAVGVCKMLQQSDGIFSSH 73
Query: 598 RCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTD--ATSMVATGIVGAQVPL 762
R H G + +++EL G+ TGC G+ G D A + AT IVG+ +P+
Sbjct: 74 RAHSHYLAKGGDLKAMIAELYGKSTGCCGGRGGSMHLIDLAAGFIGATPIVGSTIPI 130
>UniRef50_Q28MR4 Cluster: Dehydrogenase E1 component; n=8;
Bacteria|Rep: Dehydrogenase E1 component - Jannaschia
sp. (strain CCS1)
Length = 675
Score = 54.4 bits (125), Expect = 4e-06
Identities = 38/130 (29%), Positives = 55/130 (42%), Gaps = 2/130 (1%)
Frame = +1
Query: 394 ATSATLXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXX 573
AT L +D + + +RR ET + L+ + +I+G H GQ
Sbjct: 13 ATPNGLAPKDLRAALKMMLRIRRFETRAKELFLQGVIKGTAHSSVGQEAIAAGACAVLEP 72
Query: 574 XXSVITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDATSMV--ATGIVG 747
++T +R HG T G + + +EL GR TG G G D + A GIVG
Sbjct: 73 ADFILTHHRGHGHTIAKGADLGRMFAELMGRETGYCAGLGGSMHIADFDRGILGANGIVG 132
Query: 748 AQVPLGXXLA 777
A + LG A
Sbjct: 133 AGIGLGTGAA 142
Score = 46.8 bits (106), Expect = 8e-04
Identities = 26/73 (35%), Positives = 34/73 (46%), Gaps = 2/73 (2%)
Frame = +3
Query: 684 GQGRSMHL--YGRNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFF 857
G G SMH+ + R G NG +G A A G + +GDG AN G F
Sbjct: 110 GLGGSMHIADFDRGILGANGIVGAGIGLGTGAALAEQLDATGAIGISFFGDGAANEGIFH 169
Query: 858 EAYNMSKLWGLAL 896
EA N++ +W L L
Sbjct: 170 EAMNLAAIWKLPL 182
>UniRef50_Q13GQ3 Cluster: Putative 2-oxo acid dehydrogenase alpha
subunit; n=1; Burkholderia xenovorans LB400|Rep:
Putative 2-oxo acid dehydrogenase alpha subunit -
Burkholderia xenovorans (strain LB400)
Length = 334
Score = 54.4 bits (125), Expect = 4e-06
Identities = 31/114 (27%), Positives = 50/114 (43%), Gaps = 2/114 (1%)
Frame = +1
Query: 427 LKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVITAYRCH 606
+ +Y + ++R +E + L+ + + GF HL GQ ++ T +R H
Sbjct: 20 IDIYRTMVLVREVELSLSRLFADSEVPGFIHLSLGQEAVSAGVASVLEVQDTLATTHRGH 79
Query: 607 GWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDATSMV--ATGIVGAQVPL 762
G G+ V E+ GR G +G+ G D V A GIVGA +P+
Sbjct: 80 GHVLARGIDVGGFFKEIMGRVGGLCKGRGGSMHVADLALGVLGANGIVGAGIPI 133
Score = 37.5 bits (83), Expect = 0.48
Identities = 23/72 (31%), Positives = 28/72 (38%), Gaps = 2/72 (2%)
Frame = +3
Query: 675 LLPGQGRSMHL--YGRNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXG 848
L G+G SMH+ G NG P+ A R G A +GDG G
Sbjct: 103 LCKGRGGSMHVADLALGVLGANGIVGAGIPIALGSAVAHHVRKTRGVAVAFFGDGAMAEG 162
Query: 849 QFFEAYNMSKLW 884
E NM+ LW
Sbjct: 163 VLHETMNMAALW 174
>UniRef50_Q5VGY4 Cluster: Pyruvate dehydrogenase alpha subunit; n=6;
Plasmodium|Rep: Pyruvate dehydrogenase alpha subunit -
Plasmodium falciparum
Length = 608
Score = 54.4 bits (125), Expect = 4e-06
Identities = 37/130 (28%), Positives = 55/130 (42%), Gaps = 3/130 (2%)
Frame = +1
Query: 397 TSATLXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXX 576
+ + E+ LYE + + R E LY K + GF HLY+GQ
Sbjct: 184 SDVNISREEICTLYEDMYLGRLFENLVAKLYYNKRVNGFVHLYNGQEAVSTGIIKNLKNS 243
Query: 577 XSVITAYRCHGWTYLMGVSVLXVLSELTGRRTG-CSRGKEGPC-ICTDATSMV-ATGIVG 747
V + YR H GV +L+EL G G ++GK G I + + + G +G
Sbjct: 244 DFVTSTYRDHVHALSKGVPAHKILNELYGNYYGSTNKGKGGSMHIYSKENNFIGGFGFIG 303
Query: 748 AQVPLGXXLA 777
Q+P+ LA
Sbjct: 304 EQIPIAVGLA 313
>UniRef50_Q1ARM0 Cluster: Pyruvate dehydrogenase; n=3; Bacteria|Rep:
Pyruvate dehydrogenase - Rubrobacter xylanophilus
(strain DSM 9941 / NBRC 16129)
Length = 332
Score = 54.0 bits (124), Expect = 5e-06
Identities = 33/120 (27%), Positives = 50/120 (41%), Gaps = 2/120 (1%)
Frame = +1
Query: 409 LXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVI 588
L E + + + +RR E L+K + GF HLY G+ +
Sbjct: 2 LGEEKLVGMLRLMLRIRRFEEKLAELFKRGKLPGFVHLYIGEEAVAVGACSALREDDRIT 61
Query: 589 TAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDAT--SMVATGIVGAQVPL 762
+ +R HG G V +++EL G+ G RGK G D + M GIVG +P+
Sbjct: 62 STHRGHGHVIAKGADVSRMMAELLGKEAGYCRGKGGSMHTVDFSLGIMGTNGIVGGGIPI 121
Score = 38.7 bits (86), Expect = 0.21
Identities = 21/71 (29%), Positives = 31/71 (43%), Gaps = 2/71 (2%)
Frame = +3
Query: 684 GQGRSMHL--YGRNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFF 857
G+G SMH + G NG P+ + T + +GDG +N G FF
Sbjct: 94 GKGGSMHTVDFSLGIMGTNGIVGGGIPIAVGSAWGDRQLGRDTVTVSFFGDGASNQGVFF 153
Query: 858 EAYNMSKLWGL 890
E N++ +W L
Sbjct: 154 EGMNLAAIWKL 164
>UniRef50_A0HHH5 Cluster: Dehydrogenase, E1 component; n=2;
Bacteria|Rep: Dehydrogenase, E1 component - Comamonas
testosteroni KF-1
Length = 327
Score = 54.0 bits (124), Expect = 5e-06
Identities = 39/123 (31%), Positives = 52/123 (42%), Gaps = 4/123 (3%)
Frame = +1
Query: 424 ALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVITAYRC 603
A +L EQ+ +R +E +L K I+G HL GQ V + YR
Sbjct: 16 AKELLEQMIRIRLLEEKIADLRKSGEIQGSVHLCIGQEAIYSGSCAARQPGDRVFSTYRG 75
Query: 604 HGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCI--CTDATSMVATGIVGAQVPL--GXX 771
HGW + GV +L+EL R TG G+ G + IVGA P+ G
Sbjct: 76 HGWAHACGVPAEAILAELLARETGVCAGRGGSAYFSAPEWGFFGENSIVGAGAPIACGAA 135
Query: 772 LAS 780
LAS
Sbjct: 136 LAS 138
Score = 34.7 bits (76), Expect = 3.4
Identities = 16/52 (30%), Positives = 20/52 (38%)
Frame = +3
Query: 720 FYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFFEAYNMS 875
F+G N P+ A DG +GDG N G FEA N +
Sbjct: 117 FFGENSIVGAGAPIACGAALASTMAKDGSLAITAFGDGAMNQGGVFEAMNFA 168
>UniRef50_Q7V0M7 Cluster: Dehydrogenase, E1 component; n=1;
Prochlorococcus marinus subsp. pastoris str.
CCMP1986|Rep: Dehydrogenase, E1 component -
Prochlorococcus marinus subsp. pastoris (strain CCMP
1378 / MED4)
Length = 324
Score = 53.2 bits (122), Expect = 9e-06
Identities = 33/110 (30%), Positives = 51/110 (46%), Gaps = 2/110 (1%)
Frame = +1
Query: 454 LRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVITAYRCHGWTYLMGVS 633
+R IE A +L K+ +RG H Y G+ +V + +R HG G +
Sbjct: 41 IRAIEEAIVSLAKDNKLRGPIHSYVGEEAIATGVLSHAKPIDAVTSTHRGHGHYIAKGGN 100
Query: 634 VLXVLSELTGRRTGCSRGKEGPCICTDAT--SMVATGIVGAQVPLGXXLA 777
+ ++ EL G+ +GC+ GK G D + A GIVG VP+ +A
Sbjct: 101 ISMLIDELHGKESGCNGGKGGSMHVADLSINHFGANGIVGGGVPIACGIA 150
Score = 38.3 bits (85), Expect = 0.27
Identities = 21/73 (28%), Positives = 32/73 (43%), Gaps = 2/73 (2%)
Frame = +3
Query: 684 GQGRSMHL--YGRNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFF 857
G+G SMH+ N +G NG P+ I A F +GDG +N G
Sbjct: 118 GKGGSMHVADLSINHFGANGIVGGGVPIACGIALANKLDKKDSIVFCFFGDGASNQGVVL 177
Query: 858 EAYNMSKLWGLAL 896
E++N++ L +
Sbjct: 178 ESFNLAGFLSLPI 190
>UniRef50_A3VIE7 Cluster: Tpp-dependent acetoin dehydrogenase e1
alpha-subunit; n=2; Rhodobacterales|Rep: Tpp-dependent
acetoin dehydrogenase e1 alpha-subunit - Rhodobacterales
bacterium HTCC2654
Length = 335
Score = 53.2 bits (122), Expect = 9e-06
Identities = 35/130 (26%), Positives = 54/130 (41%), Gaps = 2/130 (1%)
Frame = +1
Query: 373 HKWDXVPATSATLXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXX 552
H + A S T +ED L++Y Q+ +R E + LY + G H+YSG+
Sbjct: 5 HLREDTMAKSKT-NTEDYLRMYRQMVRIRTFEDNANQLYLSAKMPGLTHMYSGEEAVAVG 63
Query: 553 XXXXXXXXXSVITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDAT--SM 726
+ + +R HG G + EL G+ G RGK G D + ++
Sbjct: 64 ICEALTDDDRITSTHRGHGHCVAKGAEFKEMFCELLGKEEGYCRGKGGSMHIADQSHGNL 123
Query: 727 VATGIVGAQV 756
A IVG +
Sbjct: 124 GANAIVGGSM 133
Score = 39.1 bits (87), Expect = 0.16
Identities = 22/71 (30%), Positives = 31/71 (43%), Gaps = 2/71 (2%)
Frame = +3
Query: 684 GQGRSMHLYGRNFYGGNGNCWCAGPVGXRIGFAPXYRADGGX--TFALYGDGXANXGQFF 857
G+G SMH+ ++ N G +G G A + G T +GDG G +
Sbjct: 108 GKGGSMHIADQSHGNLGANAIVGGSMGIATGSALRAKLQGSDDVTVCFFGDGATAQGLMY 167
Query: 858 EAYNMSKLWGL 890
E NM+ LW L
Sbjct: 168 EVMNMAALWKL 178
>UniRef50_A6Q3I6 Cluster: Pyruvate/2-oxoglutarate dehydrogenase
complex, E1 component, alpha subunit; n=2; unclassified
Epsilonproteobacteria|Rep: Pyruvate/2-oxoglutarate
dehydrogenase complex, E1 component, alpha subunit -
Nitratiruptor sp. (strain SB155-2)
Length = 323
Score = 52.8 bits (121), Expect = 1e-05
Identities = 25/73 (34%), Positives = 39/73 (53%), Gaps = 2/73 (2%)
Frame = +3
Query: 684 GQGRSMHLYGR--NFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFF 857
G+G SMHL+ +FYGG+ P+ +A + FA++GDG +N G FF
Sbjct: 92 GKGGSMHLFDPRLSFYGGDAIVAGHLPIATGCAYARKIEGENAGVFAIFGDGASNAGAFF 151
Query: 858 EAYNMSKLWGLAL 896
E+ N++ W L +
Sbjct: 152 ESINIASAWKLPI 164
>UniRef50_A5V557 Cluster: Pyruvate dehydrogenase; n=1; Sphingomonas
wittichii RW1|Rep: Pyruvate dehydrogenase - Sphingomonas
wittichii RW1
Length = 331
Score = 51.6 bits (118), Expect = 3e-05
Identities = 31/123 (25%), Positives = 58/123 (47%), Gaps = 2/123 (1%)
Frame = +1
Query: 415 SEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVITA 594
++ +L+ Y ++ +R+ E + ++ + I G H Y+GQ ++
Sbjct: 6 NDRSLEKYRRMQRIRQFEDLAEAIHAQGEIPGSLHTYAGQEASGVGACMALDDTDYMVGT 65
Query: 595 YRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDAT--SMVATGIVGAQVPLGX 768
+R HG G + +++EL G+ TG +GK G +D + S+ T IVG+ VP+
Sbjct: 66 HRSHGHPIAKGAKLRPLMAELLGKATGICKGKGGSMHLSDFSVGSLGETSIVGSGVPVAA 125
Query: 769 XLA 777
A
Sbjct: 126 GAA 128
Score = 37.1 bits (82), Expect = 0.63
Identities = 22/72 (30%), Positives = 30/72 (41%), Gaps = 3/72 (4%)
Frame = +3
Query: 684 GQGRSMHLYGRNFYGGNGNCWCAG---PVGXRIGFAPXYRADGGXTFALYGDGXANXGQF 854
G+G SMHL + G G G PV + +G +GDG N G F
Sbjct: 96 GKGGSMHLSDFSV-GSLGETSIVGSGVPVAAGAALGSKLQGNGRVALCFFGDGATNEGAF 154
Query: 855 FEAYNMSKLWGL 890
E N++ +W L
Sbjct: 155 HEGMNLAAVWAL 166
>UniRef50_P27745 Cluster: Acetoin:2,6-dichlorophenolindophenol
oxidoreductase subunit alpha; n=58; cellular
organisms|Rep: Acetoin:2,6-dichlorophenolindophenol
oxidoreductase subunit alpha - Ralstonia eutropha
(strain ATCC 17699 / H16 / DSM 428 / Stanier
337)(Cupriavidus necator (strain ATCC 17699 / H16 / DSM
428 / Stanier337))
Length = 333
Score = 51.2 bits (117), Expect = 4e-05
Identities = 33/120 (27%), Positives = 51/120 (42%), Gaps = 2/120 (1%)
Frame = +1
Query: 409 LXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVI 588
L E L +Y ++ +R E + I GF HLY+G+ +
Sbjct: 14 LDKETLLTVYRKMRTIRDFEERLHVDFGRGDIPGFVHLYAGEEAAGVGILHHLNDGDRIA 73
Query: 589 TAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDATS--MVATGIVGAQVPL 762
+ +R HG GV + ++ E+ G++ G GK G D + M A GI+GA PL
Sbjct: 74 STHRGHGHCIAKGVDPVAMMKEIYGKKGGSCNGKGGSMHIADLSKGMMGANGILGAGAPL 133
Score = 44.4 bits (100), Expect = 0.004
Identities = 22/71 (30%), Positives = 32/71 (45%), Gaps = 2/71 (2%)
Frame = +3
Query: 684 GQGRSMHL--YGRNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFF 857
G+G SMH+ + G NG P+ A +R G GDG +N G F
Sbjct: 106 GKGGSMHIADLSKGMMGANGILGAGAPLICGAALAAKFRGKGEVGITFCGDGASNQGTFL 165
Query: 858 EAYNMSKLWGL 890
E+ N++ +W L
Sbjct: 166 ESLNLAAVWNL 176
>UniRef50_A5V540 Cluster: Dehydrogenase, E1 component; n=3;
Proteobacteria|Rep: Dehydrogenase, E1 component -
Sphingomonas wittichii RW1
Length = 334
Score = 50.0 bits (114), Expect = 8e-05
Identities = 33/123 (26%), Positives = 53/123 (43%), Gaps = 4/123 (3%)
Frame = +1
Query: 421 DALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVITAYR 600
+ ++LY ++ +R E + G L+ I GF HL GQ ++ + +R
Sbjct: 22 ELIELYRRMVTIREAEKSCGALFAAGEIPGFIHLSDGQEGVSVGVMASLRADDTIASTHR 81
Query: 601 CHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDAT--SMVATGIV--GAQVPLGX 768
HG G+ + EL G+ G +G+ G D + + A GIV G + LG
Sbjct: 82 GHGHALAKGLGLDGFFRELMGKADGACKGRGGSMHVADLSVGMLGANGIVGGGVAIALGS 141
Query: 769 XLA 777
LA
Sbjct: 142 GLA 144
>UniRef50_A4AFX0 Cluster: Acetoin dehydrogenase (TPP-dependent)
alpha chain; n=1; marine actinobacterium PHSC20C1|Rep:
Acetoin dehydrogenase (TPP-dependent) alpha chain -
marine actinobacterium PHSC20C1
Length = 327
Score = 49.6 bits (113), Expect = 1e-04
Identities = 37/135 (27%), Positives = 55/135 (40%), Gaps = 4/135 (2%)
Frame = +1
Query: 388 VPATSATLXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXX 567
V T A DAL+L + +R E L+ + ++RG HL GQ
Sbjct: 6 VNPTLADPLPADALELLRSMYEIRFFEDEIMGLFSQNLVRGSTHLCQGQEAVTVGVCSAL 65
Query: 568 XXXXSVITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDAT--SMVATGI 741
++ YR HG MG + E+ GR G GK G D + ++ + I
Sbjct: 66 SPGDTMTCTYRGHGAVLAMGAPLDRAFGEILGRAGGLCGGKGGSMHLADVSVGALGSNAI 125
Query: 742 VGAQVP--LGXXLAS 780
VG +P +G LA+
Sbjct: 126 VGGHLPTTVGAALAA 140
Score = 43.2 bits (97), Expect = 0.010
Identities = 24/74 (32%), Positives = 34/74 (45%), Gaps = 2/74 (2%)
Frame = +3
Query: 675 LLPGQGRSMHLYGRNFYGGNGNCWCAGPVGXRIG--FAPXYRADGGXTFALYGDGXANXG 848
L G+G SMHL + N G + +G A YR + A +GDG N G
Sbjct: 102 LCGGKGGSMHLADVSVGALGSNAIVGGHLPTTVGAALAASYRGTSEVSVAFFGDGSTNIG 161
Query: 849 QFFEAYNMSKLWGL 890
F E+ N++ +W L
Sbjct: 162 AFHESLNLASIWKL 175
>UniRef50_A4X7T3 Cluster: Dehydrogenase, E1 component; n=3;
Actinomycetales|Rep: Dehydrogenase, E1 component -
Salinispora tropica CNB-440
Length = 323
Score = 48.4 bits (110), Expect = 3e-04
Identities = 32/114 (28%), Positives = 49/114 (42%)
Frame = +1
Query: 424 ALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVITAYRC 603
+++LY + ++RR E + L + I G H Y GQ V +R
Sbjct: 6 SVRLYRTVRLIRRFEERAIELVRSGHIVGGIHPYVGQEGIAAGVCAALRPDDVVAGTHRG 65
Query: 604 HGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDATSMVATGIVGAQVPLG 765
HG G +++EL GR TG +RG+ G D A G++GA +G
Sbjct: 66 HGHVLAKGADPARMMAELCGRVTGLNRGRGGSMHAAD----FAVGVLGANAIVG 115
Score = 36.7 bits (81), Expect = 0.83
Identities = 21/69 (30%), Positives = 29/69 (42%), Gaps = 2/69 (2%)
Frame = +3
Query: 684 GQGRSMHL--YGRNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFF 857
G+G SMH + G N G + +A R D + GDG N G
Sbjct: 93 GRGGSMHAADFAVGVLGANAIVGAGGAIVTGAVWARRRRGDDLVGVSFLGDGAVNEGMLL 152
Query: 858 EAYNMSKLW 884
EA+N++ LW
Sbjct: 153 EAFNLAALW 161
>UniRef50_A3CMZ3 Cluster: Pyruvate dehydrogenase, TPP-dependent E1
component alpha-subunit, putative; n=22; Bacteria|Rep:
Pyruvate dehydrogenase, TPP-dependent E1 component
alpha-subunit, putative - Streptococcus sanguinis
(strain SK36)
Length = 357
Score = 47.2 bits (107), Expect = 6e-04
Identities = 30/128 (23%), Positives = 52/128 (40%), Gaps = 2/128 (1%)
Frame = +1
Query: 370 LHKWDXVPATSATLXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXX 549
L +D + E A +Y+ + +R E + + I GF HLY+G+
Sbjct: 26 LKVYDATEVEVEQVSKEKAKTMYKTMWDIRNFEENTRRFFAAGQIPGFVHLYAGEEAIAT 85
Query: 550 XXXXXXXXXXSVITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDATSMV 729
+ + +R HG G + +++E+ G+ TG +GK G D +
Sbjct: 86 GVCANLTDKDYITSTHRGHGHCVAKGGDLKGMMAEIFGKETGLGKGKGGSMHIADLDKGI 145
Query: 730 --ATGIVG 747
A G+VG
Sbjct: 146 LGANGMVG 153
Score = 39.5 bits (88), Expect = 0.12
Identities = 25/73 (34%), Positives = 31/73 (42%), Gaps = 4/73 (5%)
Frame = +3
Query: 684 GQGRSMHL--YGRNFYGGNGNCWCAGPVGXRIGFAPX--YRADGGXTFALYGDGXANXGQ 851
G+G SMH+ + G NG G G G A Y +GDG AN G
Sbjct: 131 GKGGSMHIADLDKGILGANG--MVGGGFGLATGAAMRNKYLKTDSVAVCFFGDGAANEGN 188
Query: 852 FFEAYNMSKLWGL 890
F E NM+ +W L
Sbjct: 189 FHECLNMASIWKL 201
>UniRef50_Q18CB6 Cluster: Acetoin:2,6-dichlorophenolindophenol
oxidoreductase alpha subunit; n=2; Clostridium
difficile|Rep: Acetoin:2,6-dichlorophenolindophenol
oxidoreductase alpha subunit - Clostridium difficile
(strain 630)
Length = 322
Score = 46.4 bits (105), Expect = 0.001
Identities = 32/132 (24%), Positives = 55/132 (41%)
Frame = +1
Query: 406 TLXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSV 585
++ E L++Y+++ R+ E + ++ G HL GQ V
Sbjct: 4 SISKETLLEMYKRMNQARKFEEKVSWFFARGMVHGTTHLSVGQEASSVAAVMALEKGDLV 63
Query: 586 ITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDATSMVATGIVGAQVPLG 765
+R H MG+ + +++EL G+ TG +GK G D + +G +GA +G
Sbjct: 64 SLTHRGHSQFIGMGIDLNKMMAELMGKETGFCKGKGGSMHIAD----IESGNLGANGVVG 119
Query: 766 XXLASPPXTAPT 801
L P A T
Sbjct: 120 GGLTIAPGAALT 131
Score = 40.7 bits (91), Expect = 0.051
Identities = 25/77 (32%), Positives = 35/77 (45%), Gaps = 6/77 (7%)
Frame = +3
Query: 684 GQGRSMHLYGRNFYGGNGNCWCAGPVGXRIGFAPX------YRADGGXTFALYGDGXANX 845
G+G SMH+ +GN G VG + AP Y+ G +GDG +N
Sbjct: 97 GKGGSMHIADIE----SGNLGANGVVGGGLTIAPGAALTQQYKKTGKIVLCSFGDGASNE 152
Query: 846 GQFFEAYNMSKLWGLAL 896
G F E N+S +W L +
Sbjct: 153 GTFHEGINLSSIWKLPI 169
>UniRef50_Q2WB98 Cluster: Pyruvate/2-oxoglutarate dehydrogenase
complex; n=1; Magnetospirillum magneticum AMB-1|Rep:
Pyruvate/2-oxoglutarate dehydrogenase complex -
Magnetospirillum magneticum (strain AMB-1 / ATCC 700264)
Length = 647
Score = 45.6 bits (103), Expect = 0.002
Identities = 25/71 (35%), Positives = 32/71 (45%)
Frame = +3
Query: 684 GQGRSMHLYGRNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFFEA 863
G+G S HL G+ F+ NG PV + A DGG GDG G FEA
Sbjct: 96 GRGGSQHLRGQGFFS-NGIIGGMAPVAAGLAMAHRLAGDGGVAVLFIGDGGLGQGALFEA 154
Query: 864 YNMSKLWGLAL 896
N++ + L L
Sbjct: 155 LNLAASFSLPL 165
Score = 39.1 bits (87), Expect = 0.16
Identities = 27/110 (24%), Positives = 45/110 (40%)
Frame = +1
Query: 448 TILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVITAYRCHGWTYLMG 627
T++R +E +LY E + G H GQ +++ +R HG
Sbjct: 17 TLIRVVEERLLSLYGEGRLHGTVHTCIGQEWTGVSVASALRSGDYILSNHRGHGHYLAWT 76
Query: 628 VSVLXVLSELTGRRTGCSRGKEGPCICTDATSMVATGIVGAQVPLGXXLA 777
V +++E+ GR +G RG+ G + GI+G P+ LA
Sbjct: 77 DDVEGLIAEVMGRESGVCRGRGGSQHLR-GQGFFSNGIIGGMAPVAAGLA 125
>UniRef50_Q3DZ88 Cluster: Dehydrogenase, E1 component; n=1;
Chloroflexus aurantiacus J-10-fl|Rep: Dehydrogenase, E1
component - Chloroflexus aurantiacus J-10-fl
Length = 334
Score = 45.6 bits (103), Expect = 0.002
Identities = 27/109 (24%), Positives = 47/109 (43%), Gaps = 2/109 (1%)
Frame = +1
Query: 442 QLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVITAYRCHGWTYL 621
++ I+R E + L+ ++ G HL GQ ++ +R HG
Sbjct: 33 RMQIIRAFEEKAEELFARGLVHGTMHLSIGQEAVAIGASAAMKPGDYLLNHHRGHGHCLA 92
Query: 622 MGVSVLXVLSELTGRRTGCSRGKEGP--CICTDATSMVATGIVGAQVPL 762
G V +++E G+ TG RG+ G + ++ A GIVG +P+
Sbjct: 93 WGSDVRLMMAEFLGKETGYCRGRGGSMHIANVEMNNLGANGIVGGGIPI 141
Score = 45.6 bits (103), Expect = 0.002
Identities = 23/71 (32%), Positives = 33/71 (46%), Gaps = 2/71 (2%)
Frame = +3
Query: 684 GQGRSMHLYG--RNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFF 857
G+G SMH+ N G NG P+ +G + R ++GDG N G F
Sbjct: 114 GRGGSMHIANVEMNNLGANGIVGGGIPISVGVGLSIKKRRSSQVCLTIFGDGAVNTGAFH 173
Query: 858 EAYNMSKLWGL 890
E+ NM+ +W L
Sbjct: 174 ESLNMASIWNL 184
>UniRef50_A0UXT3 Cluster: Pyruvate dehydrogenase; n=1; Clostridium
cellulolyticum H10|Rep: Pyruvate dehydrogenase -
Clostridium cellulolyticum H10
Length = 321
Score = 45.2 bits (102), Expect = 0.002
Identities = 31/125 (24%), Positives = 52/125 (41%), Gaps = 2/125 (1%)
Frame = +1
Query: 409 LXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVI 588
+ +E ++LY + +R +E YK ++ HL GQ +
Sbjct: 1 MENERFIELYRVMQTIRIVERKIEEEYKNDEMKTPIHLSIGQEAIAAGVCINLRKDDYLF 60
Query: 589 TAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGP--CICTDATSMVATGIVGAQVPL 762
+R H G + +++EL R+TGC+ G+ G + D +T IVG +PL
Sbjct: 61 GTHRSHAQYIAKGGDIKQMIAELYLRKTGCTSGRGGSMHLMAADRGIFGSTAIVGGSLPL 120
Query: 763 GXXLA 777
G A
Sbjct: 121 GTGTA 125
Score = 36.7 bits (81), Expect = 0.83
Identities = 21/68 (30%), Positives = 31/68 (45%), Gaps = 2/68 (2%)
Frame = +3
Query: 684 GQGRSMHLYG--RNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFF 857
G+G SMHL R +G + P+G A + + T +GDG A+ G F
Sbjct: 93 GRGGSMHLMAADRGIFGSTAIVGGSLPLGTGTALASKIQKNDRVTAVFFGDGAADEGTFH 152
Query: 858 EAYNMSKL 881
E+ N + L
Sbjct: 153 ESLNFASL 160
>UniRef50_A0LFE6 Cluster: Pyruvate dehydrogenase; n=1;
Syntrophobacter fumaroxidans MPOB|Rep: Pyruvate
dehydrogenase - Syntrophobacter fumaroxidans (strain DSM
10017 / MPOB)
Length = 320
Score = 44.0 bits (99), Expect = 0.005
Identities = 18/45 (40%), Positives = 24/45 (53%)
Frame = +3
Query: 756 PVGXRIGFAPXYRADGGXTFALYGDGXANXGQFFEAYNMSKLWGL 890
P+ + FA YR T +GDG A+ G F EA N++ LW L
Sbjct: 122 PIAAGVAFAQKYRKQKNVTVCFFGDGAADEGSFHEALNLAALWDL 166
Score = 41.1 bits (92), Expect = 0.039
Identities = 28/123 (22%), Positives = 51/123 (41%), Gaps = 3/123 (2%)
Frame = +1
Query: 418 EDALKLYEQLTILRRIETASGNLYK-EKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVITA 594
E L++ + + RR E L + E + G L +GQ ++
Sbjct: 6 EKLLEMLRSMLLTRRFEEKLTELCQIEGKVPGMMILCTGQEAVAAGVCAALEPQDVIVPN 65
Query: 595 YRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGP--CICTDATSMVATGIVGAQVPLGX 768
+R HG G +++E G+RTG ++GK G + ++ T +VG +P+
Sbjct: 66 HRSHGHLLARGADPNALMAECFGKRTGFNKGKSGTLHVAVPEVNALCTTTVVGGGIPIAA 125
Query: 769 XLA 777
+A
Sbjct: 126 GVA 128
>UniRef50_Q00TN9 Cluster: Pyruvate dehydrogenase E1 component beta;
n=3; Ostreococcus|Rep: Pyruvate dehydrogenase E1
component beta - Ostreococcus tauri
Length = 835
Score = 42.3 bits (95), Expect = 0.017
Identities = 34/119 (28%), Positives = 44/119 (36%), Gaps = 2/119 (1%)
Frame = +1
Query: 409 LXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVI 588
L ED K Y + + R E Y IRGF HL +GQ
Sbjct: 132 LSDEDLSKAYYMMQLCRDFENECNQAYMAGKIRGFMHLDNGQESIPALLNDAIRKDDLKH 191
Query: 589 TAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDATSMVATG--IVGAQVP 759
+ YR H GV V++EL G+ G RG G D + G +V Q+P
Sbjct: 192 SYYRDHCHAIACGVDSGAVMAELFGKDGGTCRGTGGSMHVYDMDTNFQGGWALVAEQLP 250
>UniRef50_A5V4J0 Cluster: Pyruvate dehydrogenase; n=2; Sphingomonas
wittichii RW1|Rep: Pyruvate dehydrogenase - Sphingomonas
wittichii RW1
Length = 327
Score = 41.9 bits (94), Expect = 0.022
Identities = 24/71 (33%), Positives = 31/71 (43%), Gaps = 2/71 (2%)
Frame = +3
Query: 684 GQGRSMHLY--GRNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFF 857
G+G MHL + G P+ + +A G T A +GDG AN G
Sbjct: 99 GKGGPMHLTYPAKGIMVTTGIVGSTAPIANGLAWAAKLEGKGRVTIANFGDGAANIGAVH 158
Query: 858 EAYNMSKLWGL 890
EA NM+ LW L
Sbjct: 159 EAMNMAALWQL 169
Score = 37.1 bits (82), Expect = 0.63
Identities = 20/45 (44%), Positives = 25/45 (55%), Gaps = 2/45 (4%)
Frame = +1
Query: 649 SELTGRRTGCSRGKEGPCICTDATS--MVATGIVGAQVPLGXXLA 777
+E+ GR TG +GK GP T MV TGIVG+ P+ LA
Sbjct: 87 AEIAGRVTGACKGKGGPMHLTYPAKGIMVTTGIVGSTAPIANGLA 131
>UniRef50_A4VXG8 Cluster: Pyruvate/2-oxoglutarate dehydrogenase
complex, dehydrogenase (E1) component, eukaryotic type,
alpha subunit; n=40; Streptococcus|Rep:
Pyruvate/2-oxoglutarate dehydrogenase complex,
dehydrogenase (E1) component, eukaryotic type, alpha
subunit - Streptococcus suis (strain 05ZYH33)
Length = 337
Score = 41.9 bits (94), Expect = 0.022
Identities = 25/126 (19%), Positives = 52/126 (41%), Gaps = 2/126 (1%)
Frame = +1
Query: 406 TLXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSV 585
++ E L ++ ++ +R ++ L + ++G H G+ +
Sbjct: 18 SITKEQHLDMFLKMQQIRDVDMKLNKLVRRGFVQGMTHFSVGEEAAAVGPIAGLTDEDII 77
Query: 586 ITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDAT--SMVATGIVGAQVP 759
+ +R HG G+ + +++EL G+ TG S+G+ G + + + GIVG
Sbjct: 78 FSHHRGHGHVIAKGIDINGMMAELAGKATGTSKGRGGSMHLANVEKGNFGSNGIVGGGYA 137
Query: 760 LGXXLA 777
L A
Sbjct: 138 LAVGAA 143
Score = 35.9 bits (79), Expect = 1.5
Identities = 20/71 (28%), Positives = 28/71 (39%), Gaps = 2/71 (2%)
Frame = +3
Query: 684 GQGRSMHLYG--RNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFF 857
G+G SMHL + +G NG + Y A GD N G F
Sbjct: 111 GRGGSMHLANVEKGNFGSNGIVGGGYALAVGAALTQQYLGTDNIVIAFSGDSATNEGSFH 170
Query: 858 EAYNMSKLWGL 890
E+ N++ +W L
Sbjct: 171 ESMNLAAVWNL 181
>UniRef50_Q2BFQ9 Cluster: Putative uncharacterized protein; n=1;
Bacillus sp. NRRL B-14911|Rep: Putative uncharacterized
protein - Bacillus sp. NRRL B-14911
Length = 668
Score = 41.5 bits (93), Expect = 0.029
Identities = 30/116 (25%), Positives = 49/116 (42%), Gaps = 3/116 (2%)
Frame = +1
Query: 409 LXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVI 588
L E +Y+++ +R +E +L+ + + G H GQ V
Sbjct: 14 LSQETIDSMYKKMITIRTLEETLLDLFSKGELFGTTHTSIGQEANAVASMAHIKNGDVVF 73
Query: 589 TAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGP---CICTDATSMVATGIVG 747
+ +RCHG G V +++E+ GR TG G+ G C T+ + GIVG
Sbjct: 74 SNHRCHGHYIAYGAPVDQLIAEVMGRVTGVVGGRGGSQHICYNDFYTNGIQGGIVG 129
>UniRef50_Q479Q2 Cluster: Dehydrogenase, E1 component; n=2;
Rhodocyclaceae|Rep: Dehydrogenase, E1 component -
Dechloromonas aromatica (strain RCB)
Length = 320
Score = 41.1 bits (92), Expect = 0.039
Identities = 33/121 (27%), Positives = 51/121 (42%), Gaps = 2/121 (1%)
Frame = +1
Query: 421 DALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVITAYR 600
D L+LYEQL ++R E A + I G C GQ ++T +R
Sbjct: 9 DPLRLYEQLLLIRAYENAIVRGSTDGRIPGTC-TSVGQEAAAVGAINALEADDLILTNHR 67
Query: 601 CHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGP--CICTDATSMVATGIVGAQVPLGXXL 774
G G +L+E+ GRR G +G+ G + ++ T IVG ++ L +
Sbjct: 68 SAGHLLARGADPGRMLAEVMGRRDGYCKGRSGSLHISAKELGVVLTTTIVGGELSLAPGV 127
Query: 775 A 777
A
Sbjct: 128 A 128
>UniRef50_Q0LRY7 Cluster: Dehydrogenase, E1 component:Transketolase,
central region:Transketolase-like; n=3; cellular
organisms|Rep: Dehydrogenase, E1
component:Transketolase, central
region:Transketolase-like - Caulobacter sp. K31
Length = 680
Score = 41.1 bits (92), Expect = 0.039
Identities = 35/140 (25%), Positives = 56/140 (40%), Gaps = 10/140 (7%)
Frame = +1
Query: 388 VPATSATLXSEDALK------LYEQLTILRRIETASGNLYKEKIIR--GFCHLYSGQXXX 543
+P T+ EDA K ++ ++ +R E + L + R G HL +GQ
Sbjct: 1 MPGTNPRATKEDAAKAAFLSEMFGKICFVRAFEEEALRLTQANPPRVAGSMHLCAGQEVV 60
Query: 544 XXXXXXXXXXXXSVITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPC-ICTDAT 720
V+ YR HGW G+ V++E+ R TG + G+ G + T
Sbjct: 61 PVAAMEALGDEDQVVCTYRGHGWALAAGLDPEAVMAEICQRSTGLNGGRAGSAYMMAPHT 120
Query: 721 SMVA-TGIVGAQVPLGXXLA 777
+ IVGA + +A
Sbjct: 121 RFIGENSIVGAGTTIACGVA 140
>UniRef50_Q7N3C2 Cluster: Similar to 3-methyl-2-oxobutanoate
dehydrogenase; n=1; Photorhabdus luminescens subsp.
laumondii|Rep: Similar to 3-methyl-2-oxobutanoate
dehydrogenase - Photorhabdus luminescens subsp.
laumondii
Length = 650
Score = 40.3 bits (90), Expect = 0.068
Identities = 24/71 (33%), Positives = 30/71 (42%)
Frame = +3
Query: 684 GQGRSMHLYGRNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFFEA 863
G+G S HL F+ NG PV FA R D + A GDG G +E
Sbjct: 89 GRGGSQHLCKEGFFS-NGIQGGILPVATGAAFAKKLRHDNSISIAFIGDGTLGEGVVYEV 147
Query: 864 YNMSKLWGLAL 896
N++ W L L
Sbjct: 148 LNIAAKWDLPL 158
Score = 35.9 bits (79), Expect = 1.5
Identities = 27/110 (24%), Positives = 43/110 (39%), Gaps = 1/110 (0%)
Frame = +1
Query: 451 ILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVITAYRCHGWTYLMGV 630
++R E A LY + G H GQ V + +RCHG
Sbjct: 11 LIRETEEALLRLYSTGELHGTVHTCIGQELTGAIVCKFLKKNDWVFSNHRCHGHFLSRTG 70
Query: 631 SVLXVLSELTGRRTGCSRGKEG-PCICTDATSMVATGIVGAQVPLGXXLA 777
V +++E+ G+ TG G+ G +C + + GI G +P+ A
Sbjct: 71 DVTGLIAEVMGKETGVCGGRGGSQHLCKE--GFFSNGIQGGILPVATGAA 118
>UniRef50_Q98FT3 Cluster: Acetoin dehydrogenase (TPP-dependent)
alpha chain; n=6; Bacteria|Rep: Acetoin dehydrogenase
(TPP-dependent) alpha chain - Rhizobium loti
(Mesorhizobium loti)
Length = 342
Score = 39.9 bits (89), Expect = 0.089
Identities = 22/71 (30%), Positives = 31/71 (43%), Gaps = 2/71 (2%)
Frame = +3
Query: 684 GQGRSMHL--YGRNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFF 857
G+G SMH+ + G NG P+ + G + +GDG N G F
Sbjct: 114 GRGGSMHIADVAKGNLGANGIVGGGIPIAVGAALSSKMMKTGKVVVSFFGDGANNEGAFH 173
Query: 858 EAYNMSKLWGL 890
EA NM+ +W L
Sbjct: 174 EALNMAAVWKL 184
>UniRef50_Q83X26 Cluster: Probable pyruvate dehydrogenase
alpha-subunit; n=1; Streptomyces rochei|Rep: Probable
pyruvate dehydrogenase alpha-subunit - Streptomyces
rochei (Streptomyces parvullus)
Length = 326
Score = 39.5 bits (88), Expect = 0.12
Identities = 25/90 (27%), Positives = 41/90 (45%), Gaps = 1/90 (1%)
Frame = +1
Query: 430 KLYEQLTILRRIETASGNLYK-EKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVITAYRCH 606
+L + +R IE ++Y+ E+ +R HL GQ V + +RCH
Sbjct: 5 QLLRTMVRIRCIEEEIADVYRDEQQMRTPVHLSIGQEAVAVGVCAALRTEDVVYSGHRCH 64
Query: 607 GWTYLMGVSVLXVLSELTGRRTGCSRGKEG 696
G + +++EL GR TGC+ G+ G
Sbjct: 65 AHYLAKGGGLGAMVAELYGRETGCAAGRGG 94
>UniRef50_Q1NYL5 Cluster: Pyruvate dehydrogenase E1 component alpha
subunit; n=1; Candidatus Sulcia muelleri str. Hc
(Homalodisca coagulata)|Rep: Pyruvate dehydrogenase E1
component alpha subunit - Candidatus Sulcia muelleri
str. Hc (Homalodisca coagulata)
Length = 58
Score = 39.1 bits (87), Expect = 0.16
Identities = 17/43 (39%), Positives = 28/43 (65%)
Frame = +1
Query: 406 TLXSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQ 534
T+ ++ LK Y+ ++ R+ E +LY ++ IRGF HLY+GQ
Sbjct: 3 TINNDIYLKWYKDMSFWRKFEDKCRSLYLKQKIRGFLHLYNGQ 45
>UniRef50_Q748I3 Cluster: Dehydrogenase, E1 component, alpha and
beta subunits; n=1; Geobacter sulfurreducens|Rep:
Dehydrogenase, E1 component, alpha and beta subunits -
Geobacter sulfurreducens
Length = 652
Score = 37.9 bits (84), Expect = 0.36
Identities = 22/76 (28%), Positives = 32/76 (42%)
Frame = +3
Query: 669 DRLLPGQGRSMHLYGRNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXG 848
D + G G S HL+ NF+ NG PV A + + + GDG G
Sbjct: 95 DGVCGGVGGSQHLHTENFFS-NGIQGGMVPVAAGRALANALQGNNAISVVFIGDGTLGEG 153
Query: 849 QFFEAYNMSKLWGLAL 896
+E +N++ W L L
Sbjct: 154 VIYETFNIASKWQLPL 169
>UniRef50_Q97YF6 Cluster: Pyruvate dehydrogenase, alpha subunit
(Lipoamide); n=2; Sulfolobaceae|Rep: Pyruvate
dehydrogenase, alpha subunit (Lipoamide) - Sulfolobus
solfataricus
Length = 345
Score = 37.9 bits (84), Expect = 0.36
Identities = 22/75 (29%), Positives = 33/75 (44%), Gaps = 1/75 (1%)
Frame = +3
Query: 675 LLPGQGRSMHLYGRNF-YGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQ 851
L G+G MHL+ ++ + +G + P FA Y + G+G AN G
Sbjct: 119 LCKGKGGHMHLFDKSKNFACSGIVGASFPQAAGAAFAFKYLGKDNVAISFAGEGAANHGT 178
Query: 852 FFEAYNMSKLWGLAL 896
F E N++ W L L
Sbjct: 179 FAETLNIASAWELPL 193
>UniRef50_Q3WCG3 Cluster: Pyruvate dehydrogenase; n=4;
Actinomycetales|Rep: Pyruvate dehydrogenase - Frankia
sp. EAN1pec
Length = 332
Score = 37.1 bits (82), Expect = 0.63
Identities = 22/67 (32%), Positives = 35/67 (52%), Gaps = 2/67 (2%)
Frame = +1
Query: 583 VITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICT--DATSMVATGIVGAQV 756
++T YR GV ++ + E+ GR+ G RGK G D+ M++TGIVG+
Sbjct: 67 LVTTYRGLHDLIGKGVPLVEIYGEMLGRQVGSGRGKGGTMHIARPDSGVMLSTGIVGSGP 126
Query: 757 PLGXXLA 777
P+ +A
Sbjct: 127 PVAVGMA 133
Score = 36.7 bits (81), Expect = 0.83
Identities = 25/74 (33%), Positives = 32/74 (43%), Gaps = 3/74 (4%)
Frame = +3
Query: 684 GQGRSMHLYGRNFYG---GNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQF 854
G+G +MH+ R G G PV + A + T +GDG N G F
Sbjct: 101 GKGGTMHI-ARPDSGVMLSTGIVGSGPPVAVGMAMAARRKGLDRVTAVSFGDGATNTGSF 159
Query: 855 FEAYNMSKLWGLAL 896
EA NM+ LW L L
Sbjct: 160 HEAANMAALWDLPL 173
>UniRef50_Q49108 Cluster: Pyruvate dehydrogenase EI alpha subunit;
n=5; Mollicutes|Rep: Pyruvate dehydrogenase EI alpha
subunit - Mycoplasma capricolum
Length = 370
Score = 36.3 bits (80), Expect = 1.1
Identities = 16/37 (43%), Positives = 21/37 (56%)
Frame = +3
Query: 771 IGFAPXYRADGGXTFALYGDGXANXGQFFEAYNMSKL 881
I FA YR GG GDG ++ G+ +EA N +KL
Sbjct: 147 IAFADKYRKTGGVVVTTTGDGGSSEGETYEAMNFAKL 183
>UniRef50_Q1AZ54 Cluster: Pyruvate dehydrogenase; n=1; Rubrobacter
xylanophilus DSM 9941|Rep: Pyruvate dehydrogenase -
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Length = 325
Score = 35.9 bits (79), Expect = 1.5
Identities = 18/55 (32%), Positives = 24/55 (43%)
Frame = +3
Query: 726 GGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFFEAYNMSKLWGL 890
G G C+ P+ + YR +GDG AN G F EA N + +W L
Sbjct: 119 GTLGGCF---PIAAGAALSAKYRGTDQVCLCFFGDGTANRGTFHEAANAASVWKL 170
>UniRef50_Q8YDW3 Cluster: 2-OXOISOVALERATE DEHYDROGENASE BETA
SUBUNIT; n=10; Bacteria|Rep: 2-OXOISOVALERATE
DEHYDROGENASE BETA SUBUNIT - Brucella melitensis
Length = 729
Score = 35.5 bits (78), Expect = 1.9
Identities = 22/73 (30%), Positives = 29/73 (39%), Gaps = 2/73 (2%)
Frame = +3
Query: 684 GQGRSMHLYGRNFYGGNGNCWCAGPVGXRIGFAPXYR--ADGGXTFALYGDGXANXGQFF 857
G+G SMHL N G V G A +R G + +GDG N G
Sbjct: 138 GRGGSMHLRWAESGNLGTNAIVGGGVPMAAGAAWAHRRAGKGDVVYTYFGDGATNIGSVL 197
Query: 858 EAYNMSKLWGLAL 896
E N++ W L +
Sbjct: 198 ETMNLAAAWKLPI 210
>UniRef50_A6UDY5 Cluster: Dehydrogenase E1 component; n=2;
Alphaproteobacteria|Rep: Dehydrogenase E1 component -
Sinorhizobium medicae WSM419
Length = 342
Score = 35.5 bits (78), Expect = 1.9
Identities = 20/71 (28%), Positives = 29/71 (40%), Gaps = 2/71 (2%)
Frame = +3
Query: 684 GQGRSMHL--YGRNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFF 857
G+G SMH+ G N P G + + + A +GDG G +
Sbjct: 97 GKGGSMHIADMALGHLGANAIVGGGIPAVIGAGLSSRHLKQDSVSIAFFGDGAMQQGILY 156
Query: 858 EAYNMSKLWGL 890
E+ NM+ LW L
Sbjct: 157 ESMNMASLWNL 167
>UniRef50_Q9K3H0 Cluster: Putative pyruvate dehydrogenase alpha
subunit; n=2; Bacteria|Rep: Putative pyruvate
dehydrogenase alpha subunit - Streptomyces coelicolor
Length = 323
Score = 35.1 bits (77), Expect = 2.5
Identities = 22/67 (32%), Positives = 29/67 (43%)
Frame = +3
Query: 684 GQGRSMHLYGRNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFFEA 863
G G S H+Y R+ Y G + PV +G G GDG G +EA
Sbjct: 118 GVGGSQHIY-RDRYLSTGVQGQSLPVAVGVGLHLKQAEPGRIAVVHIGDGTWGEGAVYEA 176
Query: 864 YNMSKLW 884
NM++LW
Sbjct: 177 LNMAQLW 183
>UniRef50_Q83DQ6 Cluster: Dehydrogenase, E1 component, alpha
subunit; n=3; Coxiella burnetii|Rep: Dehydrogenase, E1
component, alpha subunit - Coxiella burnetii
Length = 368
Score = 35.1 bits (77), Expect = 2.5
Identities = 14/42 (33%), Positives = 21/42 (50%)
Frame = +3
Query: 771 IGFAPXYRADGGXTFALYGDGXANXGQFFEAYNMSKLWGLAL 896
+ +A YR + GDG + G F+EA N++ W L L
Sbjct: 148 VAYAVKYRKQARAVLTICGDGGTSKGDFYEAINLAGCWQLPL 189
>UniRef50_Q02C52 Cluster: Pyruvate dehydrogenase; n=1; Solibacter
usitatus Ellin6076|Rep: Pyruvate dehydrogenase -
Solibacter usitatus (strain Ellin6076)
Length = 340
Score = 35.1 bits (77), Expect = 2.5
Identities = 31/131 (23%), Positives = 57/131 (43%), Gaps = 3/131 (2%)
Frame = +1
Query: 394 ATSATLXSEDALKLYEQLTILRRIETA-SGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXX 570
+ + +L +E A K + ++R +E LY++ I G ++ GQ
Sbjct: 16 SAAGSLQAELAHKCLYYMLLMREVEDRIERKLYRQGKILGGVYVGRGQEAIPVGSALVAV 75
Query: 571 XXXSVITAYRCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDATSMVATGI--V 744
+ ++R ++ GVS VL++ GR G +RG++G D + V + I +
Sbjct: 76 PEDVMFPSHRDMAVFFIRGVSARRVLAQYMGRLGGLTRGRDGNMHMGDMSVNVVSIISAL 135
Query: 745 GAQVPLGXXLA 777
A VP+ A
Sbjct: 136 AATVPVATGAA 146
>UniRef50_Q4SR72 Cluster: Chromosome 11 SCAF14528, whole genome
shotgun sequence; n=3; Clupeocephala|Rep: Chromosome 11
SCAF14528, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 236
Score = 34.3 bits (75), Expect = 4.4
Identities = 16/42 (38%), Positives = 22/42 (52%), Gaps = 5/42 (11%)
Frame = -3
Query: 753 LRTNNSRC-----HHRSCVRTNAWTFLAPGATGPAPRQLREH 643
LR + S C H+R C N W +++PG T P+ L EH
Sbjct: 118 LRRSGSPCMDSVKHYRICCLQNGWVYISPGLTFPSLHHLVEH 159
>UniRef50_A1SN84 Cluster: Pyruvate dehydrogenase; n=12;
Bacteria|Rep: Pyruvate dehydrogenase - Nocardioides sp.
(strain BAA-499 / JS614)
Length = 344
Score = 33.9 bits (74), Expect = 5.9
Identities = 22/76 (28%), Positives = 33/76 (43%), Gaps = 1/76 (1%)
Frame = +3
Query: 666 QDRLLPGQGRSMHLYGRNFYGGNGNCWCAG-PVGXRIGFAPXYRADGGXTFALYGDGXAN 842
+D L G+G MHL+ + + G P FA + A+ G+G AN
Sbjct: 117 EDGLGRGRGGHMHLFDPDTHFSCSGIIAEGYPPALGQAFAFHRQGTDRIAVAVTGEGAAN 176
Query: 843 XGQFFEAYNMSKLWGL 890
G F E+ N++ W L
Sbjct: 177 QGAFHESLNLAARWSL 192
>UniRef50_Q319T4 Cluster: Pyruvate dehydrogenase; n=1;
Prochlorococcus marinus str. MIT 9312|Rep: Pyruvate
dehydrogenase - Prochlorococcus marinus (strain MIT
9312)
Length = 347
Score = 33.5 bits (73), Expect = 7.8
Identities = 29/125 (23%), Positives = 50/125 (40%), Gaps = 4/125 (3%)
Frame = +1
Query: 418 EDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQXXXXXXXXXXXXXXXSVITAY 597
++ L++ ++ ++R E + ++ G HL GQ V A+
Sbjct: 26 DELLEMLSKMILIRNAEYKIAKGREFGLVGGPVHLGVGQEAIPVGISQYLNNQDKVFGAH 85
Query: 598 RCHGWTYLMGVSVLXVLSELTGRRTGCSRGKEGPCICTDAT--SMVATGIVGAQVPL--G 765
R H +G+ + SE+ + +G S+G G + + IVG VPL G
Sbjct: 86 RSHSHILSLGIDLKSFFSEILAKSSGISKGMGGSMHLFGGSVGFCGSVPIVGGTVPLAVG 145
Query: 766 XXLAS 780
LAS
Sbjct: 146 TALAS 150
>UniRef50_Q0RVK8 Cluster: Probable pyruvate dehydrogenase; n=1;
Rhodococcus sp. RHA1|Rep: Probable pyruvate
dehydrogenase - Rhodococcus sp. (strain RHA1)
Length = 344
Score = 33.5 bits (73), Expect = 7.8
Identities = 16/56 (28%), Positives = 24/56 (42%)
Frame = +3
Query: 723 YGGNGNCWCAGPVGXRIGFAPXYRADGGXTFALYGDGXANXGQFFEAYNMSKLWGL 890
YG G P+ + + R +G+G +N G F EA NM+ +W L
Sbjct: 131 YGTTGVLGANIPIAAGVAYGVQQRGLDEVVVCGFGEGTSNRGAFHEALNMAAIWDL 186
>UniRef50_Q0RLC2 Cluster: Pyruvate dehydrogenase E1 component, alpha
subunit; n=2; Bacteria|Rep: Pyruvate dehydrogenase E1
component, alpha subunit - Frankia alni (strain ACN14a)
Length = 342
Score = 33.5 bits (73), Expect = 7.8
Identities = 13/45 (28%), Positives = 22/45 (48%)
Frame = +3
Query: 756 PVGXRIGFAPXYRADGGXTFALYGDGXANXGQFFEAYNMSKLWGL 890
P+ + + R T +GDG +N G F E+ N++ +W L
Sbjct: 137 PIANGLALSAQLRGTDQVTVVNFGDGASNIGAFHESLNLASIWRL 181
>UniRef50_Q0MX87 Cluster: Acetoin dehydrogenase alpha-subunit; n=2;
Bacteria|Rep: Acetoin dehydrogenase alpha-subunit -
consortium cosmid clone pGZ1
Length = 344
Score = 33.5 bits (73), Expect = 7.8
Identities = 23/75 (30%), Positives = 34/75 (45%), Gaps = 4/75 (5%)
Frame = +3
Query: 684 GQGRSMHL--YGRNFYGGNGNCWCAGPVGXRIGFAPXYRADGGXTFAL--YGDGXANXGQ 851
G+G SMH+ + G NG P+ +G A R G + A+ +GDG N G
Sbjct: 113 GKGGSMHIADFSVGMLGANGVVAAGIPIA--VGAAQSMRVQGRDSIAVCFFGDGALNRGP 170
Query: 852 FFEAYNMSKLWGLAL 896
F E N + + L +
Sbjct: 171 FGEGLNWAAAFRLPM 185
>UniRef50_A3SJ75 Cluster: 2-oxoisovalerate dehydrogenase beta
subunit; n=1; Roseovarius nubinhibens ISM|Rep:
2-oxoisovalerate dehydrogenase beta subunit -
Roseovarius nubinhibens ISM
Length = 746
Score = 33.5 bits (73), Expect = 7.8
Identities = 20/69 (28%), Positives = 31/69 (44%), Gaps = 2/69 (2%)
Frame = +3
Query: 684 GQGRSMHLYGRNFYGGNGNCWCAGPVGXRIGFA--PXYRADGGXTFALYGDGXANXGQFF 857
G+G SMHL N G + +G+A R + + A +GDG G +
Sbjct: 153 GRGGSMHLREPEAGVLGSNAIVGGNIPHAVGYALADKMRGERAISVAFFGDGAMQIGTAY 212
Query: 858 EAYNMSKLW 884
EA N++ L+
Sbjct: 213 EAMNLAALY 221
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 684,074,604
Number of Sequences: 1657284
Number of extensions: 11387265
Number of successful extensions: 27128
Number of sequences better than 10.0: 82
Number of HSP's better than 10.0 without gapping: 25646
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 27046
length of database: 575,637,011
effective HSP length: 100
effective length of database: 409,908,611
effective search space used: 84441173866
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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