Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fdpeP12_F_F10
(879 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_UPI00015B58C3 Cluster: PREDICTED: similar to topoisomer... 225 2e-57
UniRef50_Q171C3 Cluster: DNA topoisomerase; n=1; Aedes aegypti|R... 215 1e-54
UniRef50_UPI0000DB782E Cluster: PREDICTED: similar to topoisomer... 208 2e-52
UniRef50_Q9NG98 Cluster: DNA topoisomerase 3-alpha; n=6; Eukaryo... 205 1e-51
UniRef50_Q4SVN5 Cluster: DNA topoisomerase; n=3; Tetraodontidae|... 197 4e-49
UniRef50_Q13472 Cluster: DNA topoisomerase 3-alpha; n=32; Eumeta... 197 4e-49
UniRef50_Q9LVP1 Cluster: DNA topoisomerase; n=2; core eudicotyle... 161 2e-38
UniRef50_Q554F7 Cluster: DNA topoisomerase; n=2; Dictyostelium d... 141 2e-32
UniRef50_O61660 Cluster: DNA topoisomerase 3; n=2; Caenorhabditi... 137 4e-31
UniRef50_UPI000049A220 Cluster: DNA topoisomerase III; n=1; Enta... 133 5e-30
UniRef50_Q01CA7 Cluster: DNA topoisomerase III alpha, putative; ... 124 3e-27
UniRef50_Q7RQG4 Cluster: DNA topoisomerase iii; n=5; Plasmodium|... 116 6e-25
UniRef50_A0CUH3 Cluster: Chromosome undetermined scaffold_28, wh... 116 8e-25
UniRef50_Q8IDM7 Cluster: DNA topoisomerase III, putative; n=2; P... 113 4e-24
UniRef50_P13099 Cluster: DNA topoisomerase 3; n=6; Saccharomycet... 109 9e-23
UniRef50_Q55KM2 Cluster: DNA topoisomerase; n=2; Filobasidiella ... 107 3e-22
UniRef50_A7AMD4 Cluster: DNA topoisomerase family protein; n=1; ... 107 4e-22
UniRef50_A3FPU5 Cluster: DNA topoisomerase; n=3; Cryptosporidium... 106 8e-22
UniRef50_O60126 Cluster: DNA topoisomerase 3; n=1; Schizosacchar... 106 8e-22
UniRef50_Q4PAW5 Cluster: DNA topoisomerase; n=1; Ustilago maydis... 105 2e-21
UniRef50_UPI00006CAF66 Cluster: DNA topoisomerase family protein... 99 7e-20
UniRef50_Q24DD8 Cluster: DNA topoisomerase family protein; n=1; ... 99 1e-19
UniRef50_Q4Q199 Cluster: DNA topoisomerase III, putative; n=8; T... 97 7e-19
UniRef50_O95985 Cluster: DNA topoisomerase 3-beta-1; n=47; Eukar... 96 9e-19
UniRef50_UPI00004992C6 Cluster: DNA topoisomerase III; n=1; Enta... 94 4e-18
UniRef50_UPI00006CC0A9 Cluster: DNA topoisomerase family protein... 93 8e-18
UniRef50_UPI00006CA49A Cluster: DNA topoisomerase family protein... 93 8e-18
UniRef50_Q8S5U5 Cluster: DNA topoisomerase; n=3; Oryza sativa|Re... 93 8e-18
UniRef50_Q4Q888 Cluster: DNA topoisomerase III, putative; n=6; T... 91 3e-17
UniRef50_Q5ANG9 Cluster: Likely DNA topoisomerase III; n=5; Sacc... 91 3e-17
UniRef50_Q0U0G1 Cluster: DNA topoisomerase; n=14; Pezizomycotina... 91 3e-17
UniRef50_Q9SKZ9 Cluster: Putative DNA topoisomerase III beta; n=... 91 5e-17
UniRef50_A3FQH8 Cluster: DNA topoisomerase III, putative; n=3; C... 91 5e-17
UniRef50_A2DNF5 Cluster: DNA topoisomerase; n=2; Trichomonas vag... 90 8e-17
UniRef50_Q9U286 Cluster: DNA topoisomerase; n=2; Bilateria|Rep: ... 88 2e-16
UniRef50_A5BC76 Cluster: Putative uncharacterized protein; n=2; ... 88 3e-16
UniRef50_UPI0001509E74 Cluster: DNA topoisomerase family protein... 87 6e-16
UniRef50_Q016P5 Cluster: DNA topoisomerase; n=2; Eukaryota|Rep: ... 84 5e-15
UniRef50_A2Z2S2 Cluster: DNA topoisomerase; n=3; Oryza sativa|Re... 82 2e-14
UniRef50_Q6C0R0 Cluster: DNA topoisomerase; n=1; Yarrowia lipoly... 79 1e-13
UniRef50_A0DGW1 Cluster: DNA topoisomerase; n=1; Paramecium tetr... 78 3e-13
UniRef50_A4RZ61 Cluster: DNA topoisomerase; n=2; cellular organi... 78 3e-13
UniRef50_Q4UB92 Cluster: DNA topoisomerase iii, putative; n=2; T... 69 1e-10
UniRef50_A7AST5 Cluster: DNA topoisomerase, putative; n=1; Babes... 69 2e-10
UniRef50_Q7QZC9 Cluster: DNA topoisomerase; n=1; Giardia lamblia... 64 3e-09
UniRef50_Q2H6C2 Cluster: Putative uncharacterized protein; n=2; ... 63 8e-09
UniRef50_A7D4M8 Cluster: DNA topoisomerase; n=1; Halorubrum lacu... 61 3e-08
UniRef50_Q1AUL7 Cluster: DNA topoisomerase I; n=1; Rubrobacter x... 59 2e-07
UniRef50_Q64CK3 Cluster: DNA topoisomerase; n=1; uncultured arch... 55 2e-06
UniRef50_A1RYK6 Cluster: DNA topoisomerase; n=1; Thermofilum pen... 54 4e-06
UniRef50_UPI0000F1E09D Cluster: PREDICTED: similar to MGC53016 p... 53 1e-05
UniRef50_Q8TPW5 Cluster: DNA topoisomerase; n=3; Methanosarcina|... 51 4e-05
UniRef50_Q12Y06 Cluster: DNA topoisomerase; n=1; Methanococcoide... 51 4e-05
UniRef50_Q0W2I3 Cluster: DNA topoisomerase I; n=1; uncultured me... 50 6e-05
UniRef50_A5BX18 Cluster: Putative uncharacterized protein; n=1; ... 48 4e-04
UniRef50_A7I6L6 Cluster: DNA topoisomerase; n=1; Candidatus Meth... 47 7e-04
UniRef50_Q8SS31 Cluster: DNA TOPOISOMERASE III; n=1; Encephalito... 44 0.004
UniRef50_Q33E26 Cluster: DNA topoisomerase; n=1; Enterococcus fa... 44 0.007
UniRef50_A2SSK2 Cluster: DNA topoisomerase; n=3; Methanomicrobia... 44 0.007
UniRef50_UPI0001555C8D Cluster: PREDICTED: similar to topoisomer... 41 0.048
UniRef50_Q7QZE9 Cluster: GLP_43_17393_20314; n=1; Giardia lambli... 40 0.063
UniRef50_A7NJW2 Cluster: DNA topoisomerase I; n=2; Chloroflexace... 39 0.15
UniRef50_Q48NI0 Cluster: DNA topoisomerase III; n=1; Pseudomonas... 36 1.8
UniRef50_O87222 Cluster: DNA topoisomerase; n=21; Firmicutes|Rep... 36 1.8
UniRef50_Q98RZ5 Cluster: Putative uncharacterized protein orf419... 36 1.8
UniRef50_Q4AA55 Cluster: DNA topoisomerase I; n=5; Mycoplasma hy... 35 2.4
UniRef50_O13290 Cluster: Dynein heavy chain, cytosolic; n=1; Sch... 35 2.4
UniRef50_A6DDI1 Cluster: DNA topoisomerase I; n=1; Caminibacter ... 35 3.1
UniRef50_P34185 Cluster: DNA topoisomerase 1; n=23; Cyanobacteri... 35 3.1
UniRef50_Q6MP96 Cluster: DNA topoisomerase I; n=4; Bacteria|Rep:... 34 4.1
UniRef50_Q98Q95 Cluster: DNA TOPOISOMERASE I; n=2; Mycoplasma|Re... 34 5.5
UniRef50_A6RLG6 Cluster: Putative uncharacterized protein; n=2; ... 34 5.5
UniRef50_Q4FM27 Cluster: TrkH-like cation transport protein; n=2... 33 7.2
UniRef50_P74600 Cluster: Slr1568 protein; n=1; Synechocystis sp.... 33 7.2
UniRef50_A6C5M1 Cluster: DNA topoisomerase; n=1; Planctomyces ma... 33 7.2
UniRef50_A0CP28 Cluster: Chromosome undetermined scaffold_23, wh... 33 7.2
UniRef50_O51768 Cluster: DNA topoisomerase 1; n=3; Borrelia burg... 33 7.2
UniRef50_Q5EP76 Cluster: TopB; n=1; Neisseria gonorrhoeae|Rep: T... 33 9.6
UniRef50_Q9LPA7 Cluster: T32E20.13; n=1; Arabidopsis thaliana|Re... 33 9.6
UniRef50_Q8I452 Cluster: Putative uncharacterized protein PFE024... 33 9.6
>UniRef50_UPI00015B58C3 Cluster: PREDICTED: similar to topoisomerase
III alpha; n=1; Nasonia vitripennis|Rep: PREDICTED:
similar to topoisomerase III alpha - Nasonia vitripennis
Length = 1078
Score = 225 bits (549), Expect = 2e-57
Identities = 105/159 (66%), Positives = 126/159 (79%), Gaps = 1/159 (0%)
Frame = +3
Query: 405 MKYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHL 584
MK LNVAEKNDAAKNIA +LS+GTS R+EGLS YNKIY+F++ + +DC+M+MTSVSGHL
Sbjct: 1 MKVLNVAEKNDAAKNIAGYLSRGTSRRKEGLSPYNKIYEFQSRLWNKDCQMIMTSVSGHL 60
Query: 585 LALEFSGTYRTWQTCSPLSLFDAPVFKYC-PENYQKIKMTLEREVRSCQGLIIWTDCDRE 761
L EF+G YR W C PLSLF+APV K C +NY+KIK T+EREVRSC LIIWTDCDRE
Sbjct: 61 LNYEFTGAYRKWYGCPPLSLFEAPVVKQCQQDNYEKIKKTIEREVRSCSALIIWTDCDRE 120
Query: 762 GENIGFEIIDVCKXCQDKFENI*SKXSEITLVSVNRALQ 878
GENIGFEII VC+ + +K SEIT +S++RALQ
Sbjct: 121 GENIGFEIIQVCQAVKPNIRVYRAKFSEITQISIDRALQ 159
>UniRef50_Q171C3 Cluster: DNA topoisomerase; n=1; Aedes aegypti|Rep:
DNA topoisomerase - Aedes aegypti (Yellowfever mosquito)
Length = 1021
Score = 215 bits (525), Expect = 1e-54
Identities = 103/160 (64%), Positives = 121/160 (75%)
Frame = +3
Query: 399 STMKYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSG 578
+ MKYLNVAEKNDAAKNIA LS+G+S RREG S YNKIY+F N+ GQ +MVMTSVSG
Sbjct: 23 AVMKYLNVAEKNDAAKNIAGLLSRGSSQRREGYSPYNKIYEFSYNIRGQPVQMVMTSVSG 82
Query: 579 HLLALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDR 758
HLL EF ++R W +C+P LFDAPV K C EN KIK TLEREVR CQ L+IWTDCDR
Sbjct: 83 HLLNYEFLPSFRGWHSCNPEQLFDAPVRKSCTENMGKIKQTLEREVRGCQTLVIWTDCDR 142
Query: 759 EGENIGFEIIDVCKXCQDKFENI*SKXSEITLVSVNRALQ 878
EGENIGFEII+VC+ + + +K SEIT SV RA++
Sbjct: 143 EGENIGFEIIEVCRAIKPGIRVLRAKFSEITAASVKRAVE 182
>UniRef50_UPI0000DB782E Cluster: PREDICTED: similar to topoisomerase
(DNA) III alpha; n=2; Endopterygota|Rep: PREDICTED:
similar to topoisomerase (DNA) III alpha - Apis
mellifera
Length = 958
Score = 208 bits (507), Expect = 2e-52
Identities = 101/159 (63%), Positives = 118/159 (74%), Gaps = 1/159 (0%)
Frame = +3
Query: 405 MKYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHL 584
M LNVAEKNDAAKNIA +LS+GT RREGL YNKI++F + + ++C M+MTSVSGHL
Sbjct: 1 MNVLNVAEKNDAAKNIAAYLSRGTYKRREGLWLYNKIFEFNSYLWNKNCHMIMTSVSGHL 60
Query: 585 LALEFSGTYRTWQTCSPLSLFDAPVFKYC-PENYQKIKMTLEREVRSCQGLIIWTDCDRE 761
L EF G YR WQ+C PLSLFDAPV K C E+ KIK TLE+EV+ C LIIWTDCDRE
Sbjct: 61 LNCEFVGIYRKWQSCHPLSLFDAPVVKQCSQESSIKIKKTLEKEVQKCNALIIWTDCDRE 120
Query: 762 GENIGFEIIDVCKXCQDKFENI*SKXSEITLVSVNRALQ 878
GENIGFEII VC+ + +K SEIT SVNR+LQ
Sbjct: 121 GENIGFEIIQVCRAIKPNIRIYRAKFSEITQTSVNRSLQ 159
>UniRef50_Q9NG98 Cluster: DNA topoisomerase 3-alpha; n=6;
Eukaryota|Rep: DNA topoisomerase 3-alpha - Drosophila
melanogaster (Fruit fly)
Length = 1250
Score = 205 bits (501), Expect = 1e-51
Identities = 100/169 (59%), Positives = 121/169 (71%)
Frame = +3
Query: 372 NKQIFVNKYSTMKYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDC 551
+++ N MKYLNVAEKNDAAK IA LS G + RREG S YNK++ F+A V GQ+
Sbjct: 15 HRRYCANPGQAMKYLNVAEKNDAAKTIAGLLSNGAAQRREGYSVYNKVFDFEAPVRGQNA 74
Query: 552 EMVMTSVSGHLLALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQG 731
+MVMTSVSGH++ L F +Y+ W+T P SLFDAPV K +Y+ IK TLEREVR CQG
Sbjct: 75 KMVMTSVSGHMMQLAFQVSYKNWRTVDPRSLFDAPVKKGVGSDYEPIKRTLEREVRGCQG 134
Query: 732 LIIWTDCDREGENIGFEIIDVCKXCQDKFENI*SKXSEITLVSVNRALQ 878
LIIWTDCDREGENIG+EIIDVC+ + + SEIT V+V RALQ
Sbjct: 135 LIIWTDCDREGENIGYEIIDVCRAIKPNISVYRATFSEITTVAVRRALQ 183
>UniRef50_Q4SVN5 Cluster: DNA topoisomerase; n=3;
Tetraodontidae|Rep: DNA topoisomerase - Tetraodon
nigroviridis (Green puffer)
Length = 984
Score = 197 bits (480), Expect = 4e-49
Identities = 91/155 (58%), Positives = 118/155 (76%)
Frame = +3
Query: 408 KYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHLL 587
+ L VAEKNDAAK I+ +S G RREG+SK+NKIY+F+ +++GQ+ + MTSVSGHLL
Sbjct: 10 RVLCVAEKNDAAKGISEIMSNGRFRRREGMSKFNKIYEFEYHLLGQNVTVAMTSVSGHLL 69
Query: 588 ALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDREGE 767
ALEF ++ W +C+P+ LFDA V KYCP+N +IK TLE+EV+ CQ L+IWTDCDREGE
Sbjct: 70 ALEFKAPFQKWHSCNPVILFDAEVEKYCPDNMVQIKRTLEKEVKQCQLLVIWTDCDREGE 129
Query: 768 NIGFEIIDVCKXCQDKFENI*SKXSEITLVSVNRA 872
NIGFEIIDVCK + + + +K SEIT S+ RA
Sbjct: 130 NIGFEIIDVCKAVKSNIQVLRAKFSEITPNSIRRA 164
>UniRef50_Q13472 Cluster: DNA topoisomerase 3-alpha; n=32;
Eumetazoa|Rep: DNA topoisomerase 3-alpha - Homo sapiens
(Human)
Length = 1001
Score = 197 bits (480), Expect = 4e-49
Identities = 95/157 (60%), Positives = 115/157 (73%)
Frame = +3
Query: 408 KYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHLL 587
K L VAEKNDAAK IA LS G RREGLSK+NKIY+F ++ GQ+ MVMTSVSGHLL
Sbjct: 35 KVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLL 94
Query: 588 ALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDREGE 767
A +F +R WQ+C+PL LF+A + KYCPEN+ IK TLERE R CQ L+IWTDCDREGE
Sbjct: 95 AHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGE 154
Query: 768 NIGFEIIDVCKXCQDKFENI*SKXSEITLVSVNRALQ 878
NIGFEII VCK + + + ++ SEIT +V A +
Sbjct: 155 NIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACE 191
>UniRef50_Q9LVP1 Cluster: DNA topoisomerase; n=2; core
eudicotyledons|Rep: DNA topoisomerase - Arabidopsis
thaliana (Mouse-ear cress)
Length = 926
Score = 161 bits (391), Expect = 2e-38
Identities = 71/129 (55%), Positives = 91/129 (70%)
Frame = +3
Query: 414 LNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHLLAL 593
LNVAEK AK++A LS+GT REG S+YNKI++F + GQ C M+MTSV GHL+ L
Sbjct: 12 LNVAEKPSVAKSVAGILSRGTFRTREGRSRYNKIFEFDYAINGQPCRMLMTSVIGHLMEL 71
Query: 594 EFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDREGENI 773
EF+ YR W +C P L+ APV K+ PE+ + IK TLE E R L++W DCDREGENI
Sbjct: 72 EFADRYRKWHSCDPADLYQAPVMKHVPEDKKDIKKTLEEEARKSDWLVLWLDCDREGENI 131
Query: 774 GFEIIDVCK 800
FE++DVC+
Sbjct: 132 AFEVVDVCR 140
>UniRef50_Q554F7 Cluster: DNA topoisomerase; n=2; Dictyostelium
discoideum|Rep: DNA topoisomerase - Dictyostelium
discoideum AX4
Length = 853
Score = 141 bits (341), Expect = 2e-32
Identities = 61/131 (46%), Positives = 88/131 (67%), Gaps = 1/131 (0%)
Frame = +3
Query: 483 RREGLSKYNKIYQFKANVMG-QDCEMVMTSVSGHLLALEFSGTYRTWQTCSPLSLFDAPV 659
+REG SKYNK++ FK N++ DCEM TSV+GHL+ ++ ++ W +C P+ LFDAP+
Sbjct: 54 KREGFSKYNKLWDFKYNILNFNDCEMTFTSVTGHLMEIDVVEQFKPWASCDPIQLFDAPI 113
Query: 660 FKYCPENYQKIKMTLEREVRSCQGLIIWTDCDREGENIGFEIIDVCKXCQDKFENI*SKX 839
K P + + +K TLERE++ LI+W DCDREGENI FE+++VCK + KFE +
Sbjct: 114 RKTVPSDKEPLKKTLEREIKKADILILWLDCDREGENIAFEVLEVCKNAKKKFEFYRAHF 173
Query: 840 SEITLVSVNRA 872
S I ++RA
Sbjct: 174 SAIIPREIDRA 184
>UniRef50_O61660 Cluster: DNA topoisomerase 3; n=2;
Caenorhabditis|Rep: DNA topoisomerase 3 - Caenorhabditis
elegans
Length = 759
Score = 137 bits (331), Expect = 4e-31
Identities = 67/153 (43%), Positives = 91/153 (59%)
Frame = +3
Query: 414 LNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHLLAL 593
L VAEKND AK +A LS GT+ RREG SK+NKIY + GQ + +TSVSGH++
Sbjct: 5 LFVAEKNDVAKGVAAILSNGTANRREGRSKFNKIYTLNTELFGQQTAISVTSVSGHMMNF 64
Query: 594 EFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDREGENI 773
+F WQT S + LF APV + I+ TL + + L++WTDCDREGE I
Sbjct: 65 QFHENMSNWQTASMVELFRAPVRHVVTPEMKLIEQTLREQAQRHDILVVWTDCDREGEAI 124
Query: 774 GFEIIDVCKXCQDKFENI*SKXSEITLVSVNRA 872
G EI+ VC+ + + ++ SEIT ++ RA
Sbjct: 125 GAEIVKVCRDSNRRLDIFRARFSEITKAAITRA 157
>UniRef50_UPI000049A220 Cluster: DNA topoisomerase III; n=1;
Entamoeba histolytica HM-1:IMSS|Rep: DNA topoisomerase
III - Entamoeba histolytica HM-1:IMSS
Length = 607
Score = 133 bits (322), Expect = 5e-30
Identities = 59/137 (43%), Positives = 85/137 (62%), Gaps = 1/137 (0%)
Frame = +3
Query: 414 LNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQD-CEMVMTSVSGHLLA 590
L+VAEK A I+ LS+GT + GLSKYN ++ F+ C +TSV+GHL
Sbjct: 5 LHVAEKPSVASAISYTLSRGTCKKTPGLSKYNSVFSFEHEFKNDGKCTHYVTSVAGHLKG 64
Query: 591 LEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDREGEN 770
++F+ YR+W +C P LF AP+ K P N +K+++ L+ + CQ L++W DCDREGEN
Sbjct: 65 IDFTTAYRSWGSCDPEELFTAPIEKSVPSNMKKVELNLKSLAKKCQVLVLWLDCDREGEN 124
Query: 771 IGFEIIDVCKXCQDKFE 821
I FE+I+VC K +
Sbjct: 125 ISFEVIEVCSEVNSKMK 141
>UniRef50_Q01CA7 Cluster: DNA topoisomerase III alpha, putative;
n=2; Ostreococcus|Rep: DNA topoisomerase III alpha,
putative - Ostreococcus tauri
Length = 842
Score = 124 bits (299), Expect = 3e-27
Identities = 64/158 (40%), Positives = 94/158 (59%), Gaps = 2/158 (1%)
Frame = +3
Query: 408 KYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHLL 587
+ LNVAEK AK I+ LS GT+ REG + +NK+++F+ V G+ MV TSV+GHL
Sbjct: 6 RVLNVAEKPSVAKEISRVLSNGTARVREGATAWNKVWEFEHVVRGRPVTMVFTSVTGHLS 65
Query: 588 ALEFSGT-YRTWQTCSPLSLF-DAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDRE 761
EF+ +R W + P L DA V K PE+ +K ++RE R C +I+W DCDRE
Sbjct: 66 NFEFAEERHRRWASVDPRELLVDARVVKRVPEDKRKTAENVKREARGCDTVILWLDCDRE 125
Query: 762 GENIGFEIIDVCKXCQDKFENI*SKXSEITLVSVNRAL 875
GENI FE+++ C+ + + ++ S + +RAL
Sbjct: 126 GENIAFEVLEACRQAKPGITALRARFSALGRGDADRAL 163
>UniRef50_Q7RQG4 Cluster: DNA topoisomerase iii; n=5;
Plasmodium|Rep: DNA topoisomerase iii - Plasmodium
yoelii yoelii
Length = 677
Score = 116 bits (280), Expect = 6e-25
Identities = 57/157 (36%), Positives = 87/157 (55%)
Frame = +3
Query: 405 MKYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHL 584
+K LNVAEK A I LSKG S +++ SKYN ++ F + + M +TSV+GHL
Sbjct: 4 IKVLNVAEKPSVASAIVSILSKGKSNKKKSYSKYNPVFTFDYKMENETWSMFVTSVTGHL 63
Query: 585 LALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDREG 764
+F Y+ W P LFDA + Y ++ + I+ L++ + C LI+W DCDREG
Sbjct: 64 TDQKFDDKYKNWNNTDPHELFDAKITIYIDKDKKPIENNLKKYSKDCNVLILWLDCDREG 123
Query: 765 ENIGFEIIDVCKXCQDKFENI*SKXSEITLVSVNRAL 875
E+I FE+I+ C K + ++ S +T + A+
Sbjct: 124 EHICFEVINACSVTNKKLKIHRAQFSAVTEKDIKYAI 160
>UniRef50_A0CUH3 Cluster: Chromosome undetermined scaffold_28, whole
genome shotgun sequence; n=3; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_28,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 947
Score = 116 bits (279), Expect = 8e-25
Identities = 59/162 (36%), Positives = 93/162 (57%), Gaps = 1/162 (0%)
Frame = +3
Query: 393 KYSTMKYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSV 572
K+ +K LNVAEK A++IA L++ T E S YNK+++F Q+ EM +TSV
Sbjct: 9 KFGKIKVLNVAEKPSVARSIANVLARD-HTVEETQSPYNKLFKFNFKFGDQEVEMWITSV 67
Query: 573 SGHLLALEFSGTYRTWQTCSPLSLF-DAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTD 749
+GHL +L + Y+ W P+ + DA + P + ++ L++ R C LI+W D
Sbjct: 68 TGHLKSLRYPKQYQKWDQWDPIIILKDAEIENIIPNEKRFLEGNLKQFARECSQLILWLD 127
Query: 750 CDREGENIGFEIIDVCKXCQDKFENI*SKXSEITLVSVNRAL 875
CDREGENI FE+++VCK + + + S +T + + +AL
Sbjct: 128 CDREGENIAFEVLEVCKDSNPQIQVHRAHFSAVTYIDIKKAL 169
>UniRef50_Q8IDM7 Cluster: DNA topoisomerase III, putative; n=2;
Plasmodium|Rep: DNA topoisomerase III, putative -
Plasmodium falciparum (isolate 3D7)
Length = 710
Score = 113 bits (273), Expect = 4e-24
Identities = 54/137 (39%), Positives = 78/137 (56%)
Frame = +3
Query: 405 MKYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHL 584
+K LNVAEK A +IA LSKG + + SKYN ++ F + M +TSV+GHL
Sbjct: 4 LKVLNVAEKPSVASSIAEILSKGRPNKIKSCSKYNPVFTFDYKIKNDIWYMYVTSVTGHL 63
Query: 585 LALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDREG 764
+F Y+ W P LFDA + Y ++ + I+ L++ + C LI+W DCDREG
Sbjct: 64 TDQKFDDRYKNWHNTDPQELFDAEITVYVEKDKKNIENNLKKYSKECNMLILWLDCDREG 123
Query: 765 ENIGFEIIDVCKXCQDK 815
E+I FE+I+ C+ K
Sbjct: 124 EHICFEVINACRITNRK 140
>UniRef50_P13099 Cluster: DNA topoisomerase 3; n=6;
Saccharomycetales|Rep: DNA topoisomerase 3 -
Saccharomyces cerevisiae (Baker's yeast)
Length = 656
Score = 109 bits (262), Expect = 9e-23
Identities = 59/132 (44%), Positives = 77/132 (58%), Gaps = 5/132 (3%)
Frame = +3
Query: 405 MKYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVM-----GQDCEMVMTS 569
MK L VAEKN AK ++ L G ST R+ Y K Y F + G +CE+ MTS
Sbjct: 1 MKVLCVAEKNSIAKAVSQILGGGRSTSRDSGYMYVKNYDFMFSGFPFARNGANCEVTMTS 60
Query: 570 VSGHLLALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTD 749
V+GHL ++FS W C+ LFDAP+ + N +KI ++RE R+ L+IWTD
Sbjct: 61 VAGHLTGIDFSHDSHGWGKCAIQELFDAPLNEIMNNNQKKIASNIKREARNADYLMIWTD 120
Query: 750 CDREGENIGFEI 785
CDREGE IG+EI
Sbjct: 121 CDREGEYIGWEI 132
>UniRef50_Q55KM2 Cluster: DNA topoisomerase; n=2; Filobasidiella
neoformans|Rep: DNA topoisomerase - Cryptococcus
neoformans (Filobasidiella neoformans)
Length = 1059
Score = 107 bits (258), Expect = 3e-22
Identities = 54/137 (39%), Positives = 78/137 (56%), Gaps = 5/137 (3%)
Frame = +3
Query: 405 MKYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVM-----GQDCEMVMTS 569
M+ L VAEK AK+I LS G R G +Y + Y F N+ G+ +T+
Sbjct: 1 MRVLCVAEKPSIAKSITEILSGGRWDTRNGRHQYIRNYDFLYNLAPPLGNGRGANFTVTA 60
Query: 570 VSGHLLALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTD 749
V GHL + +F +R W +C P +LFDAPV + + + ++ L+ E R+ L+IWTD
Sbjct: 61 VLGHLTSSDFDDDHRKWGSCDPFALFDAPVITFVDQKLKTVESNLQIEARNADILMIWTD 120
Query: 750 CDREGENIGFEIIDVCK 800
CDREGE+IG E++ CK
Sbjct: 121 CDREGEHIGSEVVAACK 137
>UniRef50_A7AMD4 Cluster: DNA topoisomerase family protein; n=1;
Babesia bovis|Rep: DNA topoisomerase family protein -
Babesia bovis
Length = 633
Score = 107 bits (257), Expect = 4e-22
Identities = 52/129 (40%), Positives = 73/129 (56%)
Frame = +3
Query: 414 LNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHLLAL 593
LNVAEK A++I+ LS G ++ N +Y F A + G+ C+M TSV GHL+ +
Sbjct: 5 LNVAEKPSVARSISDILSGGRMRSEMSNARTNPVYSFTAPLEGRHCKMYFTSVRGHLMEI 64
Query: 594 EFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDREGENI 773
+F YR WQ SLF AP+ N + I+ L R C L++W DCDREGE I
Sbjct: 65 DFDARYRNWQRTPIESLFCAPIQAAVSSNCKDIEKNLLHYARMCSKLVLWLDCDREGEAI 124
Query: 774 GFEIIDVCK 800
+E++ VC+
Sbjct: 125 AYEVMAVCQ 133
>UniRef50_A3FPU5 Cluster: DNA topoisomerase; n=3;
Cryptosporidium|Rep: DNA topoisomerase - Cryptosporidium
parvum Iowa II
Length = 835
Score = 106 bits (254), Expect = 8e-22
Identities = 53/132 (40%), Positives = 79/132 (59%)
Frame = +3
Query: 399 STMKYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSG 578
S +K L VAEK + I+ LS G R G + +++F MG + + +TSV+G
Sbjct: 2 SPIKVLMVAEKPSISDTISRILSNGKLDTRRGKTP---VHEFNGTFMGMNVQFRVTSVAG 58
Query: 579 HLLALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDR 758
H+ ++F +Y W+ P+SLFDAP+ K E+ K+ LE+E + C L++W DCDR
Sbjct: 59 HVFEIDFPQSYSNWEKTDPVSLFDAPIIK--NESSSKMVSHLEKESKGCSYLVLWLDCDR 116
Query: 759 EGENIGFEIIDV 794
EGENI FE+I+V
Sbjct: 117 EGENICFEVINV 128
>UniRef50_O60126 Cluster: DNA topoisomerase 3; n=1;
Schizosaccharomyces pombe|Rep: DNA topoisomerase 3 -
Schizosaccharomyces pombe (Fission yeast)
Length = 622
Score = 106 bits (254), Expect = 8e-22
Identities = 57/134 (42%), Positives = 76/134 (56%), Gaps = 2/134 (1%)
Frame = +3
Query: 405 MKYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQ--DCEMVMTSVSG 578
M+ L VAEKN AK++A L G RR+ SKY K Y F N G ++ MTSVSG
Sbjct: 1 MRVLCVAEKNSIAKSVASILGGGHVRRRDTRSKYVKNYDFSFNFGGNVGSSDVTMTSVSG 60
Query: 579 HLLALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDR 758
HL F Y +W + LFDA + +N + + +++E R+ Q L IWTDCDR
Sbjct: 61 HLTEASFPSEYSSWSSVPQDVLFDAQIITSVSKNAEVLADNIKKEARNAQYLYIWTDCDR 120
Query: 759 EGENIGFEIIDVCK 800
EGE+IG EI +V +
Sbjct: 121 EGEHIGVEISNVAR 134
>UniRef50_Q4PAW5 Cluster: DNA topoisomerase; n=1; Ustilago
maydis|Rep: DNA topoisomerase - Ustilago maydis (Smut
fungus)
Length = 1325
Score = 105 bits (251), Expect = 2e-21
Identities = 57/160 (35%), Positives = 87/160 (54%), Gaps = 2/160 (1%)
Frame = +3
Query: 405 MKYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQD--CEMVMTSVSG 578
M+ L VAEK AK+IA L++G ++ R G K+ + Y F+ + G +M MTSV G
Sbjct: 96 MRILCVAEKPSIAKSIANILARGHASNRPGKDKFCRNYDFQYRMPGVQGMVDMTMTSVRG 155
Query: 579 HLLALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDR 758
HL +F ++ W +C P LF APV ++ + I L E R+ ++IWTDCDR
Sbjct: 156 HLTNTDFGPQHKAWFSCPPADLFQAPVITNLSDDAKDIGTNLRLEARNADAVMIWTDCDR 215
Query: 759 EGENIGFEIIDVCKXCQDKFENI*SKXSEITLVSVNRALQ 878
EGE+IG EI+ + + + ++ S I ++ A Q
Sbjct: 216 EGEHIGSEIVAEVRKVRRNIRVMRARFSAIIDSQIHAACQ 255
>UniRef50_UPI00006CAF66 Cluster: DNA topoisomerase family protein;
n=1; Tetrahymena thermophila SB210|Rep: DNA
topoisomerase family protein - Tetrahymena thermophila
SB210
Length = 1386
Score = 99 bits (238), Expect = 7e-20
Identities = 54/161 (33%), Positives = 88/161 (54%), Gaps = 3/161 (1%)
Frame = +3
Query: 399 STMKYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSG 578
S + L VAEK A++IA L T R+G+ K++ ++ F ++ G+ + +TSV G
Sbjct: 240 SFVTVLMVAEKPSIARSIAEALGGAGFTTRKGICKFSNVFTFYGHIFGKKALIKVTSVIG 299
Query: 579 HLLALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDR 758
H+ +F+ Y+ W+ P LF+A K +I L++E LI+W D DR
Sbjct: 300 HIYTSDFTQEYQDWRRVDPYKLFNATTLKKETNPNSQIIQHLQKEAMGASYLILWLDNDR 359
Query: 759 EGENIGFEIIDVCK--XCQDKFENI-*SKXSEITLVSVNRA 872
EGENI FE++ +CK ++ F+ I +K S IT + + +A
Sbjct: 360 EGENICFEVLTICKPELIKEDFQQIFRAKFSSITPIDIRKA 400
>UniRef50_Q24DD8 Cluster: DNA topoisomerase family protein; n=1;
Tetrahymena thermophila SB210|Rep: DNA topoisomerase
family protein - Tetrahymena thermophila SB210
Length = 1374
Score = 99.1 bits (236), Expect = 1e-19
Identities = 51/139 (36%), Positives = 76/139 (54%)
Frame = +3
Query: 408 KYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHLL 587
K + +AEK AK+IA LS +S +G SKY +++F+ G +TSV+GH+
Sbjct: 536 KVVMIAEKPSIAKSIADALSNNSSKSVKGYSKYLPVHEFEGQFKGNRVLFKVTSVAGHVY 595
Query: 588 ALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDREGE 767
+L+F Y W +P++LF A K Q + LE+E + LI+W D DREGE
Sbjct: 596 SLDFQKEYDQWNKVNPINLFSAKTIKVEANPSQGVVKHLEKEAQDASYLILWLDNDREGE 655
Query: 768 NIGFEIIDVCKXCQDKFEN 824
NI FE+ +C+ K +N
Sbjct: 656 NICFEVKSICEAFMCKEQN 674
>UniRef50_Q4Q199 Cluster: DNA topoisomerase III, putative; n=8;
Trypanosomatidae|Rep: DNA topoisomerase III, putative -
Leishmania major
Length = 947
Score = 96.7 bits (230), Expect = 7e-19
Identities = 51/128 (39%), Positives = 72/128 (56%)
Frame = +3
Query: 411 YLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHLLA 590
+LNVAEK AK +A LS G S++N +Y+FK G+ M++TSV+GHL+
Sbjct: 4 WLNVAEKPSVAKEMAQSLSGGNCRTVPSQSRFNPVYEFKFE--GKT--MLVTSVAGHLME 59
Query: 591 LEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDREGEN 770
+F + W T LF AP+ KY + + +K LE L++W DCDREGEN
Sbjct: 60 DQFPPNTKNWSTYPFQGLFSAPITKYVRADLEPVKKNLEALAGRADTLVLWLDCDREGEN 119
Query: 771 IGFEIIDV 794
I FE++ V
Sbjct: 120 ICFEVMQV 127
>UniRef50_O95985 Cluster: DNA topoisomerase 3-beta-1; n=47;
Eukaryota|Rep: DNA topoisomerase 3-beta-1 - Homo sapiens
(Human)
Length = 862
Score = 96.3 bits (229), Expect = 9e-19
Identities = 52/137 (37%), Positives = 75/137 (54%), Gaps = 3/137 (2%)
Frame = +3
Query: 414 LNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHLLAL 593
L VAEK A++IA LS+G+ + +GL+ ++++ GQ MTSV GH++ L
Sbjct: 5 LMVAEKPSLAQSIAKILSRGSLSSHKGLNGACSVHEYTGTFAGQPVRFKMTSVCGHVMTL 64
Query: 594 EFSGTYRTWQTCSPLSLF-DAPVFKYCPENYQKIKMT--LEREVRSCQGLIIWTDCDREG 764
+F G Y W P LF AP K E K+ M L+ E R C +++W DCD+EG
Sbjct: 65 DFLGKYNKWDKVDPAELFSQAPTEK--KEANPKLNMVKFLQVEGRGCDYIVLWLDCDKEG 122
Query: 765 ENIGFEIIDVCKXCQDK 815
ENI FE++D +K
Sbjct: 123 ENICFEVLDAVLPVMNK 139
>UniRef50_UPI00004992C6 Cluster: DNA topoisomerase III; n=1;
Entamoeba histolytica HM-1:IMSS|Rep: DNA topoisomerase
III - Entamoeba histolytica HM-1:IMSS
Length = 840
Score = 94.3 bits (224), Expect = 4e-18
Identities = 49/129 (37%), Positives = 68/129 (52%)
Frame = +3
Query: 405 MKYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHL 584
M L VAEK A++IA LS G R+G++ +++F G+ + MTSV+GH+
Sbjct: 1 MTLLMVAEKPFLAESIAKFLSLGPIHTRKGIAPSCLVHEFNCKFKGKITKAKMTSVAGHV 60
Query: 585 LALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDREG 764
EF ++ W P LF V K +I L E C GL++W DCDREG
Sbjct: 61 YTCEFERAFQNWSV-DPRDLFSCNVIKVEANPKTRIPAHLRNEANGCNGLVLWLDCDREG 119
Query: 765 ENIGFEIID 791
ENI FE++D
Sbjct: 120 ENICFEVMD 128
>UniRef50_UPI00006CC0A9 Cluster: DNA topoisomerase family protein;
n=1; Tetrahymena thermophila SB210|Rep: DNA
topoisomerase family protein - Tetrahymena thermophila
SB210
Length = 1049
Score = 93.1 bits (221), Expect = 8e-18
Identities = 45/125 (36%), Positives = 71/125 (56%), Gaps = 2/125 (1%)
Frame = +3
Query: 414 LNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHLLAL 593
LNVAEK AK I+ L G+ + SKYN ++QF+ + + M+ TSV+GHL++
Sbjct: 5 LNVAEKPSVAKEISRVLGNGSQKTLDSESKYNPVFQFEYKLKQEQVNMLFTSVTGHLISQ 64
Query: 594 EFSGTYRTWQTCSPLSLFD--APVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDREGE 767
+F ++ W++ +P L D + + K+ + I+ L + R LI+W DCDREGE
Sbjct: 65 KFDDKFKNWKSFNPSVLLDQSSEILKFVESDKISIQRNLIKWARQVDTLILWLDCDREGE 124
Query: 768 NIGFE 782
I +E
Sbjct: 125 AIAYE 129
>UniRef50_UPI00006CA49A Cluster: DNA topoisomerase family protein;
n=1; Tetrahymena thermophila SB210|Rep: DNA
topoisomerase family protein - Tetrahymena thermophila
SB210
Length = 916
Score = 93.1 bits (221), Expect = 8e-18
Identities = 52/153 (33%), Positives = 81/153 (52%), Gaps = 2/153 (1%)
Frame = +3
Query: 348 NRTLCFLVNKQIFVNKYSTMK-YLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQF 524
N C+ I+ K ++ L VAEK A+ IA LS TS +R+G +Y +Y +
Sbjct: 185 NEDKCYNETYNIYSGKKGQIQEVLLVAEKPSVARKIASALSNKTSKKRQGKVRYLPVYVY 244
Query: 525 KANVMGQDCEMVMTSVSGHLLALEFSGTYR-TWQTCSPLSLFDAPVFKYCPENYQKIKMT 701
+ GQ +TSV+GH+ L+F + W +P+ LF + K P + ++
Sbjct: 245 EGRFKGQKTIFKVTSVTGHVYDLDFPQKLKENWNEINPVQLFSSDTLK-IPSKHNIVR-H 302
Query: 702 LEREVRSCQGLIIWTDCDREGENIGFEIIDVCK 800
LE E R+C L++W D D+EGENI FE+ +C+
Sbjct: 303 LESEARNCSYLLLWLDNDKEGENICFEVKQICE 335
>UniRef50_Q8S5U5 Cluster: DNA topoisomerase; n=3; Oryza sativa|Rep:
DNA topoisomerase - Oryza sativa subsp. japonica (Rice)
Length = 912
Score = 93.1 bits (221), Expect = 8e-18
Identities = 48/122 (39%), Positives = 71/122 (58%), Gaps = 9/122 (7%)
Frame = +3
Query: 405 MKYLNVAEKNDAAKNIALHLSK--GTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSG 578
++ LNVAEK AK++A LS+ G REG S+YN++++F ++ G+ C M++TSV+G
Sbjct: 10 IRVLNVAEKPSVAKSVAEILSRPSGGMRSREGRSRYNRVFEFDYSIGGRACHMLVTSVTG 69
Query: 579 HLLALEFSGTYRTWQTCSPLSLFDAPVFKYCP------ENYQKIKMTLEREV-RSCQGLI 737
HL+ LEF +R W +C P LF APV K P E Y ++ L+R C +
Sbjct: 70 HLMELEFDDRFRRWHSCDPADLFHAPVRKSVPQGTALKELYSRVLQELDRGTSHDCYSFL 129
Query: 738 IW 743
W
Sbjct: 130 NW 131
Score = 66.5 bits (155), Expect = 8e-10
Identities = 28/65 (43%), Positives = 40/65 (61%)
Frame = +3
Query: 684 QKIKMTLEREVRSCQGLIIWTDCDREGENIGFEIIDVCKXCQDKFENI*SKXSEITLVSV 863
Q IK TLE E R CQ L++W DCDREGENI +E+ID+C + ++ S + +
Sbjct: 203 QDIKRTLEEEARKCQWLVLWLDCDREGENIAYEVIDICAGANSRLNIWRARFSALIDREI 262
Query: 864 NRALQ 878
+ A+Q
Sbjct: 263 HEAVQ 267
>UniRef50_Q4Q888 Cluster: DNA topoisomerase III, putative; n=6;
Trypanosomatidae|Rep: DNA topoisomerase III, putative -
Leishmania major
Length = 866
Score = 91.5 bits (217), Expect = 3e-17
Identities = 46/129 (35%), Positives = 72/129 (55%)
Frame = +3
Query: 414 LNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHLLAL 593
L VAEK A++IA LS G+ +RR ++ +Y++ N MG +TS +GH+ +
Sbjct: 6 LMVAEKPSLAESIATILSNGSCSRR---TRALPVYEYPGNFMGSPAYFKVTSTTGHVFSC 62
Query: 594 EFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDREGENI 773
+F+ ++ W LF AP+ + K+ LE E + C L++W DCDREGENI
Sbjct: 63 DFTSQHQNWDRTDEEQLFTAPIT--WKDTSGKVTHHLEHEAQGCDTLVLWLDCDREGENI 120
Query: 774 GFEIIDVCK 800
FE++ V +
Sbjct: 121 CFEVMQVVR 129
>UniRef50_Q5ANG9 Cluster: Likely DNA topoisomerase III; n=5;
Saccharomycetales|Rep: Likely DNA topoisomerase III -
Candida albicans (Yeast)
Length = 629
Score = 91.5 bits (217), Expect = 3e-17
Identities = 50/134 (37%), Positives = 72/134 (53%), Gaps = 2/134 (1%)
Frame = +3
Query: 405 MKYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQD--CEMVMTSVSG 578
M+ L VAEK +K +A L G R K+ K Y F +D C++ MTSV+G
Sbjct: 1 MRILCVAEKPSISKEVANILGGGRKKVRNSREKFIKNYDFTFTFNSEDGPCQVTMTSVAG 60
Query: 579 HLLALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDR 758
H+ L+F + +W C P LF+A + + + I + E R+ L+IWTDCDR
Sbjct: 61 HITGLDFGSAF-SWGNCVPGRLFEADIKTIITK--KSIYENIAEEARNADKLMIWTDCDR 117
Query: 759 EGENIGFEIIDVCK 800
EGE IGFEI++ +
Sbjct: 118 EGEYIGFEIMNAAR 131
>UniRef50_Q0U0G1 Cluster: DNA topoisomerase; n=14;
Pezizomycotina|Rep: DNA topoisomerase - Phaeosphaeria
nodorum (Septoria nodorum)
Length = 777
Score = 91.5 bits (217), Expect = 3e-17
Identities = 54/164 (32%), Positives = 82/164 (50%), Gaps = 7/164 (4%)
Frame = +3
Query: 408 KYLNVAEKNDAAKNIALHL---SKGTSTRREGLSKY----NKIYQFKANVMGQDCEMVMT 566
+ L VAEK AK +A HL ++ + +E + N + F+ GQ + T
Sbjct: 3 RVLCVAEKPSIAKAVANHLGGQARAADSEQEAVRGIQWVKNYKFDFRFQQWGQS-NVTFT 61
Query: 567 SVSGHLLALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWT 746
V+GH++A +F +R W +C P LFDAP+ E+ + + +E + R L IWT
Sbjct: 62 CVAGHIVAQDFPDRFRKWHSCQPADLFDAPIQSSIAEDKKIVASNIEAQARYASILFIWT 121
Query: 747 DCDREGENIGFEIIDVCKXCQDKFENI*SKXSEITLVSVNRALQ 878
DCDREGE+IG EI D+ + ++ S I V +A Q
Sbjct: 122 DCDREGEHIGTEIRDIALKVNPNMQVYRARFSNIERAHVIQASQ 165
>UniRef50_Q9SKZ9 Cluster: Putative DNA topoisomerase III beta; n=1;
Arabidopsis thaliana|Rep: Putative DNA topoisomerase III
beta - Arabidopsis thaliana (Mouse-ear cress)
Length = 836
Score = 90.6 bits (215), Expect = 5e-17
Identities = 57/172 (33%), Positives = 90/172 (52%), Gaps = 11/172 (6%)
Frame = +3
Query: 309 NMLQCL--EKLNSRLNRTLCFLVNKQIFVNKYSTMKYLNVAEKNDAAKNIALHLSKGTST 482
N+L+ L +L S +N+ + + F++ S+ + VAEK A +IA LS G +
Sbjct: 3 NLLRVLMVSELGSPINQFRFYFSHHYFFISYNSS--FHQVAEKPSIALSIASVLSHGQMS 60
Query: 483 RREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHLLALEFSGTYRTWQTCSPLSLFDAPVF 662
R G ++ +++F G +TSV GH+ +++F Y+ W T P LFDAP+
Sbjct: 61 TRRGSTE---VHEFDGMFRGFKAHYRVTSVIGHVFSVDFPEKYQNWATIDPQDLFDAPII 117
Query: 663 KYCPENYQKIKMT---------LEREVRSCQGLIIWTDCDREGENIGFEIID 791
K E+ K+ + L E R C +++W DCDREGENI FE+I+
Sbjct: 118 K--KESNPKVNIFKSQAHICRHLSNEARGCSYMVLWLDCDREGENICFEVIE 167
>UniRef50_A3FQH8 Cluster: DNA topoisomerase III, putative; n=3;
Cryptosporidium|Rep: DNA topoisomerase III, putative -
Cryptosporidium parvum Iowa II
Length = 814
Score = 90.6 bits (215), Expect = 5e-17
Identities = 55/159 (34%), Positives = 75/159 (47%), Gaps = 4/159 (2%)
Frame = +3
Query: 414 LNVAEKNDAAKNIALHLSKG--TSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHLL 587
L VAEKN AK IA L + + + SK N F G +C M++TSV GHL
Sbjct: 48 LCVAEKNSVAKEIANILCPEFQSPNKLKSKSKTNVALYFPYEFCGDECNMIVTSVRGHLK 107
Query: 588 ALEFSGTYRTWQTCSPLSLFD--APVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDRE 761
L F+ Y W + +P+ L D PV + I L + LI+W DCDRE
Sbjct: 108 QLGFASKYSDWGSVNPVVLLDLSTPVISSILPDCMGIADNLTYFSKISSYLILWLDCDRE 167
Query: 762 GENIGFEIIDVCKXCQDKFENI*SKXSEITLVSVNRALQ 878
GENI FE++ +C + S IT +N A++
Sbjct: 168 GENIAFEVLSICLNSNKNLITFRAHFSAITKFEINNAMK 206
>UniRef50_A2DNF5 Cluster: DNA topoisomerase; n=2; Trichomonas
vaginalis G3|Rep: DNA topoisomerase - Trichomonas
vaginalis G3
Length = 662
Score = 89.8 bits (213), Expect = 8e-17
Identities = 46/131 (35%), Positives = 70/131 (53%)
Frame = +3
Query: 408 KYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHLL 587
K L VAEK A+ A LS G ++G SK+N + F+ + G+D ++V TSV+GH+L
Sbjct: 4 KILCVAEKPSVAREAAKILSNGHMETKKGKSKFNNNFVFQRDFQGEDVKVVFTSVAGHVL 63
Query: 588 ALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDREGE 767
F + WQT LFD + N +K+ L+ + + + +W D DREGE
Sbjct: 64 NYCFPPECKNWQTFGNTKLFDCQLNTCITANMEKVVGNLQTQAKKAFLVFLWLDNDREGE 123
Query: 768 NIGFEIIDVCK 800
I E+ ++CK
Sbjct: 124 GISEEVEEICK 134
>UniRef50_Q9U286 Cluster: DNA topoisomerase; n=2; Bilateria|Rep: DNA
topoisomerase - Caenorhabditis elegans
Length = 855
Score = 88.2 bits (209), Expect = 2e-16
Identities = 44/134 (32%), Positives = 69/134 (51%)
Frame = +3
Query: 414 LNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHLLAL 593
L VAEK A +IA LS G + +R+G + + ++ G+ +TS GH+++L
Sbjct: 6 LMVAEKPLLADSIANLLSNGQAKKRKGWNGVCSVSEYDGQFNGRAARFKVTSTCGHVMSL 65
Query: 594 EFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDREGENI 773
+F + W+ P L+ AP + K+ L E ++ L++W DCD+EGENI
Sbjct: 66 DFPPKFNNWERVDPAELYSAPTQRIEANPKMKMNEFLASEAKNADFLVLWLDCDKEGENI 125
Query: 774 GFEIIDVCKXCQDK 815
FE+ID K K
Sbjct: 126 CFEVIDAVKCAMFK 139
>UniRef50_A5BC76 Cluster: Putative uncharacterized protein; n=2;
Vitis vinifera|Rep: Putative uncharacterized protein -
Vitis vinifera (Grape)
Length = 1226
Score = 87.8 bits (208), Expect = 3e-16
Identities = 53/170 (31%), Positives = 82/170 (48%), Gaps = 1/170 (0%)
Frame = +3
Query: 285 ENNITFIKNMLQCLEKLNSRLNRTLCFLVNKQIFVNKYSTMKYLNVAEKNDAAKNIALHL 464
EN+ +K ++ L+ + + N F+ K L VAEK +A +IA L
Sbjct: 88 ENHAPAMKLTVKTLKGSTTTAKASSSTTENTHGFMAPPKPHKILMVAEKPSSALSIASTL 147
Query: 465 SKG-TSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHLLALEFSGTYRTWQTCSPLS 641
S G STRR + ++++F G + + TSV +++F Y+ W PL
Sbjct: 148 SDGHMSTRRSSI----EVHEFNGTFRGSNAQYKATSVIDMFFSVDFPAKYQDWTIVDPLD 203
Query: 642 LFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDREGENIGFEIID 791
F AP+ K I L +E R C L++W DCDREG+NI FE+++
Sbjct: 204 FFQAPIHKAEXNPKAHICRRLSQEARVCGHLVLWLDCDREGDNICFEVVE 253
>UniRef50_UPI0001509E74 Cluster: DNA topoisomerase family protein;
n=1; Tetrahymena thermophila SB210|Rep: DNA
topoisomerase family protein - Tetrahymena thermophila
SB210
Length = 858
Score = 87.0 bits (206), Expect = 6e-16
Identities = 55/166 (33%), Positives = 83/166 (50%), Gaps = 5/166 (3%)
Frame = +3
Query: 396 YSTMKYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVS 575
+ ++ L VAEK A+ IA LS+ T+R ++++ F + C + +TSV
Sbjct: 3 FPPVQVLMVAEKPSIARTIAQALSQQVHTQRRN---NHEVHFFPSYFFQMPCLIKVTSVV 59
Query: 576 GHLLALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCD 755
GH+ + +FS Y P+ LFDAP K I L+ E + C L++W D D
Sbjct: 60 GHIFSTDFSPEYNG-NDVDPIKLFDAPTIKKFSSPSSTIIQHLKNEAQGCNFLVLWLDND 118
Query: 756 REGENIGFEIIDVCKXCQDKFEN-----I*SKXSEITLVSVNRALQ 878
REGENI FE+I VC + F+ +K S IT V + +A +
Sbjct: 119 REGENICFEVIQVCDSFLNVFDRNSKYIFRAKFSSITQVDIIKAYE 164
>UniRef50_Q016P5 Cluster: DNA topoisomerase; n=2; Eukaryota|Rep: DNA
topoisomerase - Ostreococcus tauri
Length = 2117
Score = 83.8 bits (198), Expect = 5e-15
Identities = 56/163 (34%), Positives = 86/163 (52%), Gaps = 8/163 (4%)
Frame = +3
Query: 414 LNVAEKNDAAKNIALHLSKGTS-TRREGLSKYNKIYQFKANVMG--QDCEMVMTSVSGHL 584
L VAEK A IA L+ G + T R+G + +++F +G + +TSV GH+
Sbjct: 1590 LCVAEKPSLAALIAGFLAPGGAFTTRKGFA--GDVHEFTGRGLGTMRSRAWRVTSVKGHV 1647
Query: 585 LALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDREG 764
+++F +++W++C P LF AP K K+ LE E + LI+W DCDREG
Sbjct: 1648 ASVDFPERFQSWESCDPGELFAAPTVKRADG---KMVRHLESEAKGAMTLILWLDCDREG 1704
Query: 765 ENIGFEIIDVCKXCQ-----DKFENI*SKXSEITLVSVNRALQ 878
ENI FE+I+ C + E + +K S +T SV A++
Sbjct: 1705 ENICFEVIEACAPSMRTSGGGEREILRAKFSAVTKDSVENAMK 1747
>UniRef50_A2Z2S2 Cluster: DNA topoisomerase; n=3; Oryza sativa|Rep:
DNA topoisomerase - Oryza sativa subsp. indica (Rice)
Length = 893
Score = 82.2 bits (194), Expect = 2e-14
Identities = 36/93 (38%), Positives = 54/93 (58%)
Frame = +3
Query: 513 IYQFKANVMGQDCEMVMTSVSGHLLALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKI 692
+++F G +TSV GH+L+++F Y+ W+ P+ LF APV + I
Sbjct: 67 VHEFDGMFQGSHAFFKVTSVIGHVLSVDFPPAYQNWEGTDPMDLFVAPVLRSECNPKAHI 126
Query: 693 KMTLEREVRSCQGLIIWTDCDREGENIGFEIID 791
+ L +E R C L++W DCDREGENI +E+ID
Sbjct: 127 RRHLAQEARGCTYLVLWLDCDREGENICYEVID 159
>UniRef50_Q6C0R0 Cluster: DNA topoisomerase; n=1; Yarrowia
lipolytica|Rep: DNA topoisomerase - Yarrowia lipolytica
(Candida lipolytica)
Length = 620
Score = 79.0 bits (186), Expect = 1e-13
Identities = 49/129 (37%), Positives = 66/129 (51%), Gaps = 1/129 (0%)
Frame = +3
Query: 405 MKYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQD-CEMVMTSVSGH 581
MK L VAEK AK + L G +TR +K+ K Y F+ + G C+ MTSV GH
Sbjct: 1 MKVLCVAEKPSVAKAVCNILGGGFTTRHTA-NKFVKNYDFQYDFPGWGRCDCTMTSVLGH 59
Query: 582 LLALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDRE 761
L EF + LF P+ + +K + +E R + L+IWTDCDRE
Sbjct: 60 LTDSEFVSEDARKFGYNAARLFTEPITTQVKADMRKCADNIVKEARHARKLLIWTDCDRE 119
Query: 762 GENIGFEII 788
GE IG+EI+
Sbjct: 120 GEYIGWEIV 128
>UniRef50_A0DGW1 Cluster: DNA topoisomerase; n=1; Paramecium
tetraurelia|Rep: DNA topoisomerase - Paramecium
tetraurelia
Length = 949
Score = 78.2 bits (184), Expect = 3e-13
Identities = 46/132 (34%), Positives = 65/132 (49%)
Frame = +3
Query: 399 STMKYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSG 578
S +K L VAEKN A+ +A + ++ G + Y F GQ +T+ +G
Sbjct: 28 SNLKILMVAEKNSIAEAVAYAIGNKVRAKK-GRQAF---YYFSGMFKGQQANFTVTATNG 83
Query: 579 HLLALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDR 758
HL + +F Y W +C P+ LF A K P N I + L + LI+W D DR
Sbjct: 84 HLFSRDFPKEYENWNSCDPIDLFQAKTIKK-PANKAGIGL-LRKCSSGIDYLILWLDNDR 141
Query: 759 EGENIGFEIIDV 794
EGENI FE+ +V
Sbjct: 142 EGENICFEVDEV 153
>UniRef50_A4RZ61 Cluster: DNA topoisomerase; n=2; cellular
organisms|Rep: DNA topoisomerase - Ostreococcus
lucimarinus CCE9901
Length = 863
Score = 77.8 bits (183), Expect = 3e-13
Identities = 37/94 (39%), Positives = 54/94 (57%)
Frame = +3
Query: 516 YQFKANVMGQDCEMVMTSVSGHLLALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIK 695
+ F + E +TS +GH+ ++EFS Y+ W+ C P LF A V K ++
Sbjct: 54 WAFASGTRDGRAEWRVTSTTGHVASVEFSARYQAWEGCEPGELFAADVVKRADG---RMV 110
Query: 696 MTLEREVRSCQGLIIWTDCDREGENIGFEIIDVC 797
LERE R C L+++ DCDREGENI FE+++ C
Sbjct: 111 GHLEREARGCDYLVLFLDCDREGENICFEVMEAC 144
>UniRef50_Q4UB92 Cluster: DNA topoisomerase iii, putative; n=2;
Theileria|Rep: DNA topoisomerase iii, putative -
Theileria annulata
Length = 607
Score = 69.3 bits (162), Expect = 1e-10
Identities = 36/87 (41%), Positives = 47/87 (54%)
Frame = +3
Query: 405 MKYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHL 584
+ LNVAEK AKNI LS G +TR SK N +Y F G C+M TSV GHL
Sbjct: 2 LNVLNVAEKPSVAKNITEILSCGNATRELTHSKTNPVYSFPHWFEGNMCKMYFTSVKGHL 61
Query: 585 LALEFSGTYRTWQTCSPLSLFDAPVFK 665
+ L+F YR+W + + LF ++
Sbjct: 62 MNLDFDQPYRSWHRTAIIDLFTGKFYQ 88
>UniRef50_A7AST5 Cluster: DNA topoisomerase, putative; n=1; Babesia
bovis|Rep: DNA topoisomerase, putative - Babesia bovis
Length = 878
Score = 68.5 bits (160), Expect = 2e-10
Identities = 45/148 (30%), Positives = 72/148 (48%), Gaps = 15/148 (10%)
Frame = +3
Query: 399 STMKYLNVAEKNDAAKNIALHL--SKGTSTRREGLSK-----------YNKI--YQFKAN 533
S K L VAEK A+ +A HL + T +R+G+S+ N ++ +
Sbjct: 2 SIPKVLVVAEKPKIAETLAAHLCTDQRTLLKRKGVSEDIMCDLGIHIISNTCITWECRGK 61
Query: 534 VMGQDCEMVMTSVSGHLLALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLERE 713
+ + +TS +GH+ ++ F+ Y W + +P+ LF+ + KI L E
Sbjct: 62 FLSTTVDFKVTSTAGHIYSVAFAPRYNCWNSTNPVELFNGEIILEEASPDSKIPRHLASE 121
Query: 714 VRSCQGLIIWTDCDREGENIGFEIIDVC 797
+ C L++ D DREGENI FE+I VC
Sbjct: 122 AKGCSYLLLCLDNDREGENIAFEVIRVC 149
>UniRef50_Q7QZC9 Cluster: DNA topoisomerase; n=1; Giardia lamblia
ATCC 50803|Rep: DNA topoisomerase - Giardia lamblia ATCC
50803
Length = 896
Score = 64.5 bits (150), Expect = 3e-09
Identities = 43/129 (33%), Positives = 64/129 (49%), Gaps = 2/129 (1%)
Frame = +3
Query: 414 LNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQF--KANVMGQDCEMVMTSVSGHLL 587
L V EKN A ++ LSKG+ ++++ + +N+ Y+F G + V+ GH+L
Sbjct: 6 LCVTEKNSVAAEVSNVLSKGSYSKKQLVQYFNE-YKFTHSEEEHGPAQQYVVVHAQGHML 64
Query: 588 ALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDREGE 767
LE Y W CSP LF V + N K L L++ D DREGE
Sbjct: 65 ELEPDEGYE-WGKCSPSDLFTCGV--HFKANAVFKKHVLRPNAAETNVLVLMLDADREGE 121
Query: 768 NIGFEIIDV 794
NIG++II++
Sbjct: 122 NIGYDIIEI 130
>UniRef50_Q2H6C2 Cluster: Putative uncharacterized protein; n=2;
Sordariales|Rep: Putative uncharacterized protein -
Chaetomium globosum (Soil fungus)
Length = 680
Score = 63.3 bits (147), Expect = 8e-09
Identities = 37/106 (34%), Positives = 51/106 (48%), Gaps = 2/106 (1%)
Frame = +3
Query: 408 KYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQ--DCEMVMTSVSGH 581
+ L VAEK +K +A HLS G + Y K Y F + C + MT+V GH
Sbjct: 3 RILCVAEKPSISKAVAGHLSGGQYQTNNTRNTYIKNYTFDYDFGPPWGHCSVTMTAVKGH 62
Query: 582 LLALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVR 719
L +EF Y+ W+ P LFDAPV P + + I +E + R
Sbjct: 63 LTTVEFPSDYKQWEYPPPDRLFDAPVLTVIPPDNKSIAKNIEDQAR 108
>UniRef50_A7D4M8 Cluster: DNA topoisomerase; n=1; Halorubrum
lacusprofundi ATCC 49239|Rep: DNA topoisomerase -
Halorubrum lacusprofundi ATCC 49239
Length = 912
Score = 61.3 bits (142), Expect = 3e-08
Identities = 48/153 (31%), Positives = 75/153 (49%)
Frame = +3
Query: 414 LNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHLLAL 593
L + EK++AA+ IA LS G S E + N +Y++ G+ C +SGH++ +
Sbjct: 55 LIITEKDNAARRIADILS-GESATAERENDVN-VYKWG----GKRC----IGLSGHVVGV 104
Query: 594 EFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDREGENI 773
+F Y W+ P+ L DAP+ K + I L + R+ ++I TD DREGE I
Sbjct: 105 DFPAEYNDWRDVEPVELIDAPITK--EPTQEGIVAALRKLARNASRVVIATDYDREGELI 162
Query: 774 GFEIIDVCKXCQDKFENI*SKXSEITLVSVNRA 872
G E ++ + + + S IT VN A
Sbjct: 163 GKEAYELVREVNEDAPIDRVRFSSITDNEVNEA 195
>UniRef50_Q1AUL7 Cluster: DNA topoisomerase I; n=1; Rubrobacter
xylanophilus DSM 9941|Rep: DNA topoisomerase I -
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Length = 702
Score = 58.8 bits (136), Expect = 2e-07
Identities = 40/127 (31%), Positives = 62/127 (48%)
Frame = +3
Query: 414 LNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHLLAL 593
L ++EK +AA+ IA L++G +EG K+ + G++C V + GH+L
Sbjct: 3 LIISEKANAARKIAQFLAEGPV--KEG--KHRSVPYHTFTWRGEEC--VSVGLKGHVLNP 56
Query: 594 EFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDREGENI 773
E+ Y WQ P L DA + K E + + + + +II TD DREGE I
Sbjct: 57 EYPEEYSNWQKVDPRELIDARILKSVSE--KGVAAAVRSLAKKADRVIIATDFDREGELI 114
Query: 774 GFEIIDV 794
G E + +
Sbjct: 115 GVEALSL 121
>UniRef50_Q64CK3 Cluster: DNA topoisomerase; n=1; uncultured
archaeon GZfos21B5|Rep: DNA topoisomerase - uncultured
archaeon GZfos21B5
Length = 681
Score = 55.2 bits (127), Expect = 2e-06
Identities = 44/149 (29%), Positives = 67/149 (44%)
Frame = +3
Query: 405 MKYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHL 584
M Y+ + EK AK IA LS G + ++ KI A+ E V+ +SGH+
Sbjct: 1 MHYI-ITEKGTTAKKIAAILSNGKAKKK-------KIGGIDAHEFD---EKVVIGLSGHV 49
Query: 585 LALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDREG 764
L+F +Y W P L DA + + + I TL + + + + TD DREG
Sbjct: 50 FRLDFPDSYNNWSKVDPYKLIDAKIVTVALK--KDIVKTLGQIAKKADYITVATDYDREG 107
Query: 765 ENIGFEIIDVCKXCQDKFENI*SKXSEIT 851
E IG E ++ K + + + S IT
Sbjct: 108 ELIGVEALNSIKKINPELKVDRMRYSAIT 136
>UniRef50_A1RYK6 Cluster: DNA topoisomerase; n=1; Thermofilum
pendens Hrk 5|Rep: DNA topoisomerase - Thermofilum
pendens (strain Hrk 5)
Length = 631
Score = 54.4 bits (125), Expect = 4e-06
Identities = 41/138 (29%), Positives = 62/138 (44%)
Frame = +3
Query: 408 KYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHLL 587
K + VAEKN A+ IA L G+S RR + + Y+F + + + + VSGH+L
Sbjct: 4 KAVIVAEKNSVARAIASFLG-GSSVRRFRVERV-PAYEF----LWEGGKHLSIGVSGHIL 57
Query: 588 ALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDREGE 767
+F Y W++ P LF E L+ R +I+ D D EGE
Sbjct: 58 DFDFPEEYNKWESVDPRVLFFTNPVLVTREGAYIYVRALKTLARQTSTVILALDADVEGE 117
Query: 768 NIGFEIIDVCKXCQDKFE 821
I FE++ + K + E
Sbjct: 118 AIAFEVMRIMKSVNPELE 135
>UniRef50_UPI0000F1E09D Cluster: PREDICTED: similar to MGC53016
protein, partial; n=1; Danio rerio|Rep: PREDICTED:
similar to MGC53016 protein, partial - Danio rerio
Length = 174
Score = 52.8 bits (121), Expect = 1e-05
Identities = 24/68 (35%), Positives = 38/68 (55%), Gaps = 1/68 (1%)
Frame = +3
Query: 465 SKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHLLALEFSGTYRTWQTCSPLSL 644
S G+ + R+GL+ ++++ + GQ+ MTSV GH+++L+F G Y W P L
Sbjct: 27 SSGSCSTRKGLNGACSVHEYMGSFTGQNVRFKMTSVCGHVMSLDFIGKYNNWDKVDPAEL 86
Query: 645 FD-APVFK 665
F AP K
Sbjct: 87 FSKAPTEK 94
>UniRef50_Q8TPW5 Cluster: DNA topoisomerase; n=3;
Methanosarcina|Rep: DNA topoisomerase - Methanosarcina
acetivorans
Length = 843
Score = 50.8 bits (116), Expect = 4e-05
Identities = 38/128 (29%), Positives = 59/128 (46%), Gaps = 2/128 (1%)
Frame = +3
Query: 405 MKYLNVAEKNDAAKNIALHLSKGTSTRR--EGLSKYNKIYQFKANVMGQDCEMVMTSVSG 578
M + AEKN AA IA L G + EGL Y +++K E ++ +SG
Sbjct: 1 MTVVAFAEKNKAAAQIASILGDGEVDKISVEGLPAYE--FKWKGE------EWLVMGLSG 52
Query: 579 HLLALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDR 758
H++ +F Y W +P +L K+ + +++ + +I+ D DR
Sbjct: 53 HIMNYDFPEQYNKWSEVNPGTLLGVDPEKFVTR--AEYATAIKKLAKRADKIILACDYDR 110
Query: 759 EGENIGFE 782
EGENIGFE
Sbjct: 111 EGENIGFE 118
>UniRef50_Q12Y06 Cluster: DNA topoisomerase; n=1; Methanococcoides
burtonii DSM 6242|Rep: DNA topoisomerase -
Methanococcoides burtonii (strain DSM 6242)
Length = 780
Score = 50.8 bits (116), Expect = 4e-05
Identities = 36/131 (27%), Positives = 64/131 (48%), Gaps = 2/131 (1%)
Frame = +3
Query: 426 EKNDAAKNIALHLSKGTSTRR--EGLSKYNKIYQFKANVMGQDCEMVMTSVSGHLLALEF 599
EKN AA I+ LS G++ R +G+S +Y+F+ + G +++ ++GH++ ++
Sbjct: 8 EKNKAAAQISTILSGGSAKRSIVDGVS----VYEFQRD--GSLWKIM--GLAGHIMGYDY 59
Query: 600 SGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDREGENIGF 779
+ W+ P +L D K N + + + L++ D DREGENIGF
Sbjct: 60 PEEFHNWRDVDPAALLDTDPVKQI--NKASFGSAILKISKGADLLVLACDFDREGENIGF 117
Query: 780 EIIDVCKXCQD 812
E + + D
Sbjct: 118 EAKSIAEKVSD 128
>UniRef50_Q0W2I3 Cluster: DNA topoisomerase I; n=1; uncultured
methanogenic archaeon RC-I|Rep: DNA topoisomerase I -
Uncultured methanogenic archaeon RC-I
Length = 767
Score = 50.4 bits (115), Expect = 6e-05
Identities = 41/131 (31%), Positives = 59/131 (45%), Gaps = 1/131 (0%)
Frame = +3
Query: 411 YLNVAEKNDAAKNIALHLSKG-TSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHLL 587
+L + EK+DAA IA L K T R G+ Y KA + ++ ++GH+L
Sbjct: 2 HLIITEKHDAASKIAAILFKDRTPERINGVPAYRS----KA------ADALVIGLAGHIL 51
Query: 588 ALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDREGE 767
L+F Y+ W P L A V Y + + + L + I TD DREGE
Sbjct: 52 ELDFPEAYQKWSAFPPRELIRAQVVTY--PSKKDLVGALATLATKVTRVTIATDYDREGE 109
Query: 768 NIGFEIIDVCK 800
IG E ++ K
Sbjct: 110 MIGVEAYNIIK 120
>UniRef50_A5BX18 Cluster: Putative uncharacterized protein; n=1;
Vitis vinifera|Rep: Putative uncharacterized protein -
Vitis vinifera (Grape)
Length = 632
Score = 47.6 bits (108), Expect = 4e-04
Identities = 18/34 (52%), Positives = 24/34 (70%)
Frame = +3
Query: 690 IKMTLEREVRSCQGLIIWTDCDREGENIGFEIID 791
I M L E R C L++W DCDREG+NI FE+++
Sbjct: 470 IGMRLSXEARDCGHLVLWXDCDREGDNICFEVVE 503
>UniRef50_A7I6L6 Cluster: DNA topoisomerase; n=1; Candidatus
Methanoregula boonei 6A8|Rep: DNA topoisomerase -
Methanoregula boonei (strain 6A8)
Length = 942
Score = 46.8 bits (106), Expect = 7e-04
Identities = 44/159 (27%), Positives = 73/159 (45%), Gaps = 5/159 (3%)
Frame = +3
Query: 411 YLNVAEKNDAAKNIALHLSKGTST---RREGLSKYNKIYQFKANVMGQDCEMVMTSVSGH 581
+L VAEKN +A IA L+ GT + G+S Y+ G + + + GH
Sbjct: 2 HLIVAEKNISAHRIAQILAGGTRVIEKKDAGVSTYS---------FG---DTITVGLRGH 49
Query: 582 LLALEFSGTYRTWQT--CSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCD 755
++ ++F Y W++ +P SL DA K E ++I +++ R + I TD D
Sbjct: 50 VVEVDFEPGYENWRSEKYTPRSLIDAKTIKVPTE--KRIVSLVQKLARHADRVTIATDFD 107
Query: 756 REGENIGFEIIDVCKXCQDKFENI*SKXSEITLVSVNRA 872
EGE IG E ++ + + ++ S IT + A
Sbjct: 108 TEGELIGKEAYELVRAVNKNVKIDRARFSAITAQEIGSA 146
>UniRef50_Q8SS31 Cluster: DNA TOPOISOMERASE III; n=1;
Encephalitozoon cuniculi|Rep: DNA TOPOISOMERASE III -
Encephalitozoon cuniculi
Length = 621
Score = 44.4 bits (100), Expect = 0.004
Identities = 24/49 (48%), Positives = 32/49 (65%)
Frame = +3
Query: 732 LIIWTDCDREGENIGFEIIDVCKXCQDKFENI*SKXSEITLVSVNRALQ 878
+IIWTDCDREGENIG +I D+ + K + ++ S ITL V AL+
Sbjct: 2 VIIWTDCDREGENIGRQIRDIVLKVK-KIDVRRARFSGITLRDVESALR 49
>UniRef50_Q33E26 Cluster: DNA topoisomerase; n=1; Enterococcus
faecium|Rep: DNA topoisomerase - Enterococcus faecium
(Streptococcus faecium)
Length = 787
Score = 43.6 bits (98), Expect = 0.007
Identities = 35/109 (32%), Positives = 52/109 (47%), Gaps = 7/109 (6%)
Frame = +3
Query: 495 LSKYNKIYQFKANVMGQDCEMVMTSVSGHLLALEFSGTYRTWQTCSPLSLFDAPVF-KYC 671
LSK + Y+FK+ + G + ++T GHL+ L Y L + P K+
Sbjct: 25 LSKKSGKYEFKSEIFG---DTIVTWGIGHLVGLSLPEKYEWLPNKDKWHLDNLPFLPKFN 81
Query: 672 PENYQKIKMTLERE--VRSC----QGLIIWTDCDREGENIGFEIIDVCK 800
Y+ K ++ V+SC +II TD DREGENI + I +CK
Sbjct: 82 ELKYEVSKGKNQQFSIVKSCLENADEIIIATDPDREGENIAYNIFKLCK 130
>UniRef50_A2SSK2 Cluster: DNA topoisomerase; n=3;
Methanomicrobiales|Rep: DNA topoisomerase -
Methanocorpusculum labreanum (strain ATCC 43576 / DSM
4855 / Z)
Length = 935
Score = 43.6 bits (98), Expect = 0.007
Identities = 41/160 (25%), Positives = 76/160 (47%), Gaps = 4/160 (2%)
Frame = +3
Query: 411 YLNVAEKNDAAKNIALHLSKGTSTR--REGLSKYNKIYQFKANVMGQDCEMVMTSVSGHL 584
+L +AEKN A+ IA L+ + R+G + + Y F + V+ + GH+
Sbjct: 2 HLIIAEKNIVAERIAAFLAGKAKVQVTRDGAAAH---YVFD--------DTVVMGLRGHV 50
Query: 585 LALEFSGTYRTWQTCS--PLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDR 758
+ ++F Y W++ P SL +A + K E +KI +++ + + I TD D
Sbjct: 51 VEVDFVEGYNNWRSVEHPPRSLINADIVKKPTE--KKIVGLMQKFGKKATRVTIATDYDT 108
Query: 759 EGENIGFEIIDVCKXCQDKFENI*SKXSEITLVSVNRALQ 878
EGE IG E ++ + K ++ S IT + ++++
Sbjct: 109 EGELIGKEAFELIRAANPKVPIDRARFSAITKDEIVKSIK 148
>UniRef50_UPI0001555C8D Cluster: PREDICTED: similar to topoisomerase
(DNA) III beta, partial; n=1; Ornithorhynchus
anatinus|Rep: PREDICTED: similar to topoisomerase (DNA)
III beta, partial - Ornithorhynchus anatinus
Length = 249
Score = 40.7 bits (91), Expect = 0.048
Identities = 19/56 (33%), Positives = 32/56 (57%), Gaps = 2/56 (3%)
Frame = +3
Query: 474 TSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHLLALEFSG--TYRTWQTCSP 635
++T R+GL+ ++++ + GQ MTSV GH++AL+F G WQ+ P
Sbjct: 71 SATSRKGLNGACSVHEYNGSFAGQPVRFKMTSVCGHVMALDFIGFTEIMPWQSVPP 126
>UniRef50_Q7QZE9 Cluster: GLP_43_17393_20314; n=1; Giardia lamblia
ATCC 50803|Rep: GLP_43_17393_20314 - Giardia lamblia
ATCC 50803
Length = 973
Score = 40.3 bits (90), Expect = 0.063
Identities = 37/133 (27%), Positives = 62/133 (46%), Gaps = 4/133 (3%)
Frame = +3
Query: 414 LNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHLLAL 593
L +AEK A+ I+ + +G + + +S Y F + G + TSV+GH+ +
Sbjct: 3 LLIAEKPSIAEMISRNYGEGAK-KLDNVSF--PTYTFVQSFEGSKETFMCTSVAGHVFEI 59
Query: 594 EFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQG----LIIWTDCDRE 761
+F + LF+ Y ++ T+ + ++S G LI+ D DRE
Sbjct: 60 DFDAELNG-SSVPQERLFERGHVHY---SFTDSGSTVAKHLKSIGGKAMQLILCLDNDRE 115
Query: 762 GENIGFEIIDVCK 800
GENI FE++ V K
Sbjct: 116 GENICFEVLKVLK 128
>UniRef50_A7NJW2 Cluster: DNA topoisomerase I; n=2;
Chloroflexaceae|Rep: DNA topoisomerase I - Roseiflexus
castenholzii DSM 13941
Length = 836
Score = 39.1 bits (87), Expect = 0.15
Identities = 20/55 (36%), Positives = 30/55 (54%)
Frame = +3
Query: 651 APVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDREGENIGFEIIDVCKXCQDK 815
APV++ P +KI L + +R + + TD DREGE I + I + K +DK
Sbjct: 51 APVYEISPGK-EKIIAALRKSIRQADAVYLATDPDREGEAIAWHITEAAKIPRDK 104
>UniRef50_Q48NI0 Cluster: DNA topoisomerase III; n=1; Pseudomonas
syringae pv. phaseolicola 1448A|Rep: DNA topoisomerase
III - Pseudomonas syringae pv. phaseolicola (strain
1448A / Race 6)
Length = 483
Score = 35.5 bits (78), Expect = 1.8
Identities = 18/49 (36%), Positives = 28/49 (57%)
Frame = +3
Query: 672 PENYQKIKMTLEREVRSCQGLIIWTDCDREGENIGFEIIDVCKXCQDKF 818
P+ + K+ +++ ++ L+I TD DREGE I E+ID C D F
Sbjct: 77 PKTSSQFKV-VKQLLKEATELVIATDADREGELIARELIDYCGYADDLF 124
>UniRef50_O87222 Cluster: DNA topoisomerase; n=21; Firmicutes|Rep:
DNA topoisomerase - Lactococcus lactis
Length = 725
Score = 35.5 bits (78), Expect = 1.8
Identities = 36/137 (26%), Positives = 65/137 (47%), Gaps = 5/137 (3%)
Frame = +3
Query: 405 MKYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCEMVMTSVSGHL 584
MK + +AEK A + A K T+++G ++ V+ E +T GHL
Sbjct: 1 MKTIVLAEKPSQASDYANAFQK--HTKKQGY------FEVSDPVLAN--ETFITYGFGHL 50
Query: 585 LAL----EFSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLERE-VRSCQGLIIWTD 749
+ L ++ Y+ W + L +F +K+ +K + ++ + ++ +II TD
Sbjct: 51 VELASPEQYDTKYKKWDLKN-LPIFPEK-YKFIVPKDKKGQFSIVSDLIKDADQIIIATD 108
Query: 750 CDREGENIGFEIIDVCK 800
DREGENI + I++ K
Sbjct: 109 SDREGENIAWSILNKAK 125
>UniRef50_Q98RZ5 Cluster: Putative uncharacterized protein orf419;
n=1; Guillardia theta|Rep: Putative uncharacterized
protein orf419 - Guillardia theta (Cryptomonas phi)
Length = 419
Score = 35.5 bits (78), Expect = 1.8
Identities = 39/163 (23%), Positives = 67/163 (41%), Gaps = 1/163 (0%)
Frame = +3
Query: 198 TFPXIFRVIFSAAGIHIYRFNIKILSLCYENNITFIKNMLQCLEKLNSRLNRTLCFLVN- 374
T+ +F++ +RFN L+ CY N KN+ + K LN L L N
Sbjct: 192 TWKNLFKINLLTYSYVYFRFNN--LTFCYNFNSEIQKNIKVLILKSKWPLNSYLILLKNK 249
Query: 375 KQIFVNKYSTMKYLNVAEKNDAAKNIALHLSKGTSTRREGLSKYNKIYQFKANVMGQDCE 554
K+IF N+Y N N NI+ + K + + ++ +N +F N+
Sbjct: 250 KKIFKNQYYCSTSFNSGSNNIIYSNISSKV-KQKNFFNQSITVFND--EFFQNIRLNYNY 306
Query: 555 MVMTSVSGHLLALEFSGTYRTWQTCSPLSLFDAPVFKYCPENY 683
+ ++ L L++ + S +LF++ VF NY
Sbjct: 307 IEYKNLELLFLKLQYDFSSYRMSKISKYNLFNSCVFNNSYYNY 349
>UniRef50_Q4AA55 Cluster: DNA topoisomerase I; n=5; Mycoplasma
hyopneumoniae|Rep: DNA topoisomerase I - Mycoplasma
hyopneumoniae (strain J / ATCC 25934 / NCTC 10110)
Length = 636
Score = 35.1 bits (77), Expect = 2.4
Identities = 20/59 (33%), Positives = 35/59 (59%)
Frame = +3
Query: 702 LEREVRSCQGLIIWTDCDREGENIGFEIIDVCKXCQDKFENI*SKXSEITLVSVNRALQ 878
+++ + + +II TD DREGE IG +++ DK++ I K +EIT ++ AL+
Sbjct: 68 IKKLAKQAKTVIIATDADREGEAIGASLVEHL-AITDKYQRI--KYNEITKTAILEALE 123
>UniRef50_O13290 Cluster: Dynein heavy chain, cytosolic; n=1;
Schizosaccharomyces pombe|Rep: Dynein heavy chain,
cytosolic - Schizosaccharomyces pombe (Fission yeast)
Length = 4196
Score = 35.1 bits (77), Expect = 2.4
Identities = 26/81 (32%), Positives = 44/81 (54%), Gaps = 1/81 (1%)
Frame = +3
Query: 630 SPLSLFDAPVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDREGENIGF-EIIDVCKXC 806
S +S+ + VFK +N +K+++ER++RS Q ++ T C +G EI+ + K
Sbjct: 3629 SVISVQEPGVFKQ-KDNCFTLKLSIERQIRSLQEQLLKTLCSSNENIVGTDEIVVLLKNL 3687
Query: 807 QDKFENI*SKXSEITLVSVNR 869
++K E I SE S+NR
Sbjct: 3688 KEKHETIRLAYSESQ--SINR 3706
>UniRef50_A6DDI1 Cluster: DNA topoisomerase I; n=1; Caminibacter
mediatlanticus TB-2|Rep: DNA topoisomerase I -
Caminibacter mediatlanticus TB-2
Length = 725
Score = 34.7 bits (76), Expect = 3.1
Identities = 21/68 (30%), Positives = 33/68 (48%)
Frame = +3
Query: 675 ENYQKIKMTLEREVRSCQGLIIWTDCDREGENIGFEIIDVCKXCQDKFENI*SKXSEITL 854
+++Q + L+ + + + + I TD DREGE IGF I V I EIT
Sbjct: 59 KDHQSVAKELKEKAKKAETIYIATDEDREGEAIGFHIAHVIGKDPSSLPRI--VFHEITK 116
Query: 855 VSVNRALQ 878
++ AL+
Sbjct: 117 TAIKNALK 124
>UniRef50_P34185 Cluster: DNA topoisomerase 1; n=23;
Cyanobacteria|Rep: DNA topoisomerase 1 - Synechococcus
sp. (strain PCC 7942) (Anacystis nidulans R2)
Length = 883
Score = 34.7 bits (76), Expect = 3.1
Identities = 17/48 (35%), Positives = 31/48 (64%)
Frame = +3
Query: 651 APVFKYCPENYQKIKMTLEREVRSCQGLIIWTDCDREGENIGFEIIDV 794
AP++ P++ +KI TL+ ++ LI+ TD DREGE+I + ++ +
Sbjct: 64 APLY-IVPKDKKKIVKTLKDALKDADELILATDEDREGESISWHLLQL 110
>UniRef50_Q6MP96 Cluster: DNA topoisomerase I; n=4; Bacteria|Rep:
DNA topoisomerase I - Bdellovibrio bacteriovorus
Length = 909
Score = 34.3 bits (75), Expect = 4.1
Identities = 16/46 (34%), Positives = 28/46 (60%), Gaps = 1/46 (2%)
Frame = +3
Query: 666 YC-PENYQKIKMTLEREVRSCQGLIIWTDCDREGENIGFEIIDVCK 800
YC P++ K+ L+ ++ L + TD DREGE+I + +++V K
Sbjct: 76 YCVPKDKTKVVKNLKDKLEEASELYLATDEDREGESISWHLLEVLK 121
>UniRef50_Q98Q95 Cluster: DNA TOPOISOMERASE I; n=2; Mycoplasma|Rep:
DNA TOPOISOMERASE I - Mycoplasma pulmonis
Length = 625
Score = 33.9 bits (74), Expect = 5.5
Identities = 32/98 (32%), Positives = 46/98 (46%)
Frame = +3
Query: 507 NKIYQFKANVMGQDCEMVMTSVSGHLLALEFSGTYRTWQTCSPLSLFDAPVFKYCPENYQ 686
NKI + +G+D +V SV GH+ L SG Y P+ K PE +
Sbjct: 17 NKIKAI-SKYLGKDY-VVKASV-GHIAYLPASGAYGLGIDLENWQ----PLMKMDPEK-R 68
Query: 687 KIKMTLEREVRSCQGLIIWTDCDREGENIGFEIIDVCK 800
I L+ + + I TD DREGE+IG ++D+ K
Sbjct: 69 AICKELKEAADKSELVYIATDPDREGESIGQNLVDILK 106
>UniRef50_A6RLG6 Cluster: Putative uncharacterized protein; n=2;
Sclerotiniaceae|Rep: Putative uncharacterized protein -
Botryotinia fuckeliana B05.10
Length = 553
Score = 33.9 bits (74), Expect = 5.5
Identities = 14/34 (41%), Positives = 19/34 (55%)
Frame = -3
Query: 400 EYLFTNICLFTKKQSVLFNLLFSFSRHCNIFFIN 299
EY+F IC+F + L +L + FS C FF N
Sbjct: 8 EYVFIRICIFALQSIPLVSLAYCFSLACTTFFTN 41
>UniRef50_Q4FM27 Cluster: TrkH-like cation transport protein; n=2;
Candidatus Pelagibacter ubique|Rep: TrkH-like cation
transport protein - Pelagibacter ubique
Length = 469
Score = 33.5 bits (73), Expect = 7.2
Identities = 14/39 (35%), Positives = 25/39 (64%)
Frame = -3
Query: 436 SFFSATFKYFIVEYLFTNICLFTKKQSVLFNLLFSFSRH 320
+FF+ T+ Y++ YL N +FT S+L +LF +S++
Sbjct: 20 AFFNITYSYYLNLYLNLNTYIFTFIVSILLTILFYYSKN 58
>UniRef50_P74600 Cluster: Slr1568 protein; n=1; Synechocystis sp.
PCC 6803|Rep: Slr1568 protein - Synechocystis sp.
(strain PCC 6803)
Length = 136
Score = 33.5 bits (73), Expect = 7.2
Identities = 22/79 (27%), Positives = 36/79 (45%), Gaps = 6/79 (7%)
Frame = +3
Query: 552 EMVMTSVSGHLLALEFSG-TY--RTWQTCSPLSLFD---APVFKYCPENYQKIKMTLERE 713
E V + GH L LE G TY W C + + P PEN Q + + ++++
Sbjct: 43 EEVQEPIPGHRLILENEGQTYGVNIWDLCFQVCFANYQAQPFGDNLPENNQALAVEIDQD 102
Query: 714 VRSCQGLIIWTDCDREGEN 770
+ + QG + WT D + +
Sbjct: 103 LFNDQGEVDWTKLDHKARH 121
>UniRef50_A6C5M1 Cluster: DNA topoisomerase; n=1; Planctomyces maris
DSM 8797|Rep: DNA topoisomerase - Planctomyces maris DSM
8797
Length = 909
Score = 33.5 bits (73), Expect = 7.2
Identities = 15/43 (34%), Positives = 27/43 (62%)
Frame = +3
Query: 672 PENYQKIKMTLEREVRSCQGLIIWTDCDREGENIGFEIIDVCK 800
P+ +K L+ ++ + LI+ TD DREGE+IG+ + ++ K
Sbjct: 76 PKEKKKTVKELKDALKDAEELILATDEDREGESIGWHLAELLK 118
>UniRef50_A0CP28 Cluster: Chromosome undetermined scaffold_23, whole
genome shotgun sequence; n=1; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_23,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 556
Score = 33.5 bits (73), Expect = 7.2
Identities = 21/69 (30%), Positives = 40/69 (57%)
Frame = +3
Query: 246 IYRFNIKILSLCYENNITFIKNMLQCLEKLNSRLNRTLCFLVNKQIFVNKYSTMKYLNVA 425
I + NIK+L + Y N + IKN+ CL+ L++++N ++ + N Y+ +K LN+
Sbjct: 113 INQLNIKVLMISY-NKLKEIKNLPLCLKILDAKIN-----MIERVDLQNLYN-LKVLNLQ 165
Query: 426 EKNDAAKNI 452
+ N + N+
Sbjct: 166 KNNITSVNL 174
>UniRef50_O51768 Cluster: DNA topoisomerase 1; n=3; Borrelia
burgdorferi group|Rep: DNA topoisomerase 1 - Borrelia
burgdorferi (Lyme disease spirochete)
Length = 848
Score = 33.5 bits (73), Expect = 7.2
Identities = 16/43 (37%), Positives = 25/43 (58%)
Frame = +3
Query: 672 PENYQKIKMTLEREVRSCQGLIIWTDCDREGENIGFEIIDVCK 800
P N + I L++ V++ + + TD DREGE I F + +V K
Sbjct: 72 PSNKKPIVSKLKKLVKTINEIYLATDQDREGETIAFHLKEVLK 114
>UniRef50_Q5EP76 Cluster: TopB; n=1; Neisseria gonorrhoeae|Rep: TopB
- Neisseria gonorrhoeae
Length = 679
Score = 33.1 bits (72), Expect = 9.6
Identities = 23/89 (25%), Positives = 37/89 (41%), Gaps = 4/89 (4%)
Frame = +3
Query: 543 QDCEMVMTSVSGHLLALE----FSGTYRTWQTCSPLSLFDAPVFKYCPENYQKIKMTLER 710
Q+ + ++T GH+L + Y + S L + P K ++
Sbjct: 31 QNGDTIVTWAFGHILTQAAPDAYGEQYADFGNISALPILPEVWQMQVPPKVSKQFKVIKS 90
Query: 711 EVRSCQGLIIWTDCDREGENIGFEIIDVC 797
+ ++I TD DREGE I EI+D C
Sbjct: 91 LLAKADEVVIATDADREGEVIAREILDYC 119
>UniRef50_Q9LPA7 Cluster: T32E20.13; n=1; Arabidopsis thaliana|Rep:
T32E20.13 - Arabidopsis thaliana (Mouse-ear cress)
Length = 1335
Score = 33.1 bits (72), Expect = 9.6
Identities = 14/48 (29%), Positives = 25/48 (52%)
Frame = -3
Query: 499 DSPSRLVDVPLDRCNAIFLAASFFSATFKYFIVEYLFTNICLFTKKQS 356
D SR ++ + C IFL +F+ + F F + + F+N+ + QS
Sbjct: 1162 DGTSRARELTAEDCTTIFLQVTFYVSQFSVFELSFSFSNLSFYHTLQS 1209
>UniRef50_Q8I452 Cluster: Putative uncharacterized protein PFE0245c;
n=1; Plasmodium falciparum 3D7|Rep: Putative
uncharacterized protein PFE0245c - Plasmodium falciparum
(isolate 3D7)
Length = 2961
Score = 33.1 bits (72), Expect = 9.6
Identities = 18/61 (29%), Positives = 31/61 (50%)
Frame = +3
Query: 267 ILSLCYENNITFIKNMLQCLEKLNSRLNRTLCFLVNKQIFVNKYSTMKYLNVAEKNDAAK 446
++S+ ENN F+ + ++ + +CFL ++ + KY MK +N KND K
Sbjct: 911 LISISKENNYIFLYILYTIVKPILKECYYLICFLTSQNEVMKKY--MKKINDNNKNDNNK 968
Query: 447 N 449
N
Sbjct: 969 N 969
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 741,569,235
Number of Sequences: 1657284
Number of extensions: 14358234
Number of successful extensions: 35317
Number of sequences better than 10.0: 80
Number of HSP's better than 10.0 without gapping: 33709
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 35274
length of database: 575,637,011
effective HSP length: 100
effective length of database: 409,908,611
effective search space used: 78702453312
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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