Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fdpeP13_F_F11
(957 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q16RI0 Cluster: Glutamate decarboxylase; n=4; Endoptery... 58 3e-07
UniRef50_Q49AK1 Cluster: GAD1 protein; n=10; Euteleostomi|Rep: G... 57 8e-07
UniRef50_Q99259 Cluster: Glutamate decarboxylase 1; n=61; Bilate... 57 8e-07
UniRef50_Q05329 Cluster: Glutamate decarboxylase 2; n=50; Coelom... 52 3e-05
UniRef50_Q24062 Cluster: Glutamate decarboxylase; n=8; Coelomata... 47 8e-04
UniRef50_Q17JW3 Cluster: Glutamate decarboxylase; n=1; Aedes aeg... 47 8e-04
UniRef50_O93275 Cluster: Glutamate decarboxylase; n=15; Chordata... 46 0.001
UniRef50_UPI0000E46668 Cluster: PREDICTED: similar to CSAD prote... 42 0.023
UniRef50_Q4RNU0 Cluster: Chromosome 2 SCAF15010, whole genome sh... 37 0.87
UniRef50_UPI0000EB6F53 Cluster: Glutamate decarboxylase 1 (EC 4.... 36 1.2
UniRef50_UPI0001555518 Cluster: PREDICTED: similar to cysteine s... 34 4.7
UniRef50_UPI000150A11C Cluster: Pyridoxal-dependent decarboxylas... 34 6.2
UniRef50_A0L6T9 Cluster: Pyridoxal-dependent decarboxylase; n=1;... 33 8.2
>UniRef50_Q16RI0 Cluster: Glutamate decarboxylase; n=4;
Endopterygota|Rep: Glutamate decarboxylase - Aedes
aegypti (Yellowfever mosquito)
Length = 425
Score = 58.0 bits (134), Expect = 3e-07
Identities = 41/145 (28%), Positives = 54/145 (37%)
Frame = +1
Query: 442 TXAFNTXQYTFEVXPIXXLIXLXVXNHILXXSGIPXGDXIXSPVGXVSXXXXXXXXXXXX 621
T A NT QYTFEV P+ LI + L G GD I SP G +S
Sbjct: 95 TDALNTSQYTFEVGPVFTLIEDALIKKCLALFGFQDGDGILSPGGSISNMYAMVAARFRA 154
Query: 622 FPXFDTKXITXLPXIXIXSXEDXHYSXKKXXHXLRFRTKSLPXIXXNEXWQXXVXELXXA 801
P + P + + E+ HYS KK H L +L + + + EL +
Sbjct: 155 LPDVKRTGLANQPTLVAFTSEEAHYSIKKAVHWLGIGIDNLVLVKTDCRGRMIPDELEKS 214
Query: 802 IXXXXXXAYFXLXXXAXDXTXVLGA 876
I + T VLGA
Sbjct: 215 IEAVIESGRKPFFLNSTAGTTVLGA 239
>UniRef50_Q49AK1 Cluster: GAD1 protein; n=10; Euteleostomi|Rep: GAD1
protein - Homo sapiens (Human)
Length = 425
Score = 56.8 bits (131), Expect = 8e-07
Identities = 42/148 (28%), Positives = 57/148 (38%), Gaps = 3/148 (2%)
Frame = +1
Query: 442 TXAFNTXQYTFEVXPIXXL---IXLXVXNHILXXSGIPXGDXIXSPVGXVSXXXXXXXXX 612
T NT +T+E+ P+ L I L I+ S GD I SP G +S
Sbjct: 206 TSTANTNMFTYEIAPVFVLMEQITLKKMREIVGWSS-KDGDGIFSPGGAISNMYSIMAAR 264
Query: 613 XXXFPXFDTKXITXLPXIXIXSXEDXHYSXKKXXHXLRFRTKSLPXIXXNEXWQXXVXEL 792
FP TK + +P + + + E HYS KK L F T ++ I NE + +
Sbjct: 265 YKYFPEVKTKGMAAVPKLVLFTSEQSHYSIKKAGAALGFGTDNVILIKCNERGKIIPADF 324
Query: 793 XXAIXXXXXXAYFXLXXXAXDXTXVLGA 876
I Y A T V GA
Sbjct: 325 EAKILEAKQKGYVPFYVNATAGTTVYGA 352
>UniRef50_Q99259 Cluster: Glutamate decarboxylase 1; n=61;
Bilateria|Rep: Glutamate decarboxylase 1 - Homo sapiens
(Human)
Length = 594
Score = 56.8 bits (131), Expect = 8e-07
Identities = 42/148 (28%), Positives = 57/148 (38%), Gaps = 3/148 (2%)
Frame = +1
Query: 442 TXAFNTXQYTFEVXPIXXL---IXLXVXNHILXXSGIPXGDXIXSPVGXVSXXXXXXXXX 612
T NT +T+E+ P+ L I L I+ S GD I SP G +S
Sbjct: 206 TSTANTNMFTYEIAPVFVLMEQITLKKMREIVGWSS-KDGDGIFSPGGAISNMYSIMAAR 264
Query: 613 XXXFPXFDTKXITXLPXIXIXSXEDXHYSXKKXXHXLRFRTKSLPXIXXNEXWQXXVXEL 792
FP TK + +P + + + E HYS KK L F T ++ I NE + +
Sbjct: 265 YKYFPEVKTKGMAAVPKLVLFTSEQSHYSIKKAGAALGFGTDNVILIKCNERGKIIPADF 324
Query: 793 XXAIXXXXXXAYFXLXXXAXDXTXVLGA 876
I Y A T V GA
Sbjct: 325 EAKILEAKQKGYVPFYVNATAGTTVYGA 352
>UniRef50_Q05329 Cluster: Glutamate decarboxylase 2; n=50;
Coelomata|Rep: Glutamate decarboxylase 2 - Homo sapiens
(Human)
Length = 585
Score = 51.6 bits (118), Expect = 3e-05
Identities = 38/147 (25%), Positives = 54/147 (36%), Gaps = 2/147 (1%)
Frame = +1
Query: 442 TXAFNTXQYTFEVXPIXXLIXLXVXNHILXXSGIPXG--DXIXSPVGXVSXXXXXXXXXX 615
T NT +T+E+ P+ L+ + G P G D I SP G +S
Sbjct: 197 TSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFSPGGAISNMYAMMIARF 256
Query: 616 XXFPXFDTKXITXLPXIXIXSXEDXHYSXKKXXHXLRFRTKSLPXIXXNEXWQXXVXELX 795
FP K + LP + + E H+S KK L T S+ I +E + +L
Sbjct: 257 KMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVILIKCDERGKMIPSDLE 316
Query: 796 XAIXXXXXXAYFXLXXXAXDXTXVLGA 876
I + A T V GA
Sbjct: 317 RRILEAKQKGFVPFLVSATAGTTVYGA 343
>UniRef50_Q24062 Cluster: Glutamate decarboxylase; n=8;
Coelomata|Rep: Glutamate decarboxylase - Drosophila
melanogaster (Fruit fly)
Length = 575
Score = 46.8 bits (106), Expect = 8e-04
Identities = 37/148 (25%), Positives = 55/148 (37%), Gaps = 3/148 (2%)
Frame = +1
Query: 442 TXAFNTXQYTFEVXPIXXLIXLXVXNHILXXSGIP---XGDXIXSPVGXVSXXXXXXXXX 612
T A N YT+EV P+ L+ V + G P GD I P G ++
Sbjct: 187 TDALNPSVYTYEVAPLFTLMEEQVLAEMRRIVGFPNGGQGDGIFCPGGSIANGYAISCAR 246
Query: 613 XXXFPXFDTKXITXLPXIXIXSXEDXHYSXKKXXHXLRFRTKSLPXIXXNEXWQXXVXEL 792
P + + I + ED HYS +K + F + + I NE + + +L
Sbjct: 247 YRHSPESKKNGLFNAKPLIIFTSEDAHYSVEKLAMFMGFGSDHVRKIATNEVGKMRLSDL 306
Query: 793 XXAIXXXXXXAYFXLXXXAXDXTXVLGA 876
+ + L A T VLGA
Sbjct: 307 EKQVKLCLENGWQPLMVSATAGTTVLGA 334
>UniRef50_Q17JW3 Cluster: Glutamate decarboxylase; n=1; Aedes
aegypti|Rep: Glutamate decarboxylase - Aedes aegypti
(Yellowfever mosquito)
Length = 540
Score = 46.8 bits (106), Expect = 8e-04
Identities = 33/161 (20%), Positives = 56/161 (34%)
Frame = +1
Query: 442 TXAFNTXQYTFEVXPIXXLIXLXVXNHILXXSGIPXGDXIXSPVGXVSXXXXXXXXXXXX 621
T A N Q+T+E P+ L+ + L G G+ + +P G ++
Sbjct: 149 TDALNACQFTYEAAPVFSLVESFTLKYFLKLCGFEAGEGVFTPGGSMANMYAPAMARHRL 208
Query: 622 FPXFDTKXITXLPXIXIXSXEDXHYSXKKXXHXLRFRTKSLPXIXXNEXWQXXVXELXXA 801
FP + + + + ED HYS K + L +++ + + + EL A
Sbjct: 209 FPENKKHGMYSCQKLKMFTSEDSHYSVTKSANWLGLGEENVLRVRTDATSRIDTTELEVA 268
Query: 802 IXXXXXXAYFXLXXXAXDXTXVLGAXXXXNXXXXXXXKHAV 924
I L T V GA N +H +
Sbjct: 269 IVRSIAEGDKPLIVSVTAGTTVFGAFDDLNRVADICQQHQI 309
>UniRef50_O93275 Cluster: Glutamate decarboxylase; n=15;
Chordata|Rep: Glutamate decarboxylase - Danio rerio
(Zebrafish) (Brachydanio rerio)
Length = 232
Score = 46.0 bits (104), Expect = 0.001
Identities = 38/155 (24%), Positives = 55/155 (35%), Gaps = 2/155 (1%)
Frame = +1
Query: 466 YTFEVXPIXXLIXLXVXNHILXXSGIPXG--DXIXSPVGXVSXXXXXXXXXXXXFPXFDT 639
+T+EV P+ L+ + G G D I SP G +S FP
Sbjct: 1 FTYEVAPVFVLLEYVTLKKMREIIGWQDGRGDGIFSPGGAISNMYAMLLARYKMFPEVKE 60
Query: 640 KXITXLPXIXIXSXEDXHYSXKKXXHXLRFRTKSLPXIXXNEXWQXXVXELXXAIXXXXX 819
K ++ +P + + E H+S KK L T+S+ I +E + +L I
Sbjct: 61 KGMSSVPRLVAFTSEHSHFSIKKGAAALGIGTESVICIKADERGKMIPSDLERRIIEAKQ 120
Query: 820 XAYFXLXXXAXDXTXVLGAXXXXNXXXXXXXKHAV 924
Y A T V GA KH V
Sbjct: 121 KGYVPFFVSATAGTTVYGAFDPLIAIADICKKHDV 155
>UniRef50_UPI0000E46668 Cluster: PREDICTED: similar to CSAD protein;
n=3; Strongylocentrotus purpuratus|Rep: PREDICTED:
similar to CSAD protein - Strongylocentrotus purpuratus
Length = 579
Score = 41.9 bits (94), Expect = 0.023
Identities = 36/161 (22%), Positives = 53/161 (32%)
Frame = +1
Query: 442 TXAFNTXQYTFEVXPIXXLIXLXVXNHILXXSGIPXGDXIXSPVGXVSXXXXXXXXXXXX 621
T + N QYT+EV P+ LI V + + G GD I P G +
Sbjct: 191 TESLNESQYTYEVAPVFTLIEQEVLSKLRELCGYKSGDGIFCPGGSLGNMYAINHARYMV 250
Query: 622 FPXFDTKXITXLPXIXIXSXEDXHYSXKKXXHXLRFRTKSLPXIXXNEXWQXXVXELXXA 801
+ + I + + HYS K L T ++ I ++ + L A
Sbjct: 251 NEDYKENGNFNSKPLQIFTSDQSHYSLLKGSAFLGIGTNNVIKIETDKNGRMIPEALDRA 310
Query: 802 IXXXXXXAYFXLXXXAXDXTXVLGAXXXXNXXXXXXXKHAV 924
I L A T V GA N K+ +
Sbjct: 311 ISAAKLNGAIPLMVVATSGTTVYGAYDPLNEIADICVKYGI 351
>UniRef50_Q4RNU0 Cluster: Chromosome 2 SCAF15010, whole genome
shotgun sequence; n=2; Tetraodon nigroviridis|Rep:
Chromosome 2 SCAF15010, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 520
Score = 36.7 bits (81), Expect = 0.87
Identities = 22/83 (26%), Positives = 33/83 (39%), Gaps = 2/83 (2%)
Frame = +1
Query: 442 TXAFNTXQYTFEVXPIXXLIXLXVXNHILXXSGIP--XGDXIXSPVGXVSXXXXXXXXXX 615
T NT +T+E+ P+ L+ + G P GD I SP G +S
Sbjct: 148 TSTANTNMFTYEIAPVFVLMEQLTLKKMREIVGWPGGEGDGIFSPGGAISNMYSVMIARY 207
Query: 616 XXFPXFDTKXITXLPXIXIXSXE 684
FP TK + P + + + E
Sbjct: 208 KFFPVVKTKGMAAAPRLVLFTSE 230
>UniRef50_UPI0000EB6F53 Cluster: Glutamate decarboxylase 1 (EC
4.1.1.15) (Glutamate decarboxylase 67 kDa isoform)
(GAD-67) (67 kDa glutamic acid decarboxylase).; n=1;
Danio rerio|Rep: Glutamate decarboxylase 1 (EC 4.1.1.15)
(Glutamate decarboxylase 67 kDa isoform) (GAD-67) (67
kDa glutamic acid decarboxylase). - Danio rerio
Length = 613
Score = 36.3 bits (80), Expect = 1.2
Identities = 21/83 (25%), Positives = 34/83 (40%), Gaps = 2/83 (2%)
Frame = +1
Query: 442 TXAFNTXQYTFEVXPIXXLIXLXVXNHILXXSGIP--XGDXIXSPVGXVSXXXXXXXXXX 615
T NT +T+E+ P+ L+ + G P GD + SP G +S
Sbjct: 199 TSTANTNMFTYEIAPVFVLMEQLTLKKMREIIGWPNGDGDALFSPGGAISNMYSVMVARY 258
Query: 616 XXFPXFDTKXITXLPXIXIXSXE 684
FP TK ++ P + + + E
Sbjct: 259 KYFPEVKTKGMSAAPRLVLFTSE 281
>UniRef50_UPI0001555518 Cluster: PREDICTED: similar to cysteine
sulfinate decarboxylase, partial; n=1; Ornithorhynchus
anatinus|Rep: PREDICTED: similar to cysteine sulfinate
decarboxylase, partial - Ornithorhynchus anatinus
Length = 246
Score = 34.3 bits (75), Expect = 4.7
Identities = 23/89 (25%), Positives = 37/89 (41%), Gaps = 1/89 (1%)
Frame = +1
Query: 424 GRFIKKTXAFNTXQYTFEVXPIXXLIXLXVXNHILXXSG-IPXGDXIXSPVGXVSXXXXX 600
GRFI +T N QYT+EV P+ L+ V + G G + P G +S
Sbjct: 93 GRFITET--LNIRQYTYEVAPVFVLMEEAVLQKLRALVGWTNPGGGVFCPGGSISNMYAL 150
Query: 601 XXXXXXXFPXFDTKXITXLPXIXIXSXED 687
FP + + LP + + + ++
Sbjct: 151 NLARYRRFPDCKERGMRALPALVLFTSQE 179
>UniRef50_UPI000150A11C Cluster: Pyridoxal-dependent decarboxylase
conserved domain containing protein; n=1; Tetrahymena
thermophila SB210|Rep: Pyridoxal-dependent decarboxylase
conserved domain containing protein - Tetrahymena
thermophila SB210
Length = 501
Score = 33.9 bits (74), Expect = 6.2
Identities = 28/112 (25%), Positives = 42/112 (37%), Gaps = 4/112 (3%)
Frame = +1
Query: 442 TXAFNTXQYTFEVXPIXXLIXLXVXN----HILXXSGIPXGDXIXSPVGXVSXXXXXXXX 609
T N YT+E+ P+ + + L S I D + P G S
Sbjct: 106 TSTINGSMYTYEMAPVFNFMENAIQQLFAERYLKWSTI---DGVFCPGGSQSNFYGILAA 162
Query: 610 XXXXFPXFDTKXITXLPXIXIXSXEDXHYSXKKXXHXLRFRTKSLPXIXXNE 765
+P F K + LP + + + E HYS +K L F S+ I +E
Sbjct: 163 RQHKYPEFKRKGLRALPDLKLFTSELAHYSIEKGAIMLGFGLDSVVKIACDE 214
>UniRef50_A0L6T9 Cluster: Pyridoxal-dependent decarboxylase; n=1;
Magnetococcus sp. MC-1|Rep: Pyridoxal-dependent
decarboxylase - Magnetococcus sp. (strain MC-1)
Length = 475
Score = 33.5 bits (73), Expect = 8.2
Identities = 32/145 (22%), Positives = 47/145 (32%)
Frame = +1
Query: 442 TXAFNTXQYTFEVXPIXXLIXLXVXNHILXXSGIPXGDXIXSPVGXVSXXXXXXXXXXXX 621
T NT YT+EV P+ L+ + + +G D I S G S
Sbjct: 97 TALTNTSMYTYEVAPLATLMERFLIEKMGKLAGFTNHDGIFSSGGSNSNLIAMLCARQQR 156
Query: 622 FPXFDTKXITXLPXIXIXSXEDXHYSXKKXXHXLRFRTKSLPXIXXNEXWQXXVXELXXA 801
FP + P + + HYS ++ L +L + + + L A
Sbjct: 157 FPHIKQLGNSNAPPLVCLVSDQAHYSFQRGAMVLGMGLDNLVKVASDPQGRMQPAALEAA 216
Query: 802 IXXXXXXAYFXLXXXAXDXTXVLGA 876
I A T VLGA
Sbjct: 217 ILHAKAAGKQPFMVAATAGTTVLGA 241
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 306,129,575
Number of Sequences: 1657284
Number of extensions: 2344941
Number of successful extensions: 1116
Number of sequences better than 10.0: 13
Number of HSP's better than 10.0 without gapping: 1111
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 1115
length of database: 575,637,011
effective HSP length: 101
effective length of database: 408,251,327
effective search space used: 88590537959
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
- SilkBase 1999-2023 -