Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fcaL-P29_F_L20
(847 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_A5A7A0 Cluster: Mevalonate kinase; n=1; Bombyx mori|Rep... 273 3e-72
UniRef50_UPI00015B4200 Cluster: PREDICTED: similar to mevalonate... 71 5e-11
UniRef50_UPI0000D56452 Cluster: PREDICTED: similar to mevalonate... 71 5e-11
UniRef50_UPI0000587FA1 Cluster: PREDICTED: similar to Mevalonate... 66 1e-09
UniRef50_A7SJK4 Cluster: Predicted protein; n=1; Nematostella ve... 63 7e-09
UniRef50_UPI0000E810F5 Cluster: PREDICTED: hypothetical protein;... 57 6e-07
UniRef50_UPI000155619E Cluster: PREDICTED: hypothetical protein,... 55 2e-06
UniRef50_A3LQ81 Cluster: Mevalonate kinase; n=5; Saccharomycetal... 55 2e-06
UniRef50_Q65XX9 Cluster: Putative uncharacterized protein; n=5; ... 55 3e-06
UniRef50_Q03426 Cluster: Mevalonate kinase; n=26; Euteleostomi|R... 54 3e-06
UniRef50_Q6CEF6 Cluster: Yarrowia lipolytica chromosome B of str... 54 6e-06
UniRef50_UPI0000DB6B27 Cluster: PREDICTED: similar to Mevalonate... 52 1e-05
UniRef50_Q7PWI8 Cluster: ENSANGP00000021364; n=2; Culicidae|Rep:... 52 2e-05
UniRef50_Q0UWF5 Cluster: Putative uncharacterized protein; n=1; ... 52 2e-05
UniRef50_Q4WP25 Cluster: Mevalonate kinase; n=15; Pezizomycotina... 50 7e-05
UniRef50_Q86AG7 Cluster: Similar to Rattus norvegicus (Rat). Mev... 49 1e-04
UniRef50_Q4TG59 Cluster: Chromosome undetermined SCAF3891, whole... 49 2e-04
UniRef50_A2SR97 Cluster: Mevalonate kinase; n=4; Methanomicrobia... 48 4e-04
UniRef50_Q09780 Cluster: Putative mevalonate kinase; n=1; Schizo... 47 5e-04
UniRef50_Q8TT37 Cluster: Mevalonate kinase; n=5; Euryarchaeota|R... 46 0.001
UniRef50_P07277 Cluster: Mevalonate kinase; n=3; Saccharomycetal... 46 0.001
UniRef50_Q50559 Cluster: Mevalonate kinase; n=2; Methanothermoba... 46 0.001
UniRef50_Q0LHN3 Cluster: Mevalonate kinase; n=2; Chloroflexi (cl... 46 0.002
UniRef50_A0B6E3 Cluster: Mevalonate kinase; n=1; Methanosaeta th... 46 0.002
UniRef50_Q9V187 Cluster: Mevalonate kinase; n=4; Thermococcaceae... 46 0.002
UniRef50_Q58487 Cluster: Mevalonate kinase; n=1; Methanocaldococ... 44 0.004
UniRef50_Q7K2V9 Cluster: GH04687p; n=1; Drosophila melanogaster|... 44 0.005
UniRef50_Q756D2 Cluster: AER335Wp; n=3; Saccharomycetaceae|Rep: ... 44 0.005
UniRef50_O27995 Cluster: Mevalonate kinase; n=1; Archaeoglobus f... 44 0.005
UniRef50_UPI000155611C Cluster: PREDICTED: hypothetical protein,... 44 0.006
UniRef50_Q9HQI6 Cluster: Mevalonate kinase; n=5; Halobacteriacea... 43 0.008
UniRef50_Q2HTL9 Cluster: Mevalonate and galactokinase; n=5; core... 43 0.011
UniRef50_A1RYL2 Cluster: Mevalonate kinase; n=1; Thermofilum pen... 43 0.011
UniRef50_P46086 Cluster: Mevalonate kinase; n=8; Magnoliophyta|R... 43 0.011
UniRef50_A5UV63 Cluster: Mevalonate kinase; n=3; Chloroflexaceae... 42 0.019
UniRef50_A2E1U7 Cluster: Mevalonate kinase family protein; n=1; ... 41 0.045
UniRef50_A7DRD8 Cluster: Mevalonate kinase; n=1; Candidatus Nitr... 41 0.045
UniRef50_UPI00015BB033 Cluster: mevalonate kinase; n=1; Ignicocc... 40 0.079
UniRef50_A3HYY0 Cluster: Galactokinase; n=1; Algoriphagus sp. PR... 40 0.079
UniRef50_Q2NG06 Cluster: Putative mevalonate kinase; n=1; Methan... 40 0.079
UniRef50_A5UN66 Cluster: Mevalonate kinase; n=1; Methanobrevibac... 40 0.079
UniRef50_A3H636 Cluster: Mevalonate kinase; n=1; Caldivirga maqu... 40 0.079
UniRef50_Q74JA4 Cluster: Mevalonate kinase; n=7; Lactobacillus|R... 40 0.10
UniRef50_Q2BIK0 Cluster: Mevalonate kinase, putative; n=1; Neptu... 40 0.10
UniRef50_Q8TWN9 Cluster: Mevalonate kinase; n=1; Methanopyrus ka... 39 0.14
UniRef50_Q6GN90 Cluster: MGC82947 protein; n=10; Euteleostomi|Re... 39 0.18
UniRef50_A2BL67 Cluster: Mevalonate kinase; n=1; Hyperthermus bu... 39 0.18
UniRef50_Q9Y946 Cluster: Mevalonate kinase; n=1; Aeropyrum perni... 39 0.18
UniRef50_Q8L1I1 Cluster: Phosphomevalonate kinase; n=1; Paracocc... 38 0.24
UniRef50_A6G140 Cluster: Hydroxymethylglutaryl-CoA reductase; n=... 38 0.24
UniRef50_Q9H3K6 Cluster: BolA-like protein 2; n=18; Deuterostomi... 38 0.32
UniRef50_Q8L1I2 Cluster: Mevalonate kinase; n=1; Paracoccus zeax... 38 0.42
UniRef50_A5EVP5 Cluster: GHMP kinase family protein; n=1; Dichel... 38 0.42
UniRef50_A5EUV5 Cluster: GHMP kinase family protein; n=1; Dichel... 38 0.42
UniRef50_Q6LXL5 Cluster: Mevalonate kinase; n=5; Methanococcus|R... 38 0.42
UniRef50_Q22LZ8 Cluster: ATPase, AAA family protein; n=1; Tetrah... 37 0.55
UniRef50_A0E671 Cluster: Chromosome undetermined scaffold_8, who... 37 0.55
UniRef50_UPI0000E24CC4 Cluster: PREDICTED: similar to bolA-like ... 36 0.97
UniRef50_Q7QVN5 Cluster: GLP_305_18405_19430; n=1; Giardia lambl... 36 0.97
UniRef50_Q83DT4 Cluster: Phosphomevalonate kinase, putative; n=2... 36 1.3
UniRef50_Q03FN7 Cluster: Mevalonate kinase; n=1; Pediococcus pen... 36 1.3
UniRef50_A6G138 Cluster: Mevalonate kinase; n=1; Plesiocystis pa... 36 1.3
UniRef50_A2U564 Cluster: Mevalonate kinase; n=1; Bacillus coagul... 36 1.7
UniRef50_A2DPP4 Cluster: Phosphatidylinositol 3-and 4-kinase fam... 35 2.2
UniRef50_Q6C8D7 Cluster: Yarrowia lipolytica chromosome D of str... 35 2.2
UniRef50_Q9FD69 Cluster: Mevalonate kinase; n=4; Enterococcus|Re... 35 3.0
UniRef50_Q2BIJ9 Cluster: GHMP kinase; n=1; Neptuniibacter caesar... 35 3.0
UniRef50_Q17N15 Cluster: Putative uncharacterized protein; n=1; ... 35 3.0
UniRef50_Q2GZQ7 Cluster: Putative uncharacterized protein; n=1; ... 35 3.0
UniRef50_Q97UL6 Cluster: (Phospho) mevalonate kinase, putative; ... 35 3.0
UniRef50_Q7XJS3 Cluster: At2g17440 protein; n=3; Brassicaceae|Re... 34 3.9
UniRef50_A3DL21 Cluster: Mevalonate kinase; n=1; Staphylothermus... 34 3.9
UniRef50_Q38X71 Cluster: Mevalonate kinase; n=1; Lactobacillus s... 34 5.2
UniRef50_A6GIJ2 Cluster: Putative uncharacterized protein; n=1; ... 34 5.2
UniRef50_A5VK03 Cluster: Mevalonate kinase; n=2; Lactobacillus r... 34 5.2
UniRef50_A4VT18 Cluster: Mevalonate kinase; n=4; Streptococcus|R... 34 5.2
UniRef50_Q0W4W9 Cluster: Predicted signal transduction histidine... 34 5.2
UniRef50_Q8F618 Cluster: Putative uncharacterized protein; n=2; ... 33 6.8
UniRef50_Q83DT3 Cluster: Mevalonate kinase, putative; n=3; Coxie... 33 6.8
UniRef50_Q8H912 Cluster: Putative zinc knuckle domain containing... 33 6.8
UniRef50_Q60ED2 Cluster: Putative uncharacterized protein OSJNBa... 33 6.8
UniRef50_Q8SQK4 Cluster: MEVALONATE KINASE; n=1; Encephalitozoon... 33 6.8
UniRef50_Q5KDZ6 Cluster: Putative uncharacterized protein; n=1; ... 33 6.8
UniRef50_UPI000155FB65 Cluster: PREDICTED: similar to BolA-like ... 33 9.0
UniRef50_Q08UJ8 Cluster: Mevalonate kinase; n=2; Cystobacterinea... 33 9.0
UniRef50_Q031R4 Cluster: Mevalonate kinase; n=3; Lactococcus lac... 33 9.0
UniRef50_Q6C026 Cluster: Similarity; n=1; Yarrowia lipolytica|Re... 33 9.0
UniRef50_Q8ZTT2 Cluster: Mevalonate kinase; n=4; Pyrobaculum|Rep... 33 9.0
>UniRef50_A5A7A0 Cluster: Mevalonate kinase; n=1; Bombyx mori|Rep:
Mevalonate kinase - Bombyx mori (Silk moth)
Length = 413
Score = 273 bits (670), Expect = 3e-72
Identities = 129/130 (99%), Positives = 129/130 (99%)
Frame = +2
Query: 458 GITGKFSWRLPHKIDHDYHLRRVEEYLHLIKPNFDSLPNNQKNSLRSFLYVFSGIFGSTY 637
GITGKFSWRLPHKIDHDYHLRRVEEYLHLIKPNFDSLPNNQKNSLRSFLYVFSGIFGSTY
Sbjct: 87 GITGKFSWRLPHKIDHDYHLRRVEEYLHLIKPNFDSLPNNQKNSLRSFLYVFSGIFGSTY 146
Query: 638 LPVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQLLKLKSSSGNFDAYYDQSSQXFTD 817
LPVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQLLKLKSSSGNFDAYYDQSSQ FTD
Sbjct: 147 LPVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQLLKLKSSSGNFDAYYDQSSQDFTD 206
Query: 818 TEKEIISEWA 847
TEKEIISEWA
Sbjct: 207 TEKEIISEWA 216
Score = 183 bits (445), Expect = 6e-45
Identities = 87/87 (100%), Positives = 87/87 (100%)
Frame = +1
Query: 199 MLTAVDNLFTVSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIH 378
MLTAVDNLFTVSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIH
Sbjct: 1 MLTAVDNLFTVSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIH 60
Query: 379 LPCVDLQETIPLEPTVKSLFHPKLAPG 459
LPCVDLQETIPLEPTVKSLFHPKLAPG
Sbjct: 61 LPCVDLQETIPLEPTVKSLFHPKLAPG 87
>UniRef50_UPI00015B4200 Cluster: PREDICTED: similar to mevalonate
kinase; n=1; Nasonia vitripennis|Rep: PREDICTED: similar
to mevalonate kinase - Nasonia vitripennis
Length = 388
Score = 70.5 bits (165), Expect = 5e-11
Identities = 38/70 (54%), Positives = 49/70 (70%), Gaps = 1/70 (1%)
Frame = +1
Query: 235 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPA-VHIHLPCVDLQETIP 411
+SAPGKVIL GEHSVVYGKTA+A SLGLRSS+ E+ PHE +HI +P + + + +
Sbjct: 6 ISAPGKVILFGEHSVVYGKTAVAASLGLRSSLHFTEL--PHEECIIHIKMPKLGISKILS 63
Query: 412 LEPTVKSLFH 441
L V+ FH
Sbjct: 64 LH-QVEEDFH 72
Score = 51.2 bits (117), Expect = 3e-05
Identities = 28/91 (30%), Positives = 51/91 (56%)
Frame = +2
Query: 497 IDHDYHLRRVEEYLHLIKPNFDSLPNNQKNSLRSFLYVFSGIFGSTYLPVKSMDISMGSE 676
++HD +++++Y+ + F++ +Q+ S+ F Y + S L + S + + SE
Sbjct: 82 MNHDAINQKLQKYVATL--GFEN--PDQRLSMECFFYAMMQVIRSDQLRLSSFILELDSE 137
Query: 677 LTIGAGTGSSASFAVCLAGALIQLLKLKSSS 769
L+IGAG GSSASF VCL + +L+ +
Sbjct: 138 LSIGAGAGSSASFTVCLVACFLHWSQLQKGT 168
>UniRef50_UPI0000D56452 Cluster: PREDICTED: similar to mevalonate
kinase; n=3; Endopterygota|Rep: PREDICTED: similar to
mevalonate kinase - Tribolium castaneum
Length = 490
Score = 70.5 bits (165), Expect = 5e-11
Identities = 47/133 (35%), Positives = 72/133 (54%), Gaps = 5/133 (3%)
Frame = +2
Query: 464 TGKFSWRLPHKIDHDYHLRRVEEYLHLIKPNFDSLPNNQKNSLRSFLYVFSGIFGSTYLP 643
T ++ P +DHD VE+++ L + Q+ +L SF Y+F I GST
Sbjct: 172 TAYYNLTHPELLDHDKITEIVEKFVDLNRHE-----PKQRQALVSFFYLFFAIVGSTDSN 226
Query: 644 VKS-MDISMGSELTIGAGTGSSASFAVCLAGALIQLLKLKS-SSGNFDAYYD---QSSQX 808
+ +++ S+LT+GAGTGSSASFAV +A L+ +K+K S N D + Q
Sbjct: 227 LSDGFKLAVRSDLTVGAGTGSSASFAVAIAAFLLHFVKVKKFKSKNLYKSLDLNVDNLQN 286
Query: 809 FTDTEKEIISEWA 847
F TE +++S+WA
Sbjct: 287 FDTTELDLVSKWA 299
Score = 56.4 bits (130), Expect = 8e-07
Identities = 26/37 (70%), Positives = 30/37 (81%)
Frame = +1
Query: 220 LFTVSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSI 330
L + VSAPGKVILHGEHSVVY K A+A SLGLR+ +
Sbjct: 95 LSEIRVSAPGKVILHGEHSVVYDKLAVAASLGLRTRL 131
>UniRef50_UPI0000587FA1 Cluster: PREDICTED: similar to Mevalonate
kinase (MK); n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to Mevalonate kinase (MK) -
Strongylocentrotus purpuratus
Length = 413
Score = 65.7 bits (153), Expect = 1e-09
Identities = 29/60 (48%), Positives = 46/60 (76%)
Frame = +1
Query: 226 TVSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQET 405
++ +SAPGK+ILHGEH+VV+GKTA+A L LRS + +KE ++ +H++LP +DL+ +
Sbjct: 15 SIFISAPGKIILHGEHAVVHGKTALAAGLNLRSYLCLKEKDSGR---LHLNLPDIDLERS 71
Score = 41.1 bits (92), Expect = 0.034
Identities = 30/98 (30%), Positives = 48/98 (48%), Gaps = 1/98 (1%)
Frame = +2
Query: 557 FDSLPNNQKNSLRSFLYVFSGIFGST-YLPVKSMDISMGSELTIGAGTGSSASFAVCLAG 733
+ ++ ++ +FLY++ I G P+ +D + S L GAG GSSA+F+VCLA
Sbjct: 108 YSDTETTKRLAVMAFLYLYLCIAGRNGKFPI--LDTLVSSALPPGAGLGSSAAFSVCLAA 165
Query: 734 ALIQLLKLKSSSGNFDAYYDQSSQXFTDTEKEIISEWA 847
L+ K D D S + + E+I+ WA
Sbjct: 166 GLLTWAKAIIPLSLSDNTLDWSRE-----DMELINTWA 198
>UniRef50_A7SJK4 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 415
Score = 63.3 bits (147), Expect = 7e-09
Identities = 28/40 (70%), Positives = 36/40 (90%)
Frame = +1
Query: 220 LFTVSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIK 339
L V VSAPGK+ILHGEH+VVYGK AIAVS+GLR+++V++
Sbjct: 3 LSRVVVSAPGKIILHGEHAVVYGKAAIAVSIGLRTTVVLQ 42
Score = 34.3 bits (75), Expect = 3.9
Identities = 26/100 (26%), Positives = 53/100 (53%), Gaps = 11/100 (11%)
Frame = +2
Query: 581 KNSLRSFLYVF-SGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQLLK- 754
K++ R FL++ S + LP ++++ + + L +GAG GSSA++++ LA A++ ++
Sbjct: 110 KDAARVFLFLMTSTLRDRDRLP--AIEVEVKTALPLGAGLGSSAAYSISLAAAMLLSMQT 167
Query: 755 ------LKSSSGNFDAYYDQSSQXFTDTEKE---IISEWA 847
+K + + D S + D E E ++ +WA
Sbjct: 168 IPLPKYVKKTPESETTAKDTDSYQYDDIETESLRLVCQWA 207
>UniRef50_UPI0000E810F5 Cluster: PREDICTED: hypothetical protein;
n=1; Gallus gallus|Rep: PREDICTED: hypothetical protein
- Gallus gallus
Length = 527
Score = 56.8 bits (131), Expect = 6e-07
Identities = 29/55 (52%), Positives = 40/55 (72%)
Frame = +1
Query: 235 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQ 399
VSAPGKVILHGEH+VV+GK A+AV+LGLR+ + ++ + IHLP V ++
Sbjct: 181 VSAPGKVILHGEHAVVHGKAALAVALGLRTFLRLRPGGGER---LRIHLPGVGVR 232
Score = 50.4 bits (115), Expect = 6e-05
Identities = 31/87 (35%), Positives = 50/87 (57%)
Frame = +2
Query: 587 SLRSFLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQLLKLKSS 766
++ +FLY+ I + Y V S+DI++ SEL GAG GSSA++AVCLA AL+ + S
Sbjct: 312 AILAFLYMCLAI-SAKYGDVPSVDIAVWSELPTGAGLGSSAAYAVCLAAALLHACRAISC 370
Query: 767 SGNFDAYYDQSSQXFTDTEKEIISEWA 847
+++ + + E +I+ WA
Sbjct: 371 ----PLKDGEATARWPEEEMSLINSWA 393
>UniRef50_UPI000155619E Cluster: PREDICTED: hypothetical protein,
partial; n=1; Ornithorhynchus anatinus|Rep: PREDICTED:
hypothetical protein, partial - Ornithorhynchus anatinus
Length = 282
Score = 55.2 bits (127), Expect = 2e-06
Identities = 29/60 (48%), Positives = 40/60 (66%)
Frame = +1
Query: 226 TVSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQET 405
T+ VSAPGK ILHGEHSVV+GK A+AV+L LR+ + + + V + LP + L+ T
Sbjct: 5 TLVVSAPGKAILHGEHSVVHGKVALAVALNLRTFL---QFRPGDQDRVTVSLPNLGLRRT 61
Score = 51.6 bits (118), Expect = 2e-05
Identities = 36/120 (30%), Positives = 62/120 (51%)
Frame = +2
Query: 488 PHKIDHDYHLRRVEEYLHLIKPNFDSLPNNQKNSLRSFLYVFSGIFGSTYLPVKSMDISM 667
P + + +++E+ L DS Q +L +FLY+++ I G T +D+++
Sbjct: 144 PSAVPTPERMEKLKEFAGLAPGPLDS----QGLALLAFLYLYTAI-GGTDGAWPGVDVTV 198
Query: 668 GSELTIGAGTGSSASFAVCLAGALIQLLKLKSSSGNFDAYYDQSSQXFTDTEKEIISEWA 847
SEL G G GSSA+++ C A A + L S+ + D +S +T+ E E+I+ WA
Sbjct: 199 WSELPPGGGLGSSAAYSACSASAWLSALDTVSAPWDHDFL---ASGRWTEEELELINRWA 255
>UniRef50_A3LQ81 Cluster: Mevalonate kinase; n=5;
Saccharomycetales|Rep: Mevalonate kinase - Pichia
stipitis (Yeast)
Length = 432
Score = 55.2 bits (127), Expect = 2e-06
Identities = 33/92 (35%), Positives = 51/92 (55%), Gaps = 5/92 (5%)
Frame = +1
Query: 235 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDL-----Q 399
VSAPGKVI+ GEHS VYGK AIA +L LR+ +++ P +++ P ++L +
Sbjct: 7 VSAPGKVIIFGEHSAVYGKPAIAAALSLRAYLLVTPSQDP--DTINLSFPDINLTHSWNK 64
Query: 400 ETIPLEPTVKSLFHPKLAPGXNRQILLEITPQ 495
IP + VK + P + +++ EI Q
Sbjct: 65 NDIPWDSIVKHINLVDNLPQTSEELVPEIVDQ 96
Score = 38.7 bits (86), Expect = 0.18
Identities = 25/60 (41%), Positives = 35/60 (58%)
Frame = +2
Query: 599 FLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQLLKLKSSSGNF 778
FLY+++ + + M + S L IGAG GSSAS AVCLA AL +L + +S +F
Sbjct: 116 FLYLYTHLCNQE---LAGMSFCIRSTLPIGAGLGSSASTAVCLASAL-AILGNRVTSASF 171
>UniRef50_Q65XX9 Cluster: Putative uncharacterized protein; n=5;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 614
Score = 54.8 bits (126), Expect = 3e-06
Identities = 28/66 (42%), Positives = 46/66 (69%)
Frame = +1
Query: 235 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQETIPL 414
VSAPGK+IL GEH+VVYG+TAIA S+ LR+ + + T + +++ LP + +++T L
Sbjct: 144 VSAPGKIILFGEHAVVYGRTAIAGSIDLRTYV---SLYTSADGRIYLSLPDLGVEKTWML 200
Query: 415 EPTVKS 432
+ +K+
Sbjct: 201 KDLLKA 206
>UniRef50_Q03426 Cluster: Mevalonate kinase; n=26; Euteleostomi|Rep:
Mevalonate kinase - Homo sapiens (Human)
Length = 396
Score = 54.4 bits (125), Expect = 3e-06
Identities = 29/56 (51%), Positives = 40/56 (71%), Gaps = 1/56 (1%)
Frame = +1
Query: 235 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPA-VHIHLPCVDLQ 399
VSAPGKVILHGEH+VV+GK A+AVSL LR+ + ++ PH V + LP + ++
Sbjct: 8 VSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQ----PHSNGKVDLSLPNIGIK 59
Score = 44.0 bits (99), Expect = 0.005
Identities = 30/97 (30%), Positives = 54/97 (55%), Gaps = 1/97 (1%)
Frame = +2
Query: 560 DSLPNNQKNSLRSFLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGAL 739
D ++ ++ +FLY++ I + S+DI + SEL GAG GSSA+++VCLA AL
Sbjct: 99 DDCAVTERLAVLAFLYLYLSICRKQRA-LPSLDIVVWSELPPGAGLGSSAAYSVCLAAAL 157
Query: 740 IQLL-KLKSSSGNFDAYYDQSSQXFTDTEKEIISEWA 847
+ + ++ + + D +T + E+I++WA
Sbjct: 158 LTVCEEIPNPLKDGDCV-----NRWTKEDLELINKWA 189
>UniRef50_Q6CEF6 Cluster: Yarrowia lipolytica chromosome B of strain
CLIB122 of Yarrowia lipolytica; n=1; Yarrowia
lipolytica|Rep: Yarrowia lipolytica chromosome B of
strain CLIB122 of Yarrowia lipolytica - Yarrowia
lipolytica (Candida lipolytica)
Length = 449
Score = 53.6 bits (123), Expect = 6e-06
Identities = 25/61 (40%), Positives = 39/61 (63%)
Frame = +1
Query: 235 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQETIPL 414
+SAPGKVIL GEH+ V+GK AIA ++ LR+ +++ E T P V + P + L + +
Sbjct: 5 ISAPGKVILFGEHAAVFGKPAIAAAIDLRTYLLV-ETTTSDTPTVTLEFPDIHLNFKVQV 63
Query: 415 E 417
+
Sbjct: 64 D 64
Score = 38.7 bits (86), Expect = 0.18
Identities = 33/124 (26%), Positives = 57/124 (45%)
Frame = +2
Query: 476 SWRLPHKIDHDYHLRRVEEYLHLIKPNFDSLPNNQKNSLRSFLYVFSGIFGSTYLPVKSM 655
+W P +D H+ L L++ L Q+ ++ SFLY++ + + S
Sbjct: 79 NWSTPKTLDK--HIFDSLSSLALLEE--PGLTKVQQAAVVSFLYLYIHLCPPSVCEDSSN 134
Query: 656 DISMGSELTIGAGTGSSASFAVCLAGALIQLLKLKSSSGNFDAYYDQSSQXFTDTEKEII 835
+ + S L IGAG GSSAS VCLA L+ L +G + + T+ + ++
Sbjct: 135 WV-VRSTLPIGAGLGSSASICVCLAAGLLVL------NGQLSIDQARDFKSLTEKQLSLV 187
Query: 836 SEWA 847
+W+
Sbjct: 188 DDWS 191
>UniRef50_UPI0000DB6B27 Cluster: PREDICTED: similar to Mevalonate
kinase (MK); n=1; Apis mellifera|Rep: PREDICTED: similar
to Mevalonate kinase (MK) - Apis mellifera
Length = 359
Score = 52.4 bits (120), Expect = 1e-05
Identities = 24/37 (64%), Positives = 30/37 (81%)
Frame = +1
Query: 235 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEV 345
VSAPGKVIL GEH+VVYGKTA+A S+ LR+ + E+
Sbjct: 6 VSAPGKVILFGEHAVVYGKTAVAASIDLRTVLNFTEL 42
Score = 49.2 bits (112), Expect = 1e-04
Identities = 25/63 (39%), Positives = 34/63 (53%)
Frame = +2
Query: 578 QKNSLRSFLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQLLKL 757
QK SL +F Y I + +K I + +EL I +G GSSASFAVCLA + L
Sbjct: 81 QKLSLEAFFYTLIYIAQKEEMEIKPFQIQLNTELAINSGLGSSASFAVCLAACFVHWSHL 140
Query: 758 KSS 766
+ +
Sbjct: 141 QKN 143
>UniRef50_Q7PWI8 Cluster: ENSANGP00000021364; n=2; Culicidae|Rep:
ENSANGP00000021364 - Anopheles gambiae str. PEST
Length = 402
Score = 51.6 bits (118), Expect = 2e-05
Identities = 24/30 (80%), Positives = 26/30 (86%)
Frame = +1
Query: 235 VSAPGKVILHGEHSVVYGKTAIAVSLGLRS 324
VSAPGKVILHGEHSVVYG AIA S+GL +
Sbjct: 11 VSAPGKVILHGEHSVVYGHPAIAGSIGLHT 40
Score = 40.7 bits (91), Expect = 0.045
Identities = 18/33 (54%), Positives = 25/33 (75%)
Frame = +2
Query: 659 ISMGSELTIGAGTGSSASFAVCLAGALIQLLKL 757
+S+ SE++IGAG GSSAS+ VCLA QL ++
Sbjct: 143 LSLYSEMSIGAGLGSSASYGVCLAAGAYQLSRI 175
>UniRef50_Q0UWF5 Cluster: Putative uncharacterized protein; n=1;
Phaeosphaeria nodorum|Rep: Putative uncharacterized
protein - Phaeosphaeria nodorum (Septoria nodorum)
Length = 526
Score = 51.6 bits (118), Expect = 2e-05
Identities = 24/57 (42%), Positives = 39/57 (68%)
Frame = +1
Query: 235 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQET 405
VSAPGKVI++GEH+VV+GK AIA ++ LRS + + ++ + V + P + ++ T
Sbjct: 37 VSAPGKVIVYGEHAVVHGKAAIAAAISLRSYLHVSFLSKSNR-TVKLRFPDIQMEHT 92
Score = 41.9 bits (94), Expect = 0.019
Identities = 36/127 (28%), Positives = 64/127 (50%), Gaps = 1/127 (0%)
Frame = +2
Query: 470 KFSWRLPHKIDHDYHLRRVEEYLHLIKPNF-DSLPNNQKNSLRSFLYVFSGIFGSTYLPV 646
K+ + L +D D + ++ ++ + P +S+ S SFLY+F + P
Sbjct: 110 KYYYDLVTSLDPDL-MAAIQPFIDEVSPKAPESVRKIHHASACSFLYLFLSLASRKTPPC 168
Query: 647 KSMDISMGSELTIGAGTGSSASFAVCLAGALIQLLKLKSSSGNFDAYYDQSSQXFTDTEK 826
++ S + IGAG GSSAS +VCL+ A+ L+++++ SG + DQ Q +
Sbjct: 169 I---YTLRSTIPIGAGLGSSASISVCLSAAM--LMQIRALSG---PHQDQPPQE-CELNI 219
Query: 827 EIISEWA 847
E I+ W+
Sbjct: 220 ERINRWS 226
>UniRef50_Q4WP25 Cluster: Mevalonate kinase; n=15;
Pezizomycotina|Rep: Mevalonate kinase - Aspergillus
fumigatus (Sartorya fumigata)
Length = 538
Score = 50.0 bits (114), Expect = 7e-05
Identities = 24/69 (34%), Positives = 44/69 (63%)
Frame = +1
Query: 235 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQETIPL 414
VSAPGKVI++GEH+VV+GK A+A ++ LRS +++ + + + + ++ + L T +
Sbjct: 94 VSAPGKVIVYGEHAVVHGKAAMAAAISLRSYLLVTTL-SKSQRTITMNFRDIGLDHTWNI 152
Query: 415 EPTVKSLFH 441
+ +FH
Sbjct: 153 DELPWDVFH 161
Score = 43.6 bits (98), Expect = 0.006
Identities = 38/134 (28%), Positives = 68/134 (50%), Gaps = 1/134 (0%)
Frame = +2
Query: 449 WHQGITGKFSWRLPHKIDHDYHLRRVEEYLHLIKPNF-DSLPNNQKNSLRSFLYVFSGIF 625
+H KF + L +D + + ++ + + P+ + + + S +FLY+F +
Sbjct: 160 FHHPSKKKFYYDLVTSLDPEL-VAAIQPHADAVSPDKPEDVRKIHRRSASAFLYLFLSL- 217
Query: 626 GSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQLLKLKSSSGNFDAYYDQSSQ 805
GS+ P ++ S + IGAG GSSAS VCL+ AL LL++++ +G + DQ
Sbjct: 218 GSSQNP--GAIYTLRSTIPIGAGLGSSASVCVCLSAAL--LLQIRTLAG---PHPDQPPD 270
Query: 806 XFTDTEKEIISEWA 847
+ + E I+ WA
Sbjct: 271 E-AEVQIERINRWA 283
>UniRef50_Q86AG7 Cluster: Similar to Rattus norvegicus (Rat).
Mevalonate kinase; n=2; Dictyostelium discoideum|Rep:
Similar to Rattus norvegicus (Rat). Mevalonate kinase -
Dictyostelium discoideum (Slime mold)
Length = 390
Score = 49.2 bits (112), Expect = 1e-04
Identities = 24/44 (54%), Positives = 34/44 (77%)
Frame = +1
Query: 199 MLTAVDNLFTVSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSI 330
M++ DN+ + VSAPGK+IL GEH+VV KTAIA +L LR+++
Sbjct: 1 MISNQDNI--IQVSAPGKIILFGEHAVVLEKTAIASALSLRTTV 42
Score = 37.9 bits (84), Expect = 0.32
Identities = 20/52 (38%), Positives = 32/52 (61%)
Frame = +2
Query: 590 LRSFLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQ 745
+ +FL++F + T K+ +I + S+L IGAG GSSASF V + L++
Sbjct: 107 IHTFLFLFCALTKCT----KAYNIKITSDLPIGAGLGSSASFCVSICAGLLK 154
>UniRef50_Q4TG59 Cluster: Chromosome undetermined SCAF3891, whole
genome shotgun sequence; n=2; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF3891,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 173
Score = 48.8 bits (111), Expect = 2e-04
Identities = 29/62 (46%), Positives = 40/62 (64%), Gaps = 7/62 (11%)
Frame = +1
Query: 229 VSVSAPGKVILHGEHSVVYGKT-------AIAVSLGLRSSIVIKEVNTPHEPAVHIHLPC 387
+ VSAPGK ILHGEH+VV+GK A+AVSL LRS + ++ +T V ++LP
Sbjct: 1 IYVSAPGKAILHGEHAVVHGKVTSNKAKMALAVSLNLRSYLRLEATST---GTVGVNLPN 57
Query: 388 VD 393
+D
Sbjct: 58 ID 59
Score = 44.0 bits (99), Expect = 0.005
Identities = 26/64 (40%), Positives = 36/64 (56%)
Frame = +2
Query: 551 PNFDSLPNNQKNSLRSFLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLA 730
PN D+ + + L+ F SG T L + +S+ SEL GAG GSSA++ VCLA
Sbjct: 56 PNIDTFLHWNLSELKQFAPSVSGNEQLT-LGAAQLTVSVWSELPTGAGLGSSAAYTVCLA 114
Query: 731 GALI 742
AL+
Sbjct: 115 AALL 118
>UniRef50_A2SR97 Cluster: Mevalonate kinase; n=4;
Methanomicrobiales|Rep: Mevalonate kinase -
Methanocorpusculum labreanum (strain ATCC 43576 / DSM
4855 / Z)
Length = 290
Score = 47.6 bits (108), Expect = 4e-04
Identities = 22/42 (52%), Positives = 29/42 (69%)
Frame = +1
Query: 238 SAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEP 363
SAPGKVIL GEHSVVYGK AIA+++ R + ++ +P
Sbjct: 5 SAPGKVILFGEHSVVYGKPAIAMAIKPRVQVTVRHSRYYQKP 46
>UniRef50_Q09780 Cluster: Putative mevalonate kinase; n=1;
Schizosaccharomyces pombe|Rep: Putative mevalonate
kinase - Schizosaccharomyces pombe (Fission yeast)
Length = 404
Score = 47.2 bits (107), Expect = 5e-04
Identities = 21/38 (55%), Positives = 28/38 (73%)
Frame = +1
Query: 235 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVN 348
VS+PGK IL GEH+VVYG TA+A ++ LRS ++ N
Sbjct: 7 VSSPGKTILFGEHAVVYGATALAAAVSLRSYCKLQTTN 44
Score = 35.1 bits (77), Expect = 2.2
Identities = 19/69 (27%), Positives = 38/69 (55%)
Frame = +2
Query: 536 LHLIKPNFDSLPNNQKNSLRSFLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASF 715
L L++ + L N + + S + +F S P + +++ S++ +GAG GSSA+
Sbjct: 85 LDLLQGLGELLKNEENGLIHSAMLCTLYLFTSLSSPSQGCTLTISSQVPLGAGLGSSATI 144
Query: 716 AVCLAGALI 742
+V +A +L+
Sbjct: 145 SVVVATSLL 153
>UniRef50_Q8TT37 Cluster: Mevalonate kinase; n=5; Euryarchaeota|Rep:
Mevalonate kinase - Methanosarcina acetivorans
Length = 305
Score = 46.4 bits (105), Expect = 0.001
Identities = 19/37 (51%), Positives = 29/37 (78%)
Frame = +1
Query: 229 VSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIK 339
+S SAPGK+ L GEH+VVYG+TAI ++ LR+ + ++
Sbjct: 6 ISCSAPGKIYLFGEHAVVYGETAIGCAIELRTRVRVE 42
>UniRef50_P07277 Cluster: Mevalonate kinase; n=3;
Saccharomycetales|Rep: Mevalonate kinase - Saccharomyces
cerevisiae (Baker's yeast)
Length = 443
Score = 46.0 bits (104), Expect = 0.001
Identities = 22/40 (55%), Positives = 29/40 (72%), Gaps = 1/40 (2%)
Frame = +1
Query: 238 SAPGKVILHGEHSVVYGKTAIAVSL-GLRSSIVIKEVNTP 354
SAPGKVI+ GEHS VY K A+A S+ LR+ ++I E + P
Sbjct: 8 SAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAP 47
Score = 36.3 bits (80), Expect = 0.97
Identities = 24/67 (35%), Positives = 37/67 (55%)
Frame = +2
Query: 647 KSMDISMGSELTIGAGTGSSASFAVCLAGALIQLLKLKSSSGNFDAYYDQSSQXFTDTEK 826
K++ S+ S L IGAG GSSAS +V LA A+ L L S+ + ++ +K
Sbjct: 130 KNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSN---------DLEKLSENDK 180
Query: 827 EIISEWA 847
I+++WA
Sbjct: 181 HIVNQWA 187
>UniRef50_Q50559 Cluster: Mevalonate kinase; n=2;
Methanothermobacter thermautotrophicus str. Delta H|Rep:
Mevalonate kinase - Methanobacterium thermoautotrophicum
Length = 303
Score = 46.0 bits (104), Expect = 0.001
Identities = 20/42 (47%), Positives = 28/42 (66%)
Frame = +1
Query: 232 SVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPH 357
S SAP K IL GEH+VVY K AIA ++ R ++ + E ++ H
Sbjct: 4 SASAPAKAILFGEHAVVYSKPAIAAAIDRRVTVTVSESSSTH 45
>UniRef50_Q0LHN3 Cluster: Mevalonate kinase; n=2; Chloroflexi
(class)|Rep: Mevalonate kinase - Herpetosiphon
aurantiacus ATCC 23779
Length = 313
Score = 45.6 bits (103), Expect = 0.002
Identities = 23/54 (42%), Positives = 36/54 (66%), Gaps = 1/54 (1%)
Frame = +1
Query: 238 SAPGKVILHGEHSVVYGKTAIAVSL-GLRSSIVIKEVNTPHEPAVHIHLPCVDL 396
SAPGK+IL GEH+VVYG+ A+A+ + LR+S+ ++ P + +H P + L
Sbjct: 3 SAPGKLILAGEHAVVYGQPALAMPIAALRASVAVEP--APRGAGMTVHAPDLGL 54
>UniRef50_A0B6E3 Cluster: Mevalonate kinase; n=1; Methanosaeta
thermophila PT|Rep: Mevalonate kinase - Methanosaeta
thermophila (strain DSM 6194 / PT)
(Methanothrixthermophila (strain DSM 6194 / PT))
Length = 321
Score = 45.6 bits (103), Expect = 0.002
Identities = 19/47 (40%), Positives = 33/47 (70%)
Frame = +1
Query: 232 SVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVH 372
+ SAPGKVIL GEH+VV G A+ ++ LR+ ++++++ E ++H
Sbjct: 3 AASAPGKVILFGEHAVVSGAPALGTAIDLRARVLVEDLPGKTEISIH 49
>UniRef50_Q9V187 Cluster: Mevalonate kinase; n=4;
Thermococcaceae|Rep: Mevalonate kinase - Pyrococcus
abyssi
Length = 335
Score = 45.6 bits (103), Expect = 0.002
Identities = 21/34 (61%), Positives = 26/34 (76%)
Frame = +1
Query: 229 VSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSI 330
V SAP K+IL GEHSVVYGK AIA ++ LR+ +
Sbjct: 5 VLASAPAKIILFGEHSVVYGKPAIASAIDLRTYV 38
Score = 36.3 bits (80), Expect = 0.97
Identities = 17/38 (44%), Positives = 27/38 (71%)
Frame = +2
Query: 653 MDISMGSELTIGAGTGSSASFAVCLAGALIQLLKLKSS 766
+ +S+ S++ +GAG GSSA+ AV GA+ +LL L+ S
Sbjct: 102 VSVSITSQIPVGAGLGSSAAVAVATIGAVSKLLDLELS 139
>UniRef50_Q58487 Cluster: Mevalonate kinase; n=1; Methanocaldococcus
jannaschii|Rep: Mevalonate kinase - Methanococcus
jannaschii
Length = 312
Score = 44.4 bits (100), Expect = 0.004
Identities = 20/36 (55%), Positives = 27/36 (75%)
Frame = +1
Query: 235 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKE 342
+ P KVIL GEH+VVYG AI++++ L S+I IKE
Sbjct: 3 IETPSKVILFGEHAVVYGYRAISMAIDLTSTIEIKE 38
>UniRef50_Q7K2V9 Cluster: GH04687p; n=1; Drosophila
melanogaster|Rep: GH04687p - Drosophila melanogaster
(Fruit fly)
Length = 390
Score = 44.0 bits (99), Expect = 0.005
Identities = 18/37 (48%), Positives = 29/37 (78%)
Frame = +1
Query: 235 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEV 345
V +PGKVILHGEH+VVY + A+A +GL +++ +++
Sbjct: 6 VHSPGKVILHGEHAVVYHRPALAAVVGLGTTLRFRQL 42
Score = 35.9 bits (79), Expect = 1.3
Identities = 22/63 (34%), Positives = 33/63 (52%)
Frame = +2
Query: 659 ISMGSELTIGAGTGSSASFAVCLAGALIQLLKLKSSSGNFDAYYDQSSQXFTDTEKEIIS 838
+ + S+LT+GAG GSSASF LA + L +G+FD ++ + +IS
Sbjct: 141 VQVDSQLTVGAGLGSSASFGAALATTFLIL------AGHFD-----RDSYLSEANQALIS 189
Query: 839 EWA 847
WA
Sbjct: 190 SWA 192
>UniRef50_Q756D2 Cluster: AER335Wp; n=3; Saccharomycetaceae|Rep:
AER335Wp - Ashbya gossypii (Yeast) (Eremothecium
gossypii)
Length = 428
Score = 44.0 bits (99), Expect = 0.005
Identities = 23/54 (42%), Positives = 31/54 (57%)
Frame = +1
Query: 238 SAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQ 399
SAPGKVI+ GEHS VY K AIA S+ + + E + + AV + P + Q
Sbjct: 19 SAPGKVIIFGEHSAVYNKPAIAASVSSLRTYLFVEADAESD-AVRMEFPDIGFQ 71
Score = 37.5 bits (83), Expect = 0.42
Identities = 26/83 (31%), Positives = 41/83 (49%)
Frame = +2
Query: 599 FLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQLLKLKSSSGNF 778
FLY+++ + V+ + ++ S L IGAG GSSAS AVCLA A+ G
Sbjct: 123 FLYIYTCLCRE----VQGVRFTVKSTLPIGAGLGSSASIAVCLALAM----------GRL 168
Query: 779 DAYYDQSSQXFTDTEKEIISEWA 847
+ S T +++ ++ WA
Sbjct: 169 GGHVQCESGALTKEQQDFVNRWA 191
>UniRef50_O27995 Cluster: Mevalonate kinase; n=1; Archaeoglobus
fulgidus|Rep: Mevalonate kinase - Archaeoglobus fulgidus
Length = 284
Score = 44.0 bits (99), Expect = 0.005
Identities = 17/35 (48%), Positives = 27/35 (77%)
Frame = +1
Query: 238 SAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKE 342
SAPGK+IL GEH+VVYG+ A+ ++ LR + +++
Sbjct: 4 SAPGKIILFGEHAVVYGRHAVVSAINLRCRVSVRK 38
>UniRef50_UPI000155611C Cluster: PREDICTED: hypothetical protein,
partial; n=1; Ornithorhynchus anatinus|Rep: PREDICTED:
hypothetical protein, partial - Ornithorhynchus anatinus
Length = 269
Score = 43.6 bits (98), Expect = 0.006
Identities = 27/85 (31%), Positives = 46/85 (54%)
Frame = +2
Query: 488 PHKIDHDYHLRRVEEYLHLIKPNFDSLPNNQKNSLRSFLYVFSGIFGSTYLPVKSMDISM 667
P + + +++E+ L DS Q +L +FLY+++ I G T +D+++
Sbjct: 68 PSAVPTPEQMEKLKEFAGLAPGPLDS----QGLALLAFLYLYTAI-GGTDGAWPGVDVTV 122
Query: 668 GSELTIGAGTGSSASFAVCLAGALI 742
SEL G G GSSA+++ CLA L+
Sbjct: 123 WSELPPGGGLGSSAAYSACLAACLL 147
>UniRef50_Q9HQI6 Cluster: Mevalonate kinase; n=5;
Halobacteriaceae|Rep: Mevalonate kinase - Halobacterium
salinarium (Halobacterium halobium)
Length = 330
Score = 43.2 bits (97), Expect = 0.008
Identities = 18/39 (46%), Positives = 27/39 (69%)
Frame = +1
Query: 226 TVSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKE 342
T + SAPGKV L GEH+VVYG+ A+ ++ R+ + + E
Sbjct: 2 TTTSSAPGKVYLFGEHAVVYGEPAVPCAIERRAHVTVSE 40
>UniRef50_Q2HTL9 Cluster: Mevalonate and galactokinase; n=5; core
eudicotyledons|Rep: Mevalonate and galactokinase -
Medicago truncatula (Barrel medic)
Length = 388
Score = 42.7 bits (96), Expect = 0.011
Identities = 20/42 (47%), Positives = 30/42 (71%)
Frame = +1
Query: 229 VSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTP 354
V APGK+IL GEH+VV+G TA+A S+ L + + ++ +TP
Sbjct: 3 VKARAPGKIILAGEHAVVHGSTAVASSIDLYTYVSLR-FSTP 43
Score = 40.3 bits (90), Expect = 0.059
Identities = 26/88 (29%), Positives = 48/88 (54%)
Frame = +2
Query: 584 NSLRSFLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQLLKLKS 763
+ + +FL+++S I G K + + S+L +G+G GSSA+F V LA A + + +
Sbjct: 113 SGVAAFLWLYSSIQG-----FKPATVVINSDLPLGSGLGSSAAFCVALAAAFLAV----T 163
Query: 764 SSGNFDAYYDQSSQXFTDTEKEIISEWA 847
S + D Q F + E +++++WA
Sbjct: 164 DSVSVDV-IRQGWHSFGEKELDLVNKWA 190
>UniRef50_A1RYL2 Cluster: Mevalonate kinase; n=1; Thermofilum
pendens Hrk 5|Rep: Mevalonate kinase - Thermofilum
pendens (strain Hrk 5)
Length = 322
Score = 42.7 bits (96), Expect = 0.011
Identities = 19/38 (50%), Positives = 27/38 (71%)
Frame = +1
Query: 238 SAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNT 351
SAP KVIL GEH VV G+ AIA ++ LR+ + ++ +T
Sbjct: 7 SAPAKVILFGEHFVVEGQPAIAAAISLRAHVTVEPADT 44
>UniRef50_P46086 Cluster: Mevalonate kinase; n=8; Magnoliophyta|Rep:
Mevalonate kinase - Arabidopsis thaliana (Mouse-ear
cress)
Length = 378
Score = 42.7 bits (96), Expect = 0.011
Identities = 17/37 (45%), Positives = 27/37 (72%)
Frame = +1
Query: 229 VSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIK 339
V APGK+IL GEH+VV+G TA+A ++ L + + ++
Sbjct: 3 VKARAPGKIILAGEHAVVHGSTAVAAAIDLYTYVTLR 39
Score = 34.7 bits (76), Expect = 3.0
Identities = 25/88 (28%), Positives = 46/88 (52%)
Frame = +2
Query: 584 NSLRSFLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQLLKLKS 763
+ + +FL++++ I G + P + + SEL G+G GSSA+ V L AL+ +
Sbjct: 114 SGISTFLWLYTRIIG--FNPAT---VVINSELPYGSGLGSSAALCVALTAALLASSISEK 168
Query: 764 SSGNFDAYYDQSSQXFTDTEKEIISEWA 847
+ GN + D +T E++++WA
Sbjct: 169 TRGNGWSSLD-------ETNLELLNKWA 189
>UniRef50_A5UV63 Cluster: Mevalonate kinase; n=3;
Chloroflexaceae|Rep: Mevalonate kinase - Roseiflexus sp.
RS-1
Length = 314
Score = 41.9 bits (94), Expect = 0.019
Identities = 18/25 (72%), Positives = 22/25 (88%)
Frame = +1
Query: 238 SAPGKVILHGEHSVVYGKTAIAVSL 312
SAPGK+IL GEH+VVYG+ AIA+ L
Sbjct: 4 SAPGKIILCGEHAVVYGRPAIAIPL 28
>UniRef50_A2E1U7 Cluster: Mevalonate kinase family protein; n=1;
Trichomonas vaginalis G3|Rep: Mevalonate kinase family
protein - Trichomonas vaginalis G3
Length = 315
Score = 40.7 bits (91), Expect = 0.045
Identities = 18/30 (60%), Positives = 23/30 (76%)
Frame = +1
Query: 232 SVSAPGKVILHGEHSVVYGKTAIAVSLGLR 321
S S PGKVIL GEH+VVYG+ A+A ++ R
Sbjct: 5 SFSFPGKVILFGEHAVVYGEAAVASAISRR 34
>UniRef50_A7DRD8 Cluster: Mevalonate kinase; n=1; Candidatus
Nitrosopumilus maritimus SCM1|Rep: Mevalonate kinase -
Candidatus Nitrosopumilus maritimus SCM1
Length = 313
Score = 40.7 bits (91), Expect = 0.045
Identities = 18/37 (48%), Positives = 26/37 (70%)
Frame = +1
Query: 238 SAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVN 348
SAPGKVIL GEH VVYG AI ++ R ++ ++++
Sbjct: 6 SAPGKVILFGEHFVVYGVKAILCAINKRIAVTAEKID 42
>UniRef50_UPI00015BB033 Cluster: mevalonate kinase; n=1; Ignicoccus
hospitalis KIN4/I|Rep: mevalonate kinase - Ignicoccus
hospitalis KIN4/I
Length = 321
Score = 39.9 bits (89), Expect = 0.079
Identities = 19/29 (65%), Positives = 21/29 (72%)
Frame = +1
Query: 226 TVSVSAPGKVILHGEHSVVYGKTAIAVSL 312
+VS AP KV L GEHSVVYGK AI S+
Sbjct: 2 SVSARAPTKVTLFGEHSVVYGKPAIVFSM 30
>UniRef50_A3HYY0 Cluster: Galactokinase; n=1; Algoriphagus sp.
PR1|Rep: Galactokinase - Algoriphagus sp. PR1
Length = 382
Score = 39.9 bits (89), Expect = 0.079
Identities = 20/69 (28%), Positives = 33/69 (47%)
Frame = +2
Query: 641 PVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQLLKLKSSSGNFDAYYDQSSQXFTDT 820
PVK DI G ++ +G+G SSA+ +V + A+ + K S + Y +S F
Sbjct: 103 PVKGFDIVFGGDIPVGSGLSSSAALSVAIGTAISAVFDFKISKKSIAIYAQKSEHLFEGL 162
Query: 821 EKEIISEWA 847
I+ +A
Sbjct: 163 NCGIMDPYA 171
>UniRef50_Q2NG06 Cluster: Putative mevalonate kinase; n=1;
Methanosphaera stadtmanae DSM 3091|Rep: Putative
mevalonate kinase - Methanosphaera stadtmanae (strain
DSM 3091)
Length = 322
Score = 39.9 bits (89), Expect = 0.079
Identities = 17/28 (60%), Positives = 22/28 (78%)
Frame = +1
Query: 229 VSVSAPGKVILHGEHSVVYGKTAIAVSL 312
+ APGK+IL GEH+VVY K AIAV++
Sbjct: 3 IKAFAPGKIILFGEHTVVYKKPAIAVAI 30
>UniRef50_A5UN66 Cluster: Mevalonate kinase; n=1; Methanobrevibacter
smithii ATCC 35061|Rep: Mevalonate kinase -
Methanobrevibacter smithii (strain PS / ATCC 35061 / DSM
861)
Length = 320
Score = 39.9 bits (89), Expect = 0.079
Identities = 20/38 (52%), Positives = 25/38 (65%)
Frame = +1
Query: 238 SAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNT 351
SAP K IL GEHSVVY + AIA ++ R+ + I E T
Sbjct: 6 SAPAKTILFGEHSVVYDEPAIAGAVNKRAYVEITESKT 43
>UniRef50_A3H636 Cluster: Mevalonate kinase; n=1; Caldivirga
maquilingensis IC-167|Rep: Mevalonate kinase -
Caldivirga maquilingensis IC-167
Length = 334
Score = 39.9 bits (89), Expect = 0.079
Identities = 17/38 (44%), Positives = 27/38 (71%)
Frame = +1
Query: 229 VSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKE 342
V+ +APG V L GEH+VVYG+ AIA+++ + ++E
Sbjct: 6 VTATAPGVVKLFGEHAVVYGRPAIAMAINKGIKVTVEE 43
>UniRef50_Q74JA4 Cluster: Mevalonate kinase; n=7; Lactobacillus|Rep:
Mevalonate kinase - Lactobacillus johnsonii
Length = 305
Score = 39.5 bits (88), Expect = 0.10
Identities = 20/43 (46%), Positives = 28/43 (65%), Gaps = 1/43 (2%)
Frame = +1
Query: 229 VSVSAPGKVILHGEHSVVYGKTAIAVSL-GLRSSIVIKEVNTP 354
+ V A GKVIL GEHSVVYG A+A+ + L + ++E + P
Sbjct: 5 IEVKAHGKVILIGEHSVVYGYDALALPIQALNITTTVEETDGP 47
>UniRef50_Q2BIK0 Cluster: Mevalonate kinase, putative; n=1;
Neptuniibacter caesariensis|Rep: Mevalonate kinase,
putative - Neptuniibacter caesariensis
Length = 327
Score = 39.5 bits (88), Expect = 0.10
Identities = 17/33 (51%), Positives = 24/33 (72%)
Frame = +1
Query: 229 VSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSS 327
+ APGK+IL GEHSVVYG AIA ++ +++
Sbjct: 1 MKAQAPGKLILSGEHSVVYGAPAIATAVAQQAT 33
>UniRef50_Q8TWN9 Cluster: Mevalonate kinase; n=1; Methanopyrus
kandleri|Rep: Mevalonate kinase - Methanopyrus kandleri
Length = 328
Score = 39.1 bits (87), Expect = 0.14
Identities = 18/28 (64%), Positives = 22/28 (78%)
Frame = +1
Query: 229 VSVSAPGKVILHGEHSVVYGKTAIAVSL 312
+SV AP K IL GEH+VVYG A+AV+L
Sbjct: 3 ISVKAPLKAILAGEHAVVYGYPAVAVAL 30
>UniRef50_Q6GN90 Cluster: MGC82947 protein; n=10; Euteleostomi|Rep:
MGC82947 protein - Xenopus laevis (African clawed frog)
Length = 90
Score = 38.7 bits (86), Expect = 0.18
Identities = 16/25 (64%), Positives = 18/25 (72%)
Frame = +3
Query: 9 CFKEELKTIHAFTQKTLTVDQWKTQ 83
C EELK IHAF QKTLT QW+ +
Sbjct: 63 CLAEELKVIHAFEQKTLTPAQWEQE 87
>UniRef50_A2BL67 Cluster: Mevalonate kinase; n=1; Hyperthermus
butylicus DSM 5456|Rep: Mevalonate kinase - Hyperthermus
butylicus (strain DSM 5456 / JCM 9403)
Length = 316
Score = 38.7 bits (86), Expect = 0.18
Identities = 17/29 (58%), Positives = 23/29 (79%)
Frame = +1
Query: 238 SAPGKVILHGEHSVVYGKTAIAVSLGLRS 324
SAP KVI+ GEH VV+G A+A ++GLR+
Sbjct: 6 SAPAKVIVFGEHWVVHGGLALAAAIGLRA 34
>UniRef50_Q9Y946 Cluster: Mevalonate kinase; n=1; Aeropyrum
pernix|Rep: Mevalonate kinase - Aeropyrum pernix
Length = 324
Score = 38.7 bits (86), Expect = 0.18
Identities = 17/34 (50%), Positives = 23/34 (67%)
Frame = +1
Query: 238 SAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIK 339
SAPGKVI+ GEH VV G AI ++G R + ++
Sbjct: 8 SAPGKVIIVGEHFVVRGSLAIVAAIGRRLRVTVR 41
>UniRef50_Q8L1I1 Cluster: Phosphomevalonate kinase; n=1; Paracoccus
zeaxanthinifaciens|Rep: Phosphomevalonate kinase -
Paracoccus zeaxanthinifaciens
Length = 305
Score = 38.3 bits (85), Expect = 0.24
Identities = 16/36 (44%), Positives = 23/36 (63%)
Frame = +1
Query: 229 VSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVI 336
+ SAPG V++ GEH+VVYG AI + R+ + I
Sbjct: 5 IRASAPGSVMITGEHAVVYGHRAIVAGIEQRAHVTI 40
>UniRef50_A6G140 Cluster: Hydroxymethylglutaryl-CoA reductase; n=1;
Plesiocystis pacifica SIR-1|Rep:
Hydroxymethylglutaryl-CoA reductase - Plesiocystis
pacifica SIR-1
Length = 810
Score = 38.3 bits (85), Expect = 0.24
Identities = 16/34 (47%), Positives = 26/34 (76%)
Frame = +1
Query: 223 FTVSVSAPGKVILHGEHSVVYGKTAIAVSLGLRS 324
+T +VSAPGK L GE++V+YG +AI ++ +R+
Sbjct: 43 YTGTVSAPGKAFLIGEYAVLYGHSAIVTAVDVRA 76
>UniRef50_Q9H3K6 Cluster: BolA-like protein 2; n=18;
Deuterostomia|Rep: BolA-like protein 2 - Homo sapiens
(Human)
Length = 86
Score = 37.9 bits (84), Expect = 0.32
Identities = 16/22 (72%), Positives = 16/22 (72%)
Frame = +3
Query: 9 CFKEELKTIHAFTQKTLTVDQW 74
C EEL IHAF QKTLT DQW
Sbjct: 59 CLAEELPHIHAFEQKTLTPDQW 80
>UniRef50_Q8L1I2 Cluster: Mevalonate kinase; n=1; Paracoccus
zeaxanthinifaciens|Rep: Mevalonate kinase - Paracoccus
zeaxanthinifaciens
Length = 378
Score = 37.5 bits (83), Expect = 0.42
Identities = 15/24 (62%), Positives = 21/24 (87%)
Frame = +1
Query: 241 APGKVILHGEHSVVYGKTAIAVSL 312
APGK+IL GEHSV+YG A+A+++
Sbjct: 12 APGKLILSGEHSVLYGAPALAMAI 35
>UniRef50_A5EVP5 Cluster: GHMP kinase family protein; n=1;
Dichelobacter nodosus VCS1703A|Rep: GHMP kinase family
protein - Dichelobacter nodosus (strain VCS1703A)
Length = 303
Score = 37.5 bits (83), Expect = 0.42
Identities = 20/60 (33%), Positives = 32/60 (53%)
Frame = +1
Query: 226 TVSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQET 405
T+ SA G V++ GEH+VVYG+ AI ++ R + + N + + IH D + T
Sbjct: 2 TIETSASGSVMICGEHAVVYGQPAIVAAIAQRIRVRLTPRN---DDKITIHSALGDYEST 58
>UniRef50_A5EUV5 Cluster: GHMP kinase family protein; n=1;
Dichelobacter nodosus VCS1703A|Rep: GHMP kinase family
protein - Dichelobacter nodosus (strain VCS1703A)
Length = 352
Score = 37.5 bits (83), Expect = 0.42
Identities = 16/24 (66%), Positives = 20/24 (83%)
Frame = +1
Query: 241 APGKVILHGEHSVVYGKTAIAVSL 312
APGK+IL GEH+VVYG AI V++
Sbjct: 8 APGKLILSGEHAVVYGAPAIVVAV 31
>UniRef50_Q6LXL5 Cluster: Mevalonate kinase; n=5; Methanococcus|Rep:
Mevalonate kinase - Methanococcus maripaludis
Length = 317
Score = 37.5 bits (83), Expect = 0.42
Identities = 26/76 (34%), Positives = 43/76 (56%), Gaps = 1/76 (1%)
Frame = +1
Query: 232 SVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQETIP 411
++ P K+IL GEH+VV G AI+++L L+++ I+E + + I L VDL E
Sbjct: 3 TIKTPSKIILFGEHAVVDGYPAISMALDLKTTGEIEE----NFDTISIDL--VDLNEIFE 56
Query: 412 LEP-TVKSLFHPKLAP 456
+ P +K+L +P
Sbjct: 57 ITPELIKNLEISNFSP 72
>UniRef50_Q22LZ8 Cluster: ATPase, AAA family protein; n=1;
Tetrahymena thermophila SB210|Rep: ATPase, AAA family
protein - Tetrahymena thermophila SB210
Length = 741
Score = 37.1 bits (82), Expect = 0.55
Identities = 23/72 (31%), Positives = 40/72 (55%), Gaps = 1/72 (1%)
Frame = +1
Query: 142 LYLA*DLVNFACAYY-IKRTMLTAVDNLFTVSVSAPGKVILHGEHSVVYGKTAIAVSLGL 318
+Y + L+N+ AY I + M+ ++D + T S +++ G S+ GKTAIA + L
Sbjct: 502 VYKSNKLINYGEAYERISKQMIQSIDYVKTSENSLIHSILIEG--SIGTGKTAIAAAFAL 559
Query: 319 RSSIVIKEVNTP 354
+S I ++ TP
Sbjct: 560 KSDITYVKILTP 571
>UniRef50_A0E671 Cluster: Chromosome undetermined scaffold_8, whole
genome shotgun sequence; n=3; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_8,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 288
Score = 37.1 bits (82), Expect = 0.55
Identities = 16/34 (47%), Positives = 23/34 (67%)
Frame = +1
Query: 235 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVI 336
V AP K+I+ GEHSVVYG A+ ++ ++I I
Sbjct: 3 VRAPAKIIISGEHSVVYGHKALCAAINKYTTIKI 36
>UniRef50_UPI0000E24CC4 Cluster: PREDICTED: similar to bolA-like
protein 2B; n=2; Catarrhini|Rep: PREDICTED: similar to
bolA-like protein 2B - Pan troglodytes
Length = 145
Score = 36.3 bits (80), Expect = 0.97
Identities = 15/22 (68%), Positives = 16/22 (72%)
Frame = +3
Query: 9 CFKEELKTIHAFTQKTLTVDQW 74
C EEL IHAF QKTLT +QW
Sbjct: 118 CLAEELPHIHAFEQKTLTPEQW 139
>UniRef50_Q7QVN5 Cluster: GLP_305_18405_19430; n=1; Giardia lamblia
ATCC 50803|Rep: GLP_305_18405_19430 - Giardia lamblia
ATCC 50803
Length = 341
Score = 36.3 bits (80), Expect = 0.97
Identities = 18/31 (58%), Positives = 21/31 (67%)
Frame = +1
Query: 235 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSS 327
V P K IL GEHSVVYG IA++L L +S
Sbjct: 13 VRTPLKAILSGEHSVVYGHPCIAMALDLYTS 43
>UniRef50_Q83DT4 Cluster: Phosphomevalonate kinase, putative; n=2;
Coxiella burnetii|Rep: Phosphomevalonate kinase,
putative - Coxiella burnetii
Length = 313
Score = 35.9 bits (79), Expect = 1.3
Identities = 26/88 (29%), Positives = 42/88 (47%), Gaps = 4/88 (4%)
Frame = +1
Query: 241 APGKVILHGEHSVVYGKTAIAVSLGLRSSIVIK----EVNTPHEPAVHIHLPCVDLQETI 408
APG ++L GE++V+ GKTAI ++ SI + E P + L C ++ +
Sbjct: 7 APGSLMLLGEYAVLQGKTAIVAAIDKFISISLSPRHDEKINIDSPLGKLTLDCQSIKLSP 66
Query: 409 PLEPTVKSLFHPKLAPGXNRQILLEITP 492
P E + +L KL G + I + P
Sbjct: 67 PFEFVLAALASKKLPSGCDINIQSTLPP 94
>UniRef50_Q03FN7 Cluster: Mevalonate kinase; n=1; Pediococcus
pentosaceus ATCC 25745|Rep: Mevalonate kinase -
Pediococcus pentosaceus (strain ATCC 25745 / 183-1w)
Length = 306
Score = 35.9 bits (79), Expect = 1.3
Identities = 17/38 (44%), Positives = 28/38 (73%), Gaps = 1/38 (2%)
Frame = +1
Query: 238 SAPGKVILHGEHSVVYGKTAIAVSL-GLRSSIVIKEVN 348
S+ K+IL GEHSVVYG+ AIA+ + +++++ I+ N
Sbjct: 7 SSNSKIILIGEHSVVYGQPAIALPIRNVKTTVKIQPTN 44
>UniRef50_A6G138 Cluster: Mevalonate kinase; n=1; Plesiocystis
pacifica SIR-1|Rep: Mevalonate kinase - Plesiocystis
pacifica SIR-1
Length = 320
Score = 35.9 bits (79), Expect = 1.3
Identities = 22/52 (42%), Positives = 28/52 (53%)
Frame = +1
Query: 241 APGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDL 396
A GK+IL GEHSVVYG A+A L R I+ A+ + +P DL
Sbjct: 11 ACGKIILLGEHSVVYGHPALAAGLS-RGLILRARPLDGRGGAMELSIPAWDL 61
>UniRef50_A2U564 Cluster: Mevalonate kinase; n=1; Bacillus coagulans
36D1|Rep: Mevalonate kinase - Bacillus coagulans 36D1
Length = 314
Score = 35.5 bits (78), Expect = 1.7
Identities = 16/27 (59%), Positives = 22/27 (81%)
Frame = +1
Query: 226 TVSVSAPGKVILHGEHSVVYGKTAIAV 306
T + +A GK+IL GEH+VVYG+ AIA+
Sbjct: 8 TATGTAHGKLILAGEHAVVYGQPAIAL 34
>UniRef50_A2DPP4 Cluster: Phosphatidylinositol 3-and 4-kinase family
protein; n=1; Trichomonas vaginalis G3|Rep:
Phosphatidylinositol 3-and 4-kinase family protein -
Trichomonas vaginalis G3
Length = 2286
Score = 35.1 bits (77), Expect = 2.2
Identities = 27/86 (31%), Positives = 44/86 (51%), Gaps = 6/86 (6%)
Frame = +2
Query: 530 EYLHLIKPNFDSLPNNQKNSLRSFLYV----FSGIFGSTYLPVKS-MDISMGSELTIGAG 694
E+L + P F L + K+S RS + S F P++S + + SE+ +
Sbjct: 1779 EFLVKLLPRFVDLLSKDKSSCRSIAKIVITRLSYDFQKVVFPLRSKIHVKEVSEILLNLC 1838
Query: 695 TGSSASFAVCL-AGALIQLLKLKSSS 769
S ++ + + AG+LI LLK+KSSS
Sbjct: 1839 NSSEKNYKINVDAGSLINLLKMKSSS 1864
>UniRef50_Q6C8D7 Cluster: Yarrowia lipolytica chromosome D of strain
CLIB122 of Yarrowia lipolytica; n=3; Ascomycota|Rep:
Yarrowia lipolytica chromosome D of strain CLIB122 of
Yarrowia lipolytica - Yarrowia lipolytica (Candida
lipolytica)
Length = 84
Score = 35.1 bits (77), Expect = 2.2
Identities = 13/21 (61%), Positives = 18/21 (85%)
Frame = +3
Query: 15 KEELKTIHAFTQKTLTVDQWK 77
KEE+ IHAFTQK+ TV++W+
Sbjct: 59 KEEIAAIHAFTQKSQTVEEWE 79
>UniRef50_Q9FD69 Cluster: Mevalonate kinase; n=4; Enterococcus|Rep:
Mevalonate kinase - Enterococcus faecalis (Streptococcus
faecalis)
Length = 314
Score = 34.7 bits (76), Expect = 3.0
Identities = 15/21 (71%), Positives = 18/21 (85%)
Frame = +1
Query: 241 APGKVILHGEHSVVYGKTAIA 303
A GK+IL GEH+VVYG+ AIA
Sbjct: 11 ATGKIILMGEHAVVYGEPAIA 31
>UniRef50_Q2BIJ9 Cluster: GHMP kinase; n=1; Neptuniibacter
caesariensis|Rep: GHMP kinase - Neptuniibacter
caesariensis
Length = 309
Score = 34.7 bits (76), Expect = 3.0
Identities = 12/29 (41%), Positives = 22/29 (75%)
Frame = +1
Query: 226 TVSVSAPGKVILHGEHSVVYGKTAIAVSL 312
T+ V PG ++L GEH+V++G+ A+A ++
Sbjct: 3 TIKVKVPGSIMLMGEHAVLFGEKALACAV 31
>UniRef50_Q17N15 Cluster: Putative uncharacterized protein; n=1;
Aedes aegypti|Rep: Putative uncharacterized protein -
Aedes aegypti (Yellowfever mosquito)
Length = 456
Score = 34.7 bits (76), Expect = 3.0
Identities = 17/44 (38%), Positives = 26/44 (59%), Gaps = 2/44 (4%)
Frame = -1
Query: 844 PFRYNLLFGIRKXLAALIVICIEIPRRTLQ--FQQLYQCSC*TD 719
P Y++LFG++ L +I IC+ P RT++ FQ+ C C D
Sbjct: 375 PILYDILFGLQGILIFIIFICLPRPFRTVKAWFQKRELCGCVED 418
>UniRef50_Q2GZQ7 Cluster: Putative uncharacterized protein; n=1;
Chaetomium globosum|Rep: Putative uncharacterized
protein - Chaetomium globosum (Soil fungus)
Length = 460
Score = 34.7 bits (76), Expect = 3.0
Identities = 25/73 (34%), Positives = 39/73 (53%), Gaps = 1/73 (1%)
Frame = +1
Query: 226 TVSVSAPGKVILHGEHSVVYGK-TAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQE 402
TV VSAPGKV+L G + V+ K T + L R ++ +E++T + +HL + +Q
Sbjct: 12 TVVVSAPGKVLLAGGYIVLDRKHTGLVFGLSARIHVLAQEIHT----SAGVHLREIVVQS 67
Query: 403 TIPLEPTVKSLFH 441
L T K +H
Sbjct: 68 PQFLNATWKYGYH 80
>UniRef50_Q97UL6 Cluster: (Phospho) mevalonate kinase, putative;
n=4; Sulfolobaceae|Rep: (Phospho) mevalonate kinase,
putative - Sulfolobus solfataricus
Length = 323
Score = 34.7 bits (76), Expect = 3.0
Identities = 14/39 (35%), Positives = 26/39 (66%)
Frame = +1
Query: 229 VSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEV 345
+ VSAPGK++ G +SVV+G + +++ R S ++E+
Sbjct: 2 IKVSAPGKILWIGSYSVVFGGISHVIAVNKRVSCSLREI 40
>UniRef50_Q7XJS3 Cluster: At2g17440 protein; n=3; Brassicaceae|Rep:
At2g17440 protein - Arabidopsis thaliana (Mouse-ear
cress)
Length = 526
Score = 34.3 bits (75), Expect = 3.9
Identities = 17/37 (45%), Positives = 22/37 (59%)
Frame = -2
Query: 774 FPEELFNFNSCINAPARQTAKDAELPVPAPMVSSDPI 664
F E + + CI +P TA +PVPAP+VSSD I
Sbjct: 99 FDELIQRASFCIASPNSTTALPRSVPVPAPVVSSDEI 135
>UniRef50_A3DL21 Cluster: Mevalonate kinase; n=1; Staphylothermus
marinus F1|Rep: Mevalonate kinase - Staphylothermus
marinus (strain ATCC 43588 / DSM 3639 / F1)
Length = 324
Score = 34.3 bits (75), Expect = 3.9
Identities = 17/38 (44%), Positives = 23/38 (60%)
Frame = +1
Query: 238 SAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNT 351
+AP KVIL GEH VV K AI ++ L + I E+ +
Sbjct: 5 AAPAKVILFGEHFVVKDKPAIVTAVNLYAKTCITELES 42
>UniRef50_Q38X71 Cluster: Mevalonate kinase; n=1; Lactobacillus
sakei subsp. sakei 23K|Rep: Mevalonate kinase -
Lactobacillus sakei subsp. sakei (strain 23K)
Length = 315
Score = 33.9 bits (74), Expect = 5.2
Identities = 16/42 (38%), Positives = 29/42 (69%), Gaps = 1/42 (2%)
Frame = +1
Query: 250 KVILHGEHSVVYGKTAIAVSL-GLRSSIVIKEVNTPHEPAVH 372
K+IL GEH+VVYG+ AIA+ + +++++ + T EP ++
Sbjct: 11 KIILIGEHAVVYGQPAIALPIFAVQTTVRVTAQPTLSEPLIN 52
>UniRef50_A6GIJ2 Cluster: Putative uncharacterized protein; n=1;
Plesiocystis pacifica SIR-1|Rep: Putative
uncharacterized protein - Plesiocystis pacifica SIR-1
Length = 88
Score = 33.9 bits (74), Expect = 5.2
Identities = 17/46 (36%), Positives = 25/46 (54%)
Frame = +2
Query: 614 SGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQLL 751
+ + G TYL KS + G+ GA TG+ A+ AV L A + +L
Sbjct: 10 TAVGGGTYLYAKSKQATTGTAAVAGAATGAGAAGAVLLVQAALPIL 55
>UniRef50_A5VK03 Cluster: Mevalonate kinase; n=2; Lactobacillus
reuteri|Rep: Mevalonate kinase - Lactobacillus reuteri
F275
Length = 316
Score = 33.9 bits (74), Expect = 5.2
Identities = 15/21 (71%), Positives = 18/21 (85%)
Frame = +1
Query: 250 KVILHGEHSVVYGKTAIAVSL 312
K+IL GEHSVVYG+ AIA+ L
Sbjct: 13 KIILMGEHSVVYGQPAIALPL 33
>UniRef50_A4VT18 Cluster: Mevalonate kinase; n=4; Streptococcus|Rep:
Mevalonate kinase - Streptococcus suis (strain 05ZYH33)
Length = 317
Score = 33.9 bits (74), Expect = 5.2
Identities = 15/22 (68%), Positives = 18/22 (81%)
Frame = +1
Query: 241 APGKVILHGEHSVVYGKTAIAV 306
A GK+IL GEH+VVYG AIA+
Sbjct: 13 ANGKIILMGEHAVVYGHPAIAM 34
>UniRef50_Q0W4W9 Cluster: Predicted signal transduction histidine
kinase; n=1; uncultured methanogenic archaeon RC-I|Rep:
Predicted signal transduction histidine kinase -
Uncultured methanogenic archaeon RC-I
Length = 370
Score = 33.9 bits (74), Expect = 5.2
Identities = 16/49 (32%), Positives = 28/49 (57%), Gaps = 1/49 (2%)
Frame = -1
Query: 160 DLKQGIMNNKKLMDFDYCIVLNSIH-YCVFH*STVKVFWVNAWIVFSSS 17
DL++G+ ++ L D ++L SI Y ++H +K+ WVN + S S
Sbjct: 8 DLQKGLGDSALLSGLDISLILGSIDDYVLYHGPDMKILWVNRAVELSES 56
>UniRef50_Q8F618 Cluster: Putative uncharacterized protein; n=2;
Leptospira interrogans|Rep: Putative uncharacterized
protein - Leptospira interrogans
Length = 77
Score = 33.5 bits (73), Expect = 6.8
Identities = 19/39 (48%), Positives = 25/39 (64%), Gaps = 1/39 (2%)
Frame = +2
Query: 503 HDYHLRRVEEYLHLIKPN-FDSLPNNQKNSLRSFLYVFS 616
+DYHLR +E +L +K N F S + SL+SFLYV S
Sbjct: 2 YDYHLRVLERFLKNLKGNDFCSFYKLFRFSLQSFLYVMS 40
>UniRef50_Q83DT3 Cluster: Mevalonate kinase, putative; n=3; Coxiella
burnetii|Rep: Mevalonate kinase, putative - Coxiella
burnetii
Length = 340
Score = 33.5 bits (73), Expect = 6.8
Identities = 13/23 (56%), Positives = 19/23 (82%)
Frame = +1
Query: 244 PGKVILHGEHSVVYGKTAIAVSL 312
P K+IL GEH+VVYG A++V++
Sbjct: 11 PAKLILSGEHAVVYGHPALSVAI 33
>UniRef50_Q8H912 Cluster: Putative zinc knuckle domain containing
protein; n=3; Oryza sativa (japonica
cultivar-group)|Rep: Putative zinc knuckle domain
containing protein - Oryza sativa subsp. japonica (Rice)
Length = 910
Score = 33.5 bits (73), Expect = 6.8
Identities = 21/56 (37%), Positives = 26/56 (46%), Gaps = 2/56 (3%)
Frame = +3
Query: 276 GRVRKNCDRCQPRPKELHSDKGS--KHSTRTSSPHTFAVRGSTGDHSIGADSQKSV 437
GR R + D CQ R + HS + S S RT SP + RG G G + K V
Sbjct: 575 GRQRAHGDGCQGRSRTRHSSRCSCRCRSRRTRSPSSLTPRGQDGTGDAGGATTKVV 630
>UniRef50_Q60ED2 Cluster: Putative uncharacterized protein
OSJNBa0002D18.17; n=5; Oryza sativa|Rep: Putative
uncharacterized protein OSJNBa0002D18.17 - Oryza sativa
subsp. japonica (Rice)
Length = 911
Score = 33.5 bits (73), Expect = 6.8
Identities = 13/33 (39%), Positives = 20/33 (60%)
Frame = -1
Query: 415 PMEWSPVDPRTANVCGLLVRVECLLPLSLWSSL 317
P+E V + +N CG LVR CL+ + LW ++
Sbjct: 131 PVEPPIVQSKFSNTCGTLVRTHCLINVKLWETV 163
>UniRef50_Q8SQK4 Cluster: MEVALONATE KINASE; n=1; Encephalitozoon
cuniculi|Rep: MEVALONATE KINASE - Encephalitozoon
cuniculi
Length = 276
Score = 33.5 bits (73), Expect = 6.8
Identities = 18/54 (33%), Positives = 29/54 (53%)
Frame = +1
Query: 241 APGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQE 402
+P KVIL GEH V+ G +AV++ + + +K + + + CVDL E
Sbjct: 7 SPLKVILFGEHGVLSGGRCLAVAIDVYGYLAMKSSSINKAIIIDTNGNCVDLIE 60
>UniRef50_Q5KDZ6 Cluster: Putative uncharacterized protein; n=1;
Filobasidiella neoformans|Rep: Putative uncharacterized
protein - Cryptococcus neoformans (Filobasidiella
neoformans)
Length = 91
Score = 33.5 bits (73), Expect = 6.8
Identities = 12/22 (54%), Positives = 18/22 (81%)
Frame = +3
Query: 18 EELKTIHAFTQKTLTVDQWKTQ 83
EE+ +HAF+QKTLT +QW+ +
Sbjct: 67 EEIAQLHAFSQKTLTPEQWEKE 88
>UniRef50_UPI000155FB65 Cluster: PREDICTED: similar to BolA-like
protein 2; n=2; Theria|Rep: PREDICTED: similar to
BolA-like protein 2 - Equus caballus
Length = 162
Score = 33.1 bits (72), Expect = 9.0
Identities = 14/22 (63%), Positives = 15/22 (68%)
Frame = +3
Query: 9 CFKEELKTIHAFTQKTLTVDQW 74
C +EL IHAF QKTLT QW
Sbjct: 135 CLAKELLDIHAFEQKTLTPRQW 156
>UniRef50_Q08UJ8 Cluster: Mevalonate kinase; n=2;
Cystobacterineae|Rep: Mevalonate kinase - Stigmatella
aurantiaca DW4/3-1
Length = 310
Score = 33.1 bits (72), Expect = 9.0
Identities = 15/19 (78%), Positives = 16/19 (84%)
Frame = +1
Query: 247 GKVILHGEHSVVYGKTAIA 303
GKVIL GEHSVVYG A+A
Sbjct: 14 GKVILLGEHSVVYGHPALA 32
>UniRef50_Q031R4 Cluster: Mevalonate kinase; n=3; Lactococcus
lactis|Rep: Mevalonate kinase - Lactococcus lactis
subsp. cremoris (strain SK11)
Length = 310
Score = 33.1 bits (72), Expect = 9.0
Identities = 16/31 (51%), Positives = 22/31 (70%)
Frame = +1
Query: 241 APGKVILHGEHSVVYGKTAIAVSLGLRSSIV 333
A K+IL GEHSVVYG+ AIA+ + + + V
Sbjct: 11 AHSKLILIGEHSVVYGQPAIALPVTILKTTV 41
>UniRef50_Q6C026 Cluster: Similarity; n=1; Yarrowia lipolytica|Rep:
Similarity - Yarrowia lipolytica (Candida lipolytica)
Length = 273
Score = 33.1 bits (72), Expect = 9.0
Identities = 26/104 (25%), Positives = 52/104 (50%), Gaps = 6/104 (5%)
Frame = +1
Query: 256 ILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQET-IPLEPTVKS 432
+L G+ ++Y K V + ++ ++ P ++ +H L++T +P+E +K
Sbjct: 110 LLGGKALLLYRKQKNQVLPWVELKRLVHTLDKPVLRSIAVHKELAKLEDTDLPIEYRIKM 169
Query: 433 LFH--PKLAPG--XNRQI-LLEITPQNRP*LSLAKGGGIPAFDQ 549
+ H P+L P +R + ++ I P+ + A GGI +FDQ
Sbjct: 170 IRHWEPQLDPSPLGDRVVEVIRIIPEKEADIMKAVEGGISSFDQ 213
>UniRef50_Q8ZTT2 Cluster: Mevalonate kinase; n=4; Pyrobaculum|Rep:
Mevalonate kinase - Pyrobaculum aerophilum
Length = 314
Score = 33.1 bits (72), Expect = 9.0
Identities = 14/28 (50%), Positives = 19/28 (67%)
Frame = +1
Query: 229 VSVSAPGKVILHGEHSVVYGKTAIAVSL 312
V + P V L GEH+VVYGK AI+ ++
Sbjct: 2 VKIFVPAAVKLFGEHAVVYGKPAISAAI 29
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 917,549,773
Number of Sequences: 1657284
Number of extensions: 20227373
Number of successful extensions: 55945
Number of sequences better than 10.0: 88
Number of HSP's better than 10.0 without gapping: 53173
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 55920
length of database: 575,637,011
effective HSP length: 100
effective length of database: 409,908,611
effective search space used: 74193458591
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
- SilkBase 1999-2023 -