Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fdpeP18_F_L14
(1230 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q16798 Cluster: NADP-dependent malic enzyme, mitochondr... 325 1e-87
UniRef50_P48163 Cluster: NADP-dependent malic enzyme; n=63; Euka... 318 1e-85
UniRef50_P06801 Cluster: NADP-dependent malic enzyme; n=52; cell... 318 2e-85
UniRef50_A7T6B8 Cluster: Predicted protein; n=1; Nematostella ve... 317 3e-85
UniRef50_P23368 Cluster: NAD-dependent malic enzyme, mitochondri... 313 5e-84
UniRef50_A2ZQ54 Cluster: Malic enzyme; n=9; Oryza sativa|Rep: Ma... 298 2e-79
UniRef50_P16243 Cluster: NADP-dependent malic enzyme, chloroplas... 295 2e-78
UniRef50_Q4S0L0 Cluster: Malic enzyme; n=2; Tetraodon nigrovirid... 293 6e-78
UniRef50_A0L5P5 Cluster: Malate dehydrogenase (Oxaloacetate-deca... 284 3e-75
UniRef50_Q89G76 Cluster: Malic enzyme; n=3; cellular organisms|R... 277 4e-73
UniRef50_A7CWP9 Cluster: Malate dehydrogenase (Oxaloacetate-deca... 263 6e-69
UniRef50_Q86NT5 Cluster: Malic enzyme; n=2; Drosophila melanogas... 254 3e-66
UniRef50_Q0AIF8 Cluster: Malate dehydrogenase (Oxaloacetate-deca... 253 6e-66
UniRef50_P78715 Cluster: Malic enzyme, hydrogenosomal precursor;... 253 6e-66
UniRef50_A7PC00 Cluster: Chromosome chr2 scaffold_11, whole geno... 251 3e-65
UniRef50_Q8D911 Cluster: NAD-dependent malic enzyme; n=187; cell... 250 7e-65
UniRef50_A1ZAF7 Cluster: Malic enzyme; n=5; Sophophora|Rep: Mali... 247 4e-64
UniRef50_Q016K2 Cluster: NADP dependent malic enzyme; n=2; Ostre... 247 5e-64
UniRef50_Q8I8I4 Cluster: Malic enzyme; n=4; Eukaryota|Rep: Malic... 239 1e-61
UniRef50_Q875H8 Cluster: Malic enzyme; n=1; Mucor circinelloides... 239 1e-61
UniRef50_A7IMB8 Cluster: Malate dehydrogenase (Oxaloacetate-deca... 234 3e-60
UniRef50_P37221 Cluster: NAD-dependent malic enzyme 62 kDa isofo... 232 2e-59
UniRef50_A2EKE3 Cluster: Malic enzyme; n=14; Trichomonadidae|Rep... 228 2e-58
UniRef50_Q00XN9 Cluster: Malic enzyme; n=2; Ostreococcus|Rep: Ma... 224 3e-57
UniRef50_Q4QAQ6 Cluster: Malic enzyme, putative; n=20; Trypanoso... 221 2e-56
UniRef50_UPI0000D9F768 Cluster: PREDICTED: similar to Y48B6A.12,... 217 4e-55
UniRef50_A6SA55 Cluster: Malic enzyme; n=2; Sclerotiniaceae|Rep:... 217 5e-55
UniRef50_Q5BX10 Cluster: Malic enzyme; n=1; Schistosoma japonicu... 215 1e-54
UniRef50_Q4X1Z2 Cluster: NADP-dependent malic enzyme MaeA; n=11;... 213 1e-53
UniRef50_Q01AM5 Cluster: NADP+-dependent malic enzyme; n=2; Ostr... 212 2e-53
UniRef50_Q4PC56 Cluster: Malic enzyme; n=1; Ustilago maydis|Rep:... 212 2e-53
UniRef50_Q9HE50 Cluster: Malic enzyme; n=6; Pezizomycotina|Rep: ... 211 3e-53
UniRef50_Q7SHJ8 Cluster: Malic enzyme; n=12; Pezizomycotina|Rep:... 210 6e-53
UniRef50_P45868 Cluster: Probable NAD-dependent malic enzyme 2; ... 210 6e-53
UniRef50_A3QW96 Cluster: Malic enzyme; n=10; Tigriopus californi... 208 3e-52
UniRef50_A1SVL3 Cluster: Malic enzyme aka malate dehydrogenase (... 206 7e-52
UniRef50_Q9RYN4 Cluster: Malate oxidoreductase; n=6; Deinococci|... 205 2e-51
UniRef50_A0Q531 Cluster: NAD-dependent malic enzyme; n=10; Franc... 202 1e-50
UniRef50_A4RQC9 Cluster: Malic enzyme; n=2; Ostreococcus|Rep: Ma... 201 3e-50
UniRef50_A3BK03 Cluster: Malic enzyme; n=2; Oryza sativa|Rep: Ma... 200 6e-50
UniRef50_Q5CS07 Cluster: Malic enzyme; n=2; Cryptosporidium|Rep:... 198 2e-49
UniRef50_A2QY66 Cluster: Malic enzyme; n=2; cellular organisms|R... 197 4e-49
UniRef50_Q7K3R0 Cluster: Malic enzyme; n=2; Sophophora|Rep: Mali... 186 8e-46
UniRef50_Q6AL43 Cluster: Related to NAD-dependent malic enzyme; ... 185 2e-45
UniRef50_Q95061 Cluster: Malic enzyme; n=2; Giardia intestinalis... 180 7e-44
UniRef50_Q8Y5Y8 Cluster: Lmo1915 protein; n=15; Firmicutes|Rep: ... 180 9e-44
UniRef50_P36013 Cluster: NAD-dependent malic enzyme, mitochondri... 175 3e-42
UniRef50_Q5K758 Cluster: Malic enzyme; n=1; Filobasidiella neofo... 174 4e-42
UniRef50_P40375 Cluster: NAD-dependent malic enzyme; n=3; Schizo... 174 4e-42
UniRef50_A6XP71 Cluster: Malic enzyme protein 2; n=2; Mucoromyco... 173 6e-42
UniRef50_Q48796 Cluster: Malolactic enzyme; n=49; Bacteria|Rep: ... 173 1e-41
UniRef50_Q5KBK5 Cluster: Nad-dependent malic enzyme, putative; n... 172 1e-41
UniRef50_A4SKB8 Cluster: NAD-dependent malic enzyme; n=2; Aeromo... 170 7e-41
UniRef50_Q5KEY3 Cluster: Malic enzyme; n=1; Filobasidiella neofo... 169 2e-40
UniRef50_A4RZU1 Cluster: Malic enzyme; n=2; Ostreococcus|Rep: Ma... 157 4e-37
UniRef50_A3YYQ0 Cluster: Malate oxidoreductase; n=1; Synechococc... 149 2e-34
UniRef50_Q2HCG7 Cluster: Malic enzyme; n=1; Chaetomium globosum|... 145 2e-33
UniRef50_A5C6I9 Cluster: Malic enzyme; n=1; Vitis vinifera|Rep: ... 118 4e-25
UniRef50_Q9S4T5 Cluster: NAD-malate oxidoreductase homolog; n=15... 90 1e-16
UniRef50_Q8S484 Cluster: Putative NADP-dependent malic enzyme; n... 61 7e-08
UniRef50_Q3W7J3 Cluster: Malate dehydrogenase; n=1; Frankia sp. ... 43 0.014
UniRef50_P54572 Cluster: Probable NAD-dependent malic enzyme 1; ... 42 0.033
UniRef50_Q8U225 Cluster: Malate oxidoreductase; n=41; cellular o... 42 0.043
UniRef50_UPI0000DB7FF6 Cluster: PREDICTED: hypothetical protein,... 40 0.099
UniRef50_Q5Y0M3 Cluster: Malate oxidoreductase; n=8; cellular or... 40 0.13
UniRef50_Q2KKD0 Cluster: Oxalacetate decarboxylase; n=11; Lactob... 39 0.23
UniRef50_A0DE35 Cluster: Malic enzyme; n=3; Paramecium tetraurel... 39 0.23
UniRef50_Q4T5P0 Cluster: Malic enzyme; n=1; Tetraodon nigrovirid... 38 0.70
UniRef50_Q8R7R6 Cluster: Malic enzyme; n=10; cellular organisms|... 37 1.2
UniRef50_Q9HKY7 Cluster: Malate oxidoreductase (Malic enzyme) re... 37 1.2
UniRef50_Q0STR8 Cluster: Malate oxidoreductase; n=2; Clostridium... 36 1.6
UniRef50_Q4PDI7 Cluster: Putative uncharacterized protein; n=1; ... 35 4.9
UniRef50_Q2STW7 Cluster: Putative uncharacterized protein; n=1; ... 34 6.5
UniRef50_Q116W6 Cluster: Putative uncharacterized protein; n=1; ... 34 6.5
UniRef50_Q08PM3 Cluster: Hemin ABC transporter, periplasmic hemi... 34 6.5
UniRef50_A1CKF3 Cluster: Stress response protein (Ish1), putativ... 34 6.5
UniRef50_Q4SHK3 Cluster: Chromosome 5 SCAF14581, whole genome sh... 34 8.6
UniRef50_Q5SLE4 Cluster: CBS domain protein; n=7; Bacteria|Rep: ... 34 8.6
UniRef50_Q5C370 Cluster: Malic enzyme; n=1; Schistosoma japonicu... 34 8.6
>UniRef50_Q16798 Cluster: NADP-dependent malic enzyme, mitochondrial
precursor; n=15; Bilateria|Rep: NADP-dependent malic
enzyme, mitochondrial precursor - Homo sapiens (Human)
Length = 604
Score = 325 bits (799), Expect = 1e-87
Identities = 148/236 (62%), Positives = 183/236 (77%)
Frame = +3
Query: 147 GLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIY 326
G D ++P LNKGMAFT+EER LGIHGL+PP +Q+ Q+ +R ++ L+KYI
Sbjct: 50 GYDVTRNPHLNKGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYII 109
Query: 327 LMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVY 506
LM L DRNE LFYR + +V + MPIVYTPTVGLACQ +GL +RRPRGLFITIHDKGH+
Sbjct: 110 LMTLQDRNEKLFYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHLA 169
Query: 507 DVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPITID 686
+L +WPE +++A+VVTDGERILGLGDLG GMGIPVGKLALYTA GG+ P QCLP+ +D
Sbjct: 170 TMLNSWPEDNIKAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLD 229
Query: 687 VGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDFGNA 854
VGTN + +L DPLYIGL+ +RV G YD+L DEFM+AV ++G NCL+ FEDF NA
Sbjct: 230 VGTNNEELLRDPLYIGLKHQRVHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANA 285
Score = 39.5 bits (88), Expect = 0.17
Identities = 17/22 (77%), Positives = 18/22 (81%)
Frame = +2
Query: 857 AFRLLXKYRNKYXTFNDNIXGT 922
AFRLL KYRNKY FND+I GT
Sbjct: 287 AFRLLNKYRNKYCMFNDDIQGT 308
>UniRef50_P48163 Cluster: NADP-dependent malic enzyme; n=63;
Eukaryota|Rep: NADP-dependent malic enzyme - Homo
sapiens (Human)
Length = 572
Score = 318 bits (782), Expect = 1e-85
Identities = 143/230 (62%), Positives = 176/230 (76%)
Frame = +3
Query: 162 KHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGLL 341
++P LNK +AFT+EERQ L IHGLLPP +QE QV + + + ++Y+ LM L
Sbjct: 20 RNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYLLLMDLQ 79
Query: 342 DRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLKN 521
DRNE LFYR + ++ + MPIVYTPTVGLACQ++ LV+R+PRGLFITIHD+GH+ VL
Sbjct: 80 DRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDRGHIASVLNA 139
Query: 522 WPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPITIDVGTNT 701
WPE ++AIVVTDGERILGLGDLG GMGIPVGKLALYTA GG+ P +CLP+ +DVGT
Sbjct: 140 WPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGMNPQECLPVILDVGTEN 199
Query: 702 QSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDFGN 851
+ +L DPLYIGLRQRRVRG +YD+ DEFM AV +YG NCL+ FEDF N
Sbjct: 200 EELLKDPLYIGLRQRRVRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFAN 249
Score = 40.3 bits (90), Expect = 0.099
Identities = 17/22 (77%), Positives = 19/22 (86%)
Frame = +2
Query: 857 AFRLLXKYRNKYXTFNDNIXGT 922
AFRLL KYRN+Y TFND+I GT
Sbjct: 252 AFRLLNKYRNQYCTFNDDIQGT 273
>UniRef50_P06801 Cluster: NADP-dependent malic enzyme; n=52;
cellular organisms|Rep: NADP-dependent malic enzyme -
Mus musculus (Mouse)
Length = 572
Score = 318 bits (781), Expect = 2e-85
Identities = 146/230 (63%), Positives = 174/230 (75%)
Frame = +3
Query: 162 KHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGLL 341
+ P LNK +AFT+EERQ L IHGLLPP + +QE QV + +R + ++Y+ LM L
Sbjct: 20 RDPHLNKDLAFTLEERQQLNIHGLLPPCIISQELQVLRIIKNFERLNSDFDRYLLLMDLQ 79
Query: 342 DRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLKN 521
DRNE LFY + +V + MPIVYTPTVGLACQ++ L +R+PRGLFI+IHDKGH+ VL
Sbjct: 80 DRNEKLFYSVLMSDVEKFMPIVYTPTVGLACQQYSLAFRKPRGLFISIHDKGHIASVLNA 139
Query: 522 WPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPITIDVGTNT 701
WPE V+AIVVTDGERILGLGDLG GMGIPVGKLALYTA GG+ P QCLPIT+DVGT
Sbjct: 140 WPEDVVKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGVNPQQCLPITLDVGTEN 199
Query: 702 QSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDFGN 851
+ +L DPLYIGLR RRVRGP+YD DEFM A +YG NCL+ FEDF N
Sbjct: 200 EELLKDPLYIGLRHRRVRGPEYDAFLDEFMEAASSKYGMNCLIQFEDFAN 249
Score = 43.6 bits (98), Expect = 0.011
Identities = 19/24 (79%), Positives = 20/24 (83%)
Frame = +2
Query: 851 RXAFRLLXKYRNKYXTFNDNIXGT 922
R AFRLL KYRNKY TFND+I GT
Sbjct: 250 RNAFRLLNKYRNKYCTFNDDIQGT 273
>UniRef50_A7T6B8 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 365
Score = 317 bits (779), Expect = 3e-85
Identities = 142/223 (63%), Positives = 176/223 (78%)
Frame = +3
Query: 141 LSGLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKY 320
+ G D ++ LNKG+AFT+EERQ+LGIHGLLPP V +QE Q + + R N L KY
Sbjct: 13 IRGTDIMRDSHLNKGLAFTLEERQILGIHGLLPPCVISQEIQAQRVYRELQRKPNDLEKY 72
Query: 321 IYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGH 500
I LM LL+RNE LF+R + D E+MPIVYTPTVGLAC+K+G+++RRPRGLFI+IHDKGH
Sbjct: 73 IQLMALLERNESLFFRVLFDYTEELMPIVYTPTVGLACRKYGMIFRRPRGLFISIHDKGH 132
Query: 501 VYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPIT 680
+ D++ NWP T+V+AIV+TDGERILGLGDLG CGMGIPVGKLALYT GGI P CLP+
Sbjct: 133 IRDIVSNWPTTEVKAIVMTDGERILGLGDLGCCGMGIPVGKLALYTVCGGIDPEGCLPVM 192
Query: 681 IDVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRR 809
IDVGTN + +LDDP YIG+RQ+R DYDEL DEF++A ++R
Sbjct: 193 IDVGTNNEELLDDPFYIGVRQKRCNTEDYDELIDEFIQAALQR 235
>UniRef50_P23368 Cluster: NAD-dependent malic enzyme, mitochondrial
precursor; n=53; Eumetazoa|Rep: NAD-dependent malic
enzyme, mitochondrial precursor - Homo sapiens (Human)
Length = 584
Score = 313 bits (769), Expect = 5e-84
Identities = 136/229 (59%), Positives = 180/229 (78%)
Frame = +3
Query: 165 HPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGLLD 344
+P NKGMAFT++ERQ+LG+ GLLPP+++TQ+ Q ++ + +PL KYIY+MG+ +
Sbjct: 31 NPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQE 90
Query: 345 RNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLKNW 524
RNE LFYR + D++ +MPIVYTPTVGLAC ++G ++RRP+GLFI+I D+GHV ++ NW
Sbjct: 91 RNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNW 150
Query: 525 PETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPITIDVGTNTQ 704
PE V+A+VVTDGERILGLGDLG GMGIPVGKL LYTA GI+P +CLP+ IDVGT+
Sbjct: 151 PENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIRPDRCLPVCIDVGTDNI 210
Query: 705 SMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDFGN 851
++L DP Y+GL Q+R R YD+L DEFM+A+ RYG+N L+ FEDFGN
Sbjct: 211 ALLKDPFYMGLYQKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGN 259
Score = 37.9 bits (84), Expect = 0.53
Identities = 16/22 (72%), Positives = 17/22 (77%)
Frame = +2
Query: 857 AFRLLXKYRNKYXTFNDNIXGT 922
AFR L KYR KY TFND+I GT
Sbjct: 262 AFRFLRKYREKYCTFNDDIQGT 283
>UniRef50_A2ZQ54 Cluster: Malic enzyme; n=9; Oryza sativa|Rep: Malic
enzyme - Oryza sativa subsp. japonica (Rice)
Length = 613
Score = 298 bits (732), Expect = 2e-79
Identities = 135/236 (57%), Positives = 179/236 (75%)
Frame = +3
Query: 144 SGLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYI 323
SG L+ P NKG+AF+ +ER + GLLPP V +Q+ QV+ ++ +Y PL +Y+
Sbjct: 99 SGYTLLRDPHHNKGLAFSEKERDAHYLRGLLPPAVVSQDLQVKKIMHNLRQYSVPLQRYM 158
Query: 324 YLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHV 503
+M L +RNE LFY+ + DNV E++P+VYTPTVG ACQK+G ++R+P+GL++++ DKG V
Sbjct: 159 AMMDLQERNERLFYKLLIDNVEELLPVVYTPTVGEACQKYGSIFRQPQGLYVSLKDKGKV 218
Query: 504 YDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPITI 683
DVL+NWPE +++ IVVTDGERILGLGDLG GMGIPVGKL+LYTALGG++P CLPITI
Sbjct: 219 LDVLRNWPERNIQVIVVTDGERILGLGDLGCQGMGIPVGKLSLYTALGGVRPSACLPITI 278
Query: 684 DVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDFGN 851
DVGTN + +L+D YIGLRQRR G +Y EL +EFM AV + YG+ L+ FEDF N
Sbjct: 279 DVGTNNEQLLNDEFYIGLRQRRATGKEYHELMEEFMSAVKQIYGEKVLIQFEDFAN 334
>UniRef50_P16243 Cluster: NADP-dependent malic enzyme, chloroplast
precursor; n=79; Magnoliophyta|Rep: NADP-dependent malic
enzyme, chloroplast precursor - Zea mays (Maize)
Length = 636
Score = 295 bits (723), Expect = 2e-78
Identities = 136/240 (56%), Positives = 177/240 (73%)
Frame = +3
Query: 132 TSGLSGLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPL 311
TS SG L+ P NKG+AFT EER + GLLPP V +QE Q++ ++ +Y+ PL
Sbjct: 92 TSVASGYTLLRDPHHNKGLAFTEEERDGHYLRGLLPPAVLSQELQIKKFMNTLRQYQTPL 151
Query: 312 NKYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHD 491
+YI +M L + +E LFY+ + DNV E++P VYTPTVG ACQK+G ++ RP+GL++++ D
Sbjct: 152 QRYIAMMNLQETDERLFYKLLIDNVVELLPFVYTPTVGEACQKYGSIFGRPQGLYVSLKD 211
Query: 492 KGHVYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCL 671
KG V +VL+NWP +++ I VTDGERILGLGDLG GMGIPVGKLALYTALGG+ P CL
Sbjct: 212 KGKVLEVLRNWPHRNIQVICVTDGERILGLGDLGCQGMGIPVGKLALYTALGGVDPSVCL 271
Query: 672 PITIDVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDFGN 851
PITIDVGTN + +L+D YIGLRQ+R G +YDEL +EFM AV + YG+ L+ FEDF N
Sbjct: 272 PITIDVGTNNEFLLNDEFYIGLRQKRATGEEYDELIEEFMSAVKQFYGEKVLIQFEDFAN 331
>UniRef50_Q4S0L0 Cluster: Malic enzyme; n=2; Tetraodon
nigroviridis|Rep: Malic enzyme - Tetraodon nigroviridis
(Green puffer)
Length = 694
Score = 293 bits (719), Expect = 6e-78
Identities = 143/257 (55%), Positives = 180/257 (70%), Gaps = 10/257 (3%)
Frame = +3
Query: 114 SGDGQPTSGLSGLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSID 293
+ +G + G D ++P LNKGMAFT+EER +GIHGLLPP +Q+ QV S +
Sbjct: 51 ASEGSVRTKKRGYDITRNPHLNKGMAFTLEERLQMGIHGLLPPCFLSQDVQVLRVMKSYE 110
Query: 294 RYENPLNKYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGL 473
NPL+KYI LM L DRNE LFYR + ++ + MPIVYTPTVGLACQ++GL +RRPRGL
Sbjct: 111 TRSNPLDKYILLMTLQDRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYGLAFRRPRGL 170
Query: 474 FITIHDKGHVYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALY-----T 638
FITIHD+GH+ +L +WPE D++A+VVTDGERILGLGDLG+ GMGIPVGKLAL
Sbjct: 171 FITIHDRGHIATMLNSWPEEDIKAVVVTDGERILGLGDLGSYGMGIPVGKLALLHRLRRR 230
Query: 639 ALGGIKPHQC-----LPITIDVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVV 803
A + P P ++ G Q +LDDPLYIGL+ +RVRG DYD L +EFM+AV
Sbjct: 231 AAAAVPPGAAGRGHRQPGSVPGGVCVQVLLDDPLYIGLKHKRVRGKDYDGLIEEFMQAVT 290
Query: 804 RRYGQNCLVXFEDFGNA 854
+YG NCL+ FEDF N+
Sbjct: 291 DKYGMNCLIQFEDFANS 307
Score = 37.9 bits (84), Expect = 0.53
Identities = 15/21 (71%), Positives = 18/21 (85%)
Frame = +2
Query: 857 AFRLLXKYRNKYXTFNDNIXG 919
AFR+L KYRN+Y TFND+I G
Sbjct: 309 AFRILNKYRNRYCTFNDDIQG 329
>UniRef50_A0L5P5 Cluster: Malate dehydrogenase
(Oxaloacetate-decarboxylating) (NADP(+)); n=1;
Magnetococcus sp. MC-1|Rep: Malate dehydrogenase
(Oxaloacetate-decarboxylating) (NADP(+)) - Magnetococcus
sp. (strain MC-1)
Length = 556
Score = 284 bits (697), Expect = 3e-75
Identities = 135/240 (56%), Positives = 173/240 (72%)
Frame = +3
Query: 132 TSGLSGLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPL 311
T + L+ L P +NKG+AFT EER L + GLLPPRV+T E Q+ + N L
Sbjct: 14 TGHANPLEILNDPYMNKGVAFTEEERDLFHLRGLLPPRVQTMEAQLGRALDNFRCKPNDL 73
Query: 312 NKYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHD 491
KYI+L GL +RNE LFYR V N+ EM+PI+YTPTVG ACQ +G ++RRP+G+FI+I+D
Sbjct: 74 EKYIFLTGLQERNETLFYRLVMTNIEEMLPIIYTPTVGKACQTYGHIFRRPQGMFISIND 133
Query: 492 KGHVYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCL 671
KG + ++L NW DVR IVVTDG RILGLGDLGA GMGIPVGKLALYTAL GI P CL
Sbjct: 134 KGRIAELLGNWVHKDVRVIVVTDGSRILGLGDLGAHGMGIPVGKLALYTALAGIPPIHCL 193
Query: 672 PITIDVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDFGN 851
P+T+D+GTN +++ +DPLY+GL Q RV G YDE+ +EF+ AV ++ ++ FEDF N
Sbjct: 194 PVTLDMGTNNEALRNDPLYVGLPQPRVTGEIYDEMIEEFVLAVQEQF-PRAMIQFEDFSN 252
Score = 33.9 bits (74), Expect = 8.6
Identities = 14/22 (63%), Positives = 18/22 (81%)
Frame = +2
Query: 857 AFRLLXKYRNKYXTFNDNIXGT 922
AFRLL KY+++ TFND+I GT
Sbjct: 255 AFRLLEKYQDRICTFNDDIQGT 276
>UniRef50_Q89G76 Cluster: Malic enzyme; n=3; cellular organisms|Rep:
Malic enzyme - Bradyrhizobium japonicum
Length = 531
Score = 277 bits (679), Expect = 4e-73
Identities = 132/231 (57%), Positives = 164/231 (70%)
Frame = +3
Query: 159 LKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGL 338
L+ P LNKG AFT ER LG+ GLLPP V T E QV+ ++ L KY+ L L
Sbjct: 4 LRDPLLNKGTAFTEAERAALGLRGLLPPCVLTMETQVDRVLTNLRMLPTDLEKYVALNAL 63
Query: 339 LDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLK 518
DRNE LF+R V DN+ E+ PI+YTPTVGLACQK+GL+++RPRG+FI+ D+G + ++LK
Sbjct: 64 HDRNEALFFRVVVDNIDEIQPIIYTPTVGLACQKYGLIFQRPRGMFISSRDRGQIAEILK 123
Query: 519 NWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPITIDVGTN 698
NWP R IVVTDGERILGLGDLGA GMGIPVGKL+LY+A G+ P CLPI +DVGTN
Sbjct: 124 NWP-YPARLIVVTDGERILGLGDLGANGMGIPVGKLSLYSACAGVHPEHCLPIVLDVGTN 182
Query: 699 TQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDFGN 851
+ +L+DP Y+GLR+RR+ G YD DEFM A R+ L+ FEDF N
Sbjct: 183 NEELLNDPYYLGLRERRLTGEAYDSFVDEFMVA-ARKTFPGVLIQFEDFAN 232
>UniRef50_A7CWP9 Cluster: Malate dehydrogenase
(Oxaloacetate-decarboxylating) (NADP(+)); n=1;
Opitutaceae bacterium TAV2|Rep: Malate dehydrogenase
(Oxaloacetate-decarboxylating) (NADP(+)) - Opitutaceae
bacterium TAV2
Length = 561
Score = 263 bits (645), Expect = 6e-69
Identities = 127/253 (50%), Positives = 171/253 (67%)
Frame = +3
Query: 93 DRIGLWGSGDGQPTSGLSGLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVE 272
D++ G + L G L LNKG AF+ ER LG+ GLLPPRV T E+Q +
Sbjct: 6 DQVSSLGLSARGARASLRGTALLGDSVLNKGTAFSERERDALGLRGLLPPRVFTLEQQEQ 65
Query: 273 LCKLSIDRYENPLNKYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLV 452
++ + + + KYIYL L RNE LFYR + ++ EM+P+VYTPTVG AC ++G
Sbjct: 66 RALNAMAKKPSAIEKYIYLTTLQSRNETLFYRLLTNHAEEMIPLVYTPTVGQACLEYGAN 125
Query: 453 YRRPRGLFITIHDKGHVYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLAL 632
+RRPRGLFI+I D+G + ++L++WP TDVR IVVTDGERILGLGDLG GMGIPVGKLAL
Sbjct: 126 FRRPRGLFISIKDRGRIAEILRHWPITDVRMIVVTDGERILGLGDLGVLGMGIPVGKLAL 185
Query: 633 YTALGGIKPHQCLPITIDVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRY 812
Y+A G+ P CLPI +D G + +++ +DPLY+G +RVRG DYD +EF+ AV +
Sbjct: 186 YSACAGLHPSYCLPIALDAGIDNETLRNDPLYLGHPMKRVRGADYDAFLNEFVEAVKTVF 245
Query: 813 GQNCLVXFEDFGN 851
+ ++ +EDFGN
Sbjct: 246 PKT-MIQWEDFGN 257
>UniRef50_Q86NT5 Cluster: Malic enzyme; n=2; Drosophila
melanogaster|Rep: Malic enzyme - Drosophila melanogaster
(Fruit fly)
Length = 610
Score = 254 bits (623), Expect = 3e-66
Identities = 120/224 (53%), Positives = 158/224 (70%), Gaps = 1/224 (0%)
Frame = +3
Query: 177 NKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGLLDRNEH 356
NK +AFT+EERQ L IHGL+P V+T +EQ+ + + +E+ + +Y YL L E
Sbjct: 56 NKALAFTLEERQRLCIHGLMPACVRTYDEQMLAIESNFHSFESNVGRYRYLRALRQGYER 115
Query: 357 LFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLKNWP-ET 533
L+++FV+ NV ++PI+YTPTVGLAC +G++YR G+ IT HD+GH+ +L NWP
Sbjct: 116 LYFQFVSKNVHAVLPIIYTPTVGLACTVYGMLYRGMTGIHITKHDRGHMKQILSNWPMRR 175
Query: 534 DVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPITIDVGTNTQSML 713
V+AI VTDG+RILGLGDLGA GMGI VGK+ LYTAL GI P LPI +DVGTN +S+
Sbjct: 176 SVKAICVTDGQRILGLGDLGANGMGIAVGKMELYTALAGIPPSMLLPICLDVGTNNKSLH 235
Query: 714 DDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDF 845
+DPLYIGLR R++G +Y DEFM AVV +G L+ FEDF
Sbjct: 236 EDPLYIGLRDERLKGDEYVCFVDEFMEAVVSTFGDQTLIHFEDF 279
>UniRef50_Q0AIF8 Cluster: Malate dehydrogenase
(Oxaloacetate-decarboxylating) (NADP(+)); n=2;
Nitrosomonas|Rep: Malate dehydrogenase
(Oxaloacetate-decarboxylating) (NADP(+)) - Nitrosomonas
eutropha (strain C71)
Length = 536
Score = 253 bits (620), Expect = 6e-66
Identities = 121/237 (51%), Positives = 161/237 (67%)
Frame = +3
Query: 141 LSGLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKY 320
L G L P NK AFT EER+ G+ GLLP V ++Q + ++ + + KY
Sbjct: 4 LYGKTLLNDPVQNKSTAFTREEREHYGLQGLLPYGVTDIKKQQQRVLANLRNKSSNIEKY 63
Query: 321 IYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGH 500
IYL LL+RN+ LFYR + D++ E+MP+VYTPTVG AC K ++R+P+G +IT D+G
Sbjct: 64 IYLNDLLERNQQLFYRTLVDHIGEIMPLVYTPTVGEACVKLSHIFRKPQGFYITPEDRGE 123
Query: 501 VYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPIT 680
+ LKNWPETDV+ IVVTDGERILGLGDLGA GMGIP+GK++LY A GI P +C+P+
Sbjct: 124 IISRLKNWPETDVQIIVVTDGERILGLGDLGANGMGIPIGKISLYVACAGIYPDRCMPVM 183
Query: 681 IDVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDFGN 851
+DVGT Q++ +DPLY+G R+ G DY L DEF+ AV RY + L+ FEDF +
Sbjct: 184 LDVGTGNQALREDPLYLGYPYPRLVGQDYLSLVDEFVEAVQHRY-PDALIQFEDFSS 239
>UniRef50_P78715 Cluster: Malic enzyme, hydrogenosomal precursor;
n=1; Neocallimastix frontalis|Rep: Malic enzyme,
hydrogenosomal precursor - Neocallimastix frontalis
(Rumen fungus)
Length = 592
Score = 253 bits (620), Expect = 6e-66
Identities = 115/234 (49%), Positives = 160/234 (68%)
Frame = +3
Query: 144 SGLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYI 323
+GLD L P LNKG AFT +E+ LGI GL+PPR ++ E Q + CK ++D+ +PL K+I
Sbjct: 46 TGLDILNDPKLNKGSAFTADEKDRLGIRGLVPPRPQSLEAQYKRCKTNLDKISDPLEKFI 105
Query: 324 YLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHV 503
YL L +RNE L+Y+ + +N E+ PI+YTP VG ACQKF ++ + RG++ + D+G +
Sbjct: 106 YLNHLQNRNETLYYKMILENFVELAPIIYTPVVGEACQKFHKIFTQTRGMYFSTADRGQM 165
Query: 504 YDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPITI 683
V NWP DV IVVTDG RILGLGDLGA GM IP+GKL LY GGI P LPI +
Sbjct: 166 SAVAANWPYDDVDVIVVTDGSRILGLGDLGAGGMQIPIGKLTLYVCGGGINPRNVLPIVL 225
Query: 684 DVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDF 845
DVGTN + +L+DPLY+G++ R++G ++ DE++ A+ R+ ++ FEDF
Sbjct: 226 DVGTNNKELLNDPLYLGMQHPRLQGEEFHAFVDEWVSAITDRF-PKAVIQFEDF 278
>UniRef50_A7PC00 Cluster: Chromosome chr2 scaffold_11, whole genome
shotgun sequence; n=3; Vitis vinifera|Rep: Chromosome
chr2 scaffold_11, whole genome shotgun sequence - Vitis
vinifera (Grape)
Length = 573
Score = 251 bits (614), Expect = 3e-65
Identities = 116/216 (53%), Positives = 153/216 (70%)
Frame = +3
Query: 144 SGLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYI 323
SG L+ P NKG+AFT +ER + GLLPP V Q+ Q + ++ +Y+ PL +Y+
Sbjct: 196 SGYTLLRDPHHNKGLAFTEKERDAHYLRGLLPPAVLNQDLQEKRLMHNLRQYKVPLQRYM 255
Query: 324 YLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHV 503
+M +RNE LFY+ + DNV E++P+VYTPTVG ACQK+G ++RRP+ L+I G +
Sbjct: 256 AMMDFQERNERLFYKLLIDNVEELLPVVYTPTVGEACQKYGSIFRRPQSLYIIDFFMGKI 315
Query: 504 YDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPITI 683
+VLKNWPE ++ IVVT+GERILGLGDLG GMGIPVGKL+LYT LGG+ P CLP+TI
Sbjct: 316 LEVLKNWPERSIQVIVVTNGERILGLGDLGCQGMGIPVGKLSLYTTLGGLHPSVCLPVTI 375
Query: 684 DVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFM 791
DVGTN + +L D YIGL+QRR G +Y EL E +
Sbjct: 376 DVGTNNEQLLKDEFYIGLKQRRATGQEYAELLHELI 411
>UniRef50_Q8D911 Cluster: NAD-dependent malic enzyme; n=187;
cellular organisms|Rep: NAD-dependent malic enzyme -
Vibrio vulnificus
Length = 562
Score = 250 bits (611), Expect = 7e-65
Identities = 119/229 (51%), Positives = 156/229 (68%)
Frame = +3
Query: 159 LKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGL 338
L P LNKG AF+ EER + GLLP +T +EQVE + +E+ ++K+IYL +
Sbjct: 18 LSTPLLNKGSAFSAEERISFNLEGLLPETTETIQEQVERAYMQYKAFESDMDKHIYLRNI 77
Query: 339 LDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLK 518
D NE LFYR V +++ EMMPI+YTPTVG AC+ F +YRR RGLF++ ++ + D+L
Sbjct: 78 QDTNETLFYRLVQNHITEMMPIIYTPTVGAACENFSNIYRRGRGLFVSYANRDRIDDILN 137
Query: 519 NWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPITIDVGTN 698
N +V+ IVVTDGERILGLGD G GMGIP+GKL+LYTA GGI P LPI +DVGTN
Sbjct: 138 NASNHNVKVIVVTDGERILGLGDQGIGGMGIPIGKLSLYTACGGISPAYTLPIVLDVGTN 197
Query: 699 TQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDF 845
L DP+Y+G R R+ G DYD +EF++AV RR+ + L+ FEDF
Sbjct: 198 NPQRLADPMYMGWRHPRITGADYDAFVEEFIQAVQRRW-PDALIQFEDF 245
>UniRef50_A1ZAF7 Cluster: Malic enzyme; n=5; Sophophora|Rep: Malic
enzyme - Drosophila melanogaster (Fruit fly)
Length = 603
Score = 247 bits (605), Expect = 4e-64
Identities = 109/223 (48%), Positives = 157/223 (70%)
Frame = +3
Query: 177 NKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGLLDRNEH 356
NKG+AFTI+ERQ LGI GL+P V++ ++Q+ + + + ++ YL + R+
Sbjct: 48 NKGLAFTIKERQRLGIMGLMPCSVRSMDDQMNAALANFEARPTDIARFTYLSAVHHRHRR 107
Query: 357 LFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLKNWPETD 536
L+YRF+ +N+ + +PIVYTPTVG +GL +++ LFI+IHDKGH+ D++ NW +
Sbjct: 108 LYYRFIKENIEKSLPIVYTPTVGDVVATYGLNFQQAISLFISIHDKGHIRDLMHNWVDEG 167
Query: 537 VRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPITIDVGTNTQSMLD 716
V+AI VTDG R+LGLGD+GA MGI +GK+ LYTALG I P +P+ +DVGT+ Q++L
Sbjct: 168 VKAICVTDGGRVLGLGDMGANAMGISLGKMILYTALGSIPPSTLMPVCLDVGTDNQALLQ 227
Query: 717 DPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDF 845
DPLY+G R RV+GP+YDEL DEFM + V+ +G N + FEDF
Sbjct: 228 DPLYVGARIPRVKGPEYDELVDEFMESAVKCFGNNTFIHFEDF 270
>UniRef50_Q016K2 Cluster: NADP dependent malic enzyme; n=2;
Ostreococcus|Rep: NADP dependent malic enzyme -
Ostreococcus tauri
Length = 641
Score = 247 bits (604), Expect = 5e-64
Identities = 115/238 (48%), Positives = 164/238 (68%)
Frame = +3
Query: 141 LSGLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKY 320
+SG++ L+ NKGM+F +ER L + GLLPP V Q QVE + R + + K+
Sbjct: 81 ISGVELLRSGRYNKGMSFARDERDRLNLRGLLPPAVFDQATQVERVIERLRRVTSGVEKH 140
Query: 321 IYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGH 500
+L L +RNE LFYR V D++ E++P++ PTV C++ GL+YR+PRGL++++ DKG
Sbjct: 141 AWLPALYERNERLFYRVVKDHLEELLPVLAEPTVWQVCREAGLMYRQPRGLYVSMQDKGS 200
Query: 501 VYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPIT 680
VY +LKNWP +V+A+V+TDG+R+ G+GDLG GM V K +L+TALGG+ P LPI
Sbjct: 201 VYRLLKNWPVRNVKAVVLTDGQRVTGIGDLGVQGMPAAVSKASLFTALGGLDPADVLPIC 260
Query: 681 IDVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDFGNA 854
IDVGT+ Q++L+D YIGLRQ+RV G Y+EL DE + + RR+G L+ FE+F NA
Sbjct: 261 IDVGTDNQTLLEDKFYIGLRQKRVGGEAYEELLDEVVSGLKRRFGPRVLLCFEEFSNA 318
>UniRef50_Q8I8I4 Cluster: Malic enzyme; n=4; Eukaryota|Rep: Malic
enzyme - Mastigamoeba balamuthi (Phreatamoeba balamuthi)
Length = 568
Score = 239 bits (585), Expect = 1e-61
Identities = 124/242 (51%), Positives = 154/242 (63%)
Frame = +3
Query: 126 QPTSGLSGLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYEN 305
+P GL+G L G AFT EER+ L I GLLP V+T E Q +
Sbjct: 30 RPADGLAGPSWLTLAPT--GTAFTTEERKALRIRGLLPHAVETIEAQAARAYAQLTSQPT 87
Query: 306 PLNKYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITI 485
PL KY+YL L RN+ LF+ V +V E +P+VYTPTVG C KF +R P GL+IT
Sbjct: 88 PLLKYLYLSQLSQRNQTLFFYLVQHHVEECVPLVYTPTVGEGCTKFSAEFRNPTGLYITP 147
Query: 486 HDKGHVYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQ 665
DKGHV ++L+NWP +V IVVTDG RILGLGDLG+ GMGIP+GKL LY A G +P +
Sbjct: 148 EDKGHVAEILENWPH-EVEIIVVTDGGRILGLGDLGSNGMGIPIGKLHLYIACAGFRPDR 206
Query: 666 CLPITIDVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDF 845
LP+ IDVGTN Q +LDDP+Y+G+R+ R+ +Y L +EFM A VR CLV FEDF
Sbjct: 207 TLPVMIDVGTNRQELLDDPMYLGVRKARLGDAEYFALLEEFMTA-VRAKWPRCLVQFEDF 265
Query: 846 GN 851
N
Sbjct: 266 PN 267
>UniRef50_Q875H8 Cluster: Malic enzyme; n=1; Mucor
circinelloides|Rep: Malic enzyme - Mucor circinelloides
Length = 617
Score = 239 bits (584), Expect = 1e-61
Identities = 110/233 (47%), Positives = 159/233 (68%)
Frame = +3
Query: 147 GLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIY 326
G++ L P L+KG AF+I ER+ L I GL+PPR + ++Q+ K ++D E PL K+++
Sbjct: 50 GVNLLHDPLLSKGTAFSIAERERLSIRGLVPPRCQEMDKQLLRIKRNLDACETPLAKFVF 109
Query: 327 LMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVY 506
L L DRNE L+Y+ + +++ E+ I+YTPTVGLA Q +YRR RG++ + D+G +
Sbjct: 110 LAALHDRNETLYYKIIMEHLEELAGIIYTPTVGLASQMSHSIYRRSRGMYFSSQDRGQMS 169
Query: 507 DVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPITID 686
++ NWP V IVVTDG R+LGLGDLGA GM IP+GKL+LY A GGI+P LP+ +D
Sbjct: 170 AMVYNWPHDKVDVIVVTDGSRVLGLGDLGANGMEIPIGKLSLYVAAGGIRPRAVLPVVLD 229
Query: 687 VGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDF 845
VGTN Q +L+DPLY+G+ R+ G +Y DE++ A+ R+ + L+ FEDF
Sbjct: 230 VGTNNQDLLNDPLYLGMSHPRLEGEEYYSFIDEWVTAITSRW-PDTLIQFEDF 281
>UniRef50_A7IMB8 Cluster: Malate dehydrogenase
(Oxaloacetate-decarboxylating) (NADP(+)); n=2;
Alphaproteobacteria|Rep: Malate dehydrogenase
(Oxaloacetate-decarboxylating) (NADP(+)) - Xanthobacter
sp. (strain Py2)
Length = 550
Score = 234 bits (573), Expect = 3e-60
Identities = 113/239 (47%), Positives = 158/239 (66%)
Frame = +3
Query: 129 PTSGLSGLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENP 308
P S LSGL+ L P NKG A+T ++R+ LG+ GLLP V+T + QVE +D ++
Sbjct: 13 PKSNLSGLNLLHDPVRNKGTAYTRDDRRQLGLEGLLPHAVETLDRQVERVLDHLDHVKDE 72
Query: 309 LNKYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIH 488
L++Y YLM L RNE +FY+ V + +PI+Y PTV AC+ FG +YRRPRG++IT H
Sbjct: 73 LDQYSYLMDLEARNETVFYKAVMSDPKRFIPILYDPTVADACEAFGNLYRRPRGMYITRH 132
Query: 489 DKGHVYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQC 668
KG + +VL+NWP+ D+R + V+ G RILGLGD+GA GMGIP+GKL LYTA + P
Sbjct: 133 MKGRMAEVLRNWPQKDIRFVCVSTGGRILGLGDIGANGMGIPIGKLQLYTACAAVPPDVL 192
Query: 669 LPITIDVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDF 845
LP+ D+GT+ + + DP Y+G R+ V + DEL +EF++AV + C V FED+
Sbjct: 193 LPVLFDIGTSNEHLRADPFYLGTREAPVSEAELDELTEEFVQAVNEVF-PGCCVHFEDW 250
>UniRef50_P37221 Cluster: NAD-dependent malic enzyme 62 kDa isoform,
mitochondrial precursor; n=41; Eukaryota|Rep:
NAD-dependent malic enzyme 62 kDa isoform, mitochondrial
precursor - Solanum tuberosum (Potato)
Length = 626
Score = 232 bits (567), Expect = 2e-59
Identities = 116/242 (47%), Positives = 157/242 (64%), Gaps = 10/242 (4%)
Frame = +3
Query: 150 LDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQV-----ELCKLSIDRYENPLN 314
LD L P NKG AF+ ER L I GLLPP V + E+Q+ +L +L + + P +
Sbjct: 50 LDILHDPWFNKGTAFSFTERDRLHIRGLLPPNVMSFEQQIARFMADLKRLEVQARDGPSD 109
Query: 315 KYIY-----LMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFI 479
Y+ L L DRNE L+Y+ + +N+ E PIVYTPTVGL CQK+ ++RRPRG++
Sbjct: 110 PYVLAKWRILNRLHDRNETLYYKVLMENIEEYAPIVYTPTVGLVCQKYSGLFRRPRGMYF 169
Query: 480 TIHDKGHVYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKP 659
+ D+G + ++ NWP V IVVTDG RILGLGDLG G+GI +GKL LY A GI P
Sbjct: 170 SAEDRGEMMSMVYNWPADQVDMIVVTDGSRILGLGDLGIQGIGIAIGKLDLYVAAAGINP 229
Query: 660 HQCLPITIDVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFE 839
+ LP+ IDVGT+ +++L DPLY+GL+ R+ G +Y E+ DEFM AV R+ + +V FE
Sbjct: 230 QRVLPVMIDVGTDNENLLKDPLYLGLQDHRLDGEEYIEVIDEFMEAVFTRW-PHVIVQFE 288
Query: 840 DF 845
DF
Sbjct: 289 DF 290
Score = 35.9 bits (79), Expect = 2.1
Identities = 14/26 (53%), Positives = 19/26 (73%)
Frame = +2
Query: 845 RERXAFRLLXKYRNKYXTFNDNIXGT 922
+ + AF+LL +YRN Y FND+I GT
Sbjct: 291 QSKWAFKLLQRYRNNYRMFNDDIQGT 316
>UniRef50_A2EKE3 Cluster: Malic enzyme; n=14; Trichomonadidae|Rep:
Malic enzyme - Trichomonas vaginalis G3
Length = 567
Score = 228 bits (558), Expect = 2e-58
Identities = 113/235 (48%), Positives = 152/235 (64%), Gaps = 1/235 (0%)
Frame = +3
Query: 144 SGLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYI 323
+G+ L+ LNKG AFT EER + GLLP +V T++EQ + + PL KYI
Sbjct: 23 TGMTLLQDGDLNKGTAFTKEERDRFNLRGLLPYKVFTKDEQAARIRRQFELMPTPLLKYI 82
Query: 324 YLMGLLDRNEHLFYRFVADNVAE-MMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGH 500
+L ++N F+RF+ + E MPI+YTPTVG ACQK+ + RG++IT D G
Sbjct: 83 FLANEREKNSQSFWRFLFTHPPEETMPILYTPTVGEACQKWATHRQSYRGIYITPEDSGK 142
Query: 501 VYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPIT 680
+ D+L+N+P D+R IVVTD RILGLGDLGA G+GIPVGKL LYT +G + P Q LP+
Sbjct: 143 IKDILRNYPRQDIRCIVVTDAGRILGLGDLGASGLGIPVGKLMLYTLIGQVDPDQTLPVQ 202
Query: 681 IDVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDF 845
+D+GT+ + +L DPLY G R RVRG ++ + EF+ AV +G CLV FEDF
Sbjct: 203 LDMGTDRKEILADPLYHGWRHPRVRGAEHLKFVTEFVEAVKEVFGDTCLVQFEDF 257
>UniRef50_Q00XN9 Cluster: Malic enzyme; n=2; Ostreococcus|Rep: Malic
enzyme - Ostreococcus tauri
Length = 639
Score = 224 bits (548), Expect = 3e-57
Identities = 108/233 (46%), Positives = 149/233 (63%)
Frame = +3
Query: 147 GLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIY 326
G++ L +P NKG +FT ER+ LG+ GL+PPR +Q E PL+K+ +
Sbjct: 81 GIEVLHNPVYNKGTSFTASERERLGVRGLVPPRFFPIGQQATKIWAQNQSLERPLDKWQH 140
Query: 327 LMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVY 506
L L DRNE LFYR V D++ E+ PI+YTPTVG AC F + RR RG++ ++ D+G +
Sbjct: 141 LQDLKDRNETLFYRLVHDHIEELAPIIYTPTVGDACLNFSKLLRRARGMYFSVDDRGDIN 200
Query: 507 DVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPITID 686
++ NW + V IVVTDG RILGLGDLG GMGI GK+ LY A GG P LP+ +D
Sbjct: 201 SMMFNWKRS-VSVIVVTDGSRILGLGDLGTNGMGISQGKVDLYVAGGGFDPQHVLPVVLD 259
Query: 687 VGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDF 845
VGTN + +L+DP Y+G+ ++R+ G +Y +EF+R V R+ N L+ FEDF
Sbjct: 260 VGTNNEDLLNDPYYLGVPRKRLEGEEYYAFIEEFIRGVRNRW-PNALIQFEDF 311
>UniRef50_Q4QAQ6 Cluster: Malic enzyme, putative; n=20;
Trypanosomatidae|Rep: Malic enzyme, putative -
Leishmania major
Length = 573
Score = 221 bits (541), Expect = 2e-56
Identities = 104/235 (44%), Positives = 157/235 (66%)
Frame = +3
Query: 147 GLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIY 326
G+D+L++ NKG AFT ER + + GLLPP V+T ++QVE ++R+ P+N+Y
Sbjct: 19 GVDYLRNRFTNKGTAFTAAERSHMNVEGLLPPSVETLDDQVERYWDQLNRFNEPINRYQL 78
Query: 327 LMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVY 506
L + + N L+Y + + + +PIVYTPTVG ACQ++G +Y++ GL++ + KG V
Sbjct: 79 LRNVQNTNVTLYYAILTRYLKQTLPIVYTPTVGEACQRYGDLYQKDHGLYLDVASKGKVR 138
Query: 507 DVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPITID 686
+++N +T++ IV+TDG RILGLGDLG+ G+GI +GK +LY A GG+KP + LP+ +D
Sbjct: 139 RLIQNLRKTNIDVIVITDGSRILGLGDLGSNGIGISIGKCSLYVAAGGVKPSRVLPVVMD 198
Query: 687 VGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDFGN 851
VGTN + ++PLY+GLR+ R D+ L DEFM AV + + +V FEDF N
Sbjct: 199 VGTNNLELRNNPLYLGLRKPRCGDADFYALLDEFMEAVKDTW-PSAVVQFEDFSN 252
>UniRef50_UPI0000D9F768 Cluster: PREDICTED: similar to Y48B6A.12,
partial; n=1; Macaca mulatta|Rep: PREDICTED: similar to
Y48B6A.12, partial - Macaca mulatta
Length = 456
Score = 217 bits (531), Expect = 4e-55
Identities = 105/208 (50%), Positives = 138/208 (66%)
Frame = +3
Query: 228 GLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGLLDRNEHLFYRFVADNVAEMMPIV 407
GLLPP+V + Q C L + N + KYIYL L DRNE L+++ + D+VAEMMPIV
Sbjct: 34 GLLPPKVLDLDVQSRRCYLQFSQNSNDIEKYIYLESLHDRNETLYFKLLVDHVAEMMPIV 93
Query: 408 YTPTVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLKNWPETDVRAIVVTDGERILGLGD 587
YTP VG ACQ FG ++R RGL+ + +KG+ +++ N D IVVTDG RILGLGD
Sbjct: 94 YTPVVGKACQLFGHIFRNARGLYFNLSEKGNFKEMVWNSNVRDADIIVVTDGSRILGLGD 153
Query: 588 LGACGMGIPVGKLALYTALGGIKPHQCLPITIDVGTNTQSMLDDPLYIGLRQRRVRGPDY 767
LG GMGIP+GKL+LY A GI P + +P+T+DVGTN +L+D +Y+G R +RV G +Y
Sbjct: 154 LGTNGMGIPIGKLSLYVACAGINPGRTVPVTLDVGTNNPDLLNDDMYLGERHKRVDGEEY 213
Query: 768 DELXDEFMRAVVRRYGQNCLVXFEDFGN 851
DEF+ AV R+ L+ FEDF N
Sbjct: 214 YAAVDEFVDAVRSRW-PGVLIQFEDFTN 240
>UniRef50_A6SA55 Cluster: Malic enzyme; n=2; Sclerotiniaceae|Rep:
Malic enzyme - Botryotinia fuckeliana B05.10
Length = 685
Score = 217 bits (530), Expect = 5e-55
Identities = 103/229 (44%), Positives = 151/229 (65%)
Frame = +3
Query: 165 HPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGLLD 344
HP L + +IE R+ GL+PP V++ + Q C ++ + P+ KY+YL L +
Sbjct: 97 HPIL-PDTSHSIELRRKNKTLGLVPPNVESHKLQTTRCLQQLNAKKTPIEKYMYLSNLRN 155
Query: 345 RNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLKNW 524
N HLFYR V +++ ++ P++YTPTVG AC ++ +Y++P GL+++ HD+G++ +VL NW
Sbjct: 156 NNVHLFYRLVQEHLTDITPLIYTPTVGEACLRWSEIYQQPEGLYLSYHDRGNLEEVLGNW 215
Query: 525 PETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPITIDVGTNTQ 704
++DV VVTDG RILGLGDLG GMGIPVGKL+LYT GI P + LPIT+D+GTN +
Sbjct: 216 RQSDVEMTVVTDGSRILGLGDLGVNGMGIPVGKLSLYTGCAGIHPSKTLPITLDLGTNNE 275
Query: 705 SMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDFGN 851
L DPLY+G R +RV + E +E M A+ + + +V +EDF N
Sbjct: 276 KFLKDPLYMGNRMKRVSTKEEAEFMEELMVALNKMW-PGIIVQYEDFKN 323
>UniRef50_Q5BX10 Cluster: Malic enzyme; n=1; Schistosoma
japonicum|Rep: Malic enzyme - Schistosoma japonicum
(Blood fluke)
Length = 216
Score = 215 bits (526), Expect = 1e-54
Identities = 97/160 (60%), Positives = 123/160 (76%)
Frame = +3
Query: 141 LSGLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKY 320
L G+D ++ P N+G AFT+ ERQLLGIHGLLPP V T E+QV ++ + L +Y
Sbjct: 52 LLGIDVVRDPRTNRGTAFTVNERQLLGIHGLLPPSVLTLEQQVSKMLANLKNMNDNLQRY 111
Query: 321 IYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGH 500
IYL L DRNE LFY+ V ++V MP++YTPTVGLACQ++G+V+RRPRGL+ITIHD+ H
Sbjct: 112 IYLTSLQDRNEALFYKLVIEHVEYCMPLIYTPTVGLACQRYGVVFRRPRGLYITIHDRHH 171
Query: 501 VYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVG 620
+ ++L NWPE V+AIV TDGERILGLGDLGA GMGIP+G
Sbjct: 172 IPEILNNWPEPIVKAIVFTDGERILGLGDLGAYGMGIPIG 211
>UniRef50_Q4X1Z2 Cluster: NADP-dependent malic enzyme MaeA; n=11;
Pezizomycotina|Rep: NADP-dependent malic enzyme MaeA -
Aspergillus fumigatus (Sartorya fumigata)
Length = 661
Score = 213 bits (519), Expect = 1e-53
Identities = 94/215 (43%), Positives = 143/215 (66%)
Frame = +3
Query: 207 RQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGLLDRNEHLFYRFVADNV 386
R+ L +GL PPR ++ E Q C + + ++K++YL L N HLFYR V D++
Sbjct: 102 RKYLRTYGLTPPRAESYEIQKTRCLAQLALKQTAIDKFLYLSTLRKNNVHLFYRLVTDHL 161
Query: 387 AEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLKNWPETDVRAIVVTDGE 566
E+ P++YTP VG ACQK+ +Y++P G++++ D+G++ V+ NWP+ +V +TDG
Sbjct: 162 KELTPLIYTPVVGEACQKWSEIYQQPEGMYLSWEDRGNLAAVIANWPQPNVEITCITDGS 221
Query: 567 RILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPITIDVGTNTQSMLDDPLYIGLRQR 746
RILGLGDLG GMGIP+GKLALYTA GI+P LP+T+D+GT+ +++ +DPLY+G R+
Sbjct: 222 RILGLGDLGINGMGIPIGKLALYTACAGIRPEATLPLTLDLGTSNKALREDPLYMGTRRD 281
Query: 747 RVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDFGN 851
++ + E DE M A+ R+ ++ FEDF N
Sbjct: 282 KISPEEEREFMDELMAALTERW-PGIVIQFEDFKN 315
>UniRef50_Q01AM5 Cluster: NADP+-dependent malic enzyme; n=2;
Ostreococcus|Rep: NADP+-dependent malic enzyme -
Ostreococcus tauri
Length = 580
Score = 212 bits (517), Expect = 2e-53
Identities = 104/233 (44%), Positives = 146/233 (62%)
Frame = +3
Query: 147 GLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIY 326
G L+ +G+A +R+ G+ GL+P +E ++ ++ + E P KY
Sbjct: 48 GYASLRDASAYRGLA--TNDRRGKGVDGLIPAGEVGEEVEIARANAALAQCETPFEKYKQ 105
Query: 327 LMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVY 506
L+ L +E FYR + ++PI+YTPTVG AC KFG + +RP GL+++ +D G+V
Sbjct: 106 LVALQMTDESTFYRMLRSQTETLLPILYTPTVGEACVKFGTLVQRPMGLWVSSNDAGNVK 165
Query: 507 DVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPITID 686
+++NWP TDV+ V+TDGERILGLGD GA GMGI GK +Y A G+ P LPI +D
Sbjct: 166 QLIRNWPATDVKIAVITDGERILGLGDQGANGMGISAGKSMVYAAC-GVPPSALLPIQVD 224
Query: 687 VGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDF 845
GTN Q++LDDPLYIGL+Q+R R YD L DE + AV RYGQ ++ +EDF
Sbjct: 225 TGTNNQTLLDDPLYIGLKQKRDRTKAYDALLDEIVVAVRSRYGQKTIIHWEDF 277
>UniRef50_Q4PC56 Cluster: Malic enzyme; n=1; Ustilago maydis|Rep:
Malic enzyme - Ustilago maydis (Smut fungus)
Length = 634
Score = 212 bits (517), Expect = 2e-53
Identities = 106/235 (45%), Positives = 142/235 (60%), Gaps = 4/235 (1%)
Frame = +3
Query: 153 DH--LKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIY 326
DH + P N+ F+ E+R LG+ GLLPP ++ QV + PL K++
Sbjct: 77 DHRIISDPFPNQDTGFSYEKRDQLGLRGLLPPAKQSLNTQVLRVLHQLRSKSTPLEKHVM 136
Query: 327 LMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVY 506
L L N L+Y + N E++P++YTPTVG ACQKF +YRRP GL I++ DKG +
Sbjct: 137 LASLRQTNTRLYYATILANKEEILPLIYTPTVGEACQKFSHIYRRPEGLSISLEDKGKIA 196
Query: 507 DVLKNW--PETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPIT 680
+++NW P R V+TDG RILGLGDLG G GI +GKL+LY A GI P LPI
Sbjct: 197 SIVENWPVPAGSPRIAVITDGSRILGLGDLGWNGQGISIGKLSLYVAGAGIHPRATLPIV 256
Query: 681 IDVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDF 845
+D+GTN + L+DPLY+GLR+ R +Y E DE M A+ RY N ++ FEDF
Sbjct: 257 VDLGTNNKKNLEDPLYLGLRRERASTEEYIEFMDEVMHALHTRY-PNLIIQFEDF 310
>UniRef50_Q9HE50 Cluster: Malic enzyme; n=6; Pezizomycotina|Rep: Malic
enzyme - Neurospora crassa
Length = 1023
Score = 211 bits (515), Expect = 3e-53
Identities = 101/222 (45%), Positives = 140/222 (63%)
Frame = +3
Query: 180 KGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGLLDRNEHL 359
KG +FT EER + GL+P ++ E+QVE I + +++Y+YL + +N L
Sbjct: 483 KGTSFTPEERVAKNLTGLIPHVMEDSEKQVERALKMIRTRQTDIDRYLYLSTIKSQNVDL 542
Query: 360 FYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLKNWPETDV 539
FYR + D+ EMMP+VYTPT+G C ++ +Y RP L+I+I + + +L+NWP
Sbjct: 543 FYRLLMDHAKEMMPLVYTPTIGDVCLQYSTLYTRPEALYISIKQRKSIRTILRNWPYPQP 602
Query: 540 RAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPITIDVGTNTQSMLDD 719
VVTDG RILGLGDLG G+GIP+GKLALYTA GI P + LPI +D GT ++ L D
Sbjct: 603 EICVVTDGSRILGLGDLGVNGVGIPIGKLALYTAAAGIHPDKTLPIVLDCGTANETNLKD 662
Query: 720 PLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDF 845
PLY+GLRQ+R+ + E DEFM A + + +V FEDF
Sbjct: 663 PLYLGLRQKRIPVAEQQEFMDEFMEAAAEVF-PDMVVQFEDF 703
>UniRef50_Q7SHJ8 Cluster: Malic enzyme; n=12; Pezizomycotina|Rep:
Malic enzyme - Neurospora crassa
Length = 611
Score = 210 bits (513), Expect = 6e-53
Identities = 108/247 (43%), Positives = 148/247 (59%), Gaps = 2/247 (0%)
Frame = +3
Query: 114 SGDGQPTSGLSGLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSID 293
S G L G L HP NKG AFT EER+ +HGLLPP++++ E+QV+
Sbjct: 24 STSGPLECALKGTVLLNHPYFNKGSAFTKEERRDFALHGLLPPQIQSLEQQVQRAYEQYC 83
Query: 294 RYENPLNKYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGL 473
N L K ++ + ++NE LFYR + D++ EM +VYTPT G A Q + ++RRP G+
Sbjct: 84 SQPNDLAKNTFMTSMKEQNEVLFYRLLHDHLDEMFSVVYTPTEGEAIQNYSRLFRRPEGV 143
Query: 474 FITIHDKGHVYDVLKNW--PETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALG 647
F+ I+D V L W PE D+ IVVTDGE ILG+GD G G+ I + KL L T G
Sbjct: 144 FLNINDMDSVKRDLAQWGKPE-DIDYIVVTDGEEILGIGDQGCGGILISIAKLVLMTICG 202
Query: 648 GIKPHQCLPITIDVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCL 827
GI P++ LP+ +D GTN + +L D LY+GLRQ+R RG YD+ + F++A Y
Sbjct: 203 GIHPNRVLPVVLDCGTNNEELLKDDLYLGLRQKRARGDKYDDFVETFIKAARELY-PRAY 261
Query: 828 VXFEDFG 848
+ FEDFG
Sbjct: 262 IHFEDFG 268
>UniRef50_P45868 Cluster: Probable NAD-dependent malic enzyme 2;
n=37; Bacteria|Rep: Probable NAD-dependent malic enzyme
2 - Bacillus subtilis
Length = 582
Score = 210 bits (513), Expect = 6e-53
Identities = 102/246 (41%), Positives = 157/246 (63%), Gaps = 2/246 (0%)
Frame = +3
Query: 120 DGQPTSGLSGLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRY 299
+G + L G + L P LNKG+AF++EERQ LG+ GLLPP V + ++Q +
Sbjct: 26 EGHLETTLRGKEVLSIPTLNKGVAFSLEERQELGLEGLLPPTVLSLDQQAQRAYEQFQAQ 85
Query: 300 ENPLNKYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFI 479
+ L + +YL L +RNE LFY+ + +++ EM+P+VYTPTVG A Q++ YRRP+G+++
Sbjct: 86 PDRLRQNVYLSDLANRNEVLFYKLLKNHLREMLPVVYTPTVGEAIQEYSHEYRRPQGIYL 145
Query: 480 TIHDKGHVYDVLKNWPET--DVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGI 653
+I + + +N T D+ IV TD E ILG+GD G G+ I +GKLA+YTA GI
Sbjct: 146 SIDNIDGIEKAFENLHATAGDIDLIVATDSESILGIGDWGVGGINIAIGKLAVYTAAAGI 205
Query: 654 KPHQCLPITIDVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVX 833
P + +P+ +DVGTN + +L+DPLYIG + RV+G Y+ D +++A + ++ L+
Sbjct: 206 DPSRVIPVVLDVGTNNEKLLNDPLYIGNKHERVQGERYEAFIDAYVKAAL-KFFPKALLH 264
Query: 834 FEDFGN 851
+ED GN
Sbjct: 265 WEDLGN 270
>UniRef50_A3QW96 Cluster: Malic enzyme; n=10; Tigriopus
californicus|Rep: Malic enzyme - Tigriopus californicus
(Marine copepod)
Length = 322
Score = 208 bits (507), Expect = 3e-52
Identities = 106/252 (42%), Positives = 149/252 (59%), Gaps = 19/252 (7%)
Frame = +3
Query: 147 GLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDR------YENP 308
G + + P NKG+AF + ER L + GL+PPR+ + +EQ + R + P
Sbjct: 45 GRNLVSDPISNKGLAFPLSERDRLSVRGLVPPRILSIQEQERVIMDEYTRGWAARAEQEP 104
Query: 309 -------------LNKYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGL 449
+ K+ L + DRNE LFYR + DN +M PI+YTPTVG AC F
Sbjct: 105 EDEIIKSGVGPDNIRKWKVLQSVQDRNETLFYRILMDNFQDMAPIIYTPTVGWACSHFSQ 164
Query: 450 VYRRPRGLFITIHDKGHVYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLA 629
+YRRPRG++ + D+G + ++ NW +V A+V+TDG RILGLGDLG G+GI +GKL
Sbjct: 165 LYRRPRGMYFSHGDRGEMASMVYNWESDEVDAVVITDGSRILGLGDLGLGGLGISIGKLD 224
Query: 630 LYTALGGIKPHQCLPITIDVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRR 809
LY A GG P + LP+ +D+GTN Q +L+DP Y+GL+Q R+ G +Y + DE M A R
Sbjct: 225 LYVAAGGFHPRRVLPVVLDIGTNNQKLLNDPNYLGLKQPRIDGEEYYAIMDELMAATKLR 284
Query: 810 YGQNCLVXFEDF 845
+ L+ EDF
Sbjct: 285 W-PRALIQHEDF 295
>UniRef50_A1SVL3 Cluster: Malic enzyme aka malate dehydrogenase
(Oxaloacetate-decarboxylating) (NADP(+)); n=4;
Gammaproteobacteria|Rep: Malic enzyme aka malate
dehydrogenase (Oxaloacetate-decarboxylating) (NADP(+)) -
Psychromonas ingrahamii (strain 37)
Length = 571
Score = 206 bits (504), Expect = 7e-52
Identities = 103/252 (40%), Positives = 154/252 (61%), Gaps = 3/252 (1%)
Frame = +3
Query: 108 WGSGDG---QPTSGLSGLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELC 278
W +G +P S L+G + L + LNK AFT +ER+ ++GLLPPRV+T E+Q++
Sbjct: 9 WEDSEGNVFRPVS-LTGNELLNNRTLNKSTAFTYQEREDFDLNGLLPPRVQTFEDQLKRV 67
Query: 279 KLSIDRYENPLNKYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYR 458
+ KY YL L DRNE LFY ++ N+ EM PI+YTPTVG ACQ+F ++
Sbjct: 68 YQGFSASSTDIEKYQYLRALQDRNETLFYALISRNIEEMTPIIYTPTVGKACQEFSHRFQ 127
Query: 459 RPRGLFITIHDKGHVYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYT 638
RGL++T + V + + + D++ IVVTD + ILG+GD G GMGIP+GKL+LYT
Sbjct: 128 IARGLYLTTDNIHDVGSMAREFTGKDIQIIVVTDSQGILGIGDQGVGGMGIPIGKLSLYT 187
Query: 639 ALGGIKPHQCLPITIDVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQ 818
GI P C+PI +D+GT+ Q +L DP+Y+G+ ++R+ G Y F+ V+ +
Sbjct: 188 LGAGIHPDHCMPIALDIGTDNQDLLADPMYLGIPKKRLTGEPYKAFIKTFVEQ-VKLHFP 246
Query: 819 NCLVXFEDFGNA 854
++ +EDF +
Sbjct: 247 KAVLQWEDFSKS 258
>UniRef50_Q9RYN4 Cluster: Malate oxidoreductase; n=6;
Deinococci|Rep: Malate oxidoreductase - Deinococcus
radiodurans
Length = 580
Score = 205 bits (501), Expect = 2e-51
Identities = 102/233 (43%), Positives = 141/233 (60%)
Frame = +3
Query: 147 GLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIY 326
G + + P LNKG AFT EER+ G+ GLL P+V + E +E + L K++Y
Sbjct: 37 GFNLTRIPLLNKGTAFTAEEREAHGLDGLLAPQVDSLEVLIERAYREFSKRGAALEKHVY 96
Query: 327 LMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVY 506
L L DRNE LFY ++ +V EM+PIVYTPTVG A +KF +YR PRGL ++
Sbjct: 97 LRNLQDRNEVLFYALLSHHVEEMLPIVYTPTVGDAVKKFSQIYRYPRGLTLSTRTIERAE 156
Query: 507 DVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPITID 686
L N P DVR IV TD ILG+GD G GM I +GKL+LYT GG+ P + LP+ +D
Sbjct: 157 QALANVPLNDVRIIVATDSSAILGIGDQGFGGMAISIGKLSLYTVAGGVGPDKTLPVELD 216
Query: 687 VGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDF 845
VGT + +DP Y+G++ R+ G +Y D+F+ A ++RY ++ +EDF
Sbjct: 217 VGTGRADLREDPHYLGVKHERLTGEEYFAFIDKFVEATIQRY-PKAIIQWEDF 268
>UniRef50_A0Q531 Cluster: NAD-dependent malic enzyme; n=10;
Francisella tularensis|Rep: NAD-dependent malic enzyme -
Francisella tularensis subsp. novicida (strain U112)
Length = 604
Score = 202 bits (493), Expect = 1e-50
Identities = 100/238 (42%), Positives = 147/238 (61%)
Frame = +3
Query: 135 SGLSGLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLN 314
+ L+G L + LNK +AF+ EER + G LP +V++ EEQ + +D N L
Sbjct: 23 TNLTGRQLLNNRVLNKDVAFSQEERIAFDLIGYLPEKVESLEEQAIRVRRQLDLKPNSLE 82
Query: 315 KYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDK 494
KY++L L D N LFY FV +N+ E+MPI+YTPTVG A QK+ +R+ GLFI+I K
Sbjct: 83 KYVFLNRLHDLNTTLFYHFVRENLEEIMPIIYTPTVGEAVQKYSSSFRKQSGLFISISHK 142
Query: 495 GHVYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLP 674
H+ +L+ + + ++VTDGE +LG+GD G GM I +GK+ +Y A GI P + LP
Sbjct: 143 KHIARILERYEYNSIDLVLVTDGEAVLGIGDQGIGGMNISIGKIMVYVAASGIDPARVLP 202
Query: 675 ITIDVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDFG 848
+ +D+GTN ++L+ P Y+G+R RV G YDE +EF+ V R+ N + +ED G
Sbjct: 203 VQLDMGTNNDALLNAPGYLGVRLPRVSGETYDEFIEEFVTQVKARF-PNVFLHWEDLG 259
>UniRef50_A4RQC9 Cluster: Malic enzyme; n=2; Ostreococcus|Rep: Malic
enzyme - Ostreococcus lucimarinus CCE9901
Length = 549
Score = 201 bits (490), Expect = 3e-50
Identities = 98/229 (42%), Positives = 142/229 (62%)
Frame = +3
Query: 159 LKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGL 338
L P LNKG FT +R+ LG+ GLLP + +T E QV+ + +E +N+YI+L L
Sbjct: 13 LDSPSLNKGTGFTFTQRERLGLRGLLPRKYETVEIQVKRAWTQLCAFEEDMNRYIFLENL 72
Query: 339 LDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLK 518
+NE LFYR + +++ ++MPIVYTPTVG AC F +YR G++ + D G + +L
Sbjct: 73 HMQNERLFYRVLVEHLEDLMPIVYTPTVGEACINFDALYRNRCGMYFSRLDSGVMRRMLD 132
Query: 519 NWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPITIDVGTN 698
NWP + IVVTDG R+LGLGDLG GM I VGK++LY A GG P + +P+ +D+GT+
Sbjct: 133 NWPSPETEIIVVTDGGRVLGLGDLGTNGMAISVGKVSLYVASGGFDPAKSMPVCLDLGTS 192
Query: 699 TQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDF 845
++ Y+G + R+ G + + EF AV ++ NCL+ FEDF
Sbjct: 193 NVALRAHDFYLGADEPRLTGDAHLAVVTEFCLAVKDKW-PNCLIQFEDF 240
>UniRef50_A3BK03 Cluster: Malic enzyme; n=2; Oryza sativa|Rep: Malic
enzyme - Oryza sativa subsp. japonica (Rice)
Length = 635
Score = 200 bits (488), Expect = 6e-50
Identities = 112/263 (42%), Positives = 152/263 (57%), Gaps = 10/263 (3%)
Frame = +3
Query: 87 ERDRIGLWGSGDGQPTSGLSGLDHLKHPGLNKGMAFTIEERQL------LGIHGLLPPRV 248
ERDR+GL G S +D P L F E + + L + P
Sbjct: 64 ERDRLGLRGLLPPNVVSSQQQIDRFT-PTLKYQYKFHSEIQHIDAKGLALNYLNISPAIC 122
Query: 249 KTQEEQVELCKLSIDRYEN--PLNKYIYLMGLLDRNEHLFYR--FVADNVAEMMPIVYTP 416
++ + V K + D + PL K+ L L DRNE ++Y+ + DN+ E PIVYTP
Sbjct: 123 ESSQYCVNADKYARDGPSDTYPLAKWRILNRLHDRNETMYYKAEVLIDNIEEHAPIVYTP 182
Query: 417 TVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLKNWPETDVRAIVVTDGERILGLGDLGA 596
TVGL CQ + ++RRPRG++ + D+G + ++ NWP V IVVTDG RILGLGDLG
Sbjct: 183 TVGLVCQNYSGLFRRPRGMYFSAEDRGEMMSMVYNWPADQVDMIVVTDGSRILGLGDLGV 242
Query: 597 CGMGIPVGKLALYTALGGIKPHQCLPITIDVGTNTQSMLDDPLYIGLRQRRVRGPDYDEL 776
G+GI +GKL LY A GI P + LP+ IDVGTN + +L DPLY+GL++ R+ G +Y +
Sbjct: 243 HGIGIAIGKLDLYVAAAGINPQRVLPVMIDVGTNNEKLLKDPLYLGLQEHRLEGEEYVAI 302
Query: 777 XDEFMRAVVRRYGQNCLVXFEDF 845
DEFM AV R+ N +V FEDF
Sbjct: 303 IDEFMEAVFARW-PNVIVQFEDF 324
Score = 44.0 bits (99), Expect = 0.008
Identities = 18/42 (42%), Positives = 27/42 (64%)
Frame = +3
Query: 147 GLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVE 272
G D L P N+G F++ ER LG+ GLLPP V + ++Q++
Sbjct: 45 GSDILHDPWFNRGTGFSMTERDRLGLRGLLPPNVVSSQQQID 86
>UniRef50_Q5CS07 Cluster: Malic enzyme; n=2; Cryptosporidium|Rep:
Malic enzyme - Cryptosporidium parvum Iowa II
Length = 614
Score = 198 bits (484), Expect = 2e-49
Identities = 97/238 (40%), Positives = 153/238 (64%), Gaps = 4/238 (1%)
Frame = +3
Query: 141 LSGLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKY 320
L G++ L++P NKG++FT+EER+ G+ GLLP + +T +EQV +I++ ++ + KY
Sbjct: 64 LKGIELLRNPFYNKGLSFTMEERKEYGLEGLLPAKYETIDEQVSRLWTAINKIDSNIGKY 123
Query: 321 IYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGL--VYRR--PRGLFITIH 488
+L + + LF+ + ++ P+VYTPTVG C +F R GL++
Sbjct: 124 TFLENIRSSSFILFHSLLDKYFKDLTPLVYTPTVGEGCIEFSRNPTIRNWLGSGLYLNKS 183
Query: 489 DKGHVYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQC 668
KG +Y++LK++ D+ IV+TDG RILGLGDLG GMGIP+GKL+LY LGGI P +
Sbjct: 184 HKGRIYEILKDFKSDDIEIIVLTDGGRILGLGDLGLNGMGIPMGKLSLYITLGGIDPSKV 243
Query: 669 LPITIDVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFED 842
LPI++D+GTNT +L D Y+G+ ++R+ +Y L DE +A+ +R+ N ++ +ED
Sbjct: 244 LPISLDIGTNTNDILSDKYYLGICEKRIDNDEYFPLMDEITKAIFKRW-PNTVLQWED 300
>UniRef50_A2QY66 Cluster: Malic enzyme; n=2; cellular organisms|Rep:
Malic enzyme - Aspergillus niger
Length = 609
Score = 197 bits (481), Expect = 4e-49
Identities = 98/235 (41%), Positives = 144/235 (61%), Gaps = 1/235 (0%)
Frame = +3
Query: 147 GLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIY 326
G D L+ NKG AFT EER+ +HGLLPP ++T EEQV+ +N L K +
Sbjct: 57 GRDALQSCQFNKGSAFTEEERKTFKLHGLLPPNIQTLEEQVQRAYEQYSSRDNDLAKNTF 116
Query: 327 LMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVY 506
+ + +NE L+Y+ + ++ EM+ I+YTPT G A Q + ++R+P G F+ I D+ +
Sbjct: 117 MASMKAQNEVLYYKLIDTHLKEMLSIIYTPTEGDAIQNYSRLFRKPEGCFLNIRDQDRIE 176
Query: 507 DVLKNWPE-TDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPITI 683
+ L N+ +V IVV+DGE ILG+GD G + I V KLAL T GI P + LP+ +
Sbjct: 177 ECLSNFSRGEEVDYIVVSDGEEILGIGDQGVGAILISVAKLALTTLCAGIHPSRQLPVVL 236
Query: 684 DVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDFG 848
D GT+ +S+L D LY+GLRQ RVRG +YD+ ++F+ +R+ + FEDFG
Sbjct: 237 DCGTDNESLLTDELYLGLRQSRVRGEEYDQFVEKFVETARKRF-PRAYIHFEDFG 290
>UniRef50_Q7K3R0 Cluster: Malic enzyme; n=2; Sophophora|Rep: Malic
enzyme - Drosophila melanogaster (Fruit fly)
Length = 633
Score = 186 bits (454), Expect = 8e-46
Identities = 93/237 (39%), Positives = 136/237 (57%)
Frame = +3
Query: 135 SGLSGLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLN 314
S + GL L NKG+AFT+ ER++L IHGLLP V+T +EQ E+C ++ + N +
Sbjct: 68 SKVDGLWMLNQSNYNKGLAFTLNERRVLSIHGLLPVAVRTIDEQAEICSNLLESFTNNVQ 127
Query: 315 KYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDK 494
+YIYL L RN LFY + N +P+ +++ +GL+I I D
Sbjct: 128 QYIYLTYLSRRNRRLFYYLLLSNPDRFVPMTDASGSIDLLMVHRMIHSMGQGLYICIKDL 187
Query: 495 GHVYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLP 674
GHV +L NWP VR ++V++G +L +GDLG M I L GGI P CL
Sbjct: 188 GHVSQILSNWPFRCVRCLLVSNGASVLSVGDLGVDEMPILFSNLHQNVVYGGIHPAYCLA 247
Query: 675 ITIDVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDF 845
+ +DVGTN + +L+DP+Y GLR+RR YD+L +EF +V+++YG L+ +DF
Sbjct: 248 VMLDVGTNNEELLNDPMYTGLRERRCSEKLYDQLFEEFTLSVMQQYGPRALILCKDF 304
>UniRef50_Q6AL43 Cluster: Related to NAD-dependent malic enzyme;
n=1; Desulfotalea psychrophila|Rep: Related to
NAD-dependent malic enzyme - Desulfotalea psychrophila
Length = 578
Score = 185 bits (450), Expect = 2e-45
Identities = 92/223 (41%), Positives = 132/223 (59%)
Frame = +3
Query: 177 NKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGLLDRNEH 356
NK AF+ +ER G+ G LPP + E QVE C + + E+ KYI++ L DRN
Sbjct: 35 NKSTAFSSKERDDFGLQGSLPPGFRDLEAQVENCHIKLGEKESEEEKYIFIRSLFDRNVT 94
Query: 357 LFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLKNWPETD 536
L + + ++ + M I+YTPTVGLA QK+ ++R+ GL + D+L+ + D
Sbjct: 95 LAHALIQSDLEKFMGIIYTPTVGLAVQKYSAMFRQANGLHFSPDTIDQAEDILRRFAHRD 154
Query: 537 VRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPITIDVGTNTQSMLD 716
+R VVTD + ILG+GD GA G+ I +GKL LYT GI P CLPI++D+GT+ +++L
Sbjct: 155 IRVAVVTDNQGILGIGDQGAGGIAICLGKLMLYTQGAGIAPWHCLPISLDIGTDNEALLA 214
Query: 717 DPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDF 845
D Y+G RQ+R+ G +Y D F RA R N L +EDF
Sbjct: 215 DKHYLGWRQKRLVGDEYTAFIDRFARA-FRNVFPNALCQWEDF 256
>UniRef50_Q95061 Cluster: Malic enzyme; n=2; Giardia
intestinalis|Rep: Malic enzyme - Giardia lamblia
(Giardia intestinalis)
Length = 557
Score = 180 bits (438), Expect = 7e-44
Identities = 96/232 (41%), Positives = 132/232 (56%), Gaps = 1/232 (0%)
Frame = +3
Query: 159 LKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGL 338
L++ NK AFT ER+ I LP RV+T E+Q+ C+ D P K++YL L
Sbjct: 9 LRNKDCNKDTAFTAAEREAHHIVARLPARVETIEQQISRCRAQFDVLTTPTEKWLYLTRL 68
Query: 339 LDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRR-PRGLFITIHDKGHVYDVL 515
+ NE LF F + E++PIVYTPTVG AC + L+++ PRG ++ G V +
Sbjct: 69 QEVNETLFSGFCLKYLKEVLPIVYTPTVGTACSNYSLLWQGYPRGFYLNRTHLGKVKQIF 128
Query: 516 KNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPITIDVGT 695
WP + R IV TDG RILGLGDLG G I VGKL LY+ GG P LPI+ D G
Sbjct: 129 DQWPYSP-RIIVATDGTRILGLGDLGTGGHQICVGKLTLYSLGGGFAPEHTLPISFDFGC 187
Query: 696 NTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDFGN 851
NT + +DP Y+G+ ++R + Y + E + AV ++ +C+ FEDF N
Sbjct: 188 NTDKIREDPHYLGIPEKRNKDDTYYGIIKETIEAVHSKW-PDCIFQFEDFSN 238
>UniRef50_Q8Y5Y8 Cluster: Lmo1915 protein; n=15; Firmicutes|Rep:
Lmo1915 protein - Listeria monocytogenes
Length = 547
Score = 180 bits (437), Expect = 9e-44
Identities = 92/240 (38%), Positives = 142/240 (59%), Gaps = 3/240 (1%)
Frame = +3
Query: 144 SGLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYI 323
SG D++ +P LNKG AF+ EER + GLLPP ++T E+Q + I+ E PL+K+
Sbjct: 5 SGFDYMNNPLLNKGTAFSKEERASYQLDGLLPPIIETIEQQAVRIETQIENLETPLHKHR 64
Query: 324 YLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRP-RGLFITIHDKGH 500
L L + N L+Y V NV + +PI+YTPT+G A ++ Y P LF+
Sbjct: 65 LLTNLYNENRTLYYYVVTKNVTDYLPIIYTPTIGDAVIQYHKDYTAPDEALFVDAFAPEK 124
Query: 501 VYDVLKNWPET--DVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLP 674
+ +KN+ + ++ IV+TDGE +LG+GD G+ I VGKLA+YT G+ P + LP
Sbjct: 125 LSASIKNYAKNNPNIDMIVITDGEGVLGIGDWSVNGVKIAVGKLAVYTVAAGLAPDRVLP 184
Query: 675 ITIDVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDFGNA 854
+ ID GTN +++L+DPLY+G ++ R+ +YD F+ V++ ++ +EDFG A
Sbjct: 185 VVIDAGTNNETLLNDPLYLGNKRPRLSESEYDAFIASFVN-VMKEVFPKAILHWEDFGRA 243
>UniRef50_P36013 Cluster: NAD-dependent malic enzyme, mitochondrial
precursor; n=15; Saccharomycetales|Rep: NAD-dependent
malic enzyme, mitochondrial precursor - Saccharomyces
cerevisiae (Baker's yeast)
Length = 669
Score = 175 bits (425), Expect = 3e-42
Identities = 91/237 (38%), Positives = 140/237 (59%), Gaps = 1/237 (0%)
Frame = +3
Query: 141 LSGLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKY 320
L L P NKG AFT EER+ + LLPP+V T +EQ+E + + PL K
Sbjct: 98 LESFQLLNSPLFNKGSAFTQEEREAFNLEALLPPQVNTLDEQLERSYKQLCYLKTPLAKN 157
Query: 321 IYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGH 500
++ L +N+ L++ + ++ E++PI+YTPT G A + +R+P G+F+ I +
Sbjct: 158 DFMTSLRVQNKVLYFALIRRHIKELVPIIYTPTEGDAIAAYSHRFRKPEGVFLDITEPDS 217
Query: 501 VYDVLKNWP-ETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPI 677
+ L + + DV IVV+D E ILG+GD G G+ I + KLAL T GGI P + LP+
Sbjct: 218 IECRLATYGGDKDVDYIVVSDSEGILGIGDQGIGGVRIAISKLALMTLCGGIHPGRVLPV 277
Query: 678 TIDVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDFG 848
+DVGTN + + D LY+G + R+RG YD+ ++F++AV + Y + ++ FEDFG
Sbjct: 278 CLDVGTNNKKLARDELYMGNKFSRIRGKQYDDFLEKFIKAVKKVY-PSAVLHFEDFG 333
>UniRef50_Q5K758 Cluster: Malic enzyme; n=1; Filobasidiella
neoformans|Rep: Malic enzyme - Cryptococcus neoformans
(Filobasidiella neoformans)
Length = 600
Score = 174 bits (423), Expect = 4e-42
Identities = 85/192 (44%), Positives = 119/192 (61%), Gaps = 3/192 (1%)
Frame = +3
Query: 279 KLSIDRYENPLNKYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYR 458
K + PL K+++L + + +LF+ + D + E+ PIVYTPTVG ACQK+ +Y
Sbjct: 95 KAHLQNLPTPLLKHVHLSKIRREDPNLFFSVMRDELTELAPIVYTPTVGEACQKYSQIYS 154
Query: 459 RPRGLFITIHDKGHVYDVLKNWPETDV---RAIVVTDGERILGLGDLGACGMGIPVGKLA 629
P GL++ I DK + ++L + V + +VVTDG RILGLGDLG GMGI VGKL
Sbjct: 155 GPEGLYLNIEDKDRIPEILHQYASKLVAPPQILVVTDGSRILGLGDLGIGGMGISVGKLN 214
Query: 630 LYTALGGIKPHQCLPITIDVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRR 809
LY A GG+ PH CLP+ +D+GTN +++ +DPLYIGL+Q RV + E D FM A
Sbjct: 215 LYVAGGGVNPHGCLPVVLDMGTNNEAVRNDPLYIGLKQPRVGLEEATEFMDAFMAAASEA 274
Query: 810 YGQNCLVXFEDF 845
+ ++ EDF
Sbjct: 275 F-PKAVIQHEDF 285
>UniRef50_P40375 Cluster: NAD-dependent malic enzyme; n=3;
Schizosaccharomyces pombe|Rep: NAD-dependent malic
enzyme - Schizosaccharomyces pombe (Fission yeast)
Length = 565
Score = 174 bits (423), Expect = 4e-42
Identities = 99/245 (40%), Positives = 142/245 (57%), Gaps = 7/245 (2%)
Frame = +3
Query: 141 LSGLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRY----ENP 308
L G+ L P NK AFT EERQ I LPP V+T ++QV+ C D+Y + P
Sbjct: 13 LKGVTLLNSPRYNKDTAFTPEERQKFEISSRLPPIVETLQQQVDRC---YDQYKAIGDEP 69
Query: 309 LNKYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITI- 485
L K +YL L N+ LFY ++ ++ EM+PI+YTPT G A ++F +YR P G ++ I
Sbjct: 70 LQKNLYLSQLSVTNQTLFYALISQHLIEMIPIIYTPTEGDAIKQFSDIYRYPEGCYLDID 129
Query: 486 -HDKGHVYDVLKNWPETD-VRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKP 659
+D ++ L + ++D V I++TD E ILG+GD G G+ I V K L T G+ P
Sbjct: 130 HNDLSYIKQQLSEFGKSDSVEYIIITDSEGILGIGDQGVGGVLISVAKGHLMTLCAGLDP 189
Query: 660 HQCLPITIDVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFE 839
++ LPI +DVGTN ++ + Y+GLR+ RVRG YD D ++A +R + FE
Sbjct: 190 NRFLPIVLDVGTNNETHRKNHQYMGLRKDRVRGEQYDSFLDNVIKA-IREVFPEAFIHFE 248
Query: 840 DFGNA 854
DFG A
Sbjct: 249 DFGLA 253
>UniRef50_A6XP71 Cluster: Malic enzyme protein 2; n=2;
Mucoromycotina|Rep: Malic enzyme protein 2 - Mortierella
alpina (Mortierella renispora)
Length = 669
Score = 173 bits (422), Expect = 6e-42
Identities = 96/249 (38%), Positives = 138/249 (55%), Gaps = 16/249 (6%)
Frame = +3
Query: 153 DHL----KHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKY 320
DHL +H G A E R L + GL P +V++ E Q + + + + KY
Sbjct: 95 DHLSNTHQHTDNMTGTATPTELRSALHLQGLTPAKVESFELQKKRALAQLRSKSSDIEKY 154
Query: 321 IYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYR------RPRGLFIT 482
++L L + N LFY V D + E +P++YTPTVG ACQ + +Y +P GLF++
Sbjct: 155 VFLAWLRNTNVRLFYGLVGDQLEETLPLIYTPTVGTACQNYSSIYPFLAPPGQPDGLFLS 214
Query: 483 IHDKGHVYDVLKNW------PETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTAL 644
I+D ++ +++N+ P + V+TDG RILGLGDLG GMGIPVGKL LY A
Sbjct: 215 INDLPNLTQIIQNYKPFPQDPSLTPQIAVITDGSRILGLGDLGVGGMGIPVGKLQLYVAG 274
Query: 645 GGIKPHQCLPITIDVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNC 824
GI P + LPIT+D+GTN + L D Y+GLR++R + D + A+ Y
Sbjct: 275 AGIDPRRTLPITLDLGTNNEDKLKDEFYLGLREKRAGDDKFFPFVDAVIEALTSLY-PKL 333
Query: 825 LVXFEDFGN 851
L+ FEDF +
Sbjct: 334 LIQFEDFSS 342
>UniRef50_Q48796 Cluster: Malolactic enzyme; n=49; Bacteria|Rep:
Malolactic enzyme - Oenococcus oeni (Leuconostoc oenos)
Length = 541
Score = 173 bits (420), Expect = 1e-41
Identities = 89/234 (38%), Positives = 135/234 (57%), Gaps = 2/234 (0%)
Frame = +3
Query: 159 LKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGL 338
L P +NKG AFT ER+ LG++GLLP +V+ +EQV+ + L K ++LM +
Sbjct: 8 LNDPFINKGTAFTEAEREELGLNGLLPAKVQALQEQVDQTYAQFQSKVSNLEKRLFLMEI 67
Query: 339 LDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGL-FITIHDKGHVYDVL 515
+ N LFY+ + +V E MPIVY PT+ + + ++ P+G F+ I+ ++ L
Sbjct: 68 FNTNHVLFYKLFSQHVVEFMPIVYDPTIADTIENYSELFVEPQGAAFLDINHPENIQSTL 127
Query: 516 KNWPE-TDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPITIDVG 692
KN D++ +VV+D E ILG+GD G G+ I VGKL +YT GI P L + ID G
Sbjct: 128 KNAANGRDIKLLVVSDAEGILGIGDWGVQGVDIAVGKLMVYTVAAGIDPSTVLAVVIDAG 187
Query: 693 TNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDFGNA 854
TN + +L DP+Y+G + RVRG Y + D+F+ + N + +EDFG +
Sbjct: 188 TNNEKLLKDPMYLGNKFNRVRGDKYYDFIDKFVNHAESLF-PNLYLHWEDFGRS 240
>UniRef50_Q5KBK5 Cluster: Nad-dependent malic enzyme, putative; n=2;
Filobasidiella neoformans|Rep: Nad-dependent malic
enzyme, putative - Cryptococcus neoformans
(Filobasidiella neoformans)
Length = 584
Score = 172 bits (419), Expect = 1e-41
Identities = 91/229 (39%), Positives = 134/229 (58%), Gaps = 1/229 (0%)
Frame = +3
Query: 159 LKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGL 338
L +P NKG AFT +ER + G LP V + E QV+ E + K +L +
Sbjct: 32 LNNPRFNKGSAFTHQERSEFALRGRLPYAVDSLEIQVKRAYEQYKSRETNILKNSFLQSM 91
Query: 339 LDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIH-DKGHVYDVL 515
+N LFY + ++ EM PIVYTPT A + ++RR GL++T +K D L
Sbjct: 92 KAQNWTLFYALLQAHLVEMFPIVYTPTEADAIADYSHLFRRSEGLYLTPPGEKNMEEDFL 151
Query: 516 KNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPITIDVGT 695
++ IVV+DGE ILG+GD G+ G+GI K +Y+ + G+ P +CL IT+DVGT
Sbjct: 152 DACEGRELELIVVSDGEAILGIGDQGSGGIGISGAKAVIYSLIAGVDPAKCLAITLDVGT 211
Query: 696 NTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFED 842
N Q +L+DPLYIG R++R+R YD+ D+F+ +V+++ CL+ FED
Sbjct: 212 NNQDLLNDPLYIGYREKRLRDDRYDQFVDKFV-GLVKKHQPECLLHFED 259
>UniRef50_A4SKB8 Cluster: NAD-dependent malic enzyme; n=2;
Aeromonas|Rep: NAD-dependent malic enzyme - Aeromonas
salmonicida (strain A449)
Length = 516
Score = 170 bits (413), Expect = 7e-41
Identities = 86/221 (38%), Positives = 134/221 (60%)
Frame = +3
Query: 183 GMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGLLDRNEHLF 362
G + ER+ G+ G +P + ++ +Q + ++P ++++ L L + N LF
Sbjct: 7 GTSLPYAERKRQGLMGRMPHKEESLAQQRRRIYRLVSAMQSPFDQHLLLRQLQEDNPVLF 66
Query: 363 YRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLKNWPETDVR 542
Y V ++ E++PI+YTP VG ACQ+ +Y R GL+++ HD+ + D + E +V
Sbjct: 67 YDLVRHHLPELLPIIYTPVVGEACQRHSDLYLRSHGLYLSWHDRDDL-DAIFAAVEQEVD 125
Query: 543 AIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPITIDVGTNTQSMLDDP 722
IV++DGER+LGLGDLG GMGI +GKLALY+A GGI P + LP+ +DVGTN +L+D
Sbjct: 126 VIVISDGERVLGLGDLGIGGMGICIGKLALYSAAGGINPARTLPLCVDVGTNNPELLEDD 185
Query: 723 LYIGLRQRRVRGPDYDELXDEFMRAVVRRYGQNCLVXFEDF 845
Y+G + RV G Y D+ + A+ R+ Q ++ FEDF
Sbjct: 186 SYLGWQANRVDGESYYHFMDKVVAAIRTRWPQ-VVLQFEDF 225
>UniRef50_Q5KEY3 Cluster: Malic enzyme; n=1; Filobasidiella
neoformans|Rep: Malic enzyme - Cryptococcus neoformans
(Filobasidiella neoformans)
Length = 629
Score = 169 bits (410), Expect = 2e-40
Identities = 93/256 (36%), Positives = 142/256 (55%), Gaps = 16/256 (6%)
Frame = +3
Query: 135 SGLSGLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLN 314
+ L G L P LNKG FT EERQ+ G+ G LP V + E+Q + + + +
Sbjct: 48 TNLRGSALLNTPRLNKGAGFTREERQIFGLEGFLPYDVHSLEKQCLRAYNQLCKQPSVIL 107
Query: 315 KYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDK 494
K+ +L L D+N+ LFYR + D + E++ ++YTP A + ++RRP G +I+ ++
Sbjct: 108 KHAFLASLRDQNQVLFYRLMQDRLKELLGVLYTPGAAEAVAGYSSLFRRPVGCYISFPNQ 167
Query: 495 --------GHVYDVLK--------NWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKL 626
GH+ DV + N P+ + +VVTD E ILG+GD G G+ I K
Sbjct: 168 DGMRAQLEGHLTDVNRTADVAYDSNKPDDAIDLVVVTDAEAILGIGDQGVGGITISTSKA 227
Query: 627 ALYTALGGIKPHQCLPITIDVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVR 806
ALYT GI P++ LP+ +D GT+ ++ DPLY+G ++ R+RG +YD+ D F+ R
Sbjct: 228 ALYTLGAGINPNRILPVVLDCGTDNHALFSDPLYMGWKRTRIRGKNYDQFIDRFI-TNCR 286
Query: 807 RYGQNCLVXFEDFGNA 854
N ++ FEDFG A
Sbjct: 287 ELFPNAIIHFEDFGMA 302
>UniRef50_A4RZU1 Cluster: Malic enzyme; n=2; Ostreococcus|Rep: Malic
enzyme - Ostreococcus lucimarinus CCE9901
Length = 539
Score = 157 bits (382), Expect = 4e-37
Identities = 94/214 (43%), Positives = 118/214 (55%), Gaps = 30/214 (14%)
Frame = +3
Query: 303 NPLNKYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFIT 482
+PL +Y+YL L + FYR + E+MP VYTPTVG AC+K+ + G++IT
Sbjct: 16 DPLERYVYLRELQRASAETFYRALVREPLELMPFVYTPTVGEACEKYHRLGIETNGVYIT 75
Query: 483 IHDKGHVYDVLK-NWPE---TDVRAIVVTDGE--------------------------RI 572
D G V L+ +W RA DGE RI
Sbjct: 76 ADDAGRVGAKLRGHWDRAAAARARAREGLDGEAAKRRGVDRRARADDGVAVAVVTDGERI 135
Query: 573 LGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPITIDVGTNTQSMLDDPLYIGLRQRRV 752
LGLGDLGA GMGI GK+ LYT G++P CLP+ +DVGTN Q +LDDP Y GLR+ R+
Sbjct: 136 LGLGDLGAGGMGISEGKILLYTVCAGVRPSACLPVCLDVGTNNQRLLDDPNYKGLRRTRL 195
Query: 753 RGPDYDELXDEFMRAVVRRYGQNCLVXFEDFGNA 854
+G YD L DEFMR +R + CLV FEDFGNA
Sbjct: 196 KGEAYDALVDEFMRE-MRAWQPRCLVQFEDFGNA 228
>UniRef50_A3YYQ0 Cluster: Malate oxidoreductase; n=1; Synechococcus
sp. WH 5701|Rep: Malate oxidoreductase - Synechococcus
sp. WH 5701
Length = 517
Score = 149 bits (360), Expect = 2e-34
Identities = 80/202 (39%), Positives = 119/202 (58%), Gaps = 1/202 (0%)
Frame = +3
Query: 246 VKTQEEQVELCKLSIDRYENPLNKYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVG 425
+++ E QVE + N L ++ + + L N LF+RF+AD++ +MPIVYTPTVG
Sbjct: 1 MESLETQVERHWQAFLSLRNDLERFRFAVALRQANLTLFHRFLADHIEAVMPIVYTPTVG 60
Query: 426 LACQKFGLVYRRPRG-LFITIHDKGHVYDVLKNWPETDVRAIVVTDGERILGLGDLGACG 602
A Q+F L YR P G +F+ D + VL V I++TD + ILG+GD G G
Sbjct: 61 AAIQRFSLDYRTPSGGVFLAAPDLERIESVLSQAATGPVDLILITDSQGILGIGDQGIGG 120
Query: 603 MGIPVGKLALYTALGGIKPHQCLPITIDVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXD 782
+ I +GKLA+YT G+ P + LP+ +DVGT+ +L++PLY G R R+ G DYD
Sbjct: 121 IEICLGKLAVYTLCAGLDPARVLPLVLDVGTDRVELLENPLYPGWRHPRLDGLDYDRFLA 180
Query: 783 EFMRAVVRRYGQNCLVXFEDFG 848
+ A+ R++ L+ +EDFG
Sbjct: 181 RSVEALQRQF-PGALLHWEDFG 201
>UniRef50_Q2HCG7 Cluster: Malic enzyme; n=1; Chaetomium
globosum|Rep: Malic enzyme - Chaetomium globosum (Soil
fungus)
Length = 586
Score = 145 bits (351), Expect = 2e-33
Identities = 88/234 (37%), Positives = 127/234 (54%), Gaps = 20/234 (8%)
Frame = +3
Query: 114 SGDGQPTSGLSGLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSID 293
S G L G L H NKG AFT EER+ + GLLP ++T ++QV+
Sbjct: 22 STSGPLECALKGTVLLNHSYFNKGSAFTKEERRDFELSGLLPQSIQTLDQQVQRAYEQYS 81
Query: 294 RYENPLNKYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGL 473
+ L K +L + ++NE L+++ M +VYTPT G A + F ++RRP+G+
Sbjct: 82 ARPDDLAKNTFLTSMKEQNEVLYFK--------MFSVVYTPTEGDAIENFSRLFRRPQGV 133
Query: 474 FITIHDKGHVYDVLKNW-PETDVRAIVVT-------------------DGERILGLGDLG 593
F+ +HD V+ L W D+ IVVT DGE ILG+GD G
Sbjct: 134 FLNVHDCDRVHHDLSLWGMPDDIDYIVVTGATFHPRARSRLRYQLTKLDGEEILGIGDQG 193
Query: 594 ACGMGIPVGKLALYTALGGIKPHQCLPITIDVGTNTQSMLDDPLYIGLRQRRVR 755
G+ I V KLAL T GI P++ LP+ +D GT+ +++L+DPLY+GLR++RVR
Sbjct: 194 CGGILISVAKLALMTLCAGIHPNRVLPVVLDCGTDNETLLNDPLYLGLREKRVR 247
>UniRef50_A5C6I9 Cluster: Malic enzyme; n=1; Vitis vinifera|Rep:
Malic enzyme - Vitis vinifera (Grape)
Length = 498
Score = 118 bits (283), Expect = 4e-25
Identities = 55/112 (49%), Positives = 74/112 (66%)
Frame = +3
Query: 477 ITIHDKGHVYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIK 656
IT + H++ + + V IV+TDG RILGLGDLG G+GIP+GKL +Y A GI
Sbjct: 21 ITXNGIXHIWSDIGSXDLCQVDMIVITDGSRILGLGDLGVQGIGIPIGKLDMYVAAAGIN 80
Query: 657 PHQCLPITIDVGTNTQSMLDDPLYIGLRQRRVRGPDYDELXDEFMRAVVRRY 812
P + LPI +DVGTN Q +L+D LY+GLRQ R+ G +Y + DE M A+ R+
Sbjct: 81 PQRILPIMLDVGTNNQRLLEDRLYLGLRQPRLEGEEYLSVVDELMEAIFTRW 132
>UniRef50_Q9S4T5 Cluster: NAD-malate oxidoreductase homolog; n=15;
Legionellales|Rep: NAD-malate oxidoreductase homolog -
Legionella pneumophila
Length = 117
Score = 89.8 bits (213), Expect = 1e-16
Identities = 45/99 (45%), Positives = 63/99 (63%)
Frame = +3
Query: 135 SGLSGLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLN 314
+ L G L P LNKG AFT EER+ G+ G LP RV+T +EQV+ L Y L
Sbjct: 19 TSLCGKPLLTTPQLNKGTAFTQEERKDFGLLGKLPHRVETLDEQVKRAYLQYSSYTTRLQ 78
Query: 315 KYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLA 431
++IYL L D+N+ +FY+ ++ ++ EM+PI+YTP VG A
Sbjct: 79 QHIYLNNLHDKNQIVFYKLLSRHLGEMLPIIYTPIVGAA 117
>UniRef50_Q8S484 Cluster: Putative NADP-dependent malic enzyme; n=1;
Zea mays|Rep: Putative NADP-dependent malic enzyme - Zea
mays (Maize)
Length = 309
Score = 60.9 bits (141), Expect = 7e-08
Identities = 36/82 (43%), Positives = 44/82 (53%)
Frame = +3
Query: 348 NEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLKNWP 527
+E LFY+ + DNV E++P VYT T G V DVLKNWP
Sbjct: 225 DERLFYKLLIDNVVELLPFVYTTT-------------------------GKVLDVLKNWP 259
Query: 528 ETDVRAIVVTDGERILGLGDLG 593
+++ I VTD ERILGLGDLG
Sbjct: 260 HRNIQVIFVTDSERILGLGDLG 281
>UniRef50_Q3W7J3 Cluster: Malate dehydrogenase; n=1; Frankia sp.
EAN1pec|Rep: Malate dehydrogenase - Frankia sp. EAN1pec
Length = 464
Score = 43.2 bits (97), Expect = 0.014
Identities = 24/58 (41%), Positives = 36/58 (62%), Gaps = 1/58 (1%)
Frame = +3
Query: 546 IVVTDGERILGLGDLG-ACGMGIPVGKLALYTALGGIKPHQCLPITIDVGTNTQSMLD 716
IVVTDG +LGLGD+G A + + GK AL+ GG+ +PI +D T+ + ++D
Sbjct: 142 IVVTDGTAVLGLGDIGPAAALPVMEGKAALFKHFGGV---DAVPICLDC-TDVEEIVD 195
>UniRef50_P54572 Cluster: Probable NAD-dependent malic enzyme 1;
n=4; Bacteria|Rep: Probable NAD-dependent malic enzyme 1
- Bacillus subtilis
Length = 439
Score = 41.9 bits (94), Expect = 0.033
Identities = 33/95 (34%), Positives = 47/95 (49%), Gaps = 1/95 (1%)
Frame = +3
Query: 405 VYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLKNWPETDVRAIVVTDGERILGLG 584
VYTP V C+ L+ + P +K +Y + N +VTDG ILGLG
Sbjct: 111 VYTPGVADVCR---LIEKEP--------EKASIYTTISN------SVAIVTDGTAILGLG 153
Query: 585 DLGA-CGMGIPVGKLALYTALGGIKPHQCLPITID 686
++G+ GM + GK AL+ L GI +PI +D
Sbjct: 154 NIGSVAGMPVMEGKAALFDQLAGISG---IPILLD 185
>UniRef50_Q8U225 Cluster: Malate oxidoreductase; n=41; cellular
organisms|Rep: Malate oxidoreductase - Pyrococcus
furiosus
Length = 435
Score = 41.5 bits (93), Expect = 0.043
Identities = 24/47 (51%), Positives = 28/47 (59%), Gaps = 1/47 (2%)
Frame = +3
Query: 549 VVTDGERILGLGDLGA-CGMGIPVGKLALYTALGGIKPHQCLPITID 686
VVTDG ILGLG++G GM + GK L+ AL GI PI ID
Sbjct: 77 VVTDGSAILGLGNIGVLAGMPVMEGKCVLFKALAGI---DAFPILID 120
>UniRef50_UPI0000DB7FF6 Cluster: PREDICTED: hypothetical protein,
partial; n=1; Apis mellifera|Rep: PREDICTED:
hypothetical protein, partial - Apis mellifera
Length = 95
Score = 40.3 bits (90), Expect = 0.099
Identities = 18/37 (48%), Positives = 25/37 (67%)
Frame = +3
Query: 72 TYXEMERDRIGLWGSGDGQPTSGLSGLDHLKHPGLNK 182
T ++RD++G G GD ++ L GLDHLK+P LNK
Sbjct: 59 TMSSVQRDQLGQRGHGDAMCSNLLRGLDHLKNPRLNK 95
>UniRef50_Q5Y0M3 Cluster: Malate oxidoreductase; n=8; cellular
organisms|Rep: Malate oxidoreductase - uncultured
archaeon GZfos12E1
Length = 444
Score = 39.9 bits (89), Expect = 0.13
Identities = 20/47 (42%), Positives = 29/47 (61%), Gaps = 1/47 (2%)
Frame = +3
Query: 549 VVTDGERILGLGDLGA-CGMGIPVGKLALYTALGGIKPHQCLPITID 686
+VTDG R+LGLGD+GA + + GK L+ LGG+ P+ +D
Sbjct: 84 IVTDGTRVLGLGDVGAEAALPVMEGKAMLFKYLGGV---DAFPLCLD 127
>UniRef50_Q2KKD0 Cluster: Oxalacetate decarboxylase; n=11;
Lactobacillales|Rep: Oxalacetate decarboxylase -
Enterococcus faecalis (Streptococcus faecalis)
Length = 390
Score = 39.1 bits (87), Expect = 0.23
Identities = 18/51 (35%), Positives = 29/51 (56%), Gaps = 1/51 (1%)
Frame = +3
Query: 504 YDVLKNWPETDVRAIVVTDGERILGLGDLGA-CGMGIPVGKLALYTALGGI 653
+++ + W + V+TDG +LGLG++G G+ I GK LY L G+
Sbjct: 49 HELAREWTISGKLIAVITDGSAVLGLGNMGTQAGLPIVEGKALLYKNLAGV 99
>UniRef50_A0DE35 Cluster: Malic enzyme; n=3; Paramecium
tetraurelia|Rep: Malic enzyme - Paramecium tetraurelia
Length = 687
Score = 39.1 bits (87), Expect = 0.23
Identities = 18/38 (47%), Positives = 27/38 (71%), Gaps = 1/38 (2%)
Frame = +3
Query: 543 AIVVTDGERILGLGDLG-ACGMGIPVGKLALYTALGGI 653
A ++T+G ILGLG++G + G+ + GK L+ ALGGI
Sbjct: 337 AAIITNGTAILGLGNIGPSAGLPVMEGKSVLFNALGGI 374
>UniRef50_Q4T5P0 Cluster: Malic enzyme; n=1; Tetraodon
nigroviridis|Rep: Malic enzyme - Tetraodon nigroviridis
(Green puffer)
Length = 306
Score = 37.5 bits (83), Expect = 0.70
Identities = 16/22 (72%), Positives = 18/22 (81%)
Frame = +2
Query: 857 AFRLLXKYRNKYXTFNDNIXGT 922
AFRLL KYR+ Y TFND+I GT
Sbjct: 18 AFRLLSKYRDMYCTFNDDIQGT 39
>UniRef50_Q8R7R6 Cluster: Malic enzyme; n=10; cellular
organisms|Rep: Malic enzyme - Thermoanaerobacter
tengcongensis
Length = 394
Score = 36.7 bits (81), Expect = 1.2
Identities = 23/73 (31%), Positives = 36/73 (49%), Gaps = 2/73 (2%)
Frame = +3
Query: 549 VVTDGERILGLGDLGA-CGMGIPVGKLALYTALGGIKPHQCLPITIDVGTNTQSMLD-DP 722
VVTDG +LGLG++G + + GK L+ GGI T DV +++L+ P
Sbjct: 66 VVTDGSAVLGLGNIGPYAALPVMEGKAVLFKEFGGIDAIPICLATQDVDEIIRTVLNIAP 125
Query: 723 LYIGLRQRRVRGP 761
+ G+ + P
Sbjct: 126 TFGGINLEDISAP 138
>UniRef50_Q9HKY7 Cluster: Malate oxidoreductase (Malic enzyme)
related protein; n=17; Archaea|Rep: Malate
oxidoreductase (Malic enzyme) related protein -
Thermoplasma acidophilum
Length = 467
Score = 36.7 bits (81), Expect = 1.2
Identities = 19/48 (39%), Positives = 29/48 (60%), Gaps = 1/48 (2%)
Frame = +3
Query: 549 VVTDGERILGLGDLG-ACGMGIPVGKLALYTALGGIKPHQCLPITIDV 689
++TDG R+LGLG++G M + GK ++ LGG+ +PI I V
Sbjct: 94 ILTDGTRVLGLGNIGPEAAMPVMEGKALIFNYLGGV---NAIPIPIRV 138
>UniRef50_Q0STR8 Cluster: Malate oxidoreductase; n=2; Clostridium
perfringens|Rep: Malate oxidoreductase - Clostridium
perfringens (strain SM101 / Type A)
Length = 381
Score = 36.3 bits (80), Expect = 1.6
Identities = 27/106 (25%), Positives = 46/106 (43%), Gaps = 5/106 (4%)
Frame = +3
Query: 498 HVYDVLKNWPETDVRAIVVTDGERILGLGDLGA-CGMGIPVGKLALYTALGGIKPHQCLP 674
H +LK V+TDG +LGLG++G G I K +Y L G+ +P
Sbjct: 48 HHPSMLKTLTSVGNSIAVITDGTAVLGLGNIGTLAGYPIVEAKALVYKDLAGV---NAIP 104
Query: 675 ITID-VGTNTQSMLDDPLY---IGLRQRRVRGPDYDELXDEFMRAV 800
+ +D +G N +Y G+ ++ P+ + DE + +
Sbjct: 105 LCVDQIGCNELIKTIKNIYSSFSGIHLEDIKAPECFYIEDELKKTL 150
>UniRef50_Q4PDI7 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 1653
Score = 34.7 bits (76), Expect = 4.9
Identities = 35/117 (29%), Positives = 50/117 (42%), Gaps = 13/117 (11%)
Frame = +1
Query: 397 CQLCTLRRLAWPVRSSGLCTA--DQGASSSRSTIRDMYTMFLRTGRRRTSVPLL*PTENV 570
C R+ PV + +A D ++ S+ D T F +GRRR S PLL P +
Sbjct: 93 CSTSANTRVCQPVAPPRVPSASLDHNKDATSSSTSDRQTEF-SSGRRRPSPPLLVPPKQT 151
Query: 571 FW---------VWATWAHAGW--ASQWANSRSTPRSEASSRISVCPSLSTWVRTPSR 708
F WA H + A+ A+ ++P S ASS + PS S +V R
Sbjct: 152 FRKVPSNRVLPAWALSDHQKFMAAANKASQPASPSSTASSEAASSPSRSPFVNAALR 208
>UniRef50_Q2STW7 Cluster: Putative uncharacterized protein; n=1;
Burkholderia thailandensis E264|Rep: Putative
uncharacterized protein - Burkholderia thailandensis
(strain E264 / ATCC 700388 / DSM 13276 /CIP 106301)
Length = 647
Score = 34.3 bits (75), Expect = 6.5
Identities = 17/43 (39%), Positives = 22/43 (51%)
Frame = +3
Query: 507 DVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALY 635
DVL+ +P T V DG + GLG+L CG P +L Y
Sbjct: 97 DVLRQFPHTYVERSPSGDGLHLFGLGELVECGKAGPGNRLECY 139
>UniRef50_Q116W6 Cluster: Putative uncharacterized protein; n=1;
Trichodesmium erythraeum IMS101|Rep: Putative
uncharacterized protein - Trichodesmium erythraeum
(strain IMS101)
Length = 1107
Score = 34.3 bits (75), Expect = 6.5
Identities = 27/88 (30%), Positives = 42/88 (47%), Gaps = 2/88 (2%)
Frame = +3
Query: 111 GSGDGQPTSGLSGLDHLKHPGL-NKGMAFTIEERQLLGIHGL-LPPRVKTQEEQVELCKL 284
GSG G +G + GL G++ E LLGI + LP ++K E + + +L
Sbjct: 609 GSGFGALGLKFTGCKIVDGFGLITLGISQNEFEINLLGIATMMLPTKLKDNYEPIAMAEL 668
Query: 285 SIDRYENPLNKYIYLMGLLDRNEHLFYR 368
+I NP+ I + G L N ++F R
Sbjct: 669 AIAGRFNPMEGVILIQGQLTENSYIFSR 696
>UniRef50_Q08PM3 Cluster: Hemin ABC transporter, periplasmic
hemin-binding protein; n=1; Stigmatella aurantiaca
DW4/3-1|Rep: Hemin ABC transporter, periplasmic
hemin-binding protein - Stigmatella aurantiaca DW4/3-1
Length = 332
Score = 34.3 bits (75), Expect = 6.5
Identities = 32/104 (30%), Positives = 44/104 (42%)
Frame = +3
Query: 252 TQEEQVELCKLSIDRYENPLNKYIYLMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLA 431
T EQ+ KL + EN + I GLL R E L F A+ + M T V
Sbjct: 143 TSAEQLRGAKLPVLILENSSKEGI--SGLLRRIEVLARVFNAEEAGQRMKQDITRQVAEL 200
Query: 432 CQKFGLVYRRPRGLFITIHDKGHVYDVLKNWPETDVRAIVVTDG 563
+K L ++PR LF+ H G + K ET A++ G
Sbjct: 201 EKKIALAKKKPRVLFLYAHSPGEAFVYGK---ETGTHALIELAG 241
>UniRef50_A1CKF3 Cluster: Stress response protein (Ish1), putative;
n=5; Pezizomycotina|Rep: Stress response protein (Ish1),
putative - Aspergillus clavatus
Length = 516
Score = 34.3 bits (75), Expect = 6.5
Identities = 24/64 (37%), Positives = 30/64 (46%), Gaps = 9/64 (14%)
Frame = -2
Query: 473 EAPW-SAVHKPELLTGQANRRSVHNWHHFSHVIRDETVEQML--------IAVQEPHKID 321
+A W S V KP GQA + HNWHH I D + L + V +P K D
Sbjct: 63 KANWDSKVQKP---LGQAAEHTTHNWHHAKEWIFDTWSDSQLKAFLDRHGVPVPQPRKRD 119
Query: 320 VLVK 309
VL+K
Sbjct: 120 VLLK 123
>UniRef50_Q4SHK3 Cluster: Chromosome 5 SCAF14581, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 5 SCAF14581, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 72
Score = 33.9 bits (74), Expect = 8.6
Identities = 19/50 (38%), Positives = 24/50 (48%)
Frame = -3
Query: 280 LHSSTCSSCVLTRGGNNPCMPKS*RSSMVKAMPLLRPGCLRWSRPERPLV 131
L S SS +RG P P SS ++ R G RWSRP RP++
Sbjct: 22 LKGSAASSAAASRGQKTPASPTVPGSSQLQT----RSGQARWSRPRRPML 67
>UniRef50_Q5SLE4 Cluster: CBS domain protein; n=7; Bacteria|Rep: CBS
domain protein - Thermus thermophilus (strain HB8 / ATCC
27634 / DSM 579)
Length = 143
Score = 33.9 bits (74), Expect = 8.6
Identities = 14/33 (42%), Positives = 22/33 (66%)
Frame = +3
Query: 483 IHDKGHVYDVLKNWPETDVRAIVVTDGERILGL 581
IH + V D L+ E D+ A++V +GER+LG+
Sbjct: 17 IHPEATVLDALRKLAEHDIGALLVMEGERLLGI 49
>UniRef50_Q5C370 Cluster: Malic enzyme; n=1; Schistosoma
japonicum|Rep: Malic enzyme - Schistosoma japonicum
(Blood fluke)
Length = 264
Score = 33.9 bits (74), Expect = 8.6
Identities = 14/27 (51%), Positives = 19/27 (70%)
Frame = +2
Query: 842 LRERXAFRLLXKYRNKYXTFNDNIXGT 922
L+ AF+LL +YR Y TFND+I G+
Sbjct: 32 LKNSNAFQLLERYRPNYITFNDDIQGS 58
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 954,133,413
Number of Sequences: 1657284
Number of extensions: 20795357
Number of successful extensions: 64607
Number of sequences better than 10.0: 79
Number of HSP's better than 10.0 without gapping: 60836
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 64528
length of database: 575,637,011
effective HSP length: 103
effective length of database: 404,936,759
effective search space used: 123910648254
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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