Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fdpeP18_F_F03
(1320 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q9VK80 Cluster: CG17024-PA; n=1; Drosophila melanogaste... 368 e-100
UniRef50_P22234 Cluster: Multifunctional protein ADE2 [Includes:... 342 1e-92
UniRef50_UPI0000F33553 Cluster: phosphoribosylaminoimidazole car... 322 2e-86
UniRef50_A5UWC5 Cluster: Phosphoribosylaminoimidazolesuccinocarb... 227 4e-58
UniRef50_Q6NRP1 Cluster: LOC431975 protein; n=2; Xenopus|Rep: LO... 194 3e-48
UniRef50_Q5FIU8 Cluster: Phosphoribosylaminoimidazole-succinocar... 137 5e-31
UniRef50_Q4J8G0 Cluster: Phosphoribosylaminoimidazole-succinocar... 133 8e-30
UniRef50_Q49WJ0 Cluster: Phosphoribosylaminoimidazole-succinocar... 130 1e-28
UniRef50_P12046 Cluster: Phosphoribosylaminoimidazole-succinocar... 126 1e-27
UniRef50_Q8TX83 Cluster: Phosphoribosylaminoimidazole-succinocar... 125 2e-27
UniRef50_Q7M9X5 Cluster: Phosphoribosylaminoimidazole-succinocar... 124 4e-27
UniRef50_O57978 Cluster: Phosphoribosylaminoimidazole-succinocar... 124 4e-27
UniRef50_Q58987 Cluster: Phosphoribosylaminoimidazole-succinocar... 124 7e-27
UniRef50_Q92AN6 Cluster: Phosphoribosylaminoimidazole-succinocar... 123 9e-27
UniRef50_UPI00015BB105 Cluster: phosphoribosylaminoimidazole-suc... 122 2e-26
UniRef50_Q87Y59 Cluster: Phosphoribosylaminoimidazole-succinocar... 122 2e-26
UniRef50_Q8ES99 Cluster: Phosphoribosylaminoimidazole-succinocar... 122 2e-26
UniRef50_Q8G5A9 Cluster: Phosphoribosylaminoimidazole-succinocar... 120 8e-26
UniRef50_A6QAA3 Cluster: Phosphoribosylaminoimidazole-succinocar... 119 1e-25
UniRef50_Q7V5X1 Cluster: Phosphoribosylaminoimidazole-succinocar... 118 3e-25
UniRef50_P0A7E0 Cluster: Phosphoribosylaminoimidazole-succinocar... 112 2e-23
UniRef50_A3H6Y2 Cluster: Phosphoribosylaminoimidazole-succinocar... 111 4e-23
UniRef50_P73471 Cluster: Phosphoribosylaminoimidazole-succinocar... 109 1e-22
UniRef50_Q9X0X0 Cluster: Phosphoribosylaminoimidazole-succinocar... 109 2e-22
UniRef50_Q8ZCD2 Cluster: Phosphoribosylaminoimidazole-succinocar... 108 3e-22
UniRef50_Q8TIS9 Cluster: Phosphoribosylaminoimidazole-succinocar... 107 6e-22
UniRef50_Q7VAN8 Cluster: Phosphoribosylaminoimidazole-succinocar... 105 3e-21
UniRef50_A4M8A0 Cluster: Phosphoribosylaminoimidazole-succinocar... 103 1e-20
UniRef50_Q3YRB0 Cluster: SAICAR synthetase; n=2; Anaplasmataceae... 103 1e-20
UniRef50_Q9RXT0 Cluster: Phosphoribosylaminoimidazole-succinocar... 101 6e-20
UniRef50_Q8ZZK5 Cluster: Phosphoribosylaminoimidazole-succinocar... 99 1e-19
UniRef50_Q6LZT3 Cluster: Phosphoribosylaminoimidazole-succinocar... 97 1e-18
UniRef50_Q03Y92 Cluster: Phosphoribosylaminoimidazolesuccinocarb... 93 1e-17
UniRef50_Q98NM8 Cluster: Phosphoribosylaminoimidazole-succinocar... 93 1e-17
UniRef50_Q88U22 Cluster: Phosphoribosylaminoimidazole-succinocar... 91 4e-17
UniRef50_Q5JD27 Cluster: Phosphoribosylaminoimidazolesuccinocarb... 78 4e-13
UniRef50_Q466M0 Cluster: Phosphoribosylaminoimidazole carboxylas... 74 1e-11
UniRef50_Q648Z8 Cluster: Phosphoribosylaminoimidazolesuccinocarb... 71 9e-11
UniRef50_Q0AXN6 Cluster: Phosphoribosylaminoimidazolesuccinocarb... 69 2e-10
UniRef50_A7DSW8 Cluster: Phosphoribosylaminoimidazolesuccinocarb... 68 6e-10
UniRef50_A0RW02 Cluster: Phosphoribosylaminoimidazole-succinocar... 63 1e-08
UniRef50_Q4UML8 Cluster: Phosphoribosylaminoimidazole-succinocar... 62 4e-08
UniRef50_P38025 Cluster: Phosphoribosylaminoimidazole-succinocar... 59 2e-07
UniRef50_A5CCM2 Cluster: Phosphoribosylaminoimidazole-succinocar... 58 7e-07
UniRef50_Q895U7 Cluster: Phosphoribosylaminoimidazole-succinocar... 57 9e-07
UniRef50_A6BCY4 Cluster: Phosphoribosylaminoimidazole-succinocar... 57 1e-06
UniRef50_Q73PW0 Cluster: Phosphoribosylaminoimidazole-succinocar... 56 2e-06
UniRef50_Q8F0I0 Cluster: Phosphoribosylaminoimidazole-succinocar... 56 2e-06
UniRef50_A4SAQ9 Cluster: Phosphoribosylaminoimidazole-succinocar... 55 4e-06
UniRef50_A7BA15 Cluster: Putative uncharacterized protein; n=1; ... 53 2e-05
UniRef50_Q3WE59 Cluster: SAICAR synthetase; n=5; Bacteria|Rep: S... 50 2e-04
UniRef50_P43060 Cluster: Phosphoribosylaminoimidazole-succinocar... 49 2e-04
UniRef50_Q1IPE1 Cluster: Phosphoribosylaminoimidazole-succinocar... 49 3e-04
UniRef50_Q7MVR8 Cluster: Phosphoribosylaminoimidazole-succinocar... 48 5e-04
UniRef50_A1G3E0 Cluster: SAICAR synthetase; n=1; Salinispora are... 46 0.002
UniRef50_Q3ET89 Cluster: Phosphoribosylamidoimidazole-succinocar... 46 0.003
UniRef50_Q1MRH1 Cluster: Phosphoribosylaminoimidazolesuccinocarb... 44 0.007
UniRef50_Q7UJ19 Cluster: Phosphoribosylaminoimidazole-succinocar... 43 0.015
UniRef50_Q98I23 Cluster: Putative phosphoribosylaminoimidazole-s... 43 0.015
UniRef50_A7H9G3 Cluster: Phosphoribosylaminoimidazolesuccinocarb... 43 0.020
UniRef50_A0Q508 Cluster: Phosphoribosylaminoimidazole-succinocar... 43 0.020
UniRef50_Q5IWX2 Cluster: Plastid phosphoribosylaminoimidazole-su... 42 0.036
UniRef50_Q9C1J4 Cluster: Phosphoribosylaminoimidazole-succinocar... 42 0.036
UniRef50_A7CZ13 Cluster: Phosphoribosylaminoimidazolesuccinocarb... 42 0.047
UniRef50_Q8A004 Cluster: Phosphoribosylaminoimidazole-succinocar... 40 0.11
UniRef50_Q67KF6 Cluster: Phosphoribosylaminoimidazole-succinocar... 37 1.0
UniRef50_P27616 Cluster: Phosphoribosylaminoimidazole-succinocar... 37 1.3
UniRef50_Q94IQ2 Cluster: Phosphoribosylaminoimidazole-succinocar... 36 1.8
UniRef50_Q60136 Cluster: Penicillin G acylase precursor (EC 3.5.... 36 2.3
UniRef50_Q3Z881 Cluster: Phosphoribosylaminoimidazole-succinocar... 36 3.1
UniRef50_Q9HLC0 Cluster: Phosphoribosylaminoimidazole-succinocar... 35 4.1
UniRef50_A7TI33 Cluster: Putative uncharacterized protein; n=1; ... 35 5.4
UniRef50_Q9HYC1 Cluster: Putative uncharacterized protein; n=2; ... 34 9.5
UniRef50_P46970 Cluster: Nonsense-mediated mRNA decay protein 5;... 34 9.5
>UniRef50_Q9VK80 Cluster: CG17024-PA; n=1; Drosophila
melanogaster|Rep: CG17024-PA - Drosophila melanogaster
(Fruit fly)
Length = 395
Score = 368 bits (906), Expect = e-100
Identities = 160/265 (60%), Positives = 210/265 (79%)
Frame = +1
Query: 130 VGQYKLGKLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAK 309
+G Y+LGK+LIEGKTK+V+D+PD PG CLLL+KDRITA DG+ AH+L+GKAAISN TN
Sbjct: 6 IGGYQLGKILIEGKTKKVYDLPDHPGLCLLLSKDRITAFDGLMAHELQGKAAISNTTNGL 65
Query: 310 VFEILKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTP 489
VF +L AGI+TA+V + AF+++KC+M+ IEWVTRRLATGSF+K NP VPEG+RF P
Sbjct: 66 VFRLLNEAGIRTAYVDQCGDNAFIARKCQMVHIEWVTRRLATGSFIKLNPEVPEGYRFAP 125
Query: 490 PKQETFFKDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALR 669
PKQET FKDD++HDP W +EQI+S+ F NGL+IG DEV MR+ ++++FE+LE+AW +
Sbjct: 126 PKQETCFKDDSSHDPLWCDEQILSSNFECNGLIIGADEVQIMRRTSLVVFEVLERAWKTK 185
Query: 670 DCALIDMKIEFGVDTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYRNXXXXXXXXXXX 849
+CAL+DMK+EFGVD +G+I+LAD+IDSD+WR+WP+GDKRLMVDK VY N
Sbjct: 186 NCALVDMKVEFGVDEDGNILLADIIDSDTWRIWPAGDKRLMVDKTVYINLDTVTDSDLNT 245
Query: 850 XKRNFAWVKDQLDFLKPTIXHKVVV 924
KRN++WV +QL + P H VV+
Sbjct: 246 VKRNYSWVIEQLSSIAPPQDHLVVI 270
>UniRef50_P22234 Cluster: Multifunctional protein ADE2 [Includes:
Phosphoribosylaminoimidazole- succinocarboxamide
synthase (EC 6.3.2.6) (SAICAR synthetase);
Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21)
(AIR carboxylase) (AIRC)]; n=60; Eumetazoa|Rep:
Multifunctional protein ADE2 [Includes:
Phosphoribosylaminoimidazole- succinocarboxamide
synthase (EC 6.3.2.6) (SAICAR synthetase);
Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21)
(AIR carboxylase) (AIRC)] - Homo sapiens (Human)
Length = 425
Score = 342 bits (840), Expect = 1e-92
Identities = 165/282 (58%), Positives = 207/282 (73%), Gaps = 2/282 (0%)
Frame = +1
Query: 145 LGKLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEIL 324
+GK L EGKTK+V+++ D PG LL +KD+ITAG+ + + LEGKAAISN+ + +F++L
Sbjct: 9 IGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLL 68
Query: 325 KSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQET 504
+ AGIKTAF + ETAF++ +CEMIPIEWV RR+ATGSFLKRNPGV EG++F PPK E
Sbjct: 69 QEAGIKTAFTRKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVEL 128
Query: 505 FFKDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALI 684
FFKDDAN+DPQWSEEQ+I+AKF + GLLIG+ EVD M AT IFEILEK+W ++C L+
Sbjct: 129 FFKDDANNDPQWSEEQLIAAKFCFAGLLIGQTEVDIMSHATQAIFEILEKSWLPQNCTLV 188
Query: 685 DMKIEFGVD-TEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYRNXXXXXXXXXXXXKRN 861
DMKIEFGVD T IVLADVID+DSWRLWPSGD+ DKQ YR+ K+N
Sbjct: 189 DMKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKN 248
Query: 862 FAWVKDQLD-FLKPTIXHKVVVFMGSXADQXHCXKIXKLPXN 984
F WV ++++ LK +VVV MGS +D HC KI K N
Sbjct: 249 FEWVAERVELLLKSESQCRVVVLMGSTSDLGHCEKIKKACGN 290
>UniRef50_UPI0000F33553 Cluster: phosphoribosylaminoimidazole
carboxylase, phosphoribosylaminoimidazole
succinocarboxamide synthetase; n=2; Coelomata|Rep:
phosphoribosylaminoimidazole carboxylase,
phosphoribosylaminoimidazole succinocarboxamide
synthetase - Bos Taurus
Length = 402
Score = 322 bits (790), Expect = 2e-86
Identities = 151/252 (59%), Positives = 190/252 (75%), Gaps = 1/252 (0%)
Frame = +1
Query: 142 KLGKLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEI 321
K+GK L EGKTK+V+++ D PG LL +KD+ITAG+ + + LEGKAAISN+ + +F++
Sbjct: 11 KIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQL 70
Query: 322 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 501
L+ AGIKTAF K ETAF++ KCEMIPIEWV RR+ATGSFLKRNPGV EG++F PPK E
Sbjct: 71 LQEAGIKTAFTKKCGETAFIAPKCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVE 130
Query: 502 TFFKDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCAL 681
FFKDDAN+DPQWSEEQ+I+A F + GL+IG+ EVD M AT IFEILEK+W ++C L
Sbjct: 131 MFFKDDANNDPQWSEEQLIAANFCFAGLVIGQTEVDIMSHATQAIFEILEKSWLPQNCTL 190
Query: 682 IDMKIEFGVDT-EGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYRNXXXXXXXXXXXXKR 858
+DMKIEFGVD IVLADVID+DSWRLWPSGD+ DKQ YR+ K+
Sbjct: 191 VDMKIEFGVDVITREIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKK 250
Query: 859 NFAWVKDQLDFL 894
NF WV ++++ L
Sbjct: 251 NFEWVAERVEVL 262
>UniRef50_A5UWC5 Cluster:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase;
n=5; Chloroflexi (class)|Rep:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase
- Roseiflexus sp. RS-1
Length = 249
Score = 227 bits (556), Expect = 4e-58
Identities = 108/224 (48%), Positives = 148/224 (66%)
Frame = +1
Query: 145 LGKLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEIL 324
LG+ L EGKTK V+ P P ++++KD I+AGDG + H + GK A+S +T A VF +L
Sbjct: 3 LGEKLAEGKTKIVYAHPTDPTLAIIVHKDGISAGDGARRHTIPGKGALSGRTTANVFTML 62
Query: 325 KSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQET 504
AG+ T FV + + +C MIP+E V RR+ATGS+++RNP V EG RF PP E
Sbjct: 63 NRAGVATHFVAAPEPSVMVVYRCAMIPLEVVNRRIATGSYIRRNPDVAEGTRFDPPLLEF 122
Query: 505 FFKDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALI 684
F KDDA HDPQ + ++II+ + DEV+ M + +F ++E+AWA +D L
Sbjct: 123 FLKDDARHDPQMTPDEIIAQG------IASADEVEQMASESRRVFLLIEEAWAAQDVVLC 176
Query: 685 DMKIEFGVDTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYRN 816
D+KIEFG DT G +++ADVID+DSWR+WP G K M+DKQVYRN
Sbjct: 177 DLKIEFGRDTSGRLLVADVIDNDSWRIWPGGVKERMLDKQVYRN 220
>UniRef50_Q6NRP1 Cluster: LOC431975 protein; n=2; Xenopus|Rep:
LOC431975 protein - Xenopus laevis (African clawed frog)
Length = 371
Score = 194 bits (474), Expect = 3e-48
Identities = 107/237 (45%), Positives = 154/237 (64%), Gaps = 3/237 (1%)
Frame = +1
Query: 82 IPTWRSKIAKMSHPKQ-VGQYKLGKLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVK 258
IP +++ + ++ V + KLGK L E + +V+++ +QPG L+ +KD I A
Sbjct: 62 IPLYKTLVQHCPDEREHVTELKLGKKLREDEATEVYELSEQPGCVLIQSKDHINAQYTAW 121
Query: 259 AHDLEGKAAISNQTNAKVFEILKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATG 438
+ KA++SN+ ++VF +L+ AGIKTAFVK SE AF++ +CEMIPIEW R++ TG
Sbjct: 122 DGHKDTKASVSNKATSRVFILLQEAGIKTAFVKRCSEAAFIATQCEMIPIEWFCRKIPTG 181
Query: 439 SFLKRNPGVPEGFRFTPPKQETFFKDD-ANHDPQWSEEQIISAKFNYNGLLIGRDEVDYM 615
RN EG+RF+ PK E + DD +NH Q S+EQ+++ K GLLIG+ EVD M
Sbjct: 182 ----RNTETDEGYRFSQPKVEMYKVDDTSNH--QLSKEQLMAVKLICAGLLIGKMEVDVM 235
Query: 616 RKATILIFEILEKAWALRDCALIDMKIEFGVD-TEGSIVLADVIDSDSWRLWPSGDK 783
++TI IFEI+EKAW +DC L+DM+I+FGVD T+ I+L D I S LWP G+K
Sbjct: 236 TRSTIAIFEIIEKAWRAQDCTLVDMRIKFGVDVTKKEILLTD-IKCGSQALWPLGNK 291
>UniRef50_Q5FIU8 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamidesynthase;
n=6; Lactobacillus|Rep:
Phosphoribosylaminoimidazole-succinocarboxamidesynthase
- Lactobacillus acidophilus
Length = 238
Score = 137 bits (332), Expect = 5e-31
Identities = 83/223 (37%), Positives = 120/223 (53%)
Frame = +1
Query: 145 LGKLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEIL 324
+ KLL GK K+++ D P ++ D+ TAG+G K D + KA ++N+ + +FE L
Sbjct: 1 MAKLLYTGKVKEMWST-DDPEVLRVVYTDQATAGNGEKKDDFKNKAYLNNEISTLIFEYL 59
Query: 325 KSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQET 504
GI T F+K S+T L KKCEM P+E VTR +A G F R G+ EG +F P +E
Sbjct: 60 AKNGIPTHFIKKISDTEELVKKCEMFPLEVVTRNIAAGHFSSRY-GMGEGEKFDTPVEEL 118
Query: 505 FFKDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALI 684
F+K D DP +E I+ + + + R+ L+ + +KA L+
Sbjct: 119 FYKSDELDDPIMNESDAIA--LHIATAEEQKKIWELSRQVNKLLIPLFDKA----GMELV 172
Query: 685 DMKIEFGVDTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYR 813
D K+EFG D +G+I+LAD D+ RLW K M DK VYR
Sbjct: 173 DFKLEFGKDADGNIILADEFSPDNCRLWDKKTKEHM-DKDVYR 214
>UniRef50_Q4J8G0 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=4; Sulfolobaceae|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Sulfolobus acidocaldarius
Length = 235
Score = 133 bits (322), Expect = 8e-30
Identities = 79/221 (35%), Positives = 122/221 (55%)
Frame = +1
Query: 151 KLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKS 330
K + EGKTK V++ P + LL KD ITAGDG + +L GK ++ QT+A F +L+
Sbjct: 4 KRVAEGKTKIVYEF--DPEHYLLRFKDSITAGDGARKDELPGKGTLNAQTSALFFRLLEK 61
Query: 331 AGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETFF 510
I+T +V + E + K +MIP+E V R +ATGS +KR P + EG F PP E F
Sbjct: 62 NDIRTHYVGMYDEKTMIVTKLKMIPVEVVLRNIATGSIVKRLP-IKEGEVFDPPIVEFFL 120
Query: 511 KDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDM 690
KDD HDP + + FN L+ R E + + + + + +++ R L D+
Sbjct: 121 KDDLRHDPLLNYSHL--QYFN----LLTRKEAEIVEEVIVKVNAVMKNFLKERGLVLYDL 174
Query: 691 KIEFGVDTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYR 813
K+EFG D + ++++ D I DS R+ +++ DK +YR
Sbjct: 175 KLEFGKDKDNNLIVGDEITLDSMRVRDEKTNKIL-DKDLYR 214
>UniRef50_Q49WJ0 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=1; Staphylococcus saprophyticus subsp.
saprophyticus ATCC 15305|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Staphylococcus saprophyticus subsp. saprophyticus
(strain ATCC 15305 /DSM 20229)
Length = 233
Score = 130 bits (313), Expect = 1e-28
Identities = 79/220 (35%), Positives = 117/220 (53%)
Frame = +1
Query: 154 LLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKSA 333
LL EGK K++F + KD +TAG+G K +EGK ++NQ +++F LK+
Sbjct: 3 LLYEGKAKRIFSTGTSD-VLRVEYKDEVTAGNGAKKDFIEGKGRLNNQITSRIFNYLKAK 61
Query: 334 GIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETFFK 513
G+ + F++ SET L E+IP+E V R +A GS KR G +G F P E F+K
Sbjct: 62 GLNSHFIEQISETEQLVNSVEIIPLEVVVRNIAAGSITKR-LGFEKGHTFETPLVEFFYK 120
Query: 514 DDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMK 693
+D +DP +E+ I + +G E++ +++A I E+L + L+D K
Sbjct: 121 NDDLNDPLITEDHIKLLQIANDG------EIEKLKEAATEINEVLVNLMDKMNLRLVDFK 174
Query: 694 IEFGVDTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYR 813
IEFG EG I+LAD I D+ R+W DK VYR
Sbjct: 175 IEFGRTNEGEILLADEISPDTCRIWDK-QSDTNFDKDVYR 213
>UniRef50_P12046 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=61; Bacilli|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Bacillus subtilis
Length = 241
Score = 126 bits (305), Expect = 1e-27
Identities = 75/221 (33%), Positives = 122/221 (55%)
Frame = +1
Query: 151 KLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKS 330
+LL EGK K+++ D+ ++ KD TA +G K ++ GK ++N+ ++ +F+ L +
Sbjct: 7 ELLYEGKAKKIYKTDDE-NTLYVVYKDSATAFNGEKKAEISGKGRLNNEISSLIFKHLHA 65
Query: 331 AGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETFF 510
GI F++ SET L KK ++P+E V R + GS KR G+PEG P E ++
Sbjct: 66 KGINNHFIERISETEQLIKKVTIVPLEVVVRNVVAGSMSKR-LGIPEGTELEQPIIEFYY 124
Query: 511 KDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDM 690
KDDA DP +E+ I K ++V+ ++ T ++ E L+ + LID
Sbjct: 125 KDDALGDPLITEDHIWLLK------AATPEQVETIKSITTIVNEELQSIFDDCHVRLIDF 178
Query: 691 KIEFGVDTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYR 813
K+EFG+D EG ++LAD I D+ RLW + +DK ++R
Sbjct: 179 KLEFGLDAEGQVLLADEISPDTCRLWDK-ETNEKLDKDLFR 218
>UniRef50_Q8TX83 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=6; cellular organisms|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Methanopyrus kandleri
Length = 247
Score = 125 bits (302), Expect = 2e-27
Identities = 71/222 (31%), Positives = 123/222 (55%)
Frame = +1
Query: 148 GKLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILK 327
G+L+ EGK K +++ P+ ++ +D ITA + K +EGK + +A++FE+L+
Sbjct: 4 GRLVYEGKAKSLYEHPEDENLLVMEFRDDITAFNMEKMDTVEGKGVYNCLISARLFEVLE 63
Query: 328 SAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETF 507
AGI T +V++A E + ++ +M +E + R +ATGS ++R P EG + PP E
Sbjct: 64 DAGIPTHYVELADERRMVVERLDMFNLEVICRNMATGSLVERLP-FEEGEKLDPPIVEFD 122
Query: 508 FKDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALID 687
+K D DP + + I + L +EV+ MR+ T+ + E+L + D L+D
Sbjct: 123 YKSDEYGDPMVNMDHIRALG------LATEEEVERMRELTLQVNEVLSEFLKDCDIILVD 176
Query: 688 MKIEFGVDTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYR 813
K+EFGV+ +G +V+ D I D+ R W + +DK ++R
Sbjct: 177 FKLEFGVNPDGEVVVGDEISPDTCRFW-DAETEESLDKDIFR 217
>UniRef50_Q7M9X5 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=18; Bacteria|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Wolinella succinogenes
Length = 236
Score = 124 bits (300), Expect = 4e-27
Identities = 77/220 (35%), Positives = 122/220 (55%)
Frame = +1
Query: 154 LLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKSA 333
++ EGK K++++ P + KD +TA + K + GK A++ Q + ++F++L++
Sbjct: 6 MIYEGKGKKLYNT-SHPDQVVAEFKDDLTAFNAEKKGNEAGKGALNCQISTEIFKLLEAE 64
Query: 334 GIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETFFK 513
GIKT F+K E L K+ +IPIE VTR +ATGS KR G+ EG E ++K
Sbjct: 65 GIKTHFIKQLDEKNMLCKRVSIIPIEVVTRNIATGSLSKR-LGIKEGSVLPFSLVEFYYK 123
Query: 514 DDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMK 693
DDA DP ++E I K + ++E++++++ I EIL + + L+D K
Sbjct: 124 DDALGDPIMNDEHAILLK-----CVNSQEELEFLKETAREINEILRSFFDSKGLNLVDFK 178
Query: 694 IEFGVDTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYR 813
+EFG D EG+I+LAD I DS R W +DK +R
Sbjct: 179 LEFGKDIEGNILLADEISPDSCRFWDKKTNE-KLDKDRFR 217
>UniRef50_O57978 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=6; cellular organisms|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Pyrococcus horikoshii
Length = 238
Score = 124 bits (300), Expect = 4e-27
Identities = 75/217 (34%), Positives = 115/217 (52%)
Frame = +1
Query: 163 EGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKSAGIK 342
EGK K++ + D ++ KD TA DG K +GK ++ Q + F++L+ GIK
Sbjct: 9 EGKAKKMIPIDDDK--LIMEFKDDATAFDGTKKARFKGKGWLNAQLSVIFFKLLEEHGIK 66
Query: 343 TAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETFFKDDA 522
T F+ +A + +K +M P+E V R + GS KR P +PEG+ P E ++K+D
Sbjct: 67 THFIGVAGGNRLIVEKLDMYPLEVVVRNVVAGSLKKRLP-LPEGYELPEPIVELYYKNDE 125
Query: 523 NHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEF 702
HDP + ++ L I DE+ + + + + EIL+ A + L+D K+EF
Sbjct: 126 LHDPMIN-------YYHAKVLGISLDEIKKIEEIALKVNEILKDYLAKKGIILVDFKLEF 178
Query: 703 GVDTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYR 813
G D G IVLAD I D+ R W + KR +DK V+R
Sbjct: 179 GKDKNGDIVLADEISPDTCRFWDAKTKR-SLDKDVFR 214
>UniRef50_Q58987 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=5; Euryarchaeota|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Methanococcus jannaschii
Length = 242
Score = 124 bits (298), Expect = 7e-27
Identities = 73/220 (33%), Positives = 126/220 (57%), Gaps = 1/220 (0%)
Frame = +1
Query: 157 LIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDL-EGKAAISNQTNAKVFEILKSA 333
L GK K ++++ D L+ +D ITAG+G K HD+ +GK ++ ++K+FE L+
Sbjct: 14 LYSGKAKSIYEIDDDK--VLIEFRDDITAGNGAK-HDVKQGKGYLNALISSKLFEALEEN 70
Query: 334 GIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETFFK 513
G+KT ++K ++KK E+IPIE + R +A GS +R P EG P + +K
Sbjct: 71 GVKTHYIKYIEPRYMIAKKVEIIPIEVIVRNIAAGSLCRRYP-FEEGKELPFPIVQFDYK 129
Query: 514 DDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMK 693
+D DP +E+ ++ L R+E++ +++ + + E+L+K + + L+D K
Sbjct: 130 NDEYGDPMLNEDIAVALG------LATREELNKIKEIALKVNEVLKKLFDEKGIILVDFK 183
Query: 694 IEFGVDTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYR 813
IE G D EG++++AD I D+ RLW + R ++DK V+R
Sbjct: 184 IEIGKDREGNLLVADEISPDTMRLWDK-ETRDVLDKDVFR 222
>UniRef50_Q92AN6 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=17; Bacteria|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Listeria innocua
Length = 237
Score = 123 bits (297), Expect = 9e-27
Identities = 76/221 (34%), Positives = 119/221 (53%)
Frame = +1
Query: 151 KLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKS 330
+LL EGK K++F D+ G + KD TA +GV+ GK ++NQ + +F L
Sbjct: 4 ELLYEGKAKRLFKT-DEAGVLRVAYKDDATALNGVRKESFAGKGELNNQITSLIFSYLAK 62
Query: 331 AGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETFF 510
GI + F++ SET L K+ +IP+E V R + GS KR G EG E ++
Sbjct: 63 EGISSHFIRAISETEQLVKEVSIIPLEVVVRNVMAGSLAKR-LGKEEGEEIPNAIVEFYY 121
Query: 511 KDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDM 690
KDDA DP +++ ++ + +E+D +R+A I ++L++ + + LID
Sbjct: 122 KDDALDDPFINDDHVLYLD------IATTNEMDTIRQAARSINKVLQELFNQMNITLIDF 175
Query: 691 KIEFGVDTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYR 813
K+EFG D G+I+LAD I D+ RLW + +DK V+R
Sbjct: 176 KLEFGRDAAGNILLADEISPDTCRLWDK-ETNQKLDKDVFR 215
>UniRef50_UPI00015BB105 Cluster:
phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=1; Ignicoccus hospitalis KIN4/I|Rep:
phosphoribosylaminoimidazole-succinocarboxamide synthase
- Ignicoccus hospitalis KIN4/I
Length = 235
Score = 122 bits (294), Expect = 2e-26
Identities = 71/221 (32%), Positives = 123/221 (55%)
Frame = +1
Query: 151 KLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKS 330
KL+ EGKTK+V+D+ D+ LL KD TA DG K +++GK ++ + + + L+
Sbjct: 2 KLIYEGKTKKVYDMDDK---VLLKFKDVFTAFDGKKVEEVKGKGKVNAEFTELLMKYLEQ 58
Query: 331 AGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETFF 510
G+KT F+ +E ++ K + +P+E++ R A GS LKR P + +G R P E +
Sbjct: 59 HGVKTHFLS-RNEDEIVAIKTKPLPLEFIVRNYAYGSLLKRLPILEKGQRLLTPVFEVHY 117
Query: 511 KDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDM 690
K D HDP +E+ ++A ++ +D + +R+ T+ + E+L + + LID
Sbjct: 118 KSDELHDPLLAEDDPVAAG------IVSKDVMKTIRETTLKVNELLTELFEKAGFKLIDF 171
Query: 691 KIEFGVDTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYR 813
K+E+G+ +G +VL D + DS+R G+ DK ++R
Sbjct: 172 KVEYGITEDGRVVLIDELSPDSFRAHKGGE---AYDKDLFR 209
>UniRef50_Q87Y59 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=12; Gammaproteobacteria|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Pseudomonas syringae pv. tomato
Length = 236
Score = 122 bits (294), Expect = 2e-26
Identities = 78/219 (35%), Positives = 113/219 (51%)
Frame = +1
Query: 157 LIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKSAG 336
L GK K V+ D LL D +A DG + L+ K ++N+ NA + + L+ AG
Sbjct: 7 LYRGKAKSVYKTDDADRLILLFRNDT-SAFDGKRIEQLDRKGTVNNKFNAFIMQKLEEAG 65
Query: 337 IKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETFFKD 516
I T F K+ + L KK +MIP+E V R A GS +KR G+ EG + P E F KD
Sbjct: 66 IPTQFDKLLGDNECLVKKLDMIPVECVVRNYAAGSLVKR-LGIEEGTKLNPYTFELFLKD 124
Query: 517 DANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKI 696
DA DP +E +++ F + +++ M++ +I + E+L K + L+D K+
Sbjct: 125 DAKGDPFINESHVVA--FGWG----TAEQLVRMKELSIKVNEVLTKLFDDAGLLLVDFKL 178
Query: 697 EFGVDTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYR 813
EFGV G IVL D D RLW D R +DK +R
Sbjct: 179 EFGV-FHGEIVLGDEFSPDGCRLWDK-DTRKKMDKDRFR 215
>UniRef50_Q8ES99 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=10; Firmicutes|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Oceanobacillus iheyensis
Length = 237
Score = 122 bits (294), Expect = 2e-26
Identities = 77/221 (34%), Positives = 117/221 (52%), Gaps = 1/221 (0%)
Frame = +1
Query: 154 LLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKSA 333
LL EGK K+V+ + +L K+ TA +G K EGK ++N+ ++ +F+ L A
Sbjct: 5 LLYEGKAKKVYQSSEDEHQLVLSYKNDATAFNGEKKSQFEGKGRLNNEISSLIFQRLHEA 64
Query: 334 GIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETFFK 513
GI T F+K T + +K +IP+E V R LATGS KR G+ E FTPP E F+K
Sbjct: 65 GISTHFIKRLDSTQQIVQKTSIIPLEVVIRNLATGSITKR-LGIKEKVSFTPPLLELFYK 123
Query: 514 DDANHDPQWSEEQ-IISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDM 690
DDA DP ++E ++ L +D+ + A IF+ + L+D
Sbjct: 124 DDALGDPLINDEHALLLTDITETELAEIKDKAREVNAALQEIFQSI-------GIKLVDF 176
Query: 691 KIEFGVDTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYR 813
K+EFG + +G I+L+D + D+ RLW + +DK V+R
Sbjct: 177 KLEFGRNKDGEILLSDEVSPDTCRLWDI-ETNEKLDKDVFR 216
>UniRef50_Q8G5A9 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=5; Bacteria|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Bifidobacterium longum
Length = 250
Score = 120 bits (289), Expect = 8e-26
Identities = 80/227 (35%), Positives = 117/227 (51%), Gaps = 3/227 (1%)
Frame = +1
Query: 142 KLGKLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEI 321
KL KL EGK KQ++ D P + K+ TAGDG K D GK ++N +F++
Sbjct: 3 KLEKLY-EGKAKQLY-ATDDPEVLWVEYKNTATAGDGEKKEDFTGKGRLNNLITTIIFDL 60
Query: 322 LKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQE 501
LK GI + +K +T L +K M P+E V R +A G F R GV EG P E
Sbjct: 61 LKKRGIDSHLIKRVDDTGQLVRKVNMFPLEIVLRNVAAGHFCSR-LGVEEGLPLKEPVLE 119
Query: 502 TFFKDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCAL 681
F K+D HDP +++ +++ + R+++ + I E L + +A D L
Sbjct: 120 YFLKNDDLHDPFVNDDDLVALG------VCTREDLAEIAPLARKINEALIEIFAKIDVKL 173
Query: 682 IDMKIEFGVDTEGSIVLADVIDSDSWRLWPSGD---KRLMVDKQVYR 813
+D KIE G T+G+++LAD I DS RLW D K +DK ++R
Sbjct: 174 VDFKIEMGRATDGTLLLADEITPDSCRLWDQKDHSGKVEHLDKDLFR 220
>UniRef50_A6QAA3 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=2; Epsilonproteobacteria|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Sulfurovum sp. (strain NBC37-1)
Length = 244
Score = 119 bits (287), Expect = 1e-25
Identities = 74/220 (33%), Positives = 121/220 (55%)
Frame = +1
Query: 154 LLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKSA 333
L+ EGK K+++ + Y KD +TA +G K EGK A++N+ + ++F+ L
Sbjct: 11 LVYEGKAKKIWSTEYEDLYISEF-KDDLTAFNGEKKSSEEGKGALNNKISTELFKYLNKK 69
Query: 334 GIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETFFK 513
GI T FV++ + L KK ++I IE + R +ATGS L RN G+ +G E +K
Sbjct: 70 GIPTHFVEMLDDNHMLHKKADVILIEVIVRNIATGS-LSRNLGIEDGKVLPFTLVEFDYK 128
Query: 514 DDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMK 693
+D DP+ +++ + L+ E+DY+R I ++L+ +A R+ L+D K
Sbjct: 129 NDELGDPKLNDQHCLILN-----LVHDTSELDYIRYMARRINDLLKAFYAQRNLTLVDFK 183
Query: 694 IEFGVDTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYR 813
+EFG D +G+I+L D + D++RLW S M DK +R
Sbjct: 184 LEFGRDMDGNIILIDELSPDNFRLWDSVSGESM-DKDRFR 222
>UniRef50_Q7V5X1 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=15; Bacteria|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Prochlorococcus marinus (strain MIT 9313)
Length = 242
Score = 118 bits (285), Expect = 3e-25
Identities = 73/225 (32%), Positives = 127/225 (56%), Gaps = 3/225 (1%)
Frame = +1
Query: 148 GKLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILK 327
G LL EGK K+VF DQP L+ K+ TA + +K +LEGK ++ Q +A++FE+L+
Sbjct: 6 GPLLYEGKAKRVF-AADQPDRVLVEFKNDATAFNALKRAELEGKGRLNCQISARLFEMLE 64
Query: 328 SAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETF 507
G+ T ++ + SET L + ++IP+E V R +ATGS ++ P + G +P + +
Sbjct: 65 REGVPTHYLDLVSETWMLVQHVDVIPLEVVIRNVATGSLCQQTP-IAAGTELSPALLDLY 123
Query: 508 FKDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALID 687
+KDD DP SE ++ GL+ + ++ + A + ++L + D L+D
Sbjct: 124 YKDDNLGDPLLSE-----SRLQLLGLISSQQRLEIEQLAR-RVNQLLLSFFESLDLLLVD 177
Query: 688 MKIEFGVDTEGSIVLADVIDSDSWRLWP---SGDKRLMVDKQVYR 813
K+E G+++ G++++AD I D+ RLW S + ++DK +R
Sbjct: 178 FKLELGLNSAGTLLVADEISPDTCRLWDHRNSDPQARILDKDRFR 222
>UniRef50_P0A7E0 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=50; Proteobacteria|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Shigella flexneri
Length = 237
Score = 112 bits (270), Expect = 2e-23
Identities = 70/219 (31%), Positives = 110/219 (50%)
Frame = +1
Query: 157 LIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKSAG 336
L GK K V+ + P +L ++ +AGDG + + K ++N+ N + L AG
Sbjct: 7 LYRGKAKTVYST-ENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
Query: 337 IKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETFFKD 516
I T ++ S+T L KK +M+P+E V R A GS +KR G+ EG PP + F K+
Sbjct: 66 IPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKR-LGIEEGIELNPPLFDLFLKN 124
Query: 517 DANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKI 696
DA HDP +E F + + ++ + M++ T ++L+K + L+D K+
Sbjct: 125 DAMHDPMVNES--YCETFGW----VSKENLARMKELTYKANDVLKKLFDDAGLILVDFKL 178
Query: 697 EFGVDTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYR 813
EFG+ +G +VL D D RLW M DK +R
Sbjct: 179 EFGL-YKGEVVLGDEFSPDGSRLWDKETLEKM-DKDRFR 215
>UniRef50_A3H6Y2 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=1; Caldivirga maquilingensis IC-167|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Caldivirga maquilingensis IC-167
Length = 241
Score = 111 bits (267), Expect = 4e-23
Identities = 69/222 (31%), Positives = 116/222 (52%)
Frame = +1
Query: 148 GKLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILK 327
GKL+ EGK K+V+ + ++ ++ KD +TA DG + GK ++ A L
Sbjct: 6 GKLIYEGKAKRVYLINNEE--LVMEFKDEVTALDGARKEYAPGKGKLAASQTAFFMSYLN 63
Query: 328 SAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETF 507
+G++T F+ + ++ MIP+E + R A GSF++R P + +FT P E
Sbjct: 64 ESGVRTHFINWDGDRRIHVRRLRMIPVEVIVRNYAYGSFIRRMPLIKPLTKFTTPLVEFH 123
Query: 508 FKDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALID 687
K+D HDP E II A L ++V +R ++ + +L + L+D
Sbjct: 124 LKNDELHDPLILIEDIIEAG------LTSMEQVMEIRSVSLKVNHLLSELLGKYGLTLVD 177
Query: 688 MKIEFGVDTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYR 813
K+EFGV++ G++VLAD + D+ R+ +G K L DK+++R
Sbjct: 178 FKLEFGVNSNGALVLADELSGDTMRVLMNG-KHL--DKELFR 216
>UniRef50_P73471 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=19; Bacteria|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Synechocystis sp. (strain PCC 6803)
Length = 264
Score = 109 bits (263), Expect = 1e-22
Identities = 78/233 (33%), Positives = 120/233 (51%), Gaps = 6/233 (2%)
Frame = +1
Query: 133 GQYKLGKLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKV 312
G + + KL EGK K ++ D P L + KD TA + K ++GK AI+ +A +
Sbjct: 13 GNFSMEKLY-EGKAKILYPTED-PDVLLTIFKDDATAFNAQKKGQIQGKGAINCAISAAL 70
Query: 313 FEILKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPP 492
F L++ GI T ++ L K +IP+E V R +A GS K+ G+ EG P
Sbjct: 71 FRWLETLGIPTHYIDCPQNDQMLVKAVNIIPLEVVVRNIAAGSLCKQT-GLKEGLVLPNP 129
Query: 493 KQETFFKDDANHDPQWSEEQIISAKFNYNGLLIG-RDE--VDYMRKATILIFEILEKAWA 663
E +FKDDA DP + E+ LL+G DE + ++ + I + L++ +A
Sbjct: 130 LVEFYFKDDALGDPLLTWER---------ALLLGVTDEARLQTLKDLALNINQHLQRFFA 180
Query: 664 LRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRLWPSGD---KRLMVDKQVYR 813
D L+D K+EFG D +G I+LAD I D+ RLW + + ++DK +R
Sbjct: 181 QCDITLVDFKLEFGGDRQGKIILADEISPDTCRLWDNAQADPQARVLDKDRFR 233
>UniRef50_Q9X0X0 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=4; Thermotogaceae|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Thermotoga maritima
Length = 230
Score = 109 bits (262), Expect = 2e-22
Identities = 78/217 (35%), Positives = 110/217 (50%)
Frame = +1
Query: 163 EGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKSAGIK 342
EGKTK V D Y LL KD ITAGDG+K L GK +I +T A + + L GIK
Sbjct: 4 EGKTKIVKVTGD---YALLEFKDDITAGDGLKHDVLTGKGSICAETTAILMKYLSEKGIK 60
Query: 343 TAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETFFKDDA 522
T V+ +M P+E V R GSF++R G EG P E F KDD
Sbjct: 61 THLVEYIPPRTLKVIPLKMFPLEVVVRLKKAGSFVRRYGGA-EGEDLPVPLVEFFIKDDE 119
Query: 523 NHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEF 702
HDP + + G+ + + + M++A + I L++ + + L D+K EF
Sbjct: 120 RHDPMVCVDHL-----EILGIAT-KKQAEKMKEAAVKITLALKEFFERANFELWDIKYEF 173
Query: 703 GVDTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYR 813
G+D +G++VL D I D++RL G+ + DK VYR
Sbjct: 174 GLDKDGNVVLGDEISPDTFRLRKKGE---IFDKDVYR 207
>UniRef50_Q8ZCD2 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=17; Enterobacteriaceae|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Yersinia pestis
Length = 237
Score = 108 bits (260), Expect = 3e-22
Identities = 73/221 (33%), Positives = 109/221 (49%), Gaps = 2/221 (0%)
Frame = +1
Query: 157 LIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKSAG 336
L GK K V+ + P +L ++ +A DG + + K ++N+ N + L+ AG
Sbjct: 7 LYRGKAKTVYTT-ENPDLLVLEFRNDTSALDGQRIEQFDRKGMVNNKFNHFIMTKLEEAG 65
Query: 337 IKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETFFKD 516
I T ++ S+T L KK EMIP+E V R A GS +KR G+ EG PP + F K+
Sbjct: 66 IPTQMERLLSDTEVLVKKLEMIPVECVIRNRAAGSLVKR-LGIEEGLSLNPPLFDLFLKN 124
Query: 517 DANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKI 696
DA HDP +E + + L E+ Y+ ++L K + L+D K+
Sbjct: 125 DAMHDPMVNESYCKTFGWATEAQLARMKELSYLAN------DVLSKLFDDAGLILVDFKL 178
Query: 697 EFGVDTEGSIVLADVIDSDSWRLWPSGDKRLM--VDKQVYR 813
EFG+ G +VL D D RLW DK+ + +DK YR
Sbjct: 179 EFGL-FNGEVVLGDEFSPDGSRLW---DKKTLNKMDKDRYR 215
>UniRef50_Q8TIS9 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=8; cellular organisms|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Methanosarcina acetivorans
Length = 237
Score = 107 bits (257), Expect = 6e-22
Identities = 72/219 (32%), Positives = 114/219 (52%)
Frame = +1
Query: 157 LIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKSAG 336
L GK K ++ D P + ++ +TA +G K ++E K + Q + K+FE+L+++G
Sbjct: 6 LYSGKAKTIY-ATDNPDTLIAEFRNSLTAFNGEKKGEMEKKGYYNAQISKKIFEMLEASG 64
Query: 337 IKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETFFKD 516
IKT FV + S+ L KK E+I IE + R +A GS K+ P + EG F P FK
Sbjct: 65 IKTHFVSMLSDIEMLVKKVEIIKIEVIVRNIAAGSITKKYP-MKEGTIFESPVLVFDFKS 123
Query: 517 DANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKI 696
D DP +++ ++ + R+E+ +RK + I E+L + L D K+
Sbjct: 124 DEYGDPMLNDDIAVALG------IATREELATLRKLALRINELLVPYLDEKGILLPDFKL 177
Query: 697 EFGVDTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYR 813
EFG +G I+L+D I D+ R W + M DK V+R
Sbjct: 178 EFG-RRDGEIILSDEISCDTCRFWDKKTGQSM-DKDVFR 214
>UniRef50_Q7VAN8 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=9; Prochlorococcus marinus|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Prochlorococcus marinus
Length = 244
Score = 105 bits (252), Expect = 3e-21
Identities = 63/207 (30%), Positives = 111/207 (53%)
Frame = +1
Query: 148 GKLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILK 327
G LL EGK K+V+ D L+ K+ TA + K LEGK +++ + + ++F++L+
Sbjct: 6 GALLYEGKAKRVY-YTDNSDEFLVHFKNDATAFNAKKHAQLEGKGSLNCEISTEIFKLLE 64
Query: 328 SAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETF 507
GI T F+ + + L ++ ++IPIE V R +A+GS K+ P P G + P + +
Sbjct: 65 RNGIATHFLNLEDDCWMLVQRVDVIPIEIVIRNIASGSLCKQTPIAP-GTELSRPLMDLY 123
Query: 508 FKDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALID 687
KDD DP +EE+I L+ + +++ ++ + + L++ D L+D
Sbjct: 124 LKDDVLEDPLLTEERIDLLN------LLSSSQRKEIQRLSLRVNDCLKEFMKGLDLLLVD 177
Query: 688 MKIEFGVDTEGSIVLADVIDSDSWRLW 768
K+E G + G +++AD I DS R+W
Sbjct: 178 FKLEMGFNGSGQLLIADEISPDSCRIW 204
>UniRef50_A4M8A0 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=1; Petrotoga mobilis SJ95|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Petrotoga mobilis SJ95
Length = 238
Score = 103 bits (247), Expect = 1e-20
Identities = 68/222 (30%), Positives = 111/222 (50%), Gaps = 1/222 (0%)
Frame = +1
Query: 151 KLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKS 330
+LL EGK K+V+ ++ L+ KD +TA +G+K + K I+ + + FE+L +
Sbjct: 8 ELLYEGKAKKVYKFDEKK--LLIEFKDDVTAFNGLKKDQILNKGKINKEISKFFFEMLNN 65
Query: 331 AGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETFF 510
GI T ++ E +F++K ++IP+E + R G F KR GV +G F P E
Sbjct: 66 QGINTHYINDYDENSFVAKWTDLIPLEVIIRNYTAGGFCKRY-GVKKGLMFDYPLVEFSL 124
Query: 511 KDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDM 690
K+D DP +++ I+ K +L DE+ + K + IL + L+D
Sbjct: 125 KNDELGDPMIAKDAILLLKITTENVL---DEIASISKK---VNNILSDYLKSKGIILVDF 178
Query: 691 KIEFGVD-TEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYR 813
K+EFG+ + + L D I D+ R W + +DK VYR
Sbjct: 179 KLEFGISKNDNKVTLIDEISPDTCRFWDANTME-SLDKDVYR 219
>UniRef50_Q3YRB0 Cluster: SAICAR synthetase; n=2;
Anaplasmataceae|Rep: SAICAR synthetase - Ehrlichia canis
(strain Jake)
Length = 258
Score = 103 bits (246), Expect = 1e-20
Identities = 70/222 (31%), Positives = 115/222 (51%), Gaps = 3/222 (1%)
Frame = +1
Query: 157 LIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKSAG 336
+ EGK K +F P + KD +TA + KA + K ++N ++ + + L + G
Sbjct: 16 IYEGKAKIIF-ATSNPLEVIQHFKDEVTAFNNKKADVINEKGIVNNYISSFLMKELTNKG 74
Query: 337 IKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETFFKD 516
IKT F+ + ++ L KK +IP+E V R L+ G+F KR + +G F P E ++K
Sbjct: 75 IKTHFISLLNQREQLVKKVSIIPLEIVVRNLSAGNFSKRFQ-IADGTSFKSPIIEFYYKS 133
Query: 517 DANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKI 696
D DP S+ I+S ++ N E++ ++ ++ I EIL + + L+D K+
Sbjct: 134 DKLSDPMVSDGHILSFQWLTN------QELEKIKMLSLKINEILSEIFLNVGIKLVDFKL 187
Query: 697 EFGV---DTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYR 813
EFG + ++LAD I D+ RLW D R +DK +YR
Sbjct: 188 EFGKLYNNKASDLLLADEISPDTCRLWNISDNR-KLDKDLYR 228
>UniRef50_Q9RXT0 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=37; cellular organisms|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Deinococcus radiodurans
Length = 237
Score = 101 bits (241), Expect = 6e-20
Identities = 71/222 (31%), Positives = 110/222 (49%)
Frame = +1
Query: 148 GKLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILK 327
G++ EGK K+V+ + P ++ KD TA + K + GK A +N A ++ L+
Sbjct: 4 GEMKYEGKAKRVY-ATENPHEYVVEYKDDATAFNAQKRGEWAGKGATNNAITAHLYPQLE 62
Query: 328 SAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETF 507
+AGI T F++ S+ K ++P+E + R +A GSF KR GV EG P E
Sbjct: 63 AAGIPTHFLEKLSDREQRVKAVTIVPVEVIVRNVAAGSFSKR-LGVEEGTPLPRPVVEYC 121
Query: 508 FKDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALID 687
+K DA DP + + ++ + D++ +R+ + I + L + R LID
Sbjct: 122 YKSDALGDPLINTDTAVALGW------ASEDDLKRIRELALQIRDFLVPYFEKRGVRLID 175
Query: 688 MKIEFGVDTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYR 813
K+EFG G IVLAD I D+ R W + M DK +R
Sbjct: 176 FKLEFGKLPSGEIVLADEISPDTCRFWDAETNEKM-DKDRFR 216
>UniRef50_Q8ZZK5 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=4; Pyrobaculum|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Pyrobaculum aerophilum
Length = 234
Score = 99 bits (238), Expect = 1e-19
Identities = 69/221 (31%), Positives = 112/221 (50%)
Frame = +1
Query: 151 KLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKS 330
+L+ EGK K+V+ D + ++ KD +TAGDG GK A++ + +A +F+ L S
Sbjct: 2 ELVYEGKAKRVYKHGD---FYIMEFKDEVTAGDGAVKAQAPGKGALTAELSALLFKYL-S 57
Query: 331 AGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETFF 510
++T FV+ A E+IP+E + R A GS L+R P + E + P E +
Sbjct: 58 RVVETHFVEYKPPNALAVIPAEVIPVEVIVRFKAYGSQLRRMPRLRELQHLSRPLVEFHY 117
Query: 511 KDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDM 690
KDDA HDP ++++ A L EV+ + + + L +A C ID+
Sbjct: 118 KDDALHDPLVYPQEVVEAG------LAAPQEVEAIEEMAVRAASALRDLYARAGCDFIDV 171
Query: 691 KIEFGVDTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYR 813
K EFG G ++L D + D++RL G+ +DK+ +R
Sbjct: 172 KFEFG-RRGGRLILVDEVSGDTFRLLCRGEH---LDKEYFR 208
>UniRef50_Q6LZT3 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=5; Methanococcus|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Methanococcus maripaludis
Length = 246
Score = 96.7 bits (230), Expect = 1e-18
Identities = 63/234 (26%), Positives = 117/234 (50%), Gaps = 6/234 (2%)
Frame = +1
Query: 130 VGQYKLGKLLIE-----GKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLE-GKAAIS 291
+ +Y + K+L GK K ++ + + L+ +D ITAG+G K HD++ GK ++
Sbjct: 1 MSEYDISKILANEPIYAGKAKSIYKIEENEKEVLVEFRDDITAGNGAK-HDVKSGKGYLN 59
Query: 292 NQTNAKVFEILKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPE 471
+ ++F +L+ + T ++ ++K ++IP+E + R +A GS K+ P +
Sbjct: 60 TLISTELFNVLEKNNVPTHLIEYIEPNIMIAKNVKIIPLEVIVRNIAAGSLCKKYP-FEQ 118
Query: 472 GFRFTPPKQETFFKDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILE 651
G + +K+D DP + E I L +E+ ++K + + ++L+
Sbjct: 119 GQVLKTAVTQYDYKNDDYGDPMLNNEIAIELG------LATEEELVEIKKLALKVNDVLK 172
Query: 652 KAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYR 813
+ + L+D KIE G +G IV+AD I D+ RLW K ++ DK V+R
Sbjct: 173 GFFDEKGIMLVDFKIEVGKTADGQIVVADEISPDTMRLWDKETKDVL-DKDVFR 225
>UniRef50_Q03Y92 Cluster:
Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR)
synthase; n=4; Lactobacillales|Rep:
Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR)
synthase - Leuconostoc mesenteroides subsp.
mesenteroides (strain ATCC 8293 /NCDO 523)
Length = 249
Score = 93.5 bits (222), Expect = 1e-17
Identities = 65/222 (29%), Positives = 112/222 (50%)
Frame = +1
Query: 148 GKLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILK 327
G+L +GK KQV+ D P + D+ TA +G ++ K +++ + +FE L
Sbjct: 15 GELKYQGKAKQVY-FTDNPTILWVHYMDQATALNGKVHENIPEKGQLNSAISHILFEHLT 73
Query: 328 SAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETF 507
GI+ ++ SET L +++PIE VTR A+G F+ + P + TP QE +
Sbjct: 74 RQGIENHYLSSVSETDELDLALDILPIEVVTRNYASGHFVSKFNATPMQ-KLTPVVQEFY 132
Query: 508 FKDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALID 687
+K D DP ++ QI++ F E+ +R + + L + + + L+D
Sbjct: 133 YKSDELDDPFMNDSQILALGF------ATLSELTKLRAYAQEVNQALTEIFDEININLVD 186
Query: 688 MKIEFGVDTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYR 813
K+E+G D+EG ++LAD + D+ RL + +DK V+R
Sbjct: 187 FKLEYGRDSEGKLILADELSPDNMRLVDQKTGK-SLDKDVFR 227
>UniRef50_Q98NM8 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
1; n=116; Bacteria|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
1 - Rhizobium loti (Mesorhizobium loti)
Length = 264
Score = 93.5 bits (222), Expect = 1e-17
Identities = 70/207 (33%), Positives = 103/207 (49%), Gaps = 3/207 (1%)
Frame = +1
Query: 157 LIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKSAG 336
+ EGK K +++ P+ PG + KD TA + K ++GK ++N+ + +F L G
Sbjct: 7 IYEGKAKILYEGPE-PGTLIQFFKDDATAFNKKKHEVVDGKGVLNNRISEHIFNHLNRMG 65
Query: 337 IKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETFFKD 516
I T F++ + L K+ E+IP+E V R +A GS KR G+ EG E ++K
Sbjct: 66 IPTHFIRRLNMREQLIKEVEIIPLEVVVRNVAAGSLSKR-LGIEEGTVLPRSIIEFYYKA 124
Query: 517 DANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKI 696
DA DP SEE I + F + E+D + I + + L + L+D KI
Sbjct: 125 DALDDPMVSEEHITA--FGW----ASPQEIDDVMALAIRVNDFLSGLFMGVGIQLVDFKI 178
Query: 697 EFGVDTEGS---IVLADVIDSDSWRLW 768
E G EG IV+AD I DS RLW
Sbjct: 179 ECGRLFEGDMMRIVVADEISPDSCRLW 205
>UniRef50_Q88U22 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=3; Lactobacillales|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Lactobacillus plantarum
Length = 243
Score = 91.5 bits (217), Expect = 4e-17
Identities = 67/220 (30%), Positives = 109/220 (49%)
Frame = +1
Query: 154 LLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKSA 333
LL GK K ++ D P + D+ TA +G + ++ K ++N+ + +F+ L +
Sbjct: 10 LLYTGKAKAMYATND-PEILWVEYLDQATALNGKRKVPIDQKGRLNNRIASLIFKDLANH 68
Query: 334 GIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETFFK 513
GI F++ S+ L ++ MIP+E V R A+GSF +R VP +F P E F+K
Sbjct: 69 GIANHFIEQPSDYVQLVRRVTMIPLETVVRNAASGSF-ERKFAVPHLTKFAEPVLEFFYK 127
Query: 514 DDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMK 693
D DP ++ QI + + V +++ + + + L +A L+D K
Sbjct: 128 SDQLDDPFINDSQIHALNVATPAI------VAEIKRQALQVNQRLTAIFAAMGVQLVDFK 181
Query: 694 IEFGVDTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYR 813
IEFG+ T G ++LAD I DS RL +DK V+R
Sbjct: 182 IEFGLTTTGKVLLADEISPDSCRL-VDLKTGASLDKDVFR 220
>UniRef50_Q5JD27 Cluster:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase;
n=1; Thermococcus kodakarensis KOD1|Rep:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase
- Pyrococcus kodakaraensis (Thermococcus kodakaraensis)
Length = 219
Score = 78.2 bits (184), Expect = 4e-13
Identities = 63/214 (29%), Positives = 101/214 (47%), Gaps = 7/214 (3%)
Frame = +1
Query: 157 LIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVK-------AHDLEGKAAISNQTNAKVF 315
+ GKTK V++ D P Y + KD + DG + + GK +I F
Sbjct: 4 IYRGKTKDVYE--DGP-YLVFYFKDSVLGEDGREDTGGNEIVGERRGKGSIVLDETEFFF 60
Query: 316 EILKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPK 495
+L+ GI+T FV+ E + E IP+E + R LA GSFL+R G + +
Sbjct: 61 RLLEEKGIRTHFVERIDERRARFLRAERIPLEVIYRELAYGSFLRRYQGWVKELKPLGIV 120
Query: 496 QETFFKDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDC 675
+ T KDD+ DP +EE ++ G EV M++ T + EIL + ++ +
Sbjct: 121 EFT-LKDDSLKDPLITEEAVVKLGIASEG------EVREMKEKTRKVAEILREFFSSKGL 173
Query: 676 ALIDMKIEFGVDTEGSIVLADVIDSDSWRLWPSG 777
L+D K+EFG G +++ D + D+ R+ G
Sbjct: 174 QLVDFKLEFG-RRNGELIVIDELSGDTMRVIKDG 206
>UniRef50_Q466M0 Cluster: Phosphoribosylaminoimidazole carboxylase,
phosphoribosylaminoribosylaminoimidazole
succinocarboxamide synthetase; n=3; Archaea|Rep:
Phosphoribosylaminoimidazole carboxylase,
phosphoribosylaminoribosylaminoimidazole
succinocarboxamide synthetase - Methanosarcina barkeri
(strain Fusaro / DSM 804)
Length = 296
Score = 73.7 bits (173), Expect = 1e-11
Identities = 47/153 (30%), Positives = 74/153 (48%), Gaps = 9/153 (5%)
Frame = +1
Query: 154 LLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKSA 333
++ +GKTK + P + L ++ +T GD + + G A +F +L
Sbjct: 2 IISQGKTKVILPGP-RKNTVFLETRNVLTGGDAARRETIAGIGIHKTTQAANIFSLLNRK 60
Query: 334 GIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNP--GVPEG--FRFTPPKQE 501
G+ TAF++ S L +CEM+P+E V RR A GS+L+R+P G EG +RF P E
Sbjct: 61 GLPTAFIERTSPNTLLCYQCEMLPLELVVRRYAWGSYLQRHPEYGNQEGTAYRFDEPVWE 120
Query: 502 TFFK-----DDANHDPQWSEEQIISAKFNYNGL 585
F K P +E+ +F +NG+
Sbjct: 121 IFHKLSVVGFPVTDKPYQIDEEAAREQFLHNGI 153
Score = 60.1 bits (139), Expect = 1e-07
Identities = 33/81 (40%), Positives = 50/81 (61%), Gaps = 7/81 (8%)
Frame = +1
Query: 595 RDEVDYMRKATIL-IFEILEKAW-----ALRDCALIDMKIEFGVDTEGS-IVLADVIDSD 753
++E+DY+ +A +L F LE AW L+D+KIE G + + IV+ADVID+D
Sbjct: 195 QEELDYIVQAIMLPTFLALEDAWRKIMTTYGPMELVDLKIEVGRRLDNNRIVIADVIDND 254
Query: 754 SWRLWPSGDKRLMVDKQVYRN 816
SWR+W G+ +DKQ +R+
Sbjct: 255 SWRIWSGGNPEKQLDKQCFRD 275
>UniRef50_Q648Z8 Cluster:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase;
n=1; uncultured archaeon GZfos35D7|Rep:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase
- uncultured archaeon GZfos35D7
Length = 249
Score = 70.5 bits (165), Expect = 9e-11
Identities = 71/232 (30%), Positives = 107/232 (46%), Gaps = 16/232 (6%)
Frame = +1
Query: 166 GKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKSAGIKT 345
GK+K +F+ + G DR TA DGVK + K + + + FEIL+ AGI T
Sbjct: 9 GKSKDIFE---EDGKTFFEFTDRTTAFDGVKEDEFSHKGEVCCRLSTYWFEILEEAGIPT 65
Query: 346 AFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNP---GVPE------GFRFTPPKQ 498
F + +++PIE + R GS L+R+ +P G R
Sbjct: 66 HFRAFVPPNIMEVEPLDILPIEVIWRNFVAGSILRRHERGESLPIEIEPRLGARIPGGMV 125
Query: 499 ETFFKDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCA 678
E K +A P E++I+ NG L E+D +R+ T L EI+ + R
Sbjct: 126 EFTTKFEAKDRPI-DEQEILD-----NGWLTSA-ELDSIRECTRLTNEIMSERLLKRGII 178
Query: 679 LIDMKIEFGVDTEGS--IVLADVIDS-DSWRLW--PSGDKRLM--VDKQVYR 813
L D KIEFG D + I+LAD + + D R W + ++ ++ +DK VYR
Sbjct: 179 LADFKIEFGRDKNAAEKILLADEVGTPDGCRFWDRDAYEQGVIESLDKDVYR 230
>UniRef50_Q0AXN6 Cluster:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase;
n=1; Syntrophomonas wolfei subsp. wolfei str.
Goettingen|Rep:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase
- Syntrophomonas wolfei subsp. wolfei (strain
Goettingen)
Length = 225
Score = 69.3 bits (162), Expect = 2e-10
Identities = 66/219 (30%), Positives = 107/219 (48%), Gaps = 10/219 (4%)
Frame = +1
Query: 151 KLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDG-------VKAHDLEGKAAISNQTNAK 309
KLL +GKTK V+++ DQ C+L KD IT DG LEGK S + +
Sbjct: 2 KLLYDGKTKAVYEL-DQDK-CVLEFKDDITGEDGRIDPGSNYVLGKLEGKGKSSLKMSQH 59
Query: 310 VFEILKSAGIKTAFVKI-ASETAFLSKKCEMIP--IEWVTRRLATGSFLKRNPGVPEGFR 480
F++L+ G+ + ++ ++ + K + +E V R A GSFL+R + F+
Sbjct: 60 FFKLLQEQGVPSHYIDSDLAKNNMVVWKAQTFGQGLEVVCRFKAYGSFLRRYARYAQEFQ 119
Query: 481 FTPPKQETFFKDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAW 660
E KDD DP ++E +I GLL R E++ ++ + I++
Sbjct: 120 PLNALVEVTLKDDERGDPLINDESLIQL-----GLLTER-ELEIIKALARKVAVIVKNDL 173
Query: 661 ALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRLWPSG 777
AL+ L+D+K EFG + IV+ D I D+ R++ +G
Sbjct: 174 ALKGLELVDIKFEFGRIGQ-EIVVIDDISGDNMRVFKNG 211
>UniRef50_A7DSW8 Cluster:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase;
n=1; Candidatus Nitrosopumilus maritimus SCM1|Rep:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase
- Candidatus Nitrosopumilus maritimus SCM1
Length = 274
Score = 67.7 bits (158), Expect = 6e-10
Identities = 67/233 (28%), Positives = 100/233 (42%), Gaps = 11/233 (4%)
Frame = +1
Query: 151 KLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKS 330
+ L GK K ++DV + L DR++A D D+ K + + F L
Sbjct: 2 EFLTSGKVKDLYDVDEST--LLFKFSDRVSAYDVKFKQDIPRKGEVLCKFAEFWFNELD- 58
Query: 331 AGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKR----NPGVPEGFRFTPPKQ 498
+ F+K SE L KK +M+PIE V R GS + R VPEG T Q
Sbjct: 59 --VPNHFIKRESENEILVKKMKMLPIECVVRGYFYGSLVSRWKKGEVQVPEGTNTTLAAQ 116
Query: 499 ETFFKDDANHDPQWSEEQIISAKFN--YNGLLIGRDEVDYMRKATILIFEILEKAWALRD 672
+ DP E I N L+ ++ +++ K +I I++ + K
Sbjct: 117 ----LPEPIFDPTTKSEHDIPIDKNKAIEMNLVSEEQYNWLEKTSIEIYKKMAKITDDVG 172
Query: 673 CALIDMKIEFGVDTEGSIVLADVIDSDSWRLWPS-----GDKRLMVDKQVYRN 816
L D+K+EFG+ + I L D I D +RLWP G + DKQ+ R+
Sbjct: 173 FILADLKLEFGI-LDDQITLGDSIGPDEYRLWPKDSFEVGKIQEAYDKQLLRD 224
>UniRef50_A0RW02 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide (SAICAR)
synthase; n=1; Cenarchaeum symbiosum|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide (SAICAR)
synthase - Cenarchaeum symbiosum
Length = 273
Score = 63.3 bits (147), Expect = 1e-08
Identities = 61/229 (26%), Positives = 98/229 (42%), Gaps = 7/229 (3%)
Frame = +1
Query: 151 KLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEI-LK 327
+ L GK K ++++ + G L DR++A D VK H+ + + K E +
Sbjct: 2 RFLTSGKVKDIYEL--EGGRLLFRFSDRVSAYD-VKFHE---EIPRKGEVLCKFAEYWFR 55
Query: 328 SAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETF 507
I + FV+ ++T + K EM+PIE + R GS R PP +
Sbjct: 56 RLPIPSHFVERRADTEIIVNKMEMLPIECIVRGYYYGSMAARVEKGEISMAGGPPPLASR 115
Query: 508 FKDDANHDPQWSEEQI-ISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALI 684
+ SE + + K + L+ E D++ +I ++ + A L
Sbjct: 116 LPEPFFDPTTKSEHDLPVDRKSAVSEGLVTEKEYDWLSAKSIEVYNAMSVAAEAAGFVLA 175
Query: 685 DMKIEFGVDTEGSIVLADVIDSDSWRLWPS-----GDKRLMVDKQVYRN 816
D+K+EFG GSI L D I D RLWP+ G + DKQ+ R+
Sbjct: 176 DVKLEFG-RLGGSITLGDSIGPDECRLWPAEQYSPGAIQEAFDKQILRD 223
>UniRef50_Q4UML8 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=8; Rickettsia|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Rickettsia felis (Rickettsia azadi)
Length = 236
Score = 61.7 bits (143), Expect = 4e-08
Identities = 50/207 (24%), Positives = 100/207 (48%), Gaps = 3/207 (1%)
Frame = +1
Query: 157 LIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKSAG 336
L +G +K ++ ++ ++ D +T G + ++ GK ++N ++ + + L+ G
Sbjct: 5 LYKGSSKILYSA-EEDFLLIMAFSDNVTLESG-EIIEISGKGVLNNNISSFLMDKLEMNG 62
Query: 337 IKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETFFKD 516
I+ F++ + L + E+ P++ + +A G F+K G+ EG+ F P + +
Sbjct: 63 IENHFIEKINMREQLIQYVEVFPVQVIISSVACGRFVKEF-GMDEGYVFDKPIIDFKVRS 121
Query: 517 DANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKI 696
P +E QI+ N+ L RDE+ +++ + I++ L + L++ K+
Sbjct: 122 REFKYPIVNEYQIL----NFGWLT--RDEIKAVKEQALRIYDFLSGLFIGVGIRLVECKL 175
Query: 697 EFG---VDTEGSIVLADVIDSDSWRLW 768
EFG E I+L D I D+ RLW
Sbjct: 176 EFGRVFNGEESIIMLTDEISPDNCRLW 202
>UniRef50_P38025 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase, chloroplast precursor; n=13; cellular
organisms|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase, chloroplast precursor - Arabidopsis thaliana
(Mouse-ear cress)
Length = 411
Score = 59.3 bits (137), Expect = 2e-07
Identities = 63/226 (27%), Positives = 97/226 (42%), Gaps = 17/226 (7%)
Frame = +1
Query: 151 KLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKS 330
K I+GK + ++D D Y +L+ DR++A D A + K + N+T+ F +
Sbjct: 107 KSRIKGKVRDIYDAGD---YLVLITTDRLSAFDRNLA-SIPFKGQVLNETSLWWFNNTQH 162
Query: 331 AGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGS-----FLKRNPGV--------PE 471
A V ++KKC + PIE+V R TGS + N GV +
Sbjct: 163 I-TPNAIVSSPDRNVVIAKKCSVFPIEFVVRGYVTGSTDTSLWTVYNKGVRNYCGNELSD 221
Query: 472 GF---RFTPPKQETFFKDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFE 642
G + P T A+HD S +I+ F + + E D + +FE
Sbjct: 222 GLVKNQKLPANILTPTTKAADHDVPISPNEIVEGGF------MTQAEFDEASMKALSLFE 275
Query: 643 ILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDS-DSWRLWPSG 777
+ L+D K EFG ++GSI+L D I + DS R W +G
Sbjct: 276 FGQGVAKKHGLILVDTKYEFGRSSDGSILLIDEIHTPDSSRYWLAG 321
>UniRef50_A5CCM2 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamidesynthase;
n=1; Orientia tsutsugamushi Boryong|Rep:
Phosphoribosylaminoimidazole-succinocarboxamidesynthase
- Orientia tsutsugamushi (strain Boryong) (Rickettsia
tsutsugamushi)
Length = 252
Score = 57.6 bits (133), Expect = 7e-07
Identities = 48/207 (23%), Positives = 99/207 (47%), Gaps = 3/207 (1%)
Frame = +1
Query: 157 LIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKSAG 336
+ EG +K ++ + + + RI A K + GK ++N + +F+ + G
Sbjct: 17 IFEGNSKIIYRIDEHTLIQFFKDDMRINAE---KVIQVSGKGVLNNVISNYIFKRVSMVG 73
Query: 337 IKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETFFKD 516
I ++ + L +IP++ +A+G ++ + G+ +G+ F P + K
Sbjct: 74 INHHLIQKINMREQLIYTLNIIPVKVCITNIASGRYVSQF-GIEDGYVFDTPIIDFMVKH 132
Query: 517 DANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKI 696
AN+ P +E+Q+I KFN+ + E+ ++ + ++ L +A + L++ ++
Sbjct: 133 GANNYPIINEDQMI--KFNW----VDYYELKNIKTLALKLYTFLVGMFASINIRLVECQL 186
Query: 697 EFGV--DTEGSIVL-ADVIDSDSWRLW 768
EFG + G I+L AD I D+ +LW
Sbjct: 187 EFGRINNLSGDIILLADEITPDTCKLW 213
>UniRef50_Q895U7 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=8; cellular organisms|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Clostridium tetani
Length = 227
Score = 57.2 bits (132), Expect = 9e-07
Identities = 60/220 (27%), Positives = 97/220 (44%), Gaps = 11/220 (5%)
Frame = +1
Query: 154 LLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGV-------KAHDLEGKAAISNQTNAKV 312
++ +GKTK VF + D G LL KD +T +GV +EG + +
Sbjct: 3 VVYKGKTKDVFLLED--GNYLLKFKDDVTGENGVFDPGANSVGLTMEGAGRAALRLTKLF 60
Query: 313 FEILKSAGIKTAFVKIASETAFLSKKCEMI---PIEWVTRRLATGSFLKRNPGVPEGFRF 483
FE LK I T ++ E + K I +E + R A GSF++R + +
Sbjct: 61 FERLKEEKIPTHYIDSNVEEGTMKVKPAKIFGNGLEVICRYRAVGSFMRRYGMYAKEGQV 120
Query: 484 TPPKQETFFKDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWA 663
E KDD DP +++ + + G+L R E D ++ T I I++ +
Sbjct: 121 LDAFVEVTLKDDERQDPPITKDAL-----DMLGILSLR-EYDILKDLTKKISGIVKDELS 174
Query: 664 LRDCALIDMKIEFG-VDTEGSIVLADVIDSDSWRLWPSGD 780
+ L D+K+EFG +D + I L D I + R + G+
Sbjct: 175 KKGIELYDIKLEFGRIDEDNHIALIDEISGGNMRAYKDGE 214
>UniRef50_A6BCY4 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=1; Dorea longicatena DSM 13814|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Dorea longicatena DSM 13814
Length = 381
Score = 56.8 bits (131), Expect = 1e-06
Identities = 63/234 (26%), Positives = 103/234 (44%), Gaps = 27/234 (11%)
Frame = +1
Query: 151 KLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILK- 327
K + EGK ++++D D +++ DRI+ D + + + K + Q + F++ K
Sbjct: 96 KPIKEGKVREIYDNGDS---LIMVATDRISCFDVILKNVVSKKGTVLTQMSKFWFDLTKD 152
Query: 328 -------SAGIKTA---FVKIASE-TAFLSKKCEMIPIEWVTRRLATGS---FLKRNPGV 465
S +K F K + + + KK EM+PIE + R TGS K N V
Sbjct: 153 ILPNHMISTDVKDMPEFFQKPEYDGNSMMCKKLEMLPIECIVRGYITGSGWKSYKENGTV 212
Query: 466 -----PEGFRFTPPKQETFF-----KDDANHDPQWSEEQIISAKFNY-NGLLIGRDEVDY 612
PEG + + E + + +HD S EQ I+ Y G G +
Sbjct: 213 CGIKLPEGLKESDKLPEPIYTPSTKAEIGDHDENISYEQSIAHLEKYFPGK--GEEYAAK 270
Query: 613 MRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLAD-VIDSDSWRLWP 771
+R TI +++ R + D K EFG+D G++V+ D ++ DS R WP
Sbjct: 271 LRDCTIALYKKCADYALSRGIIIADTKFEFGLDENGNMVIGDEMLTPDSSRFWP 324
>UniRef50_Q73PW0 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=1; Treponema denticola|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Treponema denticola
Length = 316
Score = 56.4 bits (130), Expect = 2e-06
Identities = 57/215 (26%), Positives = 94/215 (43%), Gaps = 14/215 (6%)
Frame = +1
Query: 166 GKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKSAGIKT 345
GK + + P++ G L++ DRI+A D V L K + NQ + FE K IK
Sbjct: 21 GKVRDWYS-PEE-GKRLIVTTDRISAFDRVLTA-LPYKGQVLNQLSLWWFENTKDI-IKN 76
Query: 346 AFVKIASETAFLSKKCEMIPIEWVTRRLATG----------SFLKRNP---GVPEGFRFT 486
+ + + + +PIE + R TG S +RN PEG +
Sbjct: 77 HIISCPDPNCIIVTEVKPLPIEVIVRGYITGVTSTALWYRYSLGERNIYGYDFPEGLKKN 136
Query: 487 PPKQETFFKDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWAL 666
+ P +E++ + G L +++ D+++KA + +FE +K+
Sbjct: 137 QALPKPIITPTTKGGPTGHDERLTCDEVVSQGYL-SKEQWDFVQKAALALFERGQKSAKE 195
Query: 667 RDCALIDMKIEFGVDTEGSIVLADVIDS-DSWRLW 768
L+D K EFGVD +I+L D + + DS R W
Sbjct: 196 AGLILVDTKYEFGVDKNNNILLIDEVHTPDSSRYW 230
>UniRef50_Q8F0I0 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=4; Leptospira|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Leptospira interrogans
Length = 285
Score = 56.0 bits (129), Expect = 2e-06
Identities = 69/252 (27%), Positives = 118/252 (46%), Gaps = 34/252 (13%)
Frame = +1
Query: 163 EGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKSAG-- 336
+GK + ++D+ D+ +L + DRI+A D V + K + N+ + FE K
Sbjct: 6 KGKVRDIYDLGDK---LILSSSDRISAFDVVFPQLVPDKGKVLNRISVSWFEFFKDVPNH 62
Query: 337 -IKT--AFVKIASET-------AFLSKKCEMIPIEWVTRRLATGSFLK--RNPG------ 462
++T + I + + L KKC+ I E V R +GS K +N G
Sbjct: 63 ILETDVKYFPIPFQNHPDLEGRSVLVKKCKRIDYECVVRGYISGSGWKEYKNDGTLAGIK 122
Query: 463 VPEGFRFTPPKQETFF----KDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATI 630
+P GF+ + E F K+D HD SE+++ + IG++ + +++ +I
Sbjct: 123 LPSGFKESQKLPEPVFTPAVKNDQGHDENISEKEMENR--------IGKELFNILKEKSI 174
Query: 631 LIF----EILEKAWALRDCALIDMKIEFGVDTEGSIVLAD-VIDSDSWRLWPS-----GD 780
IF E+++KA + L D K EFG+ +G ++L D ++ DS R W + G
Sbjct: 175 SIFLRASEVVDKAGII----LCDTKFEFGI-LDGQVILIDELLTPDSSRYWSTDTYSVGI 229
Query: 781 KRLMVDKQVYRN 816
+DKQ+ RN
Sbjct: 230 SPPSLDKQILRN 241
>UniRef50_A4SAQ9 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=1; Ostreococcus lucimarinus CCE9901|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Ostreococcus lucimarinus CCE9901
Length = 367
Score = 55.2 bits (127), Expect = 4e-06
Identities = 61/221 (27%), Positives = 97/221 (43%), Gaps = 17/221 (7%)
Frame = +1
Query: 163 EGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKSAGIK 342
EGK + + D + + DR +A D A+ + K A+ NQT+ F+ + +
Sbjct: 73 EGKVRDTYVTGDT---MIAVTTDRQSAFDRHLAY-IPFKGAVLNQTSQWWFKQTEHI-VP 127
Query: 343 TAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLK----------RN---PGVPEGF-- 477
A V + ++CE+ PIE+V R TGS RN + +G
Sbjct: 128 NAVVATPDPNVTVMRRCEVFPIEFVVRGYLTGSTSTSLWTHYKTGGRNYCGNALDDGMVK 187
Query: 478 -RFTPPKQETFFKDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEK 654
+ P T + HD S E I+ + + +D++DY T+ +F ++
Sbjct: 188 NQKLPANIVTPTTKEKEHDRPISLEDIVKEGW------MKQDDLDYCVAKTLEVFAYAQE 241
Query: 655 AWALRDCALIDMKIEFGVDTEGSIVLADVIDS-DSWRLWPS 774
A R L+D K EFG D +G+I L D I++ DS R W S
Sbjct: 242 VAATRGLILVDTKYEFGRDADGTIRLIDEINTPDSSRYWLS 282
>UniRef50_A7BA15 Cluster: Putative uncharacterized protein; n=1;
Actinomyces odontolyticus ATCC 17982|Rep: Putative
uncharacterized protein - Actinomyces odontolyticus ATCC
17982
Length = 333
Score = 52.8 bits (121), Expect = 2e-05
Identities = 46/144 (31%), Positives = 64/144 (44%), Gaps = 10/144 (6%)
Frame = +1
Query: 373 AFLSKKCEMIPIEWVTRRLATGSFLK--RNPG------VPEGFRFTPPKQETFFKDDANH 528
A + + MIPIE V R TGS L R G +PEG +E F A
Sbjct: 128 AVVCRSLHMIPIECVVRGYLTGSGLAEYRESGSVCGIKLPEGLTEASRLEEPIFTPAAKA 187
Query: 529 DPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGV 708
+ +E I F IG + +R +I ++ A R + D K EFG+
Sbjct: 188 ELGEHDENI---TFEQTVERIGEELAVAIRDLSIALYRAARDIAAERGIIIADTKFEFGI 244
Query: 709 D-TEGSIVLAD-VIDSDSWRLWPS 774
D T G++VLAD ++ DS R WP+
Sbjct: 245 DVTTGALVLADEILTPDSSRFWPA 268
>UniRef50_Q3WE59 Cluster: SAICAR synthetase; n=5; Bacteria|Rep:
SAICAR synthetase - Frankia sp. EAN1pec
Length = 354
Score = 49.6 bits (113), Expect = 2e-04
Identities = 67/260 (25%), Positives = 108/260 (41%), Gaps = 25/260 (9%)
Frame = +1
Query: 112 MSHPKQVGQYKLGKLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAIS 291
++H + G LG GK +++F + D LL+ DRI+A D V ++ K A+
Sbjct: 54 LTHEEFAGLTHLGS----GKVRELFAIGDDA--VLLVASDRISAFDVVLPTEIPDKGAVL 107
Query: 292 NQTNAKVFE----ILKSAGIKTAFVKIASETA----------FLSKKCEMIPIEWVTRRL 429
+ F+ ++ S I ++ + +E A L ++ +M+ IE V R
Sbjct: 108 TGLSLWWFDQLGDLVPSHVISSSVDEYPAELAPYAEQLRGRSMLCRRLDMVQIECVARGY 167
Query: 430 ATGSFLK--RNPGVPEGFRFTPPKQETFFKDDANHDPQWSE---EQIISAKFNYNGLLIG 594
TGS LK R G G ++ + + P E + + +G
Sbjct: 168 LTGSGLKDYRRSGTVSGHPLPAGLEDGSRLPNPIYTPSTKAPIGEHDENISRDDAAGRVG 227
Query: 595 RDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLAD-VIDSDSWRLWP 771
+ + + T+ IF A R L D K EFG D +G + LAD V+ DS R WP
Sbjct: 228 AELAAELERLTLQIFGRASDLAAERGILLADTKFEFGHDADGVLRLADEVLTPDSSRFWP 287
Query: 772 S-----GDKRLMVDKQVYRN 816
+ G + DKQ R+
Sbjct: 288 ADAWTPGGTQPSYDKQFIRD 307
>UniRef50_P43060 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=11; cellular organisms|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Candida albicans (Yeast)
Length = 291
Score = 49.2 bits (112), Expect = 2e-04
Identities = 54/237 (22%), Positives = 97/237 (40%), Gaps = 18/237 (7%)
Frame = +1
Query: 154 LLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKSA 333
L+ GK + ++ V D L + DRI+A D + A+ + K I + + F L
Sbjct: 12 LIARGKVRDIYQVDDNT--LLFVATDRISAYDVIMANGIPNKGKILTKLSEFWFAFLPID 69
Query: 334 G--IK-TAFVKIASETAF---------LSKKCEMIPIEWVTRRLATGSFLKRNP------ 459
IK F K + L +K ++IP+E + R TGS K
Sbjct: 70 NHLIKGDIFEKYPQLEKYRDQLEGRSLLVRKLKLIPLEVIVRGYITGSGWKEYTKSKTVH 129
Query: 460 GVPEGFRFTPPKQETFFKDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIF 639
G+P G + F + +E I + + ++G++ D + K I ++
Sbjct: 130 GIPIGDVVESQQITPIFTPSTKAEQGEHDENITKEQADK---IVGKELCDRIEKIAIDLY 186
Query: 640 EILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVY 810
A + + D K EFG+D + +++ +V+ DS R W + +L ++ Y
Sbjct: 187 TKARDYAATKGIIIADTKFEFGLDGDKIVLVDEVLTPDSSRFWSAAKYKLGQSQESY 243
>UniRef50_Q1IPE1 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=7; Bacteria|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Acidobacteria bacterium (strain Ellin345)
Length = 318
Score = 48.8 bits (111), Expect = 3e-04
Identities = 53/225 (23%), Positives = 95/225 (42%), Gaps = 18/225 (8%)
Frame = +1
Query: 151 KLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKS 330
+L GK + ++ V + L + DRI+A D V A + K + Q + F+ LK+
Sbjct: 35 ELYASGKVRDIYKVDSD--HLLFIASDRISAFDYVLASGIPEKGRVLTQISLFWFDFLKN 92
Query: 331 A---GIKTAFV-KIASET----------AFLSKKCEMIPIEWVTRRLATGSFLK--RNPG 462
+ TA V K +E + L + +MI +E V R +GS K + G
Sbjct: 93 IVDNHLVTADVNKFPAELKAHEAQLHGRSMLVQHAQMIQVECVVRGYLSGSGWKEYKKDG 152
Query: 463 VPEGFRFTPPKQETFFKDDANHDPQWSEEQIISAKFNYNGLL--IGRDEVDYMRKATILI 636
G QE+ + P + +++ ++ G D + +R+ +I I
Sbjct: 153 AVCGIELPKGLQESDKLPEPIFTPATKAQTGHDENISFDRMVQVTGGDLSEKLREVSIKI 212
Query: 637 FEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRLWP 771
++ + + D K EFG+ +G ++ +V+ DS R WP
Sbjct: 213 YKAAADYALTKGIIIADTKFEFGMTPKGLVLADEVLTPDSSRFWP 257
>UniRef50_Q7MVR8 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=17; Bacteroidetes|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Porphyromonas gingivalis (Bacteroides gingivalis)
Length = 313
Score = 48.0 bits (109), Expect = 5e-04
Identities = 54/218 (24%), Positives = 90/218 (41%), Gaps = 14/218 (6%)
Frame = +1
Query: 151 KLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKS 330
K + GK + V+ + + +++ DRI+A D V + K + NQ A + +
Sbjct: 16 KAVYHGKVRDVYTLEND--LLVMIATDRISAFDVVLPAGIPYKGQVLNQIAAHYLDATRD 73
Query: 331 AGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPG---------VPEGFR- 480
+ + + +CE +E V R TGS + +PEG R
Sbjct: 74 I-VPNWKIATPDPMVTIGHRCEPFKVEMVIRGYITGSAWRAYAAGERVLCGLPLPEGMRE 132
Query: 481 ---FTPPKQETFFKDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILE 651
F P K D HD S ++II+ L+ +++ + + + T +FE
Sbjct: 133 NQRFEHPIITPTTKADEGHDENISRQEIIAQG------LVSKEDYEQIERYTYALFERGT 186
Query: 652 KAWALRDCALIDMKIEFGVDTEGSIVLADVIDS-DSWR 762
+ A + L+D K EFG +G I L D I + DS R
Sbjct: 187 QMAAEKGLILVDTKYEFG-KKDGKIYLIDEIHTPDSSR 223
>UniRef50_A1G3E0 Cluster: SAICAR synthetase; n=1; Salinispora
arenicola CNS205|Rep: SAICAR synthetase - Salinispora
arenicola CNS205
Length = 236
Score = 46.4 bits (105), Expect = 0.002
Identities = 33/130 (25%), Positives = 61/130 (46%), Gaps = 1/130 (0%)
Frame = +1
Query: 148 GKLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILK 327
G+ I G++K+V+ V +PG C++ + + + ++G A + V +L
Sbjct: 9 GRPDITGRSKKVWFV--EPGRCVVEMIPSLRSFTHDRDELMDGTAELRLDFFEYVSGVLA 66
Query: 328 SAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGV-PEGFRFTPPKQET 504
AG+ T F + +L+ +P E + + ATGS ++ PG+ EG F PP +
Sbjct: 67 KAGVPTVFRERLGPITYLADYRPAVPFEVIVKNRATGSTTRKYPGLFEEGRVFAPPVVKF 126
Query: 505 FFKDDANHDP 534
++ D P
Sbjct: 127 DYRTDPEDQP 136
>UniRef50_Q3ET89 Cluster:
Phosphoribosylamidoimidazole-succinocarboxamide
synthase; n=1; Bacillus thuringiensis serovar
israelensis ATCC 35646|Rep:
Phosphoribosylamidoimidazole-succinocarboxamide synthase
- Bacillus thuringiensis serovar israelensis ATCC 35646
Length = 137
Score = 45.6 bits (103), Expect = 0.003
Identities = 27/82 (32%), Positives = 42/82 (51%)
Frame = +1
Query: 151 KLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKS 330
+LL EGK K+++ + + KD TA +G K + GK ++N+ +F L+
Sbjct: 24 ELLYEGKAKRIYRT-ESADMVWVEYKDSATAFNGEKKETITGKGRLNNEITTLLFRKLQE 82
Query: 331 AGIKTAFVKIASETAFLSKKCE 396
GIKT V+ SET +K E
Sbjct: 83 VGIKTHLVEKLSETEQTCQKSE 104
>UniRef50_Q1MRH1 Cluster:
Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR)
synthase; n=7; Proteobacteria|Rep:
Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR)
synthase - Lawsonia intracellularis (strain PHE/MN1-00)
Length = 298
Score = 44.4 bits (100), Expect = 0.007
Identities = 63/250 (25%), Positives = 101/250 (40%), Gaps = 29/250 (11%)
Frame = +1
Query: 154 LLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNA---KVFEIL 324
L GK + ++ + DQ L++ DR++A D + + K I NQ K F+ L
Sbjct: 14 LYSRGKVRDIYSI-DQ-NTLLIITTDRMSAFDVILQEPIPYKGIILNQLTLFWMKKFQHL 71
Query: 325 KSAGIKTAFV-----------KIASETAFLSKKCEMIPIEWVTRRLATGS----FLKRNP 459
I + V + + L KK +PIE + R +GS +L N
Sbjct: 72 VPNHIIESNVDNFPSNLEPYKNLLEGRSVLVKKTTPLPIECIVRGYISGSGWKDYLTTNS 131
Query: 460 ----GVPEGFRFTPPKQETFFKDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKAT 627
+P G + + F D +E I + L+G+D + +
Sbjct: 132 ICGYPLPPGLKESEKLATALFTPSTKADLGQHDENISIETTEH---LLGKDTTTLVASLS 188
Query: 628 ILIFEILEKAWAL-RDCALIDMKIEFGVDTEGSIVLAD-VIDSDSWRLWPS-----GDKR 786
+L+F WA R + D K EFG+ +G ++L D V+ DS R WP+ G +
Sbjct: 189 LLMFNEAS-VWAEDRGIIIADTKFEFGI-LDGQVILIDEVLTPDSSRFWPTKNYIPGKSQ 246
Query: 787 LMVDKQVYRN 816
DKQ R+
Sbjct: 247 PSFDKQYLRD 256
>UniRef50_Q7UJ19 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=2; Planctomycetaceae|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Rhodopirellula baltica
Length = 320
Score = 43.2 bits (97), Expect = 0.015
Identities = 39/155 (25%), Positives = 66/155 (42%), Gaps = 10/155 (6%)
Frame = +1
Query: 379 LSKKCEMIPIEWVTRRLATGSFLKRNPGVPE--GFRFTPPKQETFFKDDANHDPQWSEEQ 552
+++K ++P E V R GS K E G ++ +A P E+
Sbjct: 125 VTRKASVVPFECVVRGYLEGSGWKEYQATGEVCGVSLPAGLKQCDQLSEAIFTPATKAEE 184
Query: 553 IISAKFNYNGLL--IGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSI 726
+Y + +G ++ +R+ ++ I++ K A R + D K EFGV +G +
Sbjct: 185 GHDENVSYEVMSQSLGEEQSSQLRRMSLAIYQDASKIAAERGLLIADTKFEFGV-VDGEL 243
Query: 727 VLAD-VIDSDSWRLWPS-----GDKRLMVDKQVYR 813
+L D V+ DS R W + G + DKQ R
Sbjct: 244 MLIDEVLTPDSSRFWAADEYEPGHSQRSFDKQFVR 278
>UniRef50_Q98I23 Cluster: Putative
phosphoribosylaminoimidazole-succinocarboxamide synthase
2; n=16; Alphaproteobacteria|Rep: Putative
phosphoribosylaminoimidazole-succinocarboxamide synthase
2 - Rhizobium loti (Mesorhizobium loti)
Length = 313
Score = 43.2 bits (97), Expect = 0.015
Identities = 60/222 (27%), Positives = 95/222 (42%), Gaps = 20/222 (9%)
Frame = +1
Query: 163 EGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKSAGIK 342
+GK ++ +D+ D G +++ DR++A D + + K I QT FE ++A I
Sbjct: 17 KGKVRENYDLAD--GRRIIIATDRLSAFDIILT-SIPFKGEILTQTARYWFE--ETADIC 71
Query: 343 TAFV-KIASETAFLSKKCEMIPIEWVTRRLATG----SFLKR---------NPGVPEGFR 480
V + + + +++P+E V R G S L R +P+G R
Sbjct: 72 PNHVLEYPDPNVVVGTRLDILPVEIVVRGYLAGTTSTSILTRYRRGEREMYGMRLPDGLR 131
Query: 481 -----FTPPKQETFFKDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEI 645
P T D HD S +I++ GLL + + D + + +F
Sbjct: 132 DNEKLAAPVITPTSKAADGGHDEPLSRAEILA-----QGLLT-QAQWDTVSDYALKLFAR 185
Query: 646 LEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDS-DSWRLW 768
+ A R L D K EFG D G+I+LAD I + DS R W
Sbjct: 186 GQARAAERGLILADTKYEFGTDKNGTIILADEIHTPDSSRYW 227
>UniRef50_A7H9G3 Cluster:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase;
n=4; Cystobacterineae|Rep:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase
- Anaeromyxobacter sp. Fw109-5
Length = 320
Score = 42.7 bits (96), Expect = 0.020
Identities = 65/240 (27%), Positives = 108/240 (45%), Gaps = 19/240 (7%)
Frame = +1
Query: 106 AKMSHP-KQVGQYKLGKLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKA 282
A++ H +Q+ LG+L GK + + D+ +++ DR++A D V + K
Sbjct: 9 AQLPHTLRQLDLPSLGELY-RGKVRDNYSRGDR---IVMVTTDRVSAFDHVLG-TIPFKG 63
Query: 283 AISNQTNAKVFEILKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNP- 459
+ ++ A FE +K T V + + + K+ + +PIE V R TGS +
Sbjct: 64 EVLSRLTAFWFEKVKDVA-PTHVVDLPDPSVMVVKRAKPLPIEIVIRGYITGSLWRDYQA 122
Query: 460 ------GV--PEGFR----FTPPKQETFFKDD-ANHDPQWSEEQIISAKFNYNGLLIGRD 600
G+ P+G R F P K + HD SE++++S GL+
Sbjct: 123 GKAGAYGIEWPKGLRKDQRFDRPIITPSTKAEYGKHDEPISEQELLS-----QGLVAP-- 175
Query: 601 EVDYMRKATILIFEILEKA--WAL-RDCALIDMKIEFGVDTEGSIVLADVIDS-DSWRLW 768
+ R+AT + + + WAL R L+D K E GV +G +V+ D I + DS R W
Sbjct: 176 --ELWREATAVAERLFARGQEWALSRGLILVDTKYEMGV-VDGKLVVIDEIHTPDSSRYW 232
>UniRef50_A0Q508 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=14; Gammaproteobacteria|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Francisella tularensis subsp. novicida (strain U112)
Length = 770
Score = 42.7 bits (96), Expect = 0.020
Identities = 54/219 (24%), Positives = 94/219 (42%), Gaps = 18/219 (8%)
Frame = +1
Query: 166 GKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKSAGIKT 345
GK + ++ D+ +L++ DR +A D + K I Q++ F+ +K
Sbjct: 28 GKVRDMYFTDDKS---ILISTDRQSAFDRSLGF-IPFKGQILAQSSVWWFKETAHI-VKN 82
Query: 346 AFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLK------RNPG-------VPEGFRFT 486
F+ +++K +++PIE+V R TGS +N +PEG +
Sbjct: 83 HFIDSPDPNVVIARKAKVLPIEFVVRGYITGSTSTSLWTHYKNGSRDYCGNILPEGLKKN 142
Query: 487 ---PPKQETFFKDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKA 657
P T + +HD S E I+ + + + + D+ + + +FE +K
Sbjct: 143 QKLPQNILTPTTKEQDHDRPISAEDIVKEGW------LTQQQWDFASQKALELFEFGQKK 196
Query: 658 WALRDCALIDMKIEFGVDTE-GSIVLADVIDS-DSWRLW 768
L D K EFG+D + G I+L D I + DS R W
Sbjct: 197 ALEHGLILADTKYEFGIDEQTGEIILIDEIHTPDSSRFW 235
>UniRef50_Q5IWX2 Cluster: Plastid
phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=1; Prototheca wickerhamii|Rep: Plastid
phosphoribosylaminoimidazole-succinocarboxamide synthase
- Prototheca wickerhamii
Length = 245
Score = 41.9 bits (94), Expect = 0.036
Identities = 30/92 (32%), Positives = 46/92 (50%)
Frame = +1
Query: 166 GKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKSAGIKT 345
GK + +D+ D+ L++ DR +A D A + K I NQT+A E +S +
Sbjct: 108 GKVRDTYDLGDK---LLIVTTDRQSAFDRHLA-SIPFKGQILNQTSAWWMEATRSI-VPN 162
Query: 346 AFVKIASETAFLSKKCEMIPIEWVTRRLATGS 441
A + + A L KC + P+E+V R TGS
Sbjct: 163 ALLGLPDPNASLMTKCTVFPVEFVCRGYMTGS 194
>UniRef50_Q9C1J4 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=14; cellular organisms|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Pichia pastoris (Yeast)
Length = 304
Score = 41.9 bits (94), Expect = 0.036
Identities = 52/235 (22%), Positives = 95/235 (40%), Gaps = 30/235 (12%)
Frame = +1
Query: 154 LLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILK-- 327
L+ +GK + ++ V + L + DRI+A D + + + K I Q + F+ L
Sbjct: 14 LIAKGKVRDIYAVDENN--LLFVATDRISAYDVIMTNGIPDKGKILTQLSVFWFDFLAPY 71
Query: 328 ------SAGIKTAFVKIASETA------------FLSKKCEMIPIEWVTRRLATGSFLK- 450
++ K F + S+ + + KK +IP+E + R TGS K
Sbjct: 72 IKNHLVASNDKEVFALLPSKLSEEKYKSQLEGRSLIVKKHRLIPLEAIVRGYITGSAWKE 131
Query: 451 -RNPGVPEGFRFTPPKQETFFKDDANHDPQWSE-------EQIISAKFNYNGLLIGRDEV 606
+N G + + E + DA P ++ E + ++G+D
Sbjct: 132 YKNSKTVHGVKV---ENENLQESDAFPTPIFTPSTKAEQGEHDENISIEQAAEIVGKDIC 188
Query: 607 DYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLAD-VIDSDSWRLW 768
+ + + ++ + L+ + D K EFG+D +VL D V+ DS R W
Sbjct: 189 EKVAVKAVELYSAAKNFALLKGIIIADTKFEFGLDENNELVLVDEVLTPDSSRFW 243
>UniRef50_A7CZ13 Cluster:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase;
n=1; Opitutaceae bacterium TAV2|Rep:
Phosphoribosylaminoimidazolesuccinocarboxamide synthase
- Opitutaceae bacterium TAV2
Length = 306
Score = 41.5 bits (93), Expect = 0.047
Identities = 20/65 (30%), Positives = 35/65 (53%), Gaps = 1/65 (1%)
Frame = +1
Query: 586 LIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLAD-VIDSDSWR 762
++G + ++ A++ ++ + A L D K EFG D G++VL D ++ DS R
Sbjct: 187 IVGPALYEQVKAASLALYSLGHDKAARAGMILADTKFEFGTDAAGNLVLIDEILTPDSSR 246
Query: 763 LWPSG 777
WP+G
Sbjct: 247 YWPAG 251
>UniRef50_Q8A004 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=12; Bacteria|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Bacteroides thetaiotaomicron
Length = 314
Score = 40.3 bits (90), Expect = 0.11
Identities = 53/218 (24%), Positives = 86/218 (39%), Gaps = 10/218 (4%)
Frame = +1
Query: 151 KLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKS 330
K + GK + V+++ + +++ DRI+A D V + K + NQ AK +
Sbjct: 15 KSVYHGKVRDVYNINGEK--LVMVATDRISAFDVVLPEGIPYKGQMLNQIAAKFLDATTD 72
Query: 331 AGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKR-NPGV--------PEGFRF 483
+ + CE P+E + R GS + GV P+G R
Sbjct: 73 I-CPNWKMATPDPMVTVGVLCEGFPVEMIVRGYLCGSAWRTYKSGVREICGVKLPDGMRE 131
Query: 484 TPPKQETFFKDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWA 663
E + +E I + GL +E + + K T+ +F+ + A
Sbjct: 132 NEKFPEPIVTPTTKAEMGLHDEDISKEEILKQGLATP-EEYETLEKYTLALFKRGTEIAA 190
Query: 664 LRDCALIDMKIEFGVDTEGSIVLADVIDS-DSWRLWPS 774
R L+D K EFG G+I L D I + DS R + S
Sbjct: 191 ERGLILVDTKYEFG-KHNGTIYLMDEIHTPDSSRYFYS 227
>UniRef50_Q67KF6 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=1; Symbiobacterium thermophilum|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Symbiobacterium thermophilum
Length = 299
Score = 37.1 bits (82), Expect = 1.0
Identities = 45/227 (19%), Positives = 88/227 (38%), Gaps = 21/227 (9%)
Frame = +1
Query: 157 LIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVF------- 315
L GK +++F++ L++ DR++A D V + GK + Q +A F
Sbjct: 9 LHRGKVREMFEL--DADRLLMVATDRLSAFDVVFPQGIPGKGRVLTQLSALWFGATRHIV 66
Query: 316 ------EILKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPG----- 462
+ L G+ ++ + + ++ I +E V R GS K
Sbjct: 67 ANHLVSDDLGGLGLPGDVRRLLEGRSLVVRRARRIDVECVVRGYLAGSGWKEYQASGTVC 126
Query: 463 ---VPEGFRFTPPKQETFFKDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATIL 633
+P G R + E F +D + +E + A+ +G D++++ ++
Sbjct: 127 GIPLPAGLRLSSRLPEPIFTPALKND-RGHDENVPEAEVRRR---LGDAVTDFIKEKSLA 182
Query: 634 IFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRLWPS 774
++ L D K EFG + +++ + DS R WP+
Sbjct: 183 LYRYAAGVAEKAGMILADTKFEFGFVGDEIVLIDEAFTPDSSRYWPA 229
>UniRef50_P27616 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=24; cellular organisms|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Saccharomyces cerevisiae (Baker's yeast)
Length = 306
Score = 36.7 bits (81), Expect = 1.3
Identities = 59/257 (22%), Positives = 104/257 (40%), Gaps = 36/257 (14%)
Frame = +1
Query: 154 LLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKS- 330
L+ GK + +++V G L + DRI+A D + + + K + + + F+ L +
Sbjct: 14 LVARGKVRDIYEV--DAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLSND 71
Query: 331 --------AGIKTAF----VKIAS--------ETAFLSKKCEMIPIEWVTRRLATGSFLK 450
A KT F K++ + + L K ++IP+E + R TGS K
Sbjct: 72 VRNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWK 131
Query: 451 R--NPGV------PEGFRFTPPKQETFFKDDANHDPQWSEEQIISAKFNYNGLLIGRDEV 606
G P+G + + E F + +E I A+ L+G D
Sbjct: 132 EYVKTGTVHGLKQPQGLKESQEFPEPIFTPSTKAEQGEHDENISPAQ---AAELVGGDLS 188
Query: 607 DYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTE-GSIVLAD-VIDSDSWRLWPS-- 774
+ + + ++ + + + D K EFG+D + I+L D V+ DS R W
Sbjct: 189 RRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWNGAS 248
Query: 775 ---GDKRLMVDKQVYRN 816
G+ + DKQ R+
Sbjct: 249 YKVGESQDSYDKQFLRD 265
>UniRef50_Q94IQ2 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=1; Crypthecodinium cohnii|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Crypthecodinium cohnii (Dinoflagellate)
Length = 522
Score = 36.3 bits (80), Expect = 1.8
Identities = 44/207 (21%), Positives = 82/207 (39%), Gaps = 6/207 (2%)
Frame = +1
Query: 163 EGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKSAGIK 342
E K+ +V D+ +++ DR++A D + + + K + + F+ K +
Sbjct: 35 ESKSGKVRDIYFAGKNVVMVTNDRVSAFDFILPNLIPFKGQVLCGISEWAFQETKDI-VP 93
Query: 343 TAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGF--RFTPPKQETFFK- 513
A ++ + + KK + +E++ R GS F P F K
Sbjct: 94 NALIENVDSSVVVQKKMTNLNVEFIVRGYLWGSMAAAYEKGDRTFCGLKVPDGLNRFQKF 153
Query: 514 DDANHDPQWSEEQIISAKFNYNGL--LIGRDEVDYMRKATILIFEILEKAWALRDCALID 687
D+ P E Y + LIG+D + + ++ + R LID
Sbjct: 154 DEPLFTPTTKAEVGHDENMTYAEVEKLIGKDMAKKAKDVAMKLYARGAELMRKRGLILID 213
Query: 688 MKIEFGVDTEGSIVLADVIDS-DSWRL 765
K EFG+D G + + D +++ DS R+
Sbjct: 214 TKYEFGLDEHGVLHVIDEVNTPDSSRM 240
>UniRef50_Q60136 Cluster: Penicillin G acylase precursor (EC
3.5.1.11) (Penicillin G amidase) (Penicillin G
amidohydrolase) [Contains: Penicillin G acylase subunit
alpha; Penicillin G acylase subunit beta]; n=3;
Bacteria|Rep: Penicillin G acylase precursor (EC
3.5.1.11) (Penicillin G amidase) (Penicillin G
amidohydrolase) [Contains: Penicillin G acylase subunit
alpha; Penicillin G acylase subunit beta] - Bacillus
megaterium
Length = 802
Score = 35.9 bits (79), Expect = 2.3
Identities = 18/75 (24%), Positives = 35/75 (46%)
Frame = +1
Query: 397 MIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETFFKDDANHDPQWSEEQIISAKFNY 576
M PI + R + +++ P P GF TPP Q F K D + ++ ++ A++ +
Sbjct: 720 MTPIIEMNRG-SENHYIEMTPTGPSGFNITPPGQIGFVKKDGTISDHYDDQLVMFAEWKF 778
Query: 577 NGLLIGRDEVDYMRK 621
L + +++ K
Sbjct: 779 KPYLFNKKDINKAAK 793
>UniRef50_Q3Z881 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=1; Dehalococcoides ethenogenes 195|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Dehalococcoides ethenogenes (strain 195)
Length = 304
Score = 35.5 bits (78), Expect = 3.1
Identities = 19/82 (23%), Positives = 41/82 (50%), Gaps = 5/82 (6%)
Frame = +1
Query: 586 LIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRL 765
++G++ D + + ++ ++++ + R + D K EFG+D I++ + + DS R
Sbjct: 182 MVGKELADKLAEKSLALYKLGREYARQRGIIIADTKFEFGLDGSELILIDEALTPDSSRF 241
Query: 766 WPS-----GDKRLMVDKQVYRN 816
W G+ + DKQ R+
Sbjct: 242 WDEKTYRVGEAQDSYDKQPVRD 263
>UniRef50_Q9HLC0 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=5; Thermoplasmatales|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Thermoplasma acidophilum
Length = 294
Score = 35.1 bits (77), Expect = 4.1
Identities = 50/227 (22%), Positives = 90/227 (39%), Gaps = 21/227 (9%)
Frame = +1
Query: 151 KLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKS 330
K++ +GK K V+D D + +RI+ D + ++E K +T++ F +
Sbjct: 2 KIIAKGKVKDVYDDGDT---LVFRFSNRISVFDKIIPTEIENKGESLCRTSSFWFRYIGE 58
Query: 331 AGIKTAFVKIASETAFLSKKCEM------------IPIEWVTRRLATGSF---LKRNPGV 465
GIK F+++ +K ++ IP+E++TR GS LK
Sbjct: 59 RGIKNHFIEMIDNRTMRVRKYDVPEKVSPGSSGYVIPLEFITRHYVAGSLYDRLKAGSTK 118
Query: 466 PE--GFRFTPPKQETFFKD--DANHDPQWSEEQI-ISAKFNYNGLLIGRDEVDYMRKATI 630
P G P E + + ++ + I +GL R+E +R+ +
Sbjct: 119 PADIGLNHFPDYGEKLPSPVFEVTTKREKTDRLLDIDEALEISGLT--REEYAEIRETIL 176
Query: 631 LIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVI-DSDSWRLW 768
I E++E+ R D K E + E ++ D +D R W
Sbjct: 177 KIDEMMEQEVGKRGLIHADGKKEVALGKEREPIIVDTFGTADEDRFW 223
>UniRef50_A7TI33 Cluster: Putative uncharacterized protein; n=1;
Vanderwaltozyma polyspora DSM 70294|Rep: Putative
uncharacterized protein - Vanderwaltozyma polyspora DSM
70294
Length = 428
Score = 34.7 bits (76), Expect = 5.4
Identities = 18/55 (32%), Positives = 28/55 (50%)
Frame = +1
Query: 133 GQYKLGKLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQ 297
G+ K K L+E ++ +VP GYC + K + G G+ +H L +I NQ
Sbjct: 8 GKEKRPKFLLEFSINELINVPQSTGYCYV--KWSLKDGTGISSHRLSTVESIDNQ 60
>UniRef50_Q9HYC1 Cluster: Putative uncharacterized protein; n=2;
Pseudomonas aeruginosa|Rep: Putative uncharacterized
protein - Pseudomonas aeruginosa
Length = 232
Score = 33.9 bits (74), Expect = 9.5
Identities = 17/73 (23%), Positives = 37/73 (50%)
Frame = +1
Query: 115 SHPKQVGQYKLGKLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISN 294
S P + ++ L+ +T+++++VP++PG C A DG A++L+ +
Sbjct: 46 SKPTENSAQRIKDLIARFRTRELYEVPNEPGICFPYG---FIADDGKTAYELKNSLRFTR 102
Query: 295 QTNAKVFEILKSA 333
N +F +L ++
Sbjct: 103 TPNV-IFSLLTAS 114
>UniRef50_P46970 Cluster: Nonsense-mediated mRNA decay protein 5;
n=6; Saccharomycetales|Rep: Nonsense-mediated mRNA decay
protein 5 - Saccharomyces cerevisiae (Baker's yeast)
Length = 1048
Score = 33.9 bits (74), Expect = 9.5
Identities = 19/54 (35%), Positives = 30/54 (55%)
Frame = +1
Query: 577 NGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLAD 738
N L+ GR+E+ T +IFEI +KA D +L D+++ F + E + L D
Sbjct: 743 NILIYGRNELKKNEFYTKIIFEIYQKAVTAEDNSLDDLRVVFDLSQELVLALDD 796
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 1,077,923,025
Number of Sequences: 1657284
Number of extensions: 21794666
Number of successful extensions: 51659
Number of sequences better than 10.0: 74
Number of HSP's better than 10.0 without gapping: 49472
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 51584
length of database: 575,637,011
effective HSP length: 103
effective length of database: 404,936,759
effective search space used: 136058751024
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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