Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fdpeP09_F_P09
(903 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]... 313 4e-84
UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 288 2e-76
UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalyti... 248 1e-64
UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 239 9e-62
UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3; Bacteria... 231 1e-59
UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella ve... 220 3e-56
UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulato... 219 1e-55
UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulato... 215 1e-54
UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 208 2e-52
UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 204 2e-51
UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 199 7e-50
UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate dehydrog... 191 2e-47
UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;... 191 2e-47
UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8; Bilateri... 189 1e-46
UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 184 4e-45
UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2; Bacteria... 181 3e-44
UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p... 179 8e-44
UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 166 8e-40
UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep: C... 165 1e-39
UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1... 158 2e-37
UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68; Bacteri... 157 5e-37
UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependen... 148 2e-34
UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3; Ricketts... 147 3e-34
UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6; T... 146 7e-34
UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10; ... 141 2e-32
UniRef50_Q4UKR1 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 141 3e-32
UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate dehydrog... 135 1e-30
UniRef50_Q2UP37 Cluster: Isocitrate/isopropylmalate dehydrogenas... 131 2e-29
UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8; E... 130 4e-29
UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6; E... 127 3e-28
UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]... 125 1e-27
UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenas... 119 9e-26
UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependen... 118 2e-25
UniRef50_Q5HNL1 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 113 6e-24
UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD] s... 113 8e-24
UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421, ... 112 1e-23
UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;... 110 4e-23
UniRef50_O29610 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 110 4e-23
UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate... 109 9e-23
UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for ... 107 4e-22
UniRef50_Q6L2P9 Cluster: Isocitrate dehydrogenase [NADP]; n=2; T... 106 9e-22
UniRef50_Q58991 Cluster: Threo-isocitrate dehydrogenase [NAD]; n... 105 1e-21
UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 104 3e-21
UniRef50_Q9RTT2 Cluster: Isocitrate dehydrogenase, putative; n=2... 104 4e-21
UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9; B... 101 3e-20
UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3; P... 100 1e-19
UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2; Alp... 100 1e-19
UniRef50_Q0W1Q6 Cluster: 2-isopropylmalate dehydrogenase; n=5; E... 100 1e-19
UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 99 2e-19
UniRef50_O67480 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 99 2e-19
UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5; T... 96 9e-19
UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5; C... 95 2e-18
UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase, mitochond... 95 3e-18
UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 94 5e-18
UniRef50_Q9CKK6 Cluster: Idp; n=2; Pasteurellaceae|Rep: Idp - Pa... 92 2e-17
UniRef50_Q8FPV5 Cluster: 3-isopropylmalate dehydrogenase; n=50; ... 90 6e-17
UniRef50_A1SM34 Cluster: 3-isopropylmalate dehydrogenase; n=1; N... 89 2e-16
UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;... 86 1e-15
UniRef50_Q8XSY8 Cluster: Probable 3-isopropylmalate dehydrogenas... 86 1e-15
UniRef50_A7T3D9 Cluster: Predicted protein; n=1; Nematostella ve... 85 2e-15
UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma... 85 2e-15
UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;... 85 3e-15
UniRef50_A5URE6 Cluster: Isocitrate dehydrogenase, NADP-dependen... 82 2e-14
UniRef50_Q8U299 Cluster: 3-isopropylmalate dehydrogenase 2; n=3;... 81 3e-14
UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 80 9e-14
UniRef50_Q0X0C1 Cluster: Putative dehydrogenase; n=1; Streptomyc... 79 2e-13
UniRef50_Q44471 Cluster: Probable tartrate dehydrogenase/decarbo... 79 2e-13
UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1; Ent... 78 4e-13
UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9; Eut... 76 1e-12
UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular ... 74 6e-12
UniRef50_A7GLU7 Cluster: Tartrate dehydrogenase; n=3; Bacteria|R... 74 6e-12
UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase; n... 73 8e-12
UniRef50_Q13FQ0 Cluster: Tartrate dehydrogenase; n=3; Proteobact... 73 1e-11
UniRef50_Q8DTG3 Cluster: 3-isopropylmalate dehydrogenase; n=41; ... 71 4e-11
UniRef50_Q1IZK2 Cluster: 3-isopropylmalate dehydrogenase; n=3; B... 69 2e-10
UniRef50_Q8E9N3 Cluster: 3-isopropylmalate dehydrogenase; n=148;... 67 7e-10
UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1; S... 66 2e-09
UniRef50_Q03UM1 Cluster: 3-isopropylmalate dehydrogenase; n=2; L... 65 2e-09
UniRef50_A5DIP7 Cluster: Putative uncharacterized protein; n=1; ... 65 2e-09
UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: Leu... 65 3e-09
UniRef50_Q8A6M0 Cluster: 3-isopropylmalate dehydrogenase; n=42; ... 65 3e-09
UniRef50_Q0W5L4 Cluster: 3-isopropylmalate dehydrogenase; n=10; ... 64 5e-09
UniRef50_A0P1S6 Cluster: 3-isopropylmalate dehydrogenase; n=2; R... 63 8e-09
UniRef50_Q48806 Cluster: Protein dlpA; n=4; Legionella pneumophi... 63 1e-08
UniRef50_A6GJ83 Cluster: Isocitrate dehydrogenase; n=1; Plesiocy... 62 2e-08
UniRef50_Q89RJ1 Cluster: 3-isopropylmalate dehydrogenase; n=7; A... 62 2e-08
UniRef50_Q8YCX4 Cluster: 3-isopropylmalate dehydrogenase; n=126;... 61 3e-08
UniRef50_Q1IMD5 Cluster: 3-isopropylmalate dehydrogenase; n=1; A... 60 1e-07
UniRef50_Q81T67 Cluster: 3-isopropylmalate dehydrogenase; n=9; B... 60 1e-07
UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2; Bacillacea... 58 2e-07
UniRef50_Q67LW7 Cluster: Tartrate dehydrogenase; n=2; Bacteria|R... 58 3e-07
UniRef50_Q4V533 Cluster: IP13250p; n=4; Drosophila melanogaster|... 58 3e-07
UniRef50_Q7UTP0 Cluster: 3-isopropylmalate dehydrogenase; n=2; B... 57 7e-07
UniRef50_Q7VH33 Cluster: 3-isopropylmalate dehydrogenase; n=11; ... 56 1e-06
UniRef50_Q9FMT1 Cluster: 3-isopropylmalate dehydrogenase 3, chlo... 54 4e-06
UniRef50_P56471 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 54 5e-06
UniRef50_Q2JTN8 Cluster: 3-isopropylmalate dehydrogenase; n=72; ... 53 9e-06
UniRef50_A6PN62 Cluster: 3-isopropylmalate dehydrogenase; n=1; V... 52 2e-05
UniRef50_Q300E7 Cluster: Isocitrate/isopropylmalate dehydrogenas... 52 2e-05
UniRef50_P04173 Cluster: 3-isopropylmalate dehydrogenase; n=41; ... 52 3e-05
UniRef50_Q89XA0 Cluster: 3-isopropylmalate dehydrogenase 1; n=3;... 51 5e-05
UniRef50_Q12545 Cluster: 3-isopropylmalate dehydrogenase; n=2; H... 50 6e-05
UniRef50_Q05FQ8 Cluster: 3-isopropylmalate dehydrogenase; n=1; C... 50 8e-05
UniRef50_A6G3V7 Cluster: Probable 3-isopropylmalate dehydrogenas... 50 1e-04
UniRef50_Q7UIE1 Cluster: 3-isopropylmalate dehydrogenase; n=4; B... 49 1e-04
UniRef50_UPI00003C8595 Cluster: hypothetical protein Faci_030007... 48 3e-04
UniRef50_Q2Q9C5 Cluster: Isocitrate dehydrogenase 3 gamma; n=8; ... 48 3e-04
UniRef50_A0ZF75 Cluster: 3-isopropylmalate dehydrogenase; n=2; N... 48 4e-04
UniRef50_Q08522 Cluster: Putative uncharacterized protein YOR135... 47 8e-04
UniRef50_A1SWV5 Cluster: 3-isopropylmalate dehydrogenase; n=1; P... 46 0.001
UniRef50_Q12592 Cluster: 3-isopropylmalate dehydrogenase; n=3; A... 46 0.001
UniRef50_Q6L0K7 Cluster: 3-isopropylmalate dehydrogenase; n=2; T... 46 0.001
UniRef50_Q3ZXI7 Cluster: 3-isopropylmalate dehydrogenase; n=66; ... 46 0.002
UniRef50_Q5IWY1 Cluster: Plastid 3-isopropylmalate dehydrogenase... 43 0.012
UniRef50_Q5A9E0 Cluster: Putative uncharacterized protein; n=1; ... 42 0.016
UniRef50_A1WV93 Cluster: 3-isopropylmalate dehydrogenase; n=7; G... 42 0.022
UniRef50_Q6B458 Cluster: 3-isopropylmalate dehydrogenase; n=30; ... 42 0.022
UniRef50_O59930 Cluster: 3-isopropylmalate dehydrogenase; n=3; D... 42 0.028
UniRef50_P41566 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 39 0.15
UniRef50_A0Q405 Cluster: 3-isopropylmalate dehydrogenase; n=5; F... 38 0.27
UniRef50_Q4P2R4 Cluster: Putative uncharacterized protein; n=1; ... 38 0.27
UniRef50_A2E7S3 Cluster: Putative uncharacterized protein; n=1; ... 36 1.1
UniRef50_Q8WWQ4 Cluster: Mucin 5; n=5; Catarrhini|Rep: Mucin 5 -... 36 1.1
UniRef50_O59395 Cluster: Putative uncharacterized protein PH1723... 36 1.1
UniRef50_P34738 Cluster: 3-isopropylmalate dehydrogenase; n=5; S... 36 1.4
UniRef50_Q6AGK4 Cluster: Putative uncharacterized protein; n=1; ... 35 2.5
UniRef50_Q6JAD6 Cluster: Putative uncharacterized protein; n=1; ... 35 2.5
UniRef50_A5FB87 Cluster: Von Willebrand factor, type A precursor... 34 4.3
UniRef50_A3DDD4 Cluster: Phage integrase; n=5; Clostridia|Rep: P... 34 4.3
UniRef50_P56472 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 34 4.3
UniRef50_A2TU03 Cluster: Ribonuclease HII; n=1; Dokdonia donghae... 34 5.7
UniRef50_Q7RB56 Cluster: Fulmal1; n=2; Plasmodium (Vinckeia)|Rep... 34 5.7
UniRef50_A7SWW3 Cluster: Predicted protein; n=1; Nematostella ve... 34 5.7
UniRef50_Q2UNH1 Cluster: Predicted protein; n=2; Trichocomaceae|... 34 5.7
UniRef50_Q8R6G0 Cluster: Glycosyl transferase; n=1; Fusobacteriu... 33 7.5
UniRef50_Q62HK9 Cluster: Putative uncharacterized protein; n=15;... 33 7.5
UniRef50_Q9RA19 Cluster: ORF10; n=1; Moritella marina|Rep: ORF10... 33 7.5
UniRef50_Q1QFN8 Cluster: Glycosidase, PH1107-related; n=2; Brady... 33 7.5
UniRef50_Q2VF40 Cluster: Isocitrate dehydrogenase 3 gamma subuni... 33 7.5
UniRef50_Q8D4B1 Cluster: Putative uncharacterized protein; n=2; ... 33 10.0
UniRef50_Q5NXI3 Cluster: Putative uncharacterized protein; n=1; ... 33 10.0
UniRef50_A4M233 Cluster: Putative uncharacterized protein precur... 33 10.0
>UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH); n=6;
Eukaryota|Rep: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Caenorhabditis elegans
Length = 358
Score = 313 bits (769), Expect = 4e-84
Identities = 155/224 (69%), Positives = 180/224 (80%), Gaps = 1/224 (0%)
Frame = +3
Query: 111 MAARIIRKIVPATRAGAAQYSTG-VRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEV 287
M + I+K +T + +YS+G VR+VTLIPG GIGPEI+ +VQKIFEAA PI W+ V
Sbjct: 1 MLGKCIKK-ASSTVGQSIRYSSGDVRRVTLIPGDGIGPEISASVQKIFEAADAPIAWDPV 59
Query: 288 DVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRP 467
DVT V+G DG F IP + I+ ++ANK+GLKGPL TP+GKG+RSLNLA+RKEF LYANVRP
Sbjct: 60 DVTPVKGRDGVFRIPSRCIELMHANKVGLKGPLETPIGKGHRSLNLAVRKEFSLYANVRP 119
Query: 468 CKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQF 647
C+SLEG KTLYDNVDVVTIRENTEGEYSGIEHEIV GVVQSIKLITE AS VA FAF++
Sbjct: 120 CRSLEGHKTLYDNVDVVTIRENTEGEYSGIEHEIVPGVVQSIKLITETASRNVASFAFEY 179
Query: 648 ARENKRKKVTAVHKANIMRMSDGLFLRCCRELATKYPGHQVRRA 779
AR+N RK VTAVHKANIMR SDGLFL CRE A YP + + A
Sbjct: 180 ARQNGRKVVTAVHKANIMRQSDGLFLSICREQAALYPDIKFKEA 223
Score = 35.9 bits (79), Expect = 1.4
Identities = 16/25 (64%), Positives = 17/25 (68%)
Frame = +1
Query: 760 DIKFEERYLDTVCLXMVXXPDPXXV 834
DIKF+E YLDTVCL MV P V
Sbjct: 217 DIKFKEAYLDTVCLNMVQDPSQYDV 241
>UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=62;
Eukaryota|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Homo sapiens
(Human)
Length = 366
Score = 288 bits (706), Expect = 2e-76
Identities = 136/193 (70%), Positives = 163/193 (84%)
Frame = +3
Query: 168 YSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAID 347
++ GV+ VTLIPG GIGPEI+ AV KIF+AAK PI+WEE +VTA++GP GK+ IP +A +
Sbjct: 27 FTGGVQTVTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPSEAKE 86
Query: 348 SVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIR 527
S++ NK+GLKGPL TP+ G+ S+NL LRK FDLYANVRPC S+EG KT Y +V++VTIR
Sbjct: 87 SMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIR 146
Query: 528 ENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRM 707
ENTEGEYSGIEH IVDGVVQSIKLITE AS R+AEFAF++AR N R VTAVHKANIMRM
Sbjct: 147 ENTEGEYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTAVHKANIMRM 206
Query: 708 SDGLFLRCCRELA 746
SDGLFL+ CRE+A
Sbjct: 207 SDGLFLQKCREVA 219
Score = 36.3 bits (80), Expect = 1.1
Identities = 16/26 (61%), Positives = 17/26 (65%)
Frame = +1
Query: 757 RDIKFEERYLDTVCLXMVXXPDPXXV 834
+DIKF E YLDTVCL MV P V
Sbjct: 223 KDIKFNEMYLDTVCLNMVQDPSQFDV 248
>UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalytic
subunit 6, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 6) (NAD(+)-specific ICDH 6);
n=10; cellular organisms|Rep: Isocitrate dehydrogenase
[NAD] catalytic subunit 6, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 6) (NAD(+)-specific
ICDH 6) - Arabidopsis thaliana (Mouse-ear cress)
Length = 374
Score = 248 bits (607), Expect = 1e-64
Identities = 115/191 (60%), Positives = 148/191 (77%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 365
K TL PG GIGPEI +V+++F AA V I+W+E V P + + SV NK
Sbjct: 45 KATLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFVGTEVDPRTNSFLTWDNLQSVLKNK 104
Query: 366 IGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGE 545
+GLKGP+ TP+GKG+RSLNL LRKE +LYANVRPC SL G KT YD+VD++TIRENTEGE
Sbjct: 105 VGLKGPMATPIGKGHRSLNLTLRKELNLYANVRPCYSLPGYKTRYDDVDLITIRENTEGE 164
Query: 546 YSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSDGLFL 725
YSG+EH++V GVV+S+K+IT +AS RVAE+AF +A+ + RKKV+A+HKANIM+ +DGLFL
Sbjct: 165 YSGLEHQVVKGVVESLKIITRKASMRVAEYAFLYAKTHGRKKVSAIHKANIMQKTDGLFL 224
Query: 726 RCCRELATKYP 758
+CC E+A KYP
Sbjct: 225 QCCDEVAAKYP 235
>UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=31; cellular
organisms|Rep: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 369
Score = 239 bits (584), Expect = 9e-62
Identities = 121/237 (51%), Positives = 155/237 (65%)
Frame = +3
Query: 156 GAAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQ 335
G STG V+ I G GIGPEI+ +V+KIF AA VPIEWE DV+ + +G IP
Sbjct: 28 GKPNPSTGKYTVSFIEGDGIGPEISKSVKKIFSAANVPIEWESCDVSPIF-VNGLTTIPD 86
Query: 336 KAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDV 515
A+ S+ N + LKGPL TP+GKG+RSLNL LRK F L+ANVRP KS+EG KT Y+NVD+
Sbjct: 87 PAVQSITKNLVALKGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGFKTTYENVDL 146
Query: 516 VTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKAN 695
V IRENTEGEYSGIEH + GVVQSIKLIT +AS RV +AF++AR R +V VHK+
Sbjct: 147 VLIRENTEGEYSGIEHIVCPGVVQSIKLITRDASERVIRYAFEYARAIGRPRVIVVHKST 206
Query: 696 IMRMSDGLFLRCCRELATKYPGHQVRRAIPGHGLPXHGXXTRPXXSLTXXGXCPTLF 866
I R++DGLF+ +EL+ +YP + + + + T P CP L+
Sbjct: 207 IQRLADGLFVNVAKELSKEYPDLTLETELIDNSVLK--VVTNPSAYTDAVSVCPNLY 261
>UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3;
Bacteria|Rep: Isocitrate dehydrogenase - Acidobacteria
bacterium (strain Ellin345)
Length = 348
Score = 231 bits (566), Expect = 1e-59
Identities = 104/191 (54%), Positives = 143/191 (74%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 365
K+TLIPG GIGPE+T A ++ EA + EWE A K IP++ +S+ +
Sbjct: 4 KITLIPGDGIGPEVTSAAVRVLEATGLKFEWESFAAGAEAYEKYKEYIPKELNESIERTR 63
Query: 366 IGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGE 545
IGLKGP+ TP+G G+ S+N+ LRK F+LYANVRP ++L G+ T Y VD+V +RENTEG
Sbjct: 64 IGLKGPVTTPIGGGFSSINVELRKRFELYANVRPIRNLPGVHTRYPGVDLVVVRENTEGL 123
Query: 546 YSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSDGLFL 725
YSGIEHE+V GVV+S+K+ITE+ASTR+++FAF +AR+ RKK+ ++HKANIM+MSDGLF+
Sbjct: 124 YSGIEHEVVPGVVESLKIITEKASTRISKFAFNYARKMGRKKIHSIHKANIMKMSDGLFI 183
Query: 726 RCCRELATKYP 758
RC R ++ +YP
Sbjct: 184 RCSRNISKEYP 194
>UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 394
Score = 220 bits (538), Expect = 3e-56
Identities = 106/203 (52%), Positives = 147/203 (72%), Gaps = 4/203 (1%)
Frame = +3
Query: 162 AQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTA--VRGPDGKFGIPQ 335
A+Y G VTLIPG GIGPE+ VAVQ IF VP+++EE++++ ++ D G
Sbjct: 45 ARYG-GRNTVTLIPGDGIGPEMVVAVQDIFRHIGVPVDFEELNLSGLDIKDEDSYLGAFN 103
Query: 336 KAIDSVNANKIGLKGPLMTPVGK--GYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNV 509
+AI S+ N + +KG + TP+ G+RSLNL LR DL+AN+ CKS+ GI+T ++NV
Sbjct: 104 EAITSIKRNGVAMKGNIFTPLDAIPGFRSLNLELRVHLDLFANIVRCKSIPGIQTRHNNV 163
Query: 510 DVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHK 689
D+V IR+NTEGEYS +EHE V GV++++K+ TEEA ++A++AF FA ++ RKKVTAVHK
Sbjct: 164 DLVIIRQNTEGEYSHLEHENVSGVIENLKVTTEEACMKIAQYAFDFAEKHDRKKVTAVHK 223
Query: 690 ANIMRMSDGLFLRCCRELATKYP 758
ANIM+M DGLFLRCC E++ YP
Sbjct: 224 ANIMKMGDGLFLRCCEEMSHSYP 246
>UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 1) (NAD(+)-specific ICDH 1);
n=7; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 1, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 1) (NAD(+)-specific
ICDH 1) - Arabidopsis thaliana (Mouse-ear cress)
Length = 367
Score = 219 bits (534), Expect = 1e-55
Identities = 106/192 (55%), Positives = 144/192 (75%)
Frame = +3
Query: 183 RKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNAN 362
R VTLIPG GIGP +T AV+++ EA PI +E+ DV G + +P + ++S+ N
Sbjct: 38 RAVTLIPGDGIGPLVTNAVEQVMEAMHAPIFFEKYDV---HGEMSR--VPPEVMESIRKN 92
Query: 363 KIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEG 542
K+ LKG L TPVG G SLN+ LRKE DL+A++ C +L G+ T ++NVD+V IRENTEG
Sbjct: 93 KVCLKGGLKTPVGGGVSSLNVQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEG 152
Query: 543 EYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSDGLF 722
EY+G+EHE+V GVV+S+K+IT+ S R+A++AF++A N RKKVTAVHKANIM+++DGLF
Sbjct: 153 EYAGLEHEVVPGVVESLKVITKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLF 212
Query: 723 LRCCRELATKYP 758
L CRE+A KYP
Sbjct: 213 LESCREVAKKYP 224
>UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 3, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 3) (NAD(+)-specific ICDH 3);
n=23; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 3, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 3) (NAD(+)-specific
ICDH 3) - Arabidopsis thaliana (Mouse-ear cress)
Length = 368
Score = 215 bits (526), Expect = 1e-54
Identities = 105/193 (54%), Positives = 142/193 (73%)
Frame = +3
Query: 183 RKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNAN 362
R VTLIPG GIGP +T AV+++ EA P+ +E +V G K +P++ I+SV N
Sbjct: 39 RTVTLIPGDGIGPLVTGAVEQVMEAMHAPVHFERYEVL---GNMRK--VPEEVIESVKRN 93
Query: 363 KIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEG 542
K+ LKG L TPVG G SLN+ LRKE D++A++ C ++ G+ T ++NVD+V IRENTEG
Sbjct: 94 KVCLKGGLATPVGGGVSSLNMQLRKELDIFASLVNCINVPGLVTRHENVDIVVIRENTEG 153
Query: 543 EYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSDGLF 722
EYSG+EHE+V GVV+S+K+IT+ S R+A +AF++A N RKKVTAVHKANIM+++DGLF
Sbjct: 154 EYSGLEHEVVPGVVESLKVITKFCSERIARYAFEYAYLNNRKKVTAVHKANIMKLADGLF 213
Query: 723 LRCCRELATKYPG 761
L CRE+A Y G
Sbjct: 214 LESCREVAKHYSG 226
>UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1;
Kluyveromyces lactis|Rep: Isocitrate dehydrogenase [NAD]
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Kluyveromyces lactis (Yeast) (Candida sphaerica)
Length = 361
Score = 208 bits (507), Expect = 2e-52
Identities = 102/200 (51%), Positives = 140/200 (70%), Gaps = 2/200 (1%)
Frame = +3
Query: 189 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKI 368
VTLIPG G+G E+T +V KIFE +PI+WE +D++ + + Q+A++S+ NK+
Sbjct: 32 VTLIPGDGVGKEVTDSVVKIFENENIPIDWETIDISGLENTENV----QRAVESLKRNKV 87
Query: 369 GLKGPLMTPVGK-GYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGE 545
GLKG TP + G+ SLN+ALRK+ D++ANV KS+ G+KT +N+D+V IRENTEGE
Sbjct: 88 GLKGIWHTPADQTGHGSLNVALRKQLDIFANVALFKSIPGVKTRLNNIDMVIIRENTEGE 147
Query: 546 YSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSDGLFL 725
YSG+EHE V GVV+S+K++T S R+A FAF FA +N RK V AVHKANIM++ DGLF
Sbjct: 148 YSGLEHESVPGVVESLKIMTRAKSERIARFAFDFALKNNRKSVCAVHKANIMKLGDGLFR 207
Query: 726 RCCREL-ATKYPGHQVRRAI 782
E+ A +YP V+ I
Sbjct: 208 NTVNEIGANEYPELDVKNII 227
>UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=32;
Dikarya|Rep: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 360
Score = 204 bits (498), Expect = 2e-51
Identities = 109/226 (48%), Positives = 150/226 (66%), Gaps = 2/226 (0%)
Frame = +3
Query: 111 MAARIIRKIVPATRAGAAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVD 290
+A R + A R +Y G VTLIPG G+G EIT +V+ IFEA +PI+WE ++
Sbjct: 6 IAKRTLATAAQAERTLPKKYG-GRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETIN 64
Query: 291 VTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGK-GYRSLNLALRKEFDLYANVRP 467
+ + D K G+ +A++S+ NKIGLKG TP + G+ SLN+ALRK+ D+YANV
Sbjct: 65 I---KQTDHKEGV-YEAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVAL 120
Query: 468 CKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQF 647
KSL+G+KT ++D++ IRENTEGE+SG+EHE V GVV+S+K++T + R+A FAF F
Sbjct: 121 FKSLKGVKTRIPDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDF 180
Query: 648 ARENKRKKVTAVHKANIMRMSDGLFLRCCRELATK-YPGHQVRRAI 782
A++ RK VTAVHKANIM++ DGLF E+ K YP V I
Sbjct: 181 AKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSII 226
>UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=50;
Deuterostomia|Rep: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 393
Score = 199 bits (486), Expect = 7e-50
Identities = 99/202 (49%), Positives = 143/202 (70%), Gaps = 2/202 (0%)
Frame = +3
Query: 159 AAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQK 338
+A+Y G VT+IPG GIGPE+ + V+ +F A VP+++EEV V++ + +
Sbjct: 48 SAKYG-GRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVSSNADEEDI----RN 102
Query: 339 AIDSVNANKIGLKGPLMTP--VGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVD 512
AI ++ N++ LKG + T + ++S N LR DLYANV CKSL G+ T + ++D
Sbjct: 103 AIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKDID 162
Query: 513 VVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKA 692
++ +RENTEGEYS +EHE V GVV+S+K+IT+ S R+AE+AF+ A+E+ RKKVTAVHKA
Sbjct: 163 ILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKA 222
Query: 693 NIMRMSDGLFLRCCRELATKYP 758
NIM++ DGLFL+CCRE+A +YP
Sbjct: 223 NIMKLGDGLFLQCCREVAARYP 244
>UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase family protein; n=9; Bacteria|Rep:
Isopropylmalate/isohomocitrate dehydrogenase family
protein - Synechococcus sp. (strain JA-3-3Ab)
(Cyanobacteria bacteriumYellowstone A-Prime)
Length = 368
Score = 191 bits (465), Expect = 2e-47
Identities = 101/213 (47%), Positives = 143/213 (67%), Gaps = 22/213 (10%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFG--IPQKAIDSVNA 359
+VTLIPG GIGPE+T A+ + EA+ V +EW V+ V + K+G +P + ++S+
Sbjct: 4 RVTLIPGDGIGPEVTRAMTTVLEASGVDLEWIRVEA-GVEVIE-KYGTPLPPQVLESIRE 61
Query: 360 NKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTE 539
++ +KGP+ TPVG G+RS+N+A+RKE DLYAN+RP KSL GIK+ + ++D+V +RENTE
Sbjct: 62 TRVAIKGPIGTPVGTGFRSVNVAIRKELDLYANLRPAKSLPGIKSPFQDIDLVVVRENTE 121
Query: 540 GEYSGIEHE--------------------IVDGVVQSIKLITEEASTRVAEFAFQFAREN 659
Y+GIE E I +G IK I+E S R+ +FAF++AR+N
Sbjct: 122 DLYAGIEFERGTPEAAHAREEMMRLSGKFIREGSAIGIKPISEFGSRRIVKFAFEYARQN 181
Query: 660 KRKKVTAVHKANIMRMSDGLFLRCCRELATKYP 758
RKKVTAVHKANIM+ +DGLFL+ RE+A +YP
Sbjct: 182 GRKKVTAVHKANIMKFTDGLFLQVAREVAQEYP 214
>UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;
Glossina morsitans morsitans|Rep: Isocitrate
dehydrogenase (NAD+) 2 - Glossina morsitans morsitans
(Savannah tsetse fly)
Length = 372
Score = 191 bits (465), Expect = 2e-47
Identities = 96/201 (47%), Positives = 140/201 (69%), Gaps = 4/201 (1%)
Frame = +3
Query: 192 TLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIG 371
TLIPG G+GPE+ +Q++F++A VP+++E ++ V P + + I S+ NK+
Sbjct: 43 TLIPGDGVGPELVQCLQEVFKSADVPVDFECYFLSEVN-PVLSAKL-EDVIASIRKNKVC 100
Query: 372 LKGPLMTP----VGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTE 539
+KG L TP VG+ +SLN+ LR E DLYANV +SL G+KT Y ++D+V IRE TE
Sbjct: 101 IKGVLATPDYSNVGE-LQSLNMKLRNELDLYANVVHARSLPGVKTRYQDIDIVVIREQTE 159
Query: 540 GEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSDGL 719
GEYS +EHE V G+V+ +K+IT + S R+A+FAF +A +N RKKVT+VHKANIM++ DGL
Sbjct: 160 GEYSALEHESVPGIVECLKIITAKKSMRIAKFAFDYAIKNSRKKVTSVHKANIMKLGDGL 219
Query: 720 FLRCCRELATKYPGHQVRRAI 782
FL+ C ++A YP + ++ I
Sbjct: 220 FLKSCEDMAKLYPRIEFQKMI 240
>UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8;
Bilateria|Rep: Isocitrate dehydrogenase - Aedes aegypti
(Yellowfever mosquito)
Length = 393
Score = 189 bits (460), Expect = 1e-46
Identities = 100/199 (50%), Positives = 131/199 (65%), Gaps = 2/199 (1%)
Frame = +3
Query: 177 GVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVT-AVRGPDGKFGIPQKAIDSV 353
G VT++PG GIGPE+ V+++F A VP+++E VD+ A G D + AI S+
Sbjct: 48 GRHTVTMLPGGGIGPELMNYVKEVFRFAGVPVDFEVVDIDPASEGNDDL----EYAITSI 103
Query: 354 NANKIGLKGPLMTPV-GKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRE 530
N + LKG + T G S N+ALR E DLY NV CKS I + NVDVV IR+
Sbjct: 104 KRNGVALKGNIETKSEATGIISRNVALRNELDLYVNVLHCKSFNAIPAHHQNVDVVIIRQ 163
Query: 531 NTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMS 710
NTEGEY+ +EHE V GVV+S+K++T E + RVA +AF+FAR N RKKVT +HKANIM+++
Sbjct: 164 NTEGEYAMLEHESVRGVVESMKVVTVENAARVARYAFEFARANNRKKVTTIHKANIMKLA 223
Query: 711 DGLFLRCCRELATKYPGHQ 767
DGLFL RE+A YP Q
Sbjct: 224 DGLFLSVAREVAKDYPDIQ 242
>UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit
beta, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=61;
Fungi/Metazoa group|Rep: Isocitrate dehydrogenase [NAD]
subunit beta, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 385
Score = 184 bits (447), Expect = 4e-45
Identities = 89/192 (46%), Positives = 134/192 (69%), Gaps = 2/192 (1%)
Frame = +3
Query: 189 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKI 368
VT++PG G+GPE+ AV+++F+AA VP+E++E ++ V+ + + Q + S+ NK+
Sbjct: 51 VTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQ-VLSSMKENKV 109
Query: 369 GLKGPLMTPVG-KG-YRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEG 542
+ G + TP+ KG S ++ LR++ DL+ANV KSL G T ++N+D+V IRE TEG
Sbjct: 110 AIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEG 169
Query: 543 EYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSDGLF 722
EYS +EHE GV++ +K++T S R+A+FAF +A + R KVTAVHKANIM++ DGLF
Sbjct: 170 EYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLF 229
Query: 723 LRCCRELATKYP 758
L+CC E+A YP
Sbjct: 230 LQCCEEVAELYP 241
>UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2;
Bacteria|Rep: Isocitrate dehydrogenase - Gloeobacter
violaceus
Length = 359
Score = 181 bits (440), Expect = 3e-44
Identities = 92/211 (43%), Positives = 136/211 (64%), Gaps = 20/211 (9%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 365
+VTLI G GIGPE+T A + + +A + EW VD A +P I++V A+
Sbjct: 5 RVTLIRGDGIGPEVTQAARIVLDATGIDFEWVVVDAGAEVMEKSGTPLPAPVIEAVRASD 64
Query: 366 IGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGE 545
+KGP+ TP G G RS+N+ALR+ DLYAN+RP ++L G+ + YDN+D+V +RENTE
Sbjct: 65 AAIKGPITTPAGSGIRSVNVALRRALDLYANLRPARTLPGVHSRYDNIDLVVVRENTEDL 124
Query: 546 YSGIEH--------EIVDGVVQ------------SIKLITEEASTRVAEFAFQFARENKR 665
YSGIE E+++ +++ ++K I+ EAS R+A FAF++AR + R
Sbjct: 125 YSGIEFEKNSPQALEVIEMLMRLGGKKIFPRSGLAVKPISSEASERIARFAFEYARRHAR 184
Query: 666 KKVTAVHKANIMRMSDGLFLRCCRELATKYP 758
+KVTAVHKANI++ +DGLFL R++A++YP
Sbjct: 185 RKVTAVHKANILKHTDGLFLEAARQVASEYP 215
>UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p -
Drosophila melanogaster (Fruit fly)
Length = 402
Score = 179 bits (436), Expect = 8e-44
Identities = 95/212 (44%), Positives = 134/212 (63%), Gaps = 1/212 (0%)
Frame = +3
Query: 126 IRKIVPATRAGAAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVR 305
++K V T +AQY G VT++PG GIGPE+ V++IF PI++E +D+
Sbjct: 40 LQKKVTGTDIPSAQYG-GRHAVTMLPGGGIGPELMGYVREIFRYCGAPIDFEVIDIDP-- 96
Query: 306 GPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYR-SLNLALRKEFDLYANVRPCKSLE 482
+G + AI S+ N + LKG + T S N+A+R E DLY NV CKS
Sbjct: 97 STEGNDDLDY-AITSIKRNGVALKGNIETKSQSLTEVSRNVAIRNELDLYVNVVHCKSYP 155
Query: 483 GIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENK 662
GI + ++DVV IR+NT+GEY+ +EHE V G+V+S+K++T E + RVA +AF+FAR+N
Sbjct: 156 GIPARHHDIDVVLIRQNTDGEYAMLEHESVPGIVESMKVVTVENAERVARYAFEFARQNN 215
Query: 663 RKKVTAVHKANIMRMSDGLFLRCCRELATKYP 758
RKKVT +HKANIM++SDGLFL + YP
Sbjct: 216 RKKVTTIHKANIMKLSDGLFLEVANRVHKDYP 247
>UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=5; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) - Thermus
thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Length = 496
Score = 166 bits (403), Expect = 8e-40
Identities = 84/197 (42%), Positives = 121/197 (61%), Gaps = 3/197 (1%)
Frame = +3
Query: 177 GVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDG-KFGIPQKAIDSV 353
G + +T+IPG GIGPE A K+ EAAK P+ +E + A G G+PQ+ I+S+
Sbjct: 18 GRKLITVIPGDGIGPECVEATLKVLEAAKAPLAYEVREAGASVFRRGIASGVPQETIESI 77
Query: 354 NANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN--VDVVTIR 527
++ LKGPL TPVG G +S N+ LRK F+ YANVRP + + T Y +D+V +R
Sbjct: 78 RKTRVVLKGPLETPVGYGEKSANVTLRKLFETYANVRPVREFPNVPTPYAGRGIDLVVVR 137
Query: 528 ENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRM 707
EN E Y+GIEH V Q++KLI+ + S ++ FAF+ AR RKKV K+NIM++
Sbjct: 138 ENVEDLYAGIEHMQTPSVAQTLKLISWKGSEKIVRFAFELARAEGRKKVHCATKSNIMKL 197
Query: 708 SDGLFLRCCRELATKYP 758
++G R ++A +YP
Sbjct: 198 AEGTLKRAFEQVAQEYP 214
>UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep:
CG3483 protein - Drosophila melanogaster (Fruit fly)
Length = 391
Score = 165 bits (402), Expect = 1e-39
Identities = 87/204 (42%), Positives = 124/204 (60%)
Frame = +3
Query: 144 ATRAGAAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKF 323
A AG+ + KVTLI G G+G E+ AVQ++ A K PIEW+ D + D
Sbjct: 57 AKSAGSTDSAKKTTKVTLINGEGVGRELMDAVQEVICAVKAPIEWDVHDEFKAKDSDD-- 114
Query: 324 GIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYD 503
+ + + S+ ANK+G+KGP+ + R +RK+F +A V C +EG+ + Y
Sbjct: 115 -VSPEVLKSLRANKVGIKGPVDS------RHWQRQIRKQFAQFAYVSLCSHIEGLDSPYG 167
Query: 504 NVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAV 683
+ DVV IR+ EG+YSGIEH +V GV+Q+IK+ T + R+AEF F +A +NKRK++T
Sbjct: 168 DFDVVIIRDQMEGDYSGIEHLVVPGVMQTIKVSTTAGAARIAEFVFNYAVKNKRKRITVA 227
Query: 684 HKANIMRMSDGLFLRCCRELATKY 755
HKANIMRM+DG FL R A K+
Sbjct: 228 HKANIMRMTDGNFLEAMRAEADKH 251
>UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1;
Planctomyces maris DSM 8797|Rep: Isocitrate
dehydrogenase, putative - Planctomyces maris DSM 8797
Length = 390
Score = 158 bits (384), Expect = 2e-37
Identities = 85/216 (39%), Positives = 131/216 (60%), Gaps = 26/216 (12%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 365
KVTLIPG G+GPEI A +K +A V I+W+ V + + + G+P + +DS+ ANK
Sbjct: 3 KVTLIPGDGVGPEIAEATRKCVDATGVKIDWD-VQECGIEVIEAEGGVPDRVMDSIRANK 61
Query: 366 IGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY--DNVDVVTIRENTE 539
I LK P+ TP+GKG+RS+N+ LR+E LYA +RPCK+ +G++T + NVD+V +RENTE
Sbjct: 62 IALKAPITTPIGKGFRSVNVFLRQELGLYACIRPCKTYKGVRTYFADSNVDLVVVRENTE 121
Query: 540 GEYSGIEHEI------------------------VDGVVQSIKLITEEASTRVAEFAFQF 647
Y+G+E + +D SIK ++ + + + +AF++
Sbjct: 122 DLYAGVEFQAGQEKTAELIKKINEFATGKKINTPLDETGVSIKPMSYQGTRDICNYAFKY 181
Query: 648 ARENKRKKVTAVHKANIMRMSDGLFLRCCRELATKY 755
A +NKR+ VT++ KANIM+ +DGL+ R +A Y
Sbjct: 182 AVDNKRQSVTSICKANIMKFTDGLWYDETRAVAKAY 217
>UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68;
Bacteria|Rep: Isocitrate dehydrogenase -
Janthinobacterium sp. (strain Marseille) (Minibacterium
massiliensis)
Length = 349
Score = 157 bits (380), Expect = 5e-37
Identities = 83/196 (42%), Positives = 118/196 (60%), Gaps = 7/196 (3%)
Frame = +3
Query: 189 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWE--EVDVTAVRGPDGKFGIPQKAIDSVNAN 362
VTLIPG GIGPEI V ++F+A P WE + V A+ G +PQ +DS+
Sbjct: 12 VTLIPGDGIGPEIVDVVVRVFDALGNPFAWETQQAGVNALE-KSGDL-LPQTTLDSIGRT 69
Query: 363 KIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEG 542
+ LKGPL TP+G G+RS+N+ LR+ F LYANVRP +++ Y+ +D+V +REN EG
Sbjct: 70 GLALKGPLSTPIGGGFRSVNVRLRETFQLYANVRPARTIVP-GGRYEKIDLVLVRENLEG 128
Query: 543 EYSGIEHEIVDG-----VVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRM 707
Y G EH + G V + + T S R+++FAF +A N R+KVT VHKAN+++
Sbjct: 129 LYVGHEHYVPIGDDAHAVAMATGINTRAGSRRISKFAFDYAVRNNRRKVTIVHKANVLKA 188
Query: 708 SDGLFLRCCRELATKY 755
GLFL +++ Y
Sbjct: 189 LTGLFLETAKQVGLNY 204
>UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=6; Rickettsiales|Rep: Isocitrate dehydrogenase,
NADP-dependent - Orientia tsutsugamushi (strain Boryong)
(Rickettsia tsutsugamushi)
Length = 519
Score = 148 bits (358), Expect = 2e-34
Identities = 78/196 (39%), Positives = 113/196 (57%), Gaps = 2/196 (1%)
Frame = +3
Query: 189 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDV-TAVRGPDGKFGIPQKAIDSVNANK 365
VT+ G GIGPEI AV + + A VP+ E +++ + +GI + + K
Sbjct: 7 VTIAYGDGIGPEIMEAVVYVLKEAAVPLRLETIEIGEKLYNKYYTYGITEDTWSQIFRTK 66
Query: 366 IGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRP-CKSLEGIKTLYDNVDVVTIRENTEG 542
LKGP+ TP G GY+SLN+ LRK LYANVRP C + T +DVV IREN E
Sbjct: 67 ALLKGPVTTPQGGGYKSLNVTLRKTLGLYANVRPSCSYFPFVNTSAPEIDVVIIRENEED 126
Query: 543 EYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSDGLF 722
Y+GIE+ +S+KLI+ S ++ FAF++A +N RK ++ K NIM+ +DG+F
Sbjct: 127 LYAGIEYHHTADTYESVKLISRSGSEKIIRFAFEYALKNNRKTISCFSKDNIMKFTDGIF 186
Query: 723 LRCCRELATKYPGHQV 770
+ E+A++Y QV
Sbjct: 187 HKTFNEIASQYSNIQV 202
>UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3;
Rickettsiales|Rep: Isocitrate dehydrogenase - Anaplasma
marginale (strain St. Maries)
Length = 488
Score = 147 bits (357), Expect = 3e-34
Identities = 77/192 (40%), Positives = 116/192 (60%), Gaps = 2/192 (1%)
Frame = +3
Query: 189 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVR-GPDGKFGIPQKAIDSVNANK 365
+T+ G G+GPEI AV I + A+ + E VD+ + + GI A +S++ +
Sbjct: 10 ITVAYGDGVGPEIMEAVLFILKEARADVSIETVDIGHNQYKKEWTSGIAPSAWESISRTR 69
Query: 366 IGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKS-LEGIKTLYDNVDVVTIRENTEG 542
+ LK P MTP G G++SLN+ALR+ LY NVRPC S + T + ++DVV IREN E
Sbjct: 70 LLLKAPTMTPQGSGHKSLNVALRQRLGLYVNVRPCVSYFPVVGTKHPDLDVVIIRENEED 129
Query: 543 EYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSDGLF 722
YSG+EH++ + + +K+ T AS ++ +AF +AR + RKKVT K NIM+M+DG+
Sbjct: 130 TYSGVEHKLSEDTHECVKISTRSASEKICAYAFNYARAHNRKKVTCFVKDNIMKMTDGIL 189
Query: 723 LRCCRELATKYP 758
++A YP
Sbjct: 190 HASFDKVAKGYP 201
>UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Thermoprotei|Rep: 3-isopropylmalate dehydrogenase -
Sulfolobus tokodaii
Length = 337
Score = 146 bits (354), Expect = 7e-34
Identities = 82/189 (43%), Positives = 113/189 (59%), Gaps = 4/189 (2%)
Frame = +3
Query: 189 VTLIPGHGIGPEITVA----VQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVN 356
V LI G GIGPEI + KI E +PIE+ EV+ +P+ ++ ++
Sbjct: 5 VALIQGDGIGPEIVSKSKRILAKINELYSLPIEYIEVEAGDRALARYGEALPKDSLKIID 64
Query: 357 ANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENT 536
I LKGP VG+ + + LR+ +D+YAN+RP KS+ GI T Y NVD++ +RENT
Sbjct: 65 KADIILKGP----VGESAADVVVKLRQIYDMYANIRPAKSIPGIDTKYGNVDILIVRENT 120
Query: 537 EGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSDG 716
E Y G EH + DGV +K+IT AS R+A+ FA +RKKVT VHKAN+MR++DG
Sbjct: 121 EDLYKGFEHIVSDGVAVGMKIITRFASERIAKVGLNFAL-RRRKKVTCVHKANVMRITDG 179
Query: 717 LFLRCCREL 743
LF CR +
Sbjct: 180 LFAEACRSV 188
>UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
- Archaeoglobus fulgidus
Length = 326
Score = 141 bits (342), Expect = 2e-32
Identities = 75/193 (38%), Positives = 112/193 (58%)
Frame = +3
Query: 180 VRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNA 359
++K+ +IPG GIG E+ A I E +P E+ D +P + +++
Sbjct: 1 MKKIVVIPGDGIGKEVMEAAMLILEKLDLPFEYSYYDAGDEALEKYGKALPDETLEACRK 60
Query: 360 NKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTE 539
+ L G G+ + + LR+E +ANVRP K++EGI+ LY +D+V +RENTE
Sbjct: 61 SDAVLFGA----AGETAADVIVRLRRELGTFANVRPAKAIEGIECLYPGLDIVVVRENTE 116
Query: 540 GEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSDGL 719
Y G E D V ++I++IT EAS R+A +AF+ A+ RKKVTA+HKAN+M+ + GL
Sbjct: 117 CLYMGFEFGFGD-VTEAIRVITREASERIARYAFELAKREGRKKVTALHKANVMKKTCGL 175
Query: 720 FLRCCRELATKYP 758
F CRE+A YP
Sbjct: 176 FRDVCREVAKDYP 188
>UniRef50_Q4UKR1 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=29; cellular organisms|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Rickettsia felis (Rickettsia azadi)
Length = 483
Score = 141 bits (341), Expect = 3e-32
Identities = 75/192 (39%), Positives = 114/192 (59%), Gaps = 2/192 (1%)
Frame = +3
Query: 189 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDV-TAVRGPDGKFGIPQKAIDSVNANK 365
+T+ G GIGPEI AV I A+ I E ++V + GI +++ +S+
Sbjct: 7 ITIAYGDGIGPEIMEAVLYILRKAEARIRLETIEVGEKLYKKHYTSGISEESWESIQRTG 66
Query: 366 IGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIK-TLYDNVDVVTIRENTEG 542
I LK P+ TP G GY+SLN+ +RK L+AN+RP S TL+ ++++ IREN E
Sbjct: 67 IILKAPITTPQGGGYKSLNVTIRKTLQLFANIRPSVSFHPFTMTLHPHLNLTIIRENEED 126
Query: 543 EYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSDGLF 722
Y+GIE+ + +SIKLI+ ++ +AF++A +N RKKVT + K NIM+ SDG+F
Sbjct: 127 LYAGIEYRQTHNMYESIKLISHTGCEKIIRYAFEYAVKNNRKKVTCLSKDNIMKFSDGVF 186
Query: 723 LRCCRELATKYP 758
+ E+A +YP
Sbjct: 187 HKIFNEIAKEYP 198
>UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase; n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Isopropylmalate/isohomocitrate dehydrogenase -
Candidatus Nitrosopumilus maritimus SCM1
Length = 337
Score = 135 bits (327), Expect = 1e-30
Identities = 73/194 (37%), Positives = 120/194 (61%), Gaps = 3/194 (1%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAI--DSVNA 359
K++LI G GIGPE++ + + E ++ + +T + D KA+ D+V+A
Sbjct: 3 KISLITGDGIGPELSDSAVSVLETIHDKLDLK-FGITKLSAGDKALEQTGKALPDDTVSA 61
Query: 360 NKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTE 539
K + PVG+ + + LR+ DLYAN+RP KS + L D++D+V +RENTE
Sbjct: 62 IKQS-DACMKAPVGESAADVIVVLRRMLDLYANIRPAKSYPHMPALRDDIDMVIVRENTE 120
Query: 540 GEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFAR-ENKRKKVTAVHKANIMRMSDG 716
Y+G E + D V ++++I+E+AS R+A++AF+ A+ N +KKVT VHK+N+MR++DG
Sbjct: 121 DLYTGKEFSLGDSSV-ALRIISEQASKRIAKYAFETAKMRNDKKKVTCVHKSNVMRVTDG 179
Query: 717 LFLRCCRELATKYP 758
+F + C E++ YP
Sbjct: 180 MFAKACTEVSKDYP 193
>UniRef50_Q2UP37 Cluster: Isocitrate/isopropylmalate dehydrogenase;
n=1; Aspergillus oryzae|Rep: Isocitrate/isopropylmalate
dehydrogenase - Aspergillus oryzae
Length = 350
Score = 131 bits (317), Expect = 2e-29
Identities = 71/205 (34%), Positives = 117/205 (57%), Gaps = 14/205 (6%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 365
++ ++ G+GIGPEIT A ++ EA + EW+ + + +P + I + K
Sbjct: 2 RIGVLKGNGIGPEITAATIRVIEATGIQPEWDFIPIADEAVRLYGHALPPQVIQRIKDVK 61
Query: 366 IGLKGPLMTPVGKG-------------YRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN 506
+K PL+ G Y S+N A+R+E +L+ N RP + GI ++
Sbjct: 62 FCIKAPLLAEKLHGRISCTQTDGSVVTYPSINNAIRRELNLFVNPRPIRGYVGISGRHEK 121
Query: 507 VDVVTIRENTEGEYSGIEHEIVDGVV-QSIKLITEEASTRVAEFAFQFARENKRKKVTAV 683
+D+V +RE TE Y G E + DG ++IK +T AS +V+++AF++AR++ RKKV+ +
Sbjct: 122 MDMVIMREITEDTYIGWEKPLEDGAAAEAIKRVTRSASWKVSQYAFEYARKHGRKKVSCL 181
Query: 684 HKANIMRMSDGLFLRCCRELATKYP 758
HKAN++ +DGLFLR +E+A YP
Sbjct: 182 HKANVLHETDGLFLRTFQEVARLYP 206
>UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanobacterium thermoautotrophicum
Length = 329
Score = 130 bits (315), Expect = 4e-29
Identities = 70/191 (36%), Positives = 112/191 (58%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 365
K+ +IPG GIG E+ A I + +E+ D +P++ +++V +
Sbjct: 5 KIAVIPGDGIGVEVMEAALHILNTLDLDLEFIHADAGDACLKRTGTALPEETLEAVGEAR 64
Query: 366 IGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGE 545
L G G+ + + LR+EFDL+AN+RP KSL G+ LY ++D V +RENTE
Sbjct: 65 ATLFGA----AGESAADVIVRLRREFDLFANLRPVKSLPGVPCLYPDLDFVIVRENTEDL 120
Query: 546 YSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSDGLFL 725
Y G E +G V ++IT AS R+++FAFQ+A++ +KVTAVHKAN+++ +DG+F
Sbjct: 121 YVGDEEYTPEGAVAK-RIITRTASRRISQFAFQYAQKEGMQKVTAVHKANVLKKTDGIFR 179
Query: 726 RCCRELATKYP 758
++A++YP
Sbjct: 180 DEFYKVASEYP 190
>UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanococcus jannaschii
Length = 333
Score = 127 bits (307), Expect = 3e-28
Identities = 71/197 (36%), Positives = 113/197 (57%), Gaps = 5/197 (2%)
Frame = +3
Query: 180 VRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDV-TAVRGPDGKFGIPQKAIDSVN 356
+ K+ +I G GIG E+ A ++ EA +P E+ + V GK +P++ I++
Sbjct: 1 MHKICVIEGDGIGKEVVPATIQVLEATGLPFEFVYAEAGDEVYKRTGK-ALPEETIETA- 58
Query: 357 ANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENT 536
+ L G+ + + LR D YAN+RP K+ +G+K L ++D V +RENT
Sbjct: 59 ---LDCDAVLFGAAGETAADVIVKLRHILDTYANIRPVKAYKGVKCLRPDIDYVIVRENT 115
Query: 537 EGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRK----KVTAVHKANIMR 704
EG Y GIE EI +G+ + ++ITE+A R+ FAF ARE K+ KVT HKAN+++
Sbjct: 116 EGLYKGIEAEIDEGITIATRVITEKACERIFRFAFNLARERKKMGKEGKVTCAHKANVLK 175
Query: 705 MSDGLFLRCCRELATKY 755
++DGLF + ++A +Y
Sbjct: 176 LTDGLFKKIFYKVAEEY 192
>UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]
subunit-like 4 (Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4); n=1; Arabidopsis thaliana|Rep:
Putative isocitrate dehydrogenase [NAD] subunit-like 4
(Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4) - Arabidopsis thaliana
(Mouse-ear cress)
Length = 294
Score = 125 bits (302), Expect = 1e-27
Identities = 69/184 (37%), Positives = 113/184 (61%), Gaps = 2/184 (1%)
Frame = +3
Query: 213 IGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMT 392
I +T AV ++ +A + P+ +E ++G + + + +DS+ NK+ L G +
Sbjct: 8 IDSNVTNAVHQVMDAMQAPVYFETY---IIKGKNMNH-LTWEVVDSIRKNKVCLNGRVNN 63
Query: 393 PVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIV 572
+ G RKE DL+A++ C +L G + ++NVD+V IRENTEGEY+G EHE+V
Sbjct: 64 SLCGG-------ARKELDLFASLVDCFNLNGQPSRHENVDIVVIRENTEGEYAGREHEVV 116
Query: 573 DGVVQSIKL-ITEEASTRVAEFAFQFARENKRKKVTAVH-KANIMRMSDGLFLRCCRELA 746
GV++S ++ +T+ S R+A++AF++A +KRKKVTAVH +++D FL C+E+A
Sbjct: 117 PGVIESFQVTMTKFWSDRIAKYAFEYAHFSKRKKVTAVHNNGKYEKLADAFFLESCQEVA 176
Query: 747 TKYP 758
YP
Sbjct: 177 KMYP 180
>UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenase
family protein; n=6; Archaea|Rep:
Isocitrate/isopropylmalate dehydrogenase family protein
- Methanosarcina acetivorans
Length = 342
Score = 119 bits (287), Expect = 9e-26
Identities = 66/199 (33%), Positives = 112/199 (56%), Gaps = 3/199 (1%)
Frame = +3
Query: 183 RKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPD--GKFGIPQKAIDSVN 356
+ +I G G+GPE+ A+ K+ AA +E+ + A + G +P + ++
Sbjct: 3 KTAAVIKGDGVGPELVEAMLKVANAAGTDVEFVMCEAGAGWWEEHGGNSLVPDETWQILD 62
Query: 357 ANKIGLKGPLMTPVGKGY-RSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIREN 533
++ KGP TP G G RS+ +++R+++DLYANVRP K+ +V++V +RE
Sbjct: 63 SSDACFKGPTTTPGGIGSPRSVAVSIRRKYDLYANVRPIKTFPNSNAPLGDVEMVCVREG 122
Query: 534 TEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSD 713
TEG Y G E ++ D V +I+ IT AS ++A +AF+ A+ V +HK+NI++++
Sbjct: 123 TEGLYIGEEIQLTDDVSIAIRKITRTASGKIARYAFEEAKRRGYDTVVPIHKSNILKLTC 182
Query: 714 GLFLRCCRELATKYPGHQV 770
G FL ++A YP +V
Sbjct: 183 GSFLEEVEKVAQDYPNIEV 201
>UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=2; Archaea|Rep: Isocitrate dehydrogenase,
NADP-dependent - Halorubrum lacusprofundi ATCC 49239
Length = 463
Score = 118 bits (285), Expect = 2e-25
Identities = 81/224 (36%), Positives = 114/224 (50%), Gaps = 30/224 (13%)
Frame = +3
Query: 189 VTLIPGHGIGPEITVAVQKIFEAAKVP----IEWEEVDVTAVRGPDGKFGIPQKAIDSVN 356
+ +I G GIG ++ A QK+ +AA I W V +P+ + ++
Sbjct: 76 IPIIHGDGIGTDVGPAAQKVLDAAAEATGRSIAWMRVYAGGSARDMYDENLPEDTVSAIR 135
Query: 357 ANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN---VDVVTIR 527
+++ +KGPL TPVG G+RSLN+ALRK DLYANVRP L+G+ + N +D++T R
Sbjct: 136 DHRVAIKGPLTTPVGAGFRSLNVALRKTLDLYANVRPTYYLDGVPSPVKNPEKMDMITFR 195
Query: 528 ENTEGEYSGIEHE----------------------IVDGVVQ-SIKLITEEASTRVAEFA 638
ENTE Y+GIE E I DG V +K I+E S R+ A
Sbjct: 196 ENTEDVYAGIEWEAGTDEVEQVRDFLEDDMEIADVIHDGPVGIGVKPISEFGSKRLIREA 255
Query: 639 FQFARENKRKKVTAVHKANIMRMSDGLFLRCCRELATKYPGHQV 770
+A N R VT VHK NIM+ ++G F E+A + G V
Sbjct: 256 IDYALANDRDSVTLVHKGNIMKFTEGAFRDWGYEVAEEEYGDDV 299
>UniRef50_Q5HNL1 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=73; cellular organisms|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Staphylococcus epidermidis (strain ATCC 35984 /
RP62A)
Length = 422
Score = 113 bits (272), Expect = 6e-24
Identities = 77/227 (33%), Positives = 121/227 (53%), Gaps = 33/227 (14%)
Frame = +3
Query: 189 VTLIPGHGIGPEITVAVQKIFEAA-------KVPIEWEEVDVTAVRGPDGKFGIPQKAID 347
+ I G GIGP+I A ++ +AA + IEW+EV + +PQ+ ++
Sbjct: 21 IPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAYDETGEWLPQETLE 80
Query: 348 SVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY---DNVDVV 518
++ I +KGPL TP+G G RSLN+ALR+E DL+ +RP + +G+ + ++VD+V
Sbjct: 81 TIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPEDVDMV 140
Query: 519 TIRENTEGEYSGIE--------HEIVD------GVVQ---------SIKLITEEASTRVA 629
RENTE Y+GIE +++D G IK +++E + R+
Sbjct: 141 IFRENTEDIYAGIEFKQGTSEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLV 200
Query: 630 EFAFQFARENKRKKVTAVHKANIMRMSDGLFLRCCRELATKYPGHQV 770
A Q+A +N RK VT VHK NIM+ ++G F + +LA G +V
Sbjct: 201 RAAIQYALDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLAHNEFGDKV 247
>UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH).; n=1;
Bos taurus|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH). - Bos Taurus
Length = 260
Score = 113 bits (271), Expect = 8e-24
Identities = 51/105 (48%), Positives = 76/105 (72%)
Frame = +3
Query: 444 DLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTR 623
DL ANV +S ++T + N+D++ +R+NTEGEYS +E E ++ VV+S++ +T+ R
Sbjct: 17 DLCANVVQFESQPRVETRHKNIDILVVRDNTEGEYSNLEDESMNRVVESLRTVTKAKCLR 76
Query: 624 VAEFAFQFARENKRKKVTAVHKANIMRMSDGLFLRCCRELATKYP 758
+AE+AFQ A KKVTA +KANIMR+ D LF++CCRE+A+ YP
Sbjct: 77 LAEYAFQLAHRMGCKKVTATYKANIMRLGDCLFIQCCREVASHYP 121
>UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421,
highly similar to PROTEIN KINASE C-BINDING PROTEIN
NELL1; n=2; Homo sapiens|Rep: CDNA FLJ36019 fis, clone
TESTI2016421, highly similar to PROTEIN KINASE C-BINDING
PROTEIN NELL1 - Homo sapiens (Human)
Length = 355
Score = 112 bits (270), Expect = 1e-23
Identities = 51/102 (50%), Positives = 73/102 (71%)
Frame = +3
Query: 429 LRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITE 608
L DLYA+V K+L ++T + +VD++ + ENTEGEYS +EHE V GV +S+K++T+
Sbjct: 2 LHTTLDLYASVIHLKNLPNVETWHKDVDILVVWENTEGEYSNLEHESVKGVTESLKIMTK 61
Query: 609 EASTRVAEFAFQFARENKRKKVTAVHKANIMRMSDGLFLRCC 734
S R+AE+AFQ A++ KKV AVHK NI ++ DG FL+CC
Sbjct: 62 AKSLRIAEYAFQLAQKMGCKKVMAVHKVNITKLGDGPFLQCC 103
>UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;
n=1; Ignicoccus hospitalis KIN4/I|Rep: 3-isopropylmalate
dehydrogenase - Ignicoccus hospitalis KIN4/I
Length = 343
Score = 110 bits (265), Expect = 4e-23
Identities = 73/196 (37%), Positives = 114/196 (58%), Gaps = 11/196 (5%)
Frame = +3
Query: 189 VTLIPGHGIGPEITVA----VQKIFEAAKVPIEWEEVDVTAVRGPDGKFG--IPQKAIDS 350
V +I G GIGPE+ A ++KI E K+P+E+ V V A K+G +P+++ +
Sbjct: 4 VAVIEGDGIGPEVVGATLKVLEKIRETFKLPLEF--VFVEAGDRAKEKYGEALPKESYER 61
Query: 351 VNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRE 530
+ LKGP VG+ + + LR+E DL+AN+RP K L G+ L +NVD++ +RE
Sbjct: 62 LLRADAILKGP----VGETAADVIVRLRRELDLFANIRPAKVLPGVPALKENVDLIIVRE 117
Query: 531 NTEGEYSGIEH-----EIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKAN 695
N E Y G E+ + V ++L +E + RVA+ A ++A+ +R KVT VHKAN
Sbjct: 118 NIEDLYVGAENLLPQTSLGHKVAVGLRLASERETRRVAKVAAEYAKA-RRNKVTIVHKAN 176
Query: 696 IMRMSDGLFLRCCREL 743
+MR++ GLF +E+
Sbjct: 177 VMRVTCGLFRDVAKEV 192
>UniRef50_O29610 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=15; Archaea|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Archaeoglobus fulgidus
Length = 412
Score = 110 bits (265), Expect = 4e-23
Identities = 83/230 (36%), Positives = 117/230 (50%), Gaps = 33/230 (14%)
Frame = +3
Query: 132 KIVPATRAGAAQYSTG---VRKVTLIP---GHGIGPEITVAVQKIFEAAKVPIEWEEVDV 293
K+ P +Y G V +IP G GIG ++ A ++ +AA I E V
Sbjct: 5 KVKPPENGEKIRYENGKLIVPDNPIIPYFEGDGIGKDVVPAAIRVLDAAADKIGKEVVWF 64
Query: 294 TAVRGPDGK--FG--IPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANV 461
G D +G +P ++++ ++ LKGPL TPVG GYRSLN+ +R+ DLYANV
Sbjct: 65 QVYAGEDAYKLYGNYLPDDTLNAIKEFRVALKGPLTTPVGGGYRSLNVTIRQVLDLYANV 124
Query: 462 RPCKSLEGIKTLY---DNVDVVTIRENTEGEYSGIE-----HEIVD---------GVV-- 584
RP L+G+ + + V+ V RENTE Y+GIE E + GV
Sbjct: 125 RPVYYLKGVPSPIKHPEKVNFVIFRENTEDVYAGIEWPRGSEEALKLIRFLKNEFGVTIR 184
Query: 585 ----QSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSDGLF 722
IK I+E A+ R+ A ++A EN RK VT VHK NIM+ ++G F
Sbjct: 185 EDSGIGIKPISEFATKRLVRMAIRYAIENNRKSVTLVHKGNIMKYTEGAF 234
>UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8; n=1; Pan
troglodytes|Rep: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8 - Pan troglodytes
Length = 331
Score = 109 bits (262), Expect = 9e-23
Identities = 56/135 (41%), Positives = 90/135 (66%), Gaps = 2/135 (1%)
Frame = +3
Query: 189 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKI 368
VT++PG G+GPE+ AV+++F+AA VP+E++E ++ V+ + + Q + S+ NK+
Sbjct: 51 VTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQ-VLSSMKENKV 109
Query: 369 GLKGPLMTPVG-KG-YRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEG 542
+ G + TP+ KG S ++ LR++ DL+ANV KSL G T ++N+D+V IRE TEG
Sbjct: 110 AIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEG 169
Query: 543 EYSGIEHEIVDGVVQ 587
EYS +EHE + V +
Sbjct: 170 EYSSLEHECCEEVAE 184
>UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for
NADP+; n=3; Alteromonadales|Rep: Isocitrate
dehydrogenase, specific for NADP+ - Alteromonadales
bacterium TW-7
Length = 422
Score = 107 bits (257), Expect = 4e-22
Identities = 77/223 (34%), Positives = 115/223 (51%), Gaps = 35/223 (15%)
Frame = +3
Query: 189 VTLIPGHGIGPEITVAVQKIFEAA-------KVPIEWEEV--DVTAVRGPDGKFGIPQKA 341
+ I G G+G ++ ++ I + A K I W +V A + DG + PQ+
Sbjct: 31 IAYINGDGVGQDVMPVMRNIVDCAIKHCYKNKRKIHWMQVFNGEQAAKLYDGDW-FPQET 89
Query: 342 IDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN---VD 512
I +V A KI +KGPL TP+G G+RSLN+ALR+E DL+ N+R K + + N +
Sbjct: 90 IQAVRACKIAIKGPLTTPLGGGFRSLNVALRQEMDLFVNMRTIKGFSALPSPLKNPFLTN 149
Query: 513 VVTIRENTEGEYSGIE--------HEIVD------GVVQ---------SIKLITEEASTR 623
+ +R+++E YSGIE +++D GV + IK I++E S R
Sbjct: 150 ITVLRDSSEDVYSGIEWQAGSIESEKMLDFLCEEMGVTRLRFSQDCGIGIKNISKEGSER 209
Query: 624 VAEFAFQFARENKRKKVTAVHKANIMRMSDGLFLRCCRELATK 752
+ FA FA N R VT VHK N+++ +DG F R LA K
Sbjct: 210 LTRFALNFALNNNRDSVTFVHKGNVLKFTDGAFKRWGFALAKK 252
>UniRef50_Q6L2P9 Cluster: Isocitrate dehydrogenase [NADP]; n=2;
Thermoplasmatales|Rep: Isocitrate dehydrogenase [NADP] -
Picrophilus torridus
Length = 392
Score = 106 bits (254), Expect = 9e-22
Identities = 70/209 (33%), Positives = 111/209 (53%), Gaps = 28/209 (13%)
Frame = +3
Query: 204 GHGIGPEITVAVQKIFEAA----KVPIEWEEVDVTAVRGPDGKFG-IPQKAIDSVNANKI 368
G GIGPEI A +K+ +AA K I W+E+ + R + K P+++I ++N ++
Sbjct: 24 GDGIGPEIMDATRKVVDAATAMEKKSIAWKEI-LLGDRAEELKGDRFPEESIKAINDYRV 82
Query: 369 GLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN---VDVVTIRENTE 539
LK PL TPVGKG++S+N+ +R DLYAN+RP K + G+++ N V++ RENT+
Sbjct: 83 LLKAPLNTPVGKGFKSINVRIRMLLDLYANIRPVKFMPGLESPLKNPEKVNLTIFRENTD 142
Query: 540 GEYSGIEH--------------------EIVDGVVQSIKLITEEASTRVAEFAFQFAREN 659
Y G E +I D IK ++ + R+ A ++A +N
Sbjct: 143 DLYLGYEWSYDTDEAKRIRKFLKDEFNIDISDDSGIGIKPMSRYKTQRITRLAVKYAMDN 202
Query: 660 KRKKVTAVHKANIMRMSDGLFLRCCRELA 746
KK+T +HK N+M+ ++G F E A
Sbjct: 203 NLKKITIMHKGNVMKYTEGAFREWAYETA 231
>UniRef50_Q58991 Cluster: Threo-isocitrate dehydrogenase [NAD]; n=9;
Methanococcales|Rep: Threo-isocitrate dehydrogenase
[NAD] - Methanococcus jannaschii
Length = 347
Score = 105 bits (253), Expect = 1e-21
Identities = 79/211 (37%), Positives = 114/211 (54%), Gaps = 21/211 (9%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDG-----KFG--IPQKAI 344
KV +I G GIG E+ I EA K+ E E ++ ++G G K+G +P+ I
Sbjct: 3 KVCVIEGDGIGKEV------IPEAIKILNELGEFEI--IKGEAGLECLKKYGNALPEDTI 54
Query: 345 DSVNANKIGLKGPLMTPVG---KGYRSLNLALRKEFDLYANVRPCKSLEGIKTL------ 497
+ I L G + +P + Y+S + LRK F LYANVRP + GI L
Sbjct: 55 EKAKEADIILFGAITSPKPGEVQNYKSPIITLRKMFHLYANVRPINNF-GIGQLIGKIAD 113
Query: 498 YD-----NVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENK 662
Y+ N+D+V IRENTE Y G E D + ++IT + S R+ FAF++A +N
Sbjct: 114 YEFLNAKNIDIVIIRENTEDLYVGRERLENDTAIAE-RVITRKGSERIIRFAFEYAIKNN 172
Query: 663 RKKVTAVHKANIMRMSDGLFLRCCRELATKY 755
RKKV+ +HKAN++R++DGLFL E+ Y
Sbjct: 173 RKKVSCIHKANVLRITDGLFLEVFNEIKKHY 203
>UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Methanosaeta thermophila PT|Rep: Isocitrate
dehydrogenase (NAD(+)) - Methanosaeta thermophila
(strain DSM 6194 / PT) (Methanothrixthermophila (strain
DSM 6194 / PT))
Length = 375
Score = 104 bits (250), Expect = 3e-21
Identities = 68/201 (33%), Positives = 104/201 (51%), Gaps = 14/201 (6%)
Frame = +3
Query: 198 IPGHGIGPEIT-VAVQKIFEAAKVPIEWEEVDVTAVRGPD------GKFGIPQKAIDSVN 356
+ G GIGP IT A++ + + +E +V+ + G +P A+D++
Sbjct: 21 VDGDGIGPYITGEAIRVLQSLLRDELERGDVEFRKIEGLSIEERARAMKALPDDALDALK 80
Query: 357 ANKIGLKGPLMTPVGKG-----YRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVT 521
+ LKGPL TP KG S N+A+R+E DL+ANVRP + + +D V
Sbjct: 81 KCHVILKGPLTTPK-KGDPWPNLESANVAMRRELDLFANVRP------VSIPSEGIDWVF 133
Query: 522 IRENTEGEY--SGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKAN 695
RENTEGEY + D + K+IT + S R+ AF +AR N +V+ V KAN
Sbjct: 134 FRENTEGEYVLGSKGFNVTDDLAVDFKVITTQGSERIIRLAFDYARRNNINRVSVVTKAN 193
Query: 696 IMRMSDGLFLRCCRELATKYP 758
+++ +DG FL R ++ +YP
Sbjct: 194 VVKTTDGKFLEIARAISKEYP 214
>UniRef50_Q9RTT2 Cluster: Isocitrate dehydrogenase, putative; n=2;
Deinococcus|Rep: Isocitrate dehydrogenase, putative -
Deinococcus radiodurans
Length = 333
Score = 104 bits (249), Expect = 4e-21
Identities = 62/183 (33%), Positives = 100/183 (54%), Gaps = 3/183 (1%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 365
++ LI G GIG E+ A +++ EAA E+ + D +P+ D+V
Sbjct: 5 RICLIEGDGIGHEVIPAAKRVLEAAGFDAEYVHAEAGYEYFLDHGTSVPEATYDAVENTD 64
Query: 366 IGLKGPLMTPVGK---GYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENT 536
L G +P G+ G+ LR++++LYANVRP K+ + Y+NVD+V +RENT
Sbjct: 65 ATLFGAATSPSGEKPAGFFGAIRHLRQKYNLYANVRPTKT-RPVPHSYENVDLVIVRENT 123
Query: 537 EGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSDG 716
+G Y E D + +IT EAS R+ +FA A + + K++T VHK+N++ ++ G
Sbjct: 124 QGLYVEQERRYGDTAIAD-TVITREASDRIGKFAADLAMK-RSKRLTVVHKSNVLPVTQG 181
Query: 717 LFL 725
LF+
Sbjct: 182 LFM 184
>UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodococcus sp. (strain RHA1)
Length = 365
Score = 101 bits (241), Expect = 3e-20
Identities = 67/208 (32%), Positives = 109/208 (52%), Gaps = 17/208 (8%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAAKVP-----IEWEEVDVTAVRGPDGKFGIPQKAIDS 350
++ ++ G GIG EI A Q++ AA V ++W E+ + IP + +
Sbjct: 12 RIGVLLGDGIGHEIVPATQRVVSAAVVAAGGGAVDWVELPLGLGAIESHGTPIPDSTLSA 71
Query: 351 VNANKIGLKGPLMTPVG----KGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVV 518
++A + GP + +G + +RK FDL+AN+RP +SLEG+ + ++D+V
Sbjct: 72 LDALDAWILGPHDSAAYPEPFRGRLTPGGVVRKRFDLFANIRPARSLEGVASTVPDMDLV 131
Query: 519 TIRENTEGEYS-------GIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVT 677
+RENTEG Y+ E V ++ ++T +A R+A AF AR + + VT
Sbjct: 132 IVRENTEGLYADRNMFAGSGEFMPTPDVALAVGVVTRKACERIAHTAFALAR-TRGRHVT 190
Query: 678 AVHKANIMRMSDGLFLRCCRELATK-YP 758
VHKAN++ M+ GLF CRE+ + YP
Sbjct: 191 IVHKANVLSMTTGLFRDVCREVGQRDYP 218
>UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Proteobacteria|Rep: 3-isopropylmalate dehydrogenase -
Bradyrhizobium japonicum
Length = 365
Score = 99.5 bits (237), Expect = 1e-19
Identities = 74/221 (33%), Positives = 111/221 (50%), Gaps = 15/221 (6%)
Frame = +3
Query: 153 AGAAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWE-EVDVTAVRGPDGK-FG 326
A A Q+ V ++ ++PG GIGPEIT A + AA + ++ AV K FG
Sbjct: 3 APALQFWGNVMQLIVLPGDGIGPEITTATSGVLRAASERFQLNLRLEEHAVGHASLKQFG 62
Query: 327 --IPQKAIDSVNANKIGLKGPLMTPVGK--GYRSLNLA--LRKEFDLYANVRPCKSLEGI 488
+ + +D V + GP T K + +N + RK DLYANVRP ++ G
Sbjct: 63 TTVRPELLDIVRGADGLILGPTATFDFKDEAHGEINPSRHFRKNLDLYANVRPARTYAGR 122
Query: 489 KTLYDNVDVVTIRENTEGEYSGIEHE-------IVDGVVQSIKLITEEASTRVAEFAFQF 647
+ D+V +RENTEG Y+ E + V S++ IT R+A A +
Sbjct: 123 PGRLGDFDLVVVRENTEGFYADRNMEQGNGEMLVTPDVAISLRRITRACCERIAHAACRL 182
Query: 648 ARENKRKKVTAVHKANIMRMSDGLFLRCCRELATKYPGHQV 770
A + +R+ +T VHKAN++++ DG+FL CR A Y G +V
Sbjct: 183 AMK-RRRHLTIVHKANVLKIGDGMFLDICRAAAKGYAGLEV 222
>UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2;
Alphaproteobacteria|Rep: Isopropylmalate dehydrogenase -
Oceanicola granulosus HTCC2516
Length = 363
Score = 99.5 bits (237), Expect = 1e-19
Identities = 71/218 (32%), Positives = 112/218 (51%), Gaps = 19/218 (8%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAAK----VPIEWEEVDVTAVRGPDGKFGIPQKAIDSV 353
K+ ++ G IG EI A ++ AA + I+W +V + A +P+ ++++
Sbjct: 7 KLGILNGDDIGHEIVPASVEVARAAAGKAGLGIDWTDVPIGAAALESHGHTMPEGTMETL 66
Query: 354 NANKIGLKGPLMTPVG-KGYRSLNLA------LRKEFDLYANVRPCKSLEGIKTLYDNVD 512
GL G ++ P+G + Y + A LRK FDL+ANVRP +S GI L+D++D
Sbjct: 67 E----GLDGWILGPIGHRDYPKVPGAINPHPILRKGFDLFANVRPTRSYPGIGCLFDDID 122
Query: 513 VVTIRENTEG--------EYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRK 668
+V +REN EG SG E + V S+++IT E +V A AR RK
Sbjct: 123 LVIVRENNEGFQPDRNVVAGSG-EFRPTEDVTISVRVITVEGCRKVVRAALDIARSRPRK 181
Query: 669 KVTAVHKANIMRMSDGLFLRCCRELATKYPGHQVRRAI 782
K+T VHK + ++ G+F+ E+A +YP +V I
Sbjct: 182 KLTLVHKNTVFKLGCGMFVDTAYEVAKEYPDVEVDECI 219
>UniRef50_Q0W1Q6 Cluster: 2-isopropylmalate dehydrogenase; n=5;
Euryarchaeota|Rep: 2-isopropylmalate dehydrogenase -
Uncultured methanogenic archaeon RC-I
Length = 324
Score = 99.5 bits (237), Expect = 1e-19
Identities = 65/187 (34%), Positives = 100/187 (53%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 365
K+ ++PG GIG E+ ++ + A E+ V+V R + +++V A
Sbjct: 2 KIAVLPGDGIGREVVPVAHEVLKVALPDAEFLHVEVGNERYVREGVSMSPADLETVKACD 61
Query: 366 IGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGE 545
L G + +P GK YRS+ L LRKE DLYAN+RP +S V+ REN+E
Sbjct: 62 CVLFGAITSPPGKPYRSIILTLRKELDLYANIRPFRS---CPISPRKVNFTIYRENSEDL 118
Query: 546 YSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSDGLFL 725
Y GIE EI +S+++IT +AS R+A A + K+T VHK+N+++ +D LF
Sbjct: 119 YMGIE-EITGDEARSVRVITRKASERIARAA---CSKPGIGKLTIVHKSNVLK-ADELFK 173
Query: 726 RCCRELA 746
C ++A
Sbjct: 174 DACAQVA 180
>UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep: Isocitrate
dehydrogenase (NAD(+)) - Candidatus Nitrosopumilus
maritimus SCM1
Length = 343
Score = 98.7 bits (235), Expect = 2e-19
Identities = 60/185 (32%), Positives = 98/185 (52%), Gaps = 5/185 (2%)
Frame = +3
Query: 183 RKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVR----GPDGKFGIPQKAIDS 350
+K ++ G GIGPE+ ++ ++ + E + + + G IP +
Sbjct: 3 KKAAVMKGDGIGPEVVDSMLRVLKECNFQSELILCEAGSEQWDKNGRKDASYIPDVTMKI 62
Query: 351 VNANKIGLKGPLMT-PVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIR 527
+ KGP T PV RS+ + LR++FDLYAN+RP K+ + + T +D V R
Sbjct: 63 LEETDCCFKGPTTTIPVPGAPRSVAVTLRQKFDLYANIRPTKTYDRL-TPDRKLDCVCFR 121
Query: 528 ENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRM 707
E TEG Y+G+E +I D +I+ IT + S R+ + A +A + KK+ AV K NI++
Sbjct: 122 EATEGLYTGVEAKITDDAAIAIRKITRQGSRRLIDSAVDWANKFNMKKMVAVTKRNILKQ 181
Query: 708 SDGLF 722
+DG+F
Sbjct: 182 TDGIF 186
>UniRef50_O67480 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=3; Aquificaceae|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Aquifex aeolicus
Length = 426
Score = 98.7 bits (235), Expect = 2e-19
Identities = 83/242 (34%), Positives = 123/242 (50%), Gaps = 40/242 (16%)
Frame = +3
Query: 189 VTLIPGHGIGPEIT--------VAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFG--IPQK 338
+ I G GIGPEIT AV+K + +K I W V++ A + K G +PQ+
Sbjct: 41 IPFIEGDGIGPEITQAMLLIINTAVEKTYNGSK-KIYW--VELLAGDKAEEKTGERLPQE 97
Query: 339 AIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN---V 509
+D + + +G+KGPL TPVGKG RS+N ALR+ FD Y+ VRP + G T N V
Sbjct: 98 TLDVLKESIVGIKGPLGTPVGKGVRSINSALRRAFDYYSAVRPVYWM-GQATPIPNPERV 156
Query: 510 DVVTIRENTEGEYSGIE-----------HEIV------------DGVVQSIKLITEEAST 620
D+V RENT+ Y+G+E E + + V ++K ++E +
Sbjct: 157 DLVVFRENTDDVYAGVEFFAGTPEAKKVREFLIKEMGAKEEGFPEDVGITVKPMSEFKTK 216
Query: 621 RVAEFAFQFARENKRKKVTAVHKANIMRMSDGLFLRCCRELA--TKYPGHQVR--RAIPG 788
R A ++A EN +K V + K NIM+ ++G F+ E+A ++ G V A PG
Sbjct: 217 RHVRKALRYALENNKKNVAVIGKGNIMKATEGAFINWAFEVAEEPEFKGKVVTDPEAEPG 276
Query: 789 HG 794
G
Sbjct: 277 EG 278
>UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Thermoproteaceae|Rep: 3-isopropylmalate dehydrogenase -
Pyrobaculum aerophilum
Length = 290
Score = 96.3 bits (229), Expect = 9e-19
Identities = 53/137 (38%), Positives = 87/137 (63%), Gaps = 2/137 (1%)
Frame = +3
Query: 318 KFG--IPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIK 491
K+G +PQ+A+ +A + KGP +G+ + +R + LYAN+RP K+L G+
Sbjct: 15 KYGTAMPQEALRLADAADVIFKGP----IGESAYDVTSLIRMRYTLYANIRPVKNLPGVP 70
Query: 492 TLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKK 671
+ + +D V +REN E Y G E+++ D V ++K+ITE+ + RVA A ++A E +R++
Sbjct: 71 AVRE-IDCVFVRENVEDVYVGAEYKVGD-VAIALKVITEKGTRRVARMARKYA-EMRRRR 127
Query: 672 VTAVHKANIMRMSDGLF 722
VT VHKAN++R+ DG F
Sbjct: 128 VTIVHKANVLRVVDGFF 144
>UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Chloroflexi (class)|Rep: 3-isopropylmalate dehydrogenase
- Roseiflexus sp. RS-1
Length = 362
Score = 95.5 bits (227), Expect = 2e-18
Identities = 69/209 (33%), Positives = 97/209 (46%), Gaps = 15/209 (7%)
Frame = +3
Query: 189 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKI 368
+ +IPG GIG E+ A + A +P +E D +P + + A
Sbjct: 8 ILVIPGDGIGREVIPAAVAVLRATGLPFHFENADAGWECFQRQGEALPSATLTAARAADA 67
Query: 369 GLKGPLMTP--VGKGYRSLNLALRKEFDLYANVRPCKS---LEGIKTLYDNVDVVTIREN 533
L G + +P GYRS + LR+E DLYAN+RP G VD+V +REN
Sbjct: 68 ILFGAVASPGYPVAGYRSPIVRLRRELDLYANIRPVFDDLPENGSNPRRRKVDLVVVREN 127
Query: 534 TEGEYSGIEHEIVDGVVQ-SIKLITEEASTRVAEFAFQFARENKRKK---------VTAV 683
TE Y+G E DG + ++IT AS R+ A AR + + VT V
Sbjct: 128 TEDVYAGRERVEDDGATAIAERVITRRASARIMRVACDLARARRSARNGSDAPPGRVTVV 187
Query: 684 HKANIMRMSDGLFLRCCRELATKYPGHQV 770
HKAN++R + GLF E+A YP Q+
Sbjct: 188 HKANVLRETCGLFRSVALEVAQAYPDLQI 216
>UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase,
mitochondrial precursor; n=33; Dikarya|Rep:
Homoisocitrate dehydrogenase, mitochondrial precursor -
Saccharomyces cerevisiae (Baker's yeast)
Length = 371
Score = 94.7 bits (225), Expect = 3e-18
Identities = 77/222 (34%), Positives = 115/222 (51%), Gaps = 22/222 (9%)
Frame = +3
Query: 144 ATRAGAAQ--YSTGVRK---VTLIPGHGIGPEITVAVQKIFE--AAKVPIEWEEVDVTA- 299
ATR A + S RK + LIPG GIG E+ A +++ E +K + + +D+ A
Sbjct: 6 ATRLSACRGLASNAARKSLTIGLIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFIDLYAG 65
Query: 300 --VRGPDGKFGIPQKAIDSVNANKIG-LKGPLMTPVGK--GYRSLNLALRKEFDLYANVR 464
GK +P + + + G L G + +P K GY S +ALR+E L+ANVR
Sbjct: 66 FQTFQETGK-ALPDETVKVLKEQCQGALFGAVQSPTTKVEGYSSPIVALRREMGLFANVR 124
Query: 465 PCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVD-----GVVQSIKLITEEASTRVA 629
P KS+EG K +D+V +RENTE Y IE +D V + K I+E A+ R+A
Sbjct: 125 PVKSVEGEKG--KPIDMVIVRENTEDLYIKIEKTYIDKATGTRVADATKRISEIATRRIA 182
Query: 630 EFAFQFARENKRKK----VTAVHKANIMRMSDGLFLRCCREL 743
A A + + + +T HK+N++ SDGLF C+E+
Sbjct: 183 TIALDIALKRLQTRGQATLTVTHKSNVLSQSDGLFREICKEV 224
>UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=504; root|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Helicobacter pylori (Campylobacter pylori)
Length = 425
Score = 93.9 bits (223), Expect = 5e-18
Identities = 74/236 (31%), Positives = 121/236 (51%), Gaps = 42/236 (17%)
Frame = +3
Query: 189 VTLIPGHGIGPEITVAVQKIFEAA-------KVPIEWEEVDVTAV----------RGPDG 317
+ I G GIG +IT A+ K+ ++A + I W EV V P+
Sbjct: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQKFKDYKELSPEE 91
Query: 318 KFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTL 497
++ +P I+++N K+ +KGPL TP+G+G+RSLN+ALR++ DLY +RP + +
Sbjct: 92 QWLLPD-TIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQKMDLYVCLRPVRWYGSPSPV 150
Query: 498 YD--NVDVVTIRENTEGEYSGIE----------------HEIVDGVVQ-------SIKLI 602
+ VD+V REN+E Y+GIE +E+ ++ +K I
Sbjct: 151 KEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVKKIRFPESSGIGVKPI 210
Query: 603 TEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSDGLFLRCCRELATKYPGHQV 770
++E + R+ A ++A +N + VT VHK NIM+ ++G F++ LA K QV
Sbjct: 211 SKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQKEFNAQV 266
>UniRef50_Q9CKK6 Cluster: Idp; n=2; Pasteurellaceae|Rep: Idp -
Pasteurella multocida
Length = 415
Score = 92.3 bits (219), Expect = 2e-17
Identities = 67/226 (29%), Positives = 115/226 (50%), Gaps = 37/226 (16%)
Frame = +3
Query: 189 VTLIPGHGIGPEITVAVQKIFEAA-------KVPIEWEEV----DVTAVRGPDGKFGIPQ 335
+ I G GIG ++T A++ + +AA K I W E+ V G + +P
Sbjct: 29 IPFIEGDGIGVDVTPAMRTVIDAAVEKAYGGKRKISWMEIYAGGKANEVYGENT--WLPD 86
Query: 336 KAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN--- 506
+ + + + +KGPLMTPVG G RSLN+A+R+ DLY +RP + +G + +
Sbjct: 87 ETMTFIRDYHVAIKGPLMTPVGGGIRSLNVAMRQGLDLYNCLRPIRYYDGTPSPVKHPEL 146
Query: 507 VDVVTIRENTEGEYSGIE--------HEIVDGVVQ---------------SIKLITEEAS 617
VD+V REN+E Y+G+E ++++ + Q IK ++++ +
Sbjct: 147 VDMVIFRENSEDIYAGVEWVAGSAEANKVIAFLQQEMGVKKIRFTEDCGIGIKPVSKQGT 206
Query: 618 TRVAEFAFQFARENKRKKVTAVHKANIMRMSDGLFLRCCRELATKY 755
R+ A Q+ +N RK +T VHK NIM+ ++G F ++A ++
Sbjct: 207 QRLVRAALQYVIDNDRKSLTLVHKGNIMKFTEGAFKEWGYQVAQEF 252
>UniRef50_Q8FPV5 Cluster: 3-isopropylmalate dehydrogenase; n=50;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Corynebacterium efficiens
Length = 340
Score = 90.2 bits (214), Expect = 6e-17
Identities = 66/204 (32%), Positives = 103/204 (50%), Gaps = 13/204 (6%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRG-PDGKFGIPQ-----KAID 347
K+ +I G GIGPE+T K+ A + IE ++D+ A R +G+ + + D
Sbjct: 2 KLAVIGGDGIGPEVTDEALKVLRALRADIETTDLDLGARRYLRNGELLTDEDLALLREHD 61
Query: 348 SVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN---VDVV 518
++ IG G + P G R L L LR D + N+RP K EG+++ N +D V
Sbjct: 62 AILLGAIGAPGSV--PPGVLERGLLLKLRFALDHHVNLRPSKLYEGVESPLKNPGEIDFV 119
Query: 519 TIRENTEGEYSGIEHEIVDG----VVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVH 686
+RE TEG Y+G I G + T + RV +AF+ A +++R+ +T VH
Sbjct: 120 VVREGTEGAYTGNGGAIRVGTPHETANETSVNTRYGAERVIRYAFELA-QSRRRHLTLVH 178
Query: 687 KANIMRMSDGLFLRCCRELATKYP 758
K N++ GL+ R E+A +YP
Sbjct: 179 KTNVLVHGGGLWQRTVDEVAREYP 202
>UniRef50_A1SM34 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Nocardioides sp. JS614|Rep: 3-isopropylmalate
dehydrogenase - Nocardioides sp. (strain BAA-499 /
JS614)
Length = 478
Score = 88.6 bits (210), Expect = 2e-16
Identities = 65/213 (30%), Positives = 100/213 (46%), Gaps = 17/213 (7%)
Frame = +3
Query: 171 STGVRKVTLIPGHGIGPEITVAVQKIFEAAK---VPIEWEEVDVTAVRGPDGKFGIPQKA 341
++G ++ +IPG GIGPE+T K+ E A V E D+ A R +P
Sbjct: 128 TSGSLRLAVIPGDGIGPEVTAEALKVLEVASPAGVKFEQTRYDLGAERYLATGEVLPDSV 187
Query: 342 IDSVNANKIGLKGPL-------MTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY 500
++ + + L G + P G R L L LR E D Y N+RP + G+ +
Sbjct: 188 LEEIREHDAILLGAVGGKPNDPNLPPGILERGLLLRLRFELDHYVNLRPSRIFPGVASPL 247
Query: 501 DN---VDVVTIRENTEGEYSGIEHEIVDG----VVQSIKLITEEASTRVAEFAFQFAREN 659
N VD V +RE TEG Y+G + G + + + T RV AF A+
Sbjct: 248 ANPGEVDFVVVREGTEGPYTGNGGALRVGTPHEIATEVSVNTAFGVERVVRDAFARAQRR 307
Query: 660 KRKKVTAVHKANIMRMSDGLFLRCCRELATKYP 758
RKK+T VHK N++ + ++ R +++A +YP
Sbjct: 308 PRKKLTLVHKTNVLVNAGAVWWRITQQVAAEYP 340
>UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;
n=4; cellular organisms|Rep: LeuB-1 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 354
Score = 86.2 bits (204), Expect = 1e-15
Identities = 65/204 (31%), Positives = 100/204 (49%), Gaps = 14/204 (6%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITV----AVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSV 353
++ +IPG GIG E+ ++K+ E ++V E++E A +P AI+
Sbjct: 4 RIAVIPGDGIGKEVVAEGLKVLKKLEELSRVSFEFKEYPFGAEHYLKTGETLPDWAIEEF 63
Query: 354 ---NANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY---DNVDV 515
+A G G G R + L +R E DLY N+RP K T + +D+
Sbjct: 64 KKFDAIYFGAIGDPRVKPGILERGILLKMRFELDLYVNLRPVKLYHPRLTPLKGKNKIDI 123
Query: 516 VTIRENTEGEYSGIEHEIVDGVVQSIK----LITEEASTRVAEFAFQFARENKRKKVTAV 683
V +RENTEG Y+G + G Q I + T RV FAF++A+ + RKKVT V
Sbjct: 124 VFVRENTEGLYAGAGGFLRKGTPQEIAVQEMINTRFGVERVIRFAFEYAKRSGRKKVTLV 183
Query: 684 HKANIMRMSDGLFLRCCRELATKY 755
KAN++ + L+ R E++ +Y
Sbjct: 184 DKANVLTYAHDLWERVFAEVSQEY 207
>UniRef50_Q8XSY8 Cluster: Probable 3-isopropylmalate dehydrogenase
oxidoreductase protein; n=1; Ralstonia solanacearum|Rep:
Probable 3-isopropylmalate dehydrogenase oxidoreductase
protein - Ralstonia solanacearum (Pseudomonas
solanacearum)
Length = 365
Score = 85.8 bits (203), Expect = 1e-15
Identities = 67/210 (31%), Positives = 108/210 (51%), Gaps = 19/210 (9%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAAK------VPIEWEEVDVTAVR--GPDGKFGIPQKA 341
++ ++P GIGPEI A ++ +A + ++++V T++ G + + KA
Sbjct: 2 RILVLPCDGIGPEIVGAAMEVLRSADSVFKLDLAFDYDDVGFTSLEKYGTTLRDEVLAKA 61
Query: 342 IDSVNANKIGLKGPLMTPV-GKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN---V 509
+ + +G + P KG R+++ R DLYANVRP ++ + + +
Sbjct: 62 -KTYDGVILGTQSHADYPAPDKGGRNVSAGFRIGLDLYANVRPARTRPFLTSNMREGRTM 120
Query: 510 DVVTIRENTEGEYSGIEH-----EIVDGVVQSIKL--ITEEASTRVAEFAFQFARENKRK 668
D+V +RE TEG Y E++ +I L IT S R+A AF+ A + K K
Sbjct: 121 DLVIMREATEGFYPDRNMTKGWAELMPSPDMAISLRKITRHCSERIARRAFELAMKRK-K 179
Query: 669 KVTAVHKANIMRMSDGLFLRCCRELATKYP 758
KVTA+HKAN M+DGLFL C R++A +P
Sbjct: 180 KVTAIHKANSFHMTDGLFLECVRDVARDFP 209
>UniRef50_A7T3D9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 419
Score = 85.4 bits (202), Expect = 2e-15
Identities = 57/162 (35%), Positives = 85/162 (52%), Gaps = 13/162 (8%)
Frame = +3
Query: 189 VTLIPGHGIGPEITVAVQKIFEAA-------KVPIEWEEVDV--TAVRGPDGKFGIPQKA 341
+ I G GIG +I+ + K+ +AA + I W EV A + D +PQ+
Sbjct: 31 IPFIEGDGIGIDISPVMIKVVDAAVQKAYGGERKISWMEVYAGEKATQVYDQDTWLPQET 90
Query: 342 IDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY---DNVD 512
+D+V + +KGPL TPVG G RSLN+ALR++ DLY +RP + EG+ + +VD
Sbjct: 91 LDAVKDYVVSIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRWFEGVPSPVKKPGDVD 150
Query: 513 VVTIRENTEGEYSGIEHEI-VDGVVQSIKLITEEASTRVAEF 635
+ REN+E Y+GIE + + IK + EE F
Sbjct: 151 MTIFRENSEDIYAGIEWKAGSPEATKVIKFLKEEMGVTKIRF 192
>UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma;
n=1; Danio rerio|Rep: Isocitrate dehydrogenase 3 (NAD+)
gamma - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 289
Score = 85.0 bits (201), Expect = 2e-15
Identities = 55/173 (31%), Positives = 91/173 (52%), Gaps = 3/173 (1%)
Frame = +3
Query: 162 AQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKA 341
A+Y G VTLIPG GIGPE+ V+++F + VP+++E V V + + A
Sbjct: 45 AKYG-GRHTVTLIPGDGIGPELLNHVRELFRFSCVPVDFEVVHVNSSSTSEDDIS---NA 100
Query: 342 IDSVNANKIGLKGPLMT--PVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDV 515
I ++ N + LKG + T + ++S N LR DLYANV C+SL G++T + N+D+
Sbjct: 101 IMAIRRNGVALKGNIETNHTMPPNHKSRNNLLRTSLDLYANVMHCQSLPGVQTRHKNIDI 160
Query: 516 VTIRENTEGEYSGIEHEIVDGVVQSIKL-ITEEASTRVAEFAFQFARENKRKK 671
+ I E +E E+E + + +++ + + + R A+ E R K
Sbjct: 161 IIILEKSEFSALLAENEKIKVELLQLRIQLADVINKRRADIILDLNIEKSRVK 213
>UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;
n=4; Thermococcaceae|Rep: LeuB-2 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 346
Score = 84.6 bits (200), Expect = 3e-15
Identities = 68/202 (33%), Positives = 101/202 (50%), Gaps = 3/202 (1%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 365
+V +I G GIGPE+ + ++ + I + E + + G P D K
Sbjct: 3 RVAVIKGDGIGPEVVDSAIRVVNSVTDRIRFYEFE--GGFEVFKRIGSPISEDDLKEIRK 60
Query: 366 IG--LKGPLMTPVG-KGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENT 536
+ L G TP GYRSL + LRKE DLYAN+R I L + ++V +RENT
Sbjct: 61 MDAILFGATTTPFNVPGYRSLIVTLRKELDLYANLRI------IPDLSNGKEIVIVRENT 114
Query: 537 EGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSDG 716
EG Y+ D + ++IT E + R+A+FA A+E + +T VHKAN+++ D
Sbjct: 115 EGLYARDGIGFSDRAI-DFRIITLEGARRIAKFAINLAKE-RNSFITFVHKANVLK-GDR 171
Query: 717 LFLRCCRELATKYPGHQVRRAI 782
F E+A + G +VR AI
Sbjct: 172 FFREIVLEIAER-EGVEVREAI 192
>UniRef50_A5URE6 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=4; Chloroflexaceae|Rep: Isocitrate dehydrogenase,
NADP-dependent - Roseiflexus sp. RS-1
Length = 453
Score = 81.8 bits (193), Expect = 2e-14
Identities = 48/135 (35%), Positives = 75/135 (55%), Gaps = 10/135 (7%)
Frame = +3
Query: 189 VTLIPGHGIGPEITVAVQKIFEAA-------KVPIEWEEVDVTAVRGPDGKFGIPQKAID 347
+ + G G GP+I A ++F+AA + + W EV +P + ++
Sbjct: 29 IPYVEGDGTGPDIWRASVRVFDAAVERAYGGRRKLMWYEVLAGEKAFNLTGNWLPDETVE 88
Query: 348 SVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY---DNVDVV 518
+ +G+KGPL TPVG+G RSLN+ALR+ DLY +RP + +G+ + + VD+V
Sbjct: 89 AFRQYLVGIKGPLTTPVGRGIRSLNVALRQLLDLYVCLRPVRYFQGVPSPVKRPELVDMV 148
Query: 519 TIRENTEGEYSGIEH 563
RENTE Y+GIE+
Sbjct: 149 IFRENTEDIYAGIEY 163
Score = 39.9 bits (89), Expect = 0.087
Identities = 21/60 (35%), Positives = 33/60 (55%)
Frame = +3
Query: 591 IKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSDGLFLRCCRELATKYPGHQV 770
IK ++ + R+ A Q+A ++R+ VT VHK NIM+ ++G F LA + G V
Sbjct: 218 IKPVSRLGTERLVAAAIQYAITHRRRSVTFVHKGNIMKFTEGAFRDWGYALAERVFGEHV 277
>UniRef50_Q8U299 Cluster: 3-isopropylmalate dehydrogenase 2; n=3;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
2 - Pyrococcus furiosus
Length = 355
Score = 81.4 bits (192), Expect = 3e-14
Identities = 63/204 (30%), Positives = 96/204 (47%), Gaps = 14/204 (6%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITV----AVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSV 353
K+ +IPG GIG E+ ++KI E + V +++E A +P A++
Sbjct: 3 KIAVIPGDGIGKEVVAEGLKVLRKIEELSNVKFDFQEYPFGAEHYLKTGETLPDWALEEF 62
Query: 354 ---NANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY---DNVDV 515
+A G G G + L LR DLY N+RP K T + +D+
Sbjct: 63 RHFDAIYFGAIGDPRVKPGILEHGILLKLRFSLDLYVNLRPVKLYHPKLTPLKGKEKIDM 122
Query: 516 VTIRENTEGEYSGIEHEIVDGVVQSIKLI----TEEASTRVAEFAFQFARENKRKKVTAV 683
V IRENTEG Y+G + G + + T R FAF++A+ RKKVT V
Sbjct: 123 VFIRENTEGLYAGAGGFLRKGTPHEVAIQEMINTRFGVERTIRFAFEYAKTKGRKKVTLV 182
Query: 684 HKANIMRMSDGLFLRCCRELATKY 755
KAN++ + L+ R +E+A++Y
Sbjct: 183 DKANVLTYAHDLWQRVFKEVASEY 206
>UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=38; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Synechocystis sp. (strain PCC 6803)
Length = 475
Score = 79.8 bits (188), Expect = 9e-14
Identities = 55/154 (35%), Positives = 81/154 (52%), Gaps = 13/154 (8%)
Frame = +3
Query: 189 VTLIPGHGIGPEITVAVQKIFEAA--KVPIEWEEVDVTAVRGPD------GKFGI-PQKA 341
+ I G G G +I A + + AA K EE++ V D G + I P+
Sbjct: 29 IPYIRGDGTGVDIWPATELVINAAIAKAYGGREEINWFKVYAGDEACELYGTYQIFPEDT 88
Query: 342 IDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY---DNVD 512
+ ++ + +KGPL TPVG G RSLN+ALR+ FDLY VRPC+ G + + + +D
Sbjct: 89 LTAIKEYGVAIKGPLTTPVGGGIRSLNVALRQIFDLYTCVRPCRYYPGTPSPHKTPEKLD 148
Query: 513 VVTIRENTEGEYSGIE-HEIVDGVVQSIKLITEE 611
++ RENTE Y GIE E +G + I + +E
Sbjct: 149 IIVYRENTEDIYLGIEWAEGTEGAKKLIAYLNDE 182
>UniRef50_Q0X0C1 Cluster: Putative dehydrogenase; n=1; Streptomyces
lasaliensis|Rep: Putative dehydrogenase - Streptomyces
lasaliensis
Length = 362
Score = 79.0 bits (186), Expect = 2e-13
Identities = 68/217 (31%), Positives = 94/217 (43%), Gaps = 13/217 (5%)
Frame = +3
Query: 147 TRAGAAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDV----TAVRGPD 314
T + A T V + +IPG GIGPE+ + +A + + +D T +R +
Sbjct: 8 TCSARAGSETAVTTIAVIPGDGIGPEVIEPALDVLDALGLGTRTDILDHVNADTYLRTGE 67
Query: 315 GKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSL-EGIK 491
G I S A +G G R + LR E DLY N RP + + +
Sbjct: 68 ALTGSDLDRIRSSEAALLGAVGDPRLGDTSYVRGVLTTLRLELDLYVNYRPARLWHDRLS 127
Query: 492 TLYDN----VDVVTIRENTEGEYSGIEHEIVDG----VVQSIKLITEEASTRVAEFAFQF 647
L D +D V +RENTEG YSGI G + + L T +RV EFAF
Sbjct: 128 PLRDPARRAIDCVIVRENTEGLYSGIGGGARTGTPEEIAVDVDLSTRHGVSRVLEFAFSA 187
Query: 648 ARENKRKKVTAVHKANIMRMSDGLFLRCCRELATKYP 758
A R+ V V KAN +R L+ RC E ++P
Sbjct: 188 A----RRSVCLVDKANAVRNGGQLWQRCWGEAVARHP 220
>UniRef50_Q44471 Cluster: Probable tartrate
dehydrogenase/decarboxylase ttuC; n=66; cellular
organisms|Rep: Probable tartrate
dehydrogenase/decarboxylase ttuC - Agrobacterium vitis
(Rhizobium vitis)
Length = 364
Score = 79.0 bits (186), Expect = 2e-13
Identities = 66/208 (31%), Positives = 98/208 (47%), Gaps = 17/208 (8%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAAKVPI-EWEEVDVTAVRGPD--GKFGI--PQKAIDS 350
K+ IP GIGPE+ A ++ EA + +++ T G D K G+ P +D
Sbjct: 5 KIAAIPADGIGPEVIAAGLQVLEALEQRSGDFKIHTETFDWGSDYYKKHGVMMPADGLDK 64
Query: 351 V---NANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN----- 506
+ +A G G P L L + + FD YANVRP K L GI N
Sbjct: 65 LKKFDAIFFGAVGAPDVPDHITLWGLRLPICQGFDQYANVRPTKILPGITPPLRNCGPGD 124
Query: 507 VDVVTIRENTEGEYSG----IEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKV 674
+D V +REN+EGEYSG + + V + + T TR+ +AF+ A+ RK +
Sbjct: 125 LDWVIVRENSEGEYSGHGGRAHRGLPEEVGTEVAIFTRVGVTRIMRYAFKLAQARPRKLL 184
Query: 675 TAVHKANIMRMSDGLFLRCCRELATKYP 758
T V K+N R ++ E+AT++P
Sbjct: 185 TVVTKSNAQRHGMVMWDEIAAEVATEFP 212
>UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1;
Entamoeba histolytica HM-1:IMSS|Rep: tartrate
dehydrogenase - Entamoeba histolytica HM-1:IMSS
Length = 370
Score = 77.8 bits (183), Expect = 4e-13
Identities = 60/199 (30%), Positives = 93/199 (46%), Gaps = 8/199 (4%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 365
K+ +IPG GIG E+ +K+F++ +PI+ + VD +P ID V
Sbjct: 12 KIIVIPGDGIGAEVMNEAEKMFQSLNLPIQRDYVDWGIQHYLKTGKVVPIDYIDQVKQYD 71
Query: 366 IGLKGPLMTP-VGKGYRSLN--LALRKEFDLYANVRPCKSLEGIKTLYDN--VDVVTIRE 530
L G L P Y +L + +R++ D + +RP K GI T +DV+ +RE
Sbjct: 72 AILLGSLGDPRTLPDYVTLEPLIQMRQQLDQFLCLRPAKHFPGIPTPLKKCEIDVLVVRE 131
Query: 531 NTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKK---VTAVHKANIM 701
N+EGEYS I G + + + S R E ++A E RK+ VT K+N M
Sbjct: 132 NSEGEYSNIGGIFKSGTPEEFAIESAVHSRRGLERVIRYAFEASRKRRNHVTLATKSNAM 191
Query: 702 RMSDGLFLRCCRELATKYP 758
+ L+ +A +YP
Sbjct: 192 KFGMVLWDSVFEAIAMEYP 210
>UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9;
Euteleostomi|Rep: NAD+-isocitrate dehydrogenase - Homo
sapiens (Human)
Length = 133
Score = 75.8 bits (178), Expect = 1e-12
Identities = 40/107 (37%), Positives = 69/107 (64%), Gaps = 2/107 (1%)
Frame = +3
Query: 177 GVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVN 356
G VT++PG G+GPE+ AV+++F+AA VP+E++E ++ V+ + + Q + S+
Sbjct: 15 GAFPVTMLPGDGVGPELMHAVKEVFKAASVPVEFQEHHLSEVQNMASEEKLEQ-VLSSMK 73
Query: 357 ANKIGLKGPLMTPVG-KG-YRSLNLALRKEFDLYANVRPCKSLEGIK 491
NK+ + G + TP+ KG S ++ LR++ DL+ANV KSL G++
Sbjct: 74 ENKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVIHVKSLPGVQ 120
>UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular
organisms|Rep: Tartrate dehydrogenase - Burkholderia
mallei (Pseudomonas mallei)
Length = 361
Score = 73.7 bits (173), Expect = 6e-12
Identities = 65/218 (29%), Positives = 102/218 (46%), Gaps = 22/218 (10%)
Frame = +3
Query: 171 STGVRKVTLIPGHGIGPEITV-------AVQKIF--EAAKVPIEWEEVDVTAVRG---PD 314
S V ++ +IPG GIG E+ AV + F A PIEW D A G PD
Sbjct: 2 SEKVYRIAVIPGDGIGVEVMPEGLRALDAVSRRFGLRFAYEPIEWASCDYYAKHGQMMPD 61
Query: 315 GKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKT 494
+ +D++ +G P P + R+EFD Y N+RP + +G+
Sbjct: 62 D-WKTQLSGMDALLFGAVGW--PETVPDHISLWGSLIKFRREFDQYVNLRPARLFDGVPC 118
Query: 495 LY-----DNVDVVTIRENTEGEYSGIEHEIVDG-----VVQSIKLITEEASTRVAEFAFQ 644
++D + +RENTEGEYS + + +G VVQ + T + RV +FAF+
Sbjct: 119 PLAGRKAGDIDFMIVRENTEGEYSAVGGTMFEGTEREFVVQQ-AVFTRHGTERVLKFAFE 177
Query: 645 FARENKRKKVTAVHKANIMRMSDGLFLRCCRELATKYP 758
A + + K++T K+N + +S + E+A +YP
Sbjct: 178 LA-QRRAKRLTVATKSNGIAISMPWWDARAAEMAARYP 214
>UniRef50_A7GLU7 Cluster: Tartrate dehydrogenase; n=3; Bacteria|Rep:
Tartrate dehydrogenase - Bacillus cereus subsp.
cytotoxis NVH 391-98
Length = 364
Score = 73.7 bits (173), Expect = 6e-12
Identities = 61/211 (28%), Positives = 103/211 (48%), Gaps = 20/211 (9%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVT------AVRGPDGKF----GIPQ 335
KV +I G GIGPE+ K+ + + + + T GK GI Q
Sbjct: 5 KVAVIAGDGIGPEVMDEGVKVLQTIANVSQQFKFEFTYFPWGCEFYSKHGKMMDDDGIEQ 64
Query: 336 -KAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEG----IKTLY 500
KA D++ +G G P L L +R+ FD Y N+RP L+G +K +
Sbjct: 65 LKAFDAIYLGAVGFPG---VPDYISLWDLLLRIRQSFDQYVNIRPVTLLKGAPCPLKDVK 121
Query: 501 -DNVDVVTIRENTEGEYSGIEHEIVDG----VVQSIKLITEEASTRVAEFAFQFARENKR 665
+++D++ IREN+EGEY+G + G VV + + + + R+ +AF+ AR+ +R
Sbjct: 122 REDIDMLFIRENSEGEYAGAGDWLYKGKEHEVVLQNSVFSRKGTERIIRYAFEIARK-ER 180
Query: 666 KKVTAVHKANIMRMSDGLFLRCCRELATKYP 758
K +T++ K N + S + + E++ +YP
Sbjct: 181 KSLTSISKGNALNYSMVFWDQIFEEISKEYP 211
>UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase;
n=106; Bacteria|Rep: Tartrate
dehydrogenase/decarboxylase - Pseudomonas putida
Length = 365
Score = 73.3 bits (172), Expect = 8e-12
Identities = 62/212 (29%), Positives = 95/212 (44%), Gaps = 21/212 (9%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAAKVP---------IEWEEVDVTAVRG---PDGKFGI 329
++ IPG GIG E+ ++ EAA + EW D G PD +
Sbjct: 7 RIAAIPGDGIGLEVLPEGIRVLEAAALKHGLALEFDTFEWASCDYYLQHGKMMPDD-WAE 65
Query: 330 PQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN- 506
K D++ + + + + SL L R+EFD Y N+RP + G+ N
Sbjct: 66 QLKQYDAIYFGAVDWPDKVPDHISL-WGSL-LKFRREFDQYVNIRPVRLFPGVPCALANR 123
Query: 507 ----VDVVTIRENTEGEYS---GIEHEIVDG-VVQSIKLITEEASTRVAEFAFQFARENK 662
+D V +RENTEGEYS GI E + +V + T R+ ++AF A + +
Sbjct: 124 KVGDIDFVVVRENTEGEYSSLGGIMFENTENEIVIQESIFTRRGVDRILKYAFDLAEKRE 183
Query: 663 RKKVTAVHKANIMRMSDGLFLRCCRELATKYP 758
RK VT+ K+N M +S + + +A YP
Sbjct: 184 RKHVTSATKSNGMAISMPYWDKRTEAMAAHYP 215
>UniRef50_Q13FQ0 Cluster: Tartrate dehydrogenase; n=3;
Proteobacteria|Rep: Tartrate dehydrogenase -
Burkholderia xenovorans (strain LB400)
Length = 364
Score = 72.9 bits (171), Expect = 1e-11
Identities = 57/208 (27%), Positives = 95/208 (45%), Gaps = 17/208 (8%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAA-----KVPIEWEEVDVTAVRGPDGKFGIPQKAIDS 350
++ IPG GIG E+ A ++ EA E+E + +P +D+
Sbjct: 5 RIATIPGDGIGKEVIPAGAQVLEALARTSKSFAFEFENFGWGGDYYREHGVMMPADGLDA 64
Query: 351 V---NANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGI-----KTLYDN 506
+ +A G G P L L + + FD YANVRP + L GI + +
Sbjct: 65 IRNKDAILFGSAGDPDIPDHITLWGLRLKICQGFDQYANVRPTRILPGIDGPLKRCKPGD 124
Query: 507 VDVVTIRENTEGEYSGIEHEIVDG----VVQSIKLITEEASTRVAEFAFQFARENKRKKV 674
++ V +REN+EGEYSG+ + G + ++T R+ FAF+ A+ RK +
Sbjct: 125 LNWVIVRENSEGEYSGVGGRVHQGHPIEAATDVSILTRAGVERIMRFAFRLAQSRPRKLL 184
Query: 675 TAVHKANIMRMSDGLFLRCCRELATKYP 758
T + K+N R + L+ E++ ++P
Sbjct: 185 TVITKSNAQRHAMVLWDEIALEISKEFP 212
>UniRef50_Q8DTG3 Cluster: 3-isopropylmalate dehydrogenase; n=41;
Bacilli|Rep: 3-isopropylmalate dehydrogenase -
Streptococcus mutans
Length = 344
Score = 70.9 bits (166), Expect = 4e-11
Identities = 62/210 (29%), Positives = 100/210 (47%), Gaps = 18/210 (8%)
Frame = +3
Query: 180 VRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWE-EVDVTAVRG----------PDGKFG 326
++K+ + G GIGPEI A ++F+A I ++ E++ A G PD
Sbjct: 1 MKKIVTLAGDGIGPEIMAAGLEVFDAVAQKINFDYEIEAKAFGGAGIDASGHPLPDDTLA 60
Query: 327 IPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTL--- 497
K D++ IG PV + + L LA+RKE +L+AN+RP + + ++ L
Sbjct: 61 -AAKTADAILLAAIGSPQYDKAPV-RPEQGL-LAIRKELNLFANIRPVRIFDALRHLSPL 117
Query: 498 ----YDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKR 665
VD V +RE T G Y G +H + + I + R+ AF AR +
Sbjct: 118 KAERIAGVDFVVVRELTGGIYFG-QHTLTENSACDINEYSASEIRRIMRKAFAIAR-GRS 175
Query: 666 KKVTAVHKANIMRMSDGLFLRCCRELATKY 755
KKVT++ K N++ S L+ + E+A +Y
Sbjct: 176 KKVTSIDKQNVLATSK-LWRQIAEEVAKEY 204
>UniRef50_Q1IZK2 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Deinococcus geothermalis (strain DSM 11300)
Length = 351
Score = 68.5 bits (160), Expect = 2e-10
Identities = 55/192 (28%), Positives = 85/192 (44%), Gaps = 16/192 (8%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 365
KV +PG GIGPE+T A ++ + EE + PQ+ D++
Sbjct: 3 KVVTLPGDGIGPEVTAAAAEVLREVAPDVHIEEHAIGGAAYEQFGDPFPQRTRDALGDAD 62
Query: 366 IGLKGPLMTPVGKGYRSLN---------LALRKEFDLYANVRPCKSLEGIK-------TL 497
L G + + SL LALR+ YAN+RP + L G++ L
Sbjct: 63 AVLLGTVGGAQNSPWNSLPRPLRPESGLLALRRALGCYANLRPVRVLPGLEHLSPLKPEL 122
Query: 498 YDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVT 677
VD++ +RE G Y + +I + T RVA AF +A E +R +VT
Sbjct: 123 ARGVDILIVRELLGGIYFDGDRKIEGDTAYNTMRYTTPEVERVARVAF-WAAEQRRGRVT 181
Query: 678 AVHKANIMRMSD 713
+V KAN++ +S+
Sbjct: 182 SVDKANVLEVSE 193
>UniRef50_Q8E9N3 Cluster: 3-isopropylmalate dehydrogenase; n=148;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Shewanella oneidensis
Length = 364
Score = 66.9 bits (156), Expect = 7e-10
Identities = 61/214 (28%), Positives = 103/214 (48%), Gaps = 23/214 (10%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAAK----VPIEWEEVDVTAVRGPDGKFGIPQ------ 335
++ ++ G GIGPE+ +K+ +A + + IE+ E DV + + +P+
Sbjct: 4 QIAVLAGDGIGPEVMAEARKVLKAVEARFGLNIEYTEYDVGGIAIDNHGCPLPEATLKGC 63
Query: 336 KAIDSVNANKIG-LKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCK---SLEGIKTLYD 503
+A D++ +G K + P + R L LR F+L+ N+RP K LE + L
Sbjct: 64 EAADAILFGSVGGPKWEKLPPNEQPERGALLPLRGHFELFCNLRPAKLHDGLEHMSPLRS 123
Query: 504 NV-----DVVTIRENTEGEY----SGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARE 656
++ DV+ +RE T G Y G + E + +R+A AF+ AR
Sbjct: 124 DISARGFDVLCVRELTGGIYFGKPKGRQGEGESEEAFDTMRYSRREISRIARIAFEAAR- 182
Query: 657 NKRKKVTAVHKANIMRMSDGLFLRCCRELATKYP 758
+RKKVT+V KAN++ S L+ + E+A +P
Sbjct: 183 GRRKKVTSVDKANVLACS-VLWRQVVEEVAVDFP 215
>UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Saccharopolyspora erythraea NRRL 2338|Rep:
3-isopropylmalate dehydrogenase - Saccharopolyspora
erythraea (strain NRRL 23338)
Length = 407
Score = 65.7 bits (153), Expect = 2e-09
Identities = 63/208 (30%), Positives = 88/208 (42%), Gaps = 18/208 (8%)
Frame = +3
Query: 189 VTLIPGHGIGPEITVAVQKIFEAA---KVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNA 359
+ +IPG GIGPE+ + ++ AA V + + D A + ++ +
Sbjct: 9 IAVIPGDGIGPELVRSAVEVLRAAAGRDVELRFTSEDAGADAFRRTGSAMSAATLERIRT 68
Query: 360 NKIG-LKGP-----LMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN--VDV 515
G LKGP + P G L LR D YANVRP L G+ VD
Sbjct: 69 RYHGVLKGPVGLPGVRHPDGTEAGLLGGVLRGGLDTYANVRPIALLPGVDAPLRGTAVDY 128
Query: 516 VTIRENTEGEYSGIEHEI-VDGVVQSIKLITEEASTRVAEFAFQFARENKR------KKV 674
V +RENTEG Y + D L+T RV AF+ A ++V
Sbjct: 129 VIVRENTEGLYLSRGRGVGNDRACADQLLMTRHGVERVVVHAFELATRRTGAPADGVRRV 188
Query: 675 TAVHKANIMRMSDGLFLRCCRELATKYP 758
T V K+N++R S F E+AT+YP
Sbjct: 189 TCVDKSNVLR-SFAFFREVFDEVATRYP 215
>UniRef50_Q03UM1 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Leuconostocaceae|Rep: 3-isopropylmalate dehydrogenase -
Leuconostoc mesenteroides subsp. mesenteroides (strain
ATCC 8293 /NCDO 523)
Length = 357
Score = 65.3 bits (152), Expect = 2e-09
Identities = 58/194 (29%), Positives = 89/194 (45%), Gaps = 15/194 (7%)
Frame = +3
Query: 174 TGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDG--KFG--IPQKA 341
T V+K+ ++ G IGPEI A + +AA + + A G DG + G +PQ
Sbjct: 2 TSVKKIVVLKGDYIGPEIMTAGLAVLDAATKDTTFAYELIDAPFGGDGIDRAGDPLPQST 61
Query: 342 ID-SVNANKIGLK---GPLMTPVGKGYRSLNLALRKEFDLYANVRPCK------SLEGIK 491
ID S A+ + L GP + L +R + +L+AN+RP K +K
Sbjct: 62 IDVSKQADAVLLSAIGGPKWDNAPRRPEQGLLEIRSKLNLFANIRPTKVTAAQIDRSPLK 121
Query: 492 TLY-DNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRK 668
Y +N D V +RE T G Y G ++ +EE TR+ F+ A + + K
Sbjct: 122 PEYVENTDFVIVRELTSGAYFGKPRKLEAHQAIDTMYYSEEEVTRIMHQGFKMA-QKRNK 180
Query: 669 KVTAVHKANIMRMS 710
VT V K+N++ S
Sbjct: 181 HVTIVDKSNVLATS 194
>UniRef50_A5DIP7 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 173
Score = 65.3 bits (152), Expect = 2e-09
Identities = 46/102 (45%), Positives = 54/102 (52%)
Frame = -3
Query: 490 LIPSKLLQGLTLAYKSNSFLRAKLSDL*PLPTGVIRGPFKPILLAFTESIAFWGIPNLPS 311
L P L A SNSFL A +DL P GV + PF P L F +S A P S
Sbjct: 7 LTPGMFLIKTNEAKISNSFLNATFNDLPDDPVGVNKIPFNPTLFLFNDSTAS-ATPVPLS 65
Query: 310 GPLTAVTSTSSHSIGTLAASKIF*TATVISGPIPCPGMSVTL 185
P TST SHS+GT + K+ T +VIS PIP PGM VT+
Sbjct: 66 KP---ETSTVSHSMGTFSDLKMVLTESVISLPIPSPGMRVTV 104
>UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: LeuB
protein - Bradyrhizobium japonicum
Length = 359
Score = 64.9 bits (151), Expect = 3e-09
Identities = 58/209 (27%), Positives = 94/209 (44%), Gaps = 19/209 (9%)
Frame = +3
Query: 189 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFG--IPQ------KAI 344
+ ++ G GIGPE+ A + +A VD A K G P +
Sbjct: 7 IAVVHGDGIGPEVARAAVAVLQAGVQAGTLRFVDYPAGADHFLKTGDSFPAASFEGCRTA 66
Query: 345 DSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN---VDV 515
D++ G+ G + + L LR + DL+ANVRP K +G+ + +D
Sbjct: 67 DAILHGAAGIPGVVHPDGTEAGLDFTLTLRFKLDLFANVRPIKLYKGVPSPLGRPGPIDY 126
Query: 516 VTIRENTEGEYS--GIEHEIVDGVVQSIKLITEEASTRVAEFAFQFAR------ENKRKK 671
V +REN+EG Y+ G + + V + T + R+ FAF+ AR ++ R++
Sbjct: 127 VIVRENSEGLYAARGAGALLREEVAVDTLVQTRKGVERIVRFAFELARTRNGSPKDGRRR 186
Query: 672 VTAVHKANIMRMSDGLFLRCCRELATKYP 758
VT KAN++R + F E+A +YP
Sbjct: 187 VTCCDKANVLR-TYAFFRAVFDEVAKEYP 214
>UniRef50_Q8A6M0 Cluster: 3-isopropylmalate dehydrogenase; n=42;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
- Bacteroides thetaiotaomicron
Length = 353
Score = 64.9 bits (151), Expect = 3e-09
Identities = 59/210 (28%), Positives = 101/210 (48%), Gaps = 19/210 (9%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAA------KVPIEW-----EEVDVTAVRGPDGKFGIP 332
K+ ++ G GIGPEI+V + A KV E+ + +D P+ + +
Sbjct: 4 KIAVLAGDGIGPEISVQGVDVMSAVCEKFGHKVSYEYAICGADAIDKVGDPFPEETYEVC 63
Query: 333 QKAIDSVNANKIGLKGPLMTPVGKGYRSLNL-ALRKEFDLYANVRPCKSLEGI------- 488
+ A D+V + +G P K L A+RK+ L+AN+RP ++ + +
Sbjct: 64 KNA-DAVLFSAVGDPKFDNDPTAKVRPEQGLLAMRKKLGLFANIRPVQTFKCLIHKSPLR 122
Query: 489 KTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRK 668
L +N D + IRE T G Y G +++ D + T R+ + AF++A + +RK
Sbjct: 123 AELVENADFICIRELTGGMYFGEKYQDNDKAYDT-NYYTRPEIERILKVAFEYAMK-RRK 180
Query: 669 KVTAVHKANIMRMSDGLFLRCCRELATKYP 758
+T V KAN++ S L+ + +E+A YP
Sbjct: 181 HLTVVDKANVL-ASSRLWRQIAQEMAPNYP 209
>UniRef50_Q0W5L4 Cluster: 3-isopropylmalate dehydrogenase; n=10;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Uncultured methanogenic archaeon RC-I
Length = 380
Score = 64.1 bits (149), Expect = 5e-09
Identities = 56/231 (24%), Positives = 103/231 (44%), Gaps = 40/231 (17%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAAK----VPIEWEEVDVTAVRGPDGKFGIPQKAIDSV 353
KV +I G GIGPE+ +K+ AA+ +EW ++ +A I + ++ +
Sbjct: 5 KVPVIAGDGIGPEVIAEGRKVIAAAQEVYNFDVEWIDMPFSADHYVKTGETISESSLKEL 64
Query: 354 NANKIGLKGPL----MTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKT-----LYDN 506
+ + G + G + + L +R +D Y N+RP K +EG++T +
Sbjct: 65 SKYRAIFLGSIGDDRKVKPGVLEKGILLTMRFYYDQYVNLRPVKLMEGVETPLKGKTAAD 124
Query: 507 VDVVTIRENTEGEYSGI-----------EHEIV----------------DGVVQSIKLIT 605
+D +RENTE Y GI E E++ D + + +++
Sbjct: 125 IDFYVVRENTEDFYVGIGGRSKKGTSKQELEVIRQMYSVKFGLDVETDSDEIAYQLGVVS 184
Query: 606 EEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSDGLFLRCCRELATKYP 758
+E + R+ E++F A +K +++V KAN++ G + + A KYP
Sbjct: 185 KEGAKRIIEYSFDLANSRPKKHLSSVDKANVLTDIYGFWREVFTDTAAKYP 235
>UniRef50_A0P1S6 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Rhodobacterales|Rep: 3-isopropylmalate dehydrogenase -
Stappia aggregata IAM 12614
Length = 369
Score = 63.3 bits (147), Expect = 8e-09
Identities = 61/196 (31%), Positives = 95/196 (48%), Gaps = 25/196 (12%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAA-----KVPIEWEEVDVTA----VRGPDGKFGIPQK 338
K+ LI G GIG ++ A + E A + ++E+ A G D + G ++
Sbjct: 2 KIALIKGDGIGVDVAEAAIAVLETALKHTGEPAPRYDEIQAGAGYFKETGLDIEDGGEER 61
Query: 339 A--IDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGI-KTLYD-- 503
A D++ IGL P + S +L LR F LYA VRP K+ + L D
Sbjct: 62 AGLADAIFLGAIGL--PSIRHANGTEISPHLRLRDRFGLYAGVRPVKAYPNAPQRLADPR 119
Query: 504 --NVDVVTIRENTEG-EYSGIEHE----IVDGVVQSIKLITEEASTRVAEFAFQFARENK 662
+D+V +RE+TEG YS H+ + D VQ + IT + +T++ FAF AR+ +
Sbjct: 120 AAGIDLVILRESTEGLFYSAAAHKRSLVVNDDEVQDVLRITRKTTTKLHRFAFNLARKRR 179
Query: 663 RK----KVTAVHKANI 698
+ ++T V KAN+
Sbjct: 180 ERGHPGRLTCVDKANV 195
>UniRef50_Q48806 Cluster: Protein dlpA; n=4; Legionella
pneumophila|Rep: Protein dlpA - Legionella pneumophila
subsp. pneumophila (strain Philadelphia 1 /ATCC 33152 /
DSM 7513)
Length = 615
Score = 62.9 bits (146), Expect = 1e-08
Identities = 60/230 (26%), Positives = 100/230 (43%), Gaps = 34/230 (14%)
Frame = +3
Query: 171 STGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDS 350
ST K+ ++PG GIG E+T A +FE VP+ D+ IP +
Sbjct: 3 STDPIKIAVLPGDGIGIEVTEATLPVFEVLDVPVILNYGDIGWEFWKKEGAAIPSRTWQL 62
Query: 351 VNANKIGLKGPLMT-PVGKGYRSLNLALRKE--------------FDLYANVRPCKSLEG 485
+ ++ L G + + P + + L+ AL+K DL+ANVRPC S++
Sbjct: 63 IASSDTVLLGAITSKPQREAKQELSNALKKSNPYYVSPVIQLRQGLDLFANVRPCFSIDD 122
Query: 486 IKTLYDNVDVVTIRENTEGEYSGIE--------HEIV-----------DGVVQSIKLITE 608
+ + IREN+EG Y G + H ++ D +++L ++
Sbjct: 123 QSKPF---NFCIIRENSEGLYCGFDYFPLPKAIHSLLAESQHWQTIPADEASCALRLQSK 179
Query: 609 EASTRVAEFAFQFARENKRKKVTAVHKANIMRMSDGLFLRCCRELATKYP 758
TR+ +FAF+ A + +VT K N++R S + A +YP
Sbjct: 180 SGLTRLFDFAFKHAMQTGMPRVTLADKPNVLRESGEFTRKIFESTAQRYP 229
>UniRef50_A6GJ83 Cluster: Isocitrate dehydrogenase; n=1;
Plesiocystis pacifica SIR-1|Rep: Isocitrate
dehydrogenase - Plesiocystis pacifica SIR-1
Length = 344
Score = 62.1 bits (144), Expect = 2e-08
Identities = 53/194 (27%), Positives = 82/194 (42%), Gaps = 1/194 (0%)
Frame = +3
Query: 204 GHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGP 383
G GI E++ AV + +A IE+ VD++ I +A ++ LK P
Sbjct: 16 GDGIARELSQAVHTVADALPFEIEFIPVDLSDESREAKGDAIYDEAEAAMRRYGTSLKYP 75
Query: 384 LMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY-DNVDVVTIRENTEGEYSGIE 560
T S N LR+ + RP ++ GI+T Y + + + +R T G Y
Sbjct: 76 TATTK----ESPNRVLRERCNFAVIHRPVATIPGIQTHYNERIHLDIVRIATGGTYEDAG 131
Query: 561 HEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSDGLFLRCCRE 740
I SI+ I S + FAF+ A + + V A K I + +DGLF R
Sbjct: 132 RRINRDTAVSIRAIERRPSVLASRFAFRLA-QLRDSNVIATSKYTIQKATDGLFQEAARG 190
Query: 741 LATKYPGHQVRRAI 782
+A YP + R +
Sbjct: 191 VARDYPATEFREEL 204
>UniRef50_Q89RJ1 Cluster: 3-isopropylmalate dehydrogenase; n=7;
Alphaproteobacteria|Rep: 3-isopropylmalate dehydrogenase
- Bradyrhizobium japonicum
Length = 368
Score = 61.7 bits (143), Expect = 2e-08
Identities = 57/220 (25%), Positives = 100/220 (45%), Gaps = 18/220 (8%)
Frame = +3
Query: 153 AGAAQYSTGVRKVTLIPGHGIGPEITV----AVQKIFEAAKVPIEWEEVDVTAVRGPDGK 320
AG + + ++ G GIGPE+ ++KI + + + + E A
Sbjct: 6 AGTPMSANNAFHIAVLAGDGIGPEVMAPAIEVLRKIEQKSDLRFRFTEAPAGANNYLATG 65
Query: 321 FGIPQKAI---DSVNANKIGLKG-PLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGI 488
+P++ I + +A +G G P + + + LR FDLYA VRP + + G+
Sbjct: 66 KSMPERTIKLCEEADAILLGACGLPSVRYPDNTEIAPQIELRFIFDLYAGVRPARLIPGV 125
Query: 489 KTLY-----DNVDVVTIRENTEGEYSGIEHEIVDGV-VQSIKLITEEASTRVAEFAFQFA 650
+ +D+V IRE+TEG ++ + +V + +IT S R+ EF+F+ A
Sbjct: 126 PSPIVGADTRGIDLVVIRESTEGLFASMGKGVVTHEDARETMVITRRTSERLFEFSFRLA 185
Query: 651 RENKRK----KVTAVHKANIMRMSDGLFLRCCRELATKYP 758
K + +T V KAN+ + + F E+A K+P
Sbjct: 186 ARRKARGKPGMLTCVDKANVFK-AFAFFRGIFDEIAKKHP 224
>UniRef50_Q8YCX4 Cluster: 3-isopropylmalate dehydrogenase; n=126;
Bacteria|Rep: 3-isopropylmalate dehydrogenase - Brucella
melitensis
Length = 370
Score = 61.3 bits (142), Expect = 3e-08
Identities = 63/198 (31%), Positives = 92/198 (46%), Gaps = 24/198 (12%)
Frame = +3
Query: 183 RKVTLIPGHGIGPEITVAVQKIF----EAAKVPIEWEEVDVTA----VRGPDGKFGIPQK 338
RK+ L+PG GIGPE V+K+ + E EE V G +K
Sbjct: 4 RKLLLLPGDGIGPEAMAEVRKVIAFLNSDLNLGFETEEGLVGGCAYDAHGQAISDADMEK 63
Query: 339 AI--DSVNANKIGLKGPLMTPVGKGYRSLN--LALRKEFDLYANVRPCKSLEGI------ 488
A+ D+V +G GP V R L LRK+ LYAN+RP +
Sbjct: 64 ALAADAVLFGAVG--GPKWDSVPYEVRPEGGLLRLRKDMQLYANLRPAICYPALAHSSSL 121
Query: 489 -KTLYDNVDVVTIRENTEGEYSGIEHEIVD-GVVQSIKLITEEAST----RVAEFAFQFA 650
+ + +D++ +RE T G Y G EI+D G Q + T+ T R+A+ AF+ A
Sbjct: 122 KPEVIEGLDILILRELTGGVYFGEPKEIIDLGNGQKRGIDTQVYDTYEIERIADVAFELA 181
Query: 651 RENKRKKVTAVHKANIMR 704
R +R KVT++ K N+M+
Sbjct: 182 R-TRRNKVTSMEKRNVMK 198
>UniRef50_Q1IMD5 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Acidobacteria bacterium Ellin345|Rep: 3-isopropylmalate
dehydrogenase - Acidobacteria bacterium (strain
Ellin345)
Length = 403
Score = 59.7 bits (138), Expect = 1e-07
Identities = 58/238 (24%), Positives = 104/238 (43%), Gaps = 48/238 (20%)
Frame = +3
Query: 189 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKI 368
V +PG GIG ++ ++ EA + D+ + +P + I + +K+
Sbjct: 6 VVTMPGDGIGNQVLPQAIRVLEAVGFEANYVHADIGWECWCNEGNALPDRTIQLLRKHKL 65
Query: 369 GLKGPLMTPV-------------GKG--YRSLNLALRKEFDLYANVRPCKSLEGIKTLY- 500
GL G + + GKG Y S + +R+ F+L +RPC S G +
Sbjct: 66 GLFGAITSKPKKAADAELKPELRGKGLSYFSPIVTMRQLFNLDVCMRPCLSFPGNPLNFI 125
Query: 501 ----------DNVDVVTIRENTEGEYSGIE--------------HEIV--------DGVV 584
VDVV R+NTEG Y+G+E H+ + +
Sbjct: 126 RQTTCGGFEEPQVDVVVFRQNTEGLYAGVEWTNPPENVRTALASHKKFAAFANTPGEELA 185
Query: 585 QSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSDGLFLRCCRELATKYP 758
S+++IT++ + R+ E AF+ A++ + K VT K N++R + G+ +++ +YP
Sbjct: 186 VSVRIITKKNAQRICEAAFKHAKKYRYKNVTICEKPNVLRETSGMMEEVAKQVQKQYP 243
>UniRef50_Q81T67 Cluster: 3-isopropylmalate dehydrogenase; n=9;
Bacillus cereus group|Rep: 3-isopropylmalate
dehydrogenase - Bacillus anthracis
Length = 354
Score = 59.7 bits (138), Expect = 1e-07
Identities = 56/207 (27%), Positives = 91/207 (43%), Gaps = 15/207 (7%)
Frame = +3
Query: 183 RKVTLIPGHGIGPEITVAVQKIFEAAK------VPIEWEEVDVTAVRGPDGKFGIPQKAI 344
+++ + G G+GPE+ + +++ + ++ E A+ G+ +PQ+ +
Sbjct: 3 KRIVCLAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEHFGGVAI-DLTGQ-PLPQRTL 60
Query: 345 DSVNANKIGLKGPLMTPVGKGYRSLN----LALRKEFDLYANVRPCKSLEGIKTLY---- 500
+ A+ L G + P G + LALRK ++ANVRP L
Sbjct: 61 AACLASDAVLLGAVGGPRWDGAKERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLKK 120
Query: 501 -DNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVT 677
D +D V +RE T G Y E D V R+ AFQ A + K KKVT
Sbjct: 121 ADEIDFVVVRELTGGIYFSYPKERTDEVATDTLTYHRHEIERIVSCAFQLASKRK-KKVT 179
Query: 678 AVHKANIMRMSDGLFLRCCRELATKYP 758
++ KAN++ S L+ E+A +YP
Sbjct: 180 SIDKANVLE-SSKLWRIVTEEVALRYP 205
>UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2;
Bacillaceae|Rep: Tartrate dehydrogenase - Bacillus sp.
B14905
Length = 362
Score = 58.4 bits (135), Expect = 2e-07
Identities = 50/188 (26%), Positives = 87/188 (46%), Gaps = 18/188 (9%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGP--------DGKFGIPQKA 341
K+ +IPG GIG E+ K+ + V + +T + P G+ +P+ A
Sbjct: 5 KMAVIPGDGIGKEVMQEALKVVKC--VQERDSSLQITTMVFPWSSDYYLAHGRM-MPEDA 61
Query: 342 IDSV---NANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY---D 503
++++ +A G G P L + +RK F Y N RP KSL GI + +
Sbjct: 62 LETLQKYDAILFGAIGDARVPDDVTVWELIMPIRKNFQQYVNFRPIKSLPGISSPLAGGN 121
Query: 504 NVDVVTIRENTEGEYSGIEHEIVDGVVQSI----KLITEEASTRVAEFAFQFARENKRKK 671
++D V REN EGEYS + Q + ++T ++ A ++A+++ + K
Sbjct: 122 DIDFVIFRENAEGEYSDSGGRLYQQQPQEMTIQNTIMTRIGIEKIVRAACEYAQQHGKTK 181
Query: 672 VTAVHKAN 695
+T+ K+N
Sbjct: 182 LTSATKSN 189
>UniRef50_Q67LW7 Cluster: Tartrate dehydrogenase; n=2; Bacteria|Rep:
Tartrate dehydrogenase - Symbiobacterium thermophilum
Length = 359
Score = 58.0 bits (134), Expect = 3e-07
Identities = 54/190 (28%), Positives = 84/190 (44%), Gaps = 21/190 (11%)
Frame = +3
Query: 189 VTLIPGHGIGPEITVAVQKIFEAAK-----VPIEWEEVDVTAV-------RGPDGKFGIP 332
V +IPG GIG E A +++ +AA + E+ E + P G F
Sbjct: 6 VAVIPGDGIGNETVRAGRRVLDAAAELDGGIKFEYTEFEWGCAYYLRHGEMAPKG-FLNT 64
Query: 333 QKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY---- 500
D++ +G G P L L +R+ F+ Y N+RP + L G+ +
Sbjct: 65 LANFDTILLGAVGYPG---VPDHVSLWGLLLPIRRGFEQYVNLRPVRILRGVVSPLRGRN 121
Query: 501 -DNVDVVTIRENTEGEYSGIEHEIVDG----VVQSIKLITEEASTRVAEFAFQFARENKR 665
+V+ V IRENTEGEYS + + G VV + T + R+ +A+Q A R
Sbjct: 122 PGDVNFVCIRENTEGEYSNMGGRLHAGLPHEVVVQNTVFTRVGTERIIRYAYQLAANAPR 181
Query: 666 KKVTAVHKAN 695
K++ K+N
Sbjct: 182 KRLCGATKSN 191
>UniRef50_Q4V533 Cluster: IP13250p; n=4; Drosophila
melanogaster|Rep: IP13250p - Drosophila melanogaster
(Fruit fly)
Length = 475
Score = 58.0 bits (134), Expect = 3e-07
Identities = 39/170 (22%), Positives = 83/170 (48%), Gaps = 1/170 (0%)
Frame = +3
Query: 177 GVRKVTLIPGHGI-GPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSV 353
G+ V+L+ G I G + V + +++VP+E + ++ G D ++ SV
Sbjct: 61 GINTVSLVTGTTIIGQQGAQFVSSLLSSSRVPVEVQVIEA----GQDDEY------FHSV 110
Query: 354 NANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIREN 533
N+ + ++L + + DLY +S G K + VD+ I +N
Sbjct: 111 LRNRTAVHVDNQADAEAKQKALKIC--NDLDLYVFKTRTRSFPGFKCRFPGVDIQLIGQN 168
Query: 534 TEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAV 683
G ++ +E+ V+GVV+++ +++++ + + +AF+ A + RK+VT +
Sbjct: 169 NMGIFNELEYSPVEGVVEALSVVSQKGNDKYLRYAFKAAAKAGRKRVTLI 218
>UniRef50_Q7UTP0 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodopirellula baltica
Length = 364
Score = 56.8 bits (131), Expect = 7e-07
Identities = 51/188 (27%), Positives = 84/188 (44%), Gaps = 17/188 (9%)
Frame = +3
Query: 189 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKF-----GIPQKAIDSV 353
+ ++ G GIGPE+ ++ E + ++ E + G++ +PQ A D+
Sbjct: 7 LVILGGDGIGPEVCDQSVRLLEIMQPHLDGVEFQLDRHSVGVGEYQRSGEALPQSAYDAC 66
Query: 354 NANKIGLKGPLMTPVGKGYRSLNLA----LRKEFDLYANVRPCKSLEGIKTLYDN----- 506
A+ L G + P + +A LR+ LY VRP + T
Sbjct: 67 LASDAVLLGAMGLPNVRYPNGKEIAPQLDLRERLQLYGGVRPIRLYHEADTPLKGHGPGE 126
Query: 507 VDVVTIRENTEGEYSGIE--HEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKK-VT 677
+D V +RE+TEG + G + ++ ++ IT AS RV AF+ AR KK VT
Sbjct: 127 IDFVLVRESTEGLFYGRDAIADLEADEATNLLRITRSASERVCRLAFETARRRDGKKTVT 186
Query: 678 AVHKANIM 701
+ KAN++
Sbjct: 187 LIDKANVL 194
>UniRef50_Q7VH33 Cluster: 3-isopropylmalate dehydrogenase; n=11;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Helicobacter hepaticus
Length = 357
Score = 56.0 bits (129), Expect = 1e-06
Identities = 56/198 (28%), Positives = 90/198 (45%), Gaps = 22/198 (11%)
Frame = +3
Query: 183 RKVTLIPGHGIGPEITVAVQKIFEAAKVPIE----WEEVDVTAVRGPDGKFGIPQKAIDS 350
+++ +I G GIG E+ KI +A E +EEV + +P K++
Sbjct: 3 KRIAVIYGDGIGKEVITQALKILKAVAKKYEHTFIFEEVLAGGAAIDECGECLPMKSLQI 62
Query: 351 VNANKIGLKGPLMTPVGKGYRSLN------LALRKEFDLYANVRPCKSLEGI-------- 488
+ L G + P S N L LRKE L+AN+RP L +
Sbjct: 63 CKQSDSVLLGAVGGPKWDNEPSHNRPEKALLTLRKELGLFANIRPATLLPQLSKASPLKD 122
Query: 489 KTLYDNVDVVTIRENTEGEYSGIEHEI--VDGVVQSIKLITEEAS--TRVAEFAFQFARE 656
+ L +D + +RE G Y G EH++ ++G + +T AS +A+ AF AR
Sbjct: 123 EILNRGIDFIIVRELIGGVYFG-EHKLEEINGEKVASDAMTYSASQIESIAKVAFNIAR- 180
Query: 657 NKRKKVTAVHKANIMRMS 710
N++K++ V KAN++ S
Sbjct: 181 NRKKEIVCVDKANVLSSS 198
>UniRef50_Q9FMT1 Cluster: 3-isopropylmalate dehydrogenase 3,
chloroplast precursor; n=186; cellular organisms|Rep:
3-isopropylmalate dehydrogenase 3, chloroplast precursor
- Arabidopsis thaliana (Mouse-ear cress)
Length = 409
Score = 54.4 bits (125), Expect = 4e-06
Identities = 66/228 (28%), Positives = 105/228 (46%), Gaps = 25/228 (10%)
Frame = +3
Query: 150 RAGAAQYSTGVRKVTLIPGHGIGPE-ITVA---VQKI-------FEAAKVPIEWEEVDVT 296
R AA + L+PG GIGPE I+VA +QK F+ ++P+ +D+
Sbjct: 36 RCAAASPGKKRYNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFKEMPVGGAALDLV 95
Query: 297 AVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYR--SLNLALRKEFDLYANVRPC 470
V P+ F K D++ IG G K R LR++ ++AN+RP
Sbjct: 96 GVPLPEETF-TAAKLSDAILLGAIG--GYKWDKNEKHLRPEMALFYLRRDLKVFANLRPA 152
Query: 471 KSLEGI-------KTLYDNVDVVTIRENTEGEYSGIEHEIV-----DGVVQSIKLITEEA 614
L + K + + VD++ +RE T G Y G I + V S ++
Sbjct: 153 TVLPQLVDASTLKKEVAEGVDMMIVRELTGGIYFGEPRGITINENGEEVGVSTEIYAAHE 212
Query: 615 STRVAEFAFQFARENKRKKVTAVHKANIMRMSDGLFLRCCRELATKYP 758
R+A AF+ AR+ +R K+ +V KAN++ S L+ + LA++YP
Sbjct: 213 IDRIARVAFETARK-RRGKLCSVDKANVLDASI-LWRKRVTALASEYP 258
>UniRef50_P56471 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 90
Score = 54.0 bits (124), Expect = 5e-06
Identities = 24/33 (72%), Positives = 28/33 (84%)
Frame = +3
Query: 177 GVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIE 275
GV+ VTLIPG GIGPEI+ AV KIF+AAK PI+
Sbjct: 3 GVKTVTLIPGDGIGPEISAAVMKIFDAAKAPIQ 35
>UniRef50_Q2JTN8 Cluster: 3-isopropylmalate dehydrogenase; n=72;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria
bacteriumYellowstone A-Prime)
Length = 381
Score = 53.2 bits (122), Expect = 9e-06
Identities = 63/222 (28%), Positives = 106/222 (47%), Gaps = 26/222 (11%)
Frame = +3
Query: 171 STGVR--KVTLIPGHGIGPEITVAVQKIFE--AAKV--PIEWEE-------VDVTAVRGP 311
S+ VR ++T + G GIGPEI + + + AA+V ++W+E + T P
Sbjct: 5 SSAVRTYRITALAGDGIGPEIMQVGRAVLDAVAAQVGFSLQWQEGLIGGAAYEATGDPLP 64
Query: 312 DGKFGIPQKAIDSVNANKIG-LKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCK----- 473
+ Q++ D+V +G K + + R+L L LR L+AN+RP K
Sbjct: 65 PETLKMAQES-DAVYLAAVGDFKYDTLPREKRPERAL-LGLRAGLGLFANLRPVKIFPQL 122
Query: 474 -SLEGIK-TLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLI-----TEEASTRVAE 632
+K + +D+V +RE T G Y G I S + + +E R+A
Sbjct: 123 VQASSLKPEVVAGIDLVVVRELTGGIYFGQPKGIFTDAKGSRRGVNTMAYSEAEVDRIAR 182
Query: 633 FAFQFARENKRKKVTAVHKANIMRMSDGLFLRCCRELATKYP 758
AF+ AR+ +R+K+ +V KAN++ +S L+ +A +YP
Sbjct: 183 VAFELARK-RRRKLCSVDKANVLEVSQ-LWRERVTAIAAEYP 222
>UniRef50_A6PN62 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Victivallis vadensis ATCC BAA-548|Rep: 3-isopropylmalate
dehydrogenase - Victivallis vadensis ATCC BAA-548
Length = 369
Score = 52.4 bits (120), Expect = 2e-05
Identities = 47/178 (26%), Positives = 77/178 (43%), Gaps = 16/178 (8%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAAK----VPIEWEEVDVTAVRGPDGKFGIPQKAIDSV 353
K+ ++PG G GPE+ K+ +AA E E + +P A + +
Sbjct: 6 KIAVLPGDGTGPEVIAEAVKVLDAAGRKFGFTTEKEYYNWGGAHYLATGETLPADAKEQL 65
Query: 354 NANKIGLKGPLMTP-VGKGYRSLNLALRKEFDL--YANVRPCKSLEGIKTLYDN-----V 509
+ L G + P V G + L+ FDL Y N+RP K G++T N +
Sbjct: 66 ARHDAVLLGAIGHPDVKPGVLEKGILLKLRFDLDQYINLRPVKLFPGVETPLANKKPEDI 125
Query: 510 DVVTIRENTEGEYSG----IEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKK 671
D V +REN+ G Y+G ++ + + V + T R +FAF+ A + K+
Sbjct: 126 DYVVVRENSGGVYTGMGGNVQIDTPEEVACQNWIYTRSQVDRCLKFAFELAEKRHTKE 183
>UniRef50_Q300E7 Cluster: Isocitrate/isopropylmalate dehydrogenase;
n=1; Streptococcus suis 89/1591|Rep:
Isocitrate/isopropylmalate dehydrogenase - Streptococcus
suis 89/1591
Length = 207
Score = 52.0 bits (119), Expect = 2e-05
Identities = 50/193 (25%), Positives = 80/193 (41%), Gaps = 15/193 (7%)
Frame = +3
Query: 183 RKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWE-EVDVTAVRGPD---GKFGIPQKAIDS 350
+K+ + G GIGPEI A ++ EA + ++ E++ A G +P + +
Sbjct: 3 KKIVALAGDGIGPEIMEAGLEVLEAVAGQVGFDYEIEERAFGGAGIDAAGHPLPNATLQA 62
Query: 351 VN-ANKI---GLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTL------- 497
A+ I + P L LRKE L+AN+RP K + +K
Sbjct: 63 CRQADAILLAAIGSPQYDDAAVRPEQGLLQLRKELGLFANIRPVKIFDSLKDYSPLKADR 122
Query: 498 YDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVT 677
D VD+V +RE T G Y G +H + E RV AF A++ ++K
Sbjct: 123 LDGVDLVMVRELTGGIYFG-KHILETYQASDSNTYQAEEIERVVRSAFDLAQKRQKKSPA 181
Query: 678 AVHKANIMRMSDG 716
+ + R + G
Sbjct: 182 LISRMYWRRQNYG 194
>UniRef50_P04173 Cluster: 3-isopropylmalate dehydrogenase; n=41;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
- Saccharomyces cerevisiae (Baker's yeast)
Length = 364
Score = 51.6 bits (118), Expect = 3e-05
Identities = 56/198 (28%), Positives = 82/198 (41%), Gaps = 22/198 (11%)
Frame = +3
Query: 183 RKVTLIPGHGIGPEITVAVQKIFEA-----AKVPIEWEE-------VDVTAVRGPDGKFG 326
+K+ ++PG +G EIT K+ +A + V ++E +D T V PD
Sbjct: 5 KKIVVLPGDHVGQEITAEAIKVLKAISDVRSNVKFDFENHLIGGAAIDATGVPLPDEALE 64
Query: 327 IPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCK-------SLEG 485
+KA D+V +G GP L +RKE LYAN+RPC L
Sbjct: 65 ASKKA-DAVLLGAVG--GPKWGTGSVRPEQGLLKIRKELQLYANLRPCNFASDSLLDLSP 121
Query: 486 IKTLY-DNVDVVTIRENTEGEYSGIEHE-IVDGVVQSIKLITEEASTRVAEF-AFQFARE 656
IK + D V +RE G Y G E DGV + T R+ AF +
Sbjct: 122 IKPQFAKGTDFVVVRELVGGIYFGKRKEDDGDGVAWDSEQYTVPEVQRITRMAAFMALQH 181
Query: 657 NKRKKVTAVHKANIMRMS 710
+ ++ KAN++ S
Sbjct: 182 EPPLPIWSLDKANVLASS 199
>UniRef50_Q89XA0 Cluster: 3-isopropylmalate dehydrogenase 1; n=3;
Bacteria|Rep: 3-isopropylmalate dehydrogenase 1 -
Bradyrhizobium japonicum
Length = 379
Score = 50.8 bits (116), Expect = 5e-05
Identities = 58/198 (29%), Positives = 91/198 (45%), Gaps = 24/198 (12%)
Frame = +3
Query: 189 VTLIPGHGIGPEITVAVQKIF----EAAKVPIEWEEVDVTAVRG-PDGKFGIPQKAIDSV 353
V ++ G GIGPE+T +I + P+ E + GK +P ++++
Sbjct: 10 VAVVGGEGIGPEVTDQSHRILKWFSDRRGAPVILREAQYGLIPYLATGKV-LPDDTVEAM 68
Query: 354 N-ANKI---GLKGPLMTPVGKGYRSLN--LALRKEFDLYANVRPCKSLEGI-------KT 494
A+ I GP T V R L+LR ++DLYAN+RP + +
Sbjct: 69 EEADAILWGATGGPETTEVPPAARKAGSLLSLRSKYDLYANLRPIVANPALADSAPLKAA 128
Query: 495 LYDNVDVVTIRENTEGEY----SGIEHEIVDGVVQ--SIKLITEEASTRVAEFAFQFARE 656
+ +VD + IRE T G Y GIE + DG + + + T RVA AF+ AR
Sbjct: 129 VLKDVDFIIIRELTSGIYFGEPRGIE-TLPDGQRRGFNTQQYTTSQIRRVARTAFELAR- 186
Query: 657 NKRKKVTAVHKANIMRMS 710
++ +V +V KAN++ S
Sbjct: 187 TRKGRVCSVDKANVLETS 204
>UniRef50_Q12545 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Hypocreales|Rep: 3-isopropylmalate dehydrogenase -
Cephalosporium acremonium (Acremonium chrysogenum)
Length = 380
Score = 50.4 bits (115), Expect = 6e-05
Identities = 59/217 (27%), Positives = 92/217 (42%), Gaps = 24/217 (11%)
Frame = +3
Query: 174 TGVRKVTLIPGHGIGPEITVAVQKIFEAAKV--PIEWEEVDVTAVRGPD-GKFGIP--QK 338
T K+ ++PG IGPEI K+ + P + V G G+P Q
Sbjct: 2 TTTYKILVLPGDHIGPEIMAEAIKVLTTIETHRPNLHFNLTTDLVGGTSIDTHGVPITQS 61
Query: 339 AIDSVNANKIGLKGPLMTPVGKGYR----SLNLALRKEFDLYANVRPCK----SLEGIKT 494
+D+ A+ L G + P G S L LR+ D +AN+RPC+ SL G
Sbjct: 62 VLDAAKASDAVLFGSIGGPEWAGVHPTPESGLLQLRQHLDAFANLRPCEFLVPSLVGASP 121
Query: 495 LYDNV----DVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFAR--- 653
+ ++V + +REN G Y G + E D V + + T R+A + AR
Sbjct: 122 IREHVVKGTRFIVVRENCGGAYFGEKKEEED-VASDLWVYTRPEIERLARVSAAVARIMG 180
Query: 654 ----ENKRKKVTAVHKANIMRMSDGLFLRCCRELATK 752
+N+ V + KAN++ S L+ R ++ K
Sbjct: 181 RSEDDNQAATVWSADKANVL-ASGRLWRRITSDIFAK 216
>UniRef50_Q05FQ8 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Candidatus Carsonella ruddii PV|Rep: 3-isopropylmalate
dehydrogenase - Carsonella ruddii (strain PV)
Length = 349
Score = 50.0 bits (114), Expect = 8e-05
Identities = 50/186 (26%), Positives = 86/186 (46%), Gaps = 17/186 (9%)
Frame = +3
Query: 195 LIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPD-GKFGIPQ--------KAID 347
++PG GIGPEI V KI ++ + + G KF P K ID
Sbjct: 6 ILPGDGIGPEIIKQVIKIVKSCIYTGYKINIIYNYIGGISIDKFNTPITNNLISIIKYID 65
Query: 348 SVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIR 527
++ +G + K L L LRK+F+ + N+RP IK + N+D++ +R
Sbjct: 66 TIFLGCVG-GYKWNHSIFKPEYGL-LKLRKKFNFFTNIRP------IKCPFKNIDIIIVR 117
Query: 528 ENTEGEY----SGIEHEIVDGV----VQSIKLITEEASTRVAEFAFQFARENKRKKVTAV 683
E G Y G +I++ + + K+ E+ R+A +F A N++KK+ ++
Sbjct: 118 ELNGGIYYGKPKGFSKQIINQIPTWYAYNTKIYNEQEIIRLARISFNLAL-NRKKKLCSI 176
Query: 684 HKANIM 701
K+N++
Sbjct: 177 DKSNVL 182
>UniRef50_A6G3V7 Cluster: Probable 3-isopropylmalate dehydrogenase;
n=1; Plesiocystis pacifica SIR-1|Rep: Probable
3-isopropylmalate dehydrogenase - Plesiocystis pacifica
SIR-1
Length = 368
Score = 49.6 bits (113), Expect = 1e-04
Identities = 48/153 (31%), Positives = 73/153 (47%), Gaps = 23/153 (15%)
Frame = +3
Query: 369 GLKGPLMTPVGK--GYRSLNLALRKEFDLYANVRPCKSLEGI--------KTLYD--NVD 512
G GP++ K G+ + + R +LYANVRP K G+ K +++ VD
Sbjct: 65 GTGGPVLMKDNKMAGFSPV-IGNRMRLNLYANVRPIKLYPGVQHRIHGGHKQIWEAGKVD 123
Query: 513 VVTIRENTEGEYSGIEHEIVDG----VVQSIKLITEEASTRVAEFAFQFA-RENK----- 662
+V IRENTEG Y+ ++ G V ++IT A +V AF+ R NK
Sbjct: 124 MVIIRENTEGLYAPTGGKLAPGGKADVAIDTRVITRRACEQVIRHAFELCKRRNKGAPKD 183
Query: 663 -RKKVTAVHKANIMRMSDGLFLRCCRELATKYP 758
+ +VTA+ K N++ LF E+ +YP
Sbjct: 184 GKLRVTAIIKDNVLHGCQ-LFRDVFFEIGAEYP 215
>UniRef50_Q7UIE1 Cluster: 3-isopropylmalate dehydrogenase; n=4;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodopirellula baltica
Length = 359
Score = 49.2 bits (112), Expect = 1e-04
Identities = 60/215 (27%), Positives = 93/215 (43%), Gaps = 22/215 (10%)
Frame = +3
Query: 189 VTLIPGHGIGPEIT----VAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSV- 353
+ L+PG GIGPEI + + K+ E ++ + + + +PQ ID+
Sbjct: 5 IVLLPGDGIGPEIVEQARLVLVKVAERFGHTFDFSSHQIGGIAIDETGDPLPQPTIDACR 64
Query: 354 NANKI---GLKGPLM-TPVGKGYRSLN-LALRKEFDLYANVRPCKSLEGI-------KTL 497
NA I + GP P K L +RKE L+AN+RP K + + +
Sbjct: 65 NAAAILLGAVGGPKWDDPSAKTRPEAGLLKIRKELGLFANLRPIKLFDELADASPLRADI 124
Query: 498 YDNVDVVTIRENTEGEYSGIEHEIVDG----VVQSIKLITEEASTRVAEFAFQFARENKR 665
D++ RE T G Y G G QS+ E R+ A Q AR +
Sbjct: 125 VKGTDILFFRELTGGIYFGESGTSGSGEEETAFQSMTYSVGEVK-RIVRMAAQAAR-GRS 182
Query: 666 KKVTAVHKANIMRMSDGLFLRCCRE-LATKYPGHQ 767
++T+V KAN++ S L+ R E +A ++P Q
Sbjct: 183 NRLTSVDKANVLEPS-RLWRRVAAEVMANEFPDVQ 216
>UniRef50_UPI00003C8595 Cluster: hypothetical protein Faci_03000731;
n=1; Ferroplasma acidarmanus fer1|Rep: hypothetical
protein Faci_03000731 - Ferroplasma acidarmanus fer1
Length = 377
Score = 48.0 bits (109), Expect = 3e-04
Identities = 39/129 (30%), Positives = 62/129 (48%), Gaps = 12/129 (9%)
Frame = +3
Query: 198 IPGHGIGPEITVAVQKIFEAA-------KVPIEWEEVDVTAVRGPDGKFG--IPQKAIDS 350
I G GIGPEIT A+ + +A IEW ++ + KFG +P+ +I
Sbjct: 29 IDGDGIGPEITGAMIGVVNSAIELAYQGSRSIEWHKILIGTEAYE--KFGTYVPEDSIKE 86
Query: 351 VNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIK---TLYDNVDVVT 521
+ I +K L K R LN LRK LY+N+R K +EG+ ++ +++
Sbjct: 87 IQKMYIAMKSTLNFMPDK--RDLNTILRKRLGLYSNIRILKYIEGMDIPVNTFNRLNLTI 144
Query: 522 IRENTEGEY 548
IR++T +
Sbjct: 145 IRDSTPNSH 153
>UniRef50_Q2Q9C5 Cluster: Isocitrate dehydrogenase 3 gamma; n=8;
Eutheria|Rep: Isocitrate dehydrogenase 3 gamma - Homo
sapiens (Human)
Length = 88
Score = 48.0 bits (109), Expect = 3e-04
Identities = 27/73 (36%), Positives = 44/73 (60%)
Frame = +3
Query: 159 AAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQK 338
+A+Y G VT+IPG GIGPE+ + V+ +F A VP+++EEV V++ +
Sbjct: 21 SAKYG-GRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVSSNADEEDIC----N 75
Query: 339 AIDSVNANKIGLK 377
AI ++ N++ LK
Sbjct: 76 AIMAIRRNRVALK 88
>UniRef50_A0ZF75 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Nostocaceae|Rep: 3-isopropylmalate dehydrogenase -
Nodularia spumigena CCY 9414
Length = 422
Score = 47.6 bits (108), Expect = 4e-04
Identities = 56/209 (26%), Positives = 93/209 (44%), Gaps = 18/209 (8%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVA-VQKIFEAAK-----VPIEWEEVDVTAVRGPDGKFG--IPQKA 341
++ IPG GIGPE+ A +Q + + AK + +++ + TA+ KFG PQ
Sbjct: 69 RIVAIPGEGIGPEVVAASLQLLQQVAKLEGFTLQVDYGWLGTTALE----KFGTYFPQAT 124
Query: 342 IDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGI-------KTLY 500
+ N G G + V +G L LRK +D + N+RP + ++ +
Sbjct: 125 AELCN----GSDGIVFGAVTQGGL---LELRKHYDFFCNLRPIRIVDSLVNKSSLRPEKI 177
Query: 501 DNVDVVTIRENTEGEYSGIEHEIVD---GVVQSIKLITEEASTRVAEFAFQFARENKRKK 671
+D++ IRE G Y G D L + R+A A Q A++ +R K
Sbjct: 178 KGLDILVIRELVSGIYFGSAGRASDEKGAYGYHTMLYYDHEIRRLARQALQKAQQ-RRGK 236
Query: 672 VTAVHKANIMRMSDGLFLRCCRELATKYP 758
+T HK N + + + R +E A ++P
Sbjct: 237 LTVAHKEN--ALPNLPWTRLVQEEAAQFP 263
>UniRef50_Q08522 Cluster: Putative uncharacterized protein YOR135C;
n=1; Saccharomyces cerevisiae|Rep: Putative
uncharacterized protein YOR135C - Saccharomyces
cerevisiae (Baker's yeast)
Length = 113
Score = 46.8 bits (106), Expect = 8e-04
Identities = 25/43 (58%), Positives = 29/43 (67%), Gaps = 2/43 (4%)
Frame = -3
Query: 307 PLTAV--TSTSSHSIGTLAASKIF*TATVISGPIPCPGMSVTL 185
PLT + TS SHS+GT AA KIF T ISGPIP P M+ T+
Sbjct: 5 PLTKIGLTSQDSHSMGTFAALKIFFTDLEISGPIPSPSMNETV 47
>UniRef50_A1SWV5 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Psychromonas ingrahamii 37|Rep: 3-isopropylmalate
dehydrogenase - Psychromonas ingrahamii (strain 37)
Length = 368
Score = 46.4 bits (105), Expect = 0.001
Identities = 60/226 (26%), Positives = 101/226 (44%), Gaps = 28/226 (12%)
Frame = +3
Query: 189 VTLIPGHGIGPEI---TVAVQKIFEAAKVPIEWEEVDV----TAVRGPDGKFGIPQKA-- 341
+ L+ G GIGPE+ V V K+ E + +E DV A F KA
Sbjct: 6 IALLAGDGIGPEVMKEAVKVLKLIEQRNEDVNFELNDVLFGAAAYFAMGHAFPDETKAAC 65
Query: 342 --IDSVNANKIGL--KGPLMTPVG-KGYRSLNLALRKEFDLYANVRPCKSLEGI------ 488
D++ IGL + P+ + R L LR+ ++ +AN RP +G+
Sbjct: 66 DKADAILKGTIGLNHEDSKKIPIDEQPERGALLPLRRRYNTFANFRPVYLPKGLAHFSPL 125
Query: 489 --KTLYDNVDVVTIRENTEGEYSGIEHEI---VDG--VVQSIKLITEEASTRVAEFAFQF 647
+ + +D++ IRE G Y G E E+ DG V+ + E+ ++ + F+
Sbjct: 126 KASVIGEGIDIMIIRELVGGLYFG-EKEMGVNADGKRFVREVLEYDEDQIRQIVKVGFEV 184
Query: 648 ARENKRKKVT-AVHKANIMRMSDGLFLRCCRELATKYPGHQVRRAI 782
+ KRKKV +HK+N+++ S L+ E + YP +V+ +
Sbjct: 185 SM--KRKKVMHNIHKSNVLK-SSVLWNEIVEEESKNYPEVEVKNIL 227
>UniRef50_Q12592 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Ascomycota|Rep: 3-isopropylmalate dehydrogenase -
Candida maltosa (Yeast)
Length = 251
Score = 46.0 bits (104), Expect = 0.001
Identities = 52/204 (25%), Positives = 86/204 (42%), Gaps = 24/204 (11%)
Frame = +3
Query: 171 STGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGI------- 329
S + +T++PG +G EI K+ EA + ++++ G I
Sbjct: 2 SVKTKTITILPGDHVGTEIVNEAIKVLEAIEAATPYQKIHFDFKHHLIGGAAIDATGVPL 61
Query: 330 PQKAIDSVNANKIGLKGPLMTPV-GKGYRSLN---LALRKEFDLYANVRPCK----SLEG 485
P A++S + L G + P G G L +RKE +LYAN+RPC SL
Sbjct: 62 PDDALESAKNSDAVLLGAVGGPKWGTGALRPEQGLLKIRKELNLYANIRPCNFASDSLLE 121
Query: 486 IKTLYDNV----DVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEAS----TRVAEF-A 638
+ L V +++ +RE G Y G E + + TE+ + TR+ A
Sbjct: 122 LSPLRPEVVKGTNLIIVRELVGGIYFGDREEQEESEDKQTAWDTEKYTVDEVTRITRMAA 181
Query: 639 FQFARENKRKKVTAVHKANIMRMS 710
F + N + ++ KAN++ S
Sbjct: 182 FMALQHNPPLPIWSLDKANVLASS 205
>UniRef50_Q6L0K7 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Thermoplasmatales|Rep: 3-isopropylmalate dehydrogenase -
Picrophilus torridus
Length = 335
Score = 46.0 bits (104), Expect = 0.001
Identities = 37/126 (29%), Positives = 59/126 (46%), Gaps = 3/126 (2%)
Frame = +3
Query: 189 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKI 368
V LIPG GIG EI V + I + D+++ R I ++ + +
Sbjct: 4 VALIPGDGIGREIMPGVAAAISSIS-DINFVTFDISSERYIKTGIIIKDDELEELKNYRA 62
Query: 369 GLKGPLMTP-VGKGY--RSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTE 539
L G + P V G + + L LR+E +LY N+RP +S + D + + +RENT+
Sbjct: 63 ILFGAIGDPRVRPGIMEQGVILRLRRELELYMNIRPVRSFD------DKIKITILRENTQ 116
Query: 540 GEYSGI 557
Y+ I
Sbjct: 117 DFYTDI 122
>UniRef50_Q3ZXI7 Cluster: 3-isopropylmalate dehydrogenase; n=66;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Dehalococcoides sp. (strain CBDB1)
Length = 365
Score = 45.6 bits (103), Expect = 0.002
Identities = 42/132 (31%), Positives = 66/132 (50%), Gaps = 12/132 (9%)
Frame = +3
Query: 423 LALRKEFDLYANVRPCK---SLEG---IKT-LYDNVDVVTIRENTEGEYSGIEHE---IV 572
LALRK L+AN+RP K SL IK + D + IRE T G Y +
Sbjct: 93 LALRKGLGLFANIRPVKVAPSLVNSTPIKAEIVKGTDFIFIRELTGGVYFAKPKKRWTTP 152
Query: 573 DGVVQSIKLIT--EEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSDGLFLRCCRELA 746
G+ ++ +T E R+ F+ A+ N++KK+ +V KAN++ +S L+ + E+A
Sbjct: 153 AGIRKATDSMTYSENEIERIVRVGFELAK-NRKKKLVSVDKANVL-LSSRLWRQIVIEVA 210
Query: 747 TKYPGHQVRRAI 782
YP +V +
Sbjct: 211 KDYPEVKVEHVL 222
>UniRef50_Q5IWY1 Cluster: Plastid 3-isopropylmalate dehydrogenase;
n=1; Prototheca wickerhamii|Rep: Plastid
3-isopropylmalate dehydrogenase - Prototheca wickerhamii
Length = 211
Score = 42.7 bits (96), Expect = 0.012
Identities = 42/153 (27%), Positives = 63/153 (41%), Gaps = 18/153 (11%)
Frame = +3
Query: 150 RAGAAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAA-----------KVPIEWEEVDVT 296
RA A + +VT++PG GIGPEIT + EAA + I D T
Sbjct: 28 RARPALATCAAHRVTVLPGDGIGPEITAVTLSVLEAAGKAEGESFTFTEALIGGAAYDAT 87
Query: 297 AVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKS 476
PD + + + A G K + V K L L LR + +AN+RP
Sbjct: 88 GDPYPDATYRACADSDAVLLAAIGGYKWDALPSVSKPETGL-LRLRSSLNAFANLRPATV 146
Query: 477 LEGI-------KTLYDNVDVVTIRENTEGEYSG 554
+ + + + + VD++ +RE G Y G
Sbjct: 147 IPELADASSLKREVLEGVDLLIVRELVGGIYFG 179
>UniRef50_Q5A9E0 Cluster: Putative uncharacterized protein; n=1;
Candida albicans|Rep: Putative uncharacterized protein -
Candida albicans (Yeast)
Length = 150
Score = 42.3 bits (95), Expect = 0.016
Identities = 45/124 (36%), Positives = 55/124 (44%), Gaps = 7/124 (5%)
Frame = -3
Query: 547 YSPSVFSLIVTTSTLSYSVLIPSKLLQGLTLAYKSNSFLRAKLSDL*P--LPTGVIRGPF 374
Y SVFS +T ST + IPS L G TLAYK N FL A + + P L G P
Sbjct: 2 YKSSVFSRTITIST---GLPIPSTDLTGSTLAYKPNFFLNATIGEEYPATLVVGDETAPN 58
Query: 373 K-PILLAFTESIAFWG--IPNLPSGPLTAVTSTSSHSIGTLAA--SKIF*TATVISGPIP 209
P F S G +P + A T+S+ LA SK A + S PIP
Sbjct: 59 NAPSHSFFKTSTVSSGKAVPVFLNNSKPASKLTNSNCKSCLAGKFSKTALPAGITSRPIP 118
Query: 208 CPGM 197
PG+
Sbjct: 119 SPGI 122
>UniRef50_A1WV93 Cluster: 3-isopropylmalate dehydrogenase; n=7;
Gammaproteobacteria|Rep: 3-isopropylmalate dehydrogenase
- Halorhodospira halophila (strain DSM 244 / SL1)
(Ectothiorhodospirahalophila (strain DSM 244 / SL1))
Length = 389
Score = 41.9 bits (94), Expect = 0.022
Identities = 57/218 (26%), Positives = 85/218 (38%), Gaps = 26/218 (11%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAAKVP------IEWEEVDVTAVRGP--DGKFGIPQKA 341
+V ++PG GIGPE+ A + EA P + W G +
Sbjct: 9 QVAVMPGDGIGPEVMAATRHALEALPGPALVLTELGWPAHAWHRDHGEMMPADWRGQLAG 68
Query: 342 IDSVNANKIGLKGP------LMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKT-LY 500
D++ +G GP P G L L LRK DL+A RP L G L
Sbjct: 69 YDALLLGALGDPGPSHDAQRYCLPDGVSLAPL-LQLRKGLDLWACERPAVPLAGAPMPLS 127
Query: 501 D----NVDVVTIRENTEGEYSGIEHEIVDG----VVQSIKLITEEASTRVAEFAFQFA-- 650
D + D++ IREN+EGEY + G +++ T + R+ AF+ A
Sbjct: 128 DPRALHTDLLVIRENSEGEYVDQGGRLAAGTPRETATQLEVFTRAGTERIIRHAFERAAR 187
Query: 651 -RENKRKKVTAVHKANIMRMSDGLFLRCCRELATKYPG 761
E +R+ + A A +D + A +Y G
Sbjct: 188 RAEERRQGLRAPRYAAADGAADAAVCVVTKRNAVQYAG 225
>UniRef50_Q6B458 Cluster: 3-isopropylmalate dehydrogenase; n=30;
Ascomycota|Rep: 3-isopropylmalate dehydrogenase -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 382
Score = 41.9 bits (94), Expect = 0.022
Identities = 47/200 (23%), Positives = 83/200 (41%), Gaps = 24/200 (12%)
Frame = +3
Query: 183 RKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGI-------PQKA 341
+ +T++PG +G E+ K+ +A + + + + G I P ++
Sbjct: 15 KTITVLPGDHVGEEVCNEAIKVLQAIEDATPYRNIKFNLQKHLIGGAAIDATGTPLPDES 74
Query: 342 IDSVNANKIGLKGPLMTPV-GKGYRSLN---LALRKEFDLYANVRPCK-------SLEGI 488
+++ + L G + P G G L +RKE +LYAN+RPC L +
Sbjct: 75 LEAAKNSDAVLLGAVGGPKWGTGSVRPEQGLLKIRKELNLYANLRPCNFASDSLLELSPL 134
Query: 489 KT-LYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEAS----TRVAEF-AFQFA 650
K+ + D +RE G Y G E + + TE+ S TR+ AF
Sbjct: 135 KSEIVKGTDFTVVRELVGGIYFGERQEQAESEDKQTAWDTEKYSTEEVTRITRMAAFMAL 194
Query: 651 RENKRKKVTAVHKANIMRMS 710
+ N + ++ KAN++ S
Sbjct: 195 QHNPPLPIWSLDKANVLASS 214
>UniRef50_O59930 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Dikarya|Rep: 3-isopropylmalate dehydrogenase -
Phanerochaete chrysosporium (White-rot fungus)
(Sporotrichumpruinosum)
Length = 380
Score = 41.5 bits (93), Expect = 0.028
Identities = 51/198 (25%), Positives = 76/198 (38%), Gaps = 23/198 (11%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTA--VRGPD-GKFGIPQKAIDSVN 356
K+ ++PG GIGPE+ ++ E E+ + G K G P A ++
Sbjct: 7 KIVILPGDGIGPEVVAEATRVLEVVSASSSDVEIKLETHDFGGCSIDKHGEPLTAA-TLE 65
Query: 357 ANKIG---LKGPLMTP---VGKGYRSLN--LALRKEFDLYANVRPCKSLEGIKTLYD--- 503
A K+ L G + P V R LALRK LYAN+RP Y
Sbjct: 66 ACKLADAILLGAIGGPKWGVNSKVRPEQALLALRKALGLYANIRPANFASDSLLAYSPLK 125
Query: 504 -----NVDVVTIRENTEGEYSGIEHEI----VDGVVQSIKLITEEASTRVAEFAFQFARE 656
VD++ IRE G Y G E+ + + + R+ Q A
Sbjct: 126 PSVARGVDIIVIRELIGGAYFGERKELGARAQEDAAWDTMIYSVPEVQRITRSRRQVASP 185
Query: 657 NKRKKVTAVHKANIMRMS 710
+ V ++ KAN++ S
Sbjct: 186 DPPLPVHSIDKANVLASS 203
>UniRef50_P41566 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 106
Score = 39.1 bits (87), Expect = 0.15
Identities = 19/47 (40%), Positives = 31/47 (65%)
Frame = +3
Query: 159 AAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTA 299
+A+Y G+ VT+ PG G GPE+ + V +A VP+++EEV V++
Sbjct: 9 SAKYG-GILTVTMSPGDGDGPELMLTVXXXXXSACVPVDFEEVVVSS 54
>UniRef50_A0Q405 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Francisella tularensis|Rep: 3-isopropylmalate
dehydrogenase - Francisella tularensis subsp. novicida
(strain U112)
Length = 359
Score = 38.3 bits (85), Expect = 0.27
Identities = 51/220 (23%), Positives = 90/220 (40%), Gaps = 24/220 (10%)
Frame = +3
Query: 183 RKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDG----KFGIPQKAIDS 350
+ + ++ G GIGPE+ + K+ + + + A+ G K P++ ++
Sbjct: 3 KNIAILAGDGIGPEVMESAIKVLDTIAKKYNHKFNYIEALIGGAAYVKYKSHCPEETLEI 62
Query: 351 VNANKIGLKGPLMTPVG-------KGYRSLN-LALRKEFDLYANVRPCKSLEGIK----- 491
+ L G + PV +G + + LALRK F N+RP K ++
Sbjct: 63 CKNSDAILFGSVGGPVEAQNEEKWQGCEANSILALRKHFGFNINIRPSKIFPALREACPL 122
Query: 492 ---TLYDNVDVVTIRENTEGEYSGIEHEIVD--GV--VQSIKLITEEASTRVAEFAFQFA 650
+ + D+ RE + Y G D GV I E + AF+ A
Sbjct: 123 KDSRIANGADIEIFRELSRDIYFGEHRTFTDEHGVKCATDIAEYDEHTIRNIVVQAFERA 182
Query: 651 RENKRKKVTAVHKANIMRMSDGLFLRCCRELATKYPGHQV 770
+ + ++T+V KAN++ S L+ E+A YP +V
Sbjct: 183 TQ-RSNRLTSVDKANVLDTS-RLWRNIVNEVAKDYPSVKV 220
>UniRef50_Q4P2R4 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 363
Score = 38.3 bits (85), Expect = 0.27
Identities = 40/145 (27%), Positives = 62/145 (42%), Gaps = 18/145 (12%)
Frame = +3
Query: 186 KVTLIPGHGIGPEITVAVQKIFEAAK----VPIEWEEVDVTAVRGPDGKFGIPQKAIDSV 353
KV ++ G IGPE+ V +F+ + + +E E + I + +
Sbjct: 14 KVMVLQGDHIGPEVMAEVLPLFDVIQSHFGIKVETFERLIGGSCLDQHDCPIQESTLQEA 73
Query: 354 NANKIGLKGPLMTP---VGKGYRSLN---LALRKEFDLYANVRPCK-------SLEGIKT 494
+ L G + P VG R L +RK +LYANVRP K L +K
Sbjct: 74 SECHAVLLGSVGGPKWDVGDSSRRPETGILRMRKHLNLYANVRPAKIISERQLELSSLKE 133
Query: 495 -LYDNVDVVTIRENTEGEYSGIEHE 566
+ V+++T+REN G Y G + E
Sbjct: 134 HVVRGVNIITLRENAGGIYFGRKQE 158
>UniRef50_A2E7S3 Cluster: Putative uncharacterized protein; n=1;
Trichomonas vaginalis G3|Rep: Putative uncharacterized
protein - Trichomonas vaginalis G3
Length = 1175
Score = 36.3 bits (80), Expect = 1.1
Identities = 20/75 (26%), Positives = 40/75 (53%), Gaps = 3/75 (4%)
Frame = +3
Query: 360 NKIGLKGPLMTPVGKGYRSLNLALRKEFDL---YANVRPCKSLEGIKTLYDNVDVVTIRE 530
NK+ L G + V KG+ + L++ K+ + Y +V + L + T N+ +++ +
Sbjct: 533 NKLNLNGSALIAVVKGFLNGELSMWKKISMDTNYMHVSDLQLLTALFTRMPNLRELSLSD 592
Query: 531 NTEGEYSGIEHEIVD 575
N + +GIE+E+ D
Sbjct: 593 NFDASMAGIEYELPD 607
>UniRef50_Q8WWQ4 Cluster: Mucin 5; n=5; Catarrhini|Rep: Mucin 5 - Homo
sapiens (Human)
Length = 1349
Score = 36.3 bits (80), Expect = 1.1
Identities = 39/157 (24%), Positives = 63/157 (40%), Gaps = 1/157 (0%)
Frame = -3
Query: 655 SLANW-KANSATLVLASSVISLMDCTTPSTISCSIPEYSPSVFSLIVTTSTLSYSVLIPS 479
S ++W K+ + TLV S+ + TT + + +IP +PS S T++T + + S
Sbjct: 1056 STSSWQKSRTTTLVTTSTTSTPQTSTTSAPTTSTIPASTPSTTSAPTTSTTSAPTTSTTS 1115
Query: 478 KLLQGLTLAYKSNSFLRAKLSDL*PLPTGVIRGPFKPILLAFTESIAFWGIPNLPSGPLT 299
T +++ L S T P + A T S + S P +
Sbjct: 1116 APTHRTTSGPTTSTTLAPTTSTTSAPTTSTNSAPTTSTISASTTSTISAPTTSTISSPTS 1175
Query: 298 AVTSTSSHSIGTLAASKIF*TATVISGPIPCPGMSVT 188
+ TST S + A S T+ + P P P S T
Sbjct: 1176 STTSTPQTSKTSAATSST--TSGSGTTPSPVPTTSTT 1210
>UniRef50_O59395 Cluster: Putative uncharacterized protein PH1723;
n=1; Pyrococcus horikoshii|Rep: Putative uncharacterized
protein PH1723 - Pyrococcus horikoshii
Length = 122
Score = 36.3 bits (80), Expect = 1.1
Identities = 31/78 (39%), Positives = 40/78 (51%)
Frame = -3
Query: 664 LLFSLANWKANSATLVLASSVISLMDCTTPSTISCSIPEYSPSVFSLIVTTSTLSYSVLI 485
+L S A++ AN A L VI L T + + S P YSPS+FSL + S L+ I
Sbjct: 1 MLLSFASFTANLAILSAPFLVIILKSTTLLLSYAPS-PLYSPSLFSLTIIISFLNLKFGI 59
Query: 484 PSKLLQGLTLAYKSNSFL 431
L AYKS+SFL
Sbjct: 60 I------LRFAYKSSSFL 71
>UniRef50_P34738 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Sordariomycetes|Rep: 3-isopropylmalate dehydrogenase -
Neurospora crassa
Length = 368
Score = 35.9 bits (79), Expect = 1.4
Identities = 34/106 (32%), Positives = 46/106 (43%), Gaps = 10/106 (9%)
Frame = +3
Query: 423 LALRKEFDLYANVRPC----KSLEGIKTLYDNV----DVVTIRENTEGEYSGIEHE-IVD 575
L LRKE Y N+RPC +SL L V D + +RE T G Y G E
Sbjct: 95 LKLRKELGTYGNLRPCNFASESLVDSSPLKAEVCRGTDFIVVRELTGGIYFGDRTEDDGS 154
Query: 576 GVVQSIKLITEEASTRVAEFA-FQFARENKRKKVTAVHKANIMRMS 710
G + + R+A A F +N KV ++ KAN++ S
Sbjct: 155 GYACDTEPYSRAEIVRIARLAGFLALAKNPPAKVWSLDKANVLATS 200
>UniRef50_Q6AGK4 Cluster: Putative uncharacterized protein; n=1;
Leifsonia xyli subsp. xyli|Rep: Putative uncharacterized
protein - Leifsonia xyli subsp. xyli
Length = 257
Score = 35.1 bits (77), Expect = 2.5
Identities = 31/123 (25%), Positives = 58/123 (47%), Gaps = 4/123 (3%)
Frame = -3
Query: 634 NSATLVLASSVISLMDCTTPSTISCSIPEYSPSVFSLIVTTSTLSYS--VLIPSKLLQGL 461
NSA V A++ + ++ P ++ + P SP+ L++ STL+ S +++ L L
Sbjct: 48 NSARTVAAAAAMGVLVSGFPLLLTVTSPHASPTALGLLLLVSTLTRSPLIVVAMALQSYL 107
Query: 460 TLAYKSNSFLRAKLSDL--*PLPTGVIRGPFKPILLAFTESIAFWGIPNLPSGPLTAVTS 287
+ ++ + R LS L L G + G +L S+ F G P P+ + + +
Sbjct: 108 IVFFRQSPNPRRALSALLGLALAAGGVLGVLGLLLGEAVFSLLFPGQPVPPAWLIAVLVA 167
Query: 286 TSS 278
TS+
Sbjct: 168 TSA 170
>UniRef50_Q6JAD6 Cluster: Putative uncharacterized protein; n=1; Zea
mays|Rep: Putative uncharacterized protein - Zea mays
(Maize)
Length = 725
Score = 35.1 bits (77), Expect = 2.5
Identities = 18/62 (29%), Positives = 32/62 (51%)
Frame = -3
Query: 388 IRGPFKPILLAFTESIAFWGIPNLPSGPLTAVTSTSSHSIGTLAASKIF*TATVISGPIP 209
+ P +P+ LAFT + P P P +AV ST++ ++ A++ + A +S +P
Sbjct: 627 VTSPLRPVTLAFTSPVLSSVCPQPPVPPASAV-STTAVAVSVTASAPVAPAALPVSESVP 685
Query: 208 CP 203
P
Sbjct: 686 AP 687
>UniRef50_A5FB87 Cluster: Von Willebrand factor, type A precursor;
n=1; Flavobacterium johnsoniae UW101|Rep: Von Willebrand
factor, type A precursor - Flavobacterium johnsoniae
UW101
Length = 2588
Score = 34.3 bits (75), Expect = 4.3
Identities = 18/60 (30%), Positives = 29/60 (48%)
Frame = -3
Query: 649 ANWKANSATLVLASSVISLMDCTTPSTISCSIPEYSPSVFSLIVTTSTLSYSVLIPSKLL 470
AN A + TL AS V +CT +T+ + PEY+ + I+ T + +P L+
Sbjct: 1646 ANLPAGTYTLTAASPVSETQNCTASTTVVITQPEYTVKISGHIINVDTHTGIANVPVTLI 1705
>UniRef50_A3DDD4 Cluster: Phage integrase; n=5; Clostridia|Rep:
Phage integrase - Clostridium thermocellum (strain ATCC
27405 / DSM 1237)
Length = 330
Score = 34.3 bits (75), Expect = 4.3
Identities = 19/54 (35%), Positives = 27/54 (50%), Gaps = 4/54 (7%)
Frame = +3
Query: 351 VNANKIGLKGPLMTPVGKGYRS----LNLALRKEFDLYANVRPCKSLEGIKTLY 500
VN N +K ++T VGKG + LN A +K D Y VRP ++ L+
Sbjct: 177 VNINLSNIKNDVLTVVGKGNKERTIYLNAACKKALDAYLKVRPVDGVKDKNALF 230
>UniRef50_P56472 Cluster: Isocitrate dehydrogenase [NAD] subunit
beta, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit beta,
mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase)
(NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 103
Score = 34.3 bits (75), Expect = 4.3
Identities = 13/29 (44%), Positives = 19/29 (65%)
Frame = +3
Query: 672 VTAVHKANIMRMSDGLFLRCCRELATKYP 758
+ AV +++ DGLFL+CC E+A YP
Sbjct: 30 MAAVGVIECLKLGDGLFLQCCEEVAELYP 58
>UniRef50_A2TU03 Cluster: Ribonuclease HII; n=1; Dokdonia
donghaensis MED134|Rep: Ribonuclease HII - Dokdonia
donghaensis MED134
Length = 818
Score = 33.9 bits (74), Expect = 5.7
Identities = 22/64 (34%), Positives = 35/64 (54%), Gaps = 4/64 (6%)
Frame = -3
Query: 622 LVLASSVISLMDCTTPSTISCSIPEYSPSVFSLIVTTSTLS--YSVLIPSKLLQ--GLTL 455
L L++ V+ L CTT + S S+ +Y P S++V T+ L S L+ + +Q G T
Sbjct: 5 LYLSAVVVLLASCTTSTKNSSSLTKYIPRKASVVVKTTDLKDFKSALVNNDFIQELGTTS 64
Query: 454 AYKS 443
YK+
Sbjct: 65 LYKT 68
>UniRef50_Q7RB56 Cluster: Fulmal1; n=2; Plasmodium (Vinckeia)|Rep:
Fulmal1 - Plasmodium yoelii yoelii
Length = 835
Score = 33.9 bits (74), Expect = 5.7
Identities = 11/22 (50%), Positives = 16/22 (72%)
Frame = +2
Query: 95 CENS*NGCKNNQENCASDQSRR 160
C+N NGCKN + NC +DQ+ +
Sbjct: 213 CKNGENGCKNGEHNCKNDQNSK 234
>UniRef50_A7SWW3 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 441
Score = 33.9 bits (74), Expect = 5.7
Identities = 24/65 (36%), Positives = 35/65 (53%)
Frame = -3
Query: 631 SATLVLASSVISLMDCTTPSTISCSIPEYSPSVFSLIVTTSTLSYSVLIPSKLLQGLTLA 452
+A ++L SSVI + P++ SIP + + IVT +TL Y L+P L+ LT A
Sbjct: 307 AALIILFSSVIYYSESVDPNSNFTSIPA---TFWYTIVTMTTLGYGDLVPESLVGRLTGA 363
Query: 451 YKSNS 437
S S
Sbjct: 364 LCSLS 368
>UniRef50_Q2UNH1 Cluster: Predicted protein; n=2;
Trichocomaceae|Rep: Predicted protein - Aspergillus
oryzae
Length = 238
Score = 33.9 bits (74), Expect = 5.7
Identities = 32/145 (22%), Positives = 63/145 (43%), Gaps = 8/145 (5%)
Frame = +3
Query: 267 PIEWEEVDVTAVRGPDGKFGIPQKAID--SVNANKIGLKGPLMTPVGKGYRSLNL-ALRK 437
P+E VD++ V GP G P+ +D S + P ++P + S NL A R
Sbjct: 94 PVEVSSVDISPVEGPSSP-GAPEMTMDPSSPGGFSVSPVFPPLSPAVESNGSRNLDAERT 152
Query: 438 EFDLYANVRPCKSLEGIKT-LYDNVDV----VTIRENTEGEYSGIEHEIVDGVVQSIKLI 602
FD+ + P S +++ L D D+ + + +N+ +G +H I + +
Sbjct: 153 SFDVGSADTPTWSDASLRSYLDDESDIRDLFIIVHDNSNVPPAGPDHPITGSLFKEESKR 212
Query: 603 TEEASTRVAEFAFQFARENKRKKVT 677
+E ++++ + RK ++
Sbjct: 213 LKEMNSQLDSMLADWVGRKMRKSIS 237
>UniRef50_Q8R6G0 Cluster: Glycosyl transferase; n=1; Fusobacterium
nucleatum subsp. nucleatum|Rep: Glycosyl transferase -
Fusobacterium nucleatum subsp. nucleatum
Length = 268
Score = 33.5 bits (73), Expect = 7.5
Identities = 22/83 (26%), Positives = 44/83 (53%), Gaps = 1/83 (1%)
Frame = +3
Query: 471 KSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSI-KLITEEASTRVAEFAFQF 647
K LE +KT +DNV +++++EN +G+ + +++ + ++ +++ ST+ F Q
Sbjct: 49 KVLEKVKTKHDNVKIISLKEN-KGQSEALNQGLLNCSYDLVARMDSDDISTK-KRFELQI 106
Query: 648 ARENKRKKVTAVHKANIMRMSDG 716
NK + AV + SDG
Sbjct: 107 DAFNKDYSIDAVSGTSEDFSSDG 129
>UniRef50_Q62HK9 Cluster: Putative uncharacterized protein; n=15;
Burkholderia|Rep: Putative uncharacterized protein -
Burkholderia mallei (Pseudomonas mallei)
Length = 248
Score = 33.5 bits (73), Expect = 7.5
Identities = 17/51 (33%), Positives = 24/51 (47%)
Frame = +3
Query: 15 RSHYREFLKILPPPPPFTASYRSSSQFAKILEMAARIIRKIVPATRAGAAQ 167
RSH R K +PPPP + +RSS+ +++ RI G AQ
Sbjct: 135 RSHLRRVKKPVPPPPTWDGRWRSSAGARRLIVHGERISYSFAGGGGTGGAQ 185
>UniRef50_Q9RA19 Cluster: ORF10; n=1; Moritella marina|Rep: ORF10 -
Vibrio marinus (Moritella marina)
Length = 2011
Score = 33.5 bits (73), Expect = 7.5
Identities = 17/48 (35%), Positives = 26/48 (54%), Gaps = 2/48 (4%)
Frame = +3
Query: 495 LYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEE--ASTRVAE 632
+YD D+V E G+ G E+ I+DG + ++L T + TRV E
Sbjct: 1156 IYDQADLVEFAEGDIGKVFGAEYNIIDGYSRRVRLPTSDYLLVTRVTE 1203
>UniRef50_Q1QFN8 Cluster: Glycosidase, PH1107-related; n=2;
Bradyrhizobiaceae|Rep: Glycosidase, PH1107-related -
Nitrobacter hamburgensis (strain X14 / DSM 10229)
Length = 373
Score = 33.5 bits (73), Expect = 7.5
Identities = 21/63 (33%), Positives = 32/63 (50%), Gaps = 3/63 (4%)
Frame = +3
Query: 267 PIEWEEV-DVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGK--GYRSLNLALRK 437
P+E E V + A RGPDG+ + + + N ++IG+ L +G G L +AL
Sbjct: 20 PLEAEGVLNPAAARGPDGQLYLFPRLVARGNHSRIGIARVLFNEIGDPVGVERLGIALEP 79
Query: 438 EFD 446
E D
Sbjct: 80 EMD 82
>UniRef50_Q2VF40 Cluster: Isocitrate dehydrogenase 3 gamma subunit;
n=1; Pan troglodytes|Rep: Isocitrate dehydrogenase 3
gamma subunit - Pan troglodytes (Chimpanzee)
Length = 165
Score = 33.5 bits (73), Expect = 7.5
Identities = 15/31 (48%), Positives = 22/31 (70%)
Frame = +3
Query: 159 AAQYSTGVRKVTLIPGHGIGPEITVAVQKIF 251
+A+Y G VT+IPG GIGPE+ + V+ +F
Sbjct: 106 SAKYG-GRHTVTMIPGDGIGPELMLHVKSVF 135
>UniRef50_Q8D4B1 Cluster: Putative uncharacterized protein; n=2;
Vibrio vulnificus|Rep: Putative uncharacterized protein
- Vibrio vulnificus
Length = 1222
Score = 33.1 bits (72), Expect = 10.0
Identities = 15/58 (25%), Positives = 35/58 (60%)
Frame = +3
Query: 501 DNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKV 674
D + VT+ + T+GE + + ++ VV K+ ++A+T V ++A++ E +R+++
Sbjct: 527 DTIQYVTVTQGTDGELASVTTQLDQFVVNGFKI--DDATTHVKDYAYR-GVEKRREQI 581
>UniRef50_Q5NXI3 Cluster: Putative uncharacterized protein; n=1;
Azoarcus sp. EbN1|Rep: Putative uncharacterized protein
- Azoarcus sp. (strain EbN1) (Aromatoleum aromaticum
(strain EbN1))
Length = 1082
Score = 33.1 bits (72), Expect = 10.0
Identities = 17/61 (27%), Positives = 31/61 (50%)
Frame = +3
Query: 15 RSHYREFLKILPPPPPFTASYRSSSQFAKILEMAARIIRKIVPATRAGAAQYSTGVRKVT 194
R ++ E L +P P + +YR+ + ++L+ + + P+ AG Y+TG VT
Sbjct: 314 RLNWIETLAPIPAPGTLSVAYRAQDNWYELLDNGSGQLVGSDPSIGAGTINYTTGAMSVT 373
Query: 195 L 197
L
Sbjct: 374 L 374
>UniRef50_A4M233 Cluster: Putative uncharacterized protein
precursor; n=2; Geobacter|Rep: Putative uncharacterized
protein precursor - Geobacter bemidjiensis Bem
Length = 166
Score = 33.1 bits (72), Expect = 10.0
Identities = 12/18 (66%), Positives = 14/18 (77%)
Frame = +3
Query: 21 HYREFLKILPPPPPFTAS 74
H+REF +LPPPPP T S
Sbjct: 35 HFREFQTVLPPPPPGTVS 52
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 863,882,079
Number of Sequences: 1657284
Number of extensions: 17521357
Number of successful extensions: 61946
Number of sequences better than 10.0: 142
Number of HSP's better than 10.0 without gapping: 58161
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 61661
length of database: 575,637,011
effective HSP length: 100
effective length of database: 409,908,611
effective search space used: 81981722200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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