Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fdpeP14_F_P17.2
(1287 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
X05344-1|CAA28955.1| 412|Homo sapiens cathepsin D protein. 236 1e-61
M63138-1|AAA51922.1| 412|Homo sapiens cathepsin D protein. 236 1e-61
M11233-1|AAB59529.1| 412|Homo sapiens CTSD protein. 236 1e-61
CR456947-1|CAG33228.1| 412|Homo sapiens CTSD protein. 236 1e-61
BT020155-1|AAV38957.1| 412|Homo sapiens cathepsin D (lysosomal ... 236 1e-61
BT006910-1|AAP35556.1| 412|Homo sapiens cathepsin D (lysosomal ... 236 1e-61
BC016320-1|AAH16320.1| 412|Homo sapiens cathepsin D protein. 236 1e-61
BC017842-1|AAH17842.1| 420|Homo sapiens napsin A aspartic pepti... 207 8e-53
AF200345-1|AAF17081.1| 420|Homo sapiens aspartyl protease 4 pro... 206 1e-52
AF098484-1|AAD13215.1| 420|Homo sapiens napsin 1 precursor prot... 206 1e-52
AF090386-1|AAD04917.1| 420|Homo sapiens napsin A protein. 206 1e-52
M84424-1|AAA52300.1| 396|Homo sapiens cathepsin E protein. 192 2e-48
J05036-1|AAA52130.1| 396|Homo sapiens CTSE protein. 192 2e-48
BX571818-5|CAH73265.1| 363|Homo sapiens cathepsin E protein. 192 2e-48
BX571818-4|CAH73264.1| 396|Homo sapiens cathepsin E protein. 192 2e-48
BC042537-1|AAH42537.1| 396|Homo sapiens cathepsin E protein. 192 2e-48
AJ250717-1|CAB82850.1| 396|Homo sapiens procathepsin E protein. 192 2e-48
AJ250716-1|CAB82849.1| 363|Homo sapiens cathepsin E, alternativ... 192 2e-48
BC111705-1|AAI11706.1| 464|Homo sapiens NAPSB protein protein. 188 4e-47
AF200344-1|AAF17080.1| 450|Homo sapiens aspartyl protease 3 pro... 188 4e-47
M10152-1|AAD03461.1| 406|Homo sapiens renin protein. 185 3e-46
L00073-1|AAA60363.1| 406|Homo sapiens renin protein. 185 3e-46
CR536498-1|CAG38737.1| 406|Homo sapiens REN protein. 185 3e-46
BC047752-1|AAH47752.1| 406|Homo sapiens renin protein. 185 3e-46
BC033474-1|AAH33474.1| 406|Homo sapiens renin protein. 185 3e-46
AL592146-1|CAI16594.1| 406|Homo sapiens renin protein. 185 3e-46
AL592114-1|CAH71224.1| 406|Homo sapiens renin protein. 185 3e-46
M26901-1|AAA60364.1| 403|Homo sapiens renin protein. 184 5e-46
AY436324-1|AAR03502.1| 403|Homo sapiens renin protein. 184 5e-46
U75272-1|AAB18273.1| 388|Homo sapiens gastricsin protein. 172 3e-42
M23077-1|AAA60063.1| 388|Homo sapiens pepsinogen C protein. 172 3e-42
M18667-1|AAA60062.1| 385|Homo sapiens pepsinogen protein. 172 3e-42
J04443-1|AAA60074.1| 388|Homo sapiens pepsinogen protein. 172 3e-42
BC073740-1|AAH73740.1| 388|Homo sapiens progastricsin (pepsinog... 172 3e-42
AL365205-1|CAI13181.1| 388|Homo sapiens progastricsin (pepsinog... 172 3e-42
BC029055-1|AAH29055.1| 388|Homo sapiens pepsinogen 5, group I (... 171 6e-42
J00287-1|AAA98529.1| 388|Homo sapiens PEP protein. 170 8e-42
M26032-1|AAA60061.1| 388|Homo sapiens pepsinogen A protein. 169 2e-41
X00063-1|CAA24937.1| 300|Homo sapiens protein ( Human kidney mR... 131 5e-30
BC014453-1|AAH14453.1| 518|Homo sapiens beta-site APP-cleaving ... 72 4e-12
AY358927-1|AAQ89286.1| 518|Homo sapiens BACE2 protein. 72 4e-12
AF212252-1|AAG41783.1| 439|Homo sapiens CDA13 protein. 72 4e-12
AF204944-1|AAF26368.1| 518|Homo sapiens transmembrane aspartic ... 72 4e-12
AF200342-1|AAF17078.1| 518|Homo sapiens aspartyl protease 1 pro... 72 4e-12
AF200192-1|AAF13714.1| 518|Homo sapiens memapsin 1 protein. 72 4e-12
AF188277-1|AAF35836.1| 396|Homo sapiens aspartyl protease protein. 72 4e-12
AF188276-1|AAF35835.1| 468|Homo sapiens aspartyl protease protein. 72 4e-12
AF178532-1|AAF29494.1| 518|Homo sapiens aspartyl protease protein. 72 4e-12
AF117892-1|AAD45240.1| 518|Homo sapiens aspartic-like protease ... 72 4e-12
AF050171-1|AAD45963.1| 518|Homo sapiens aspartyl protease protein. 72 4e-12
AK075539-1|BAC11682.1| 423|Homo sapiens protein ( Homo sapiens ... 71 9e-12
DQ007053-1|AAY16982.1| 501|Homo sapiens beta-site APP-cleaving ... 68 9e-11
BC065492-1|AAH65492.1| 501|Homo sapiens beta-site APP-cleaving ... 68 9e-11
AF204943-1|AAF26367.1| 501|Homo sapiens transmembrane aspartic ... 68 9e-11
AF201468-1|AAF18982.1| 501|Homo sapiens APP beta-secretase prot... 68 9e-11
AF200343-1|AAF17079.1| 501|Homo sapiens aspartyl protease 2 pro... 68 9e-11
AF200193-1|AAF13715.1| 488|Homo sapiens memapsin 2 protein. 68 9e-11
AF190725-1|AAF04142.1| 501|Homo sapiens beta-site APP cleaving ... 68 9e-11
AB032975-1|BAA86463.2| 532|Homo sapiens KIAA1149 protein protein. 68 9e-11
BC036084-1|AAH36084.1| 501|Homo sapiens beta-site APP-cleaving ... 65 5e-10
AL365205-2|CAI95135.1| 140|Homo sapiens progastricsin (pepsinog... 60 1e-08
BC042578-1|AAH42578.1| 104|Homo sapiens PGC protein protein. 60 2e-08
AF338816-1|AAK38374.1| 476|Homo sapiens beta-site APP cleaving ... 56 2e-07
AB050436-1|BAB40931.1| 476|Homo sapiens beta-site APP cleaving ... 56 2e-07
AL163285-1|CAB90554.1| 415|Homo sapiens beta-site APP-cleaving ... 56 4e-07
AB050438-1|BAB40933.1| 432|Homo sapiens beta-site APP cleaving ... 42 0.004
AF338817-1|AAK38375.1| 457|Homo sapiens beta-site APP cleaving ... 42 0.005
AB050437-1|BAB40932.1| 457|Homo sapiens beta-site APP cleaving ... 42 0.005
AB177847-1|BAD66825.1| 396|Homo sapiens KIAA1149 splice variant... 42 0.006
AL365205-3|CAM16152.1| 86|Homo sapiens progastricsin (pepsinog... 39 0.045
AB089958-1|BAC81826.1| 127|Homo sapiens beta-site APP cleaving ... 37 0.18
M11437-2|AAB59550.1| 644|Homo sapiens kininogen protein. 33 2.2
AF141344-1|AAG49447.1| 119|Homo sapiens LYST-interacting protei... 32 3.9
AK055141-1|BAB70862.1| 260|Homo sapiens protein ( Homo sapiens ... 32 5.2
>X05344-1|CAA28955.1| 412|Homo sapiens cathepsin D protein.
Length = 412
Score = 236 bits (577), Expect = 1e-61
Identities = 125/227 (55%), Positives = 152/227 (66%), Gaps = 23/227 (10%)
Frame = +3
Query: 198 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 344
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 345 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 524
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 525 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 671
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 672 VAAKFDGILGMAFSTIAVDHVTPVFDNMVAQGLV-QPVFSFYLNREP 809
+AAKFDGILGMA+ I+V++V PVFDN++ Q LV Q +FSFYL+R+P
Sbjct: 191 IAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDP 237
Score = 61.7 bits (143), Expect = 6e-09
Identities = 29/78 (37%), Positives = 41/78 (52%), Gaps = 1/78 (1%)
Frame = +1
Query: 805 NPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHMDSVNVNAS-RFCAQGCSAIAD 981
+P A +D +Y+G L + + R YW+ H+D V V + C +GC AI D
Sbjct: 236 DPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVD 295
Query: 982 TGTSLIAGPSXEVEALXR 1035
TGTSL+ GP EV L +
Sbjct: 296 TGTSLMVGPVDEVRELQK 313
>M63138-1|AAA51922.1| 412|Homo sapiens cathepsin D protein.
Length = 412
Score = 236 bits (577), Expect = 1e-61
Identities = 125/227 (55%), Positives = 152/227 (66%), Gaps = 23/227 (10%)
Frame = +3
Query: 198 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 344
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 345 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 524
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 525 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 671
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 672 VAAKFDGILGMAFSTIAVDHVTPVFDNMVAQGLV-QPVFSFYLNREP 809
+AAKFDGILGMA+ I+V++V PVFDN++ Q LV Q +FSFYL+R+P
Sbjct: 191 IAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDP 237
Score = 61.7 bits (143), Expect = 6e-09
Identities = 29/78 (37%), Positives = 41/78 (52%), Gaps = 1/78 (1%)
Frame = +1
Query: 805 NPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHMDSVNVNAS-RFCAQGCSAIAD 981
+P A +D +Y+G L + + R YW+ H+D V V + C +GC AI D
Sbjct: 236 DPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVD 295
Query: 982 TGTSLIAGPSXEVEALXR 1035
TGTSL+ GP EV L +
Sbjct: 296 TGTSLMVGPVDEVRELQK 313
>M11233-1|AAB59529.1| 412|Homo sapiens CTSD protein.
Length = 412
Score = 236 bits (577), Expect = 1e-61
Identities = 125/227 (55%), Positives = 152/227 (66%), Gaps = 23/227 (10%)
Frame = +3
Query: 198 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 344
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 345 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 524
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 525 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 671
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 672 VAAKFDGILGMAFSTIAVDHVTPVFDNMVAQGLV-QPVFSFYLNREP 809
+AAKFDGILGMA+ I+V++V PVFDN++ Q LV Q +FSFYL+R+P
Sbjct: 191 IAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDP 237
Score = 61.7 bits (143), Expect = 6e-09
Identities = 29/78 (37%), Positives = 41/78 (52%), Gaps = 1/78 (1%)
Frame = +1
Query: 805 NPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHMDSVNVNAS-RFCAQGCSAIAD 981
+P A +D +Y+G L + + R YW+ H+D V V + C +GC AI D
Sbjct: 236 DPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVD 295
Query: 982 TGTSLIAGPSXEVEALXR 1035
TGTSL+ GP EV L +
Sbjct: 296 TGTSLMVGPVDEVRELQK 313
>CR456947-1|CAG33228.1| 412|Homo sapiens CTSD protein.
Length = 412
Score = 236 bits (577), Expect = 1e-61
Identities = 125/227 (55%), Positives = 152/227 (66%), Gaps = 23/227 (10%)
Frame = +3
Query: 198 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 344
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 345 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 524
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 525 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 671
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 672 VAAKFDGILGMAFSTIAVDHVTPVFDNMVAQGLV-QPVFSFYLNREP 809
+AAKFDGILGMA+ I+V++V PVFDN++ Q LV Q +FSFYL+R+P
Sbjct: 191 IAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDP 237
Score = 61.7 bits (143), Expect = 6e-09
Identities = 29/78 (37%), Positives = 41/78 (52%), Gaps = 1/78 (1%)
Frame = +1
Query: 805 NPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHMDSVNVNAS-RFCAQGCSAIAD 981
+P A +D +Y+G L + + R YW+ H+D V V + C +GC AI D
Sbjct: 236 DPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVD 295
Query: 982 TGTSLIAGPSXEVEALXR 1035
TGTSL+ GP EV L +
Sbjct: 296 TGTSLMVGPVDEVRELQK 313
>BT020155-1|AAV38957.1| 412|Homo sapiens cathepsin D (lysosomal
aspartyl protease) protein.
Length = 412
Score = 236 bits (577), Expect = 1e-61
Identities = 125/227 (55%), Positives = 152/227 (66%), Gaps = 23/227 (10%)
Frame = +3
Query: 198 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 344
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 345 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 524
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 525 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 671
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 672 VAAKFDGILGMAFSTIAVDHVTPVFDNMVAQGLV-QPVFSFYLNREP 809
+AAKFDGILGMA+ I+V++V PVFDN++ Q LV Q +FSFYL+R+P
Sbjct: 191 IAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDP 237
Score = 61.7 bits (143), Expect = 6e-09
Identities = 29/78 (37%), Positives = 41/78 (52%), Gaps = 1/78 (1%)
Frame = +1
Query: 805 NPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHMDSVNVNAS-RFCAQGCSAIAD 981
+P A +D +Y+G L + + R YW+ H+D V V + C +GC AI D
Sbjct: 236 DPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVD 295
Query: 982 TGTSLIAGPSXEVEALXR 1035
TGTSL+ GP EV L +
Sbjct: 296 TGTSLMVGPVDEVRELQK 313
>BT006910-1|AAP35556.1| 412|Homo sapiens cathepsin D (lysosomal
aspartyl protease) protein.
Length = 412
Score = 236 bits (577), Expect = 1e-61
Identities = 125/227 (55%), Positives = 152/227 (66%), Gaps = 23/227 (10%)
Frame = +3
Query: 198 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 344
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 345 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 524
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 525 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 671
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 672 VAAKFDGILGMAFSTIAVDHVTPVFDNMVAQGLV-QPVFSFYLNREP 809
+AAKFDGILGMA+ I+V++V PVFDN++ Q LV Q +FSFYL+R+P
Sbjct: 191 IAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDP 237
Score = 61.7 bits (143), Expect = 6e-09
Identities = 29/78 (37%), Positives = 41/78 (52%), Gaps = 1/78 (1%)
Frame = +1
Query: 805 NPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHMDSVNVNAS-RFCAQGCSAIAD 981
+P A +D +Y+G L + + R YW+ H+D V V + C +GC AI D
Sbjct: 236 DPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVD 295
Query: 982 TGTSLIAGPSXEVEALXR 1035
TGTSL+ GP EV L +
Sbjct: 296 TGTSLMVGPVDEVRELQK 313
>BC016320-1|AAH16320.1| 412|Homo sapiens cathepsin D protein.
Length = 412
Score = 236 bits (577), Expect = 1e-61
Identities = 125/227 (55%), Positives = 152/227 (66%), Gaps = 23/227 (10%)
Frame = +3
Query: 198 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 344
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 345 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 524
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 525 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 671
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 672 VAAKFDGILGMAFSTIAVDHVTPVFDNMVAQGLV-QPVFSFYLNREP 809
+AAKFDGILGMA+ I+V++V PVFDN++ Q LV Q +FSFYL+R+P
Sbjct: 191 IAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDP 237
Score = 61.7 bits (143), Expect = 6e-09
Identities = 29/78 (37%), Positives = 41/78 (52%), Gaps = 1/78 (1%)
Frame = +1
Query: 805 NPGATTXXXXXXXXSDPAHYRGDLVRVPLLRDTYWEFHMDSVNVNAS-RFCAQGCSAIAD 981
+P A +D +Y+G L + + R YW+ H+D V V + C +GC AI D
Sbjct: 236 DPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVD 295
Query: 982 TGTSLIAGPSXEVEALXR 1035
TGTSL+ GP EV L +
Sbjct: 296 TGTSLMVGPVDEVRELQK 313
>BC017842-1|AAH17842.1| 420|Homo sapiens napsin A aspartic
peptidase protein.
Length = 420
Score = 207 bits (505), Expect = 8e-53
Identities = 101/207 (48%), Positives = 137/207 (66%), Gaps = 6/207 (2%)
Frame = +3
Query: 207 IASSVMALYRVPLHRMKTARTHFHEVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 371
+ S L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 19 VEPSGATLIRIPLHRVQPGRRTLNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 372 YGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFA 551
+G I +GTPPQ+F V FDTGSSNLWVPS++CH+ ++ C LH+++D + S ++ ANGT+FA
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFA 138
Query: 552 IQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDH 731
IQYG+G + G LS D +T+GG+K F EA+ EP L F A FDGILG+ F ++V+
Sbjct: 139 IQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHFDGILGLGFPILSVEG 198
Query: 732 VTPVFDNMVAQGLV-QPVFSFYLNREP 809
V P D +V QGL+ +PVFSFYLNR+P
Sbjct: 199 VRPPMDVLVEQGLLDKPVFSFYLNRDP 225
Score = 71.3 bits (167), Expect = 7e-12
Identities = 33/62 (53%), Positives = 40/62 (64%), Gaps = 1/62 (1%)
Frame = +1
Query: 847 SDPAHYRGDLVRVPLLRDTYWEFHMDSVNVNAS-RFCAQGCSAIADTGTSLIAGPSXEVE 1023
SDPAHY L VP+ YW+ HM+ V V CA+GC+AI DTGTSLI GP+ E+
Sbjct: 238 SDPAHYIPPLTFVPVTVPAYWQIHMERVKVGPGLTLCAKGCAAILDTGTSLITGPTEEIR 297
Query: 1024 AL 1029
AL
Sbjct: 298 AL 299
>AF200345-1|AAF17081.1| 420|Homo sapiens aspartyl protease 4
protein.
Length = 420
Score = 206 bits (504), Expect = 1e-52
Identities = 101/207 (48%), Positives = 137/207 (66%), Gaps = 6/207 (2%)
Frame = +3
Query: 207 IASSVMALYRVPLHRMKTARTHFHEVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 371
+ S L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 19 VEPSGATLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 372 YGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFA 551
+G I +GTPPQ+F V FDTGSSNLWVPS++CH+ ++ C LH+++D + S ++ ANGT+FA
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFA 138
Query: 552 IQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDH 731
IQYG+G + G LS D +T+GG+K F EA+ EP L F A FDGILG+ F ++V+
Sbjct: 139 IQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHFDGILGLGFPILSVEG 198
Query: 732 VTPVFDNMVAQGLV-QPVFSFYLNREP 809
V P D +V QGL+ +PVFSFYLNR+P
Sbjct: 199 VRPPMDVLVEQGLLDKPVFSFYLNRDP 225
Score = 71.3 bits (167), Expect = 7e-12
Identities = 33/62 (53%), Positives = 40/62 (64%), Gaps = 1/62 (1%)
Frame = +1
Query: 847 SDPAHYRGDLVRVPLLRDTYWEFHMDSVNVNAS-RFCAQGCSAIADTGTSLIAGPSXEVE 1023
SDPAHY L VP+ YW+ HM+ V V CA+GC+AI DTGTSLI GP+ E+
Sbjct: 238 SDPAHYIPPLTFVPVTVPAYWQIHMERVKVGPGLTLCAKGCAAILDTGTSLITGPTEEIR 297
Query: 1024 AL 1029
AL
Sbjct: 298 AL 299
>AF098484-1|AAD13215.1| 420|Homo sapiens napsin 1 precursor
protein.
Length = 420
Score = 206 bits (504), Expect = 1e-52
Identities = 101/207 (48%), Positives = 137/207 (66%), Gaps = 6/207 (2%)
Frame = +3
Query: 207 IASSVMALYRVPLHRMKTARTHFHEVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 371
+ S L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 19 VEPSGATLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 372 YGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFA 551
+G I +GTPPQ+F V FDTGSSNLWVPS++CH+ ++ C LH+++D + S ++ ANGT+FA
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFA 138
Query: 552 IQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDH 731
IQYG+G + G LS D +T+GG+K F EA+ EP L F A FDGILG+ F ++V+
Sbjct: 139 IQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHFDGILGLGFPILSVEG 198
Query: 732 VTPVFDNMVAQGLV-QPVFSFYLNREP 809
V P D +V QGL+ +PVFSFYLNR+P
Sbjct: 199 VRPPMDVLVEQGLLDKPVFSFYLNRDP 225
Score = 71.3 bits (167), Expect = 7e-12
Identities = 33/62 (53%), Positives = 40/62 (64%), Gaps = 1/62 (1%)
Frame = +1
Query: 847 SDPAHYRGDLVRVPLLRDTYWEFHMDSVNVNAS-RFCAQGCSAIADTGTSLIAGPSXEVE 1023
SDPAHY L VP+ YW+ HM+ V V CA+GC+AI DTGTSLI GP+ E+
Sbjct: 238 SDPAHYIPPLTFVPVTVPAYWQIHMERVKVGPGLTLCAKGCAAILDTGTSLITGPTEEIR 297
Query: 1024 AL 1029
AL
Sbjct: 298 AL 299
>AF090386-1|AAD04917.1| 420|Homo sapiens napsin A protein.
Length = 420
Score = 206 bits (504), Expect = 1e-52
Identities = 101/207 (48%), Positives = 137/207 (66%), Gaps = 6/207 (2%)
Frame = +3
Query: 207 IASSVMALYRVPLHRMKTARTHFHEVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 371
+ S L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 19 VEPSGATLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 372 YGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFA 551
+G I +GTPPQ+F V FDTGSSNLWVPS++CH+ ++ C LH+++D + S ++ ANGT+FA
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFA 138
Query: 552 IQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDH 731
IQYG+G + G LS D +T+GG+K F EA+ EP L F A FDGILG+ F ++V+
Sbjct: 139 IQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHFDGILGLGFPILSVEG 198
Query: 732 VTPVFDNMVAQGLV-QPVFSFYLNREP 809
V P D +V QGL+ +PVFSFYLNR+P
Sbjct: 199 VRPPMDVLVEQGLLDKPVFSFYLNRDP 225
Score = 71.3 bits (167), Expect = 7e-12
Identities = 33/62 (53%), Positives = 40/62 (64%), Gaps = 1/62 (1%)
Frame = +1
Query: 847 SDPAHYRGDLVRVPLLRDTYWEFHMDSVNVNAS-RFCAQGCSAIADTGTSLIAGPSXEVE 1023
SDPAHY L VP+ YW+ HM+ V V CA+GC+AI DTGTSLI GP+ E+
Sbjct: 238 SDPAHYIPPLTFVPVTVPAYWQIHMERVKVGPGLTLCAKGCAAILDTGTSLITGPTEEIR 297
Query: 1024 AL 1029
AL
Sbjct: 298 AL 299
>M84424-1|AAA52300.1| 396|Homo sapiens cathepsin E protein.
Length = 396
Score = 192 bits (468), Expect = 2e-48
Identities = 103/220 (46%), Positives = 139/220 (63%), Gaps = 11/220 (5%)
Frame = +3
Query: 189 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 338
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 339 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 518
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 519 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGIL 698
TY G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGIL
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 185
Query: 699 GMAFSTIAVDHVTPVFDNMVAQGLVQ-PVFSFYLNREPRG 815
G+ + ++AV VTPVFDNM+AQ LV P+FS Y++ P G
Sbjct: 186 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEG 225
Score = 66.1 bits (154), Expect = 3e-10
Identities = 27/61 (44%), Positives = 41/61 (67%), Gaps = 1/61 (1%)
Frame = +1
Query: 850 DPAHYRGDLVRVPLLRDTYWEFHMDSVNVNAS-RFCAQGCSAIADTGTSLIAGPSXEVEA 1026
D +H+ G L VP+ + YW+ +D++ V + FC++GC AI DTGTSLI GPS +++
Sbjct: 237 DHSHFSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQ 296
Query: 1027 L 1029
L
Sbjct: 297 L 297
>J05036-1|AAA52130.1| 396|Homo sapiens CTSE protein.
Length = 396
Score = 192 bits (468), Expect = 2e-48
Identities = 103/220 (46%), Positives = 139/220 (63%), Gaps = 11/220 (5%)
Frame = +3
Query: 189 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 338
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 339 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 518
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 519 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGIL 698
TY G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGIL
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 185
Query: 699 GMAFSTIAVDHVTPVFDNMVAQGLVQ-PVFSFYLNREPRG 815
G+ + ++AV VTPVFDNM+AQ LV P+FS Y++ P G
Sbjct: 186 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEG 225
Score = 66.1 bits (154), Expect = 3e-10
Identities = 27/61 (44%), Positives = 41/61 (67%), Gaps = 1/61 (1%)
Frame = +1
Query: 850 DPAHYRGDLVRVPLLRDTYWEFHMDSVNVNAS-RFCAQGCSAIADTGTSLIAGPSXEVEA 1026
D +H+ G L VP+ + YW+ +D++ V + FC++GC AI DTGTSLI GPS +++
Sbjct: 237 DHSHFSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQ 296
Query: 1027 L 1029
L
Sbjct: 297 L 297
>BX571818-5|CAH73265.1| 363|Homo sapiens cathepsin E protein.
Length = 363
Score = 192 bits (468), Expect = 2e-48
Identities = 103/220 (46%), Positives = 139/220 (63%), Gaps = 11/220 (5%)
Frame = +3
Query: 189 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 338
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 339 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 518
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 519 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGIL 698
TY G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGIL
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 185
Query: 699 GMAFSTIAVDHVTPVFDNMVAQGLVQ-PVFSFYLNREPRG 815
G+ + ++AV VTPVFDNM+AQ LV P+FS Y++ P G
Sbjct: 186 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEG 225
>BX571818-4|CAH73264.1| 396|Homo sapiens cathepsin E protein.
Length = 396
Score = 192 bits (468), Expect = 2e-48
Identities = 103/220 (46%), Positives = 139/220 (63%), Gaps = 11/220 (5%)
Frame = +3
Query: 189 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 338
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 339 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 518
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 519 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGIL 698
TY G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGIL
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 185
Query: 699 GMAFSTIAVDHVTPVFDNMVAQGLVQ-PVFSFYLNREPRG 815
G+ + ++AV VTPVFDNM+AQ LV P+FS Y++ P G
Sbjct: 186 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEG 225
Score = 66.1 bits (154), Expect = 3e-10
Identities = 27/61 (44%), Positives = 41/61 (67%), Gaps = 1/61 (1%)
Frame = +1
Query: 850 DPAHYRGDLVRVPLLRDTYWEFHMDSVNVNAS-RFCAQGCSAIADTGTSLIAGPSXEVEA 1026
D +H+ G L VP+ + YW+ +D++ V + FC++GC AI DTGTSLI GPS +++
Sbjct: 237 DHSHFSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQ 296
Query: 1027 L 1029
L
Sbjct: 297 L 297
>BC042537-1|AAH42537.1| 396|Homo sapiens cathepsin E protein.
Length = 396
Score = 192 bits (468), Expect = 2e-48
Identities = 103/220 (46%), Positives = 139/220 (63%), Gaps = 11/220 (5%)
Frame = +3
Query: 189 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 338
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 339 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 518
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 519 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGIL 698
TY G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGIL
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 185
Query: 699 GMAFSTIAVDHVTPVFDNMVAQGLVQ-PVFSFYLNREPRG 815
G+ + ++AV VTPVFDNM+AQ LV P+FS Y++ P G
Sbjct: 186 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEG 225
Score = 66.1 bits (154), Expect = 3e-10
Identities = 27/61 (44%), Positives = 41/61 (67%), Gaps = 1/61 (1%)
Frame = +1
Query: 850 DPAHYRGDLVRVPLLRDTYWEFHMDSVNVNAS-RFCAQGCSAIADTGTSLIAGPSXEVEA 1026
D +H+ G L VP+ + YW+ +D++ V + FC++GC AI DTGTSLI GPS +++
Sbjct: 237 DHSHFSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQ 296
Query: 1027 L 1029
L
Sbjct: 297 L 297
>AJ250717-1|CAB82850.1| 396|Homo sapiens procathepsin E protein.
Length = 396
Score = 192 bits (468), Expect = 2e-48
Identities = 103/220 (46%), Positives = 139/220 (63%), Gaps = 11/220 (5%)
Frame = +3
Query: 189 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 338
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 339 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 518
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 519 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGIL 698
TY G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGIL
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 185
Query: 699 GMAFSTIAVDHVTPVFDNMVAQGLVQ-PVFSFYLNREPRG 815
G+ + ++AV VTPVFDNM+AQ LV P+FS Y++ P G
Sbjct: 186 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEG 225
Score = 66.1 bits (154), Expect = 3e-10
Identities = 27/61 (44%), Positives = 41/61 (67%), Gaps = 1/61 (1%)
Frame = +1
Query: 850 DPAHYRGDLVRVPLLRDTYWEFHMDSVNVNAS-RFCAQGCSAIADTGTSLIAGPSXEVEA 1026
D +H+ G L VP+ + YW+ +D++ V + FC++GC AI DTGTSLI GPS +++
Sbjct: 237 DHSHFSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQ 296
Query: 1027 L 1029
L
Sbjct: 297 L 297
>AJ250716-1|CAB82849.1| 363|Homo sapiens cathepsin E, alternative
protein.
Length = 363
Score = 192 bits (468), Expect = 2e-48
Identities = 103/220 (46%), Positives = 139/220 (63%), Gaps = 11/220 (5%)
Frame = +3
Query: 189 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 338
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 339 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 518
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 519 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGIL 698
TY G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGIL
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 185
Query: 699 GMAFSTIAVDHVTPVFDNMVAQGLVQ-PVFSFYLNREPRG 815
G+ + ++AV VTPVFDNM+AQ LV P+FS Y++ P G
Sbjct: 186 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEG 225
>BC111705-1|AAI11706.1| 464|Homo sapiens NAPSB protein protein.
Length = 464
Score = 188 bits (458), Expect = 4e-47
Identities = 91/200 (45%), Positives = 130/200 (65%), Gaps = 6/200 (3%)
Frame = +3
Query: 228 LYRVPLHRMKTARTHFHEV---GTELELLRLKYDVTGPSPE--PLSNYLDAQYYGVISIG 392
L R+PL ++ R + + G EL +L G P PLS +LDAQY+G I +G
Sbjct: 22 LIRIPLRQVHPGRRTLNLLRGWGKPAELPKLGAPSPGDKPASVPLSKFLDAQYFGEIGLG 81
Query: 393 TPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGS 572
TPPQ+F V FDTGSSNLWVPS++CH+ ++ C H++++ S ++ +GT+FAIQYG+G
Sbjct: 82 TPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWFHHRFNPNASSSFKPSGTKFAIQYGTGR 141
Query: 573 LSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPVFDN 752
+ G LS D +T+GG+K F EA+ E L F ++ DGILG+ F ++V+ V P D
Sbjct: 142 VDGILSEDKLTIGGIKGASVIFGEALWESSLVFTVSRPDGILGLGFPILSVEGVRPPLDV 201
Query: 753 MVAQGLV-QPVFSFYLNREP 809
+V QGL+ +PVFSFY NR+P
Sbjct: 202 LVEQGLLDKPVFSFYFNRDP 221
Score = 70.1 bits (164), Expect = 2e-11
Identities = 32/62 (51%), Positives = 40/62 (64%), Gaps = 1/62 (1%)
Frame = +1
Query: 847 SDPAHYRGDLVRVPLLRDTYWEFHMDSVNVNAS-RFCAQGCSAIADTGTSLIAGPSXEVE 1023
SDPAHY L VP+ YW+ HM+ V V + CAQGC+AI DTGT +I GP+ E+
Sbjct: 234 SDPAHYIPPLTFVPVTVPAYWQIHMERVKVGSRLTLCAQGCAAILDTGTPVIVGPTEEIR 293
Query: 1024 AL 1029
AL
Sbjct: 294 AL 295
>AF200344-1|AAF17080.1| 450|Homo sapiens aspartyl protease 3
protein.
Length = 450
Score = 188 bits (458), Expect = 4e-47
Identities = 91/200 (45%), Positives = 130/200 (65%), Gaps = 6/200 (3%)
Frame = +3
Query: 228 LYRVPLHRMKTARTHFHEV---GTELELLRLKYDVTGPSPE--PLSNYLDAQYYGVISIG 392
L R+PL ++ R + + G EL +L G P PLS +LDAQY+G I +G
Sbjct: 26 LIRIPLRQVHPGRRTLNLLRGWGKPAELPKLGAPSPGDKPASVPLSKFLDAQYFGEIGLG 85
Query: 393 TPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGS 572
TPPQ+F V FDTGSSNLWVPS++CH+ ++ C H++++ S ++ +GT+FAIQYG+G
Sbjct: 86 TPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWFHHRFNPNASSSFKPSGTKFAIQYGTGR 145
Query: 573 LSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPVFDN 752
+ G LS D +T+GG+K F EA+ E L F ++ DGILG+ F ++V+ V P D
Sbjct: 146 VDGILSEDKLTIGGIKGASVIFGEALWESSLVFTVSRPDGILGLGFPILSVEGVRPPLDV 205
Query: 753 MVAQGLV-QPVFSFYLNREP 809
+V QGL+ +PVFSFY NR+P
Sbjct: 206 LVEQGLLDKPVFSFYFNRDP 225
Score = 70.1 bits (164), Expect = 2e-11
Identities = 32/62 (51%), Positives = 40/62 (64%), Gaps = 1/62 (1%)
Frame = +1
Query: 847 SDPAHYRGDLVRVPLLRDTYWEFHMDSVNVNAS-RFCAQGCSAIADTGTSLIAGPSXEVE 1023
SDPAHY L VP+ YW+ HM+ V V + CAQGC+AI DTGT +I GP+ E+
Sbjct: 238 SDPAHYIPPLTFVPVTVPAYWQIHMERVKVGSRLTLCAQGCAAILDTGTPVIVGPTEEIR 297
Query: 1024 AL 1029
AL
Sbjct: 298 AL 299
>M10152-1|AAD03461.1| 406|Homo sapiens renin protein.
Length = 406
Score = 185 bits (451), Expect = 3e-46
Identities = 84/155 (54%), Positives = 111/155 (71%), Gaps = 1/155 (0%)
Frame = +3
Query: 345 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 524
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 525 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 704
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 705 AFSTIAVDHVTPVFDNMVAQG-LVQPVFSFYLNRE 806
F A+ VTP+FDN+++QG L + VFSFY NR+
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRD 231
Score = 55.6 bits (128), Expect = 4e-07
Identities = 26/72 (36%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Frame = +1
Query: 847 SDPAHYRGDLVRVPLLRDTYWEFHMDSVNVNASRF-CAQGCSAIADTGTSLIAGPSXEVE 1023
SDP HY G+ + L++ W+ M V+V +S C GC A+ DTG S I+G + +E
Sbjct: 247 SDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIE 306
Query: 1024 ALXRGXAXGHRL 1059
L RL
Sbjct: 307 KLMEALGAKKRL 318
>L00073-1|AAA60363.1| 406|Homo sapiens renin protein.
Length = 406
Score = 185 bits (451), Expect = 3e-46
Identities = 84/155 (54%), Positives = 111/155 (71%), Gaps = 1/155 (0%)
Frame = +3
Query: 345 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 524
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 525 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 704
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 705 AFSTIAVDHVTPVFDNMVAQG-LVQPVFSFYLNRE 806
F A+ VTP+FDN+++QG L + VFSFY NR+
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRD 231
Score = 55.6 bits (128), Expect = 4e-07
Identities = 26/72 (36%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Frame = +1
Query: 847 SDPAHYRGDLVRVPLLRDTYWEFHMDSVNVNASRF-CAQGCSAIADTGTSLIAGPSXEVE 1023
SDP HY G+ + L++ W+ M V+V +S C GC A+ DTG S I+G + +E
Sbjct: 247 SDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIE 306
Query: 1024 ALXRGXAXGHRL 1059
L RL
Sbjct: 307 KLMEALGAKKRL 318
>CR536498-1|CAG38737.1| 406|Homo sapiens REN protein.
Length = 406
Score = 185 bits (451), Expect = 3e-46
Identities = 84/155 (54%), Positives = 111/155 (71%), Gaps = 1/155 (0%)
Frame = +3
Query: 345 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 524
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 525 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 704
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 705 AFSTIAVDHVTPVFDNMVAQG-LVQPVFSFYLNRE 806
F A+ VTP+FDN+++QG L + VFSFY NR+
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRD 231
Score = 55.6 bits (128), Expect = 4e-07
Identities = 26/72 (36%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Frame = +1
Query: 847 SDPAHYRGDLVRVPLLRDTYWEFHMDSVNVNASRF-CAQGCSAIADTGTSLIAGPSXEVE 1023
SDP HY G+ + L++ W+ M V+V +S C GC A+ DTG S I+G + +E
Sbjct: 247 SDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIE 306
Query: 1024 ALXRGXAXGHRL 1059
L RL
Sbjct: 307 KLMEALGAKKRL 318
>BC047752-1|AAH47752.1| 406|Homo sapiens renin protein.
Length = 406
Score = 185 bits (451), Expect = 3e-46
Identities = 84/155 (54%), Positives = 111/155 (71%), Gaps = 1/155 (0%)
Frame = +3
Query: 345 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 524
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 525 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 704
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 705 AFSTIAVDHVTPVFDNMVAQG-LVQPVFSFYLNRE 806
F A+ VTP+FDN+++QG L + VFSFY NR+
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRD 231
Score = 55.6 bits (128), Expect = 4e-07
Identities = 26/72 (36%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Frame = +1
Query: 847 SDPAHYRGDLVRVPLLRDTYWEFHMDSVNVNASRF-CAQGCSAIADTGTSLIAGPSXEVE 1023
SDP HY G+ + L++ W+ M V+V +S C GC A+ DTG S I+G + +E
Sbjct: 247 SDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIE 306
Query: 1024 ALXRGXAXGHRL 1059
L RL
Sbjct: 307 KLMEALGAKKRL 318
>BC033474-1|AAH33474.1| 406|Homo sapiens renin protein.
Length = 406
Score = 185 bits (451), Expect = 3e-46
Identities = 84/155 (54%), Positives = 111/155 (71%), Gaps = 1/155 (0%)
Frame = +3
Query: 345 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 524
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 525 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 704
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 705 AFSTIAVDHVTPVFDNMVAQG-LVQPVFSFYLNRE 806
F A+ VTP+FDN+++QG L + VFSFY NR+
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRD 231
Score = 55.6 bits (128), Expect = 4e-07
Identities = 26/72 (36%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Frame = +1
Query: 847 SDPAHYRGDLVRVPLLRDTYWEFHMDSVNVNASRF-CAQGCSAIADTGTSLIAGPSXEVE 1023
SDP HY G+ + L++ W+ M V+V +S C GC A+ DTG S I+G + +E
Sbjct: 247 SDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIE 306
Query: 1024 ALXRGXAXGHRL 1059
L RL
Sbjct: 307 KLMEALGAKKRL 318
>AL592146-1|CAI16594.1| 406|Homo sapiens renin protein.
Length = 406
Score = 185 bits (451), Expect = 3e-46
Identities = 84/155 (54%), Positives = 111/155 (71%), Gaps = 1/155 (0%)
Frame = +3
Query: 345 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 524
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 525 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 704
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 705 AFSTIAVDHVTPVFDNMVAQG-LVQPVFSFYLNRE 806
F A+ VTP+FDN+++QG L + VFSFY NR+
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRD 231
Score = 55.6 bits (128), Expect = 4e-07
Identities = 26/72 (36%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Frame = +1
Query: 847 SDPAHYRGDLVRVPLLRDTYWEFHMDSVNVNASRF-CAQGCSAIADTGTSLIAGPSXEVE 1023
SDP HY G+ + L++ W+ M V+V +S C GC A+ DTG S I+G + +E
Sbjct: 247 SDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIE 306
Query: 1024 ALXRGXAXGHRL 1059
L RL
Sbjct: 307 KLMEALGAKKRL 318
>AL592114-1|CAH71224.1| 406|Homo sapiens renin protein.
Length = 406
Score = 185 bits (451), Expect = 3e-46
Identities = 84/155 (54%), Positives = 111/155 (71%), Gaps = 1/155 (0%)
Frame = +3
Query: 345 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 524
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 525 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 704
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 705 AFSTIAVDHVTPVFDNMVAQG-LVQPVFSFYLNRE 806
F A+ VTP+FDN+++QG L + VFSFY NR+
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRD 231
Score = 55.6 bits (128), Expect = 4e-07
Identities = 26/72 (36%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Frame = +1
Query: 847 SDPAHYRGDLVRVPLLRDTYWEFHMDSVNVNASRF-CAQGCSAIADTGTSLIAGPSXEVE 1023
SDP HY G+ + L++ W+ M V+V +S C GC A+ DTG S I+G + +E
Sbjct: 247 SDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIE 306
Query: 1024 ALXRGXAXGHRL 1059
L RL
Sbjct: 307 KLMEALGAKKRL 318
>M26901-1|AAA60364.1| 403|Homo sapiens renin protein.
Length = 403
Score = 184 bits (449), Expect = 5e-46
Identities = 84/154 (54%), Positives = 110/154 (71%), Gaps = 1/154 (0%)
Frame = +3
Query: 345 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 524
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 525 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 704
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAQFDGVVGM 196
Query: 705 AFSTIAVDHVTPVFDNMVAQG-LVQPVFSFYLNR 803
F A+ VTP+FDN+++QG L + VFSFY NR
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNR 230
Score = 54.0 bits (124), Expect = 1e-06
Identities = 26/72 (36%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Frame = +1
Query: 847 SDPAHYRGDLVRVPLLRDTYWEFHMDSVNVNASR-FCAQGCSAIADTGTSLIAGPSXEVE 1023
SDP HY G+ + L++ W+ M V+V +S C GC A+ DTG S I+G + +E
Sbjct: 244 SDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSCIE 303
Query: 1024 ALXRGXAXGHRL 1059
L RL
Sbjct: 304 KLMEALGAKKRL 315
>AY436324-1|AAR03502.1| 403|Homo sapiens renin protein.
Length = 403
Score = 184 bits (449), Expect = 5e-46
Identities = 84/154 (54%), Positives = 110/154 (71%), Gaps = 1/154 (0%)
Frame = +3
Query: 345 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 524
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 525 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 704
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 705 AFSTIAVDHVTPVFDNMVAQG-LVQPVFSFYLNR 803
F A+ VTP+FDN+++QG L + VFSFY NR
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNR 230
Score = 55.6 bits (128), Expect = 4e-07
Identities = 26/72 (36%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Frame = +1
Query: 847 SDPAHYRGDLVRVPLLRDTYWEFHMDSVNVNASRF-CAQGCSAIADTGTSLIAGPSXEVE 1023
SDP HY G+ + L++ W+ M V+V +S C GC A+ DTG S I+G + +E
Sbjct: 244 SDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIE 303
Query: 1024 ALXRGXAXGHRL 1059
L RL
Sbjct: 304 KLMEALGAKKRL 315
>U75272-1|AAB18273.1| 388|Homo sapiens gastricsin protein.
Length = 388
Score = 172 bits (418), Expect = 3e-42
Identities = 93/204 (45%), Positives = 127/204 (62%), Gaps = 10/204 (4%)
Frame = +3
Query: 225 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 377
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 378 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 557
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 558 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVT 737
YGSGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEAT 193
Query: 738 PVFDNMVAQG-LVQPVFSFYLNRE 806
MV +G L PVFS YL+ +
Sbjct: 194 TAMQGMVQEGALTSPVFSVYLSNQ 217
Score = 50.0 bits (114), Expect = 2e-05
Identities = 22/62 (35%), Positives = 36/62 (58%), Gaps = 2/62 (3%)
Frame = +1
Query: 850 DPAHYRGDLVRVPLLRDTYWEFHMDS--VNVNASRFCAQGCSAIADTGTSLIAGPSXEVE 1023
D + Y G + P+ ++ YW+ ++ + AS +C++GC AI DTGTSL+ P +
Sbjct: 231 DSSLYTGQIYWAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMS 290
Query: 1024 AL 1029
AL
Sbjct: 291 AL 292
>M23077-1|AAA60063.1| 388|Homo sapiens pepsinogen C protein.
Length = 388
Score = 172 bits (418), Expect = 3e-42
Identities = 93/204 (45%), Positives = 127/204 (62%), Gaps = 10/204 (4%)
Frame = +3
Query: 225 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 377
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 378 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 557
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 558 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVT 737
YGSGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEAT 193
Query: 738 PVFDNMVAQG-LVQPVFSFYLNRE 806
MV +G L PVFS YL+ +
Sbjct: 194 TAMQGMVQEGALTSPVFSVYLSNQ 217
Score = 50.0 bits (114), Expect = 2e-05
Identities = 22/62 (35%), Positives = 36/62 (58%), Gaps = 2/62 (3%)
Frame = +1
Query: 850 DPAHYRGDLVRVPLLRDTYWEFHMDS--VNVNASRFCAQGCSAIADTGTSLIAGPSXEVE 1023
D + Y G + P+ ++ YW+ ++ + AS +C++GC AI DTGTSL+ P +
Sbjct: 231 DSSLYTGQIYWAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMS 290
Query: 1024 AL 1029
AL
Sbjct: 291 AL 292
>M18667-1|AAA60062.1| 385|Homo sapiens pepsinogen protein.
Length = 385
Score = 172 bits (418), Expect = 3e-42
Identities = 93/204 (45%), Positives = 127/204 (62%), Gaps = 10/204 (4%)
Frame = +3
Query: 225 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 377
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 14 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 72
Query: 378 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 557
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 73 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 130
Query: 558 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVT 737
YGSGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 131 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEAT 190
Query: 738 PVFDNMVAQG-LVQPVFSFYLNRE 806
MV +G L PVFS YL+ +
Sbjct: 191 TAMQGMVQEGALTSPVFSVYLSNQ 214
Score = 50.0 bits (114), Expect = 2e-05
Identities = 22/62 (35%), Positives = 36/62 (58%), Gaps = 2/62 (3%)
Frame = +1
Query: 850 DPAHYRGDLVRVPLLRDTYWEFHMDS--VNVNASRFCAQGCSAIADTGTSLIAGPSXEVE 1023
D + Y G + P+ ++ YW+ ++ + AS +C++GC AI DTGTSL+ P +
Sbjct: 228 DSSLYTGQIYWAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMS 287
Query: 1024 AL 1029
AL
Sbjct: 288 AL 289
>J04443-1|AAA60074.1| 388|Homo sapiens pepsinogen protein.
Length = 388
Score = 172 bits (418), Expect = 3e-42
Identities = 93/204 (45%), Positives = 127/204 (62%), Gaps = 10/204 (4%)
Frame = +3
Query: 225 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 377
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 378 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 557
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 558 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVT 737
YGSGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEAT 193
Query: 738 PVFDNMVAQG-LVQPVFSFYLNRE 806
MV +G L PVFS YL+ +
Sbjct: 194 TAMQGMVQEGALTSPVFSVYLSNQ 217
Score = 50.0 bits (114), Expect = 2e-05
Identities = 22/62 (35%), Positives = 36/62 (58%), Gaps = 2/62 (3%)
Frame = +1
Query: 850 DPAHYRGDLVRVPLLRDTYWEFHMDS--VNVNASRFCAQGCSAIADTGTSLIAGPSXEVE 1023
D + Y G + P+ ++ YW+ ++ + AS +C++GC AI DTGTSL+ P +
Sbjct: 231 DSSLYTGQIYWAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMS 290
Query: 1024 AL 1029
AL
Sbjct: 291 AL 292
>BC073740-1|AAH73740.1| 388|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 388
Score = 172 bits (418), Expect = 3e-42
Identities = 93/204 (45%), Positives = 127/204 (62%), Gaps = 10/204 (4%)
Frame = +3
Query: 225 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 377
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 378 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 557
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 558 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVT 737
YGSGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEAT 193
Query: 738 PVFDNMVAQG-LVQPVFSFYLNRE 806
MV +G L PVFS YL+ +
Sbjct: 194 TAMQGMVQEGALTSPVFSVYLSNQ 217
Score = 50.0 bits (114), Expect = 2e-05
Identities = 22/62 (35%), Positives = 36/62 (58%), Gaps = 2/62 (3%)
Frame = +1
Query: 850 DPAHYRGDLVRVPLLRDTYWEFHMDS--VNVNASRFCAQGCSAIADTGTSLIAGPSXEVE 1023
D + Y G + P+ ++ YW+ ++ + AS +C++GC AI DTGTSL+ P +
Sbjct: 231 DSSLYTGQIYWAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMS 290
Query: 1024 AL 1029
AL
Sbjct: 291 AL 292
>AL365205-1|CAI13181.1| 388|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 388
Score = 172 bits (418), Expect = 3e-42
Identities = 93/204 (45%), Positives = 127/204 (62%), Gaps = 10/204 (4%)
Frame = +3
Query: 225 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 377
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 378 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 557
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 558 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVT 737
YGSGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEAT 193
Query: 738 PVFDNMVAQG-LVQPVFSFYLNRE 806
MV +G L PVFS YL+ +
Sbjct: 194 TAMQGMVQEGALTSPVFSVYLSNQ 217
Score = 50.0 bits (114), Expect = 2e-05
Identities = 22/62 (35%), Positives = 36/62 (58%), Gaps = 2/62 (3%)
Frame = +1
Query: 850 DPAHYRGDLVRVPLLRDTYWEFHMDS--VNVNASRFCAQGCSAIADTGTSLIAGPSXEVE 1023
D + Y G + P+ ++ YW+ ++ + AS +C++GC AI DTGTSL+ P +
Sbjct: 231 DSSLYTGQIYWAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMS 290
Query: 1024 AL 1029
AL
Sbjct: 291 AL 292
>BC029055-1|AAH29055.1| 388|Homo sapiens pepsinogen 5, group I
(pepsinogen A) protein.
Length = 388
Score = 171 bits (415), Expect = 6e-42
Identities = 96/221 (43%), Positives = 129/221 (58%), Gaps = 13/221 (5%)
Frame = +3
Query: 189 LFFLALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRL-------KYDVTGPSP--- 338
L L L+A S +Y+VPL R K+ R E G + L+ KY +P
Sbjct: 4 LLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPTLV 63
Query: 339 --EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSR 512
+PL NYLD +Y+G I IGTP Q F VVFDTGSSNLWVPS C +++AC HN+++
Sbjct: 64 DEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYC--SSLACTNHNRFNPE 121
Query: 513 KSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDG 692
S TY + +I YG+GS++G L D V VGG+ Q F + +EPG A FDG
Sbjct: 122 DSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDG 181
Query: 693 ILGMAFSTIAVDHVTPVFDNMVAQGLV-QPVFSFYLNREPR 812
ILG+A+ +I+ TPVFDN+ QGLV Q +FS YL+ + +
Sbjct: 182 ILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDK 222
Score = 59.7 bits (138), Expect = 2e-08
Identities = 25/58 (43%), Positives = 37/58 (63%), Gaps = 1/58 (1%)
Frame = +1
Query: 850 DPAHYRGDLVRVPLLRDTYWEFHMDSVNVNASRF-CAQGCSAIADTGTSLIAGPSXEV 1020
D ++Y G L VP+ + YW+ +DS+ +N CA+GC AI DTGTSL+ GP+ +
Sbjct: 233 DSSYYTGSLNWVPVTVEGYWQITVDSITMNGETIACAEGCQAIVDTGTSLLTGPTSPI 290
>J00287-1|AAA98529.1| 388|Homo sapiens PEP protein.
Length = 388
Score = 170 bits (414), Expect = 8e-42
Identities = 96/219 (43%), Positives = 128/219 (58%), Gaps = 13/219 (5%)
Frame = +3
Query: 189 LFFLALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRL-------KYDVTGPSP--- 338
L L L+A S +Y+VPL R K+ R E G + L+ KY +P
Sbjct: 4 LLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPTLV 63
Query: 339 --EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSR 512
+PL NYLD +Y+G I IGTP Q F VVFDTGSSNLWVPS C +++AC HN+++
Sbjct: 64 DEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYC--SSLACTNHNRFNPE 121
Query: 513 KSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDG 692
S TY + +I YG+GS++G L D V VGG+ Q F + +EPG A FDG
Sbjct: 122 DSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDG 181
Query: 693 ILGMAFSTIAVDHVTPVFDNMVAQGLV-QPVFSFYLNRE 806
ILG+A+ +I+ TPVFDN+ QGLV Q +FS YL+ +
Sbjct: 182 ILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSAD 220
Score = 59.7 bits (138), Expect = 2e-08
Identities = 25/58 (43%), Positives = 37/58 (63%), Gaps = 1/58 (1%)
Frame = +1
Query: 850 DPAHYRGDLVRVPLLRDTYWEFHMDSVNVNASRF-CAQGCSAIADTGTSLIAGPSXEV 1020
D ++Y G L VP+ + YW+ +DS+ +N CA+GC AI DTGTSL+ GP+ +
Sbjct: 233 DSSYYTGSLNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPI 290
>M26032-1|AAA60061.1| 388|Homo sapiens pepsinogen A protein.
Length = 388
Score = 169 bits (410), Expect = 2e-41
Identities = 95/219 (43%), Positives = 128/219 (58%), Gaps = 13/219 (5%)
Frame = +3
Query: 189 LFFLALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRL-------KYDVTGPSP--- 338
L L L+A S +Y+VPL R K+ R E G + L+ KY +P
Sbjct: 4 LLLLGLVALSECIMYKVPLIRKKSFRRTLSERGLLKDFLKKHNLNPARKYFPQWKAPTLV 63
Query: 339 --EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSR 512
+PL NYLD +Y+G I IGTP Q F V+FDTGSSNLWVPS C +++AC HN+++
Sbjct: 64 DEQPLENYLDMEYFGTIGIGTPAQDFTVLFDTGSSNLWVPSVYC--SSLACTNHNRFNPE 121
Query: 513 KSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDG 692
S TY + +I YG+GS++G L D V VGG+ Q F + +EPG A FDG
Sbjct: 122 DSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDG 181
Query: 693 ILGMAFSTIAVDHVTPVFDNMVAQGLV-QPVFSFYLNRE 806
ILG+A+ +I+ TPVFDN+ QGLV Q +FS YL+ +
Sbjct: 182 ILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSAD 220
Score = 59.7 bits (138), Expect = 2e-08
Identities = 25/58 (43%), Positives = 37/58 (63%), Gaps = 1/58 (1%)
Frame = +1
Query: 850 DPAHYRGDLVRVPLLRDTYWEFHMDSVNVNASRF-CAQGCSAIADTGTSLIAGPSXEV 1020
D ++Y G L VP+ + YW+ +DS+ +N CA+GC AI DTGTSL+ GP+ +
Sbjct: 233 DSSYYTGSLNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPI 290
>X00063-1|CAA24937.1| 300|Homo sapiens protein ( Human kidney mRNA
fragment for renin (aa 105-401). ).
Length = 300
Score = 131 bits (317), Expect = 5e-30
Identities = 60/125 (48%), Positives = 84/125 (67%), Gaps = 1/125 (0%)
Frame = +3
Query: 435 SNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGG 614
SN+WVPS KC AC+ H +D+ S +Y NGT+ ++Y +G++SGFLS D +TVGG
Sbjct: 1 SNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGG 60
Query: 615 LKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPVFDNMVAQG-LVQPVFSF 791
+ V Q F E P L F+ A+FDG++GM F A+ VTP+FDN+++QG L + VFSF
Sbjct: 61 ITV-TQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSF 119
Query: 792 YLNRE 806
Y NR+
Sbjct: 120 YYNRD 124
Score = 54.4 bits (125), Expect = 9e-07
Identities = 24/62 (38%), Positives = 35/62 (56%), Gaps = 1/62 (1%)
Frame = +1
Query: 847 SDPAHYRGDLVRVPLLRDTYWEFHMDSVNVNASR-FCAQGCSAIADTGTSLIAGPSXEVE 1023
SDP HY G+ + L++ W+ M V+V +S C GC A+ DTG S I+G + +E
Sbjct: 140 SDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIE 199
Query: 1024 AL 1029
L
Sbjct: 200 KL 201
>BC014453-1|AAH14453.1| 518|Homo sapiens beta-site APP-cleaving
enzyme 2 protein.
Length = 518
Score = 72.1 bits (169), Expect = 4e-12
Identities = 47/147 (31%), Positives = 74/147 (50%), Gaps = 4/147 (2%)
Frame = +3
Query: 369 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 548
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 549 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 722
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 723 --VDHVTPVFDNMVAQGLVQPVFSFYL 797
+ FD++V Q + VFS +
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFSMQM 232
>AY358927-1|AAQ89286.1| 518|Homo sapiens BACE2 protein.
Length = 518
Score = 72.1 bits (169), Expect = 4e-12
Identities = 47/147 (31%), Positives = 74/147 (50%), Gaps = 4/147 (2%)
Frame = +3
Query: 369 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 548
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 549 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 722
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 723 --VDHVTPVFDNMVAQGLVQPVFSFYL 797
+ FD++V Q + VFS +
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFSMQM 232
>AF212252-1|AAG41783.1| 439|Homo sapiens CDA13 protein.
Length = 439
Score = 72.1 bits (169), Expect = 4e-12
Identities = 47/147 (31%), Positives = 74/147 (50%), Gaps = 4/147 (2%)
Frame = +3
Query: 369 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 548
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 13 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 66
Query: 549 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 722
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 67 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 126
Query: 723 --VDHVTPVFDNMVAQGLVQPVFSFYL 797
+ FD++V Q + VFS +
Sbjct: 127 KPSSSLETFFDSLVTQANIPNVFSMQM 153
>AF204944-1|AAF26368.1| 518|Homo sapiens transmembrane aspartic
proteinase Asp 1 protein.
Length = 518
Score = 72.1 bits (169), Expect = 4e-12
Identities = 47/147 (31%), Positives = 74/147 (50%), Gaps = 4/147 (2%)
Frame = +3
Query: 369 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 548
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 549 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 722
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 723 --VDHVTPVFDNMVAQGLVQPVFSFYL 797
+ FD++V Q + VFS +
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFSMQM 232
>AF200342-1|AAF17078.1| 518|Homo sapiens aspartyl protease 1
protein.
Length = 518
Score = 72.1 bits (169), Expect = 4e-12
Identities = 47/147 (31%), Positives = 74/147 (50%), Gaps = 4/147 (2%)
Frame = +3
Query: 369 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 548
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 549 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 722
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 723 --VDHVTPVFDNMVAQGLVQPVFSFYL 797
+ FD++V Q + VFS +
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFSMQM 232
>AF200192-1|AAF13714.1| 518|Homo sapiens memapsin 1 protein.
Length = 518
Score = 72.1 bits (169), Expect = 4e-12
Identities = 47/147 (31%), Positives = 74/147 (50%), Gaps = 4/147 (2%)
Frame = +3
Query: 369 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 548
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 549 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 722
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 723 --VDHVTPVFDNMVAQGLVQPVFSFYL 797
+ FD++V Q + VFS +
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFSMQM 232
>AF188277-1|AAF35836.1| 396|Homo sapiens aspartyl protease protein.
Length = 396
Score = 72.1 bits (169), Expect = 4e-12
Identities = 47/147 (31%), Positives = 74/147 (50%), Gaps = 4/147 (2%)
Frame = +3
Query: 369 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 548
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 549 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 722
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 723 --VDHVTPVFDNMVAQGLVQPVFSFYL 797
+ FD++V Q + VFS +
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFSMQM 232
>AF188276-1|AAF35835.1| 468|Homo sapiens aspartyl protease protein.
Length = 468
Score = 72.1 bits (169), Expect = 4e-12
Identities = 47/147 (31%), Positives = 74/147 (50%), Gaps = 4/147 (2%)
Frame = +3
Query: 369 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 548
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 549 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 722
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 723 --VDHVTPVFDNMVAQGLVQPVFSFYL 797
+ FD++V Q + VFS +
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFSMQM 232
>AF178532-1|AAF29494.1| 518|Homo sapiens aspartyl protease protein.
Length = 518
Score = 72.1 bits (169), Expect = 4e-12
Identities = 47/147 (31%), Positives = 74/147 (50%), Gaps = 4/147 (2%)
Frame = +3
Query: 369 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 548
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 549 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 722
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 723 --VDHVTPVFDNMVAQGLVQPVFSFYL 797
+ FD++V Q + VFS +
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFSMQM 232
>AF117892-1|AAD45240.1| 518|Homo sapiens aspartic-like protease
protein.
Length = 518
Score = 72.1 bits (169), Expect = 4e-12
Identities = 47/147 (31%), Positives = 74/147 (50%), Gaps = 4/147 (2%)
Frame = +3
Query: 369 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 548
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 549 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 722
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 723 --VDHVTPVFDNMVAQGLVQPVFSFYL 797
+ FD++V Q + VFS +
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFSMQM 232
>AF050171-1|AAD45963.1| 518|Homo sapiens aspartyl protease protein.
Length = 518
Score = 72.1 bits (169), Expect = 4e-12
Identities = 47/147 (31%), Positives = 74/147 (50%), Gaps = 4/147 (2%)
Frame = +3
Query: 369 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 548
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 549 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 722
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 723 --VDHVTPVFDNMVAQGLVQPVFSFYL 797
+ FD++V Q + VFS +
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFSMQM 232
>AK075539-1|BAC11682.1| 423|Homo sapiens protein ( Homo sapiens
cDNA PSEC0239 fis, clone OVARC1000363, highly similar to
Homo sapiens aspartyl protease mRNA. ).
Length = 423
Score = 70.9 bits (166), Expect = 9e-12
Identities = 45/141 (31%), Positives = 72/141 (51%), Gaps = 4/141 (2%)
Frame = +3
Query: 387 IGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGS 566
IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G ++Y
Sbjct: 3 IGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDVTVKYTQ 56
Query: 567 GSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA--VDHV 734
GS +GF+ D VT+ G + E G F+ +++GILG+A++T+A +
Sbjct: 57 GSWTGFVGEDLVTIPKGFNTSFLVNIATIFESGNFFLPGIQWNGILGLAYATLAKPSSSL 116
Query: 735 TPVFDNMVAQGLVQPVFSFYL 797
FD++V Q + VFS +
Sbjct: 117 ETFFDSLVTQANIPNVFSMQM 137
>DQ007053-1|AAY16982.1| 501|Homo sapiens beta-site APP-cleaving
enzyme 1 protein.
Length = 501
Score = 67.7 bits (158), Expect = 9e-11
Identities = 48/147 (32%), Positives = 75/147 (51%), Gaps = 4/147 (2%)
Frame = +3
Query: 369 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 548
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 549 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 722
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 723 --VDHVTPVFDNMVAQGLVQPVFSFYL 797
D + P FD++V Q V +FS L
Sbjct: 189 RPDDSLEPFFDSLVKQTHVPNLFSLQL 215
>BC065492-1|AAH65492.1| 501|Homo sapiens beta-site APP-cleaving
enzyme 1 protein.
Length = 501
Score = 67.7 bits (158), Expect = 9e-11
Identities = 48/147 (32%), Positives = 75/147 (51%), Gaps = 4/147 (2%)
Frame = +3
Query: 369 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 548
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 549 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 722
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 723 --VDHVTPVFDNMVAQGLVQPVFSFYL 797
D + P FD++V Q V +FS L
Sbjct: 189 RPDDSLEPFFDSLVKQTHVPNLFSLQL 215
>AF204943-1|AAF26367.1| 501|Homo sapiens transmembrane aspartic
proteinase Asp 2 protein.
Length = 501
Score = 67.7 bits (158), Expect = 9e-11
Identities = 48/147 (32%), Positives = 75/147 (51%), Gaps = 4/147 (2%)
Frame = +3
Query: 369 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 548
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 549 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 722
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 723 --VDHVTPVFDNMVAQGLVQPVFSFYL 797
D + P FD++V Q V +FS L
Sbjct: 189 RPDDSLEPFFDSLVKQTHVPNLFSLQL 215
>AF201468-1|AAF18982.1| 501|Homo sapiens APP beta-secretase
protein.
Length = 501
Score = 67.7 bits (158), Expect = 9e-11
Identities = 48/147 (32%), Positives = 75/147 (51%), Gaps = 4/147 (2%)
Frame = +3
Query: 369 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 548
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 549 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 722
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 723 --VDHVTPVFDNMVAQGLVQPVFSFYL 797
D + P FD++V Q V +FS L
Sbjct: 189 RPDDSLEPFFDSLVKQTHVPNLFSLQL 215
>AF200343-1|AAF17079.1| 501|Homo sapiens aspartyl protease 2
protein.
Length = 501
Score = 67.7 bits (158), Expect = 9e-11
Identities = 48/147 (32%), Positives = 75/147 (51%), Gaps = 4/147 (2%)
Frame = +3
Query: 369 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 548
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 549 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 722
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 723 --VDHVTPVFDNMVAQGLVQPVFSFYL 797
D + P FD++V Q V +FS L
Sbjct: 189 RPDDSLEPFFDSLVKQTHVPNLFSLQL 215
>AF200193-1|AAF13715.1| 488|Homo sapiens memapsin 2 protein.
Length = 488
Score = 67.7 bits (158), Expect = 9e-11
Identities = 48/147 (32%), Positives = 75/147 (51%), Gaps = 4/147 (2%)
Frame = +3
Query: 369 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 548
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 62 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 115
Query: 549 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 722
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 116 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 175
Query: 723 --VDHVTPVFDNMVAQGLVQPVFSFYL 797
D + P FD++V Q V +FS L
Sbjct: 176 RPDDSLEPFFDSLVKQTHVPNLFSLQL 202
>AF190725-1|AAF04142.1| 501|Homo sapiens beta-site APP cleaving
enzyme protein.
Length = 501
Score = 67.7 bits (158), Expect = 9e-11
Identities = 48/147 (32%), Positives = 75/147 (51%), Gaps = 4/147 (2%)
Frame = +3
Query: 369 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 548
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 549 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 722
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 723 --VDHVTPVFDNMVAQGLVQPVFSFYL 797
D + P FD++V Q V +FS L
Sbjct: 189 RPDDSLEPFFDSLVKQTHVPNLFSLQL 215
>AB032975-1|BAA86463.2| 532|Homo sapiens KIAA1149 protein protein.
Length = 532
Score = 67.7 bits (158), Expect = 9e-11
Identities = 48/147 (32%), Positives = 75/147 (51%), Gaps = 4/147 (2%)
Frame = +3
Query: 369 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 548
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 106 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 159
Query: 549 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 722
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 160 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 219
Query: 723 --VDHVTPVFDNMVAQGLVQPVFSFYL 797
D + P FD++V Q V +FS L
Sbjct: 220 RPDDSLEPFFDSLVKQTHVPNLFSLQL 246
>BC036084-1|AAH36084.1| 501|Homo sapiens beta-site APP-cleaving
enzyme 1 protein.
Length = 501
Score = 65.3 bits (152), Expect = 5e-10
Identities = 47/147 (31%), Positives = 74/147 (50%), Gaps = 4/147 (2%)
Frame = +3
Query: 369 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 548
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLFSTYRDLRKGV 128
Query: 549 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 722
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 723 --VDHVTPVFDNMVAQGLVQPVFSFYL 797
D + P FD++V Q V +FS L
Sbjct: 189 RPDDSLEPFFDSLVKQTHVPNLFSLQL 215
>AL365205-2|CAI95135.1| 140|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 140
Score = 60.5 bits (140), Expect = 1e-08
Identities = 29/68 (42%), Positives = 42/68 (61%), Gaps = 1/68 (1%)
Frame = +3
Query: 606 VGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPVFDNMVAQG-LVQPV 782
V ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T MV +G L PV
Sbjct: 71 VQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPV 130
Query: 783 FSFYLNRE 806
FS YL+ +
Sbjct: 131 FSVYLSNQ 138
>BC042578-1|AAH42578.1| 104|Homo sapiens PGC protein protein.
Length = 104
Score = 60.1 bits (139), Expect = 2e-08
Identities = 38/82 (46%), Positives = 49/82 (59%), Gaps = 9/82 (10%)
Frame = +3
Query: 225 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 377
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 378 VISIGTPPQSFKVVFDTGSSNL 443
ISIGTPPQ+F V+FDTGSS L
Sbjct: 76 EISIGTPPQNFLVLFDTGSSPL 97
>AF338816-1|AAK38374.1| 476|Homo sapiens beta-site APP cleaving
enzyme type B protein.
Length = 476
Score = 56.4 bits (130), Expect = 2e-07
Identities = 38/120 (31%), Positives = 61/120 (50%), Gaps = 2/120 (1%)
Frame = +3
Query: 369 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 548
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 549 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 722
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
>AB050436-1|BAB40931.1| 476|Homo sapiens beta-site APP cleaving
enzyme I-476 protein.
Length = 476
Score = 56.4 bits (130), Expect = 2e-07
Identities = 38/120 (31%), Positives = 61/120 (50%), Gaps = 2/120 (1%)
Frame = +3
Query: 369 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 548
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 549 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 722
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
>AL163285-1|CAB90554.1| 415|Homo sapiens beta-site APP-cleaving
enzyme 2, EC 3.4.23. protein.
Length = 415
Score = 55.6 bits (128), Expect = 4e-07
Identities = 39/133 (29%), Positives = 65/133 (48%), Gaps = 4/133 (3%)
Frame = +3
Query: 411 KVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLS 590
+++ DTGSSN V Y + +D+ +S TY + G ++Y GS +GF+
Sbjct: 3 QILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVG 56
Query: 591 TDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA--VDHVTPVFDNMV 758
D VT+ G + E F+ K++GILG+A++T+A + FD++V
Sbjct: 57 EDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLV 116
Query: 759 AQGLVQPVFSFYL 797
Q + VFS +
Sbjct: 117 TQANIPNVFSMQM 129
>AB050438-1|BAB40933.1| 432|Homo sapiens beta-site APP cleaving
enzyme I-432 protein.
Length = 432
Score = 42.3 bits (95), Expect = 0.004
Identities = 27/94 (28%), Positives = 42/94 (44%)
Frame = +3
Query: 369 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 548
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 549 AIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAV 650
+ Y G G L TD + G + + +V
Sbjct: 129 YVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASV 162
>AF338817-1|AAK38375.1| 457|Homo sapiens beta-site APP cleaving
enzyme type C protein.
Length = 457
Score = 41.9 bits (94), Expect = 0.005
Identities = 25/76 (32%), Positives = 36/76 (47%)
Frame = +3
Query: 369 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 548
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 549 AIQYGSGSLSGFLSTD 596
+ Y G G L TD
Sbjct: 129 YVPYTQGKWEGELGTD 144
>AB050437-1|BAB40932.1| 457|Homo sapiens beta-site APP cleaving
enzyme I-457 protein.
Length = 457
Score = 41.9 bits (94), Expect = 0.005
Identities = 25/76 (32%), Positives = 36/76 (47%)
Frame = +3
Query: 369 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 548
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 549 AIQYGSGSLSGFLSTD 596
+ Y G G L TD
Sbjct: 129 YVPYTQGKWEGELGTD 144
>AB177847-1|BAD66825.1| 396|Homo sapiens KIAA1149 splice variant 1
protein.
Length = 396
Score = 41.5 bits (93), Expect = 0.006
Identities = 29/86 (33%), Positives = 46/86 (53%), Gaps = 4/86 (4%)
Frame = +3
Query: 552 IQYGSGSLSGFLSTDDVTVG-GLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA- 722
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 25 VPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIAR 84
Query: 723 -VDHVTPVFDNMVAQGLVQPVFSFYL 797
D + P FD++V Q V +FS L
Sbjct: 85 PDDSLEPFFDSLVKQTHVPNLFSLQL 110
>AL365205-3|CAM16152.1| 86|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 86
Score = 38.7 bits (86), Expect = 0.045
Identities = 28/70 (40%), Positives = 37/70 (52%), Gaps = 9/70 (12%)
Frame = +3
Query: 216 SVMALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQ 368
+V+ RVPL + K+ R E G E LR KYD + EP++ Y+DA
Sbjct: 18 AVICKQRVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAA 76
Query: 369 YYGVISIGTP 398
Y+G ISIGTP
Sbjct: 77 YFGEISIGTP 86
>AB089958-1|BAC81826.1| 127|Homo sapiens beta-site APP cleaving
enzyme isoform I-127 protein.
Length = 127
Score = 36.7 bits (81), Expect = 0.18
Identities = 19/53 (35%), Positives = 29/53 (54%)
Frame = +3
Query: 369 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTY 527
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTY 121
>M11437-2|AAB59550.1| 644|Homo sapiens kininogen protein.
Length = 644
Score = 33.1 bits (72), Expect = 2.2
Identities = 22/65 (33%), Positives = 27/65 (41%)
Frame = -2
Query: 788 REDGLHESLSHHVVEHRGHMVHCDSAEGHPEDPVELGGHEGKPGLRHGLGERLAPHLEPA 609
R D HE H + H GH D GH GHE + GL HG +L LE
Sbjct: 428 RHDWGHEKQRKHNLGH-GHKHERDQGHGHQRGHGLGHGHEQQHGLGHGHKFKLDDDLEHQ 486
Query: 608 HGDII 594
G ++
Sbjct: 487 GGHVL 491
>AF141344-1|AAG49447.1| 119|Homo sapiens LYST-interacting protein
LIP8 protein.
Length = 119
Score = 32.3 bits (70), Expect = 3.9
Identities = 13/33 (39%), Positives = 16/33 (48%)
Frame = -1
Query: 591 WRGSRRGCRSRTVSRTGCHSRRTSWTCGCRTCC 493
W GS+R C + V + S SW CR CC
Sbjct: 8 WPGSKRECANCRVGTSSWRSSGWSWWKDCRPCC 40
>AK055141-1|BAB70862.1| 260|Homo sapiens protein ( Homo sapiens
cDNA FLJ30579 fis, clone BRAWH2006989, weakly similar to
DNA-DIRECTED RNA POLYMERASE II LARGEST SUBUNIT (EC
2.7.7.6). ).
Length = 260
Score = 31.9 bits (69), Expect = 5.2
Identities = 17/35 (48%), Positives = 18/35 (51%)
Frame = -1
Query: 600 HHQWRGSRRGCRSRTVSRTGCHSRRTSWTCGCRTC 496
H+ W GS R C S T S G HS SWT R C
Sbjct: 26 HNSWTGSNRACSSWTGSTRG-HS---SWTGSSRAC 56
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 162,261,901
Number of Sequences: 237096
Number of extensions: 3388450
Number of successful extensions: 9130
Number of sequences better than 10.0: 74
Number of HSP's better than 10.0 without gapping: 8021
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 8990
length of database: 76,859,062
effective HSP length: 92
effective length of database: 55,046,230
effective search space used: 18495533280
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
- SilkBase 1999-2023 -