Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fdpeP04_F_M01
(887 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P07864 Cluster: L-lactate dehydrogenase C chain; n=371;... 255 1e-66
UniRef50_Q4SRH5 Cluster: L-lactate dehydrogenase; n=4; Euteleost... 247 3e-64
UniRef50_UPI0000519EC7 Cluster: PREDICTED: similar to Ecdysone-i... 221 1e-56
UniRef50_Q7NG49 Cluster: L-lactate dehydrogenase; n=4; Cyanobact... 194 2e-48
UniRef50_UPI0000DB7268 Cluster: PREDICTED: similar to L-lactate ... 183 6e-45
UniRef50_Q8XP62 Cluster: L-lactate dehydrogenase; n=11; Clostrid... 182 8e-45
UniRef50_Q892U0 Cluster: L-lactate dehydrogenase; n=12; Bacteria... 178 1e-43
UniRef50_P22988 Cluster: L-lactate dehydrogenase A; n=19; Magnol... 175 9e-43
UniRef50_Q1IRL5 Cluster: L-lactate dehydrogenase; n=6; Bacteria|... 174 3e-42
UniRef50_Q6NPB9 Cluster: AT22132p; n=2; Drosophila melanogaster|... 168 2e-40
UniRef50_Q81K80 Cluster: L-lactate dehydrogenase 2; n=12; Firmic... 167 2e-40
UniRef50_A4QXM2 Cluster: Putative uncharacterized protein; n=1; ... 163 4e-39
UniRef50_P19869 Cluster: L-lactate dehydrogenase 2; n=17; Bacter... 163 7e-39
UniRef50_P0A3M9 Cluster: L-lactate dehydrogenase; n=140; Bacteri... 162 1e-38
UniRef50_A5KJY5 Cluster: Putative uncharacterized protein; n=2; ... 161 3e-38
UniRef50_P20619 Cluster: L-lactate dehydrogenase X; n=14; Bacill... 160 4e-38
UniRef50_A3DCA4 Cluster: L-lactate dehydrogenase precursor; n=2;... 159 9e-38
UniRef50_O51114 Cluster: L-lactate dehydrogenase; n=4; Borrelia ... 156 8e-37
UniRef50_Q9P7P7 Cluster: Probable L-lactate dehydrogenase; n=2; ... 155 2e-36
UniRef50_A6NLX8 Cluster: L-lactate dehydrogenase; n=4; Eutheria|... 154 3e-36
UniRef50_Q838C9 Cluster: L-lactate dehydrogenase 2; n=9; Bacilli... 152 1e-35
UniRef50_Q4JY42 Cluster: L-lactate dehydrogenase; n=1; Corynebac... 151 2e-35
UniRef50_A3JXA9 Cluster: L-lactate dehydrogenase; n=1; Sagittula... 150 4e-35
UniRef50_P16115 Cluster: L-lactate dehydrogenase; n=4; Thermotog... 150 5e-35
UniRef50_UPI00015B6427 Cluster: PREDICTED: similar to lactate de... 149 9e-35
UniRef50_Q2S4R2 Cluster: L-lactate dehydrogenase; n=1; Salinibac... 149 1e-34
UniRef50_A1U9V0 Cluster: Lactate/malate dehydrogenase; n=6; Acti... 145 1e-33
UniRef50_P62051 Cluster: L-lactate dehydrogenase; n=2; Desulfovi... 141 2e-32
UniRef50_P50933 Cluster: L-lactate dehydrogenase; n=7; Bacteria|... 140 6e-32
UniRef50_P62056 Cluster: L-lactate dehydrogenase; n=2; Bacteria|... 138 2e-31
UniRef50_Q6A9C3 Cluster: L-lactate dehydrogenase; n=2; Propionib... 137 3e-31
UniRef50_Q8ELF0 Cluster: L-lactate dehydrogenase; n=5; Bacillace... 137 3e-31
UniRef50_UPI0000DB7267 Cluster: PREDICTED: similar to Ecdysone-i... 133 7e-30
UniRef50_Q98PG4 Cluster: L-lactate dehydrogenase; n=1; Mycoplasm... 132 9e-30
UniRef50_A4L2P0 Cluster: L-lactate dehydrogenase; n=4; Lactobaci... 132 1e-29
UniRef50_Q81XJ7 Cluster: L-lactate dehydrogenase 3; n=13; Firmic... 132 2e-29
UniRef50_A6M0Q2 Cluster: L-lactate dehydrogenase; n=1; Clostridi... 130 3e-29
UniRef50_Q97DC6 Cluster: L-lactate dehydrogenase 2; n=1; Clostri... 129 1e-28
UniRef50_P59390 Cluster: L-lactate dehydrogenase 2; n=8; Lactoba... 128 2e-28
UniRef50_UPI000038D9FF Cluster: COG0039: Malate/lactate dehydrog... 128 2e-28
UniRef50_Q0UX88 Cluster: L-lactate dehydrogenase; n=2; Phaeospha... 127 4e-28
UniRef50_A2SSY4 Cluster: L-lactate dehydrogenase; n=3; Methanomi... 126 6e-28
UniRef50_Q9P4B6 Cluster: L-lactate dehydrogenase A; n=48; Rhizop... 126 8e-28
UniRef50_Q03BE6 Cluster: L-lactate dehydrogenase; n=1; Lactobaci... 126 1e-27
UniRef50_O67655 Cluster: Malate dehydrogenase 1; n=3; Bacteria|R... 125 2e-27
UniRef50_Q8TWG5 Cluster: Malate dehydrogenase; n=2; Euryarchaeot... 123 7e-27
UniRef50_Q6KIP9 Cluster: L-lactate dehydrogenase; n=1; Mycoplasm... 122 9e-27
UniRef50_Q8YJE7 Cluster: Malate dehydrogenase; n=98; Bacteria|Re... 121 2e-26
UniRef50_A3EWH3 Cluster: Malate/lactate dehydrogenase; n=1; Lept... 121 3e-26
UniRef50_Q6F0L9 Cluster: L-lactate dehydrogenase; n=6; Mollicute... 120 5e-26
UniRef50_Q18WQ6 Cluster: Malate dehydrogenase, NAD-dependent; n=... 120 7e-26
UniRef50_Q8ZVB2 Cluster: Malate dehydrogenase; n=14; Thermoprote... 120 7e-26
UniRef50_Q4L941 Cluster: L-lactate dehydrogenase; n=1; Staphyloc... 119 1e-25
UniRef50_P47698 Cluster: L-lactate dehydrogenase; n=2; Mycoplasm... 119 1e-25
UniRef50_A7I5J9 Cluster: L-lactate dehydrogenase precursor; n=1;... 118 2e-25
UniRef50_Q64P62 Cluster: Malate dehydrogenase; n=28; Bacteroidet... 118 2e-25
UniRef50_A1HSK3 Cluster: Lactate/malate dehydrogenase; n=1; Ther... 118 3e-25
UniRef50_Q979N9 Cluster: Malate dehydrogenase; n=4; Thermoplasma... 117 3e-25
UniRef50_Q92BI0 Cluster: L-lactate dehydrogenase 2; n=18; Bacter... 116 6e-25
UniRef50_Q3ZZJ7 Cluster: Malate dehydrogenase; n=5; cellular org... 116 1e-24
UniRef50_Q1FID3 Cluster: L-lactate dehydrogenase precursor; n=1;... 114 3e-24
UniRef50_A4A2L6 Cluster: L-lactate dehydrogenase; n=4; Bacteria|... 114 3e-24
UniRef50_A7DRG3 Cluster: Lactate/malate dehydrogenase; n=1; Cand... 111 2e-23
UniRef50_Q9EVR0 Cluster: L-lactate dehydrogenase; n=1; Selenomon... 111 2e-23
UniRef50_A0RXX8 Cluster: Malate/L-lactate dehydrogenase; n=1; Ce... 110 5e-23
UniRef50_Q9CGG8 Cluster: L-lactate dehydrogenase 3; n=3; Lactoco... 110 5e-23
UniRef50_A4BB89 Cluster: Lactate dehydrogenase; n=2; Gammaproteo... 109 7e-23
UniRef50_Q8IX04 Cluster: Ubiquitin-conjugating enzyme E2 variant... 109 7e-23
UniRef50_Q07841 Cluster: Malate dehydrogenase; n=7; Halobacteria... 109 9e-23
UniRef50_O67581 Cluster: Malate dehydrogenase 2; n=1; Aquifex ae... 109 9e-23
UniRef50_O08349 Cluster: Malate dehydrogenase; n=1; Archaeoglobu... 109 1e-22
UniRef50_Q185V1 Cluster: L-lactate dehydrogenase; n=3; Clostridi... 108 2e-22
UniRef50_A0RPE9 Cluster: Malate dehydrogenase; n=1; Campylobacte... 108 2e-22
UniRef50_A7U552 Cluster: Mitochondrial malate-dehydrogenase; n=2... 108 2e-22
UniRef50_A2UB98 Cluster: Lactate/malate dehydrogenase precursor;... 108 2e-22
UniRef50_A1C5Q5 Cluster: L-lactate dehydrogenase; n=4; Pezizomyc... 107 3e-22
UniRef50_Q7NHJ3 Cluster: Malate dehydrogenase; n=13; cellular or... 107 4e-22
UniRef50_A0LRV1 Cluster: Lactate/malate dehydrogenase; n=3; Acti... 106 7e-22
UniRef50_Q5LXE1 Cluster: Malate dehydrogenase; n=115; cellular o... 105 1e-21
UniRef50_P0C0J4 Cluster: L-lactate dehydrogenase; n=5; Mycoplasm... 105 2e-21
UniRef50_Q3U1V6 Cluster: Ubiquitin-conjugating enzyme E2 variant... 105 2e-21
UniRef50_A6Q7S2 Cluster: Malate dehydrogenase, NAD-dependent; n=... 104 3e-21
UniRef50_O26290 Cluster: Malate dehydrogenase; n=2; Methanobacte... 104 3e-21
UniRef50_Q4UJ29 Cluster: L-lactate dehydrogenase, putative; n=2;... 103 5e-21
UniRef50_A5Z9B1 Cluster: Putative uncharacterized protein; n=1; ... 103 8e-21
UniRef50_Q3J7E7 Cluster: Malate dehydrogenase; n=5; Gammaproteob... 103 8e-21
UniRef50_Q8RED8 Cluster: L-lactate dehydrogenase; n=3; Fusobacte... 103 8e-21
UniRef50_A7DSJ4 Cluster: Lactate/malate dehydrogenase; n=1; Cand... 101 2e-20
UniRef50_UPI000023CE12 Cluster: hypothetical protein FG10444.1; ... 101 3e-20
UniRef50_Q5CYZ2 Cluster: Lactate dehydrogenase, adjacent gene en... 101 3e-20
UniRef50_Q4A0K7 Cluster: Lactate dehydrogenase; n=1; Staphylococ... 100 6e-20
UniRef50_Q7UY63 Cluster: L-lactate/malate dehydrogenase; n=2; Pl... 100 1e-19
UniRef50_Q6LZI3 Cluster: Malate dehydrogenase; n=5; Methanococcu... 100 1e-19
UniRef50_Q27743 Cluster: L-lactate dehydrogenase; n=17; Apicompl... 99 1e-19
UniRef50_Q8I8U4 Cluster: Lactate dehydrogenase; n=3; Eimeriorina... 98 2e-19
UniRef50_Q6A6E3 Cluster: L-lactate dehydrogenase; n=1; Propionib... 97 4e-19
UniRef50_Q6JH30 Cluster: Lactate dehydrogenase; n=3; Plasmodium ... 97 7e-19
UniRef50_Q92AZ3 Cluster: Lin1775 protein; n=13; Listeria|Rep: Li... 96 1e-18
UniRef50_Q6ABQ3 Cluster: L-lactate dehydrogenase; n=1; Propionib... 95 2e-18
UniRef50_P59050 Cluster: L-lactate dehydrogenase 1; n=3; Bifidob... 95 2e-18
UniRef50_UPI00015BB1FC Cluster: malate dehydrogenase (NAD); n=1;... 95 3e-18
UniRef50_Q87JV1 Cluster: Lactate dehydrogenase; n=4; Vibrio|Rep:... 95 3e-18
UniRef50_Q04GC4 Cluster: Enzyme with possible activities of L-2-... 94 5e-18
UniRef50_A7I2F1 Cluster: Malate dehydrogenase; n=1; Campylobacte... 94 5e-18
UniRef50_A7GYI6 Cluster: Lactate/malate dehydrogenase, NAD bindi... 93 1e-17
UniRef50_A3ZZ88 Cluster: L-lactate/malate dehydrogenase; n=1; Bl... 93 1e-17
UniRef50_Q38YI2 Cluster: Putative malate dehydrogenase; n=1; Lac... 91 3e-17
UniRef50_Q0P989 Cluster: L-lactate dehydrogenase; n=10; Campylob... 91 3e-17
UniRef50_Q03ZZ4 Cluster: Enzyme with possible activities of L-2-... 90 6e-17
UniRef50_O52354 Cluster: L-lactate dehydrogenase; n=1; Mycoplasm... 90 6e-17
UniRef50_Q1FMY2 Cluster: L-lactate dehydrogenase; n=1; Clostridi... 88 3e-16
UniRef50_Q6VVP7 Cluster: Malate dehydrogenase; n=6; Plasmodium|R... 87 7e-16
UniRef50_Q5M0L6 Cluster: L-2-hydroxyisocaproate dehydrogenase; n... 86 1e-15
UniRef50_Q5B0T8 Cluster: Putative uncharacterized protein; n=1; ... 86 1e-15
UniRef50_Q7M9A7 Cluster: Malate dehydrogenase; n=4; Epsilonprote... 85 2e-15
UniRef50_A2QJT7 Cluster: Catalytic activity: precursor; n=1; Asp... 85 3e-15
UniRef50_P14295 Cluster: L-2-hydroxyisocaproate dehydrogenase; n... 84 4e-15
UniRef50_P11386 Cluster: Malate dehydrogenase; n=6; Sulfolobacea... 82 2e-14
UniRef50_Q0PQR8 Cluster: Malate dehydrogenase NAD-dependent; n=1... 82 2e-14
UniRef50_Q6YPG1 Cluster: Putative uncharacterized protein OJA121... 81 3e-14
UniRef50_Q9PHY2 Cluster: Probable malate dehydrogenase; n=12; Ca... 80 6e-14
UniRef50_A4E9T4 Cluster: Putative uncharacterized protein; n=1; ... 80 9e-14
UniRef50_Q7VFV4 Cluster: Malate dehydrogenase; n=1; Helicobacter... 79 1e-13
UniRef50_Q82R06 Cluster: Putative lactate dehydrogenase; n=1; St... 77 6e-13
UniRef50_Q2FPC3 Cluster: Lactate/malate dehydrogenase; n=2; Meth... 77 8e-13
UniRef50_Q7MTK2 Cluster: Malate dehydrogenase; n=4; Bacteroidale... 76 1e-12
UniRef50_Q5FIY9 Cluster: L-LDH; n=6; Lactobacillus|Rep: L-LDH - ... 75 2e-12
UniRef50_Q8IE66 Cluster: Oxidoreductase, putative; n=6; Plasmodi... 75 3e-12
UniRef50_A2SNY0 Cluster: Malate/lactate dehydrogenases-like prot... 73 1e-11
UniRef50_Q88ZG9 Cluster: L-2-hydroxyisocaproate dehydrogenase; n... 73 1e-11
UniRef50_A5IYS9 Cluster: L-lactate dehydrogenase; n=2; Mycoplasm... 73 1e-11
UniRef50_A3CTN0 Cluster: Lactate/malate dehydrogenase; n=1; Meth... 71 4e-11
UniRef50_Q034P5 Cluster: Enzyme with possible activities of L-2-... 69 1e-10
UniRef50_A2SR33 Cluster: Lactate/malate dehydrogenase; n=1; Meth... 64 3e-09
UniRef50_Q64YY6 Cluster: Malate dehydrogenase; n=5; Bacteroidale... 58 2e-07
UniRef50_Q1U8H4 Cluster: L-lactate dehydrogenase; n=2; Lactobaci... 57 5e-07
UniRef50_Q86S07 Cluster: NAD-specific malate dehydrogenase 2; n=... 53 8e-06
UniRef50_Q5ENS5 Cluster: Malate dehydrogenase; n=1; Heterocapsa ... 51 3e-05
UniRef50_Q8Y860 Cluster: Lmo1057 protein; n=11; Listeria|Rep: Lm... 51 5e-05
UniRef50_A7TL95 Cluster: Putative uncharacterized protein; n=1; ... 48 4e-04
UniRef50_Q4Q3J3 Cluster: Malate dehydrogenase, putative; n=3; Le... 47 7e-04
UniRef50_Q039N1 Cluster: Malate/lactate dehydrogenase; n=1; Lact... 45 0.002
UniRef50_Q1WU75 Cluster: Lactate/malate dehydrogenase; n=1; Lact... 43 0.009
UniRef50_UPI0000DB76D8 Cluster: PREDICTED: similar to CG7998-PA;... 42 0.021
UniRef50_Q03QL8 Cluster: Malate/lactate dehydrogenase; n=1; Lact... 42 0.021
UniRef50_P40925 Cluster: Malate dehydrogenase, cytoplasmic; n=12... 41 0.048
UniRef50_Q9VU29 Cluster: Malate dehydrogenase; n=5; Protostomia|... 40 0.064
UniRef50_Q5NDY3 Cluster: Putative l-lactate dehydrogenase; n=1; ... 40 0.085
UniRef50_Q6CP51 Cluster: Similar to sp|P22133 Saccharomyces cere... 38 0.34
UniRef50_Q01JC3 Cluster: Malate dehydrogenase; n=8; cellular org... 37 0.60
UniRef50_A5I533 Cluster: Putative malate/lactate dehydrogenase; ... 35 3.2
UniRef50_UPI0000499B99 Cluster: protein kinase; n=3; Entamoeba h... 34 4.2
UniRef50_A2YRW8 Cluster: Putative uncharacterized protein; n=2; ... 34 4.2
UniRef50_Q8EYH1 Cluster: Methyl-accepting chemotaxis protein; n=... 34 5.6
UniRef50_A0W7C0 Cluster: Diguanylate cyclase/phosphodiesterase w... 34 5.6
UniRef50_Q15QV8 Cluster: Putative uncharacterized protein; n=1; ... 33 7.4
UniRef50_A3YGJ3 Cluster: Beta-ketoacyl synthase; n=1; Marinomona... 33 7.4
>UniRef50_P07864 Cluster: L-lactate dehydrogenase C chain; n=371;
Eukaryota|Rep: L-lactate dehydrogenase C chain - Homo
sapiens (Human)
Length = 332
Score = 255 bits (624), Expect = 1e-66
Identities = 112/175 (64%), Positives = 143/175 (81%)
Frame = +2
Query: 332 AKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILV 511
+KI S DYS++A S+I +VTAG RQ+EGE+RL LVQRN ++K IIP ++ YSPD ++
Sbjct: 75 SKITSGKDYSVSANSRIVIVTAGARQQEGETRLALVQRNVAIMKSIIPAIVHYSPDCKIL 134
Query: 512 IASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHG 691
+ SNPVDILTY+ WKISGLP RVIGSG NLDSARFRYL+ ++LG+ TSCHG+IIGEHG
Sbjct: 135 VVSNPVDILTYIVWKISGLPVTRVIGSGCNLDSARFRYLIGEKLGVHPTSCHGWIIGEHG 194
Query: 692 DSSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTS 856
DSSVP+WS VN+AGV L L+ ++GTD D E+WK +H+ V++SAY +IKLKGYTS
Sbjct: 195 DSSVPLWSGVNVAGVALKTLDPKLGTDSDKEHWKNIHKQVIQSAYEIIKLKGYTS 249
Score = 39.1 bits (87), Expect = 0.15
Identities = 19/39 (48%), Positives = 24/39 (61%)
Frame = +1
Query: 205 LAAAFSXLTQHVTHHIALVAMXAXKLKGXXMDLQHGSAF 321
+A A S L + + +ALV + KLKG MDLQHGS F
Sbjct: 33 MACAISILLKDLADELALVDVALDKLKGEMMDLQHGSLF 71
>UniRef50_Q4SRH5 Cluster: L-lactate dehydrogenase; n=4;
Euteleostomi|Rep: L-lactate dehydrogenase - Tetraodon
nigroviridis (Green puffer)
Length = 360
Score = 247 bits (605), Expect = 3e-64
Identities = 113/181 (62%), Positives = 142/181 (78%)
Frame = +2
Query: 332 AKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILV 511
+KI + DYS+TA S++ VVTAGVRQ+EGESRL+LVQRN +V K IIPQ+IKYSP+ L+
Sbjct: 76 SKIVADKDYSVTANSRLVVVTAGVRQQEGESRLNLVQRNVNVFKSIIPQIIKYSPNCTLI 135
Query: 512 IASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHG 691
+ SNPVD+LTYVTWK+SGLPKHRVIGSGTNLDSARFRYL+++RLGI +S +G+++GEHG
Sbjct: 136 VVSNPVDVLTYVTWKLSGLPKHRVIGSGTNLDSARFRYLMAERLGIHASSFNGWVLGEHG 195
Query: 692 DSSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXGXSD 871
D+SVPVWS N+AGV L LN IGTDDD E W+ H+ VV S + + T+ D
Sbjct: 196 DTSVPVWSGANVAGVNLQKLNPDIGTDDDKEEWRATHKAVVDSLRTALPVP-LTTLSIQD 254
Query: 872 C 874
C
Sbjct: 255 C 255
Score = 39.5 bits (88), Expect = 0.11
Identities = 18/41 (43%), Positives = 26/41 (63%)
Frame = +1
Query: 205 LAAAFSXLTQHVTHHIALVAMXAXKLKGXXMDLQHGSAFMR 327
+A A S L + + +ALV + +LKG MDLQHGS F++
Sbjct: 34 MACAISILLRDLADELALVDVMEDRLKGELMDLQHGSLFLK 74
>UniRef50_UPI0000519EC7 Cluster: PREDICTED: similar to
Ecdysone-inducible gene L3 CG10160-PA; n=2;
Apocrita|Rep: PREDICTED: similar to Ecdysone-inducible
gene L3 CG10160-PA - Apis mellifera
Length = 409
Score = 221 bits (541), Expect = 1e-56
Identities = 101/174 (58%), Positives = 134/174 (77%)
Frame = +2
Query: 335 KIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVI 514
+I TD+ IT+ SK+ V+ AG RQ +GESRLDLVQRN+++LK IIP L+ YSP+ ++++
Sbjct: 152 RIDFDTDFCITSNSKVIVLAAGARQMKGESRLDLVQRNSEILKSIIPTLVGYSPNAVILV 211
Query: 515 ASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGD 694
SNPVDIL+++TWKISGLP RVIG+GT++DSARFR+L++DRLGIA +S H IIGEHGD
Sbjct: 212 VSNPVDILSWLTWKISGLPASRVIGTGTHVDSARFRFLIADRLGIAPSSVHATIIGEHGD 271
Query: 695 SSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTS 856
S VP+WS VN+AGV+ D+ IG + D E W EL + VV+ V LKGYT+
Sbjct: 272 SQVPLWSGVNVAGVQFRDILPNIGLETDEERWYELSKEVVRLGPTVRCLKGYTN 325
>UniRef50_Q7NG49 Cluster: L-lactate dehydrogenase; n=4;
Cyanobacteria|Rep: L-lactate dehydrogenase - Gloeobacter
violaceus
Length = 330
Score = 194 bits (474), Expect = 2e-48
Identities = 88/162 (54%), Positives = 120/162 (74%)
Frame = +2
Query: 371 GSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYVT 550
G + V+TAG RQREGE+RL LVQRN ++ + +I +++++ P+ IL++ SNPVD++TYV
Sbjct: 87 GVDVVVITAGARQREGETRLSLVQRNVEIFRGLIGEIMEHCPNAILLVVSNPVDVMTYVA 146
Query: 551 WKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSAVNIA 730
K++GLP RVIGSGT LD+ARFRYLL++RL + S H YIIGEHGDS VPVWS N+A
Sbjct: 147 MKLAGLPPSRVIGSGTVLDTARFRYLLAERLRVDPRSLHAYIIGEHGDSEVPVWSRANVA 206
Query: 731 GVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTS 856
G LS++ +GT DDP E+ E+V +AY +I+ KG TS
Sbjct: 207 GAFLSEIEPAVGTPDDPAKMFEVFEHVKNAAYEIIERKGATS 248
>UniRef50_UPI0000DB7268 Cluster: PREDICTED: similar to L-lactate
dehydrogenase A chain (LDH-A) (LDH muscle subunit)
(LDH-M); n=2; Apis mellifera|Rep: PREDICTED: similar to
L-lactate dehydrogenase A chain (LDH-A) (LDH muscle
subunit) (LDH-M) - Apis mellifera
Length = 348
Score = 183 bits (445), Expect = 6e-45
Identities = 80/183 (43%), Positives = 119/183 (65%)
Frame = +2
Query: 326 GNAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTI 505
GN KI + DYS+ + +CV+T G R + L+++N ++ K +IP++ KY+P++I
Sbjct: 85 GNPKIIGTKDYSLARDATVCVITIGDRSTNEQDPSTLLEQNLNIFKDVIPKVCKYAPNSI 144
Query: 506 LVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGE 685
L+I + PVDIL+Y K+SG P HRV+G GT LDS RF+Y ++ +LGI+ +S +I E
Sbjct: 145 LLIVTAPVDILSYAAMKLSGFPPHRVVGLGTFLDSCRFQYFIAQKLGISASSVQASVICE 204
Query: 686 HGDSSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXGX 865
+G +SVP+WSAV + G++L D+N IGT DPE+W ELH V+ +I KGY G
Sbjct: 205 NGPTSVPIWSAVTVMGIKLKDINKDIGTKADPESWGELHAKVIDCDNDLISRKGYRCWGM 264
Query: 866 SDC 874
C
Sbjct: 265 GIC 267
>UniRef50_Q8XP62 Cluster: L-lactate dehydrogenase; n=11;
Clostridium|Rep: L-lactate dehydrogenase - Clostridium
perfringens
Length = 317
Score = 182 bits (444), Expect = 8e-45
Identities = 82/170 (48%), Positives = 117/170 (68%)
Frame = +2
Query: 347 STDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 526
S DY+ T S I ++TAGV + GE+RLD++ +N + + I+P+++KYSP++IL++ SNP
Sbjct: 65 SGDYADTKDSDIVIITAGVGPKPGETRLDIINKNLKIFQSIVPEVVKYSPNSILLVVSNP 124
Query: 527 VDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVP 706
VDILTY+T+K+SG PK RVIGSGT LD++R +Y+LS+ I + H YIIGEHGDS +
Sbjct: 125 VDILTYITYKLSGFPKERVIGSGTVLDTSRLKYMLSEHFDIDARNVHTYIIGEHGDSEIT 184
Query: 707 VWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTS 856
WS NIAG + + + + D KEL E V +AY +I KGYT+
Sbjct: 185 AWSLTNIAGANVEEYCKTVCANCDGSFKKELPEKVKNAAYEIINSKGYTN 234
>UniRef50_Q892U0 Cluster: L-lactate dehydrogenase; n=12;
Bacteria|Rep: L-lactate dehydrogenase - Clostridium
tetani
Length = 316
Score = 178 bits (434), Expect = 1e-43
Identities = 82/168 (48%), Positives = 113/168 (67%)
Frame = +2
Query: 353 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 532
DY T S I ++TAG + GE+RLDL+ +N ++ K I+P+++KYSP +IL++ SNPVD
Sbjct: 66 DYEDTKDSDIVIITAGAGPKPGETRLDLINKNYEIFKGIVPEVVKYSPKSILLVVSNPVD 125
Query: 533 ILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVW 712
ILTYVT+K+SG P+ RVIGSGT LD++RFRYLL + I + H YI+GEHGDS + W
Sbjct: 126 ILTYVTYKLSGFPQERVIGSGTVLDTSRFRYLLGEHFKIDVRNVHTYILGEHGDSEIAAW 185
Query: 713 SAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTS 856
S NIAG+ + D I + + E V +AY V++ KGYTS
Sbjct: 186 SLTNIAGISVEDYCKDICKGCEGNFKNRIPEEVKNAAYEVLERKGYTS 233
>UniRef50_P22988 Cluster: L-lactate dehydrogenase A; n=19;
Magnoliophyta|Rep: L-lactate dehydrogenase A - Hordeum
vulgare (Barley)
Length = 356
Score = 175 bits (427), Expect = 9e-43
Identities = 80/171 (46%), Positives = 115/171 (67%)
Frame = +2
Query: 344 SSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASN 523
S TD ++T S + +VTAG RQ GE+RL+L+QRN + ++I+P + ++SPD +L++ SN
Sbjct: 101 SGTDAAVTKNSDLVIVTAGARQIPGETRLNLLQRNVALYRKIVPPVAEHSPDALLLVVSN 160
Query: 524 PVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSV 703
PVD+LTYV WK+SG P RVIGSGTNLDS+RFR+L+++ L + Y++GEHGDSSV
Sbjct: 161 PVDVLTYVAWKLSGFPASRVIGSGTNLDSSRFRFLIAEHLDVNAQDVQAYMVGEHGDSSV 220
Query: 704 PVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTS 856
+WS++++ G+ D + + VV AY VI LKGYTS
Sbjct: 221 AIWSSISVGGMPAFKSLRDSHRSFDEAALEGIRRAVVGGAYEVIGLKGYTS 271
Score = 37.9 bits (84), Expect = 0.34
Identities = 18/40 (45%), Positives = 26/40 (65%)
Frame = +1
Query: 205 LAAAFSXLTQHVTHHIALVAMXAXKLKGXXMDLQHGSAFM 324
+A A + LTQ++ IALV KL+G +DLQH +AF+
Sbjct: 56 MAIAQTILTQNLADEIALVDALPDKLRGEALDLQHAAAFL 95
>UniRef50_Q1IRL5 Cluster: L-lactate dehydrogenase; n=6;
Bacteria|Rep: L-lactate dehydrogenase - Acidobacteria
bacterium (strain Ellin345)
Length = 321
Score = 174 bits (423), Expect = 3e-42
Identities = 78/167 (46%), Positives = 114/167 (68%)
Frame = +2
Query: 353 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 532
+Y+ G+ + V+TAG QR GE+RL L+ RN + +QI+P+++K++PD +L+IA+NPVD
Sbjct: 71 EYADCRGAAVTVITAGAAQRPGETRLQLLDRNLAIFQQIVPEVVKHNPDGLLLIATNPVD 130
Query: 533 ILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVW 712
I++Y ++KISGLP HRV+GSGT LD+ARFRYLL + S HG I+GEHGD+ VP+W
Sbjct: 131 IISYASYKISGLPAHRVLGSGTILDTARFRYLLGQHFSVDARSVHGLILGEHGDTEVPIW 190
Query: 713 SAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYT 853
S NIAG+RL + D + + + +AY +I+ KG T
Sbjct: 191 SLANIAGIRLREYCRLHSLPYDEHVFDTIFTDTRDAAYKIIERKGAT 237
>UniRef50_Q6NPB9 Cluster: AT22132p; n=2; Drosophila
melanogaster|Rep: AT22132p - Drosophila melanogaster
(Fruit fly)
Length = 361
Score = 168 bits (408), Expect = 2e-40
Identities = 73/177 (41%), Positives = 118/177 (66%), Gaps = 1/177 (0%)
Frame = +2
Query: 329 NAKIQSSTDYSITAGSKICVVTAGVRQR-EGESRLDLVQRNTDVLKQIIPQLIKYSPDTI 505
+A++ D + + S + ++TAG R + SRL +Q+ ++LK+ +P+L++ SP+
Sbjct: 102 DARVVPCGDSTNSKDSDVVIITAGARPSGKDRSRLAAMQKTVEILKKAVPKLVELSPNAT 161
Query: 506 LVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGE 685
+I SNP D++TY +I+ LPKHR +G +LD+ RFR L+++RL + + HGY+IGE
Sbjct: 162 FIIISNPADVMTYAVQRITNLPKHRCFTTGCHLDTVRFRNLIANRLRLPPSQVHGYVIGE 221
Query: 686 HGDSSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTS 856
HG S+VPVWS+V+IAG+RL+D+ + DDPENW ++++ V V K KGYT+
Sbjct: 222 HGASAVPVWSSVSIAGIRLNDVVKNLACGDDPENWAKINKQVTTGGLAVAKTKGYTN 278
>UniRef50_Q81K80 Cluster: L-lactate dehydrogenase 2; n=12;
Firmicutes|Rep: L-lactate dehydrogenase 2 - Bacillus
anthracis
Length = 314
Score = 167 bits (407), Expect = 2e-40
Identities = 85/174 (48%), Positives = 116/174 (66%), Gaps = 2/174 (1%)
Frame = +2
Query: 347 STDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 526
S Y+ + + V+TAG+ Q+ GE+RLDLV++NT + KQI+ ++ D I +IA+NP
Sbjct: 65 SGSYADCKDADLVVITAGLPQKPGETRLDLVEKNTKIFKQIVRGIMDSGFDGIFLIATNP 124
Query: 527 VDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVP 706
VDILTYVTWK SGLPK RVIGSGT LDSARFRY+L D L + + H YI+GEHGD+ +P
Sbjct: 125 VDILTYVTWKESGLPKERVIGSGTTLDSARFRYMLGDYLDVDPRNVHAYIVGEHGDTELP 184
Query: 707 VWSAVNIAGVRLSDL--NNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
VWS I +L + NN+ +D + ++ ENV +AY +I+ KG T G
Sbjct: 185 VWSHATIGVQKLETILANNEQYKQEDLD---KIFENVRDAAYHIIERKGATYYG 235
>UniRef50_A4QXM2 Cluster: Putative uncharacterized protein; n=1;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 323
Score = 163 bits (397), Expect = 4e-39
Identities = 75/171 (43%), Positives = 110/171 (64%), Gaps = 1/171 (0%)
Frame = +2
Query: 353 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKY-SPDTILVIASNPV 529
DY G+ + ++TAG Q+ G+SR++L Q N + K+I+P+++++ SPD +L++++NPV
Sbjct: 73 DYEDCKGASVIILTAGANQKPGQSRMELAQSNWGIFKEIVPKVVQHASPDALLLVSANPV 132
Query: 530 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPV 709
D++TY K SG P H VIGSGT+LDSARF L L I S H +IGEHG+S +PV
Sbjct: 133 DVMTYAAVKFSGFPAHSVIGSGTSLDSARFAGELGKHLNIDPRSLHAVVIGEHGESELPV 192
Query: 710 WSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
WS ++G+R+ D Q GT D E K+ NV +A +I+ KG T G
Sbjct: 193 WSLATVSGMRVEDYCRQTGTPWDEETKKQCFANVKDAAAAIIEKKGVTGYG 243
>UniRef50_P19869 Cluster: L-lactate dehydrogenase 2; n=17;
Bacteria|Rep: L-lactate dehydrogenase 2 -
Bifidobacterium longum
Length = 320
Score = 163 bits (395), Expect = 7e-39
Identities = 76/174 (43%), Positives = 114/174 (65%), Gaps = 1/174 (0%)
Frame = +2
Query: 338 IQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIA 517
I S D I + + V+TAG RQ+ G+SRL+LV ++LK I+P L+K +P+ I ++
Sbjct: 65 IDGSDDPEICRDADMVVITAGPRQKPGQSRLELVGATVNILKAIMPNLVKVAPNAIYMLI 124
Query: 518 SNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDS 697
+NPVDI T+V K++GLP++++ GSGTNLDSAR R+L++ + G+ + H YI GEHGDS
Sbjct: 125 TNPVDIATHVAQKLTGLPENQIFGSGTNLDSARLRFLIAQQTGVNVKNVHAYIAGEHGDS 184
Query: 698 SVPVWSAVNIAGVRLSDLNNQIGTDD-DPENWKELHENVVKSAYXVIKLKGYTS 856
VP+W + I GV + D G D D + +E+H+ V +AY +I KG T+
Sbjct: 185 EVPLWESATIGGVPMCDWTPLPGHDPLDADKREEIHQEVKNAAYKIINGKGATN 238
>UniRef50_P0A3M9 Cluster: L-lactate dehydrogenase; n=140;
Bacteria|Rep: L-lactate dehydrogenase - Streptococcus
pneumoniae
Length = 328
Score = 162 bits (393), Expect = 1e-38
Identities = 82/172 (47%), Positives = 108/172 (62%)
Frame = +2
Query: 347 STDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 526
+ YS A + + V+TAG Q+ GE+RLDLV +N + K I+ Q+++ I ++A+NP
Sbjct: 68 AAQYSDCADADLVVITAGAPQKPGETRLDLVGKNLAINKSIVTQVVESGFKGIFLVAANP 127
Query: 527 VDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVP 706
VD+LTY TWK SG PK RVIGSGT+LDSARFR L+++L + S H YI+GEHGDS
Sbjct: 128 VDVLTYSTWKFSGFPKERVIGSGTSLDSARFRQALAEKLDVDARSVHAYIMGEHGDSEFA 187
Query: 707 VWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
VWS NIAGV L + + E EL E V +AY +I KG T G
Sbjct: 188 VWSHANIAGVNLEEFLKDTQNVQEAE-LIELFEGVRDAAYTIINKKGATYYG 238
>UniRef50_A5KJY5 Cluster: Putative uncharacterized protein; n=2;
Ruminococcus|Rep: Putative uncharacterized protein -
Ruminococcus torques ATCC 27756
Length = 316
Score = 161 bits (390), Expect = 3e-38
Identities = 73/170 (42%), Positives = 114/170 (67%)
Frame = +2
Query: 353 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 532
+Y A + + ++TAG Q+ GE+RLDLVQ+N +++ II ++ + + + IL+I SNPVD
Sbjct: 65 EYEDIADASVVIITAGANQKPGETRLDLVQKNAAIMRSIIKEIKRVNCEGILLIVSNPVD 124
Query: 533 ILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVW 712
ILT V + SG PK RVIGSGT LD+AR +Y++S++L + + + H +I+GEHGDS + W
Sbjct: 125 ILTEVALRESGFPKERVIGSGTVLDTARLKYIISEKLDVDSRNVHAFIVGEHGDSELAAW 184
Query: 713 SAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
S NI G++L D G + ++ +E+++ V SAY +I+ KG T G
Sbjct: 185 SCANIYGIKLQDFAKMRGYEHFAQDMEEVYKGVRDSAYEIIERKGATYYG 234
>UniRef50_P20619 Cluster: L-lactate dehydrogenase X; n=14;
Bacillales|Rep: L-lactate dehydrogenase X - Bacillus
psychrosaccharolyticus
Length = 319
Score = 160 bits (389), Expect = 4e-38
Identities = 80/170 (47%), Positives = 109/170 (64%)
Frame = +2
Query: 353 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 532
+Y + I + AG Q+ GE+RLDLV++N + K ++ Q++ D I +IA+NPVD
Sbjct: 68 NYDDCKEADIVCICAGANQKPGETRLDLVEKNLKIFKSLVDQVMASGFDGIFLIATNPVD 127
Query: 533 ILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVW 712
ILTY TWK SGLPK RVIGSGT LDS RFR+LL + IA + H +IIGEHGD+ +PVW
Sbjct: 128 ILTYATWKFSGLPKERVIGSGTILDSGRFRFLLGEYFDIAPANVHAHIIGEHGDTELPVW 187
Query: 713 SAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
S +I GV + +L + + E+ +L NV +AY +IK KG T G
Sbjct: 188 SHADIGGVPVEELITR-NPEYKMEDLDQLFVNVRDAAYHIIKKKGATYYG 236
>UniRef50_A3DCA4 Cluster: L-lactate dehydrogenase precursor; n=2;
Clostridium|Rep: L-lactate dehydrogenase precursor -
Clostridium thermocellum (strain ATCC 27405 / DSM 1237)
Length = 318
Score = 159 bits (386), Expect = 9e-38
Identities = 76/170 (44%), Positives = 112/170 (65%)
Frame = +2
Query: 353 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 532
DYS + VVTAG ++ GE+RLDL ++N + K++ ++KY ++++ SNPVD
Sbjct: 68 DYSDVKDCDVIVVTAGANRKPGETRLDLAKKNVMIAKEVTQNIMKYYNHGVILVVSNPVD 127
Query: 533 ILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVW 712
I+TY+ K SGLP +VIGSGT LDS RFRYLLS++LG+ + HGYIIGEHGDS +P+W
Sbjct: 128 IITYMIQKWSGLPVGKVIGSGTVLDSIRFRYLLSEKLGVDVKNVHGYIIGEHGDSQLPLW 187
Query: 713 SAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
S +IAG +++ + + E+ K++ E+V + +IK KG T G
Sbjct: 188 SCTHIAGKNINEYIDDPKCNFTEEDKKKIAEDVKTAGATIIKNKGATYYG 237
>UniRef50_O51114 Cluster: L-lactate dehydrogenase; n=4; Borrelia
burgdorferi group|Rep: L-lactate dehydrogenase -
Borrelia burgdorferi (Lyme disease spirochete)
Length = 316
Score = 156 bits (378), Expect = 8e-37
Identities = 81/166 (48%), Positives = 106/166 (63%)
Frame = +2
Query: 356 YSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDI 535
Y A + I V+TAG+ Q+ GE+RLDLV +N+ + K II ++ D I V+ASNPVDI
Sbjct: 68 YKDCANADIVVITAGLNQKPGETRLDLVDKNSKIFKDIITNVVSSGFDGIFVVASNPVDI 127
Query: 536 LTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 715
+TYVT K S P H+VIG+GT LD++R RY LSD + T + H YI+GEHGDSS W
Sbjct: 128 MTYVTMKYSKFPIHKVIGTGTILDTSRLRYFLSDHFNVNTQNIHSYIMGEHGDSSFATWD 187
Query: 716 AVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYT 853
IA LS+ + G + E E+H+ VV +AY VIKLKG T
Sbjct: 188 ETKIAMKPLSEYLAE-GKITELE-LDEIHKKVVNAAYEVIKLKGAT 231
>UniRef50_Q9P7P7 Cluster: Probable L-lactate dehydrogenase; n=2;
Ascomycota|Rep: Probable L-lactate dehydrogenase -
Schizosaccharomyces pombe (Fission yeast)
Length = 330
Score = 155 bits (375), Expect = 2e-36
Identities = 73/170 (42%), Positives = 108/170 (63%)
Frame = +2
Query: 353 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 532
DY + V+TAG Q+ GE+R+DL++ N + K+I+ ++ KY+ D IL++A+NPVD
Sbjct: 81 DYKDCKDATAVVITAGKNQKPGETRMDLLKANISIFKEILREVTKYTKDAILLVATNPVD 140
Query: 533 ILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVW 712
+LTY T K++G P RVIGSGT +D+ARF+YL+ G+ S + IIGEHGDS + VW
Sbjct: 141 VLTYATLKLTGFPAERVIGSGTIIDTARFQYLIGKLYGLDPQSVNADIIGEHGDSELAVW 200
Query: 713 SAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
S +IAG+ L+D + T D + E + +AY +I+ KG T G
Sbjct: 201 SHASIAGLSLADFCEESETKYDEQALNECFKETKNAAYDIIQRKGSTEYG 250
>UniRef50_A6NLX8 Cluster: L-lactate dehydrogenase; n=4;
Eutheria|Rep: L-lactate dehydrogenase - Homo sapiens
(Human)
Length = 253
Score = 154 bits (373), Expect = 3e-36
Identities = 67/130 (51%), Positives = 94/130 (72%)
Frame = +2
Query: 332 AKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILV 511
+ I S DY +TA + ++TAG R+ +GE R +LV++N + K +I +++ SP L+
Sbjct: 124 SNIVCSKDYLVTANPHLVIITAGARREKGEMRFNLVRQNVAIFKLMISSIVQQSPLCKLI 183
Query: 512 IASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHG 691
I SNPVDILTYV WK+S PK+RVIGSG NLD+ RF++ + +LGI + SC G+I+GEHG
Sbjct: 184 IVSNPVDILTYVAWKLSAFPKNRVIGSGCNLDTVRFQFFIGQKLGIHSESCRGWILGEHG 243
Query: 692 DSSVPVWSAV 721
DSSVPVWS +
Sbjct: 244 DSSVPVWSGM 253
Score = 37.1 bits (82), Expect = 0.60
Identities = 18/41 (43%), Positives = 25/41 (60%)
Frame = +1
Query: 205 LAAAFSXLTQHVTHHIALVAMXAXKLKGXXMDLQHGSAFMR 327
+A A S L + ++ +A V + KLKG MDLQH S FM+
Sbjct: 82 MACATSILLKGLSDELAFVDLDEGKLKGETMDLQHDSPFMK 122
>UniRef50_Q838C9 Cluster: L-lactate dehydrogenase 2; n=9;
Bacilli|Rep: L-lactate dehydrogenase 2 - Enterococcus
faecalis (Streptococcus faecalis)
Length = 317
Score = 152 bits (368), Expect = 1e-35
Identities = 82/173 (47%), Positives = 106/173 (61%), Gaps = 3/173 (1%)
Frame = +2
Query: 353 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 532
DY + I V+TAG Q+ G+SRLDLV N +++K I+ ++K D ILVIASNPVD
Sbjct: 67 DYQDCQDADIVVITAGANQKPGQSRLDLVSINAEIMKTIVNNIMKSGFDGILVIASNPVD 126
Query: 533 ILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVW 712
+LTYV W+ SGLP RVIG+GT LD+ RFR LS RL I + HGYIIGEHGDS V VW
Sbjct: 127 VLTYVAWQASGLPVSRVIGTGTTLDTTRFRKELSQRLAIDPRNVHGYIIGEHGDSEVAVW 186
Query: 713 SAVNIAG---VRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
S I + + D ++ +DD P + + V +AY +I K T G
Sbjct: 187 SHTMIGTKPILEIVDTTERLTSDDLP----IISDKVKNTAYEIIDRKQATYYG 235
>UniRef50_Q4JY42 Cluster: L-lactate dehydrogenase; n=1;
Corynebacterium jeikeium K411|Rep: L-lactate
dehydrogenase - Corynebacterium jeikeium (strain K411)
Length = 326
Score = 151 bits (366), Expect = 2e-35
Identities = 77/178 (43%), Positives = 108/178 (60%)
Frame = +2
Query: 329 NAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTIL 508
N ++ T + +C+ AG Q+ GE+RLDLV +NT + K I+ ++ + + I
Sbjct: 70 NTRVTVGTYEDCRDAAMVCIC-AGAAQKPGETRLDLVAKNTAIFKTIVGDVMSHGFNGIF 128
Query: 509 VIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEH 688
++ASNPVDIL+Y TWK SG+ RVIGSGT LD+ARFRY L +A TS H Y+IGEH
Sbjct: 129 LVASNPVDILSYATWKFSGMDSSRVIGSGTILDTARFRYALGRYFDLAPTSVHAYVIGEH 188
Query: 689 GDSSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
GD+ +PV SA ++AG + IG D E+ E+ +AY +I+ KG TS G
Sbjct: 189 GDTELPVLSAGSVAGTSIHHRLEMIGESAD-EDVDEIFVKTRDAAYEIIQAKGSTSFG 245
>UniRef50_A3JXA9 Cluster: L-lactate dehydrogenase; n=1; Sagittula
stellata E-37|Rep: L-lactate dehydrogenase - Sagittula
stellata E-37
Length = 300
Score = 150 bits (364), Expect = 4e-35
Identities = 73/169 (43%), Positives = 106/169 (62%)
Frame = +2
Query: 356 YSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDI 535
Y +G+ + ++ GV Q+ GESRL+L+ RN +V + ++ + + +PD IL+IASNPVDI
Sbjct: 53 YDDLSGADVVILACGVSQKPGESRLELLSRNAEVFRAVVGDVTRAAPDAILLIASNPVDI 112
Query: 536 LTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 715
+T+VT +SGLP RVIGSGT LD+ARFR+LL L IA S H Y++GEHGD+ V W+
Sbjct: 113 MTHVTQALSGLPAGRVIGSGTILDTARFRWLLGRHLNIAPRSVHAYVLGEHGDTEVLAWT 172
Query: 716 AVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
A V + QI + + + + V +AY +I+ KG T G
Sbjct: 173 AARAGSVSIESFAAQIRAPLTADVRERIDKGVRNAAYTIIEGKGATWYG 221
>UniRef50_P16115 Cluster: L-lactate dehydrogenase; n=4;
Thermotogaceae|Rep: L-lactate dehydrogenase - Thermotoga
maritima
Length = 319
Score = 150 bits (363), Expect = 5e-35
Identities = 74/167 (44%), Positives = 106/167 (63%)
Frame = +2
Query: 353 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 532
DY+ GS + +V AGV Q+ GE+RL L+ RN V+K+I + KY+PD+I+++ +NPVD
Sbjct: 61 DYADLKGSDVVIVAAGVPQKPGETRLQLLGRNARVMKEIARNVSKYAPDSIVIVVTNPVD 120
Query: 533 ILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVW 712
+LTY K SG+ +V GSGT LD+AR R L++ G + S H Y+IGEHGDS VPVW
Sbjct: 121 VLTYFFLKESGMDPRKVFGSGTVLDTARLRTLIAQHCGFSPRSVHVYVIGEHGDSEVPVW 180
Query: 713 SAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYT 853
S I G+ L ++ QI D + + E ++AY +I+ KG T
Sbjct: 181 SGAMIGGIPLQNM-CQICQKCDSKILENFAEKTKRAAYEIIERKGAT 226
>UniRef50_UPI00015B6427 Cluster: PREDICTED: similar to lactate
dehydrogenase; n=1; Nasonia vitripennis|Rep: PREDICTED:
similar to lactate dehydrogenase - Nasonia vitripennis
Length = 352
Score = 149 bits (361), Expect = 9e-35
Identities = 69/175 (39%), Positives = 114/175 (65%), Gaps = 1/175 (0%)
Frame = +2
Query: 326 GNAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTI 505
G+ KI++STDYS + +CV+ AG +QR+ ++Q+N +LK+++P L KY+P+++
Sbjct: 90 GSPKIRASTDYSEARDATLCVIAAGRQQRDEADAEAVLQQNALLLKELVPSLTKYAPNSV 149
Query: 506 LVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGE 685
L++ S PVD+L+++ K+SG P RV+G GT LD+ R ++ L+ LG+ + H +I E
Sbjct: 150 LLVVSEPVDVLSHLAMKLSGFPSQRVLGLGTLLDNCRLQHELAKELGVNQAAVHSMVIAE 209
Query: 686 HGDSSVPVWSAVNIAGVRLSDLNNQIGTDDDPENW-KELHENVVKSAYXVIKLKG 847
G +SVP+WSA ++ G++L D++ IG DPE + LH VV +I+ KG
Sbjct: 210 SGPTSVPIWSAASVMGMKLKDIDKDIG---DPEGFAAALHAKVVNCNRELIRRKG 261
>UniRef50_Q2S4R2 Cluster: L-lactate dehydrogenase; n=1; Salinibacter
ruber DSM 13855|Rep: L-lactate dehydrogenase -
Salinibacter ruber (strain DSM 13855)
Length = 316
Score = 149 bits (360), Expect = 1e-34
Identities = 70/170 (41%), Positives = 111/170 (65%), Gaps = 1/170 (0%)
Frame = +2
Query: 347 STDYSITAGSKICVVTAGVRQRE-GESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASN 523
+ +Y+ + ++I V++AG Q+ E+RL L+QRN ++ ++II QL K++P+ ILV+A+N
Sbjct: 63 AVEYAALSNAQIIVLSAGASQQSPDETRLGLLQRNAEIFREIIIQLDKHAPNAILVVATN 122
Query: 524 PVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSV 703
PVD+LTY+ ++S P R++G+GT LD+ARFR LL G+ S H YI+GEHGDS V
Sbjct: 123 PVDVLTYICQELSSRPNRRILGTGTLLDTARFRALLGRHYGVDPRSVHAYILGEHGDSEV 182
Query: 704 PVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYT 853
P+WS I G ++ +G + + E + + E +AY +I KG+T
Sbjct: 183 PIWSNATIGGQKIRG-ETVLGKEWEEEAMQSIFEQARDAAYEIIDRKGHT 231
>UniRef50_A1U9V0 Cluster: Lactate/malate dehydrogenase; n=6;
Actinomycetales|Rep: Lactate/malate dehydrogenase -
Mycobacterium sp. (strain KMS)
Length = 329
Score = 145 bits (352), Expect = 1e-33
Identities = 69/174 (39%), Positives = 105/174 (60%)
Frame = +2
Query: 335 KIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVI 514
++ S D ++TAGS I VVTAG +Q G+SRLDL N + + + PQL+++SPD +++
Sbjct: 74 RVGGSDDIAVTAGSAIVVVTAGAKQHPGQSRLDLAAANVAMAQTLTPQLLEHSPDAVVIF 133
Query: 515 ASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGD 694
+NPVD++TY + ++ G+GT LDS+RFRYL++ R IA + H +IGEHGD
Sbjct: 134 VTNPVDVVTYAASSVVDAQPGQIFGTGTVLDSSRFRYLVAQRAAIAVGNVHALVIGEHGD 193
Query: 695 SSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTS 856
S +P+WS ++I GV D + +VV +AY +I KG T+
Sbjct: 194 SEIPLWSTLSIGGVGADAYRVDGRLVFDEPTRTAVATDVVNAAYEIIAGKGATN 247
>UniRef50_P62051 Cluster: L-lactate dehydrogenase; n=2;
Desulfovibrio vulgaris subsp. vulgaris|Rep: L-lactate
dehydrogenase - Desulfovibrio vulgaris (strain
Hildenborough / ATCC 29579 / NCIMB8303)
Length = 309
Score = 141 bits (342), Expect = 2e-32
Identities = 71/179 (39%), Positives = 114/179 (63%)
Frame = +2
Query: 326 GNAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTI 505
G +I+S Y G++I VVTAG +Q G+SRLDLV+ N + + I+ +++Y+ D +
Sbjct: 54 GPVQIRSG-GYEQCEGARIVVVTAGAKQMPGQSRLDLVRVNAGITRDILTAVMQYADDPL 112
Query: 506 LVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGE 685
++A+NPVD+LT+V ++G+ RVIGSGT LDSARFR +++ LG+ H +I+GE
Sbjct: 113 YIMATNPVDVLTHVARTVTGVAPGRVIGSGTVLDSARFRGHVAEILGVDVRGVHAHIVGE 172
Query: 686 HGDSSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
HGDS V +WS N++G+ ++++ + G D ++ +V +AY +I KG T G
Sbjct: 173 HGDSEVALWSRANVSGIPVAEMCARRGIAYDAAFREKALGHVRHAAYEIIGRKGATGYG 231
>UniRef50_P50933 Cluster: L-lactate dehydrogenase; n=7;
Bacteria|Rep: L-lactate dehydrogenase - Deinococcus
radiodurans
Length = 304
Score = 140 bits (338), Expect = 6e-32
Identities = 65/169 (38%), Positives = 109/169 (64%)
Frame = +2
Query: 356 YSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDI 535
+S A +++ ++TAG Q+ GESRLDL+++N D+ ++++PQ+ + +PD +L++ SNPVD+
Sbjct: 62 HSELADAQVVILTAGANQKPGESRLDLLEKNADIFRELVPQITRAAPDAVLLVTSNPVDL 121
Query: 536 LTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 715
LT + +++ P VIGSGT LDSARFR+L++ G+ T HGY++GEHGDS V WS
Sbjct: 122 LTDLATQLA--PGQPVIGSGTVLDSARFRHLMAQHAGVDGTHAHGYVLGEHGDSEVLAWS 179
Query: 716 AVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
+ +AG+ ++D + + ++ E +A +I+ K T G
Sbjct: 180 SAMVAGMPVADFMQAQNLPWNEQVRAKIDEGTRNAAASIIEGKRATYYG 228
>UniRef50_P62056 Cluster: L-lactate dehydrogenase; n=2;
Bacteria|Rep: L-lactate dehydrogenase - Treponema
denticola
Length = 315
Score = 138 bits (334), Expect = 2e-31
Identities = 75/169 (44%), Positives = 101/169 (59%), Gaps = 1/169 (0%)
Frame = +2
Query: 350 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 529
TDY A S I VVTAG +Q+ GE+R+DL++RN ++ I + + +++I SNPV
Sbjct: 68 TDY---ADSDIVVVTAGAKQQSGETRIDLLKRNASIITGIAKDIAESGCSGVMLIVSNPV 124
Query: 530 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPV 709
DILT K SG + RVIGSGT LD+ARFRY LS G+ + HGYI+GEHGDS
Sbjct: 125 DILTRAALKASGWERGRVIGSGTVLDTARFRYTLSKECGVDARNIHGYILGEHGDSEFAA 184
Query: 710 WSAVNIAGVRLSDLNNQIGTDDDPENWK-ELHENVVKSAYXVIKLKGYT 853
WS ++AG R+ + + P K ++ E V SAY +I KG T
Sbjct: 185 WSMTSVAGRRIDEYCSGGVCSSGPHFDKAKILEEVRNSAYHIIDYKGST 233
>UniRef50_Q6A9C3 Cluster: L-lactate dehydrogenase; n=2;
Propionibacterium acnes|Rep: L-lactate dehydrogenase -
Propionibacterium acnes
Length = 319
Score = 137 bits (332), Expect = 3e-31
Identities = 67/178 (37%), Positives = 106/178 (59%), Gaps = 3/178 (1%)
Frame = +2
Query: 332 AKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILV 511
A + D TA S + +TAG RQ+ G++RLDL N ++L+ ++PQL++ SP+ + V
Sbjct: 64 ASVMGGADVHDTADSDVVFITAGARQKPGQTRLDLAGVNANILRSLMPQLVEQSPNALFV 123
Query: 512 IASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHG 691
+ +NP D+LT V + +GLP +RV +GT LD++R R+L+ + H I+GEHG
Sbjct: 124 LVTNPCDVLTVVAQEATGLPANRVFSTGTMLDTSRLRWLIRQWANVEQRHVHATIVGEHG 183
Query: 692 DSSVPVWSAVNIAGVRLSDL---NNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTS 856
DS P+WS NI+GV + D N++ T+D +L +AY +I+ KG T+
Sbjct: 184 DSEFPLWSTANISGVPIRDWAVDGNRVFTED---VLADLAHEAAYAAYKIIEGKGATN 238
>UniRef50_Q8ELF0 Cluster: L-lactate dehydrogenase; n=5;
Bacillaceae|Rep: L-lactate dehydrogenase -
Oceanobacillus iheyensis
Length = 321
Score = 137 bits (332), Expect = 3e-31
Identities = 70/170 (41%), Positives = 100/170 (58%)
Frame = +2
Query: 353 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 532
+Y + I + AG Q+ GE+RLDLV++N + K+I+ ++ + I +IA+NPVD
Sbjct: 70 EYGDCKDADIVCICAGANQQSGETRLDLVEKNMKIFKEIVTDVMNSGFNGIFLIATNPVD 129
Query: 533 ILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVW 712
ILT SGLP HRVIGSGT LD+AR RY L + ++ + H YIIGEHGD+ +P+W
Sbjct: 130 ILTQAVISFSGLPPHRVIGSGTTLDTARLRYELGEYFHLSPKNIHAYIIGEHGDTELPLW 189
Query: 713 SAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
S I V L N+ E+ ++ NV +AY +I+ KG T G
Sbjct: 190 STATIGTVPLLTYLNR-SESYTTEDLDDIFTNVRDAAYRIIQKKGATYYG 238
Score = 37.1 bits (82), Expect = 0.60
Identities = 16/36 (44%), Positives = 22/36 (61%)
Frame = +1
Query: 214 AFSXLTQHVTHHIALVAMXAXKLKGXXMDLQHGSAF 321
AF+ + Q VT +A++ + A K G MDL HG AF
Sbjct: 24 AFALMNQGVTEELAIIDLDADKALGDVMDLNHGKAF 59
>UniRef50_UPI0000DB7267 Cluster: PREDICTED: similar to
Ecdysone-inducible gene L3 CG10160-PA; n=1; Apis
mellifera|Rep: PREDICTED: similar to Ecdysone-inducible
gene L3 CG10160-PA - Apis mellifera
Length = 368
Score = 133 bits (321), Expect = 7e-30
Identities = 56/142 (39%), Positives = 92/142 (64%)
Frame = +2
Query: 437 VQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSAR 616
V+ N V K+IIP + +++ ++L+I + P D+++Y+ WK+SG P +RV+G GT +D AR
Sbjct: 135 VKHNLKVFKKIIPAIARFAAKSVLLIVTRPADVMSYIAWKLSGFPSNRVLGIGTLIDCAR 194
Query: 617 FRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKE 796
+ +S RL +A +S IG GD +VP+WS++++ G++L D+N++IG DDPE W E
Sbjct: 195 LQDFVSRRLNVARSSVSCMTIGSQGDMAVPLWSSISVGGMKLRDINSRIGEQDDPEKWYE 254
Query: 797 LHENVVKSAYXVIKLKGYTSXG 862
+ ENV + + KG G
Sbjct: 255 IEENVKSVGKELEEKKGSCCWG 276
>UniRef50_Q98PG4 Cluster: L-lactate dehydrogenase; n=1; Mycoplasma
pulmonis|Rep: L-lactate dehydrogenase - Mycoplasma
pulmonis
Length = 315
Score = 132 bits (320), Expect = 9e-30
Identities = 71/178 (39%), Positives = 110/178 (61%), Gaps = 1/178 (0%)
Frame = +2
Query: 332 AKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILV 511
+KI++ T Y+ G+ + +V AG Q++GE+RL+++ N+ ++K I ++ K + +
Sbjct: 58 SKIRTGT-YADAKGADLLIVAAGRPQKQGETRLEMIADNSKIMKDIALEIKKSGFNGFTI 116
Query: 512 IASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHG 691
+ SNPVDIL V K++ PK +V+ SGT LD++RFR LS++ G+ T S HG++IGEHG
Sbjct: 117 VISNPVDILATVFQKVTNFPKEKVMSSGTFLDTSRFRKFLSEKTGVPTNSVHGFVIGEHG 176
Query: 692 DSSVPVWSAVNIAGVRLSD-LNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
D SV V+S + I RL D L ++ T+DD K + E K AY +I K T G
Sbjct: 177 DKSVVVFSRMQIGFSRLDDFLKSKALTEDD---LKWISEKTYKEAYEIINRKRSTYFG 231
>UniRef50_A4L2P0 Cluster: L-lactate dehydrogenase; n=4;
Lactobacillus|Rep: L-lactate dehydrogenase -
Lactobacillus reuteri
Length = 312
Score = 132 bits (319), Expect = 1e-29
Identities = 72/180 (40%), Positives = 107/180 (59%)
Frame = +2
Query: 335 KIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVI 514
KI + T Y A + + V+TAG+ ++ GE+RLDLV +NT +LK II ++K + VI
Sbjct: 63 KIYAGT-YEDAADADVVVITAGIPRKPGETRLDLVNKNTTILKSIIKPIVKSGFTGVFVI 121
Query: 515 ASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGD 694
+SNPVDILT + +ISG PK RVIG+GT+LDS R R LLS +L ++ ++GEHGD
Sbjct: 122 SSNPVDILTTIAQRISGFPKERVIGTGTSLDSMRLRVLLSKKLHLSVNVIDALMLGEHGD 181
Query: 695 SSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXGXSDC 874
+S ++ + I G L+ + TD E+ + V ++ +I KG T G + C
Sbjct: 182 TSFAAFNEITIGGKALNIITALSNTDK-----SEIEKAVHEAGSQIIANKGGTFYGIAKC 236
>UniRef50_Q81XJ7 Cluster: L-lactate dehydrogenase 3; n=13;
Firmicutes|Rep: L-lactate dehydrogenase 3 - Bacillus
anthracis
Length = 316
Score = 132 bits (318), Expect = 2e-29
Identities = 62/161 (38%), Positives = 99/161 (61%)
Frame = +2
Query: 380 ICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYVTWKI 559
I ++TAG + G+SRLD + + +++ ++ +++ D I ++ASNPVDI+TY WK+
Sbjct: 76 IVIITAGPAPKPGQSRLDTLGASAKIMESVVGGVMESGFDGIFLLASNPVDIITYQVWKL 135
Query: 560 SGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSAVNIAGVR 739
SGLP++RVIG+GT+LDS+R R +LS+ L + S HGY +GEHGDS + WS V + G
Sbjct: 136 SGLPRNRVIGTGTSLDSSRLRTILSEMLHVDPRSIHGYSLGEHGDSQMVAWSHVTVGGKP 195
Query: 740 LSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
+ + + + E+ E K+ + + K KG T G
Sbjct: 196 ILQILEEQKERFGEIDLDEIVEKTAKAGWEIYKRKGTTYYG 236
>UniRef50_A6M0Q2 Cluster: L-lactate dehydrogenase; n=1; Clostridium
beijerinckii NCIMB 8052|Rep: L-lactate dehydrogenase -
Clostridium beijerinckii NCIMB 8052
Length = 316
Score = 130 bits (315), Expect = 3e-29
Identities = 68/197 (34%), Positives = 112/197 (56%), Gaps = 4/197 (2%)
Frame = +2
Query: 284 KEX*WTCSTD-QHS*G--NAKIQ-SSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNT 451
KE W +TD QHS G +K++ +Y + I V+ A + G++RLD++++
Sbjct: 40 KEKSWAEATDLQHSLGYSGSKMRVKDGEYEECNDADIVVIAAALPYITGQTRLDMLEKAA 99
Query: 452 DVLKQIIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLL 631
++ I+P ++K I+V+ +NPVD+++Y K+SGLP +VIG+GT LDSAR +Y L
Sbjct: 100 GIMNNIVPNIMKSGFSGIIVVITNPVDVMSYYVHKLSGLPASKVIGTGTALDSARLKYHL 159
Query: 632 SDRLGIATTSCHGYIIGEHGDSSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENV 811
+D + + S H +GEHGDS + WS + + G + D+ N N + E++
Sbjct: 160 ADVMSVDPQSVHALCMGEHGDSQIIPWSQITVGGKKFLDIINDNKMRLKGFNLNSVTEDI 219
Query: 812 VKSAYXVIKLKGYTSXG 862
K AY ++ KG T+ G
Sbjct: 220 KKIAYRIVNAKGATTFG 236
>UniRef50_Q97DC6 Cluster: L-lactate dehydrogenase 2; n=1;
Clostridium acetobutylicum|Rep: L-lactate dehydrogenase
2 - Clostridium acetobutylicum
Length = 320
Score = 129 bits (311), Expect = 1e-28
Identities = 69/180 (38%), Positives = 105/180 (58%), Gaps = 2/180 (1%)
Frame = +2
Query: 329 NAKIQSSTDYSITAGSKICVVTAGVRQREGES--RLDLVQRNTDVLKQIIPQLIKYSPDT 502
N K+++ +Y A ++I V+TAG + + RL L N V I+ + KY+ D
Sbjct: 61 NVKVRAG-NYEDCADAQIIVITAGPSLKPDDKLDRLVLADTNVKVTDSIMKNICKYTKDA 119
Query: 503 ILVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIG 682
I+++ +NPVDI TY PK+++IG+GT LD+AR R ++ + + + + HGY++G
Sbjct: 120 IIIVVTNPVDIATYYCQNNFDYPKNKIIGTGTLLDTARMRKIIGKKYNVDSKNVHGYVLG 179
Query: 683 EHGDSSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
EHG SS WS VNIAG+ + LN+ I D + E+ + V S V+KLKGYTS G
Sbjct: 180 EHGGSSFTSWSDVNIAGIPFNQLND-IFKDHYKVDKDEVDKEVRDSGIEVLKLKGYTSAG 238
>UniRef50_P59390 Cluster: L-lactate dehydrogenase 2; n=8;
Lactobacillus|Rep: L-lactate dehydrogenase 2 -
Lactobacillus plantarum
Length = 309
Score = 128 bits (309), Expect = 2e-28
Identities = 70/178 (39%), Positives = 107/178 (60%)
Frame = +2
Query: 329 NAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTIL 508
NA + +Y+ + I V+TAGV ++ GESRLDL+ RNT +L+ I+ ++ +
Sbjct: 58 NATNIHTGEYADARDADIVVITAGVPRKPGESRLDLINRNTKILESIVKPVVASGFNGCF 117
Query: 509 VIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEH 688
VI+SNPVDILT +T ++SG P+HRVIG+GT+LD+AR R L+ +L +ATT+ ++GEH
Sbjct: 118 VISSNPVDILTSMTQRLSGFPRHRVIGTGTSLDTARLRVALAQKLNVATTAVDAAVLGEH 177
Query: 689 GDSSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
GDSS+ VN + ++ + T D + E+ + V +I KG T G
Sbjct: 178 GDSSI-----VNFDEIMINAQPLKTVTTVDDQFKAEIEQAVRGKGGQIISQKGATFYG 230
>UniRef50_UPI000038D9FF Cluster: COG0039: Malate/lactate
dehydrogenases; n=2; Nostoc punctiforme PCC 73102|Rep:
COG0039: Malate/lactate dehydrogenases - Nostoc
punctiforme PCC 73102
Length = 317
Score = 128 bits (308), Expect = 2e-28
Identities = 68/179 (37%), Positives = 105/179 (58%), Gaps = 1/179 (0%)
Frame = +2
Query: 335 KIQSSTDYSITAGSKICV-VTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILV 511
+I S Y A S I + VTAGV+ + G++RLD + N ++++ I +L + +P++I++
Sbjct: 61 EIIPSNQYEDLADSDIIIIVTAGVQPKLGQTRLDTLSDNAEIIRSTIKELDRVAPNSIVI 120
Query: 512 IASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHG 691
I SNPVD+LT + S ++ + GSGT LD+AR RY L +L +A H Y+IGEHG
Sbjct: 121 IISNPVDVLTRIAQATSTRAENLIFGSGTVLDTARLRYQLGKQLNVAKQDIHAYVIGEHG 180
Query: 692 DSSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXGXS 868
DS VWS+ I G+ L++ G + + +E + K Y + + KGYTS G S
Sbjct: 181 DSQFVVWSSAFIGGILLTEFPIPQGATLE-QIQQEYAQLTRKRGYNIFERKGYTSYGIS 238
>UniRef50_Q0UX88 Cluster: L-lactate dehydrogenase; n=2;
Phaeosphaeria nodorum|Rep: L-lactate dehydrogenase -
Phaeosphaeria nodorum (Septoria nodorum)
Length = 326
Score = 127 bits (306), Expect = 4e-28
Identities = 67/178 (37%), Positives = 107/178 (60%)
Frame = +2
Query: 329 NAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTIL 508
+ K++S T + + I V+TAG +Q+ GESRL L+ RN ++L I + S T+L
Sbjct: 59 STKVRSGT-HQEAGQADIVVITAGAKQKTGESRLSLLTRNLNILSSIFDSMKPISAHTVL 117
Query: 509 VIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEH 688
++ +NPVDIL Y +SGLP+++V+G+GT+LDSAR R +L+ + G++ +S Y++GEH
Sbjct: 118 LLVANPVDILVYFARMMSGLPENQVLGTGTSLDSARLRGVLAGKAGVSPSSIDAYVLGEH 177
Query: 689 GDSSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
GDS WS+ A + + L +G + E +E+ +A +I KG TS G
Sbjct: 178 GDSQFVAWSS---ASIGTTPLRLALGDELTDEFKEEVAMKTRGAAGAIIAAKGCTSYG 232
>UniRef50_A2SSY4 Cluster: L-lactate dehydrogenase; n=3;
Methanomicrobiales|Rep: L-lactate dehydrogenase -
Methanocorpusculum labreanum (strain ATCC 43576 / DSM
4855 / Z)
Length = 319
Score = 126 bits (305), Expect = 6e-28
Identities = 66/181 (36%), Positives = 104/181 (57%)
Frame = +2
Query: 329 NAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTIL 508
N ++ T GS I V+T+GV ++ ++RLDL N ++K Q+ + +P+ IL
Sbjct: 59 NTRVTFGTTPKELRGSDIIVLTSGVPRKATQTRLDLALENARIVKVFAEQVGRMAPEAIL 118
Query: 509 VIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEH 688
++ +NPVDI+T V K SG+ HRV G GT+LDS R + L++ + + H IIGEH
Sbjct: 119 LVVTNPVDIMTTVALKYSGMMPHRVFGLGTHLDSMRLKACLAEFFNVHVSEIHTRIIGEH 178
Query: 689 GDSSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXGXS 868
GD+ VP+WSA + G++ ++N +G P +E+ + V S +I+ KG T G
Sbjct: 179 GDTMVPMWSATTVGGIQ---IDNLLGVAKLPR--EEMIQRVKSSGSYIIEAKGATVYGPG 233
Query: 869 D 871
D
Sbjct: 234 D 234
>UniRef50_Q9P4B6 Cluster: L-lactate dehydrogenase A; n=48; Rhizopus
oryzae|Rep: L-lactate dehydrogenase A - Rhizopus oryzae
(Rhizopus delemar)
Length = 320
Score = 126 bits (304), Expect = 8e-28
Identities = 65/165 (39%), Positives = 94/165 (56%)
Frame = +2
Query: 380 ICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYVTWKI 559
I V+TAG +QREGE R L++RN VL+ II + PD ++++ +NPVDILT++ +
Sbjct: 73 IVVITAGAKQREGEPRTKLIERNFRVLQSIIGGMQPIRPDAVILVVANPVDILTHIAKTL 132
Query: 560 SGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSAVNIAGVR 739
SGLP ++VIGSGT LD+ R R L D + S H +++GEHGDS + W A +I G
Sbjct: 133 SGLPPNQVIGSGTYLDTTRLRVHLGDVFDVNPQSVHAFVLGEHGDSQMIAWEAASIGGQP 192
Query: 740 LSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXGXSDC 874
L+ D + + + A +I+LKG T G C
Sbjct: 193 LTSFPEFAKLDK-----TAISKAISGKAMEIIRLKGATFYGIGAC 232
>UniRef50_Q03BE6 Cluster: L-lactate dehydrogenase; n=1;
Lactobacillus casei ATCC 334|Rep: L-lactate
dehydrogenase - Lactobacillus casei (strain ATCC 334)
Length = 312
Score = 126 bits (303), Expect = 1e-27
Identities = 64/161 (39%), Positives = 97/161 (60%)
Frame = +2
Query: 380 ICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYVTWKI 559
I V+TAG+ Q+ G++RL L+ N ++K+I ++ + +++ASNPVD+L + +
Sbjct: 74 IIVITAGIAQKPGQTRLQLLAINAKIMKEITHNIMASGFNGFILVASNPVDVLAELVLQE 133
Query: 560 SGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSAVNIAGVR 739
SGLP+++V+GSGT LDSAR R + R + HGYI+GEHGDS PVW NI G
Sbjct: 134 SGLPRNQVLGSGTALDSARLRSEIGLRYNVDARIVHGYIMGEHGDSEFPVWDYTNIGGKP 193
Query: 740 LSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
+ D I D ++ ++ E V +AY +I+ KG T G
Sbjct: 194 ILD---WIPKDRQDKDLPDISERVKTAAYGIIEKKGATFYG 231
>UniRef50_O67655 Cluster: Malate dehydrogenase 1; n=3; Bacteria|Rep:
Malate dehydrogenase 1 - Aquifex aeolicus
Length = 335
Score = 125 bits (301), Expect = 2e-27
Identities = 56/132 (42%), Positives = 85/132 (64%)
Frame = +2
Query: 356 YSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDI 535
Y GS I V+TAG +R G SR DL++ N ++ I ++ +Y+PD I+++ +NPVD+
Sbjct: 80 YEPLEGSDIVVITAGFPRRPGMSREDLLEANIRIISVIADRIKRYAPDAIVIVVTNPVDV 139
Query: 536 LTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 715
+TYV +K+ PK+RV+G LDSARF+ +S+ L ++ H Y+IG HGD VP+ S
Sbjct: 140 MTYVAYKLLNFPKNRVMGMAGVLDSARFKTFISEELMVSPKDIHAYVIGGHGDEMVPLIS 199
Query: 716 AVNIAGVRLSDL 751
N+ G+ L DL
Sbjct: 200 ISNVGGIPLKDL 211
>UniRef50_Q8TWG5 Cluster: Malate dehydrogenase; n=2;
Euryarchaeota|Rep: Malate dehydrogenase - Methanopyrus
kandleri
Length = 317
Score = 123 bits (296), Expect = 7e-27
Identities = 52/119 (43%), Positives = 86/119 (72%)
Frame = +2
Query: 380 ICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYVTWKI 559
+ V+TAG+ ++ G++RLDL + N ++K+ + + + +P+ I+++ +NPVD+LTYV K+
Sbjct: 76 VIVMTAGIPRKPGQTRLDLTKDNAAIIKKYLEGVAEENPEAIVLVVTNPVDVLTYVALKV 135
Query: 560 SGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSAVNIAGV 736
SGLPK+RVIG GT+LDS RF+ L++ + + H IIGEHGD+ VPV S+ ++ G+
Sbjct: 136 SGLPKNRVIGLGTHLDSMRFKVLIAKHFNVHMSEVHTRIIGEHGDTMVPVISSTSVGGI 194
>UniRef50_Q6KIP9 Cluster: L-lactate dehydrogenase; n=1; Mycoplasma
mobile|Rep: L-lactate dehydrogenase - Mycoplasma mobile
Length = 318
Score = 122 bits (295), Expect = 9e-27
Identities = 60/170 (35%), Positives = 100/170 (58%)
Frame = +2
Query: 353 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 532
+YS + V+TAG Q+ GE+RL++V N ++ I + K + ++ +NPVD
Sbjct: 67 EYSDLKDYDVVVITAGRPQKPGETRLEMVADNAKIMSNIAKNIKKSGFKGVSIVVANPVD 126
Query: 533 ILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVW 712
++T++ +G K+RVI SGT+LDSAR R+ +S +L + S +++GEHGDSSV V+
Sbjct: 127 VMTFIYQHETGFDKNRVISSGTSLDSARLRFEISKKLKVHPKSVQAFVLGEHGDSSVSVY 186
Query: 713 SAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
SA ++G +++ + G + +++H V K AY +I KG T G
Sbjct: 187 SAATVSGKSFNEIVKERGI--SKKELEDMHTTVYKKAYEIINRKGSTYFG 234
>UniRef50_Q8YJE7 Cluster: Malate dehydrogenase; n=98; Bacteria|Rep:
Malate dehydrogenase - Brucella melitensis
Length = 320
Score = 121 bits (292), Expect = 2e-26
Identities = 57/150 (38%), Positives = 89/150 (59%)
Frame = +2
Query: 329 NAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTIL 508
+AK + DY+ G+ + +VTAGV ++ G SR DL+ N V++Q+ + KY+P+ +
Sbjct: 57 DAKFTGANDYAAIEGADVVIVTAGVPRKPGMSRDDLLGINLKVMEQVGAGIKKYAPEAFV 116
Query: 509 VIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEH 688
+ +NP+D + + K SGLP H+V+G LDSARFRY LS+ ++ +++G H
Sbjct: 117 ICITNPLDAMVWALQKFSGLPAHKVVGMAGVLDSARFRYFLSEEFNVSVEDVTAFVLGGH 176
Query: 689 GDSSVPVWSAVNIAGVRLSDLNNQIGTDDD 778
GDS VP+ +AG+ LSDL T D
Sbjct: 177 GDSMVPLARYSTVAGIPLSDLVKMGWTSQD 206
>UniRef50_A3EWH3 Cluster: Malate/lactate dehydrogenase; n=1;
Leptospirillum sp. Group II UBA|Rep: Malate/lactate
dehydrogenase - Leptospirillum sp. Group II UBA
Length = 320
Score = 121 bits (291), Expect = 3e-26
Identities = 51/138 (36%), Positives = 89/138 (64%)
Frame = +2
Query: 329 NAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTIL 508
+ +I S +Y GS + VVTAG ++ G SR DL+ +N D++ ++ ++ K++PD+++
Sbjct: 60 DTRIVGSGNYETIEGSSVVVVTAGFSRKPGMSREDLLHKNGDIMIEVAEKIRKHAPDSVV 119
Query: 509 VIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEH 688
++ +NP+D++ Y+ WK++G P+ RVIG G LDS+RF Y +S+ + ++ ++G H
Sbjct: 120 IMVTNPMDLMAYILWKVTGFPRERVIGMGGALDSSRFAYFVSEVTNTSVSNIQTMVMGGH 179
Query: 689 GDSSVPVWSAVNIAGVRL 742
GD VP+ IAGV L
Sbjct: 180 GDDMVPLLEFSTIAGVSL 197
>UniRef50_Q6F0L9 Cluster: L-lactate dehydrogenase; n=6;
Mollicutes|Rep: L-lactate dehydrogenase - Mesoplasma
florum (Acholeplasma florum)
Length = 317
Score = 120 bits (289), Expect = 5e-26
Identities = 66/175 (37%), Positives = 100/175 (57%), Gaps = 2/175 (1%)
Frame = +2
Query: 356 YSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDI 535
Y + + V+TAG QR GE+RL+L+ N+ ++K I + + + VIASNP D+
Sbjct: 68 YEDCKDADLIVITAGRPQRPGETRLELIADNSRIMKGIAEAIKASGFNGVTVIASNPCDV 127
Query: 536 LTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 715
LT V +++G +H V+G+GT LDSAR R L++++L +A S + YI+GEHGDSSV +S
Sbjct: 128 LTTVYQQVTGYDEHSVVGAGTTLDSARLRRLVAEKLNVAPKSVNAYIMGEHGDSSVAAYS 187
Query: 716 AVNIAGVRLSD--LNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXGXSDC 874
+ G +S +I D E W ++ AY +I+ KG T G C
Sbjct: 188 KATVMGQPISKYLAEGKITEADLEECW----TRAIRMAYEIIERKGATYYGIGVC 238
>UniRef50_Q18WQ6 Cluster: Malate dehydrogenase, NAD-dependent; n=2;
Desulfitobacterium hafniense|Rep: Malate dehydrogenase,
NAD-dependent - Desulfitobacterium hafniense (strain
DCB-2)
Length = 320
Score = 120 bits (288), Expect = 7e-26
Identities = 51/141 (36%), Positives = 90/141 (63%)
Frame = +2
Query: 329 NAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTIL 508
+ ++ ++DY T S + V+TAG+ ++ G SR +L N ++ ++ Q++++SP++ L
Sbjct: 57 SVRVTGTSDYQDTLDSDVVVITAGIARKPGMSRNELCDINAGIVTHVVRQVVQHSPNSTL 116
Query: 509 VIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEH 688
+I SNPVDI+TYV +K SG ++R+IG LDSARFRY ++ L ++ G+++G H
Sbjct: 117 IILSNPVDIMTYVAFKESGFKRNRIIGQSGVLDSARFRYFVASELKVSAEDVTGFVLGVH 176
Query: 689 GDSSVPVWSAVNIAGVRLSDL 751
GD VP+ ++ G+ + L
Sbjct: 177 GDDMVPLVRYCSVHGIPIQQL 197
>UniRef50_Q8ZVB2 Cluster: Malate dehydrogenase; n=14;
Thermoprotei|Rep: Malate dehydrogenase - Pyrobaculum
aerophilum
Length = 309
Score = 120 bits (288), Expect = 7e-26
Identities = 60/170 (35%), Positives = 102/170 (60%)
Frame = +2
Query: 347 STDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 526
S +Y GS + +VTAG+ ++ G +R L++ N ++ +I ++ KY+PD+I+++ +NP
Sbjct: 60 SNEYKDIEGSDLIIVTAGLPRKPGMTREQLLEANAKIVAEIGREIKKYAPDSIVILTTNP 119
Query: 527 VDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVP 706
+D +TYV WK +G P+ RVIG LD+ R + + +LGI+ S ++G+HG+S P
Sbjct: 120 LDAMTYVMWKATGFPRERVIGFSGVLDAGRLAFYAAKKLGISPASILPIVLGQHGESMFP 179
Query: 707 VWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTS 856
V S + GV LS L + E KE+ E VK+ + +L+G++S
Sbjct: 180 VPSKSYVHGVPLSKLLTE-------EQLKEVVEETVKAGARITELRGFSS 222
>UniRef50_Q4L941 Cluster: L-lactate dehydrogenase; n=1;
Staphylococcus haemolyticus JCSC1435|Rep: L-lactate
dehydrogenase - Staphylococcus haemolyticus (strain
JCSC1435)
Length = 318
Score = 119 bits (286), Expect = 1e-25
Identities = 62/164 (37%), Positives = 97/164 (59%), Gaps = 1/164 (0%)
Frame = +2
Query: 380 ICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYVTWKI 559
I V+ A + +GE+RL L++ N D+ +I +++ D V+ SNPVDI++YV ++
Sbjct: 74 IVVICASAKLAKGETRLKLLEDNVDIFVPMIQRIVDSGFDGYFVLPSNPVDIMSYVVKRV 133
Query: 560 SGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSAVNIAGVR 739
S PK+++IGSGT+LD+ARF++ LS +A + IIGEHGDS V VWS IAG
Sbjct: 134 SNFPKNKIIGSGTSLDTARFQFFLSREFDVAPNQVYAPIIGEHGDSQVAVWSHAQIAGEP 193
Query: 740 LSDLNNQIGTDDDPENWK-ELHENVVKSAYXVIKLKGYTSXGXS 868
+ DL + ++ + E +K + + Y + KG T+ G S
Sbjct: 194 VLDL---LPSNTNLEAFKTSISNRTTQIGYDIYVRKGTTNFGIS 234
>UniRef50_P47698 Cluster: L-lactate dehydrogenase; n=2;
Mycoplasma|Rep: L-lactate dehydrogenase - Mycoplasma
genitalium
Length = 312
Score = 119 bits (286), Expect = 1e-25
Identities = 62/174 (35%), Positives = 104/174 (59%), Gaps = 1/174 (0%)
Frame = +2
Query: 353 DYSITAGSKICVVTAGVRQREG-ESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 529
+YS ++AG Q++G E+RL L++ N +++K I ++ K + + +IASNPV
Sbjct: 65 EYSQLKDYDFIFISAGRPQKQGGETRLQLLEGNVEIMKSIAKEIKKSGFNGVTLIASNPV 124
Query: 530 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPV 709
DI++Y K++G ++VIGSGT LDSAR RY ++ + +++ Y+IGEHGDSSV +
Sbjct: 125 DIMSYTYLKVTGFEPNKVIGSGTLLDSARLRYAIATKYQMSSKDVQAYVIGEHGDSSVSI 184
Query: 710 WSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXGXSD 871
S+ IAG+ L + D + + E+ + + + AY +I+ KG T G +
Sbjct: 185 ISSAKIAGLSLKHFSK---ASDIEKEFGEIDQFIRRRAYEIIERKGATFYGIGE 235
>UniRef50_A7I5J9 Cluster: L-lactate dehydrogenase precursor; n=1;
Candidatus Methanoregula boonei 6A8|Rep: L-lactate
dehydrogenase precursor - Methanoregula boonei (strain
6A8)
Length = 332
Score = 118 bits (285), Expect = 2e-25
Identities = 56/141 (39%), Positives = 87/141 (61%)
Frame = +2
Query: 329 NAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTIL 508
N ++ +T AGS I V+TAG + G++RLDL N ++ + + +PDT +
Sbjct: 59 NIRVTWTTSLKDVAGSDIVVITAGTPRGPGQNRLDLALGNARIIAPMARTIGTIAPDTKI 118
Query: 509 VIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEH 688
++ +NPVD++T V K SGL ++V G GT+LDS R + L++ + + H IIGEH
Sbjct: 119 IMVTNPVDVMTCVALKYSGLKPNQVFGLGTHLDSMRLKSLIASYFKVHVSEVHTRIIGEH 178
Query: 689 GDSSVPVWSAVNIAGVRLSDL 751
GDS VP+WSA I G+++S+L
Sbjct: 179 GDSMVPLWSATTIGGIKISNL 199
>UniRef50_Q64P62 Cluster: Malate dehydrogenase; n=28;
Bacteroidetes|Rep: Malate dehydrogenase - Bacteroides
fragilis
Length = 313
Score = 118 bits (285), Expect = 2e-25
Identities = 56/136 (41%), Positives = 86/136 (63%), Gaps = 1/136 (0%)
Frame = +2
Query: 347 STDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 526
+ DY+ TA S + V+T+G+ ++ G +R +L+ N ++K + L+KYSP+ I+V+ SNP
Sbjct: 63 TNDYAQTANSDVVVITSGIPRKPGMTREELIGVNAGIVKSVAENLLKYSPNAIIVVISNP 122
Query: 527 VDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSS-V 703
+D +TY+ K GLPK+RVIG G LDS+RF+Y LS LG G +IG HGD++ +
Sbjct: 123 MDTMTYLALKSLGLPKNRVIGMGGALDSSRFKYFLSQALGCNANEVEGMVIGGHGDTTMI 182
Query: 704 PVWSAVNIAGVRLSDL 751
P+ G +S L
Sbjct: 183 PLARLATYKGQPVSTL 198
>UniRef50_A1HSK3 Cluster: Lactate/malate dehydrogenase; n=1;
Thermosinus carboxydivorans Nor1|Rep: Lactate/malate
dehydrogenase - Thermosinus carboxydivorans Nor1
Length = 303
Score = 118 bits (283), Expect = 3e-25
Identities = 60/163 (36%), Positives = 99/163 (60%)
Frame = +2
Query: 365 TAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTY 544
TAG+ I V+TAG+ ++ E R+ L+ RN ++ ++ Q + YSP+ I+ + +NP+D++T
Sbjct: 65 TAGADIVVITAGIPRKADEPRVLLLSRNAALIADLVRQAVHYSPNCIIFMVTNPLDVMTQ 124
Query: 545 VTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSAVN 724
+ +++SGLP +RVIG GT LD+AR+R L+ Y++GEHG++ V + S +
Sbjct: 125 LAYQVSGLPANRVIGMGTVLDTARYRSYLAVAFDADARDIDAYVVGEHGETMVCLTSQIT 184
Query: 725 IAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYT 853
+ GV L+ L D + ENVV+++ VI LKG T
Sbjct: 185 VRGVPLTALPGY-----DQAKLAPIIENVVQASSQVIALKGGT 222
>UniRef50_Q979N9 Cluster: Malate dehydrogenase; n=4;
Thermoplasmatales|Rep: Malate dehydrogenase -
Thermoplasma volcanium
Length = 325
Score = 117 bits (282), Expect = 3e-25
Identities = 53/135 (39%), Positives = 84/135 (62%)
Frame = +2
Query: 347 STDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 526
S++Y GS + VVTAG+ ++ G SR DL +N +++ + + KYSPD+I+V+ SNP
Sbjct: 68 SSNYKNMEGSDVIVVTAGMARKPGMSREDLFDKNVEIIADVSKNIKKYSPDSIIVVVSNP 127
Query: 527 VDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVP 706
DI+ Y KISG+ R++G G +LDS+RFR L+ L ++ + ++IG HGD VP
Sbjct: 128 ADIMAYALQKISGVDPQRIMGLGGSLDSSRFRTFLAKELDVSVEDVNAFVIGGHGDDMVP 187
Query: 707 VWSAVNIAGVRLSDL 751
++AG+ + L
Sbjct: 188 FIRYSSVAGIPIEKL 202
>UniRef50_Q92BI0 Cluster: L-lactate dehydrogenase 2; n=18;
Bacteria|Rep: L-lactate dehydrogenase 2 - Listeria
innocua
Length = 311
Score = 116 bits (280), Expect = 6e-25
Identities = 61/162 (37%), Positives = 99/162 (61%), Gaps = 1/162 (0%)
Frame = +2
Query: 380 ICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYVTWKI 559
+ VTAG +EG++RLD ++ + ++ I+P+++K I +IA+NP DI+TY WK+
Sbjct: 76 VITVTAGPL-KEGQTRLDELRSTSRIVASIVPEMMKGGFKGIFLIATNPCDIITYQVWKL 134
Query: 560 SGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSAVNIAGVR 739
SGLP+ +V+G+G LD+ R R LL+++L IA S +I+GEHGDS PVWS +I G
Sbjct: 135 SGLPREQVLGTGVWLDTTRLRRLLAEKLDIAAQSIDAFILGEHGDSQFPVWSHSSIYGKP 194
Query: 740 LSDLN-NQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
+++ + ++G D K + E + + + KG T G
Sbjct: 195 VNEYSMEKLGESLD---LKLIGETARDTGFEIYHQKGCTEYG 233
>UniRef50_Q3ZZJ7 Cluster: Malate dehydrogenase; n=5; cellular
organisms|Rep: Malate dehydrogenase - Dehalococcoides
sp. (strain CBDB1)
Length = 307
Score = 116 bits (278), Expect = 1e-24
Identities = 54/138 (39%), Positives = 85/138 (61%)
Frame = +2
Query: 338 IQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIA 517
I S DY+ TAGS+I V+TAG+ ++ G +R +L+ N ++ ++ +KYSP+ LV+
Sbjct: 58 ITGSNDYAQTAGSEIVVITAGIARKPGMTREELLAINQKIMTDVVSNCLKYSPEATLVVV 117
Query: 518 SNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDS 697
SNPVD +TY+ WK+SGLP+ RV+G LD R ++ LG+ ++ ++GEHG S
Sbjct: 118 SNPVDTMTYLAWKLSGLPRKRVVGLSGVLDGGRLATFVARELGVNPSAVSPCVMGEHGGS 177
Query: 698 SVPVWSAVNIAGVRLSDL 751
V + + G LS+L
Sbjct: 178 MVVMSRFTLVNGKPLSEL 195
>UniRef50_Q1FID3 Cluster: L-lactate dehydrogenase precursor; n=1;
Clostridium phytofermentans ISDg|Rep: L-lactate
dehydrogenase precursor - Clostridium phytofermentans
ISDg
Length = 325
Score = 114 bits (274), Expect = 3e-24
Identities = 57/172 (33%), Positives = 100/172 (58%), Gaps = 2/172 (1%)
Frame = +2
Query: 353 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 532
DY+ + I V+TAG + G+SRLD + + D++ I+ ++K + I ++ +NPVD
Sbjct: 69 DYTDCKDADIVVITAGPPPKPGQSRLDTLGLSADIVSTIVEPVMKSGFNGIFLVVTNPVD 128
Query: 533 ILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVW 712
+ +++SGLPK +V+G+GT +DSAR ++ + D L + S Y +GEHGDS + W
Sbjct: 129 SIAQYVYQLSGLPKQQVLGTGTAIDSARLKHFIGDILHVDPRSIQAYTMGEHGDSQMCPW 188
Query: 713 SAVNIAGVRLSDL--NNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
S V + G + D+ +N+ +D D + E+ V + + ++ +KG T G
Sbjct: 189 SLVTVGGKNIMDIVRDNKEYSDID---FNEILYKVTRVGFDILSVKGTTCYG 237
>UniRef50_A4A2L6 Cluster: L-lactate dehydrogenase; n=4;
Bacteria|Rep: L-lactate dehydrogenase - Blastopirellula
marina DSM 3645
Length = 313
Score = 114 bits (274), Expect = 3e-24
Identities = 66/173 (38%), Positives = 90/173 (52%), Gaps = 2/173 (1%)
Frame = +2
Query: 335 KIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIK--YSPDTIL 508
++ +S Y S + +TAG+R++ ESRLDL+ RN D+ I+ + D I
Sbjct: 56 QVITSGGYEHIPDSDVICITAGLRRKPDESRLDLINRNVDLFLSILDSVKSAGVKKDAIC 115
Query: 509 VIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEH 688
+ SNPVDILTY+ + LP RVIG GT LD+ RFR L++ + + T I+GEH
Sbjct: 116 FVVSNPVDILTYLAAQRLNLPTSRVIGLGTQLDTIRFRALIAQEMKLPPTQVKALILGEH 175
Query: 689 GDSSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKG 847
GDS +PVWSA + G+ L P EL S VIK KG
Sbjct: 176 GDSMLPVWSAATVNGLPLDKFPGW-----TPNKATELFTRTRGSGAEVIKKKG 223
>UniRef50_A7DRG3 Cluster: Lactate/malate dehydrogenase; n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep:
Lactate/malate dehydrogenase - Candidatus Nitrosopumilus
maritimus SCM1
Length = 304
Score = 111 bits (268), Expect = 2e-23
Identities = 56/175 (32%), Positives = 103/175 (58%)
Frame = +2
Query: 329 NAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTIL 508
+ +++ S ++ GS I VV AG ++ G +R+DL++ N ++K ++ + KY+ D+++
Sbjct: 54 DVEVKGSNNFEDMKGSNIVVVVAGSGRKPGMTRMDLLKINASIVKSVVENVKKYADDSMI 113
Query: 509 VIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEH 688
+ +NP+D + Y+T+K+SG + RV G G LD +RFR + + G + S +IGEH
Sbjct: 114 IPVTNPLDPMAYITYKVSGFDRSRVFGMGGMLDLSRFRQFIHEATGHSRDSIRALVIGEH 173
Query: 689 GDSSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYT 853
G++ +P+ +++G+ L L + E +EL +N + A VI+LKG T
Sbjct: 174 GENMLPLPRFSSVSGIPLPSLLPK-------EKLEELVQNTKQVAAKVIELKGAT 221
>UniRef50_Q9EVR0 Cluster: L-lactate dehydrogenase; n=1; Selenomonas
ruminantium|Rep: L-lactate dehydrogenase - Selenomonas
ruminantium
Length = 318
Score = 111 bits (267), Expect = 2e-23
Identities = 54/181 (29%), Positives = 105/181 (58%), Gaps = 4/181 (2%)
Frame = +2
Query: 353 DYSITAGSKICVVTAGVRQREGES--RLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 526
DY + I V+TAG R GE+ RL L N ++ ++ +++K + + ++++ +NP
Sbjct: 67 DYEDCKDANIIVITAGPSIRPGETPDRLKLAGTNAKIMSSVMGEIVKRTKEAMIIMITNP 126
Query: 527 VDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVP 706
+D+ TYV P++ ++G+GT L++ RFR +L+D+ + + +GY++GEHG+++
Sbjct: 127 LDVATYVVSTQFDYPRNLILGTGTMLETYRFRRILADKYQVDPKNINGYVLGEHGNAAFV 186
Query: 707 VWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG--XSDCRW 880
WS AG + DL+ + + + + + +V+ AY VI KG+T+ G + CR+
Sbjct: 187 AWSTTGCAGFPIDDLDEYFHRTEKLSH-EAVEQELVQVAYDVINKKGFTNTGIAMAACRF 245
Query: 881 L 883
+
Sbjct: 246 I 246
>UniRef50_A0RXX8 Cluster: Malate/L-lactate dehydrogenase; n=1;
Cenarchaeum symbiosum|Rep: Malate/L-lactate
dehydrogenase - Cenarchaeum symbiosum
Length = 302
Score = 110 bits (264), Expect = 5e-23
Identities = 57/175 (32%), Positives = 102/175 (58%)
Frame = +2
Query: 329 NAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTIL 508
+ +++ S DYS GS I VV AG ++ G +R+DL++ N ++K ++ ++ +++ D+++
Sbjct: 54 DTEVRGSNDYSDMEGSDIVVVVAGAGRKPGMTRMDLLKINAGIVKGVVEKVKEHAKDSMI 113
Query: 509 VIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEH 688
+ +NP+D +TY+ +K SG K+RV G G LD +RFR + + G + S ++GEH
Sbjct: 114 IPVTNPLDPITYIAYKTSGFEKNRVFGMGGMLDLSRFRQFIHEATGYSRDSIRALVMGEH 173
Query: 689 GDSSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYT 853
G++ +P+ ++G+ L L + E EL + K A VI+LKG T
Sbjct: 174 GENMLPLPRFSTVSGIPLLSLIS-------AEKAAELVRDTKKVAAKVIELKGAT 221
>UniRef50_Q9CGG8 Cluster: L-lactate dehydrogenase 3; n=3;
Lactococcus lactis|Rep: L-lactate dehydrogenase 3 -
Lactococcus lactis subsp. lactis (Streptococcus lactis)
Length = 323
Score = 110 bits (264), Expect = 5e-23
Identities = 57/175 (32%), Positives = 98/175 (56%), Gaps = 3/175 (1%)
Frame = +2
Query: 347 STDYSITAGSKICVVTAGVRQR---EGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIA 517
+ DYS + + I V++A + RL L++ ++++ I + + D I ++A
Sbjct: 66 AADYSDVSDADIVVLSANAPSATFGKNPDRLQLLENKVEMIRDITRKTMDAGFDGIFLVA 125
Query: 518 SNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDS 697
SNPVD+L V ++SGLPKHRVIG+GT L+++R R +++++L I S HGY++ EHG S
Sbjct: 126 SNPVDVLAQVVAEVSGLPKHRVIGTGTLLETSRMRQIVAEKLQINPKSIHGYVLAEHGKS 185
Query: 698 SVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
S WS V + + L+ + + P + E+ + + + + KG TS G
Sbjct: 186 SFAAWSNVTVGAIPLTTWLKKYPNPEFP-TFDEIDQEIREVGLDIFMQKGNTSYG 239
>UniRef50_A4BB89 Cluster: Lactate dehydrogenase; n=2;
Gammaproteobacteria|Rep: Lactate dehydrogenase -
Reinekea sp. MED297
Length = 319
Score = 109 bits (263), Expect = 7e-23
Identities = 58/179 (32%), Positives = 99/179 (55%), Gaps = 1/179 (0%)
Frame = +2
Query: 329 NAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTIL 508
N ++++ DYS+ + I V+TAG + +EG++R DL + N+ + I ++ +P+ IL
Sbjct: 56 NIRLRAGDDYSLLTDADIVVITAGAQIKEGQTRDDLAEINSRITVDIAQKIETVAPNAIL 115
Query: 509 VIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEH 688
++ +NP DI TY + +G P RVI +G +D+AR L+S+++ + + GYI+GEH
Sbjct: 116 LVVTNPCDIATYFITQNTGFPADRVISAGCIIDTARLMKLVSEKVDVDPKNVSGYILGEH 175
Query: 689 GDSSVPVWSAVNIAGVRLSDLNNQIGTDD-DPENWKELHENVVKSAYXVIKLKGYTSXG 862
G W V +AG + G D DP+ L E V ++ + + K K T+ G
Sbjct: 176 GSHCFMPWGLVGVAGQPIDYYCQHNGFDAIDPQT---LLEEVKQAGFEIFKRKHNTTHG 231
>UniRef50_Q8IX04 Cluster: Ubiquitin-conjugating enzyme E2 variant 3;
n=15; Euteleostomi|Rep: Ubiquitin-conjugating enzyme E2
variant 3 - Homo sapiens (Human)
Length = 471
Score = 109 bits (263), Expect = 7e-23
Identities = 52/126 (41%), Positives = 80/126 (63%)
Frame = +2
Query: 338 IQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIA 517
++ S D S +A SK+ + T +S LD+VQ N D+ + ++P L YS ++L++A
Sbjct: 234 VEISKDLSASAHSKVVIFTVN-SLGSSQSYLDVVQSNVDMFRALVPALGHYSQHSVLLVA 292
Query: 518 SNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDS 697
S PV+I+TYVTWK+S P +RVIG G NLDS R +Y++++ L T+ ++IGE G+
Sbjct: 293 SQPVEIMTYVTWKLSTFPANRVIGIGCNLDSQRLQYIITNVLKAQTSGKEVWVIGEQGED 352
Query: 698 SVPVWS 715
V WS
Sbjct: 353 KVLTWS 358
>UniRef50_Q07841 Cluster: Malate dehydrogenase; n=7;
Halobacteriaceae|Rep: Malate dehydrogenase - Haloarcula
marismortui (Halobacterium marismortui)
Length = 304
Score = 109 bits (262), Expect = 9e-23
Identities = 62/169 (36%), Positives = 95/169 (56%)
Frame = +2
Query: 356 YSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDI 535
Y TAGS + V+TAG+ ++ G++R+DL N +++ I L +++ D I + SNPVD+
Sbjct: 66 YEDTAGSDVVVITAGIPRQPGQTRIDLAGDNAPIMEDIQSSLDEHNDDYISLTTSNPVDL 125
Query: 536 LTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 715
L ++ + +VIG G LDSARFRY+LS+ + G I+GEHGD+ VPV+S
Sbjct: 126 LNRHLYEAGDRSREQVIGFGGRLDSARFRYVLSEEFDAPVQNVEGTILGEHGDAQVPVFS 185
Query: 716 AVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
V + G + + D+ + +L E SA VI+ KG T G
Sbjct: 186 KVRVDGT-----DPEFSGDEKEQLLGDLQE----SAMDVIERKGATEWG 225
>UniRef50_O67581 Cluster: Malate dehydrogenase 2; n=1; Aquifex
aeolicus|Rep: Malate dehydrogenase 2 - Aquifex aeolicus
Length = 334
Score = 109 bits (262), Expect = 9e-23
Identities = 51/115 (44%), Positives = 74/115 (64%)
Frame = +2
Query: 371 GSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYVT 550
GS I V+TAG+ +REG SR DL+ N +LK+ + +Y+ D+I+++ SNPVD LTY T
Sbjct: 88 GSDIVVITAGIPRREGMSREDLLYENLKILKKFTDAIKEYAKDSIIIVVSNPVDTLTYAT 147
Query: 551 WKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 715
K++G RVIG LDSARF+ + +++GI+ ++G HGD VPV S
Sbjct: 148 IKLTGFEPRRVIGMAGVLDSARFKNFVKEKIGISNADIRTLVLGTHGDLMVPVTS 202
>UniRef50_O08349 Cluster: Malate dehydrogenase; n=1; Archaeoglobus
fulgidus|Rep: Malate dehydrogenase - Archaeoglobus
fulgidus
Length = 294
Score = 109 bits (261), Expect = 1e-22
Identities = 62/176 (35%), Positives = 99/176 (56%)
Frame = +2
Query: 335 KIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVI 514
KI DYS+ GS+I VVTAG+ ++ G +RLDL +N ++K I ++++ +P++ +++
Sbjct: 57 KIVGGADYSLLKGSEIIVVTAGLARKPGMTRLDLAHKNAGIIKDIAKKIVENAPESKILV 116
Query: 515 ASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGD 694
+NP+D++TY+ WK SG P++ V G G LDS R + L + A +IIGEHGD
Sbjct: 117 VTNPMDVMTYIMWKESGKPRNEVFGMGNQLDSQRLKERLYN--AGARNIRRAWIIGEHGD 174
Query: 695 SSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
S S L+D + ++ +W+ + +V A VIK KG T G
Sbjct: 175 SMFVAKS--------LADFDGEV-------DWEAVENDVRFVAAEVIKRKGATIFG 215
>UniRef50_Q185V1 Cluster: L-lactate dehydrogenase; n=3;
Clostridium|Rep: L-lactate dehydrogenase - Clostridium
difficile (strain 630)
Length = 322
Score = 108 bits (260), Expect = 2e-22
Identities = 51/118 (43%), Positives = 75/118 (63%)
Frame = +2
Query: 398 GVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKH 577
G +R+ +RLDL++ ++K I+ ++ D I V+ SNPVD++T W+ SG PK+
Sbjct: 87 GPLRRQNTTRLDLLRPTIGMIKSIVKPIVDSGFDGIFVVISNPVDVVTNYIWEKSGFPKN 146
Query: 578 RVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSAVNIAGVRLSDL 751
+VIG+GT LDS R R +LS+ GIA S Y +GEHGDS + WS V+I G + D+
Sbjct: 147 KVIGTGTALDSTRLRRILSEETGIAQQSIQAYSMGEHGDSQMVPWSHVSIGGKPILDM 204
>UniRef50_A0RPE9 Cluster: Malate dehydrogenase; n=1; Campylobacter
fetus subsp. fetus 82-40|Rep: Malate dehydrogenase -
Campylobacter fetus subsp. fetus (strain 82-40)
Length = 306
Score = 108 bits (260), Expect = 2e-22
Identities = 52/165 (31%), Positives = 91/165 (55%)
Frame = +2
Query: 353 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 532
+Y + I V+TAG +++G+SR DL N ++ + K++P +I+++ +NP+D
Sbjct: 63 NYELLKDFDIVVITAGFARKDGQSRDDLAMMNAKIVSHSSKMVSKFAPKSIIIVVTNPLD 122
Query: 533 ILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVW 712
I+ YV +K SG +H+VIG LDSARFRY +S +LG+ C G +G H +S + +
Sbjct: 123 IMVYVAFKESGFARHKVIGMAGELDSARFRYYMSQKLGLNVAQCFGKCVGMHNNSMICLE 182
Query: 713 SAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKG 847
S++ N I D+ + ++++ N ++KL G
Sbjct: 183 SSIKFK-------NQSICKDEFKKYFEDIKLNTKNGGSNIVKLMG 220
>UniRef50_A7U552 Cluster: Mitochondrial malate-dehydrogenase; n=2;
Toxoplasma gondii|Rep: Mitochondrial
malate-dehydrogenase - Toxoplasma gondii
Length = 470
Score = 108 bits (260), Expect = 2e-22
Identities = 48/141 (34%), Positives = 83/141 (58%)
Frame = +2
Query: 329 NAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTIL 508
+ + + S DYS+ + + +VTAGV ++ G SR DL+ N ++ Q+ + +Y P+ +
Sbjct: 211 DVRFEGSNDYSVLKDADVIIVTAGVPRKPGMSRDDLLAINAKIMGQVGEAIKQYCPNAFV 270
Query: 509 VIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEH 688
+ +NP+D++ Y+ + GLP H+V G LDSAR R LS+RL ++ H ++G H
Sbjct: 271 ICITNPLDVMVYILREKCGLPPHKVCGMAGVLDSARLRTFLSERLNVSVDDIHALVMGGH 330
Query: 689 GDSSVPVWSAVNIAGVRLSDL 751
GD+ VP+ + G+ L +L
Sbjct: 331 GDTMVPLPRFTTVGGIPLPEL 351
>UniRef50_A2UB98 Cluster: Lactate/malate dehydrogenase precursor;
n=2; Bacteria|Rep: Lactate/malate dehydrogenase
precursor - Bacillus coagulans 36D1
Length = 327
Score = 108 bits (259), Expect = 2e-22
Identities = 55/178 (30%), Positives = 102/178 (57%), Gaps = 5/178 (2%)
Frame = +2
Query: 353 DYSITAGSKICVVTAGV-----RQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIA 517
DYS A + + + AG + E R L + N V+++++ + KY+ + +++
Sbjct: 66 DYSECADADVIICAAGPSVLPSEKDEMPDRAGLARTNAAVVREVMAGITKYTKEAVIIFI 125
Query: 518 SNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDS 697
+NP+D + Y+ G K R+ G+GT LDSAR R L+++ I S GY++GEHG +
Sbjct: 126 TNPLDTIVYIAENEFGYSKGRIFGTGTMLDSARLRQLVAENYSIDPKSVTGYMMGEHGFT 185
Query: 698 SVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXGXSD 871
+ PV+S +N+ G R +L++ + +P + + + VVK+A+ V+ KG+T+ G ++
Sbjct: 186 AFPVFSRLNVQGFREKELDS-VFKGKEPLDREAFRQKVVKTAFDVLNGKGWTNAGVAE 242
>UniRef50_A1C5Q5 Cluster: L-lactate dehydrogenase; n=4;
Pezizomycotina|Rep: L-lactate dehydrogenase -
Aspergillus clavatus
Length = 312
Score = 107 bits (258), Expect = 3e-22
Identities = 53/137 (38%), Positives = 83/137 (60%)
Frame = +2
Query: 335 KIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVI 514
+I++ T Y I V+TAG + GE+ + + RN ++++IIP + + PDTIL++
Sbjct: 65 RIRAGT-YEEAGQCDIVVITAGSKYSVGETSVQHMYRNMGIVQKIIPAMRPFRPDTILLV 123
Query: 515 ASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGD 694
SNPVD+LT V ++SGLP +V+GSGT L+S R R L++ G+A S Y++G HG
Sbjct: 124 VSNPVDLLTTVAQQLSGLPPTQVLGSGTLLESVRLRGLVAKTTGVAPDSVDLYVLGVHGI 183
Query: 695 SSVPVWSAVNIAGVRLS 745
WS + G+ L+
Sbjct: 184 GETVAWSTATVGGLSLA 200
>UniRef50_Q7NHJ3 Cluster: Malate dehydrogenase; n=13; cellular
organisms|Rep: Malate dehydrogenase - Gloeobacter
violaceus
Length = 325
Score = 107 bits (257), Expect = 4e-22
Identities = 52/150 (34%), Positives = 87/150 (58%)
Frame = +2
Query: 302 CSTDQHS*GNAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQL 481
C + H+ +I + DY+ TAGS + VV AG ++ G SR DL+ NT ++ ++ +
Sbjct: 56 CGVEGHT---CRITGTNDYAQTAGSDVLVVAAGFARQPGMSRDDLLLTNTRIVFEVTQKA 112
Query: 482 IKYSPDTILVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTS 661
+ +SP+ +V+ +NP+D +++V W+ SGL RV+G LD+ARF ++ LG +
Sbjct: 113 VAHSPEATVVVVTNPLDAMSHVAWRASGLVPERVMGMAGVLDAARFETFIAWELGFSVRD 172
Query: 662 CHGYIIGEHGDSSVPVWSAVNIAGVRLSDL 751
++G HGD VP+ I+GV L+ L
Sbjct: 173 IRAMVLGGHGDLMVPLPRYTTISGVPLTQL 202
>UniRef50_A0LRV1 Cluster: Lactate/malate dehydrogenase; n=3;
Actinomycetales|Rep: Lactate/malate dehydrogenase -
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Length = 330
Score = 106 bits (255), Expect = 7e-22
Identities = 51/146 (34%), Positives = 87/146 (59%), Gaps = 4/146 (2%)
Frame = +2
Query: 326 GNAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTI 505
G Y + A + I ++TAGV ++ G SR+DL++ N +++ + + KY+P +
Sbjct: 72 GKTTSPDGAGYEVIADASIVIITAGVPRKPGMSRMDLLETNARIVRGVAENIAKYAPSAV 131
Query: 506 LVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGE 685
+++ SNP+D +T +T ++G PK+RV+G LD+ARF + +++ LG+ + +G
Sbjct: 132 VIVVSNPLDEMTALTQLVTGFPKNRVMGQAGMLDTARFSHFVAEELGVPIRAVRTLTLGS 191
Query: 686 HGDSSVPVWSA--VNIAGV--RLSDL 751
HGD+ VPV S V I G RL+DL
Sbjct: 192 HGDTMVPVPSQCFVTIDGEQRRLADL 217
>UniRef50_Q5LXE1 Cluster: Malate dehydrogenase; n=115; cellular
organisms|Rep: Malate dehydrogenase - Silicibacter
pomeroyi
Length = 320
Score = 105 bits (253), Expect = 1e-21
Identities = 49/141 (34%), Positives = 84/141 (59%)
Frame = +2
Query: 329 NAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTIL 508
+AK++ + Y+ AG+ +C+VTAGV ++ G SR DL+ N V+K + + +PD +
Sbjct: 57 DAKLKGTQSYADIAGADVCIVTAGVPRKPGMSRDDLLGINLKVMKSVGEGIRDNAPDAFV 116
Query: 509 VIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEH 688
+ +NP+D + + + SGLP ++V G LDSARFR+ L++ ++ +++G H
Sbjct: 117 ICITNPLDAMVWALQQFSGLPANKVCGMAGVLDSARFRHFLAEEFNVSMKDVTAFVLGGH 176
Query: 689 GDSSVPVWSAVNIAGVRLSDL 751
GD+ VP +AG+ L DL
Sbjct: 177 GDTMVPSVRYSTVAGIPLPDL 197
>UniRef50_P0C0J4 Cluster: L-lactate dehydrogenase; n=5; Mycoplasma
hyopneumoniae|Rep: L-lactate dehydrogenase - Mycoplasma
hyopneumoniae
Length = 315
Score = 105 bits (252), Expect = 2e-21
Identities = 61/173 (35%), Positives = 92/173 (53%)
Frame = +2
Query: 344 SSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASN 523
S +Y + V+TAG Q+ GE+RL+LV N ++++I ++ + I +I +N
Sbjct: 62 SRYEYKDLKDADFIVITAGRPQKPGETRLELVADNIRIIREIALKVKESGFSGISIIVAN 121
Query: 524 PVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSV 703
PVDI+T SG +VIGSGT LD+AR ++ ++ R ++ S Y++GEHGDSS
Sbjct: 122 PVDIITRAYRDASGFSDQKVIGSGTVLDTARLQFAIAKRAKVSPNSVQAYVMGEHGDSSF 181
Query: 704 PVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
+S + IAG + G D KEL V + AY +I K T G
Sbjct: 182 VAYSNIKIAGECFCAYSKLTGIDSSNYE-KELEYPVSRRAYEIINRKRATFYG 233
>UniRef50_Q3U1V6 Cluster: Ubiquitin-conjugating enzyme E2 variant 3;
n=23; Tetrapoda|Rep: Ubiquitin-conjugating enzyme E2
variant 3 - Mus musculus (Mouse)
Length = 471
Score = 105 bits (251), Expect = 2e-21
Identities = 50/126 (39%), Positives = 78/126 (61%)
Frame = +2
Query: 338 IQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIA 517
++ S D S +A SK+ + TA ES L VQ N D+ + ++P L YS +L++A
Sbjct: 234 VEISKDLSASAHSKVVIFTAN-SLGGSESYLHAVQSNVDMFRALVPALGHYSQHAVLLVA 292
Query: 518 SNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDS 697
S PV+I++YVTWK+S P RV+G G NLDS R +Y+++ L + T+ +++GE G++
Sbjct: 293 SQPVEIMSYVTWKLSTFPATRVVGIGCNLDSQRLQYIITSVLKVQTSGKEVWVVGEQGEN 352
Query: 698 SVPVWS 715
V WS
Sbjct: 353 KVCSWS 358
>UniRef50_A6Q7S2 Cluster: Malate dehydrogenase, NAD-dependent; n=1;
Sulfurovum sp. NBC37-1|Rep: Malate dehydrogenase,
NAD-dependent - Sulfurovum sp. (strain NBC37-1)
Length = 320
Score = 104 bits (249), Expect = 3e-21
Identities = 46/127 (36%), Positives = 78/127 (61%)
Frame = +2
Query: 371 GSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYVT 550
GS + ++TAG + G SR DL+ +N D++K ++ +Y+PD I+++ SNP+D++TYV
Sbjct: 73 GSDVVIITAGAPRTPGMSRDDLLFKNADIVKCYSREIKEYAPDAIVIVVSNPLDVMTYVA 132
Query: 551 WKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSAVNIA 730
K +G P+ RV+G LD+AR + + ++L ++G HGD+ VP+ +A
Sbjct: 133 LKETGFPRQRVLGMAGILDAARMAHFIYEKLEYGAGQIRATVMGGHGDTMVPLPKFTTVA 192
Query: 731 GVRLSDL 751
GV + DL
Sbjct: 193 GVPIEDL 199
>UniRef50_O26290 Cluster: Malate dehydrogenase; n=2;
Methanobacteriaceae|Rep: Malate dehydrogenase -
Methanobacterium thermoautotrophicum
Length = 325
Score = 104 bits (249), Expect = 3e-21
Identities = 53/179 (29%), Positives = 95/179 (53%), Gaps = 1/179 (0%)
Frame = +2
Query: 329 NAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTIL 508
+ K+++S D GS+I V+TAGV + R DL +N ++ Q+ +++PD+I+
Sbjct: 58 SVKLENSADIENVYGSRIVVITAGVPRTADMDRDDLAFKNGRIVADYARQIARFAPDSII 117
Query: 509 VIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEH 688
++ +NPVD++TYV + SG RV G G +LDS R + ++ + + H +IG+H
Sbjct: 118 LVVTNPVDVMTYVALRYSGFHPSRVFGLGNHLDSLRLKNYMARHFNVHVSEVHTRVIGQH 177
Query: 689 GDSSVPVWSAVNIAGVRLSD-LNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
G VP+ S+ +I G+ + + + K+ + V+ + +I KG T G
Sbjct: 178 GPYMVPLISSTSIGGIPIEHYARRDYFSGYKKFDLKKTIDKVIHAGSNIISRKGATEYG 236
>UniRef50_Q4UJ29 Cluster: L-lactate dehydrogenase, putative; n=2;
Theileria|Rep: L-lactate dehydrogenase, putative -
Theileria annulata
Length = 367
Score = 103 bits (248), Expect = 5e-21
Identities = 51/166 (30%), Positives = 92/166 (55%)
Frame = +2
Query: 350 TDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 529
T T G + A + E +R DLV N+ +++ + + KY+P+ +++ +NP+
Sbjct: 118 TAMECTMGKGARLAKAPTKSNEEWNRDDLVGYNSKIIRDVGENIKKYAPEAFVIVITNPM 177
Query: 530 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPV 709
D++ ++ K++G PK+ V+G G LDS+R ++++LG+ HG +IG HGDS +P+
Sbjct: 178 DVMVHLMLKVTGFPKNMVVGMGGLLDSSRMNCYIAEKLGVNPKYVHGSVIGAHGDSMIPL 237
Query: 710 WSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKG 847
S + G+ + Q E+ KE+ E V SA+ ++KL G
Sbjct: 238 VSRSTVYGIPILQFVEQ--GYITMEDIKEIEERTVTSAFEILKLYG 281
>UniRef50_A5Z9B1 Cluster: Putative uncharacterized protein; n=1;
Eubacterium ventriosum ATCC 27560|Rep: Putative
uncharacterized protein - Eubacterium ventriosum ATCC
27560
Length = 312
Score = 103 bits (246), Expect = 8e-21
Identities = 60/175 (34%), Positives = 97/175 (55%), Gaps = 5/175 (2%)
Frame = +2
Query: 353 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 532
DYS + I V++AGV + G++RLD++ + + ++ I+ L K I++ +NP D
Sbjct: 66 DYSDCKDADIIVISAGVPRLPGQTRLDVLDGSVECVRDIVSNLNKIEIKGIIITITNPAD 125
Query: 533 ILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVW 712
I+ K +GLPK+RV +GT+LD+AR R ++D IA S G+ +GEHGDSS+ +
Sbjct: 126 IIADFVRKATGLPKNRVFSTGTSLDTARMRRTVADLCNIAPQSVIGFAMGEHGDSSMVPF 185
Query: 713 SAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKS-----AYXVIKLKGYTSXG 862
S + I G L +++PE + +L E V+ +I+ KG T G
Sbjct: 186 SNLTIFGKNYKHLK-----EENPERFGKLSEKVITDQTHMRGMDIIEGKGSTEFG 235
>UniRef50_Q3J7E7 Cluster: Malate dehydrogenase; n=5;
Gammaproteobacteria|Rep: Malate dehydrogenase -
Nitrosococcus oceani (strain ATCC 19707 / NCIMB 11848)
Length = 311
Score = 103 bits (246), Expect = 8e-21
Identities = 45/144 (31%), Positives = 85/144 (59%)
Frame = +2
Query: 329 NAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTIL 508
+A++ ST+Y + A S + V+TAG ++ G SR D++ N ++ I+ +++++P +++
Sbjct: 58 DARVTGSTNYELIADSDLVVITAGKPRKPGMSRSDVLDSNLPIITDIMNNVMRFAPQSLV 117
Query: 509 VIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEH 688
+I +NPVD+LTY W+ G + RV G LDSAR ++ G++ ++G H
Sbjct: 118 MIVTNPVDVLTYHAWRHCGWDRARVFGQAGVLDSARMASFIAGETGLSVKDISAMVLGGH 177
Query: 689 GDSSVPVWSAVNIAGVRLSDLNNQ 760
GD+ +P+ I+G+ L+ +Q
Sbjct: 178 GDTMLPLIRYTTISGIPLTHFLDQ 201
>UniRef50_Q8RED8 Cluster: L-lactate dehydrogenase; n=3;
Fusobacterium nucleatum|Rep: L-lactate dehydrogenase -
Fusobacterium nucleatum subsp. nucleatum
Length = 318
Score = 103 bits (246), Expect = 8e-21
Identities = 58/171 (33%), Positives = 92/171 (53%), Gaps = 1/171 (0%)
Frame = +2
Query: 353 DYSITAGSKICVVTAGVRQ-REGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPV 529
D I SK+ V+ V + E RL+ ++ + + +K +P ++K + I V +NPV
Sbjct: 64 DGGIQELSKMDVIVISVGSLTKNEQRLEELKGSLEAIKSFVPDVVKAGFNGIFVTITNPV 123
Query: 530 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPV 709
DI+TY ++SG PK+RVIG+GT LDSAR + +LS+ I + Y++GEHGD+ +
Sbjct: 124 DIVTYFVRELSGFPKNRVIGTGTGLDSARLKRILSEVTNIDSQVIQAYMLGEHGDTQIAN 183
Query: 710 WSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
+S+ I GV D L + VV++A+ +I K T G
Sbjct: 184 FSSATIQGVPFLDYMKTHPEQFKGVELSVLEKQVVRTAWDIISGKNCTEFG 234
>UniRef50_A7DSJ4 Cluster: Lactate/malate dehydrogenase; n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep:
Lactate/malate dehydrogenase - Candidatus Nitrosopumilus
maritimus SCM1
Length = 303
Score = 101 bits (243), Expect = 2e-20
Identities = 54/170 (31%), Positives = 95/170 (55%), Gaps = 3/170 (1%)
Frame = +2
Query: 338 IQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIA 517
I+ + DYS GS I ++ A V + R + + ++K I ++ KY P I+++
Sbjct: 58 IRGTDDYSELIGSDIVIIAASVGIYT-KHRAENIDHQVAMIKNIAKKIKKYCPSAIVLLV 116
Query: 518 SNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTS-CHGYIIGEHGD 694
SNP+D+LTY K +G + +VIG ++LD++RFRY +S+ L + +S + ++GEHGD
Sbjct: 117 SNPLDVLTYFFQKTTGFSRFKVIGIASSLDTSRFRYYISETLSVPQSSVSNALVLGEHGD 176
Query: 695 SSVPVWSAVNIAGVRLSDL--NNQIGTDDDPENWKELHENVVKSAYXVIK 838
S VP++S V++ L + + TD+ W+ L +S + + K
Sbjct: 177 SMVPIFSGVSVGDNPLFSMIDSRDTITDNVRNYWRTLRNFKSRSQFGIAK 226
>UniRef50_UPI000023CE12 Cluster: hypothetical protein FG10444.1;
n=1; Gibberella zeae PH-1|Rep: hypothetical protein
FG10444.1 - Gibberella zeae PH-1
Length = 309
Score = 101 bits (241), Expect = 3e-20
Identities = 45/141 (31%), Positives = 87/141 (61%)
Frame = +2
Query: 329 NAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTIL 508
+ +++S+T Y A + V+TA + G++ +D RNT +L+ ++ + + DT+L
Sbjct: 59 STRVRSAT-YHEAAQCDLVVITAASKHMLGQTTIDYTSRNTSMLRGVMEAMKPFRADTVL 117
Query: 509 VIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEH 688
+I ++PVD+LT + ++SGLP+ +V G+GT LD+ R R +++ R ++ + +++G H
Sbjct: 118 LIVADPVDLLTSLAKQMSGLPESQVFGTGTALDTYRLRGMIASRALVSPYTVDAFVVGRH 177
Query: 689 GDSSVPVWSAVNIAGVRLSDL 751
G+ V VWS+ I V + D+
Sbjct: 178 GEEQVVVWSSATIGAVPIQDV 198
>UniRef50_Q5CYZ2 Cluster: Lactate dehydrogenase, adjacent gene
encodes predicted malate dehydrogenase; n=8;
Cryptosporidium|Rep: Lactate dehydrogenase, adjacent
gene encodes predicted malate dehydrogenase -
Cryptosporidium parvum Iowa II
Length = 337
Score = 101 bits (241), Expect = 3e-20
Identities = 47/143 (32%), Positives = 81/143 (56%)
Frame = +2
Query: 332 AKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILV 511
+K+ + DY+ +GS + ++TA + R + R +L+ N +L + + KY P+ ++
Sbjct: 75 SKVIGTNDYADISGSDVVIITASIPGRPKDDRSELLFGNARILDSVAEGVKKYCPNAFVI 134
Query: 512 IASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHG 691
+NP+D++ K+SGLP ++V G LDS+RFR ++ G+ + +IG HG
Sbjct: 135 CITNPLDVMVSHFQKVSGLPHNKVCGMAGVLDSSRFRTFIAQHFGVNASDVSANVIGGHG 194
Query: 692 DSSVPVWSAVNIAGVRLSDLNNQ 760
D VPV S+V++ GV LS Q
Sbjct: 195 DGMVPVTSSVSVGGVPLSSFIKQ 217
>UniRef50_Q4A0K7 Cluster: Lactate dehydrogenase; n=1; Staphylococcus
saprophyticus subsp. saprophyticus ATCC 15305|Rep:
Lactate dehydrogenase - Staphylococcus saprophyticus
subsp. saprophyticus (strain ATCC 15305 /DSM 20229)
Length = 310
Score = 100 bits (239), Expect = 6e-20
Identities = 53/179 (29%), Positives = 95/179 (53%), Gaps = 1/179 (0%)
Frame = +2
Query: 335 KIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVI 514
KI+S +T I + + + R L Q N D++K I+ Q+ + + + ++++
Sbjct: 59 KIRSGVYQDLTDADFIVIAASEATDKNNGDRTLLAQGNHDIIKGIMSQIAEVTQEAVVIL 118
Query: 515 ASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGD 694
SNPVD + Y +I P H++IG+GT L+++RF+ +++D I + ++IGEHG
Sbjct: 119 ISNPVDSMVYFANQID-YPAHKIIGTGTALETSRFKTIIADHYQIDPNNVEAFVIGEHGQ 177
Query: 695 SSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKS-AYXVIKLKGYTSXGXS 868
++PVWS V+I G+ LS+ D P K +++ + V KG+T+ S
Sbjct: 178 HAIPVWSKVHIHGMELSEFE---ALSDRPAIDKSHISSIINEVSMDVFYQKGWTNAAIS 233
>UniRef50_Q7UY63 Cluster: L-lactate/malate dehydrogenase; n=2;
Planctomycetaceae|Rep: L-lactate/malate dehydrogenase -
Rhodopirellula baltica
Length = 304
Score = 99.5 bits (237), Expect = 1e-19
Identities = 64/179 (35%), Positives = 92/179 (51%), Gaps = 1/179 (0%)
Frame = +2
Query: 329 NAKIQSSTDYSITAGSKICVVTAGVRQR-EGESRLDLVQRNTDVLKQIIPQLIKYSPDTI 505
N KI SS + + + S + + TA V R ++RL++ N +L+ +P L K SP+ I
Sbjct: 55 NIKI-SSGEIADSKDSDVIIFTASVPFRYPNQTRLEMGIDNMPILRDWMPGLAKASPNAI 113
Query: 506 LVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGE 685
+V+ SNPVD L Y T +++G RVIG+GT +DS R+R LLS L I YI+GE
Sbjct: 114 VVMVSNPVDALAYETIRLTGFDPKRVIGTGTLVDSIRYRALLSTELKIHAQDIRAYILGE 173
Query: 686 HGDSSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
HGD+ S G R + + + E Y V +LKG+TS G
Sbjct: 174 HGDTQFAASSIAMTGGERFYPSDTS----------RRMFEETKAMGYEVFRLKGHTSYG 222
>UniRef50_Q6LZI3 Cluster: Malate dehydrogenase; n=5;
Methanococcus|Rep: Malate dehydrogenase - Methanococcus
maripaludis
Length = 314
Score = 99.5 bits (237), Expect = 1e-19
Identities = 57/170 (33%), Positives = 92/170 (54%)
Frame = +2
Query: 353 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 532
D S TA S I ++TAG+ + SR+DL++ N ++K + + + DT + + SNPVD
Sbjct: 68 DLSCTANSDITIITAGMARTGEMSRIDLMKGNAKIVKNYVKNIANFG-DTKIFMISNPVD 126
Query: 533 ILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVW 712
++TY SG K++V G GT+LDS RF+ ++ + I+GEHGDS VPV
Sbjct: 127 LMTYKALIESGYEKNQVFGLGTHLDSMRFKVAVAKHFEVHLDDVRTRIVGEHGDSMVPVI 186
Query: 713 SAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
SA + G+ + L +D P ++++ E + +I LK + G
Sbjct: 187 SATAVGGIPIKRLPKY---EDFP--YEKILERIKGYGQEIINLKNGSEYG 231
>UniRef50_Q27743 Cluster: L-lactate dehydrogenase; n=17;
Apicomplexa|Rep: L-lactate dehydrogenase - Plasmodium
falciparum (isolate CDC / Honduras)
Length = 316
Score = 99.1 bits (236), Expect = 1e-19
Identities = 52/187 (27%), Positives = 103/187 (55%), Gaps = 6/187 (3%)
Frame = +2
Query: 299 TCSTDQHS*GNAKIQSSTDYSITAGSKICVVTAGVRQREGES-----RLDLVQRNTDVLK 463
T T+ + N K+ S Y AG+ + +VTAG + G+S R DL+ N ++
Sbjct: 48 TSHTNVMAYSNCKVSGSNTYDDLAGADVVIVTAGFTKAPGKSDKEWNRDDLLPLNNKIMI 107
Query: 464 QIIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRL 643
+I + K P+ +++ +NPVD++ + + SG+PK+++IG G LD++R +Y +S +L
Sbjct: 108 EIGGHIKKNCPNAFIIVVTNPVDVMVQLLHQHSGVPKNKIIGLGGVLDTSRLKYYISQKL 167
Query: 644 GIATTSCHGYIIGEHGDSSVPVWSAVNIAGVRLSD-LNNQIGTDDDPENWKELHENVVKS 820
+ + +I+G HG+ V + + + G+ L + +NN++ +D + E + + V +
Sbjct: 168 NVCPRDVNAHIVGAHGNKMVLLKRYITVGGIPLQEFINNKLISDAELE---AIFDRTVNT 224
Query: 821 AYXVIKL 841
A ++ L
Sbjct: 225 ALEIVNL 231
>UniRef50_Q8I8U4 Cluster: Lactate dehydrogenase; n=3;
Eimeriorina|Rep: Lactate dehydrogenase - Eimeria tenella
Length = 331
Score = 98.3 bits (234), Expect = 2e-19
Identities = 49/158 (31%), Positives = 86/158 (54%), Gaps = 5/158 (3%)
Frame = +2
Query: 302 CSTDQHS*GNAKIQSSTDYSITAGSKICVVTAGVRQREGES-----RLDLVQRNTDVLKQ 466
C T + ++Q + Y+ G+ + ++TAG+ + G+S R DL+ N +L++
Sbjct: 54 CHTAAVADNGVRVQGANSYASLEGADVVIITAGITKAAGKSDQEWSRKDLLPVNVKILRE 113
Query: 467 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLG 646
+ + ++ P ++ +NP+D++ + +GLP RV G LDSARFR LL+DRLG
Sbjct: 114 VGAAIKQFCPHAFVINITNPLDVMVAALREAAGLPAARVCGMAGVLDSARFRRLLADRLG 173
Query: 647 IATTSCHGYIIGEHGDSSVPVWSAVNIAGVRLSDLNNQ 760
++ ++G HGD+ VP+ + GV L +L Q
Sbjct: 174 VSPRDVQAMVLGVHGDNMVPLSRFATVNGVPLGELARQ 211
>UniRef50_Q6A6E3 Cluster: L-lactate dehydrogenase; n=1;
Propionibacterium acnes|Rep: L-lactate dehydrogenase -
Propionibacterium acnes
Length = 321
Score = 97.5 bits (232), Expect = 4e-19
Identities = 56/176 (31%), Positives = 90/176 (51%), Gaps = 6/176 (3%)
Frame = +2
Query: 353 DYSITAGSKICVVTAGVR------QREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVI 514
DY + + + ++TAG G +R +L N +++ + Q+ + D ++I
Sbjct: 68 DYDDLSNADVIIMTAGPSIDASNGPATGAARRELAATNGKIIRSTMTQITSRNHDAAIII 127
Query: 515 ASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGD 694
SNP+D L ++ P+ V+G+GT LDSAR +++D LG+ GY+IGEHG
Sbjct: 128 CSNPLDALVHIASTEFDHPQGLVLGTGTILDSARMCRVVADHLGVDPDYVRGYMIGEHGP 187
Query: 695 SSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
S P+++ VN+ GV L D DP + EL + + V LKG+TS G
Sbjct: 188 SGFPMFTGVNVGGVGFDGLAKLF--DADPMDRDELTTRINDAGTAVFNLKGWTSAG 241
>UniRef50_Q6JH30 Cluster: Lactate dehydrogenase; n=3; Plasmodium
(Plasmodium)|Rep: Lactate dehydrogenase - Plasmodium
vivax
Length = 299
Score = 96.7 bits (230), Expect = 7e-19
Identities = 49/177 (27%), Positives = 97/177 (54%), Gaps = 6/177 (3%)
Frame = +2
Query: 329 NAKIQSSTDYSITAGSKICVVTAGVRQREGES-----RLDLVQRNTDVLKQIIPQLIKYS 493
N K+ S Y G+ + +VTAG + G+S R DL+ N ++ +I +
Sbjct: 51 NCKVTGSNSYDDLKGADVVIVTAGFTKAPGKSDKEWNRDDLLPLNNKIMIEIGGHIKNLC 110
Query: 494 PDTILVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGY 673
P+ +++ +NPVD++ + ++ SG+PK+++IG G LD++R +Y +S +L + +
Sbjct: 111 PNAFIIVVTNPVDVMVQLLFEHSGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVNAL 170
Query: 674 IIGEHGDSSVPVWSAVNIAGVRLSD-LNNQIGTDDDPENWKELHENVVKSAYXVIKL 841
I+G HG+ V + + + G+ L + +NN+ TD++ E + + V +A ++ L
Sbjct: 171 IVGAHGNKMVLLKRYITVGGIPLQEFINNKKITDEEVEG---IFDRTVNTALEIVNL 224
>UniRef50_Q92AZ3 Cluster: Lin1775 protein; n=13; Listeria|Rep:
Lin1775 protein - Listeria innocua
Length = 302
Score = 95.9 bits (228), Expect = 1e-18
Identities = 52/173 (30%), Positives = 90/173 (52%)
Frame = +2
Query: 344 SSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASN 523
++ + + + I V+ G E R++ + + + +I+P+++ I V +N
Sbjct: 61 TANSWEALSDADIIVMAVGPETLLREDRMEELVETSRSVTEIVPKILATGFKGIFVNITN 120
Query: 524 PVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSV 703
P D++T + KISG RV G+GT+LD+AR R ++ + L I S GY++GEHG+S
Sbjct: 121 PCDVITMLIQKISGFDHSRVFGTGTSLDTARMRRVVGEALHINPKSIEGYVLGEHGESQF 180
Query: 704 PVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
WS V I GV ++D + P + L + V + ++ KG+TS G
Sbjct: 181 VAWSTVKIGGVNITDYKTK-----TPLDLPALKDAVRGGGWNILTGKGWTSFG 228
>UniRef50_Q6ABQ3 Cluster: L-lactate dehydrogenase; n=1;
Propionibacterium acnes|Rep: L-lactate dehydrogenase -
Propionibacterium acnes
Length = 322
Score = 95.1 bits (226), Expect = 2e-18
Identities = 46/150 (30%), Positives = 90/150 (60%)
Frame = +2
Query: 419 ESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVIGSGT 598
+SR L Q N+ V+++++ + +Y+ +++ +NP+D+ ++ P + V+G+GT
Sbjct: 95 DSRNSLAQVNSKVIREVMGNICQYTHSAPIILITNPLDVNVHIAATEFDYPTNLVVGTGT 154
Query: 599 NLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSAVNIAGVRLSDLNNQIGTDDD 778
LDSAR R L+D G++ S +++GEHG ++ P S +I G+ L++ +G
Sbjct: 155 ALDSARLRRHLADWAGVSPDSVQAFMLGEHGATAFPYLSHASIGGLTLAEATTALGL--Q 212
Query: 779 PENWKELHENVVKSAYXVIKLKGYTSXGXS 868
P + ++ +VV+SA+ +++ KG+TS G S
Sbjct: 213 PLSPDQVGNSVVQSAFDILEGKGWTSSGIS 242
>UniRef50_P59050 Cluster: L-lactate dehydrogenase 1; n=3;
Bifidobacterium longum|Rep: L-lactate dehydrogenase 1 -
Bifidobacterium longum
Length = 316
Score = 95.1 bits (226), Expect = 2e-18
Identities = 39/127 (30%), Positives = 76/127 (59%)
Frame = +2
Query: 353 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 532
DY+ + I V+T G + +R+ + ++ +++ ++ D ++V+ SNPVD
Sbjct: 68 DYADCKDADIVVITVGRKPPANSNRMAELGFTVGLVGEVVDNVMASGFDGVIVMVSNPVD 127
Query: 533 ILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVW 712
++ + WK SGLP+ +V+G+GT LD++R + ++ + G+ + G+++GEHGDS W
Sbjct: 128 VMAWYAWKRSGLPRTQVLGTGTALDTSRLKTIIGEETGLDPRNVGGFVMGEHGDSQFTAW 187
Query: 713 SAVNIAG 733
S V++ G
Sbjct: 188 STVSLGG 194
>UniRef50_UPI00015BB1FC Cluster: malate dehydrogenase (NAD); n=1;
Ignicoccus hospitalis KIN4/I|Rep: malate dehydrogenase
(NAD) - Ignicoccus hospitalis KIN4/I
Length = 311
Score = 94.7 bits (225), Expect = 3e-18
Identities = 53/176 (30%), Positives = 93/176 (52%)
Frame = +2
Query: 335 KIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVI 514
++++ D S + V+TAG ++ SR DL + N +++ I +L +P ++
Sbjct: 62 QVEAYDDVSKVENADAIVITAGKPRKADMSRRDLAKVNAQIIRDIGDKLRDRNPGAFYMV 121
Query: 515 ASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGD 694
+NPVD++T + + G K VIG+GT+LD+ RFR +S+ L + GY++GEHG+
Sbjct: 122 ITNPVDVMTMILSDVIG-NKGTVIGTGTSLDTYRFRSAVSELLNEPIAAIDGYVVGEHGE 180
Query: 695 SSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
+ WS V + GV + + + G D + + E V + A +I +G T G
Sbjct: 181 EAFVAWSTVTVKGVPIDEYIKEKGLD---LSRSRIEEYVKEVAATIIAKQGATIWG 233
>UniRef50_Q87JV1 Cluster: Lactate dehydrogenase; n=4; Vibrio|Rep:
Lactate dehydrogenase - Vibrio parahaemolyticus
Length = 317
Score = 94.7 bits (225), Expect = 3e-18
Identities = 55/181 (30%), Positives = 97/181 (53%), Gaps = 3/181 (1%)
Frame = +2
Query: 329 NAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTIL 508
N +I S DY G+ I V+TAG + ++G++RLD+ + N + +I ++ + +P +L
Sbjct: 56 NTRIIPSDDYLDLLGADIVVITAGAQIQQGQTRLDIAEINAKIGVEIARKIERVAPKAVL 115
Query: 509 VIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEH 688
++ SNP DI+ + +G ++VI SG +D+AR ++++R+ + + GY++GEH
Sbjct: 116 IVVSNPCDIVAHFITTNTGFEPNKVISSGCVIDTARLMSIVANRVDLDPKNIFGYVLGEH 175
Query: 689 GDSSVPVWSAVNIAGVRLS---DLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSX 859
G S ++IAG D +N D D EL E V ++ Y + + K T
Sbjct: 176 GSHCFTPKSLISIAGQPADYYCDTHNIERIDAD-----ELLEAVKQAGYEIFRRKHNTVH 230
Query: 860 G 862
G
Sbjct: 231 G 231
>UniRef50_Q04GC4 Cluster: Enzyme with possible activities of L-2-
hydroxyisocaproate/malate/lactate dehydrogenase; n=2;
Oenococcus oeni|Rep: Enzyme with possible activities of
L-2- hydroxyisocaproate/malate/lactate dehydrogenase -
Oenococcus oeni (strain BAA-331 / PSU-1)
Length = 304
Score = 93.9 bits (223), Expect = 5e-18
Identities = 58/170 (34%), Positives = 89/170 (52%), Gaps = 2/170 (1%)
Frame = +2
Query: 353 DYSITAGSKICVVTAGVRQREGES--RLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 526
DY A + + V T G ES R +Q N ++ + QL K D + + +NP
Sbjct: 63 DYKDLADANLIVSTFGNVNLTVESGDRFAELQFNVKQIRSMAEQLKKVHFDGVFLTITNP 122
Query: 527 VDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVP 706
VD++T V + LPK++VIG+GT LDS+R + + +R I S G++IGEHG+S P
Sbjct: 123 VDVITAVYQRELALPKNQVIGTGTFLDSSRLKKEIGERFKIDPRSVSGFVIGEHGNSQFP 182
Query: 707 VWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTS 856
WS++ I +S ++ N +L E + A+ VI KGYT+
Sbjct: 183 AWSSIRIFDNPISSF-----AKENSVNIDDLEEKTKEDAFRVIDGKGYTN 227
>UniRef50_A7I2F1 Cluster: Malate dehydrogenase; n=1; Campylobacter
hominis ATCC BAA-381|Rep: Malate dehydrogenase -
Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 /
NCTC 13146 /CH001A)
Length = 297
Score = 93.9 bits (223), Expect = 5e-18
Identities = 52/174 (29%), Positives = 87/174 (50%)
Frame = +2
Query: 335 KIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVI 514
+I S+D ++ S I V+TAG ++ G+SR DL+ N ++ + KY+P+ I+++
Sbjct: 58 EISGSSDETLLKNSDIVVITAGKTRQAGQSRADLLNDNAKIISSCAKNVAKYAPEAIIIL 117
Query: 515 ASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGD 694
+NPVD L +V +K SG K ++I LDSAR RY ++ + T ++G H D
Sbjct: 118 ITNPVDTLAFVAYKASGFKKEKIIAMAGELDSARLRYEIAKSENVNVTDIKASVVGAHND 177
Query: 695 SSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTS 856
+ I L D + G P+N + EN + S + L+ +S
Sbjct: 178 E-------MQI----LEDEIYKFGKKFKPQNLSLIKENTINSGSKITALQKTSS 220
>UniRef50_A7GYI6 Cluster: Lactate/malate dehydrogenase, NAD binding
domain protein; n=2; Campylobacter|Rep: Lactate/malate
dehydrogenase, NAD binding domain protein -
Campylobacter curvus 525.92
Length = 297
Score = 92.7 bits (220), Expect = 1e-17
Identities = 41/117 (35%), Positives = 70/117 (59%)
Frame = +2
Query: 353 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 532
D+++ S I VVTAG ++EG++R DL+ +N V+KQ + K++P+ I++I +NP+D
Sbjct: 63 DFALIEASDIVVVTAGSPRKEGQTREDLLLKNAQVVKQTAQNIAKFAPNAIVIIVTNPLD 122
Query: 533 ILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSV 703
++ + + SG + RVIG LDSAR RY ++ I+ ++G H D +
Sbjct: 123 VMVWTVLRYSGFDRSRVIGMAGELDSARCRYEIASLKDISAKDVSAKVLGAHNDKMI 179
>UniRef50_A3ZZ88 Cluster: L-lactate/malate dehydrogenase; n=1;
Blastopirellula marina DSM 3645|Rep: L-lactate/malate
dehydrogenase - Blastopirellula marina DSM 3645
Length = 308
Score = 92.7 bits (220), Expect = 1e-17
Identities = 53/167 (31%), Positives = 88/167 (52%), Gaps = 1/167 (0%)
Frame = +2
Query: 365 TAGSKICVVTAGVRQREGE-SRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILT 541
TAGS + + + + + R + N + L++ IP L SP I V+ +NPVD++T
Sbjct: 66 TAGSDVILYCDAAQSKTSDVDRYCAARGNLERLRERIPILAAASPQAICVMVTNPVDVMT 125
Query: 542 YVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSAV 721
+ ++SG P+ RV G GT LD+AR R LLS+R + + Y+IGEHG+ V +S+
Sbjct: 126 WFALQLSGFPQERVFGVGTLLDTARLRRLLSERWSVHASDVRAYVIGEHGEDQVASFSSA 185
Query: 722 NIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
++ G + +DD L +SA + + +G+T+ G
Sbjct: 186 SLGGEAMKP------SDD----LASLARQAAESAGKIYRTRGFTNYG 222
>UniRef50_Q38YI2 Cluster: Putative malate dehydrogenase; n=1;
Lactobacillus sakei subsp. sakei 23K|Rep: Putative
malate dehydrogenase - Lactobacillus sakei subsp. sakei
(strain 23K)
Length = 301
Score = 91.5 bits (217), Expect = 3e-17
Identities = 55/184 (29%), Positives = 91/184 (49%), Gaps = 2/184 (1%)
Frame = +2
Query: 326 GNAKIQSSTDYSITAGSKICVVTAGVRQ--REGESRLDLVQRNTDVLKQIIPQLIKYSPD 499
G KI ++ D S A + + +AG + R D + + Q P+L +
Sbjct: 55 GFVKI-TANDESQLATCDLVIFSAGDISILEHSDDRFDELTYTKTAVAQWAPKLKAANFK 113
Query: 500 TILVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYII 679
IL+ +NP D++T ++G PK RV+G+GT LD+AR + + L +A S GY++
Sbjct: 114 GILLNITNPCDVITQYLQALTGFPKERVLGTGTTLDTARMQVAVGHYLNVAPNSVQGYVL 173
Query: 680 GEHGDSSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSX 859
GEHG+S WS V++ G + T PE + + + A+ ++ KGYTS
Sbjct: 174 GEHGNSQFVAWSGVHVGG-------QPLATQLSPEQLAQFEVDARQGAWEILSGKGYTSY 226
Query: 860 GXSD 871
G ++
Sbjct: 227 GIAN 230
>UniRef50_Q0P989 Cluster: L-lactate dehydrogenase; n=10;
Campylobacter|Rep: L-lactate dehydrogenase -
Campylobacter jejuni
Length = 308
Score = 91.1 bits (216), Expect = 3e-17
Identities = 57/152 (37%), Positives = 81/152 (53%), Gaps = 1/152 (0%)
Frame = +2
Query: 410 REGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVIG 589
+E SRL ++ N LK I+ L + ++A+NP D +TY T +S LPK+ V G
Sbjct: 84 KELPSRLVELKNNILELKDIVLTLKNANFKGKYIVATNPNDTITYYTQVLSQLPKNHVFG 143
Query: 590 SGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSAVNIAGVRLSDLNNQ-IG 766
SGTNLDS+R + LL+ L I + +IGEHGDS S ++ G L D Q +G
Sbjct: 144 SGTNLDSSRLKKLLAKDLNINSKDIFACMIGEHGDSQFAALSNASVLGQNLLDFYKQKLG 203
Query: 767 TDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
D D + EL + V+ Y + + KG T G
Sbjct: 204 KDLDIQ---ELEKAVISEGYFIYERKGRTEFG 232
>UniRef50_Q03ZZ4 Cluster: Enzyme with possible activities of L-2-
hydroxyisocaproate/malate/lactate dehydrogenase; n=3;
Lactobacillales|Rep: Enzyme with possible activities of
L-2- hydroxyisocaproate/malate/lactate dehydrogenase -
Leuconostoc mesenteroides subsp. mesenteroides (strain
ATCC 8293 /NCDO 523)
Length = 304
Score = 90.2 bits (214), Expect = 6e-17
Identities = 43/114 (37%), Positives = 66/114 (57%)
Frame = +2
Query: 410 REGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVIG 589
+ G R ++ NT ++Q+ L + + +L++ SNPVD++T + K +GLP ++V G
Sbjct: 84 KPGGDRFTELKANTPEVQQVGSDLKQAGFNGVLIVISNPVDVITGIYQKATGLPANQVFG 143
Query: 590 SGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSAVNIAGVRLSDL 751
+GT LD+AR + L D L I GY++GEHGDS WS VN G +L
Sbjct: 144 TGTYLDTARLKRALGDTLAIDPRGISGYMLGEHGDSQFAAWSTVNALGKNADEL 197
>UniRef50_O52354 Cluster: L-lactate dehydrogenase; n=1; Mycoplasma
gallisepticum|Rep: L-lactate dehydrogenase - Mycoplasma
gallisepticum
Length = 323
Score = 90.2 bits (214), Expect = 6e-17
Identities = 44/149 (29%), Positives = 81/149 (54%)
Frame = +2
Query: 425 RLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVIGSGTNL 604
RL L+ N +L +I +L + + +I +NP D++ V K++G H++I +G L
Sbjct: 94 RLQLMTANVKILNEIALELKRVGFKGLSIIPTNPCDVMAGVYQKVTGFDPHKIISTGCQL 153
Query: 605 DSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSAVNIAGVRLSDLNNQIGTDDDPE 784
++ R R ++S+ LG+ + S G+++GEHG ++ WS + V + L + + E
Sbjct: 154 ETMRTRKMISEALGVNSDSVEGFVVGEHGSGAIVPWSVFRVGNVPMKQLIAEGKIKE--E 211
Query: 785 NWKELHENVVKSAYXVIKLKGYTSXGXSD 871
K++ VVK A+ +IK K T G ++
Sbjct: 212 YVKDIFSRVVKEAFEIIKFKKATYFGIAE 240
>UniRef50_Q1FMY2 Cluster: L-lactate dehydrogenase; n=1; Clostridium
phytofermentans ISDg|Rep: L-lactate dehydrogenase -
Clostridium phytofermentans ISDg
Length = 319
Score = 87.8 bits (208), Expect = 3e-16
Identities = 47/174 (27%), Positives = 89/174 (51%), Gaps = 2/174 (1%)
Frame = +2
Query: 347 STDYSITAGSKICVVTAGVR--QREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIAS 520
S DYS A + + V+ G + +GE+R+ + ++K++ + D ++V S
Sbjct: 64 SGDYSDAADADLMVIAVGTNPDKNKGETRMSTLTNTALIIKEVAWHIKNSGFDGMIVSIS 123
Query: 521 NPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSS 700
NP D++T+ + +++I + T LDSAR R ++D + I S +G+++GEHG+S
Sbjct: 124 NPADVITHYLQHLLQYSSNKIISTSTVLDSARLRRAIADAVEIDQKSIYGFVLGEHGESQ 183
Query: 701 VPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
+ WS V+IAG + +L + + +L + + ++ KG T G
Sbjct: 184 MVAWSTVSIAGKPILELIKEKPEKYGQIDLSKLSDEARAGGWHILTGKGSTEFG 237
>UniRef50_Q6VVP7 Cluster: Malate dehydrogenase; n=6; Plasmodium|Rep:
Malate dehydrogenase - Plasmodium falciparum
Length = 313
Score = 86.6 bits (205), Expect = 7e-16
Identities = 43/140 (30%), Positives = 76/140 (54%)
Frame = +2
Query: 329 NAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTIL 508
N I + + I V+TAGV+++EG +R DL+ N ++K + + + +
Sbjct: 55 NRNILGTNQIEDIKDADIIVITAGVQRKEGMTREDLIGVNGKIMKSVAESVKLHCSKAFV 114
Query: 509 VIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEH 688
+ SNP+DI+ V K S LP ++ G LD++R+ L++D+L ++ + I+G H
Sbjct: 115 ICVSNPLDIMVNVFHKFSNLPHEKICGMAGILDTSRYCSLIADKLKVSAEDVNAVILGGH 174
Query: 689 GDSSVPVWSAVNIAGVRLSD 748
GD VP+ ++ GV LS+
Sbjct: 175 GDLMVPLQRYTSVNGVPLSE 194
>UniRef50_Q5M0L6 Cluster: L-2-hydroxyisocaproate dehydrogenase; n=3;
Streptococcus thermophilus|Rep: L-2-hydroxyisocaproate
dehydrogenase - Streptococcus thermophilus (strain CNRZ
1066)
Length = 316
Score = 85.8 bits (203), Expect = 1e-15
Identities = 53/173 (30%), Positives = 85/173 (49%), Gaps = 3/173 (1%)
Frame = +2
Query: 353 DYSITAGSKICVVTAG---VRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASN 523
DY + + + G ++ GE R + + Q+ +L + IL++ SN
Sbjct: 64 DYEALKDADVIISALGNIQLQHNAGEDRFAEFPFTREAVYQVAQELKQLDFKGILLVISN 123
Query: 524 PVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSV 703
PVD +T + + +G PK RVIG+GT LD+AR + + + L + S GY +GEHG+S
Sbjct: 124 PVDAVTALYQEFTGWPKERVIGTGTLLDTARMKTAVGEVLEVNPKSVSGYNLGEHGNSQF 183
Query: 704 PVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
WS V + G ++ L ++ E + L +K + V KGYTS G
Sbjct: 184 TAWSQVKVKGQDITALTSE-------EERQNLFRASMKGGHKVFYGKGYTSYG 229
>UniRef50_Q5B0T8 Cluster: Putative uncharacterized protein; n=1;
Emericella nidulans|Rep: Putative uncharacterized
protein - Emericella nidulans (Aspergillus nidulans)
Length = 237
Score = 85.8 bits (203), Expect = 1e-15
Identities = 40/101 (39%), Positives = 65/101 (64%)
Frame = +2
Query: 347 STDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP 526
S Y + I V+TAG + G++ +D + RNT +++ II ++ + DT+L+I +NP
Sbjct: 67 SATYREASQCDIVVITAGSKYLYGQTSMDYLYRNTSIVRSIINEMKPFRSDTVLLIVANP 126
Query: 527 VDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGI 649
VD++T + ++S LP +V+GSGT LDS R R LL+D G+
Sbjct: 127 VDLMTSLAKELSNLPSAQVLGSGTFLDSIRLRGLLADETGV 167
>UniRef50_Q7M9A7 Cluster: Malate dehydrogenase; n=4;
Epsilonproteobacteria|Rep: Malate dehydrogenase -
Wolinella succinogenes
Length = 314
Score = 85.0 bits (201), Expect = 2e-15
Identities = 44/138 (31%), Positives = 77/138 (55%)
Frame = +2
Query: 338 IQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIA 517
++ + + S G + V AG ++ G SR DL+ N V++ ++ ++ Y +++LV+
Sbjct: 56 VRVANEPSDLRGCDVVVFCAGSPRQPGMSRDDLLLANAKVIRTVLSEVKPYIQESVLVMV 115
Query: 518 SNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDS 697
SNP+D + Y K SGL +V+G LDSAR + ++LG + ++G HGD
Sbjct: 116 SNPLDAMVYTAIKESGLSPLQVLGMAGILDSARMASFIFEKLGYGSDQIVASVMGGHGDD 175
Query: 698 SVPVWSAVNIAGVRLSDL 751
VP+ N+AGV +++L
Sbjct: 176 MVPLPRYSNVAGVPITEL 193
>UniRef50_A2QJT7 Cluster: Catalytic activity: precursor; n=1;
Aspergillus niger|Rep: Catalytic activity: precursor -
Aspergillus niger
Length = 307
Score = 84.6 bits (200), Expect = 3e-15
Identities = 43/130 (33%), Positives = 76/130 (58%), Gaps = 1/130 (0%)
Frame = +2
Query: 335 KIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVI 514
KI+++T + + + + ++TAGV GE+ L + +LK I+ ++ ++P+ I+++
Sbjct: 58 KIEAAT-HQEASQADVVIITAGVNYTPGETTLQHLYHKFSILKSILNEMRPFNPNAIILV 116
Query: 515 ASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIG-EHG 691
+NPVD LT + I+GLP+ +VIG GT +DS R + +S LG GY++G
Sbjct: 117 VANPVDTLTTLAQDIAGLPRKQVIGVGTCIDSLRLQDEVSRFLGTTMEETEGYVVGVRDS 176
Query: 692 DSSVPVWSAV 721
+S V WS +
Sbjct: 177 ESQVVGWSGL 186
>UniRef50_P14295 Cluster: L-2-hydroxyisocaproate dehydrogenase;
n=15; Lactobacillales|Rep: L-2-hydroxyisocaproate
dehydrogenase - Lactobacillus confusus
Length = 310
Score = 84.2 bits (199), Expect = 4e-15
Identities = 43/120 (35%), Positives = 65/120 (54%)
Frame = +2
Query: 503 ILVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIG 682
+LV+ SNPVD++T + ++G P H+VIG+GT LD+AR + + + + S GY +G
Sbjct: 118 VLVVISNPVDVITALFQHVTGFPAHKVIGTGTLLDTARMQRAVGEAFDLDPRSVSGYNLG 177
Query: 683 EHGDSSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
EHG+S WS V + G + L D + + E K + V+ KGYTS G
Sbjct: 178 EHGNSQFVAWSTVRVMGQPIVTL-----ADAGDIDLAAIEEEARKGGFTVLNGKGYTSYG 232
>UniRef50_P11386 Cluster: Malate dehydrogenase; n=6;
Sulfolobaceae|Rep: Malate dehydrogenase - Sulfolobus
acidocaldarius
Length = 306
Score = 82.2 bits (194), Expect = 2e-14
Identities = 50/176 (28%), Positives = 92/176 (52%)
Frame = +2
Query: 335 KIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVI 514
++ S+ + +G+ I V+TAG ++ G SR DL N ++ + +L K + + ++
Sbjct: 58 ELLSTNNIDDISGADIVVITAGKPRKPGMSRRDLFIDNAKIMIDLAKKLPKKNKGAMYIM 117
Query: 515 ASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGD 694
+NPVD++ V K SG I +G +++ R R ++ +L I GY+ GEHG+
Sbjct: 118 VANPVDMMASVFMKYSG---ENTISTGNQVETMRMRSYIAKKLNIPAYEVGGYVGGEHGE 174
Query: 695 SSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
+++ +WS V + G S+ +G N E+ + V K A +I++ G T+ G
Sbjct: 175 AAMVLWSTVTVKGKPFSE---SLGV-----NKAEVEDYVKKIAAEIIRVLGGTTWG 222
>UniRef50_Q0PQR8 Cluster: Malate dehydrogenase NAD-dependent; n=1;
Endoriftia persephone 'Hot96_1+Hot96_2'|Rep: Malate
dehydrogenase NAD-dependent - Endoriftia persephone
'Hot96_1+Hot96_2'
Length = 170
Score = 81.8 bits (193), Expect = 2e-14
Identities = 35/110 (31%), Positives = 65/110 (59%)
Frame = +2
Query: 431 DLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDS 610
DL+ N V K++ + +++PD +++ +NP+D + Y K+SGLP R+IG LD+
Sbjct: 17 DLLDINLSVTKKVATAVKQHAPDAFVILTTNPLDSIVYAFHKLSGLPAERIIGMAGALDT 76
Query: 611 ARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSAVNIAGVRLSDLNNQ 760
ARFR ++ G++ ++G HG + +PV ++ G+ L++L +Q
Sbjct: 77 ARFRTYIAMETGLSVKDVSCLVMGGHGPTMIPVTRTASVGGIPLTELLDQ 126
>UniRef50_Q6YPG1 Cluster: Putative uncharacterized protein
OJA1212_C06.24; n=1; Oryza sativa (japonica
cultivar-group)|Rep: Putative uncharacterized protein
OJA1212_C06.24 - Oryza sativa subsp. japonica (Rice)
Length = 255
Score = 81.4 bits (192), Expect = 3e-14
Identities = 47/96 (48%), Positives = 56/96 (58%)
Frame = -3
Query: 636 SDSR*RNRAESKLVPDPMTRCLGSPLIFHVTYVRISTGLLAITNIVSGLYFISCGIICLS 457
S R RN ES+LVP+PMTR G+P FH TYV STGL I++ SG S G I +
Sbjct: 47 SARRKRNLEESRLVPEPMTRLAGNPDSFHATYVSTSTGLETISSSASGECSASAGTIFRN 106
Query: 456 TSVFLCTRSRRDSPSRCRTPAVTTQIFEPAVIE*SV 349
++ F C+R RR SP R PAVT EP V SV
Sbjct: 107 SATFRCSRFRRLSPGIWRAPAVTMARSEPRVTARSV 142
>UniRef50_Q9PHY2 Cluster: Probable malate dehydrogenase; n=12;
Campylobacter|Rep: Probable malate dehydrogenase -
Campylobacter jejuni
Length = 300
Score = 80.2 bits (189), Expect = 6e-14
Identities = 44/163 (26%), Positives = 82/163 (50%)
Frame = +2
Query: 329 NAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTIL 508
N + + DY+ T S I + +AG +++G+SR +L+Q NT ++ ++ ++ D +
Sbjct: 55 NIDLLCTKDYTHTKNSDIVLFSAGFARKDGQSREELLQLNTSIMLDCAKKIKDFTEDPLF 114
Query: 509 VIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEH 688
+I +NPVD L ++ ++I LD+ARF+Y L+ +L + + +IG H
Sbjct: 115 IILTNPVDFLLNTLYESGIFSSKKIIAMAGVLDNARFKYELAKKLNVKMSRVDTRLIGFH 174
Query: 689 GDSSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVK 817
D V V S ++ +S+ N+ +D K V+K
Sbjct: 175 NDDMVLVKSYASVKNKNISEFLNEEEFEDLENEVKTGGAKVIK 217
>UniRef50_A4E9T4 Cluster: Putative uncharacterized protein; n=1;
Collinsella aerofaciens ATCC 25986|Rep: Putative
uncharacterized protein - Collinsella aerofaciens ATCC
25986
Length = 325
Score = 79.8 bits (188), Expect = 9e-14
Identities = 54/176 (30%), Positives = 82/176 (46%), Gaps = 1/176 (0%)
Frame = +2
Query: 329 NAKIQSSTD-YSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTI 505
N KI + D Y A + V AG +R + TD + +++ D I
Sbjct: 59 NTKIVNCYDHYEELACCDVIVNAAGKVALAAGNRDGELFFTTDAARSFAKRIVDAGFDGI 118
Query: 506 LVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGE 685
V SNP D++ W ++G ++IGSG LDSAR R +S ++G++ S Y+IGE
Sbjct: 119 FVSISNPCDVVCTELWHLTGYDPKKIIGSGCGLDSARLRTEISKKVGVSPKSVDAYMIGE 178
Query: 686 HGDSSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYT 853
HG S + + A IAG L++L + D + E+ E K Y + K T
Sbjct: 179 HGFSQLAAFKAATIAGKSLNELQAE-NPDKYAFDHMEVEELARKGGYVTYQGKQCT 233
>UniRef50_Q7VFV4 Cluster: Malate dehydrogenase; n=1; Helicobacter
hepaticus|Rep: Malate dehydrogenase - Helicobacter
hepaticus
Length = 315
Score = 79.4 bits (187), Expect = 1e-13
Identities = 39/124 (31%), Positives = 65/124 (52%)
Frame = +2
Query: 338 IQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIA 517
I+ Y A S++ ++TAG + +R DL+ +N ++++I + + +P ++L++
Sbjct: 61 IKGCNSYEEIAESEVVIITAGFPRTPNMTRNDLLLKNASIIQEISSNVARIAPQSLLIVV 120
Query: 518 SNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDS 697
SNP+D + V + S K RVIG LDSAR Y LG Y+IG H D
Sbjct: 121 SNPLDAMCLVAKQWSKFEKERVIGMAGILDSARLTYESKVMLGDFNKHIQSYVIGSHSDD 180
Query: 698 SVPV 709
+P+
Sbjct: 181 MLPL 184
>UniRef50_Q82R06 Cluster: Putative lactate dehydrogenase; n=1;
Streptomyces avermitilis|Rep: Putative lactate
dehydrogenase - Streptomyces avermitilis
Length = 303
Score = 77.0 bits (181), Expect = 6e-13
Identities = 44/118 (37%), Positives = 67/118 (56%)
Frame = +2
Query: 380 ICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYVTWKI 559
+ V A R + R+ N V++ + L Y T+LV+ +NPVD++T + +
Sbjct: 75 VAVRAAFTNTRAADVRMGGALTNAPVIRALATTLRGYQ-GTVLVV-TNPVDLMTRLFAET 132
Query: 560 SGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSAVNIAG 733
SG P RV G G+NLDSAR+R L+ L + T+ HG++IGEHGD +V S+ + G
Sbjct: 133 SGCP--RVYGIGSNLDSARYRLTLAHLLDVPATTVHGHVIGEHGDGAVVCASSTTVNG 188
>UniRef50_Q2FPC3 Cluster: Lactate/malate dehydrogenase; n=2;
Methanomicrobiales|Rep: Lactate/malate dehydrogenase -
Methanospirillum hungatei (strain JF-1 / DSM 864)
Length = 290
Score = 76.6 bits (180), Expect = 8e-13
Identities = 43/117 (36%), Positives = 67/117 (57%), Gaps = 1/117 (0%)
Frame = +2
Query: 380 ICVVTAGV-RQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYVTWK 556
I + AG+ R + ++R L+ N V ++ + Y I+++ +NP DILTY WK
Sbjct: 67 IILYAAGLPRNQNIKTRAALLDCNVPVASELATLIPDYKG--IIIVVTNPADILTYYLWK 124
Query: 557 ISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSAVNI 727
G+ K+R+IG G LDSARF+Y LS + + G I+GEHG+ VP++S +
Sbjct: 125 SLGILKNRIIGFGGQLDSARFQYELS----LRSIRDDGIILGEHGEHQVPIFSKTGL 177
>UniRef50_Q7MTK2 Cluster: Malate dehydrogenase; n=4;
Bacteroidales|Rep: Malate dehydrogenase - Porphyromonas
gingivalis (Bacteroides gingivalis)
Length = 334
Score = 75.8 bits (178), Expect = 1e-12
Identities = 57/166 (34%), Positives = 82/166 (49%), Gaps = 5/166 (3%)
Frame = +2
Query: 374 SKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPD-TILVIASNPVDILTYVT 550
+K V + G ++EG +R DL++ N ++ Q+ + Y PD ++I NP DI VT
Sbjct: 75 AKYIVSSGGAPRKEGMTREDLLKGNAEIAAQLGKDIKSYCPDCKHVIIIFNPADITGLVT 134
Query: 551 WKISGLPKHRVIGSGTNLDSARFRYLLSDRLGI---ATTSCHGYIIGEHGDSSVPVWSAV 721
SGL K + + LDS R + L+ GI T+ Y G HG+ S
Sbjct: 135 LIYSGL-KPSQVTTLAGLDSTRLQSELAKHFGIKQSLVTNTRTY--GGHGEQMAVFASTA 191
Query: 722 NIAGVRLSDLNNQIGTDD-DPENWKELHENVVKSAYXVIKLKGYTS 856
+ G L+DL IGTD E W EL + VVK +IKL+G +S
Sbjct: 192 KVNGTPLTDL---IGTDKLTNEQWAELKQRVVKGGANIIKLRGRSS 234
>UniRef50_Q5FIY9 Cluster: L-LDH; n=6; Lactobacillus|Rep: L-LDH -
Lactobacillus acidophilus
Length = 304
Score = 75.4 bits (177), Expect = 2e-12
Identities = 41/125 (32%), Positives = 71/125 (56%), Gaps = 1/125 (0%)
Frame = +2
Query: 503 ILVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIG 682
+L+ SNP D + + + +GL K++V+G+GT LD+AR + ++ ++LG + G+++G
Sbjct: 115 VLLNISNPCDAVAQILQETTGLSKNQVLGTGTFLDTARMQRIIGEKLGQDPKNVEGWVLG 174
Query: 683 EHGDSSVPVWSAVNIAGVRLSDLNNQIGTDDDPEN-WKELHENVVKSAYXVIKLKGYTSX 859
EHG S WS V + NN+I EN ++L++ K+++ V KGYTS
Sbjct: 175 EHGSSQFIAWSTVRV--------NNKIAIQLFSENEQRKLNKVPNKNSFVVANGKGYTSY 226
Query: 860 GXSDC 874
+ C
Sbjct: 227 AIATC 231
>UniRef50_Q8IE66 Cluster: Oxidoreductase, putative; n=6;
Plasmodium|Rep: Oxidoreductase, putative - Plasmodium
falciparum (isolate 3D7)
Length = 334
Score = 74.5 bits (175), Expect = 3e-12
Identities = 42/135 (31%), Positives = 71/135 (52%), Gaps = 6/135 (4%)
Frame = +2
Query: 374 SKICVVTAGVRQRE----GESRLD--LVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDI 535
S + VVT V +RE E L+ + N +LK++ L K+ P +V+ ++PVD
Sbjct: 75 SLVVVVTIEVSEREFAEFDEEDLEKQVYTSNVKLLKEVAKSLKKHCPQAFVVVTTSPVDC 134
Query: 536 LTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 715
+ V + + +P H++ G L SAR R+ L+++L + G++IG HGD VP+
Sbjct: 135 MAKVLQEHANIPPHKICGMAGVLHSARLRHNLAEKLRVNPGDVQGFVIGAHGDKMVPLPR 194
Query: 716 AVNIAGVRLSDLNNQ 760
+ G+ LSD +
Sbjct: 195 YCCVNGIPLSDFTKK 209
>UniRef50_A2SNY0 Cluster: Malate/lactate dehydrogenases-like
protein; n=1; Methylibium petroleiphilum PM1|Rep:
Malate/lactate dehydrogenases-like protein - Methylibium
petroleiphilum (strain PM1)
Length = 432
Score = 72.9 bits (171), Expect = 1e-11
Identities = 49/171 (28%), Positives = 82/171 (47%)
Frame = +2
Query: 329 NAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTIL 508
+ ++ S D AG++ V+TAG ++ G SR DL N +++ + + ++P++ L
Sbjct: 178 STRLSGSDDLVALAGAEYIVITAGKPRQPGMSRTDLTVVNAEIMTSVCRGIRTHAPNSTL 237
Query: 509 VIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEH 688
VI SNP++ +T++ + +G P+ RV+G LDSARF L+ +G H
Sbjct: 238 VIVSNPLEEMTHLAAQQTGFPEERVLGMAGVLDSARFCALVGLTGKARPQEVRAVALGSH 297
Query: 689 GDSSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKL 841
G V S + + I + D E K L E +S V+KL
Sbjct: 298 GPEMVIPLSQAFVG-------DRPIESMFDAETLKALVERARESGGEVVKL 341
>UniRef50_Q88ZG9 Cluster: L-2-hydroxyisocaproate dehydrogenase; n=2;
Lactobacillus plantarum|Rep: L-2-hydroxyisocaproate
dehydrogenase - Lactobacillus plantarum
Length = 319
Score = 72.5 bits (170), Expect = 1e-11
Identities = 38/140 (27%), Positives = 71/140 (50%)
Frame = +2
Query: 455 VLKQIIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLS 634
+++ I P++ + +++ NP D +T+ + +GL + +V G+GT LD+AR + +++
Sbjct: 100 IVQDIAPKVKATKFNGVVIDTMNPCDAITHYFQRATGLSRQQVFGTGTFLDTARMQKVVA 159
Query: 635 DRLGIATTSCHGYIIGEHGDSSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVV 814
+ + GY+ GEHG+S WS V + G+ ++ L ++ D D H
Sbjct: 160 EAFDCDPKNISGYVYGEHGESQFSAWSTVQVNGIPITSLVDKYHLDLDALEAAARH---- 215
Query: 815 KSAYXVIKLKGYTSXGXSDC 874
+ V KGYTS + C
Sbjct: 216 -GGWAVHSGKGYTSFAIATC 234
>UniRef50_A5IYS9 Cluster: L-lactate dehydrogenase; n=2;
Mycoplasma|Rep: L-lactate dehydrogenase - Mycoplasma
agalactiae
Length = 323
Score = 72.5 bits (170), Expect = 1e-11
Identities = 41/162 (25%), Positives = 79/162 (48%), Gaps = 1/162 (0%)
Frame = +2
Query: 380 ICVVTAGV-RQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYVTWK 556
+ V+TA + + R+ L N +++ L I+V+A+NP D++
Sbjct: 74 VVVITASIPADKTFSDRMALAGANAKLMQSFAKDLDAAGFKGIVVVAANPCDVMAAAVHY 133
Query: 557 ISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSAVNIAGV 736
S +P +RVI +GTNL++ R + +L+ + + + ++GEHG +++ WS V +
Sbjct: 134 GSKIPANRVISAGTNLETGRLKKMLAAKFNTSPDAIRASVLGEHGATAMIAWSTVKVGET 193
Query: 737 RLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
L L E+++E+ + V+ A+ + KG T G
Sbjct: 194 TLEGLVE--SGKITKEDYEEVLKQVIAEAFYIWSRKGNTQFG 233
>UniRef50_A3CTN0 Cluster: Lactate/malate dehydrogenase; n=1;
Methanoculleus marisnigri JR1|Rep: Lactate/malate
dehydrogenase - Methanoculleus marisnigri (strain ATCC
35101 / DSM 1498 / JR1)
Length = 288
Score = 70.9 bits (166), Expect = 4e-11
Identities = 44/124 (35%), Positives = 72/124 (58%), Gaps = 1/124 (0%)
Frame = +2
Query: 347 STDYSITAGSKICVVTAGV-RQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASN 523
ST+ + + I V AG R + ++R DL++ N V K+ +L++ P ++ + +N
Sbjct: 56 STETAAMRDADIFVFAAGTPRTPDIKTRADLLEANIPVAKRC-SELLEGFPGVVISV-TN 113
Query: 524 PVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSV 703
P+D Y WK+ G+ + R IG G+ LDSARF L + +GI + +++GEHGD V
Sbjct: 114 PMDANNYGLWKMMGIDRRRCIGFGSQLDSARFAGFLRE-VGIPGPA---WVLGEHGDRQV 169
Query: 704 PVWS 715
PV+S
Sbjct: 170 PVFS 173
>UniRef50_Q034P5 Cluster: Enzyme with possible activities of L-2-
hydroxyisocaproate/malate/lactate dehydrogenase; n=1;
Lactobacillus casei ATCC 334|Rep: Enzyme with possible
activities of L-2- hydroxyisocaproate/malate/lactate
dehydrogenase - Lactobacillus casei (strain ATCC 334)
Length = 301
Score = 69.3 bits (162), Expect = 1e-10
Identities = 48/170 (28%), Positives = 81/170 (47%)
Frame = +2
Query: 353 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 532
D I+A I ++ G R GE++ V L + P+L +L+ +NP D
Sbjct: 72 DVVISAVGNIGAISNG--DRIGETKTSKV-----ALDDVAPKLKASGFHGVLLDITNPCD 124
Query: 533 ILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVW 712
+T + LPK ++IG+GT+LD+ R R ++D L + GY +GEHG+S W
Sbjct: 125 AVTSYWQYLLDLPKSQIIGTGTSLDTYRMRRAVADTLHVNVADVRGYNMGEHGESQFTAW 184
Query: 713 SAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIKLKGYTSXG 862
S V + NN+ + ++ +L ++ + + + K YTS G
Sbjct: 185 STVRV--------NNEPIAEYAKVDYDQLADDARAGGWKIYQAKHYTSYG 226
>UniRef50_A2SR33 Cluster: Lactate/malate dehydrogenase; n=1;
Methanocorpusculum labreanum Z|Rep: Lactate/malate
dehydrogenase - Methanocorpusculum labreanum (strain
ATCC 43576 / DSM 4855 / Z)
Length = 283
Score = 64.5 bits (150), Expect = 3e-09
Identities = 42/131 (32%), Positives = 72/131 (54%), Gaps = 1/131 (0%)
Frame = +2
Query: 338 IQSSTDYSITAGSKICVVTAGV-RQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVI 514
I ST+ + + C+ +AG R ++R DL +N + K+ L +S L++
Sbjct: 52 IPVSTNPADLKDADYCIFSAGYSRSPNIKTRADLFDKNLPIAKESSELLKGFSGK--LIV 109
Query: 515 ASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGD 694
+NP+D+ T+ K S L + +V+G G LDS RF +L +GI G ++GEHG+
Sbjct: 110 VTNPMDVFTWYFAKKSCLDESQVVGFGGLLDSRRFTVVLRS-IGI---EAEGQVLGEHGE 165
Query: 695 SSVPVWSAVNI 727
VP++S+++I
Sbjct: 166 HQVPLFSSLDI 176
>UniRef50_Q64YY6 Cluster: Malate dehydrogenase; n=5;
Bacteroidales|Rep: Malate dehydrogenase - Bacteroides
fragilis
Length = 333
Score = 58.4 bits (135), Expect = 2e-07
Identities = 46/168 (27%), Positives = 80/168 (47%), Gaps = 5/168 (2%)
Frame = +2
Query: 368 AGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDT-ILVIASNPVDILTY 544
+G+K V + G ++ G +R DL++ N ++ Q + +Y PD +V+ NP DI
Sbjct: 73 SGAKYIVSSGGAARKAGMTREDLLKGNAEIAAQFGKDIRQYCPDVKHVVVVFNPADITGL 132
Query: 545 VTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATT---SCHGYIIGEHGDSSVPVWS 715
+ +GL K + + LDS R + L L I + +C Y G HG+ S
Sbjct: 133 IVLLYAGL-KPSQVSTLAALDSTRLQNELVKYLHIPASEIVNCRTY--GGHGEQMAVFAS 189
Query: 716 AVNIAGVRLSDLNNQIGTDDDP-ENWKELHENVVKSAYXVIKLKGYTS 856
+ G L+ + I T P ++W++L V++ +I L+G +S
Sbjct: 190 TTKVQGEALTKI---IDTPRMPMQDWEDLKVRVIQGGKHIIDLRGRSS 234
>UniRef50_Q1U8H4 Cluster: L-lactate dehydrogenase; n=2;
Lactobacillus reuteri|Rep: L-lactate dehydrogenase -
Lactobacillus reuteri 100-23
Length = 307
Score = 57.2 bits (132), Expect = 5e-07
Identities = 32/131 (24%), Positives = 64/131 (48%)
Frame = +2
Query: 353 DYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVD 532
DY+ A + + + G + + ++ + Q+ ++ K IL+ +NP +
Sbjct: 63 DYAALADADVLITAFGKSALMKQQPMAELETSYQQALQVGNKVFKSDFSGILINLTNPNE 122
Query: 533 ILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVW 712
+T V + GLP+ +VIG GT +++AR +++ +A + G++ G+H V W
Sbjct: 123 AITAVLQQKVGLPQKQVIGIGTVVETARLYRAIAEAAKVAAANVTGFVYGQHDGHQVFAW 182
Query: 713 SAVNIAGVRLS 745
S V + G L+
Sbjct: 183 STVRVNGQPLT 193
>UniRef50_Q86S07 Cluster: NAD-specific malate dehydrogenase 2; n=1;
Entamoeba histolytica|Rep: NAD-specific malate
dehydrogenase 2 - Entamoeba histolytica
Length = 329
Score = 53.2 bits (122), Expect = 8e-06
Identities = 35/126 (27%), Positives = 61/126 (48%), Gaps = 3/126 (2%)
Frame = +2
Query: 338 IQSSTDYSITAGS-KICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYS-PDTILV 511
I S+T+ ++ + + ++ AGV ++ G R DL+ N V++ L YS D +V
Sbjct: 75 IISTTEIALAFSNVDVAIIVAGVPRKPGMQRSDLINVNKKVMEMNGKALGTYSNKDVRVV 134
Query: 512 IASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYII-GEH 688
+ +NP + YV K SG+P + T LD R +++ +G H I+ G H
Sbjct: 135 VVANPANTNAYVICKTSGIPPEHITAL-TRLDQNRATAFVANEVGCQPEFVHNIIVWGNH 193
Query: 689 GDSSVP 706
++ P
Sbjct: 194 SNTMQP 199
>UniRef50_Q5ENS5 Cluster: Malate dehydrogenase; n=1; Heterocapsa
triquetra|Rep: Malate dehydrogenase - Heterocapsa
triquetra (Dinoflagellate)
Length = 402
Score = 51.2 bits (117), Expect = 3e-05
Identities = 42/145 (28%), Positives = 72/145 (49%), Gaps = 11/145 (7%)
Frame = +2
Query: 371 GSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYV- 547
G + ++ AG+ ++ G++R DL + N D+ K I+ KY PD +L + NPV+ +
Sbjct: 158 GCHLVLIPAGMPRKPGQTRDDLFKINADIAKGIVEACAKYCPDAMLGMIVNPVNSVVPAM 217
Query: 548 --TWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEH-GDSSVPVWS- 715
+K GL +++G T LD R + RL + +IG H G + +P++S
Sbjct: 218 AELYKKKGLDPMKIVGI-TTLDVVRANKFVV-RLPAPPDRVNVPVIGGHAGTTILPLFSQ 275
Query: 716 ---AVNIAGVRLSDLNNQI---GTD 772
A I ++ DL+ + GTD
Sbjct: 276 DKHAKTIDAEKIPDLDKHVQDAGTD 300
>UniRef50_Q8Y860 Cluster: Lmo1057 protein; n=11; Listeria|Rep:
Lmo1057 protein - Listeria monocytogenes
Length = 317
Score = 50.8 bits (116), Expect = 5e-05
Identities = 25/109 (22%), Positives = 60/109 (55%)
Frame = +2
Query: 407 QREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVI 586
Q E +++ + N ++ + + +++ I+++A+ +++ + + SGL +++I
Sbjct: 77 QEEMSNQIVSKEDNVALIIEKVKKMMATGFRGIVLVATAESNVVAALIKRFSGLSANQII 136
Query: 587 GSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSAVNIAG 733
GT L ++ F+ ++ I+ + HGYIIG++ + +PVWS + G
Sbjct: 137 TLGTMLATSYFQVEIAKLFKISPKNVHGYIIGDNAEDVIPVWSRAFLGG 185
>UniRef50_A7TL95 Cluster: Putative uncharacterized protein; n=1;
Vanderwaltozyma polyspora DSM 70294|Rep: Putative
uncharacterized protein - Vanderwaltozyma polyspora DSM
70294
Length = 365
Score = 47.6 bits (108), Expect = 4e-04
Identities = 35/100 (35%), Positives = 58/100 (58%), Gaps = 5/100 (5%)
Frame = +2
Query: 359 SITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSP-DTILVIASNPVDI 535
++ GS++ +VTAG+ ++ G +R DL + N +++ + + K++P L+I SNPV+
Sbjct: 66 NLLEGSELVIVTAGIPRKPGMTRDDLFKINAKIIQNLTVKYAKFAPVHCKLLIISNPVNS 125
Query: 536 LTYV---TWKISG-LPKHRVIGSGTNLDSARFRYLLSDRL 643
L V T KI+G L +V G T LD R + L+D L
Sbjct: 126 LIPVVIETLKINGRLNPSQVFGI-TMLDIIRSQTFLNDLL 164
>UniRef50_Q4Q3J3 Cluster: Malate dehydrogenase, putative; n=3;
Leishmania|Rep: Malate dehydrogenase, putative -
Leishmania major
Length = 331
Score = 46.8 bits (106), Expect = 7e-04
Identities = 32/119 (26%), Positives = 62/119 (52%), Gaps = 4/119 (3%)
Frame = +2
Query: 371 GSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYV- 547
G+ + +++AG+ +R G + DL N + ++ + +Y+P ++L I SNP++ + V
Sbjct: 75 GADLVLMSAGMPRRPGMTHDDLFNTNALTVNELSAAVARYAPKSVLAIISNPLNSMVPVA 134
Query: 548 --TWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEH-GDSSVPVWS 715
T + +G+ R + +L+ R R +L D G +IG H G + VP++S
Sbjct: 135 AETLQRAGVYDPRKLFGIISLNMMRARKMLGDFTGQDPEMLDVPVIGGHSGQTIVPLFS 193
>UniRef50_Q039N1 Cluster: Malate/lactate dehydrogenase; n=1;
Lactobacillus casei ATCC 334|Rep: Malate/lactate
dehydrogenase - Lactobacillus casei (strain ATCC 334)
Length = 296
Score = 45.2 bits (102), Expect = 0.002
Identities = 29/116 (25%), Positives = 55/116 (47%), Gaps = 2/116 (1%)
Frame = +2
Query: 431 DLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDS 610
D ++ N +++++ + +++A ++ TY + SG+ K +V+G GT +
Sbjct: 81 DFIETNIAAIRKVLNSAMAAGFTGRIIVAMTRDELFTYFAQRFSGVNKSQVVGLGTFGAT 140
Query: 611 ARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSAVNIAGVR-LSDLNNQ-IGTD 772
RF L+ RL + Y++G + V +WS + L LN+Q I TD
Sbjct: 141 WRFEQFLAARLAVPAKHVTAYVVGTR-QAPVLIWSRAYVGATPVLRLLNDQTIFTD 195
>UniRef50_Q1WU75 Cluster: Lactate/malate dehydrogenase; n=1;
Lactobacillus salivarius subsp. salivarius UCC118|Rep:
Lactate/malate dehydrogenase - Lactobacillus salivarius
subsp. salivarius (strain UCC118)
Length = 294
Score = 43.2 bits (97), Expect = 0.009
Identities = 29/109 (26%), Positives = 55/109 (50%)
Frame = +2
Query: 425 RLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVIGSGTNL 604
R + Q+N+ + K ++ + + + I+V+ SN +L K +GL +V+G GT++
Sbjct: 80 RDNFAQKNSWIQK-VVTEAVANGFNGIVVLDSNKDYLLINEILKYTGLSSRQVLGLGTSI 138
Query: 605 DSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSAVNIAGVRLSDL 751
+S +++ +LGI + +IG D S +WS +A L L
Sbjct: 139 ESEVVARMVAKKLGINSNYIQTSVIGTR-DKSFVLWSKGRVAEASLMSL 186
>UniRef50_UPI0000DB76D8 Cluster: PREDICTED: similar to CG7998-PA;
n=2; Apis mellifera|Rep: PREDICTED: similar to CG7998-PA
- Apis mellifera
Length = 333
Score = 41.9 bits (94), Expect = 0.021
Identities = 28/119 (23%), Positives = 59/119 (49%), Gaps = 4/119 (3%)
Frame = +2
Query: 371 GSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYVT 550
G+KI ++ V R ++++ N +L ++P +IK+SP +L I NP++ L +T
Sbjct: 70 GAKIVMI---VTDRTSNESNEVLKSNAIILSDLLPNIIKFSPQAMLAIVMNPINSLIPLT 126
Query: 551 ---WKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEH-GDSSVPVWS 715
+K +G+ ++ I N + + +D + I +IG ++ +P++S
Sbjct: 127 MEMYKKAGIYEYNRIFGVMNFECLKANSFTADLINIEPECTMIPVIGGGCSETCIPLFS 185
>UniRef50_Q03QL8 Cluster: Malate/lactate dehydrogenase; n=1;
Lactobacillus brevis ATCC 367|Rep: Malate/lactate
dehydrogenase - Lactobacillus brevis (strain ATCC 367 /
JCM 1170)
Length = 302
Score = 41.9 bits (94), Expect = 0.021
Identities = 26/84 (30%), Positives = 41/84 (48%), Gaps = 4/84 (4%)
Frame = +2
Query: 536 LTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 715
L+Y WK SGL +++ G GT + L+D LG+ + + +IG D + VWS
Sbjct: 117 LSYFAWKFSGLQANQIWGLGTYPLARLLTARLADHLGVGSAAVQATVIGT-ADLPIVVWS 175
Query: 716 AVNIAGV----RLSDLNNQIGTDD 775
I V L++ + +I DD
Sbjct: 176 RTYIGPVPILMYLANADTKISADD 199
>UniRef50_P40925 Cluster: Malate dehydrogenase, cytoplasmic; n=124;
cellular organisms|Rep: Malate dehydrogenase,
cytoplasmic - Homo sapiens (Human)
Length = 334
Score = 40.7 bits (91), Expect = 0.048
Identities = 32/124 (25%), Positives = 56/124 (45%), Gaps = 3/124 (2%)
Frame = +2
Query: 380 ICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTI-LVIASNPVDILTYVTWK 556
+ ++ + +REG R DL++ N + K L KY+ ++ +++ NP + K
Sbjct: 83 VAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASK 142
Query: 557 IS-GLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYII-GEHGDSSVPVWSAVNIA 730
+ +PK T LD R + ++ +LG+ II G H + P VN A
Sbjct: 143 SAPSIPKEN-FSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYP---DVNHA 198
Query: 731 GVRL 742
V+L
Sbjct: 199 KVKL 202
>UniRef50_Q9VU29 Cluster: Malate dehydrogenase; n=5;
Protostomia|Rep: Malate dehydrogenase - Drosophila
melanogaster (Fruit fly)
Length = 347
Score = 40.3 bits (90), Expect = 0.064
Identities = 29/116 (25%), Positives = 53/116 (45%), Gaps = 4/116 (3%)
Frame = +2
Query: 380 ICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYVT--- 550
I V+ AG+ ++ G R DLV N V ++ + P +L +NP++++ +
Sbjct: 98 IVVIPAGLPRKPGMKREDLVDVNASVACEVAFAASEVCPGAMLAFITNPINVIVPIVATI 157
Query: 551 WKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEH-GDSSVPVWS 715
K G + T LD R + ++D L + + +IG H G + +P+ S
Sbjct: 158 LKAKGTYDPNRLFGVTTLDVVRAQTFVADILNVDPQKVNIPVIGGHTGRTILPILS 213
>UniRef50_Q5NDY3 Cluster: Putative l-lactate dehydrogenase; n=1;
Lactobacillus sanfranciscensis|Rep: Putative l-lactate
dehydrogenase - Lactobacillus sanfranciscensis
(Lactobacillus sanfrancisco)
Length = 92
Score = 39.9 bits (89), Expect = 0.085
Identities = 24/72 (33%), Positives = 31/72 (43%)
Frame = +2
Query: 647 IATTSCHGYIIGEHGDSSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAY 826
+A H Y++GEHGDS I V L D + G E+ EL + AY
Sbjct: 15 LAPEVVHAYVLGEHGDSEFADLDEATIGNVPLLDYAAKRGV--SKEDLLELEDKTRNKAY 72
Query: 827 XVIKLKGYTSXG 862
+I KG T G
Sbjct: 73 SIINKKGATFYG 84
>UniRef50_Q6CP51 Cluster: Similar to sp|P22133 Saccharomyces
cerevisiae YOL126c MDH2 malate dehydrogenase; n=1;
Kluyveromyces lactis|Rep: Similar to sp|P22133
Saccharomyces cerevisiae YOL126c MDH2 malate
dehydrogenase - Kluyveromyces lactis (Yeast) (Candida
sphaerica)
Length = 404
Score = 37.9 bits (84), Expect = 0.34
Identities = 36/130 (27%), Positives = 63/130 (48%), Gaps = 12/130 (9%)
Frame = +2
Query: 368 AGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSP--DTILVIASNPVDIL- 538
+ + + ++ AGV ++ G SR DL+ N ++K + + KY +++ SNP++ L
Sbjct: 127 SNASVVIIPAGVPRKPGMSRDDLIGVNAKIIKSLGEDIAKYCDLNKVHVLVISNPINSLV 186
Query: 539 -----TYVTWKISGLP--KHRVIGSGTNLDSARFRYLLSDRLGI-ATTSCHGYIIGEH-G 691
T + +G + RV G T LD R + G + TS +IG H G
Sbjct: 187 PLLTNTLIRSDANGNSNIESRVYGI-TQLDLVRSSTFVQQLNGFKSNTSPVIPVIGGHSG 245
Query: 692 DSSVPVWSAV 721
D+ +PV+S +
Sbjct: 246 DTIIPVFSTL 255
>UniRef50_Q01JC3 Cluster: Malate dehydrogenase; n=8; cellular
organisms|Rep: Malate dehydrogenase - Oryza sativa
(Rice)
Length = 352
Score = 37.1 bits (82), Expect = 0.60
Identities = 26/125 (20%), Positives = 55/125 (44%), Gaps = 2/125 (1%)
Frame = +2
Query: 338 IQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKY-SPDTILVI 514
+ +S + G + ++ G +R+G R DL+ +N + K L ++ +P+ +++
Sbjct: 91 VATSDEAEAFKGVNVAILIGGWPRRDGMERKDLISKNVTIYKSQASALQQHAAPNCKVLV 150
Query: 515 ASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYII-GEHG 691
+NP + V + + + I T LD R ++++L + II G H
Sbjct: 151 VANPANTNALVLKEFAPAIPAKNITCLTRLDHNRALGQVAEKLNVHVGDVKNAIIWGNHS 210
Query: 692 DSSVP 706
+ P
Sbjct: 211 STQFP 215
>UniRef50_A5I533 Cluster: Putative malate/lactate dehydrogenase;
n=4; Clostridium botulinum|Rep: Putative malate/lactate
dehydrogenase - Clostridium botulinum A str. ATCC 3502
Length = 407
Score = 34.7 bits (76), Expect = 3.2
Identities = 26/83 (31%), Positives = 37/83 (44%)
Frame = +2
Query: 503 ILVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIG 682
I I S+PVD+L K GL +V G G + SAR Y S G G
Sbjct: 238 IFAIVSDPVDLLCKSALK-EGLAPEQVRGYGLGVMSARAAYYADKDPKFKNYSMEGRAFG 296
Query: 683 EHGDSSVPVWSAVNIAGVRLSDL 751
HG+ V + ++++ LSD+
Sbjct: 297 PHGEGLV-IANSIDNYDENLSDI 318
>UniRef50_UPI0000499B99 Cluster: protein kinase; n=3; Entamoeba
histolytica HM-1:IMSS|Rep: protein kinase - Entamoeba
histolytica HM-1:IMSS
Length = 1708
Score = 34.3 bits (75), Expect = 4.2
Identities = 17/49 (34%), Positives = 27/49 (55%)
Frame = -1
Query: 446 FSARDRDEIHLRVVEHQQ*PRRSSSQLL*NNPY*IGSWRFLMNADPCCR 300
F+ D E + RV++ ++ + +LL NN Y IG F++N DP R
Sbjct: 1598 FAIADVGEFYFRVLKSEELLTEENKELLGNNEYLIGFLEFVLNRDPTKR 1646
>UniRef50_A2YRW8 Cluster: Putative uncharacterized protein; n=2;
Oryza sativa|Rep: Putative uncharacterized protein -
Oryza sativa subsp. indica (Rice)
Length = 127
Score = 34.3 bits (75), Expect = 4.2
Identities = 18/46 (39%), Positives = 31/46 (67%), Gaps = 4/46 (8%)
Frame = +2
Query: 422 SRLDLVQRN--TDVLKQIIPQLIKYSPDTILVIASNPV--DILTYV 547
++L+L++ N +L +I+P L + SP+ LV+ S+P D+LTYV
Sbjct: 3 TKLELMRSNYLKKLLTEIVPALAENSPEAALVVVSDPPVDDVLTYV 48
>UniRef50_Q8EYH1 Cluster: Methyl-accepting chemotaxis protein; n=2;
Leptospira interrogans|Rep: Methyl-accepting chemotaxis
protein - Leptospira interrogans
Length = 530
Score = 33.9 bits (74), Expect = 5.6
Identities = 20/55 (36%), Positives = 33/55 (60%), Gaps = 1/55 (1%)
Frame = -3
Query: 594 PDPMTRCLGSPLIFHVTYVRI-STGLLAITNIVSGLYFISCGIICLSTSVFLCTR 433
PD T + SP+++ ++Y+ I S+GLL + N V + F+S G L ++F TR
Sbjct: 105 PDFTTGVVKSPILYGISYMYIVSSGLLLVPNFVLWIGFLSGGAQAL--AIFTATR 157
>UniRef50_A0W7C0 Cluster: Diguanylate cyclase/phosphodiesterase with
PAS/PAC sensor; n=2; cellular organisms|Rep: Diguanylate
cyclase/phosphodiesterase with PAS/PAC sensor -
Geobacter lovleyi SZ
Length = 1027
Score = 33.9 bits (74), Expect = 5.6
Identities = 22/72 (30%), Positives = 36/72 (50%), Gaps = 1/72 (1%)
Frame = +2
Query: 407 QREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNP-VDILTYVTWKISGLPKHRV 583
QRE ++ V++ +Q + +I + PD + VI N V I K+SG+PK +
Sbjct: 318 QREQLAKARAVEQALLDARQQLNDIIDFFPDAVFVIDRNKRVTIWNRAIEKMSGVPKEEM 377
Query: 584 IGSGTNLDSARF 619
+G G + S F
Sbjct: 378 LGKGDHEYSIPF 389
>UniRef50_Q15QV8 Cluster: Putative uncharacterized protein; n=1;
Pseudoalteromonas atlantica T6c|Rep: Putative
uncharacterized protein - Pseudoalteromonas atlantica
(strain T6c / BAA-1087)
Length = 295
Score = 33.5 bits (73), Expect = 7.4
Identities = 32/108 (29%), Positives = 48/108 (44%), Gaps = 3/108 (2%)
Frame = +2
Query: 326 GNAKIQSSTDYSITAGSKICVVTAGVRQREGESRLD--LVQRNTDVLKQIIPQLIKYSPD 499
G I + AG + V G Q ++ L+ + + +IPQLI+
Sbjct: 94 GGLDIDNPVGKHAIAGVRQVVAKRGEVQLPPRDKISYHLIVKQNALFTALIPQLIQQF-- 151
Query: 500 TILVIASNPVDILTYVTWKISGLPKHR-VIGSGTNLDSARFRYLLSDR 640
+IL I NPVD+L ++W LP +R I +G D A R L D+
Sbjct: 152 SILCIVRNPVDVL--LSWFTVDLPVNRGHIPAGERFDEA-LRLSLQDK 196
>UniRef50_A3YGJ3 Cluster: Beta-ketoacyl synthase; n=1; Marinomonas
sp. MED121|Rep: Beta-ketoacyl synthase - Marinomonas sp.
MED121
Length = 714
Score = 33.5 bits (73), Expect = 7.4
Identities = 15/68 (22%), Positives = 31/68 (45%)
Frame = +2
Query: 659 SCHGYIIGEHGDSSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYXVIK 838
+CH +++GE +S W NI ++ L G+ P+ H N++++ +++
Sbjct: 143 ACHQFVVGEEAINSAAQWVMPNINAETVAYLQYSSGSTGSPKGVMLGHGNLIQNTALIVQ 202
Query: 839 LKGYTSXG 862
T G
Sbjct: 203 ELSLTECG 210
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 761,268,638
Number of Sequences: 1657284
Number of extensions: 14426451
Number of successful extensions: 42388
Number of sequences better than 10.0: 157
Number of HSP's better than 10.0 without gapping: 40608
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 42340
length of database: 575,637,011
effective HSP length: 100
effective length of database: 409,908,611
effective search space used: 79932179145
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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