Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fcaL-P17_F_H15
(674 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8; Bilateri... 264 1e-69
UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p... 260 2e-68
UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 186 4e-46
UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella ve... 169 4e-41
UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 155 9e-37
UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma... 151 1e-35
UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 148 1e-34
UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;... 139 7e-32
UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulato... 133 3e-30
UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulato... 132 1e-29
UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 130 3e-29
UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]... 115 9e-25
UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate... 111 1e-23
UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalyti... 111 2e-23
UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 106 4e-22
UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 102 7e-21
UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3; Bacteria... 96 8e-19
UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep: C... 88 2e-16
UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421, ... 82 1e-14
UniRef50_Q2Q9C5 Cluster: Isocitrate dehydrogenase 3 gamma; n=8; ... 81 3e-14
UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 79 7e-14
UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3; Ricketts... 77 5e-13
UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependen... 76 9e-13
UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate dehydrog... 75 1e-12
UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1... 74 3e-12
UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2; Bacteria... 74 4e-12
UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9; Eut... 73 5e-12
UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]... 71 2e-11
UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD] s... 69 1e-10
UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6; T... 68 2e-10
UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68; Bacteri... 67 4e-10
UniRef50_Q4V533 Cluster: IP13250p; n=4; Drosophila melanogaster|... 67 4e-10
UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1; Ent... 65 2e-09
UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6; E... 58 2e-07
UniRef50_Q2VF40 Cluster: Isocitrate dehydrogenase 3 gamma subuni... 57 3e-07
UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 56 6e-07
UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8; E... 56 1e-06
UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate dehydrog... 54 4e-06
UniRef50_Q5HNL1 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 52 1e-05
UniRef50_A5DIP7 Cluster: Putative uncharacterized protein; n=1; ... 51 2e-05
UniRef50_P41566 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 47 3e-05
UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10; ... 51 3e-05
UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3; P... 50 7e-05
UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;... 47 4e-04
UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5; C... 47 4e-04
UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependen... 47 4e-04
UniRef50_A5URE6 Cluster: Isocitrate dehydrogenase, NADP-dependen... 47 5e-04
UniRef50_A7T3D9 Cluster: Predicted protein; n=1; Nematostella ve... 46 6e-04
UniRef50_Q0W1Q6 Cluster: 2-isopropylmalate dehydrogenase; n=5; E... 46 8e-04
UniRef50_Q0X0C1 Cluster: Putative dehydrogenase; n=1; Streptomyc... 44 0.003
UniRef50_A5DIP6 Cluster: Putative uncharacterized protein; n=1; ... 44 0.004
UniRef50_Q9CKK6 Cluster: Idp; n=2; Pasteurellaceae|Rep: Idp - Pa... 43 0.008
UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenas... 43 0.008
UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 43 0.008
UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9; B... 42 0.010
UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 42 0.010
UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2; Alp... 42 0.014
UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase, mitochond... 42 0.014
UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5; T... 42 0.018
UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;... 41 0.032
UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase; n... 40 0.073
UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for ... 38 0.17
UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 38 0.22
UniRef50_A6G3V7 Cluster: Probable 3-isopropylmalate dehydrogenas... 37 0.39
UniRef50_Q9RTT2 Cluster: Isocitrate dehydrogenase, putative; n=2... 37 0.51
UniRef50_A1SM34 Cluster: 3-isopropylmalate dehydrogenase; n=1; N... 37 0.51
UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: Leu... 36 0.68
UniRef50_P56471 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 36 0.68
UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular ... 36 1.2
UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1; S... 36 1.2
UniRef50_A6PN62 Cluster: 3-isopropylmalate dehydrogenase; n=1; V... 35 1.6
UniRef50_A5UWW1 Cluster: Agmatine deiminase; n=9; cellular organ... 35 1.6
UniRef50_A0E5I0 Cluster: Chromosome undetermined scaffold_8, who... 35 2.1
UniRef50_Q6L2P9 Cluster: Isocitrate dehydrogenase [NADP]; n=2; T... 35 2.1
UniRef50_A3Y262 Cluster: Phosphorelay protein; n=4; Vibrionales|... 34 2.7
UniRef50_P35484 Cluster: Dihydrolipoyl dehydrogenase; n=3; Achol... 34 2.7
UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2; Bacillacea... 34 3.6
UniRef50_Q6C705 Cluster: Similar to DEHA0E18414g Debaryomyces ha... 34 3.6
UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;... 34 3.6
UniRef50_A3W960 Cluster: SCO1/SenC family protein; n=2; Roseovar... 33 4.8
UniRef50_Q8IC48 Cluster: Putative uncharacterized protein PF07_0... 33 4.8
UniRef50_UPI000065D57A Cluster: Putative polypeptide N-acetylgal... 33 8.4
UniRef50_Q08KN2 Cluster: FIg-Hepta; n=3; Takifugu rubripes|Rep: ... 33 8.4
UniRef50_Q67N12 Cluster: 3-isopropylmalate dehydrogenase; n=5; B... 33 8.4
UniRef50_A4C445 Cluster: VCBS; n=1; Pseudoalteromonas tunicata D... 33 8.4
UniRef50_A0P1S6 Cluster: 3-isopropylmalate dehydrogenase; n=2; R... 33 8.4
UniRef50_O14122 Cluster: Cullin-4; n=1; Schizosaccharomyces pomb... 33 8.4
>UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8;
Bilateria|Rep: Isocitrate dehydrogenase - Aedes aegypti
(Yellowfever mosquito)
Length = 393
Score = 264 bits (647), Expect = 1e-69
Identities = 119/173 (68%), Positives = 145/173 (83%)
Frame = +2
Query: 155 SDFDVQHKPPVIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEV 334
S F++QHK P+ RK + IPKA YGGRH VTMLPGGGIGPE M YV+++F++ G P+DFEV
Sbjct: 24 SAFELQHKNPLQRKVEKIPKAHYGGRHTVTMLPGGGIGPELMNYVKEVFRFAGVPVDFEV 83
Query: 335 VDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNC 514
VDIDP + +DD++YAIT+IKRNGV LKGNIETKSEA + SRNVALRNELD+Y +L+C
Sbjct: 84 VDIDPASEGNDDLEYAITSIKRNGVALKGNIETKSEATGIISRNVALRNELDLYVNVLHC 143
Query: 515 KSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSXRVA 673
KS+ + H+++DVVIIRQNTEGEYAMLEHESV GVVESMKVVT +N+ RVA
Sbjct: 144 KSFNAIPAHHQNVDVVIIRQNTEGEYAMLEHESVRGVVESMKVVTVENAARVA 196
>UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p -
Drosophila melanogaster (Fruit fly)
Length = 402
Score = 260 bits (638), Expect = 2e-68
Identities = 120/173 (69%), Positives = 144/173 (83%), Gaps = 3/173 (1%)
Frame = +2
Query: 164 DVQHKPPVIRKQKL---IPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEV 334
DV H ++K+ IP AQYGGRHAVTMLPGGGIGPE MGYVR+IF+Y GAPIDFEV
Sbjct: 32 DVAHTKSALQKKVTGTDIPSAQYGGRHAVTMLPGGGIGPELMGYVREIFRYCGAPIDFEV 91
Query: 335 VDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNC 514
+DIDP+ + +DD+ YAIT+IKRNGV LKGNIETKS++ SRNVA+RNELD+Y +++C
Sbjct: 92 IDIDPSTEGNDDLDYAITSIKRNGVALKGNIETKSQSLTEVSRNVAIRNELDLYVNVVHC 151
Query: 515 KSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSXRVA 673
KSYPG+ RH DIDVV+IRQNT+GEYAMLEHESV G+VESMKVVT +N+ RVA
Sbjct: 152 KSYPGIPARHHDIDVVLIRQNTDGEYAMLEHESVPGIVESMKVVTVENAERVA 204
>UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=50;
Deuterostomia|Rep: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 393
Score = 186 bits (453), Expect = 4e-46
Identities = 87/164 (53%), Positives = 117/164 (71%), Gaps = 1/164 (0%)
Frame = +2
Query: 185 VIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDND 364
+ +Q + P A+YGGRH VTM+PG GIGPE M +V+ +F++ P+DFE V + D +
Sbjct: 39 IFSEQTIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVSSNAD-E 97
Query: 365 DDVQYAITTIKRNGVGLKGNIETKSEAAYV-TSRNVALRNELDMYAYILNCKSYPGVATR 541
+D++ AI I+RN V LKGNIET SRN LR LD+YA +++CKS PGV TR
Sbjct: 98 EDIRNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTR 157
Query: 542 HKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSXRVA 673
HKDID++I+R+NTEGEY+ LEHESV GVVES+K++T S R+A
Sbjct: 158 HKDIDILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIA 201
>UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 394
Score = 169 bits (412), Expect = 4e-41
Identities = 90/195 (46%), Positives = 129/195 (66%), Gaps = 12/195 (6%)
Frame = +2
Query: 125 LSSKAAPATLSDFDVQHKPPVIRKQ------KLIPKAQYGGRHAVTMLPGGGIGPECMGY 286
LS++ + L V+ P VI+K + P A+YGGR+ VT++PG GIGPE +
Sbjct: 9 LSNRFSRPNLLQATVRAAPQVIKKNLAYHPHHVPPPARYGGRNTVTLIPGDGIGPEMVVA 68
Query: 287 VRDIFKYIGAPIDFEVVDIDPTMDNDDD-----VQYAITTIKRNGVGLKGNIETKSEAAY 451
V+DIF++IG P+DFE +++ D+D AIT+IKRNGV +KGNI T +A
Sbjct: 69 VQDIFRHIGVPVDFEELNLSGLDIKDEDSYLGAFNEAITSIKRNGVAMKGNIFTPLDAIP 128
Query: 452 -VTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVV 628
S N+ LR LD++A I+ CKS PG+ TRH ++D+VIIRQNTEGEY+ LEHE+V+GV+
Sbjct: 129 GFRSLNLELRVHLDLFANIVRCKSIPGIQTRHNNVDLVIIRQNTEGEYSHLEHENVSGVI 188
Query: 629 ESMKVVTADNSXRVA 673
E++KV T + ++A
Sbjct: 189 ENLKVTTEEACMKIA 203
>UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1;
Kluyveromyces lactis|Rep: Isocitrate dehydrogenase [NAD]
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Kluyveromyces lactis (Yeast) (Candida sphaerica)
Length = 361
Score = 155 bits (376), Expect = 9e-37
Identities = 80/159 (50%), Positives = 112/159 (70%)
Frame = +2
Query: 197 QKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQ 376
++L+PK +YGGR+ VT++PG G+G E V IF+ PID+E +DI ++N ++VQ
Sbjct: 19 EQLLPK-KYGGRYTVTLIPGDGVGKEVTDSVVKIFENENIPIDWETIDISG-LENTENVQ 76
Query: 377 YAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDID 556
A+ ++KRN VGLKG T ++ S NVALR +LD++A + KS PGV TR +ID
Sbjct: 77 RAVESLKRNKVGLKGIWHTPADQTGHGSLNVALRKQLDIFANVALFKSIPGVKTRLNNID 136
Query: 557 VVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSXRVA 673
+VIIR+NTEGEY+ LEHESV GVVES+K++T S R+A
Sbjct: 137 MVIIRENTEGEYSGLEHESVPGVVESLKIMTRAKSERIA 175
>UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma;
n=1; Danio rerio|Rep: Isocitrate dehydrogenase 3 (NAD+)
gamma - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 289
Score = 151 bits (367), Expect = 1e-35
Identities = 70/163 (42%), Positives = 107/163 (65%), Gaps = 1/163 (0%)
Frame = +2
Query: 170 QHKPPVIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDP 349
Q P + + P A+YGGRH VT++PG GIGPE + +VR++F++ P+DFEVV ++
Sbjct: 30 QRGKPTYSGRIIPPPAKYGGRHTVTLIPGDGIGPELLNHVRELFRFSCVPVDFEVVHVNS 89
Query: 350 TMDNDDDVQYAITTIKRNGVGLKGNIETK-SEAAYVTSRNVALRNELDMYAYILNCKSYP 526
+ ++DD+ AI I+RNGV LKGNIET + SRN LR LD+YA +++C+S P
Sbjct: 90 SSTSEDDISNAIMAIRRNGVALKGNIETNHTMPPNHKSRNNLLRTSLDLYANVMHCQSLP 149
Query: 527 GVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTAD 655
GV TRHK+ID++II + +E + E+E + + +++ AD
Sbjct: 150 GVQTRHKNIDIIIILEKSEFSALLAENEKIKVELLQLRIQLAD 192
>UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=32;
Dikarya|Rep: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 360
Score = 148 bits (358), Expect = 1e-34
Identities = 76/159 (47%), Positives = 108/159 (67%)
Frame = +2
Query: 197 QKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQ 376
++ +PK +YGGR VT++PG G+G E VR IF+ PID+E ++I T D+ + V
Sbjct: 18 ERTLPK-KYGGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQT-DHKEGVY 75
Query: 377 YAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDID 556
A+ ++KRN +GLKG T ++ S NVALR +LD+YA + KS GV TR DID
Sbjct: 76 EAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDID 135
Query: 557 VVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSXRVA 673
+++IR+NTEGE++ LEHESV GVVES+KV+T + R+A
Sbjct: 136 LIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIA 174
>UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;
Glossina morsitans morsitans|Rep: Isocitrate
dehydrogenase (NAD+) 2 - Glossina morsitans morsitans
(Savannah tsetse fly)
Length = 372
Score = 139 bits (336), Expect = 7e-32
Identities = 68/160 (42%), Positives = 107/160 (66%), Gaps = 5/160 (3%)
Frame = +2
Query: 209 PKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFE---VVDIDPTMDNDDDVQY 379
P A G R T++PG G+GPE + ++++FK P+DFE + +++P + ++
Sbjct: 32 PGALGGNRTTCTLIPGDGVGPELVQCLQEVFKSADVPVDFECYFLSEVNPVLSAK--LED 89
Query: 380 AITTIKRNGVGLKGNIETK--SEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDI 553
I +I++N V +KG + T S + S N+ LRNELD+YA +++ +S PGV TR++DI
Sbjct: 90 VIASIRKNKVCIKGVLATPDYSNVGELQSLNMKLRNELDLYANVVHARSLPGVKTRYQDI 149
Query: 554 DVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSXRVA 673
D+V+IR+ TEGEY+ LEHESV G+VE +K++TA S R+A
Sbjct: 150 DIVVIREQTEGEYSALEHESVPGIVECLKIITAKKSMRIA 189
>UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 1) (NAD(+)-specific ICDH 1);
n=7; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 1, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 1) (NAD(+)-specific
ICDH 1) - Arabidopsis thaliana (Mouse-ear cress)
Length = 367
Score = 133 bits (322), Expect = 3e-30
Identities = 71/161 (44%), Positives = 101/161 (62%)
Frame = +2
Query: 191 RKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDD 370
R +P+ G AVT++PG GIGP V + + + API FE D+ M
Sbjct: 24 RSVTYMPRPGDGAPRAVTLIPGDGIGPLVTNAVEQVMEAMHAPIFFEKYDVHGEMSRVPP 83
Query: 371 VQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKD 550
+ +I++N V LKG ++T V+S NV LR ELD++A ++NC + PG+ TRH++
Sbjct: 84 E--VMESIRKNKVCLKGGLKTPVGGG-VSSLNVQLRKELDLFASLVNCFNLPGLPTRHEN 140
Query: 551 IDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSXRVA 673
+D+V+IR+NTEGEYA LEHE V GVVES+KV+T S R+A
Sbjct: 141 VDIVVIRENTEGEYAGLEHEVVPGVVESLKVITKFCSERIA 181
>UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 3, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 3) (NAD(+)-specific ICDH 3);
n=23; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 3, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 3) (NAD(+)-specific
ICDH 3) - Arabidopsis thaliana (Mouse-ear cress)
Length = 368
Score = 132 bits (318), Expect = 1e-29
Identities = 68/156 (43%), Positives = 100/156 (64%)
Frame = +2
Query: 206 IPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAI 385
+P+ G VT++PG GIGP G V + + + AP+ FE ++ M + I
Sbjct: 30 MPRPGDGAPRTVTLIPGDGIGPLVTGAVEQVMEAMHAPVHFERYEVLGNMRKVPEE--VI 87
Query: 386 TTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVI 565
++KRN V LKG + T V+S N+ LR ELD++A ++NC + PG+ TRH+++D+V+
Sbjct: 88 ESVKRNKVCLKGGLATPVGGG-VSSLNMQLRKELDIFASLVNCINVPGLVTRHENVDIVV 146
Query: 566 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSXRVA 673
IR+NTEGEY+ LEHE V GVVES+KV+T S R+A
Sbjct: 147 IRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIA 182
>UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit
beta, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=61;
Fungi/Metazoa group|Rep: Isocitrate dehydrogenase [NAD]
subunit beta, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 385
Score = 130 bits (314), Expect = 3e-29
Identities = 62/152 (40%), Positives = 98/152 (64%), Gaps = 3/152 (1%)
Frame = +2
Query: 227 GRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPT--MDNDDDVQYAITTIKR 400
G VTMLPG G+GPE M V+++FK P++F+ + M +++ ++ ++++K
Sbjct: 47 GSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKE 106
Query: 401 NGVGLKGNIETKSE-AAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQN 577
N V + G I T E + S ++ LR +LD++A +++ KS PG TRH ++D+VIIR+
Sbjct: 107 NKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQ 166
Query: 578 TEGEYAMLEHESVNGVVESMKVVTADNSXRVA 673
TEGEY+ LEHES GV+E +K+VT S R+A
Sbjct: 167 TEGEYSSLEHESARGVIECLKIVTRAKSQRIA 198
>UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH); n=6;
Eukaryota|Rep: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Caenorhabditis elegans
Length = 358
Score = 115 bits (277), Expect = 9e-25
Identities = 64/153 (41%), Positives = 90/153 (58%), Gaps = 3/153 (1%)
Frame = +2
Query: 224 GGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQY---AITTI 394
G VT++PG GIGPE V+ IF+ API ++ VD+ P D + I +
Sbjct: 22 GDVRRVTLIPGDGIGPEISASVQKIFEAADAPIAWDPVDVTPVKGRDGVFRIPSRCIELM 81
Query: 395 KRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQ 574
N VGLKG +ET + S N+A+R E +YA + C+S G T + ++DVV IR+
Sbjct: 82 HANKVGLKGPLETPIGKGH-RSLNLAVRKEFSLYANVRPCRSLEGHKTLYDNVDVVTIRE 140
Query: 575 NTEGEYAMLEHESVNGVVESMKVVTADNSXRVA 673
NTEGEY+ +EHE V GVV+S+K++T S VA
Sbjct: 141 NTEGEYSGIEHEIVPGVVQSIKLITETASRNVA 173
>UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8; n=1; Pan
troglodytes|Rep: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8 - Pan troglodytes
Length = 331
Score = 111 bits (267), Expect = 1e-23
Identities = 54/138 (39%), Positives = 86/138 (62%), Gaps = 3/138 (2%)
Frame = +2
Query: 227 GRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPT--MDNDDDVQYAITTIKR 400
G VTMLPG G+GPE M V+++FK P++F+ + M +++ ++ ++++K
Sbjct: 47 GSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKE 106
Query: 401 NGVGLKGNIETKSE-AAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQN 577
N V + G I T E + S ++ LR +LD++A +++ KS PG TRH ++D+VIIR+
Sbjct: 107 NKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQ 166
Query: 578 TEGEYAMLEHESVNGVVE 631
TEGEY+ LEHE V E
Sbjct: 167 TEGEYSSLEHECCEEVAE 184
>UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalytic
subunit 6, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 6) (NAD(+)-specific ICDH 6);
n=10; cellular organisms|Rep: Isocitrate dehydrogenase
[NAD] catalytic subunit 6, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 6) (NAD(+)-specific
ICDH 6) - Arabidopsis thaliana (Mouse-ear cress)
Length = 374
Score = 111 bits (266), Expect = 2e-23
Identities = 61/148 (41%), Positives = 88/148 (59%), Gaps = 4/148 (2%)
Frame = +2
Query: 242 TMLPGGGIGPECMGYVRDIFKYIGAPIDFEV----VDIDPTMDNDDDVQYAITTIKRNGV 409
T+ PG GIGPE V+ +F ID++ ++DP N + ++ +N V
Sbjct: 47 TLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFVGTEVDPRT-NSFLTWDNLQSVLKNKV 105
Query: 410 GLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGE 589
GLKG + T + S N+ LR EL++YA + C S PG TR+ D+D++ IR+NTEGE
Sbjct: 106 GLKGPMATPIGKGH-RSLNLTLRKELNLYANVRPCYSLPGYKTRYDDVDLITIRENTEGE 164
Query: 590 YAMLEHESVNGVVESMKVVTADNSXRVA 673
Y+ LEH+ V GVVES+K++T S RVA
Sbjct: 165 YSGLEHQVVKGVVESLKIITRKASMRVA 192
>UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=62;
Eukaryota|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Homo sapiens
(Human)
Length = 366
Score = 106 bits (255), Expect = 4e-22
Identities = 65/182 (35%), Positives = 96/182 (52%), Gaps = 3/182 (1%)
Frame = +2
Query: 137 AAPATLSDFDVQHKPPVIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGA 316
A PA +S V K + + GG VT++PG GIGPE V IF A
Sbjct: 2 AGPAWISK--VSRLLGAFHNPKQVTRGFTGGVQTVTLIPGDGIGPEISAAVMKIFDAAKA 59
Query: 317 PIDFEVVDIDPTMDNDDDVQY---AITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNEL 487
PI +E ++ A ++ +N +GLKG ++T A + S N+ LR
Sbjct: 60 PIQWEERNVTAIQGPGGKWMIPSEAKESMDKNKMGLKGPLKTPIAAGH-PSMNLLLRKTF 118
Query: 488 DMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSXR 667
D+YA + C S G T + D+++V IR+NTEGEY+ +EH V+GVV+S+K++T S R
Sbjct: 119 DLYANVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEGASKR 178
Query: 668 VA 673
+A
Sbjct: 179 IA 180
>UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=31; cellular
organisms|Rep: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 369
Score = 102 bits (245), Expect = 7e-21
Identities = 56/150 (37%), Positives = 86/150 (57%), Gaps = 2/150 (1%)
Frame = +2
Query: 227 GRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDV--QYAITTIKR 400
G++ V+ + G GIGPE V+ IF PI++E D+ P N A+ +I +
Sbjct: 35 GKYTVSFIEGDGIGPEISKSVKKIFSAANVPIEWESCDVSPIFVNGLTTIPDPAVQSITK 94
Query: 401 NGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNT 580
N V LKG + T + S N+ LR ++A + KS G T ++++D+V+IR+NT
Sbjct: 95 NLVALKGPLATPIGKGH-RSLNLTLRKTFGLFANVRPAKSIEGFKTTYENVDLVLIRENT 153
Query: 581 EGEYAMLEHESVNGVVESMKVVTADNSXRV 670
EGEY+ +EH GVV+S+K++T D S RV
Sbjct: 154 EGEYSGIEHIVCPGVVQSIKLITRDASERV 183
>UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3;
Bacteria|Rep: Isocitrate dehydrogenase - Acidobacteria
bacterium (strain Ellin345)
Length = 348
Score = 95.9 bits (228), Expect = 8e-19
Identities = 50/150 (33%), Positives = 86/150 (57%), Gaps = 3/150 (2%)
Frame = +2
Query: 233 HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFE--VVDIDPTMDNDDDVQYAIT-TIKRN 403
+ +T++PG GIGPE + + G ++E + + + + +I+R
Sbjct: 3 YKITLIPGDGIGPEVTSAAVRVLEATGLKFEWESFAAGAEAYEKYKEYIPKELNESIERT 62
Query: 404 GVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTE 583
+GLKG + T + +S NV LR ++YA + ++ PGV TR+ +D+V++R+NTE
Sbjct: 63 RIGLKGPVTTPIGGGF-SSINVELRKRFELYANVRPIRNLPGVHTRYPGVDLVVVRENTE 121
Query: 584 GEYAMLEHESVNGVVESMKVVTADNSXRVA 673
G Y+ +EHE V GVVES+K++T S R++
Sbjct: 122 GLYSGIEHEVVPGVVESLKIITEKASTRIS 151
>UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep:
CG3483 protein - Drosophila melanogaster (Fruit fly)
Length = 391
Score = 87.8 bits (208), Expect = 2e-16
Identities = 46/145 (31%), Positives = 82/145 (56%)
Frame = +2
Query: 239 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLK 418
VT++ G G+G E M V+++ + API+++V D D+DD + +++ N VG+K
Sbjct: 72 VTLINGEGVGRELMDAVQEVICAVKAPIEWDVHDEFKAKDSDDVSPEVLKSLRANKVGIK 131
Query: 419 GNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAM 598
G ++++ + R + +AY+ C G+ + + D DVVIIR EG+Y+
Sbjct: 132 GPVDSRHWQRQI-------RKQFAQFAYVSLCSHIEGLDSPYGDFDVVIIRDQMEGDYSG 184
Query: 599 LEHESVNGVVESMKVVTADNSXRVA 673
+EH V GV++++KV T + R+A
Sbjct: 185 IEHLVVPGVMQTIKVSTTAGAARIA 209
>UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421,
highly similar to PROTEIN KINASE C-BINDING PROTEIN
NELL1; n=2; Homo sapiens|Rep: CDNA FLJ36019 fis, clone
TESTI2016421, highly similar to PROTEIN KINASE C-BINDING
PROTEIN NELL1 - Homo sapiens (Human)
Length = 355
Score = 81.8 bits (193), Expect = 1e-14
Identities = 34/67 (50%), Positives = 50/67 (74%)
Frame = +2
Query: 473 LRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTA 652
L LD+YA +++ K+ P V T HKD+D++++ +NTEGEY+ LEHESV GV ES+K++T
Sbjct: 2 LHTTLDLYASVIHLKNLPNVETWHKDVDILVVWENTEGEYSNLEHESVKGVTESLKIMTK 61
Query: 653 DNSXRVA 673
S R+A
Sbjct: 62 AKSLRIA 68
>UniRef50_Q2Q9C5 Cluster: Isocitrate dehydrogenase 3 gamma; n=8;
Eutheria|Rep: Isocitrate dehydrogenase 3 gamma - Homo
sapiens (Human)
Length = 88
Score = 80.6 bits (190), Expect = 3e-14
Identities = 36/78 (46%), Positives = 52/78 (66%)
Frame = +2
Query: 185 VIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDND 364
+ +Q + P A+YGGRH VTM+PG GIGPE M +V+ +F++ P+DFE V + D +
Sbjct: 12 IFSEQTIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVSSNAD-E 70
Query: 365 DDVQYAITTIKRNGVGLK 418
+D+ AI I+RN V LK
Sbjct: 71 EDICNAIMAIRRNRVALK 88
>UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=5; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) - Thermus
thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Length = 496
Score = 79.4 bits (187), Expect = 7e-14
Identities = 47/154 (30%), Positives = 81/154 (52%), Gaps = 6/154 (3%)
Frame = +2
Query: 227 GRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDN----DDDVQYAITTI 394
GR +T++PG GIGPEC+ + + AP+ +EV + ++ Q I +I
Sbjct: 18 GRKLITVIPGDGIGPECVEATLKVLEAAKAPLAYEVREAGASVFRRGIASGVPQETIESI 77
Query: 395 KRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRH--KDIDVVII 568
++ V LKG +ET S NV LR + YA + + +P V T + + ID+V++
Sbjct: 78 RKTRVVLKGPLETPVGYG-EKSANVTLRKLFETYANVRPVREFPNVPTPYAGRGIDLVVV 136
Query: 569 RQNTEGEYAMLEHESVNGVVESMKVVTADNSXRV 670
R+N E YA +EH V +++K+++ S ++
Sbjct: 137 RENVEDLYAGIEHMQTPSVAQTLKLISWKGSEKI 170
>UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3;
Rickettsiales|Rep: Isocitrate dehydrogenase - Anaplasma
marginale (strain St. Maries)
Length = 488
Score = 76.6 bits (180), Expect = 5e-13
Identities = 52/149 (34%), Positives = 73/149 (48%), Gaps = 5/149 (3%)
Frame = +2
Query: 239 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQ----YAITTIKRNG 406
+T+ G G+GPE M V I K A + E VDI + A +I R
Sbjct: 10 ITVAYGDGVGPEIMEAVLFILKEARADVSIETVDIGHNQYKKEWTSGIAPSAWESISRTR 69
Query: 407 VGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSY-PGVATRHKDIDVVIIRQNTE 583
+ LK T + + S NVALR L +Y + C SY P V T+H D+DVVIIR+N E
Sbjct: 70 LLLKAPTMTPQGSGH-KSLNVALRQRLGLYVNVRPCVSYFPVVGTKHPDLDVVIIRENEE 128
Query: 584 GEYAMLEHESVNGVVESMKVVTADNSXRV 670
Y+ +EH+ E +K+ T S ++
Sbjct: 129 DTYSGVEHKLSEDTHECVKISTRSASEKI 157
>UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=6; Rickettsiales|Rep: Isocitrate dehydrogenase,
NADP-dependent - Orientia tsutsugamushi (strain Boryong)
(Rickettsia tsutsugamushi)
Length = 519
Score = 75.8 bits (178), Expect = 9e-13
Identities = 53/150 (35%), Positives = 74/150 (49%), Gaps = 6/150 (4%)
Frame = +2
Query: 239 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITT-----IKRN 403
VT+ G GIGPE M V + K P+ E ++I + N Y IT I R
Sbjct: 7 VTIAYGDGIGPEIMEAVVYVLKEAAVPLRLETIEIGEKLYNKY-YTYGITEDTWSQIFRT 65
Query: 404 GVGLKGNIETKSEAAYVTSRNVALRNELDMYAYIL-NCKSYPGVATRHKDIDVVIIRQNT 580
LKG + T Y S NV LR L +YA + +C +P V T +IDVVIIR+N
Sbjct: 66 KALLKGPVTTPQGGGY-KSLNVTLRKTLGLYANVRPSCSYFPFVNTSAPEIDVVIIRENE 124
Query: 581 EGEYAMLEHESVNGVVESMKVVTADNSXRV 670
E YA +E+ ES+K+++ S ++
Sbjct: 125 EDLYAGIEYHHTADTYESVKLISRSGSEKI 154
>UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase family protein; n=9; Bacteria|Rep:
Isopropylmalate/isohomocitrate dehydrogenase family
protein - Synechococcus sp. (strain JA-3-3Ab)
(Cyanobacteria bacteriumYellowstone A-Prime)
Length = 368
Score = 75.4 bits (177), Expect = 1e-12
Identities = 44/131 (33%), Positives = 73/131 (55%), Gaps = 5/131 (3%)
Frame = +2
Query: 233 HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDV-----QYAITTIK 397
+ VT++PG GIGPE + + + G +D E + ++ ++ + + +I+
Sbjct: 3 YRVTLIPGDGIGPEVTRAMTTVLEASG--VDLEWIRVEAGVEVIEKYGTPLPPQVLESIR 60
Query: 398 RNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQN 577
V +KG I T + S NVA+R ELD+YA + KS PG+ + +DID+V++R+N
Sbjct: 61 ETRVAIKGPIGTPVGTGF-RSVNVAIRKELDLYANLRPAKSLPGIKSPFQDIDLVVVREN 119
Query: 578 TEGEYAMLEHE 610
TE YA +E E
Sbjct: 120 TEDLYAGIEFE 130
>UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1;
Planctomyces maris DSM 8797|Rep: Isocitrate
dehydrogenase, putative - Planctomyces maris DSM 8797
Length = 390
Score = 74.1 bits (174), Expect = 3e-12
Identities = 46/131 (35%), Positives = 71/131 (54%), Gaps = 4/131 (3%)
Frame = +2
Query: 233 HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDID-PTMDNDDDV-QYAITTIKRNG 406
+ VT++PG G+GPE R G ID++V + ++ + V + +I+ N
Sbjct: 2 YKVTLIPGDGVGPEIAEATRKCVDATGVKIDWDVQECGIEVIEAEGGVPDRVMDSIRANK 61
Query: 407 VGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKD--IDVVIIRQNT 580
+ LK I T + S NV LR EL +YA I CK+Y GV T D +D+V++R+NT
Sbjct: 62 IALKAPITTPIGKGF-RSVNVFLRQELGLYACIRPCKTYKGVRTYFADSNVDLVVVRENT 120
Query: 581 EGEYAMLEHES 613
E YA +E ++
Sbjct: 121 EDLYAGVEFQA 131
>UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2;
Bacteria|Rep: Isocitrate dehydrogenase - Gloeobacter
violaceus
Length = 359
Score = 73.7 bits (173), Expect = 4e-12
Identities = 42/129 (32%), Positives = 69/129 (53%), Gaps = 3/129 (2%)
Frame = +2
Query: 233 HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQY---AITTIKRN 403
+ VT++ G GIGPE R + G ++ VVD + I ++ +
Sbjct: 4 YRVTLIRGDGIGPEVTQAARIVLDATGIDFEWVVVDAGAEVMEKSGTPLPAPVIEAVRAS 63
Query: 404 GVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTE 583
+KG I T + + + S NVALR LD+YA + ++ PGV +R+ +ID+V++R+NTE
Sbjct: 64 DAAIKGPITTPAGSG-IRSVNVALRRALDLYANLRPARTLPGVHSRYDNIDLVVVRENTE 122
Query: 584 GEYAMLEHE 610
Y+ +E E
Sbjct: 123 DLYSGIEFE 131
>UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9;
Euteleostomi|Rep: NAD+-isocitrate dehydrogenase - Homo
sapiens (Human)
Length = 133
Score = 73.3 bits (172), Expect = 5e-12
Identities = 36/105 (34%), Positives = 63/105 (60%), Gaps = 3/105 (2%)
Frame = +2
Query: 227 GRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDID--PTMDNDDDVQYAITTIKR 400
G VTMLPG G+GPE M V+++FK P++F+ + M +++ ++ ++++K
Sbjct: 15 GAFPVTMLPGDGVGPELMHAVKEVFKAASVPVEFQEHHLSEVQNMASEEKLEQVLSSMKE 74
Query: 401 NGVGLKGNIETKSE-AAYVTSRNVALRNELDMYAYILNCKSYPGV 532
N V + G I T E + S ++ LR +LD++A +++ KS PGV
Sbjct: 75 NKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVIHVKSLPGV 119
>UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]
subunit-like 4 (Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4); n=1; Arabidopsis thaliana|Rep:
Putative isocitrate dehydrogenase [NAD] subunit-like 4
(Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4) - Arabidopsis thaliana
(Mouse-ear cress)
Length = 294
Score = 71.3 bits (167), Expect = 2e-11
Identities = 46/130 (35%), Positives = 72/130 (55%), Gaps = 1/130 (0%)
Frame = +2
Query: 287 VRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRN 466
V + + AP+ FE I N + + +I++N V L G + S
Sbjct: 16 VHQVMDAMQAPVYFETYIIKGKNMNHLTWE-VVDSIRKNKVCLNGRVNN--------SLC 66
Query: 467 VALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKV- 643
R ELD++A +++C + G +RH+++D+V+IR+NTEGEYA EHE V GV+ES +V
Sbjct: 67 GGARKELDLFASLVDCFNLNGQPSRHENVDIVVIRENTEGEYAGREHEVVPGVIESFQVT 126
Query: 644 VTADNSXRVA 673
+T S R+A
Sbjct: 127 MTKFWSDRIA 136
>UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH).; n=1;
Bos taurus|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH). - Bos Taurus
Length = 260
Score = 68.9 bits (161), Expect = 1e-10
Identities = 31/62 (50%), Positives = 45/62 (72%)
Frame = +2
Query: 488 DMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSXR 667
D+ A ++ +S P V TRHK+ID++++R NTEGEY+ LE ES+N VVES++ VT R
Sbjct: 17 DLCANVVQFESQPRVETRHKNIDILVVRDNTEGEYSNLEDESMNRVVESLRTVTKAKCLR 76
Query: 668 VA 673
+A
Sbjct: 77 LA 78
>UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Thermoprotei|Rep: 3-isopropylmalate dehydrogenase -
Sulfolobus tokodaii
Length = 337
Score = 67.7 bits (158), Expect = 2e-10
Identities = 51/152 (33%), Positives = 78/152 (51%), Gaps = 7/152 (4%)
Frame = +2
Query: 239 VTMLPGGGIGPECMGYVRDIFKYIGA----PIDF-EVVDIDPTMDNDDDV--QYAITTIK 397
V ++ G GIGPE + + I I PI++ EV D + + + ++ I
Sbjct: 5 VALIQGDGIGPEIVSKSKRILAKINELYSLPIEYIEVEAGDRALARYGEALPKDSLKIID 64
Query: 398 RNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQN 577
+ + LKG + AA V V LR DMYA I KS PG+ T++ ++D++I+R+N
Sbjct: 65 KADIILKGPVG--ESAADVV---VKLRQIYDMYANIRPAKSIPGIDTKYGNVDILIVREN 119
Query: 578 TEGEYAMLEHESVNGVVESMKVVTADNSXRVA 673
TE Y EH +GV MK++T S R+A
Sbjct: 120 TEDLYKGFEHIVSDGVAVGMKIITRFASERIA 151
>UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68;
Bacteria|Rep: Isocitrate dehydrogenase -
Janthinobacterium sp. (strain Marseille) (Minibacterium
massiliensis)
Length = 349
Score = 66.9 bits (156), Expect = 4e-10
Identities = 43/127 (33%), Positives = 67/127 (52%), Gaps = 4/127 (3%)
Frame = +2
Query: 239 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDID-PTMDNDDDV--QYAITTIKRNGV 409
VT++PG GIGPE + V +F +G P +E ++ D+ Q + +I R G+
Sbjct: 12 VTLIPGDGIGPEIVDVVVRVFDALGNPFAWETQQAGVNALEKSGDLLPQTTLDSIGRTGL 71
Query: 410 GLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKS-YPGVATRHKDIDVVIIRQNTEG 586
LKG + T + S NV LR +YA + ++ PG R++ ID+V++R+N EG
Sbjct: 72 ALKGPLSTPIGGGF-RSVNVRLRETFQLYANVRPARTIVPG--GRYEKIDLVLVRENLEG 128
Query: 587 EYAMLEH 607
Y EH
Sbjct: 129 LYVGHEH 135
>UniRef50_Q4V533 Cluster: IP13250p; n=4; Drosophila
melanogaster|Rep: IP13250p - Drosophila melanogaster
(Fruit fly)
Length = 475
Score = 66.9 bits (156), Expect = 4e-10
Identities = 40/150 (26%), Positives = 80/150 (53%), Gaps = 1/150 (0%)
Frame = +2
Query: 203 LIPKAQYGGRHAVTMLPGGGI-GPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQY 379
++PK++YGG + V+++ G I G + +V + P++ +V++ DD+ +
Sbjct: 53 VLPKSKYGGINTVSLVTGTTIIGQQGAQFVSSLLSSSRVPVEVQVIEAG----QDDEYFH 108
Query: 380 AITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDV 559
++ RN + + + +EA + + + N+LD+Y + +S+PG R +D+
Sbjct: 109 SVL---RNRTAVHVDNQADAEAK---QKALKICNDLDLYVFKTRTRSFPGFKCRFPGVDI 162
Query: 560 VIIRQNTEGEYAMLEHESVNGVVESMKVVT 649
+I QN G + LE+ V GVVE++ VV+
Sbjct: 163 QLIGQNNMGIFNELEYSPVEGVVEALSVVS 192
>UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1;
Entamoeba histolytica HM-1:IMSS|Rep: tartrate
dehydrogenase - Entamoeba histolytica HM-1:IMSS
Length = 370
Score = 64.9 bits (151), Expect = 2e-09
Identities = 44/153 (28%), Positives = 79/153 (51%), Gaps = 7/153 (4%)
Frame = +2
Query: 230 RHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVD--IDPTMDNDDDVQY-AITTIKR 400
+H + ++PG GIG E M +F+ + PI + VD I + V I +K+
Sbjct: 10 QHKIIVIPGDGIGAEVMNEAEKMFQSLNLPIQRDYVDWGIQHYLKTGKVVPIDYIDQVKQ 69
Query: 401 NGVGLKGNI-ETKSEAAYVTSRN-VALRNELDMYAYILNCKSYPGVATRHK--DIDVVII 568
L G++ + ++ YVT + +R +LD + + K +PG+ T K +IDV+++
Sbjct: 70 YDAILLGSLGDPRTLPDYVTLEPLIQMRQQLDQFLCLRPAKHFPGIPTPLKKCEIDVLVV 129
Query: 569 RQNTEGEYAMLEHESVNGVVESMKVVTADNSXR 667
R+N+EGEY+ + +G E + +A +S R
Sbjct: 130 RENSEGEYSNIGGIFKSGTPEEFAIESAVHSRR 162
>UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanococcus jannaschii
Length = 333
Score = 58.0 bits (134), Expect = 2e-07
Identities = 50/156 (32%), Positives = 73/156 (46%), Gaps = 10/156 (6%)
Frame = +2
Query: 233 HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVG 412
H + ++ G GIG E + + + G P +F + D+V KR G
Sbjct: 2 HKICVIEGDGIGKEVVPATIQVLEATGLPFEFVYAEAG------DEVY------KRTGKA 49
Query: 413 L-KGNIETKSE-------AAYVTSRNVA--LRNELDMYAYILNCKSYPGVATRHKDIDVV 562
L + IET + AA T+ +V LR+ LD YA I K+Y GV DID V
Sbjct: 50 LPEETIETALDCDAVLFGAAGETAADVIVKLRHILDTYANIRPVKAYKGVKCLRPDIDYV 109
Query: 563 IIRQNTEGEYAMLEHESVNGVVESMKVVTADNSXRV 670
I+R+NTEG Y +E E G+ + +V+T R+
Sbjct: 110 IVRENTEGLYKGIEAEIDEGITIATRVITEKACERI 145
>UniRef50_Q2VF40 Cluster: Isocitrate dehydrogenase 3 gamma subunit;
n=1; Pan troglodytes|Rep: Isocitrate dehydrogenase 3
gamma subunit - Pan troglodytes (Chimpanzee)
Length = 165
Score = 57.2 bits (132), Expect = 3e-07
Identities = 24/37 (64%), Positives = 30/37 (81%)
Frame = +2
Query: 209 PKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAP 319
P A+YGGRH VTM+PG GIGPE M +V+ +F+Y GAP
Sbjct: 105 PSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRY-GAP 140
>UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=38; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Synechocystis sp. (strain PCC 6803)
Length = 475
Score = 56.4 bits (130), Expect = 6e-07
Identities = 29/77 (37%), Positives = 43/77 (55%), Gaps = 3/77 (3%)
Frame = +2
Query: 383 ITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHK---DI 553
+T IK GV +KG + T + S NVALR D+Y + C+ YPG + HK +
Sbjct: 89 LTAIKEYGVAIKGPLTTPVGGG-IRSLNVALRQIFDLYTCVRPCRYYPGTPSPHKTPEKL 147
Query: 554 DVVIIRQNTEGEYAMLE 604
D+++ R+NTE Y +E
Sbjct: 148 DIIVYRENTEDIYLGIE 164
>UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanobacterium thermoautotrophicum
Length = 329
Score = 55.6 bits (128), Expect = 1e-06
Identities = 40/145 (27%), Positives = 63/145 (43%)
Frame = +2
Query: 239 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLK 418
+ ++PG GIG E M I + ++F D T++ G
Sbjct: 6 IAVIPGDGIGVEVMEAALHILNTLDLDLEFIHADAGDACLKRTGTALPEETLEAVGEARA 65
Query: 419 GNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAM 598
E+A V LR E D++A + KS PGV + D+D VI+R+NTE Y
Sbjct: 66 TLFGAAGESA--ADVIVRLRREFDLFANLRPVKSLPGVPCLYPDLDFVIVRENTEDLYVG 123
Query: 599 LEHESVNGVVESMKVVTADNSXRVA 673
E + G V + +++T S R++
Sbjct: 124 DEEYTPEGAV-AKRIITRTASRRIS 147
>UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase; n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Isopropylmalate/isohomocitrate dehydrogenase -
Candidatus Nitrosopumilus maritimus SCM1
Length = 337
Score = 53.6 bits (123), Expect = 4e-06
Identities = 43/154 (27%), Positives = 74/154 (48%), Gaps = 7/154 (4%)
Frame = +2
Query: 233 HAVTMLPGGGIGPECMGYVRDIFKYIGAPID--FEVVDI---DPTMDNDDDV--QYAITT 391
+ ++++ G GIGPE + + I +D F + + D ++ ++
Sbjct: 2 YKISLITGDGIGPELSDSAVSVLETIHDKLDLKFGITKLSAGDKALEQTGKALPDDTVSA 61
Query: 392 IKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIR 571
IK++ +K + AA V V LR LD+YA I KSYP + DID+VI+R
Sbjct: 62 IKQSDACMKAPVG--ESAADVI---VVLRRMLDLYANIRPAKSYPHMPALRDDIDMVIVR 116
Query: 572 QNTEGEYAMLEHESVNGVVESMKVVTADNSXRVA 673
+NTE Y E S+ ++++++ S R+A
Sbjct: 117 ENTEDLYTGKEF-SLGDSSVALRIISEQASKRIA 149
>UniRef50_Q5HNL1 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=73; cellular organisms|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Staphylococcus epidermidis (strain ATCC 35984 /
RP62A)
Length = 422
Score = 52.4 bits (120), Expect = 1e-05
Identities = 34/94 (36%), Positives = 52/94 (55%), Gaps = 3/94 (3%)
Frame = +2
Query: 374 QYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT---RH 544
Q + TIK + +KG + T + S NVALR ELD++ + + + GV + R
Sbjct: 76 QETLETIKEYLIAVKGPLTTPIGGG-IRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRP 134
Query: 545 KDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVV 646
+D+D+VI R+NTE YA +E + G E KV+
Sbjct: 135 EDVDMVIFRENTEDIYAGIEFK--QGTSEVKKVI 166
>UniRef50_A5DIP7 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 173
Score = 51.2 bits (117), Expect = 2e-05
Identities = 42/104 (40%), Positives = 52/104 (50%)
Frame = -3
Query: 531 TPG*DLQFSM*AYMSSSFLRATLRDVT*AASLLVSMLPFSPTPFLLMVVIAYWTSSSLSI 352
TPG L + A +S+SFL AT D+ + V+ +PF+PT FL A T LS
Sbjct: 8 TPGMFLIKTNEAKISNSFLNATFNDLP-DDPVGVNKIPFNPTLFLFNDSTASATPVPLS- 65
Query: 351 VGSMSTTSKSIGAPMYLNMSRTYPMHSGPIPPPGSMVTA*RPPY 220
ST S S+G L M T + S PIP PG VT PPY
Sbjct: 66 KPETSTVSHSMGTFSDLKMVLTESVISLPIPSPGMRVTVYLPPY 109
>UniRef50_P41566 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 106
Score = 46.8 bits (106), Expect(2) = 3e-05
Identities = 24/58 (41%), Positives = 30/58 (51%)
Frame = +2
Query: 194 KQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDD 367
+Q + P A+YGG VTM PG G GPE M V P+DFE V + D +D
Sbjct: 3 QQTIPPSAKYGGILTVTMSPGDGDGPELMLTVXXXXXSACVPVDFEEVVVSSNADEED 60
Score = 23.8 bits (49), Expect(2) = 3e-05
Identities = 8/20 (40%), Positives = 14/20 (70%)
Frame = +2
Query: 473 LRNELDMYAYILNCKSYPGV 532
+R LD+YA +++CK G+
Sbjct: 61 IRTSLDLYANVIHCKLGDGL 80
>UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
- Archaeoglobus fulgidus
Length = 326
Score = 50.8 bits (116), Expect = 3e-05
Identities = 38/149 (25%), Positives = 69/149 (46%), Gaps = 4/149 (2%)
Frame = +2
Query: 239 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDI-DPTMDNDDDV--QYAITTIKRNGV 409
+ ++PG GIG E M I + + P ++ D D ++ + +++
Sbjct: 4 IVVIPGDGIGKEVMEAAMLILEKLDLPFEYSYYDAGDEALEKYGKALPDETLEACRKSDA 63
Query: 410 GLKGNI-ETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEG 586
L G ET ++ V LR EL +A + K+ G+ + +D+V++R+NTE
Sbjct: 64 VLFGAAGETAADVI------VRLRRELGTFANVRPAKAIEGIECLYPGLDIVVVRENTEC 117
Query: 587 EYAMLEHESVNGVVESMKVVTADNSXRVA 673
Y E V E+++V+T + S R+A
Sbjct: 118 LYMGFEF-GFGDVTEAIRVITREASERIA 145
>UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Proteobacteria|Rep: 3-isopropylmalate dehydrogenase -
Bradyrhizobium japonicum
Length = 365
Score = 49.6 bits (113), Expect = 7e-05
Identities = 41/151 (27%), Positives = 63/151 (41%), Gaps = 11/151 (7%)
Frame = +2
Query: 203 LIPKAQYGGR-HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQY 379
+ P Q+ G + +LPG GIGPE + + + + + + Q+
Sbjct: 2 IAPALQFWGNVMQLIVLPGDGIGPEITTATSGVLRAASERFQLNLRLEEHAVGHASLKQF 61
Query: 380 AITT------IKRNGVGL----KGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPG 529
T I R GL + K EA + + R LD+YA + ++Y G
Sbjct: 62 GTTVRPELLDIVRGADGLILGPTATFDFKDEAHGEINPSRHFRKNLDLYANVRPARTYAG 121
Query: 530 VATRHKDIDVVIIRQNTEGEYAMLEHESVNG 622
R D D+V++R+NTEG YA E NG
Sbjct: 122 RPGRLGDFDLVVVRENTEGFYADRNMEQGNG 152
>UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;
n=1; Ignicoccus hospitalis KIN4/I|Rep: 3-isopropylmalate
dehydrogenase - Ignicoccus hospitalis KIN4/I
Length = 343
Score = 47.2 bits (107), Expect = 4e-04
Identities = 38/131 (29%), Positives = 64/131 (48%), Gaps = 8/131 (6%)
Frame = +2
Query: 239 VTMLPGGGIGPECMGYVRDIFKYIGA----PIDFEVVDI-DPTMDNDDDV--QYAITTIK 397
V ++ G GIGPE +G + + I P++F V+ D + + + + +
Sbjct: 4 VAVIEGDGIGPEVVGATLKVLEKIRETFKLPLEFVFVEAGDRAKEKYGEALPKESYERLL 63
Query: 398 RNGVGLKGNI-ETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQ 574
R LKG + ET ++ V LR ELD++A I K PGV +++D++I+R+
Sbjct: 64 RADAILKGPVGETAADVI------VRLRRELDLFANIRPAKVLPGVPALKENVDLIIVRE 117
Query: 575 NTEGEYAMLEH 607
N E Y E+
Sbjct: 118 NIEDLYVGAEN 128
>UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Chloroflexi (class)|Rep: 3-isopropylmalate dehydrogenase
- Roseiflexus sp. RS-1
Length = 362
Score = 47.2 bits (107), Expect = 4e-04
Identities = 43/154 (27%), Positives = 68/154 (44%), Gaps = 8/154 (5%)
Frame = +2
Query: 233 HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDI--DPTMDNDDDVQYAITTIKRNG 406
+ + ++PG GIG E + + + G P FE D + + + A T R
Sbjct: 6 YTILVIPGDGIGREVIPAAVAVLRATGLPFHFENADAGWECFQRQGEALPSATLTAARAA 65
Query: 407 VG-LKGNIETKS-EAAYVTSRNVALRNELDMYAYI---LNCKSYPGVATRHKDIDVVIIR 571
L G + + A S V LR ELD+YA I + G R + +D+V++R
Sbjct: 66 DAILFGAVASPGYPVAGYRSPIVRLRRELDLYANIRPVFDDLPENGSNPRRRKVDLVVVR 125
Query: 572 QNTEGEYAMLEHESVNGVVE-SMKVVTADNSXRV 670
+NTE YA E +G + +V+T S R+
Sbjct: 126 ENTEDVYAGRERVEDDGATAIAERVITRRASARI 159
>UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=2; Archaea|Rep: Isocitrate dehydrogenase,
NADP-dependent - Halorubrum lacusprofundi ATCC 49239
Length = 463
Score = 47.2 bits (107), Expect = 4e-04
Identities = 31/95 (32%), Positives = 51/95 (53%), Gaps = 3/95 (3%)
Frame = +2
Query: 383 ITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKD---I 553
++ I+ + V +KG + T A + S NVALR LD+YA + GV + K+ +
Sbjct: 131 VSAIRDHRVAIKGPLTTPVGAGF-RSLNVALRKTLDLYANVRPTYYLDGVPSPVKNPEKM 189
Query: 554 DVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADN 658
D++ R+NTE YA +E E+ VE ++ D+
Sbjct: 190 DMITFRENTEDVYAGIEWEAGTDEVEQVRDFLEDD 224
>UniRef50_A5URE6 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=4; Chloroflexaceae|Rep: Isocitrate dehydrogenase,
NADP-dependent - Roseiflexus sp. RS-1
Length = 453
Score = 46.8 bits (106), Expect = 5e-04
Identities = 31/83 (37%), Positives = 48/83 (57%), Gaps = 3/83 (3%)
Frame = +2
Query: 407 VGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT---RHKDIDVVIIRQN 577
VG+KG + T + S NVALR LD+Y + + + GV + R + +D+VI R+N
Sbjct: 95 VGIKGPLTTPVGRG-IRSLNVALRQLLDLYVCLRPVRYFQGVPSPVKRPELVDMVIFREN 153
Query: 578 TEGEYAMLEHESVNGVVESMKVV 646
TE YA +E+ + G E+ KV+
Sbjct: 154 TEDIYAGIEYAA--GTPEAQKVL 174
>UniRef50_A7T3D9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 419
Score = 46.4 bits (105), Expect = 6e-04
Identities = 31/94 (32%), Positives = 51/94 (54%), Gaps = 3/94 (3%)
Frame = +2
Query: 374 QYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHK-- 547
Q + +K V +KG + T + S NVALR +LD+Y + + + GV + K
Sbjct: 88 QETLDAVKDYVVSIKGPLTTPVGGG-IRSLNVALRQQLDLYVCLRPVRWFEGVPSPVKKP 146
Query: 548 -DIDVVIIRQNTEGEYAMLEHESVNGVVESMKVV 646
D+D+ I R+N+E YA +E ++ G E+ KV+
Sbjct: 147 GDVDMTIFRENSEDIYAGIEWKA--GSPEATKVI 178
>UniRef50_Q0W1Q6 Cluster: 2-isopropylmalate dehydrogenase; n=5;
Euryarchaeota|Rep: 2-isopropylmalate dehydrogenase -
Uncultured methanogenic archaeon RC-I
Length = 324
Score = 46.0 bits (104), Expect = 8e-04
Identities = 42/148 (28%), Positives = 69/148 (46%), Gaps = 3/148 (2%)
Frame = +2
Query: 239 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYA---ITTIKRNGV 409
+ +LPG GIG E + ++ K +F V++ + V + + T+K
Sbjct: 3 IAVLPGDGIGREVVPVAHEVLKVALPDAEFLHVEVGNERYVREGVSMSPADLETVKACDC 62
Query: 410 GLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGE 589
L G I + Y S + LR ELD+YA I +S P ++ R ++ I R+N+E
Sbjct: 63 VLFGAITSPPGKPY-RSIILTLRKELDLYANIRPFRSCP-ISPR--KVNFTIYRENSEDL 118
Query: 590 YAMLEHESVNGVVESMKVVTADNSXRVA 673
Y +E E S++V+T S R+A
Sbjct: 119 YMGIE-EITGDEARSVRVITRKASERIA 145
>UniRef50_Q0X0C1 Cluster: Putative dehydrogenase; n=1; Streptomyces
lasaliensis|Rep: Putative dehydrogenase - Streptomyces
lasaliensis
Length = 362
Score = 44.0 bits (99), Expect = 0.003
Identities = 45/165 (27%), Positives = 75/165 (45%), Gaps = 14/165 (8%)
Frame = +2
Query: 215 AQYGGRHAVT---MLPGGGIGPECMGYVRDIFKYIGAPIDFEVVD---IDPTMDNDDDVQ 376
A+ G AVT ++PG GIGPE + D+ +G +++D D + + +
Sbjct: 11 ARAGSETAVTTIAVIPGDGIGPEVIEPALDVLDALGLGTRTDILDHVNADTYLRTGEALT 70
Query: 377 YA-ITTIKRNGVGLKGNIETK--SEAAYVTSRNVALRNELDMY-----AYILNCKSYPGV 532
+ + I+ + L G + + +YV LR ELD+Y A + + + P
Sbjct: 71 GSDLDRIRSSEAALLGAVGDPRLGDTSYVRGVLTTLRLELDLYVNYRPARLWHDRLSPLR 130
Query: 533 ATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSXR 667
+ ID VI+R+NTEG Y+ + + G E + V D S R
Sbjct: 131 DPARRAIDCVIVRENTEGLYSGIGGGARTGTPEEI-AVDVDLSTR 174
>UniRef50_A5DIP6 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 230
Score = 43.6 bits (98), Expect = 0.004
Identities = 23/61 (37%), Positives = 32/61 (52%)
Frame = -2
Query: 646 HHFH*LDHTIHGFVFQHSVFTFCVLSDNNNINVLMSGRNARVRFTVQYVSIHVQFVSESH 467
H H L+HT VFQ +FTF V SD +N L + +A F S ++QF S+ +
Sbjct: 74 HDLHRLNHTRVRLVFQSRIFTFSVFSDEGKVNALQTRLDAGNVFDQDQRSKNIQFFSQRN 133
Query: 466 I 464
I
Sbjct: 134 I 134
>UniRef50_Q9CKK6 Cluster: Idp; n=2; Pasteurellaceae|Rep: Idp -
Pasteurella multocida
Length = 415
Score = 42.7 bits (96), Expect = 0.008
Identities = 31/91 (34%), Positives = 50/91 (54%), Gaps = 3/91 (3%)
Frame = +2
Query: 383 ITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT--RHKD-I 553
+T I+ V +KG + T + S NVA+R LD+Y + + Y G + +H + +
Sbjct: 89 MTFIRDYHVAIKGPLMTPVGGG-IRSLNVAMRQGLDLYNCLRPIRYYDGTPSPVKHPELV 147
Query: 554 DVVIIRQNTEGEYAMLEHESVNGVVESMKVV 646
D+VI R+N+E YA +E V G E+ KV+
Sbjct: 148 DMVIFRENSEDIYAGVEW--VAGSAEANKVI 176
>UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenase
family protein; n=6; Archaea|Rep:
Isocitrate/isopropylmalate dehydrogenase family protein
- Methanosarcina acetivorans
Length = 342
Score = 42.7 bits (96), Expect = 0.008
Identities = 30/148 (20%), Positives = 64/148 (43%), Gaps = 5/148 (3%)
Frame = +2
Query: 245 MLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITT-----IKRNGV 409
++ G G+GPE + + + G ++F + + + + + +
Sbjct: 7 VIKGDGVGPELVEAMLKVANAAGTDVEFVMCEAGAGWWEEHGGNSLVPDETWQILDSSDA 66
Query: 410 GLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGE 589
KG T S V++R + D+YA + K++P D+++V +R+ TEG
Sbjct: 67 CFKGPTTTPGGIGSPRSVAVSIRRKYDLYANVRPIKTFPNSNAPLGDVEMVCVREGTEGL 126
Query: 590 YAMLEHESVNGVVESMKVVTADNSXRVA 673
Y E + + V +++ +T S ++A
Sbjct: 127 YIGEEIQLTDDVSIAIRKITRTASGKIA 154
>UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Methanosaeta thermophila PT|Rep: Isocitrate
dehydrogenase (NAD(+)) - Methanosaeta thermophila
(strain DSM 6194 / PT) (Methanothrixthermophila (strain
DSM 6194 / PT))
Length = 375
Score = 42.7 bits (96), Expect = 0.008
Identities = 32/102 (31%), Positives = 50/102 (49%), Gaps = 5/102 (4%)
Frame = +2
Query: 380 AITTIKRNGVGLKGNIETKSEA---AYVTSRNVALRNELDMYAYILNCKSYPGVATRHKD 550
A+ +K+ V LKG + T + + S NVA+R ELD++A + V+ +
Sbjct: 75 ALDALKKCHVILKGPLTTPKKGDPWPNLESANVAMRRELDLFANVRP------VSIPSEG 128
Query: 551 IDVVIIRQNTEGEYAM--LEHESVNGVVESMKVVTADNSXRV 670
ID V R+NTEGEY + + + KV+T S R+
Sbjct: 129 IDWVFFRENTEGEYVLGSKGFNVTDDLAVDFKVITTQGSERI 170
>UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodococcus sp. (strain RHA1)
Length = 365
Score = 42.3 bits (95), Expect = 0.010
Identities = 19/41 (46%), Positives = 28/41 (68%)
Frame = +2
Query: 473 LRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYA 595
+R D++A I +S GVA+ D+D+VI+R+NTEG YA
Sbjct: 102 VRKRFDLFANIRPARSLEGVASTVPDMDLVIVRENTEGLYA 142
>UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=504; root|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Helicobacter pylori (Campylobacter pylori)
Length = 425
Score = 42.3 bits (95), Expect = 0.010
Identities = 28/90 (31%), Positives = 46/90 (51%), Gaps = 2/90 (2%)
Frame = +2
Query: 383 ITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSY--PGVATRHKDID 556
I I V +KG + T + S NVALR ++D+Y + + Y P + +D
Sbjct: 99 IEAINHYKVSIKGPLTTPIGEGF-RSLNVALRQKMDLYVCLRPVRWYGSPSPVKEPQKVD 157
Query: 557 VVIIRQNTEGEYAMLEHESVNGVVESMKVV 646
+VI R+N+E YA +E + G E+ K++
Sbjct: 158 MVIFRENSEDIYAGIEWQ--EGSAEAKKLI 185
>UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2;
Alphaproteobacteria|Rep: Isopropylmalate dehydrogenase -
Oceanicola granulosus HTCC2516
Length = 363
Score = 41.9 bits (94), Expect = 0.014
Identities = 17/38 (44%), Positives = 25/38 (65%)
Frame = +2
Query: 473 LRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEG 586
LR D++A + +SYPG+ DID+VI+R+N EG
Sbjct: 95 LRKGFDLFANVRPTRSYPGIGCLFDDIDLVIVRENNEG 132
>UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase,
mitochondrial precursor; n=33; Dikarya|Rep:
Homoisocitrate dehydrogenase, mitochondrial precursor -
Saccharomyces cerevisiae (Baker's yeast)
Length = 371
Score = 41.9 bits (94), Expect = 0.014
Identities = 34/131 (25%), Positives = 64/131 (48%), Gaps = 9/131 (6%)
Frame = +2
Query: 239 VTMLPGGGIGPECMGYVRDIFKYIGAP--IDFEVVDIDPTMDNDDDVQYA-----ITTIK 397
+ ++PG GIG E + + + + + + + F +D+ + A + +K
Sbjct: 26 IGLIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFIDLYAGFQTFQETGKALPDETVKVLK 85
Query: 398 RNGVG-LKGNIETKS-EAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIR 571
G L G +++ + + +S VALR E+ ++A + KS G + K ID+VI+R
Sbjct: 86 EQCQGALFGAVQSPTTKVEGYSSPIVALRREMGLFANVRPVKSVEG--EKGKPIDMVIVR 143
Query: 572 QNTEGEYAMLE 604
+NTE Y +E
Sbjct: 144 ENTEDLYIKIE 154
>UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Thermoproteaceae|Rep: 3-isopropylmalate dehydrogenase -
Pyrobaculum aerophilum
Length = 290
Score = 41.5 bits (93), Expect = 0.018
Identities = 28/78 (35%), Positives = 43/78 (55%)
Frame = +2
Query: 440 EAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVN 619
E+AY + + +R L YA I K+ PGV ++ID V +R+N E Y E++ V
Sbjct: 41 ESAYDVTSLIRMRYTL--YANIRPVKNLPGVPAV-REIDCVFVRENVEDVYVGAEYK-VG 96
Query: 620 GVVESMKVVTADNSXRVA 673
V ++KV+T + RVA
Sbjct: 97 DVAIALKVITEKGTRRVA 114
>UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;
n=4; Thermococcaceae|Rep: LeuB-2 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 346
Score = 40.7 bits (91), Expect = 0.032
Identities = 41/154 (26%), Positives = 70/154 (45%), Gaps = 7/154 (4%)
Frame = +2
Query: 233 HAVTMLPGGGIGPECM-------GYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITT 391
+ V ++ G GIGPE + V D ++ FEV + ++DD++
Sbjct: 2 YRVAVIKGDGIGPEVVDSAIRVVNSVTDRIRFYEFEGGFEVFKRIGSPISEDDLK----E 57
Query: 392 IKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIR 571
I++ L G T S V LR ELD+YA N + P ++ ++VI+R
Sbjct: 58 IRKMDAILFGATTTPFNVPGYRSLIVTLRKELDLYA---NLRIIPDLSNGK---EIVIVR 111
Query: 572 QNTEGEYAMLEHESVNGVVESMKVVTADNSXRVA 673
+NTEG YA + + +++T + + R+A
Sbjct: 112 ENTEGLYAR-DGIGFSDRAIDFRIITLEGARRIA 144
>UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase;
n=106; Bacteria|Rep: Tartrate
dehydrogenase/decarboxylase - Pseudomonas putida
Length = 365
Score = 39.5 bits (88), Expect = 0.073
Identities = 22/47 (46%), Positives = 28/47 (59%), Gaps = 5/47 (10%)
Frame = +2
Query: 476 RNELDMYAYILNCKSYPGV----ATRHK-DIDVVIIRQNTEGEYAML 601
R E D Y I + +PGV A R DID V++R+NTEGEY+ L
Sbjct: 98 RREFDQYVNIRPVRLFPGVPCALANRKVGDIDFVVVRENTEGEYSSL 144
>UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for
NADP+; n=3; Alteromonadales|Rep: Isocitrate
dehydrogenase, specific for NADP+ - Alteromonadales
bacterium TW-7
Length = 422
Score = 38.3 bits (85), Expect = 0.17
Identities = 25/100 (25%), Positives = 52/100 (52%), Gaps = 3/100 (3%)
Frame = +2
Query: 356 DNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVA 535
D D Q I ++ + +KG + T + S NVALR E+D++ + K + +
Sbjct: 81 DGDWFPQETIQAVRACKIAIKGPLTTPLGGGF-RSLNVALRQEMDLFVNMRTIKGFSALP 139
Query: 536 TRHKD---IDVVIIRQNTEGEYAMLEHESVNGVVESMKVV 646
+ K+ ++ ++R ++E Y+ +E ++ G +ES K++
Sbjct: 140 SPLKNPFLTNITVLRDSSEDVYSGIEWQA--GSIESEKML 177
>UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep: Isocitrate
dehydrogenase (NAD(+)) - Candidatus Nitrosopumilus
maritimus SCM1
Length = 343
Score = 37.9 bits (84), Expect = 0.22
Identities = 34/149 (22%), Positives = 61/149 (40%), Gaps = 7/149 (4%)
Frame = +2
Query: 245 MLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTM---DNDDDVQY----AITTIKRN 403
++ G GIGPE + + + K + + + + D Y + ++
Sbjct: 7 VMKGDGIGPEVVDSMLRVLKECNFQSELILCEAGSEQWDKNGRKDASYIPDVTMKILEET 66
Query: 404 GVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTE 583
KG T S V LR + D+YA I K+Y + T + +D V R+ TE
Sbjct: 67 DCCFKGPTTTIPVPGAPRSVAVTLRQKFDLYANIRPTKTYDRL-TPDRKLDCVCFREATE 125
Query: 584 GEYAMLEHESVNGVVESMKVVTADNSXRV 670
G Y +E + + +++ +T S R+
Sbjct: 126 GLYTGVEAKITDDAAIAIRKITRQGSRRL 154
>UniRef50_A6G3V7 Cluster: Probable 3-isopropylmalate dehydrogenase;
n=1; Plesiocystis pacifica SIR-1|Rep: Probable
3-isopropylmalate dehydrogenase - Plesiocystis pacifica
SIR-1
Length = 368
Score = 37.1 bits (82), Expect = 0.39
Identities = 28/72 (38%), Positives = 35/72 (48%), Gaps = 10/72 (13%)
Frame = +2
Query: 410 GLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATR----HKDI------DV 559
G G + K S + R L++YA + K YPGV R HK I D+
Sbjct: 65 GTGGPVLMKDNKMAGFSPVIGNRMRLNLYANVRPIKLYPGVQHRIHGGHKQIWEAGKVDM 124
Query: 560 VIIRQNTEGEYA 595
VIIR+NTEG YA
Sbjct: 125 VIIRENTEGLYA 136
>UniRef50_Q9RTT2 Cluster: Isocitrate dehydrogenase, putative; n=2;
Deinococcus|Rep: Isocitrate dehydrogenase, putative -
Deinococcus radiodurans
Length = 333
Score = 36.7 bits (81), Expect = 0.51
Identities = 20/66 (30%), Positives = 38/66 (57%)
Frame = +2
Query: 473 LRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTA 652
LR + ++YA + K+ P V ++++D+VI+R+NT+G Y E + + V+T
Sbjct: 89 LRQKYNLYANVRPTKTRP-VPHSYENVDLVIVRENTQGLYVEQERRYGDTAIAD-TVITR 146
Query: 653 DNSXRV 670
+ S R+
Sbjct: 147 EASDRI 152
>UniRef50_A1SM34 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Nocardioides sp. JS614|Rep: 3-isopropylmalate
dehydrogenase - Nocardioides sp. (strain BAA-499 /
JS614)
Length = 478
Score = 36.7 bits (81), Expect = 0.51
Identities = 37/137 (27%), Positives = 54/137 (39%), Gaps = 15/137 (10%)
Frame = +2
Query: 227 GRHAVTMLPGGGIGPECMGYVRDIFKYIG-APIDFEVVDIDPTMDN--------DDDVQY 379
G + ++PG GIGPE + + A + FE D + D V
Sbjct: 130 GSLRLAVIPGDGIGPEVTAEALKVLEVASPAGVKFEQTRYDLGAERYLATGEVLPDSVLE 189
Query: 380 AIT---TIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT---R 541
I I VG K N + LR ELD Y + + +PGVA+
Sbjct: 190 EIREHDAILLGAVGGKPNDPNLPPGILERGLLLRLRFELDHYVNLRPSRIFPGVASPLAN 249
Query: 542 HKDIDVVIIRQNTEGEY 592
++D V++R+ TEG Y
Sbjct: 250 PGEVDFVVVREGTEGPY 266
>UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: LeuB
protein - Bradyrhizobium japonicum
Length = 359
Score = 36.3 bits (80), Expect = 0.68
Identities = 20/46 (43%), Positives = 29/46 (63%), Gaps = 3/46 (6%)
Frame = +2
Query: 467 VALRNELDMYAYILNCKSYPGVAT---RHKDIDVVIIRQNTEGEYA 595
+ LR +LD++A + K Y GV + R ID VI+R+N+EG YA
Sbjct: 93 LTLRFKLDLFANVRPIKLYKGVPSPLGRPGPIDYVIVRENSEGLYA 138
>UniRef50_P56471 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 90
Score = 36.3 bits (80), Expect = 0.68
Identities = 18/37 (48%), Positives = 20/37 (54%)
Frame = +2
Query: 224 GGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEV 334
GG VT++PG GIGPE V IF API V
Sbjct: 2 GGVKTVTLIPGDGIGPEISAAVMKIFDAAKAPIQANV 38
>UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular
organisms|Rep: Tartrate dehydrogenase - Burkholderia
mallei (Pseudomonas mallei)
Length = 361
Score = 35.5 bits (78), Expect = 1.2
Identities = 34/137 (24%), Positives = 59/137 (43%), Gaps = 16/137 (11%)
Frame = +2
Query: 233 HAVTMLPGGGIG----PECMGYVRDIFKYIGA-----PIDFEVVDIDPTMDN--DDDVQY 379
+ + ++PG GIG PE + + + + G PI++ D DD +
Sbjct: 6 YRIAVIPGDGIGVEVMPEGLRALDAVSRRFGLRFAYEPIEWASCDYYAKHGQMMPDDWKT 65
Query: 380 AITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGV-----ATRH 544
++ + G G ET + + + R E D Y + + + GV +
Sbjct: 66 QLSGMDALLFGAVGWPETVPDHISLWGSLIKFRREFDQYVNLRPARLFDGVPCPLAGRKA 125
Query: 545 KDIDVVIIRQNTEGEYA 595
DID +I+R+NTEGEY+
Sbjct: 126 GDIDFMIVRENTEGEYS 142
>UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Saccharopolyspora erythraea NRRL 2338|Rep:
3-isopropylmalate dehydrogenase - Saccharopolyspora
erythraea (strain NRRL 23338)
Length = 407
Score = 35.5 bits (78), Expect = 1.2
Identities = 37/132 (28%), Positives = 57/132 (43%), Gaps = 14/132 (10%)
Frame = +2
Query: 239 VTMLPGGGIGPECMGYVRDIFKYI-GAPIDFEVVDIDPTMDNDDDVQYAIT--TIKR--- 400
+ ++PG GIGPE + ++ + G ++ D D A++ T++R
Sbjct: 9 IAVIPGDGIGPELVRSAVEVLRAAAGRDVELRFTSEDAGADAFRRTGSAMSAATLERIRT 68
Query: 401 --NGVGLKGNIETKS----EAAYVTSRNVALRNELDMYAYILNCKSYPGVAT--RHKDID 556
+GV LKG + + LR LD YA + PGV R +D
Sbjct: 69 RYHGV-LKGPVGLPGVRHPDGTEAGLLGGVLRGGLDTYANVRPIALLPGVDAPLRGTAVD 127
Query: 557 VVIIRQNTEGEY 592
VI+R+NTEG Y
Sbjct: 128 YVIVRENTEGLY 139
>UniRef50_A6PN62 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Victivallis vadensis ATCC BAA-548|Rep: 3-isopropylmalate
dehydrogenase - Victivallis vadensis ATCC BAA-548
Length = 369
Score = 35.1 bits (77), Expect = 1.6
Identities = 35/137 (25%), Positives = 54/137 (39%), Gaps = 17/137 (12%)
Frame = +2
Query: 233 HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAIT-------- 388
+ + +LPG G GPE + + G F + N Y T
Sbjct: 5 YKIAVLPGDGTGPEVIAEAVKVLDAAGRKFGFTT---EKEYYNWGGAHYLATGETLPADA 61
Query: 389 --TIKRNGVGLKGNIETKSEAAYVTSRNVAL--RNELDMYAYILNCKSYPGVAT-----R 541
+ R+ L G I V + + L R +LD Y + K +PGV T +
Sbjct: 62 KEQLARHDAVLLGAIGHPDVKPGVLEKGILLKLRFDLDQYINLRPVKLFPGVETPLANKK 121
Query: 542 HKDIDVVIIRQNTEGEY 592
+DID V++R+N+ G Y
Sbjct: 122 PEDIDYVVVRENSGGVY 138
>UniRef50_A5UWW1 Cluster: Agmatine deiminase; n=9; cellular
organisms|Rep: Agmatine deiminase - Roseiflexus sp. RS-1
Length = 348
Score = 35.1 bits (77), Expect = 1.6
Identities = 20/74 (27%), Positives = 36/74 (48%)
Frame = +2
Query: 179 PPVIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMD 358
P + R+Q Y G + L G +G + G++ D+ +++ VV+ DPT +
Sbjct: 183 PHLTREQIEQRLCDYLGVSNILWLGDGIVGDDTDGHIDDLARFVAPDTVVTVVESDPTDE 242
Query: 359 NDDDVQYAITTIKR 400
N D +Q + +KR
Sbjct: 243 NYDALQENLRRLKR 256
>UniRef50_A0E5I0 Cluster: Chromosome undetermined scaffold_8, whole
genome shotgun sequence; n=1; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_8,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 293
Score = 34.7 bits (76), Expect = 2.1
Identities = 29/104 (27%), Positives = 48/104 (46%), Gaps = 8/104 (7%)
Frame = +2
Query: 353 MDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRN------ELDMYAYILNC 514
M N D Y I ++ +GL +IE S +++ N+ L+N + +L+C
Sbjct: 1 MQNCDLNSYQIGLSRKQQLGLYSDIEYSSSRYSLSTNNLNLKNLQNLKNRISQLQSVLSC 60
Query: 515 KSYPGVATRHKDIDVVIIRQNTEGEYAMLEHE--SVNGVVESMK 640
K G TR K +D N + Y++ EH+ +N +SMK
Sbjct: 61 KYRKGSLTRSK-LDDSTNLTNDKSTYSLQEHKYNFINFPQQSMK 103
>UniRef50_Q6L2P9 Cluster: Isocitrate dehydrogenase [NADP]; n=2;
Thermoplasmatales|Rep: Isocitrate dehydrogenase [NADP] -
Picrophilus torridus
Length = 392
Score = 34.7 bits (76), Expect = 2.1
Identities = 36/123 (29%), Positives = 55/123 (44%), Gaps = 10/123 (8%)
Frame = +2
Query: 254 GGGIGPECMGYVRDIFKYIGA----PIDFEVV---DIDPTMDNDDDVQYAITTIKRNGVG 412
G GIGPE M R + A I ++ + D + D + +I I V
Sbjct: 24 GDGIGPEIMDATRKVVDAATAMEKKSIAWKEILLGDRAEELKGDRFPEESIKAINDYRVL 83
Query: 413 LKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKD---IDVVIIRQNTE 583
LK + T + S NV +R LD+YA I K PG+ + K+ +++ I R+NT+
Sbjct: 84 LKAPLNTPVGKGF-KSINVRIRMLLDLYANIRPVKFMPGLESPLKNPEKVNLTIFRENTD 142
Query: 584 GEY 592
Y
Sbjct: 143 DLY 145
>UniRef50_A3Y262 Cluster: Phosphorelay protein; n=4;
Vibrionales|Rep: Phosphorelay protein - Vibrio sp.
MED222
Length = 114
Score = 34.3 bits (75), Expect = 2.7
Identities = 12/27 (44%), Positives = 21/27 (77%)
Frame = -2
Query: 334 HFEVNRSTDVFEYVANVSHALRTDTAS 254
H E+N+ +D +Y+A++SHAL++ AS
Sbjct: 39 HLELNKESDTSKYLADISHALKSSAAS 65
>UniRef50_P35484 Cluster: Dihydrolipoyl dehydrogenase; n=3;
Acholeplasmataceae|Rep: Dihydrolipoyl dehydrogenase -
Acholeplasma laidlawii
Length = 336
Score = 34.3 bits (75), Expect = 2.7
Identities = 31/105 (29%), Positives = 50/105 (47%), Gaps = 2/105 (1%)
Frame = +2
Query: 128 SSKAAPATLSDFDVQHKPPVIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKY 307
SS P + K V+ ++L+ Y ++ ++ GG IG E +F
Sbjct: 141 SSAVVPPIPGVKEAYEKGIVVTSRELLNVKNYP--KSIVIVGGGVIGVE----FATVFNS 194
Query: 308 IGAPIDF-EVVD-IDPTMDNDDDVQYAITTIKRNGVGLKGNIETK 436
G+ + E++D I PTMD+D V YA T+KR+G+ + E K
Sbjct: 195 FGSKVTIIEMMDGILPTMDDDIRVAYA-KTLKRDGIEILTKAEVK 238
>UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2;
Bacillaceae|Rep: Tartrate dehydrogenase - Bacillus sp.
B14905
Length = 362
Score = 33.9 bits (74), Expect = 3.6
Identities = 17/44 (38%), Positives = 23/44 (52%), Gaps = 3/44 (6%)
Frame = +2
Query: 473 LRNELDMYAYILNCKSYPGVATR---HKDIDVVIIRQNTEGEYA 595
+R Y KS PG+++ DID VI R+N EGEY+
Sbjct: 94 IRKNFQQYVNFRPIKSLPGISSPLAGGNDIDFVIFRENAEGEYS 137
>UniRef50_Q6C705 Cluster: Similar to DEHA0E18414g Debaryomyces
hansenii; n=1; Yarrowia lipolytica|Rep: Similar to
DEHA0E18414g Debaryomyces hansenii - Yarrowia lipolytica
(Candida lipolytica)
Length = 383
Score = 33.9 bits (74), Expect = 3.6
Identities = 25/74 (33%), Positives = 41/74 (55%), Gaps = 3/74 (4%)
Frame = +2
Query: 461 RNVALRNELDMY---AYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVE 631
+ ++LR ++ Y A+I K GVAT HK+I V ++Q + Y ++ ES N ++
Sbjct: 241 QKLSLREHVESYLNEAHIYVDKK--GVATTHKEITVSSLQQIKDTPYLLVNVESTNAII- 297
Query: 632 SMKVVTADNSXRVA 673
+K+V DN VA
Sbjct: 298 VLKIV--DNKLEVA 309
>UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;
n=4; cellular organisms|Rep: LeuB-1 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 354
Score = 33.9 bits (74), Expect = 3.6
Identities = 35/131 (26%), Positives = 57/131 (43%), Gaps = 12/131 (9%)
Frame = +2
Query: 239 VTMLPGGGIGPECMGYVRDIFKYIG--APIDFEVVDI----DPTMDNDDDV-QYAITTIK 397
+ ++PG GIG E + + K + + + FE + + + + + +AI K
Sbjct: 5 IAVIPGDGIGKEVVAEGLKVLKKLEELSRVSFEFKEYPFGAEHYLKTGETLPDWAIEEFK 64
Query: 398 RNGVGLKGNIETKSEAAYVTSRNVAL--RNELDMYAYILNCKSYPGVATRHKD---IDVV 562
+ G I + R + L R ELD+Y + K Y T K ID+V
Sbjct: 65 KFDAIYFGAIGDPRVKPGILERGILLKMRFELDLYVNLRPVKLYHPRLTPLKGKNKIDIV 124
Query: 563 IIRQNTEGEYA 595
+R+NTEG YA
Sbjct: 125 FVRENTEGLYA 135
>UniRef50_A3W960 Cluster: SCO1/SenC family protein; n=2;
Roseovarius|Rep: SCO1/SenC family protein - Roseovarius
sp. 217
Length = 217
Score = 33.5 bits (73), Expect = 4.8
Identities = 18/56 (32%), Positives = 29/56 (51%)
Frame = +2
Query: 278 MGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEA 445
M ++ + G + ++ IDP +D + + A+T I + VGL GN E SEA
Sbjct: 90 MADAAEVLERRGISVSPVLITIDPVLDTVETMGPALTKISADLVGLTGNREALSEA 145
>UniRef50_Q8IC48 Cluster: Putative uncharacterized protein
PF07_0004; n=1; Plasmodium falciparum 3D7|Rep: Putative
uncharacterized protein PF07_0004 - Plasmodium
falciparum (isolate 3D7)
Length = 964
Score = 33.5 bits (73), Expect = 4.8
Identities = 22/81 (27%), Positives = 39/81 (48%), Gaps = 2/81 (2%)
Frame = +2
Query: 320 IDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNE-LDMY 496
I++E+++++ D+D+DV+Y + I+ + +E K E N L+ E L+
Sbjct: 172 IEYEIIEVEVDDDDDEDVEYEVIEIEVDDDEEVELLEDKEEKIEEVKENKQLKVESLEKK 231
Query: 497 AY-ILNCKSYPGVATRHKDID 556
I YP V K+ID
Sbjct: 232 PLEIKTTPKYPFVTDEQKEID 252
>UniRef50_UPI000065D57A Cluster: Putative polypeptide
N-acetylgalactosaminyltransferase-like protein 3 (EC
2.4.1.41) (Protein-UDP
acetylgalactosaminyltransferase-like protein 3)
(UDP-GalNAc:polypeptide
N-acetylgalactosaminyltransferase- like protein 3)
(Polypeptide GalNAc transferase-lik; n=1; Takifugu
rubripes|Rep: Putative polypeptide
N-acetylgalactosaminyltransferase-like protein 3 (EC
2.4.1.41) (Protein-UDP
acetylgalactosaminyltransferase-like protein 3)
(UDP-GalNAc:polypeptide
N-acetylgalactosaminyltransferase- like protein 3)
(Polypeptide GalNAc transferase-lik - Takifugu rubripes
Length = 605
Score = 32.7 bits (71), Expect = 8.4
Identities = 20/59 (33%), Positives = 29/59 (49%)
Frame = +3
Query: 300 SNTSVLLLTSKWWTLTQRWTMMMMSNML*RPLRGTVWG*RATLKPKVRQPM*RHAMWLS 476
S+ V +LTS W +T+ M+MSN L R W R LK R P+ +W++
Sbjct: 115 SSYGVAILTSAWLKVTEEKKKMLMSNFLKR----LTWPFRECLKTLKRLPLCTWIIWMN 169
>UniRef50_Q08KN2 Cluster: FIg-Hepta; n=3; Takifugu rubripes|Rep:
FIg-Hepta - Fugu rubripes (Japanese pufferfish)
(Takifugu rubripes)
Length = 1678
Score = 32.7 bits (71), Expect = 8.4
Identities = 27/126 (21%), Positives = 52/126 (41%)
Frame = -3
Query: 663 SELSAVTTFIDSTTPFTDSCSNIAYSPSVFCLIITTSMSLCLVATPG*DLQFSM*AYMSS 484
++L+ T + STTPFT+S + + F ++ T+ +L + ++ + +S
Sbjct: 522 TDLNTTTPPVSSTTPFTNSTPPTDLNNTTFTTVVVTNSTLTSATSLNTTIKANRTTATTS 581
Query: 483 SFLRATLRDVT*AASLLVSMLPFSPTPFLLMVVIAYWTSSSLSIVGSMSTTSKSIGAPMY 304
+ AT T A + + S T T+S+ + + +TTS + A
Sbjct: 582 ATTAATTSATTEATTSATTSATTSATTSATTSATTEETTSATTSATTSATTSATTSATTE 641
Query: 303 LNMSRT 286
S T
Sbjct: 642 ATTSAT 647
>UniRef50_Q67N12 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Symbiobacterium thermophilum
Length = 357
Score = 32.7 bits (71), Expect = 8.4
Identities = 24/85 (28%), Positives = 33/85 (38%), Gaps = 1/85 (1%)
Frame = +2
Query: 371 VQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT-RHK 547
V A ++ +G GLK T V S N LR E+D + + PGV T
Sbjct: 56 VYEAAAAMREHGYGLKAATITPEGRGDVGSPNAILRREIDGTVILRTGRPLPGVETIGGI 115
Query: 548 DIDVVIIRQNTEGEYAMLEHESVNG 622
+ ++R TE Y E G
Sbjct: 116 TAPIAVVRMATEDAYEAKEWREGEG 140
>UniRef50_A4C445 Cluster: VCBS; n=1; Pseudoalteromonas tunicata
D2|Rep: VCBS - Pseudoalteromonas tunicata D2
Length = 1600
Score = 32.7 bits (71), Expect = 8.4
Identities = 18/66 (27%), Positives = 29/66 (43%), Gaps = 2/66 (3%)
Frame = +2
Query: 149 TLSDFDVQHKPPVIRKQKLI--PKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPI 322
T+++ QH ++ +L+ P+A Y G +T G G GYV K + A I
Sbjct: 1330 TVTNISAQHGTVTLQNGQLVYTPQASYSGADEITYTVSDGKGGSAQGYVEVTIKPVNATI 1389
Query: 323 DFEVVD 340
V+
Sbjct: 1390 SLIAVN 1395
>UniRef50_A0P1S6 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Rhodobacterales|Rep: 3-isopropylmalate dehydrogenase -
Stappia aggregata IAM 12614
Length = 369
Score = 32.7 bits (71), Expect = 8.4
Identities = 18/48 (37%), Positives = 28/48 (58%), Gaps = 5/48 (10%)
Frame = +2
Query: 458 SRNVALRNELDMYAYILNCKSYPGVATRHKD-----IDVVIIRQNTEG 586
S ++ LR+ +YA + K+YP R D ID+VI+R++TEG
Sbjct: 87 SPHLRLRDRFGLYAGVRPVKAYPNAPQRLADPRAAGIDLVILRESTEG 134
>UniRef50_O14122 Cluster: Cullin-4; n=1; Schizosaccharomyces
pombe|Rep: Cullin-4 - Schizosaccharomyces pombe (Fission
yeast)
Length = 734
Score = 32.7 bits (71), Expect = 8.4
Identities = 16/51 (31%), Positives = 27/51 (52%)
Frame = +2
Query: 353 MDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYI 505
M +DD VQY I +K G+ L +++T E + + R + D+Y Y+
Sbjct: 685 MKHDDLVQYVINNVKDRGIPLVSDVKTAIEK--LLEKEYLEREDNDIYTYV 733
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 696,530,446
Number of Sequences: 1657284
Number of extensions: 14700685
Number of successful extensions: 43442
Number of sequences better than 10.0: 87
Number of HSP's better than 10.0 without gapping: 41652
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 43377
length of database: 575,637,011
effective HSP length: 98
effective length of database: 413,223,179
effective search space used: 52066120554
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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