Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fcaL-P15_F_I08
(843 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_UPI00015B5B0C Cluster: PREDICTED: similar to conserved ... 120 5e-26
UniRef50_UPI0000DB6CB9 Cluster: PREDICTED: similar to PaTched Re... 103 4e-21
UniRef50_Q01KH5 Cluster: H0409D10.4 protein; n=5; Eukaryota|Rep:... 74 5e-12
UniRef50_A7QPC0 Cluster: Chromosome chr18 scaffold_137, whole ge... 71 5e-11
UniRef50_Q55BN1 Cluster: NPC1 protein; n=2; Dictyostelium discoi... 70 6e-11
UniRef50_A2XWG3 Cluster: Putative uncharacterized protein; n=2; ... 62 1e-08
UniRef50_A5E1Z8 Cluster: Putative uncharacterized protein; n=1; ... 62 1e-08
UniRef50_Q4RWY5 Cluster: Chromosome 15 SCAF14981, whole genome s... 61 3e-08
UniRef50_Q9SHN9 Cluster: F7F22.1; n=2; Arabidopsis thaliana|Rep:... 59 1e-07
UniRef50_A3GGU6 Cluster: Predicted protein; n=5; Saccharomycetal... 59 1e-07
UniRef50_UPI0000DB6C66 Cluster: PREDICTED: hypothetical protein;... 55 3e-06
UniRef50_UPI0000586B35 Cluster: PREDICTED: similar to Niemann-Pi... 54 3e-06
UniRef50_A7RNK5 Cluster: Predicted protein; n=1; Nematostella ve... 53 1e-05
UniRef50_Q00U42 Cluster: Novel protein; n=2; Ostreococcus|Rep: N... 52 1e-05
UniRef50_O15118 Cluster: Niemann-Pick C1 protein precursor; n=39... 52 2e-05
UniRef50_Q17GY7 Cluster: Patched 1, putative; n=11; Endopterygot... 50 6e-05
UniRef50_Q6CBA1 Cluster: Similar to tr|Q12200 Saccharomyces cere... 50 6e-05
UniRef50_Q4PE83 Cluster: Putative uncharacterized protein; n=1; ... 50 7e-05
UniRef50_UPI000069E05B Cluster: Niemann-Pick C1-like protein 1 p... 48 4e-04
UniRef50_A5APM6 Cluster: Putative uncharacterized protein; n=1; ... 47 5e-04
UniRef50_A7S0G1 Cluster: Predicted protein; n=1; Nematostella ve... 47 5e-04
UniRef50_Q5KGS9 Cluster: Vacuolar membrane protein, putative; n=... 47 7e-04
UniRef50_P18502 Cluster: Protein patched; n=3; Diptera|Rep: Prot... 46 0.001
UniRef50_Q9SVF0 Cluster: Putative uncharacterized protein F22I13... 45 0.003
UniRef50_A7RK33 Cluster: Predicted protein; n=2; Nematostella ve... 45 0.003
UniRef50_P34389 Cluster: Niemann-Pick C1 protein homolog 2 precu... 44 0.004
UniRef50_Q9UHC9 Cluster: Niemann-Pick C1-like protein 1 precurso... 44 0.006
UniRef50_Q12200 Cluster: Niemann-pick type C-related protein 1 p... 43 0.008
UniRef50_A0CEP2 Cluster: Chromosome undetermined scaffold_172, w... 43 0.011
UniRef50_A2QWF9 Cluster: Remark: Niemann-Pick C precursor; n=16;... 42 0.026
UniRef50_Q09614 Cluster: Protein patched homolog 1; n=3; Caenorh... 41 0.034
UniRef50_Q9U1R3 Cluster: Putative uncharacterized protein ptr-22... 41 0.045
UniRef50_A6LPA5 Cluster: Putative uncharacterized protein; n=1; ... 40 0.10
UniRef50_UPI00015B5F3E Cluster: PREDICTED: similar to CG5722-PA;... 39 0.14
UniRef50_UPI000065FF0C Cluster: Niemann-Pick C1-like protein 1 p... 39 0.14
UniRef50_Q23E28 Cluster: Patched family protein; n=1; Tetrahymen... 39 0.18
UniRef50_Q0AT82 Cluster: Patched family protein precursor; n=2; ... 38 0.32
UniRef50_Q9Y6C5 Cluster: Protein patched homolog 2; n=14; Theria... 38 0.32
UniRef50_Q95YD0 Cluster: Patched related family protein 4; n=2; ... 38 0.42
UniRef50_Q13635 Cluster: Protein patched homolog 1; n=79; Verteb... 38 0.42
UniRef50_Q53ML3 Cluster: Putative uncharacterized protein; n=1; ... 37 0.73
UniRef50_UPI0000DA2841 Cluster: PREDICTED: similar to patched1; ... 36 1.3
UniRef50_Q4T749 Cluster: Chromosome undetermined SCAF8317, whole... 36 1.3
UniRef50_A7DNH6 Cluster: Vitamin K-dependent gamma-carboxylase; ... 36 1.7
UniRef50_Q19127 Cluster: Niemann-Pick C1 protein homolog 1 precu... 36 1.7
UniRef50_Q8NRN1 Cluster: Acyl-CoA dehydrogenases; n=1; Corynebac... 35 2.2
UniRef50_Q8D273 Cluster: YtfN protein; n=1; Wigglesworthia gloss... 35 2.9
UniRef50_A7SH24 Cluster: Predicted protein; n=5; Nematostella ve... 35 2.9
UniRef50_Q5TJ79 Cluster: Putative uncharacterized protein; n=2; ... 34 3.9
UniRef50_Q2FPB2 Cluster: Hydrophobe/amphiphile efflux-3 HAE3 pre... 34 3.9
UniRef50_UPI00015B5B2F Cluster: PREDICTED: similar to putative h... 34 5.1
UniRef50_UPI0000E48C80 Cluster: PREDICTED: similar to Fbxw9 prot... 34 5.1
UniRef50_Q4RVD6 Cluster: Chromosome 15 SCAF14992, whole genome s... 34 5.1
UniRef50_UPI0000D55472 Cluster: PREDICTED: similar to Patched pr... 33 6.8
UniRef50_O44978 Cluster: Patched related family protein 11; n=2;... 33 6.8
UniRef50_A7F1R8 Cluster: Putative uncharacterized protein; n=1; ... 33 6.8
UniRef50_Q6MP63 Cluster: Acriflavin resistance protein; n=2; Bde... 33 9.0
UniRef50_Q54N25 Cluster: Putative uncharacterized protein; n=1; ... 33 9.0
>UniRef50_UPI00015B5B0C Cluster: PREDICTED: similar to conserved
hypothetical protein; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to conserved hypothetical protein -
Nasonia vitripennis
Length = 957
Score = 120 bits (289), Expect = 5e-26
Identities = 56/148 (37%), Positives = 90/148 (60%), Gaps = 1/148 (0%)
Frame = +3
Query: 342 KMSKKKNVKTPQQIWEGVSSVSVHFVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLI 521
++ KK ++PQ+ + V VE F++LG+ +AK P + + + V + GL+
Sbjct: 2 EIEKKPYRRSPQEALYRIPQVISKLVERFFYNLGLQIAKKPKRWMICCSVLVILCLAGLL 61
Query: 522 RFHIEKNPMNLWVPPDSDFYHDTNWYIKTFGTGLRLQNIIFTANDVLHPDVLIEINDITE 701
RF EKNP+ LWVPPDSDF DT W TF G R++ +IF A+D+L P L+++N+IT
Sbjct: 62 RFRQEKNPLKLWVPPDSDFVRDTEWLTSTFKEGQRIERMIFAADDILEPQALLKLNEITL 121
Query: 702 KISALNVKYEN-QSISLTDLCYKVPVVN 782
++ N + + S TD+C+KVP+++
Sbjct: 122 RV--FNAQTQTIPKTSWTDICFKVPIIS 147
>UniRef50_UPI0000DB6CB9 Cluster: PREDICTED: similar to PaTched
Related family member (ptr-19); n=1; Apis mellifera|Rep:
PREDICTED: similar to PaTched Related family member
(ptr-19) - Apis mellifera
Length = 881
Score = 103 bits (248), Expect = 4e-21
Identities = 49/122 (40%), Positives = 78/122 (63%)
Frame = +3
Query: 417 VESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTNW 596
VE F+ LG+ +A+ P + I G+ + V +S GL FH EKNP+ LWVP DS+F DT W
Sbjct: 28 VEHFFYELGLRIARSPLKWIIGSAVIVLISLSGLYFFHQEKNPIRLWVPQDSEFVRDTEW 87
Query: 597 YIKTFGTGLRLQNIIFTANDVLHPDVLIEINDITEKISALNVKYENQSISLTDLCYKVPV 776
+ F LRL+N+I TA+++L P++L + ++++ +Q I+ TD+C+KVPV
Sbjct: 88 MFEKFDQSLRLENMILTADNILEPEILAK--------QIISIQTPDQ-IAWTDICFKVPV 138
Query: 777 VN 782
++
Sbjct: 139 IS 140
>UniRef50_Q01KH5 Cluster: H0409D10.4 protein; n=5; Eukaryota|Rep:
H0409D10.4 protein - Oryza sativa (Rice)
Length = 1372
Score = 73.7 bits (173), Expect = 5e-12
Identities = 50/198 (25%), Positives = 89/198 (44%), Gaps = 9/198 (4%)
Frame = +3
Query: 201 ITLFRYVMCCYSLVVYLCLHYKNYLRNHTK*IWR-EIKSYSTSAVNCSKMSKKKNVKTPQ 377
+ ++ ++C + +L ++ + +HTK + E K +S++ S + +
Sbjct: 295 VVVYLVLLCIFLFGAFLHRTRRSGIFSHTKPLKNAEDKIHSSNNGKVPDSSAQVSEAASA 354
Query: 378 QIWEGVSSVSVHFVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLW 557
+ SV ++ + F G FVAKHP V+F +LL T+ CIGLIRF +E P LW
Sbjct: 355 PVQSAHPSVIQTYMSTFFRKHGTFVAKHPLLVLFVSLLVPTLLCIGLIRFKVEIRPEKLW 414
Query: 558 VPPDSDFYHDTNWYIKTFGTGLRLQNIIFTANDVLHPDVLIEIND--------ITEKISA 713
V S + ++ R++ ++ + + +ND I +KI
Sbjct: 415 VSSGSRAADEKQYFDSHLAPFYRIEQLVLATSAFGGSEAPTIVNDNNMKLLFQIQKKIDD 474
Query: 714 LNVKYENQSISLTDLCYK 767
L Y ++SL D+C K
Sbjct: 475 LRANYSGSTVSLADICLK 492
>UniRef50_A7QPC0 Cluster: Chromosome chr18 scaffold_137, whole
genome shotgun sequence; n=1; Vitis vinifera|Rep:
Chromosome chr18 scaffold_137, whole genome shotgun
sequence - Vitis vinifera (Grape)
Length = 1263
Score = 70.5 bits (165), Expect = 5e-11
Identities = 42/139 (30%), Positives = 69/139 (49%), Gaps = 9/139 (6%)
Frame = +3
Query: 378 QIWEGVS-SVSVHFVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNL 554
QI GV S+ ++ + + G +VA+HP ++ +L V V C+GLIRF +E P L
Sbjct: 302 QIRNGVQLSIVQGYMSNFYRRYGTWVARHPTIMLCSSLAIVLVLCLGLIRFKVETRPEKL 361
Query: 555 WVPPDSDFYHDTNWYIKTFGTGLRLQNIIF-TANDV--LHPDVLIEIN-----DITEKIS 710
WV P S + ++ R++ ++ T D + P ++ E N +I +K+
Sbjct: 362 WVGPGSKAAEEKQFFDSHLAPFYRIEQLVLATIPDANGISPSIVTENNIKLLFEIQKKVD 421
Query: 711 ALNVKYENQSISLTDLCYK 767
L + ISLTD+C K
Sbjct: 422 GLRANFSGSMISLTDICMK 440
>UniRef50_Q55BN1 Cluster: NPC1 protein; n=2; Dictyostelium
discoideum|Rep: NPC1 protein - Dictyostelium discoideum
AX4
Length = 1342
Score = 70.1 bits (164), Expect = 6e-11
Identities = 39/123 (31%), Positives = 65/123 (52%), Gaps = 6/123 (4%)
Frame = +3
Query: 417 VESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTNW 596
++ F+ G VA P VI ++ IG+I+ IE++P+ LWV PDS D +
Sbjct: 408 IQRFFYWYGHKVASKPLIVILICIIITAGLGIGIIKLEIEQDPVKLWVAPDSRAALDKTY 467
Query: 597 YIKTFGTGLRLQNIIFTAND------VLHPDVLIEINDITEKISALNVKYENQSISLTDL 758
+ FG R++ II T + V+ D+L+E+ +I + +L +YE + I+L L
Sbjct: 468 FDNNFGPFYRVEQIIITPKNQTKYPTVIEYDLLLELFEIELSLMSLEAEYEGELITLDSL 527
Query: 759 CYK 767
C+K
Sbjct: 528 CFK 530
>UniRef50_A2XWG3 Cluster: Putative uncharacterized protein; n=2;
Oryza sativa|Rep: Putative uncharacterized protein -
Oryza sativa subsp. indica (Rice)
Length = 1158
Score = 62.5 bits (145), Expect = 1e-08
Identities = 41/170 (24%), Positives = 77/170 (45%), Gaps = 1/170 (0%)
Frame = +3
Query: 201 ITLFRYVMCCYSLVVYLCLHYKNYLRNHTK*IWR-EIKSYSTSAVNCSKMSKKKNVKTPQ 377
+ ++ ++C + +L ++ + +HTK + E K +S++ S + +
Sbjct: 180 VVVYLVLLCIFLFGAFLHRTRRSGIFSHTKPLKNAEDKIHSSNNGKVPDSSAQVSEAASA 239
Query: 378 QIWEGVSSVSVHFVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLW 557
+ SV ++ + F G FVAKHP V+F +LL T+ CIGLIRF +E P LW
Sbjct: 240 PVQSAHPSVIQTYMSTFFRKHGTFVAKHPLLVLFVSLLVPTLLCIGLIRFKVEIRPEKLW 299
Query: 558 VPPDSDFYHDTNWYIKTFGTGLRLQNIIFTANDVLHPDVLIEINDITEKI 707
V S + ++ R++ ++ + + +ND K+
Sbjct: 300 VSSGSRAADEKQYFDSHLAPFYRIEQLVLATSAFGGSEAPTIVNDNNMKL 349
>UniRef50_A5E1Z8 Cluster: Putative uncharacterized protein; n=1;
Lodderomyces elongisporus NRRL YB-4239|Rep: Putative
uncharacterized protein - Lodderomyces elongisporus
(Yeast) (Saccharomyces elongisporus)
Length = 1191
Score = 62.5 bits (145), Expect = 1e-08
Identities = 32/119 (26%), Positives = 62/119 (52%), Gaps = 1/119 (0%)
Frame = +3
Query: 414 FVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTN 593
++++ F LG F + P VI +L+ +G+ +E NP+NLWV P+ Y +
Sbjct: 184 YIQNSFAKLGRFCSTFPGIVIGFSLIISLALSLGIFNLQLETNPINLWVSPNEPAYINQQ 243
Query: 594 WYIKTFGTGLRLQNIIFTANDVLHPDVLIEINDITEKI-SALNVKYENQSISLTDLCYK 767
++ K FG R++ +I ++ + P + I+ L ++ N+ +SL+D+C+K
Sbjct: 244 YFEKNFGEWFRVEQVIISSKNATEP--IFNWQTISWWFEQELKLENLNKVVSLSDICFK 300
>UniRef50_Q4RWY5 Cluster: Chromosome 15 SCAF14981, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 15 SCAF14981, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 1209
Score = 61.3 bits (142), Expect = 3e-08
Identities = 41/135 (30%), Positives = 62/135 (45%), Gaps = 19/135 (14%)
Frame = +3
Query: 414 FVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTN 593
++ S F G F HP V+ G+L+ V S GLI I +P++LW P S +
Sbjct: 277 YLRSCFSCWGSFCVLHPCVVLLGSLILVVASSGGLIYMRITTDPVDLWSSPSSQARQERE 336
Query: 594 WYIKTFGTGLRLQNIIFTA--ND-----------------VLHPDVLIEINDITEKISAL 716
++ FG R +I T+ ND VL D+L ++ D+ I +L
Sbjct: 337 YFDSHFGPFFRTAQLIITSPLNDTFLYSPVMGGPDIPFKAVLSKDILHQVLDLQLDIESL 396
Query: 717 NVKYENQSISLTDLC 761
YE QS++L D+C
Sbjct: 397 VATYEGQSVTLKDIC 411
>UniRef50_Q9SHN9 Cluster: F7F22.1; n=2; Arabidopsis thaliana|Rep:
F7F22.1 - Arabidopsis thaliana (Mouse-ear cress)
Length = 1275
Score = 59.3 bits (137), Expect = 1e-07
Identities = 38/125 (30%), Positives = 64/125 (51%), Gaps = 9/125 (7%)
Frame = +3
Query: 369 TPQQIWEGVSSVSVHFVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPM 548
TPQ+ W +S+V H + + GI+VA+HP V+ ++ V + C+GLIRF +E P
Sbjct: 318 TPQRNWGQLSTVQGHLA-NFYGKYGIWVARHPTLVLCLSVSVVLLLCVGLIRFKVETRPD 376
Query: 549 NLWVPPDSDFYHDTNWYIKTFGTGLRLQNIIF----TANDVLHPDVLIEIN-----DITE 701
LWV S + ++ R++ +I T++ P++L + N DI +
Sbjct: 377 KLWVGSGSRAAEEKQFFDTHLAPFYRIEQLIIATVQTSSHEKAPEILTDDNIKLLFDIQK 436
Query: 702 KISAL 716
K+S L
Sbjct: 437 KVSQL 441
>UniRef50_A3GGU6 Cluster: Predicted protein; n=5;
Saccharomycetales|Rep: Predicted protein - Pichia
stipitis (Yeast)
Length = 1268
Score = 59.3 bits (137), Expect = 1e-07
Identities = 35/136 (25%), Positives = 63/136 (46%), Gaps = 1/136 (0%)
Frame = +3
Query: 363 VKTPQQIWEGVSSVSVHFVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKN 542
VK P + + +E+ F S+G F + +P VI L+ + GL E +
Sbjct: 312 VKKPMSSFSNWHLRLIEKIENTFASVGYFCSSYPGLVISFNLVLTLILSSGLFWLQFETD 371
Query: 543 PMNLWVPPDSDFYHDTNWYIKTFGTGLRLQNIIFTANDVLHPDVLIEINDITEKISALNV 722
P+ LWV P + ++ +FG R++ II + + P ++ N+I
Sbjct: 372 PVKLWVSPQEPALKNMQYFESSFGEWFRIEQIIVSNKNDSEP--ILNWNNIRWWFEKERQ 429
Query: 723 KYE-NQSISLTDLCYK 767
Y N+++SL+D+C+K
Sbjct: 430 LYSLNENVSLSDICFK 445
>UniRef50_UPI0000DB6C66 Cluster: PREDICTED: hypothetical protein;
n=1; Apis mellifera|Rep: PREDICTED: hypothetical protein
- Apis mellifera
Length = 175
Score = 54.8 bits (126), Expect = 3e-06
Identities = 31/122 (25%), Positives = 57/122 (46%), Gaps = 3/122 (2%)
Frame = +3
Query: 333 NCSKMSKKKNVKTPQQIWEGVSSV--SVHF-VESIFFSLGIFVAKHPWQVIFGTLLFVTV 503
N S + + +W+ + + +H + +F+ +G+ + K PW + +
Sbjct: 51 NLSARMESHRGRNANNVWKRLKDLLLDLHLNSDRLFYRIGLSIGKRPWLWLLVCFCINCI 110
Query: 504 SCIGLIRFHIEKNPMNLWVPPDSDFYHDTNWYIKTFGTGLRLQNIIFTANDVLHPDVLIE 683
GLI + E + + L+VP DS +D W F R ++II TA +VL P+VL
Sbjct: 111 CAPGLIFWREELDDIELFVPEDSIIRNDAAWVKTHFRDDFRYESIIVTAPNVLEPEVLRS 170
Query: 684 IN 689
++
Sbjct: 171 VH 172
>UniRef50_UPI0000586B35 Cluster: PREDICTED: similar to Niemann-Pick
C disease protein isoform 1; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to Niemann-Pick C
disease protein isoform 1 - Strongylocentrotus
purpuratus
Length = 1332
Score = 54.4 bits (125), Expect = 3e-06
Identities = 42/171 (24%), Positives = 78/171 (45%), Gaps = 22/171 (12%)
Frame = +3
Query: 318 STSAVNCSKMSKKKNVKTPQQIWEGVSSVSVH-FVESIFFSLGIFVAKHPWQVIFGTLLF 494
+++AVN + +K + + + ++ +E F LG VA HP V+ ++
Sbjct: 337 TSTAVNSVNGANRKEISEDEVGCKASCGMAFQKLLELCFRKLGTLVAGHPHIVLVLGVMV 396
Query: 495 VTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTNWYIKTFGTGLRLQNIIFTAND------ 656
VT G++R + +P+ LW PP S+ + ++ + FG R + II TA +
Sbjct: 397 VTAMTAGMVRLKVTTDPVELWSPPTSESRLEKAYFDEHFGPFFRTEQIILTAPERKPYNV 456
Query: 657 --------------VLHPDVLIEINDITEKISALNVKYENQS-ISLTDLCY 764
+L D+L + D+ + + L V + N S ++L D+CY
Sbjct: 457 TRQYPSEATTTYGGILSIDLLHQALDLQDAVVNLKVPFGNDSFVTLHDICY 507
>UniRef50_A7RNK5 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 1507
Score = 52.8 bits (121), Expect = 1e-05
Identities = 33/125 (26%), Positives = 57/125 (45%)
Frame = +3
Query: 396 SSVSVHFVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSD 575
S S+ + LG + ++PW I + + IGL+ F E LW DS
Sbjct: 601 SDHSIGLYRLLRIKLGAKIGRNPWITIIICFVVSGLWIIGLLNFTEENRGEKLWAADDSI 660
Query: 576 FYHDTNWYIKTFGTGLRLQNIIFTANDVLHPDVLIEINDITEKISALNVKYENQSISLTD 755
+W F + R+ +I+ A++VL P VL ++ +I +K+ + EN S
Sbjct: 661 AIKHGDWVSANFPSQSRISSILVVASNVLVPAVLTQLLEIDKKVKLIKNGTEN---SWEK 717
Query: 756 LCYKV 770
LC+++
Sbjct: 718 LCFRL 722
>UniRef50_Q00U42 Cluster: Novel protein; n=2; Ostreococcus|Rep:
Novel protein - Ostreococcus tauri
Length = 853
Score = 52.4 bits (120), Expect = 1e-05
Identities = 35/144 (24%), Positives = 61/144 (42%), Gaps = 5/144 (3%)
Frame = +3
Query: 351 KKKNVKTPQQIWEGVSSVSVHFVESIFFSLGIFVAKHPWQVIFGTLLFVTVSC--IGLIR 524
K +V+ P + +++ F F++LG A PW +I T++ + +G
Sbjct: 38 KTTSVELPSTCGDKLANGVNGFFGKKFYALGRASASRPWTMIACTVVLCVIFSGGVGYPG 97
Query: 525 FHIEKNPMNLWVPPDSDFYHDTNWYIKTFGTGLRLQNIIFTAND---VLHPDVLIEINDI 695
E LWVP D+ D + +G R I T D VL P+ L + +
Sbjct: 98 LKNENRGDRLWVPTDTPAQDDKTFVDTYYGAETRFAQAILTKTDGSNVLTPEGLTALRTV 157
Query: 696 TEKISALNVKYENQSISLTDLCYK 767
+SA+++ +E + D CY+
Sbjct: 158 ATGVSAVSITWEGATYGYNDHCYR 181
>UniRef50_O15118 Cluster: Niemann-Pick C1 protein precursor; n=39;
Chordata|Rep: Niemann-Pick C1 protein precursor - Homo
sapiens (Human)
Length = 1278
Score = 51.6 bits (118), Expect = 2e-05
Identities = 36/142 (25%), Positives = 65/142 (45%), Gaps = 19/142 (13%)
Frame = +3
Query: 393 VSSVSVHFVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDS 572
VS+ + +F G F ++P VIF +L+F+T GL+ + NP++LW P S
Sbjct: 327 VSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSS 386
Query: 573 DFYHDTNWYIKTFGTGLRLQNIIFTA--------------NDV-----LHPDVLIEINDI 695
+ ++ + FG R + +I A DV L +L ++ D+
Sbjct: 387 QARLEKEYFDQHFGPFFRTEQLIIRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDL 446
Query: 696 TEKISALNVKYENQSISLTDLC 761
I + Y+N++++L D+C
Sbjct: 447 QIAIENITASYDNETVTLQDIC 468
>UniRef50_Q17GY7 Cluster: Patched 1, putative; n=11;
Endopterygota|Rep: Patched 1, putative - Aedes aegypti
(Yellowfever mosquito)
Length = 1116
Score = 50.4 bits (115), Expect = 6e-05
Identities = 31/128 (24%), Positives = 59/128 (46%), Gaps = 6/128 (4%)
Frame = +3
Query: 420 ESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTNWY 599
+S ++LG + KH +V+F +L ++ C+GL + LW+ H+ +
Sbjct: 17 QSHLYNLGCSIQKHAGKVLFVAILVLSTFCVGLKSATVHSKVHQLWIQEGGTLEHELAYT 76
Query: 600 IKTFG--TGLRLQNIIFTAND----VLHPDVLIEINDITEKISALNVKYENQSISLTDLC 761
K+ G Q +I T D +LH + L+ ++ ++ ++ V + SL D+C
Sbjct: 77 QKSLGEMDSSTHQLLIQTPKDMEASILHANALLTHLEVVKQAISVRVHMYDIEWSLKDMC 136
Query: 762 YKVPVVNF 785
Y + NF
Sbjct: 137 YSPNIPNF 144
>UniRef50_Q6CBA1 Cluster: Similar to tr|Q12200 Saccharomyces
cerevisiae YPL006W NCR1; n=1; Yarrowia lipolytica|Rep:
Similar to tr|Q12200 Saccharomyces cerevisiae YPL006W
NCR1 - Yarrowia lipolytica (Candida lipolytica)
Length = 1239
Score = 50.4 bits (115), Expect = 6e-05
Identities = 31/112 (27%), Positives = 52/112 (46%), Gaps = 2/112 (1%)
Frame = +3
Query: 438 LGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTNWYIKTFGT 617
+ +F A +P I T+ + +GL RF +E+NP+ LWV DS Y + FG
Sbjct: 337 IALFCASYPAVTIGFTVTLSILMSVGLTRFQVEENPVRLWVSEDSTPYLQKENFDNNFGP 396
Query: 618 GLRLQNI--IFTANDVLHPDVLIEINDITEKISALNVKYENQSISLTDLCYK 767
R + + T V++ + L+ + ++I +L V + S D C K
Sbjct: 397 FYRTAQVYLVNTTGSVVNQENLVWWQGVEQQIISLQV----EGTSFNDFCLK 444
>UniRef50_Q4PE83 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 1489
Score = 50.0 bits (114), Expect = 7e-05
Identities = 24/70 (34%), Positives = 36/70 (51%)
Frame = +3
Query: 429 FFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTNWYIKT 608
F+ LG+ A+HPW +FV ++ IG F +E +P+ LWV P S + + +
Sbjct: 406 FYRLGLLCARHPWLTFILAAVFVGIANIGWKDFEVEVDPVRLWVAPGSTAKMQKDIFDQE 465
Query: 609 FGTGLRLQNI 638
FG R Q I
Sbjct: 466 FGPFYRPQQI 475
>UniRef50_UPI000069E05B Cluster: Niemann-Pick C1-like protein 1
precursor.; n=2; Xenopus tropicalis|Rep: Niemann-Pick
C1-like protein 1 precursor. - Xenopus tropicalis
Length = 1260
Score = 47.6 bits (108), Expect = 4e-04
Identities = 33/128 (25%), Positives = 60/128 (46%), Gaps = 20/128 (15%)
Frame = +3
Query: 441 GIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTNWYIKTFGTG 620
G VA +P VI +L+ V + G+I + +P+ LW +S + +++ FG
Sbjct: 340 GTLVASYPKTVIGVSLIVVIILSAGIILIRLTTDPVELWSAVNSQARQEKDFHDANFGPF 399
Query: 621 LRLQNIIFTAND------------------VLHPDVLIEINDITEKISALNVKYE--NQS 740
R +I TA + +L PD ++E+ D+ EK+ + V E ++
Sbjct: 400 FRTNQLIITAKNRVSYPYDSLFFGKLNFSGILSPDTIMEMLDLQEKVQNIVVWSEKHQKN 459
Query: 741 ISLTDLCY 764
++L D+CY
Sbjct: 460 VTLKDICY 467
>UniRef50_A5APM6 Cluster: Putative uncharacterized protein; n=1;
Vitis vinifera|Rep: Putative uncharacterized protein -
Vitis vinifera (Grape)
Length = 1050
Score = 47.2 bits (107), Expect = 5e-04
Identities = 38/131 (29%), Positives = 59/131 (45%), Gaps = 1/131 (0%)
Frame = +3
Query: 378 QIWEGVS-SVSVHFVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNL 554
QI GV S+ ++ + + G +VA+HP ++ +L V V C+GLIRF +E P L
Sbjct: 302 QIRNGVQLSIVQGYMSNFYRRYGTWVARHPTIMLCSSLAIVLVLCLGLIRFKVETRPEKL 361
Query: 555 WVPPDSDFYHDTNWYIKTFGTGLRLQNIIFTANDVLHPDVLIEINDITEKISALNVKYEN 734
+ T + I T N++ +L EI +K+ L +
Sbjct: 362 --------------VLATIPDANGISPSIVTENNI---KLLFEIQ---KKVDGLRANFSG 401
Query: 735 QSISLTDLCYK 767
ISLTD+C K
Sbjct: 402 SMISLTDICMK 412
>UniRef50_A7S0G1 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 1277
Score = 47.2 bits (107), Expect = 5e-04
Identities = 23/79 (29%), Positives = 40/79 (50%)
Frame = +3
Query: 417 VESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTNW 596
+ IF G++ + HP+ VI G ++FV + G+ + I K+P+ LW P S + +
Sbjct: 318 LRKIFSLWGLWCSNHPYTVIAGCIVFVGILAGGVGYYSIIKDPVKLWSAPQSRARQEKDL 377
Query: 597 YIKTFGTGLRLQNIIFTAN 653
+ F R + +I T N
Sbjct: 378 FDSKFSPFYRTEQLIITVN 396
>UniRef50_Q5KGS9 Cluster: Vacuolar membrane protein, putative; n=2;
Filobasidiella neoformans|Rep: Vacuolar membrane
protein, putative - Cryptococcus neoformans
(Filobasidiella neoformans)
Length = 1330
Score = 46.8 bits (106), Expect = 7e-04
Identities = 31/114 (27%), Positives = 54/114 (47%), Gaps = 2/114 (1%)
Frame = +3
Query: 429 FFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTNWYIKT 608
F+ LG+ AK P +V + L V + G F +E +P+ LWV P S+ ++ +
Sbjct: 349 FYRLGLTCAKRPIEVFAISALIVGLFNFGWKYFEVETDPVRLWVSPTSESASQKQFFDDS 408
Query: 609 FGTGLRLQNIIFT--ANDVLHPDVLIEINDITEKISALNVKYENQSISLTDLCY 764
FG + + I T + ++ D L + +I+AL + I L D+C+
Sbjct: 409 FGPFYKSEQIFITQSSGSPVNYDTLDWWLKVETEINALKT---SDGIGLEDICF 459
>UniRef50_P18502 Cluster: Protein patched; n=3; Diptera|Rep: Protein
patched - Drosophila melanogaster (Fruit fly)
Length = 1286
Score = 46.0 bits (104), Expect = 0.001
Identities = 32/115 (27%), Positives = 51/115 (44%), Gaps = 6/115 (5%)
Frame = +3
Query: 435 SLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTNWYIKTFG 614
+LG V KH +V+F +L ++ C+GL I LW+ + + KT G
Sbjct: 65 TLGSSVQKHAGKVLFVAILVLSTFCVGLKSAQIHSKVHQLWIQEGGRLEAELAYTQKTIG 124
Query: 615 --TGLRLQNIIFTAND----VLHPDVLIEINDITEKISALNVKYENQSISLTDLC 761
Q +I T +D VLHP L+ ++ K +A+ V + L D+C
Sbjct: 125 EDESATHQLLIQTTHDPNASVLHPQALLAHLEVLVKATAVKVHLYDTEWGLRDMC 179
>UniRef50_Q9SVF0 Cluster: Putative uncharacterized protein
F22I13.120; n=2; Arabidopsis thaliana|Rep: Putative
uncharacterized protein F22I13.120 - Arabidopsis
thaliana (Mouse-ear cress)
Length = 1055
Score = 44.8 bits (101), Expect = 0.003
Identities = 20/76 (26%), Positives = 38/76 (50%)
Frame = +3
Query: 414 FVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTN 593
++ + S G ++A++P V+F ++ V C GL F +E P LWV P+S +
Sbjct: 291 YMAKFYRSYGSWIARNPSLVLFMSVAIVLALCSGLYNFKVETRPEKLWVGPESKAAEEKK 350
Query: 594 WYIKTFGTGLRLQNII 641
++ R++ +I
Sbjct: 351 FFDTHLSPFYRIEQLI 366
>UniRef50_A7RK33 Cluster: Predicted protein; n=2; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 1120
Score = 44.8 bits (101), Expect = 0.003
Identities = 32/122 (26%), Positives = 55/122 (45%), Gaps = 6/122 (4%)
Frame = +3
Query: 417 VESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTNW 596
V+ + F++G KH +V+ ++ + V IGL R +E N LWV + +
Sbjct: 24 VQLLLFTIGCNAQKHCGKVVLLGIVAMCVCGIGLDRIQMETNAEKLWVEAGGRLEEELAY 83
Query: 597 YIKTFGTGLRLQN--IIFTAN----DVLHPDVLIEINDITEKISALNVKYENQSISLTDL 758
G G II T N ++L P+ L+ + K + + V +N+ +L +L
Sbjct: 84 TKGALGEGFGASQELIIQTPNIEGTNILTPNALLLHLEAVRKATKVTVTIDNKKWTLKEL 143
Query: 759 CY 764
CY
Sbjct: 144 CY 145
>UniRef50_P34389 Cluster: Niemann-Pick C1 protein homolog 2
precursor; n=2; Caenorhabditis|Rep: Niemann-Pick C1
protein homolog 2 precursor - Caenorhabditis elegans
Length = 1274
Score = 44.4 bits (100), Expect = 0.004
Identities = 31/130 (23%), Positives = 53/130 (40%), Gaps = 4/130 (3%)
Frame = +3
Query: 390 GVSSVSVHFVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPD 569
G ++ V F E + V KHP + L+ C G +FH + ++ D
Sbjct: 309 GKGNLEVQF-EGLCARYANAVIKHPLIFVSLGLIVAAACCSGNFKFHSLTHSVDQVSAAD 367
Query: 570 SDFYHDTNWYIKTFGTGLRLQNIIF----TANDVLHPDVLIEINDITEKISALNVKYENQ 737
+ + +I +FG R++ I T + + + E+ + I L Y N
Sbjct: 368 GETRRNEKKFIHSFGPNHRIEQIFINLPPTTKSMFNMPLFEEMFQLVGNIQNLTACYGNS 427
Query: 738 SISLTDLCYK 767
S+ L D+CYK
Sbjct: 428 SVKLDDICYK 437
>UniRef50_Q9UHC9 Cluster: Niemann-Pick C1-like protein 1 precursor;
n=23; Tetrapoda|Rep: Niemann-Pick C1-like protein 1
precursor - Homo sapiens (Human)
Length = 1359
Score = 43.6 bits (98), Expect = 0.006
Identities = 36/143 (25%), Positives = 65/143 (45%), Gaps = 21/143 (14%)
Frame = +3
Query: 399 SVSVHFVESIFFS-LGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSD 575
S S H + FF G +VA P ++ +++ V GL+ + +P+ LW P+S
Sbjct: 330 SFSTHTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQ 389
Query: 576 FYHDTNWYIKTFGTGLRLQNIIFTA------------------NDVLHPDVLIEINDITE 701
+ ++ + FG R +I TA + +L D+L+E+ ++ E
Sbjct: 390 ARSEKAFHDQHFGPFFRTNQVILTAPNRSSYRYDSLLLGPKNFSGILDLDLLLELLELQE 449
Query: 702 KISALNV--KYENQSISLTDLCY 764
++ L V ++ISL D+CY
Sbjct: 450 RLRHLQVWSPEAQRNISLQDICY 472
>UniRef50_Q12200 Cluster: Niemann-pick type C-related protein 1
precursor; n=7; Saccharomycetales|Rep: Niemann-pick type
C-related protein 1 precursor - Saccharomyces cerevisiae
(Baker's yeast)
Length = 1170
Score = 43.2 bits (97), Expect = 0.008
Identities = 30/119 (25%), Positives = 60/119 (50%), Gaps = 4/119 (3%)
Frame = +3
Query: 423 SIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFH-IEKNPMNLWVPPDSDFYHDTNWY 599
++F +G F ++P++++ T+ + V + ++ +E +P+NLWV +S+ + + ++
Sbjct: 325 NLFTKVGQFSVENPYKILITTVFSIFVFSFIIFQYATLETDPINLWVSKNSEKFKEKEYF 384
Query: 600 IKTFGTGLRLQNIIFTAND---VLHPDVLIEINDITEKISALNVKYENQSISLTDLCYK 767
FG R + IF N+ VL + L D+ I+ EN I DLC++
Sbjct: 385 DDNFGPFYRTEQ-IFVVNETGPVLSYETLHWWFDVENFITEELQSSEN--IGYQDLCFR 440
>UniRef50_A0CEP2 Cluster: Chromosome undetermined scaffold_172,
whole genome shotgun sequence; n=3; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_172,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 912
Score = 42.7 bits (96), Expect = 0.011
Identities = 29/122 (23%), Positives = 50/122 (40%), Gaps = 5/122 (4%)
Frame = +3
Query: 417 VESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTNW 596
+ +F+++G F AK+P V + + +GL + +P +LWV S Y +
Sbjct: 1 MSGLFYNIGYFGAKYPCLVFVICMTVTGIMSLGLYNLTVLTDPQSLWVSSSSRTYQEQES 60
Query: 597 YIKTFGTGLRLQNIIFTAN-----DVLHPDVLIEINDITEKISALNVKYENQSISLTDLC 761
+ +G R I +V D L I + I V ++ +L DLC
Sbjct: 61 SAENYGPFYRTNQFILAYQNEDWVNVFQKDGLKVIYFLQNIIRNRKVLIGGKNTTLDDLC 120
Query: 762 YK 767
Y+
Sbjct: 121 YR 122
>UniRef50_A2QWF9 Cluster: Remark: Niemann-Pick C precursor; n=16;
Pezizomycotina|Rep: Remark: Niemann-Pick C precursor -
Aspergillus niger
Length = 1277
Score = 41.5 bits (93), Expect = 0.026
Identities = 23/85 (27%), Positives = 40/85 (47%)
Frame = +3
Query: 417 VESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTNW 596
++ +F +G A+ P I +++ V + +G RF +E +P+ LWV P S + +
Sbjct: 344 LDRMFNRIGGACARFPAITIISSIVVVVLLSLGWFRFAVETDPVRLWVSPTSAAAQEKAY 403
Query: 597 YIKTFGTGLRLQNIIFTANDVLHPD 671
+ FG R + F ND D
Sbjct: 404 FDANFGPFYRAEQ-AFLVNDTSSGD 427
>UniRef50_Q09614 Cluster: Protein patched homolog 1; n=3;
Caenorhabditis|Rep: Protein patched homolog 1 -
Caenorhabditis elegans
Length = 1405
Score = 41.1 bits (92), Expect = 0.034
Identities = 34/139 (24%), Positives = 58/139 (41%), Gaps = 22/139 (15%)
Frame = +3
Query: 417 VESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTNW 596
++ + F+LG V ++ W +I + V C GL HIE + + LWV + N+
Sbjct: 116 IQKLLFALGNTVHRNAWSIILAVSMIFAVCCYGLQYVHIETDIVKLWVAQGGRLDEELNF 175
Query: 597 Y--IKT------------------FGTGLR--LQNIIFTANDVLHPDVLIEINDITEKIS 710
IK G G + +Q + D L L++ +I + I+
Sbjct: 176 LPNIKEAMRNVTGDSGPELPRENGLGGGYQVLIQTPEYEGQDALAAGPLLKHVEIMKHIA 235
Query: 711 ALNVKYENQSISLTDLCYK 767
+ NV SL+D+C+K
Sbjct: 236 SFNVSVHGVDWSLSDICFK 254
>UniRef50_Q9U1R3 Cluster: Putative uncharacterized protein ptr-22;
n=2; Caenorhabditis|Rep: Putative uncharacterized
protein ptr-22 - Caenorhabditis elegans
Length = 859
Score = 40.7 bits (91), Expect = 0.045
Identities = 21/42 (50%), Positives = 28/42 (66%), Gaps = 1/42 (2%)
Frame = +3
Query: 408 VHFVESIFFSLGIFVAKHPWQVIFGTLLFVT-VSCIGLIRFH 530
VH ++ F+ +G FV HP + I G LL VT VSC+G +RFH
Sbjct: 10 VH-MQKFFYKVGYFVGTHPRKCI-GVLLLVTLVSCLGFLRFH 49
>UniRef50_A6LPA5 Cluster: Putative uncharacterized protein; n=1;
Thermosipho melanesiensis BI429|Rep: Putative
uncharacterized protein - Thermosipho melanesiensis
BI429
Length = 323
Score = 39.5 bits (88), Expect = 0.10
Identities = 18/51 (35%), Positives = 30/51 (58%), Gaps = 1/51 (1%)
Frame = +3
Query: 408 VHFVESIFFSLGIFVAKHPWQVIFGTLL-FVTVSCIGLIRFHIEKNPMNLW 557
+ +++S+ S+ + K+PW +IF T L F+TV I F + KN +N W
Sbjct: 196 LEWIDSLQGSIKVLWLKNPWMLIFDTFLYFLTVCMYSYIMFLLVKNTINFW 246
>UniRef50_UPI00015B5F3E Cluster: PREDICTED: similar to CG5722-PA;
n=1; Nasonia vitripennis|Rep: PREDICTED: similar to
CG5722-PA - Nasonia vitripennis
Length = 1253
Score = 39.1 bits (87), Expect = 0.14
Identities = 34/142 (23%), Positives = 54/142 (38%), Gaps = 17/142 (11%)
Frame = +3
Query: 414 FVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDS------- 572
F+ S F +G F AKHP + + G R + NP+ +W P S
Sbjct: 327 FLHSWFLVVGTFFAKHPVSSLAIISNVIVALSFGSSRLIVTSNPIEIWSAPSSRARIEKN 386
Query: 573 -------DFYHDTNWYIKTFGTGL---RLQNIIFTANDVLHPDVLIEINDITEKISALNV 722
FY +IK+ G + N+ + V + ++ + D+ EK+ L
Sbjct: 387 FFDEHFQPFYRTEQIFIKSVGLDKVYNDIDNVTYEFGPVFRKEFMLAVLDLQEKVMQLG- 445
Query: 723 KYENQSISLTDLCYKVPVVNFF 788
+ L +CY PV N F
Sbjct: 446 --QEDGEGLERICY-APVKNDF 464
>UniRef50_UPI000065FF0C Cluster: Niemann-Pick C1-like protein 1
precursor.; n=1; Takifugu rubripes|Rep: Niemann-Pick
C1-like protein 1 precursor. - Takifugu rubripes
Length = 1293
Score = 39.1 bits (87), Expect = 0.14
Identities = 34/143 (23%), Positives = 68/143 (47%), Gaps = 20/143 (13%)
Frame = +3
Query: 396 SSVSVHFVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDS- 572
S ++ F+ S F G +A +P V+ + + V + GL + +P++LW P+S
Sbjct: 327 SQLAQDFLSSKFQIWGTIMATYPLTVLLLSAVTVAILSAGLKSIELTTDPVDLWSAPNSR 386
Query: 573 ----DFYHDTNW--YIKT--------FGTGLRLQNIIFTAND---VLHPDVLIEINDITE 701
+HDTN+ + +T G +++F N+ ++ D++IE+ +
Sbjct: 387 ARQEKAFHDTNFDPFFRTNQLILTAPGREGQVYDSLLFGQNNLSGIISKDLIIELLQLQT 446
Query: 702 KISALNVKYE--NQSISLTDLCY 764
+I + E N++ SL D+C+
Sbjct: 447 RIQNIEFWSEDLNRTASLKDVCF 469
>UniRef50_Q23E28 Cluster: Patched family protein; n=1; Tetrahymena
thermophila SB210|Rep: Patched family protein -
Tetrahymena thermophila SB210
Length = 1207
Score = 38.7 bits (86), Expect = 0.18
Identities = 16/55 (29%), Positives = 27/55 (49%)
Frame = +3
Query: 486 LLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTNWYIKTFGTGLRLQNIIFTA 650
+L V +G++ +E +P NLW P Y + ++ FG R+ II +A
Sbjct: 142 ILITGVFALGMLNLKMETDPQNLWAPNAGRTYSEQKYFNDNFGQFFRINQIIMSA 196
>UniRef50_Q0AT82 Cluster: Patched family protein precursor; n=2;
Proteobacteria|Rep: Patched family protein precursor -
Maricaulis maris (strain MCS10)
Length = 881
Score = 37.9 bits (84), Expect = 0.32
Identities = 19/57 (33%), Positives = 29/57 (50%)
Frame = +3
Query: 405 SVHFVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSD 575
S F++ + LG FV + W+V +L + V+ +GL R I NP+ W D D
Sbjct: 409 STSFLDRMLQPLGRFVVRRSWRVAVIFILAIGVAIVGLSRIEINDNPVK-WFAEDHD 464
>UniRef50_Q9Y6C5 Cluster: Protein patched homolog 2; n=14;
Theria|Rep: Protein patched homolog 2 - Homo sapiens
(Human)
Length = 1203
Score = 37.9 bits (84), Expect = 0.32
Identities = 35/130 (26%), Positives = 56/130 (43%), Gaps = 8/130 (6%)
Frame = +3
Query: 414 FVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTN 593
+ + + FSLG + +H +V+F LL +GL IE N LWV S + +
Sbjct: 39 YFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELH 98
Query: 594 WYIKTFG--TGLRLQNIIFTA----NDVLHPDVLIEINDITEKISALNVKYENQSISLTD 755
+ + G Q +I TA ++L P+ L S + V +S L
Sbjct: 99 YTKEKLGEEAAYTSQMLIQTARQEGENILTPEALGLHLQAALTASKVQVSLYGKSWDLNK 158
Query: 756 LCYK--VPVV 779
+CYK VP++
Sbjct: 159 ICYKSGVPLI 168
>UniRef50_Q95YD0 Cluster: Patched related family protein 4; n=2;
Caenorhabditis|Rep: Patched related family protein 4 -
Caenorhabditis elegans
Length = 960
Score = 37.5 bits (83), Expect = 0.42
Identities = 18/53 (33%), Positives = 28/53 (52%)
Frame = +3
Query: 414 FVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDS 572
+++ +FF GIFVAKH + + L +S GL I + L+VP D+
Sbjct: 13 WMQKVFFKYGIFVAKHQFWFLIVPLALTVLSIPGLFYLQINLDLYRLFVPTDA 65
>UniRef50_Q13635 Cluster: Protein patched homolog 1; n=79;
Vertebrata|Rep: Protein patched homolog 1 - Homo sapiens
(Human)
Length = 1447
Score = 37.5 bits (83), Expect = 0.42
Identities = 37/158 (23%), Positives = 64/158 (40%), Gaps = 6/158 (3%)
Frame = +3
Query: 312 SYSTSAVNCSKMSKKKNVKTPQQIWEGVSSVSVHFVESIFFSLGIFVAKHPWQVIFGTLL 491
SY +A ++SK K +W + F + + F LG ++ K+ + + LL
Sbjct: 54 SYCDAAFALEQISKGKATGRKAPLW-----LRAKF-QRLLFKLGCYIQKNCGKFLVVGLL 107
Query: 492 FVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTNWYIK------TFGTGLRLQNIIFTAN 653
+GL ++E N LWV + N+ + F L +Q
Sbjct: 108 IFGAFAVGLKAANLETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGA 167
Query: 654 DVLHPDVLIEINDITEKISALNVKYENQSISLTDLCYK 767
+VL + L++ D + S ++V N+ L LCYK
Sbjct: 168 NVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYK 205
>UniRef50_Q53ML3 Cluster: Putative uncharacterized protein; n=1;
Oryza sativa (japonica cultivar-group)|Rep: Putative
uncharacterized protein - Oryza sativa subsp. japonica
(Rice)
Length = 142
Score = 36.7 bits (81), Expect = 0.73
Identities = 22/72 (30%), Positives = 36/72 (50%), Gaps = 1/72 (1%)
Frame = +3
Query: 582 HDTNWYIKTFGTGLRLQNIIFTANDVLHPDV-LIEINDITEKISALNVKYENQSISLTDL 758
HD NWY+ T +L N+ +++ V+ +V + NDI I N+KY +Q +
Sbjct: 62 HDRNWYLTTITNTTKL-NLCSSSSKVMSEEVNFSQENDICAYIWG-NLKYSSQKFYAPNF 119
Query: 759 CYKVPVVNFFWL 794
P ++F WL
Sbjct: 120 QAMQPPIHFHWL 131
>UniRef50_UPI0000DA2841 Cluster: PREDICTED: similar to patched1;
n=3; Rattus norvegicus|Rep: PREDICTED: similar to
patched1 - Rattus norvegicus
Length = 941
Score = 35.9 bits (79), Expect = 1.3
Identities = 34/130 (26%), Positives = 57/130 (43%), Gaps = 8/130 (6%)
Frame = +3
Query: 414 FVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTN 593
+ + + FSLG + KH +V+F L+ + +GL IE + LWV S + +
Sbjct: 38 YFQGLLFSLGCRIQKHCGKVLFLGLVALGALALGLRVAVIETDLEQLWVEVGSRVSQELH 97
Query: 594 WYIKTFG--TGLRLQNIIFTAN----DVLHPDVLIEINDITEKISALNVKYENQSISLTD 755
+ + G Q +I TA ++L P+ L S + V +S L
Sbjct: 98 YTKEKLGEEAAYTSQMLIQTARQEGANILTPEALGFHLQAALTASKVQVSLYGKSWDLNK 157
Query: 756 LCYK--VPVV 779
+CYK VP++
Sbjct: 158 ICYKSGVPLI 167
>UniRef50_Q4T749 Cluster: Chromosome undetermined SCAF8317, whole
genome shotgun sequence; n=1; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF8317,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 1132
Score = 35.9 bits (79), Expect = 1.3
Identities = 21/85 (24%), Positives = 38/85 (44%)
Frame = +3
Query: 396 SSVSVHFVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSD 575
S ++ F+ S F G +A +P V+ + + V V G+ + +P+ LW P+S
Sbjct: 263 SQLAQAFLSSKFQIWGTVMATYPLTVLLLSAIIVVVLSAGIKNIELTTDPVELWSAPNSR 322
Query: 576 FYHDTNWYIKTFGTGLRLQNIIFTA 650
+ ++ F R +I TA
Sbjct: 323 ARQEKAFHDTHFDPFFRTNQLILTA 347
>UniRef50_A7DNH6 Cluster: Vitamin K-dependent gamma-carboxylase;
n=1; Candidatus Nitrosopumilus maritimus SCM1|Rep:
Vitamin K-dependent gamma-carboxylase - Candidatus
Nitrosopumilus maritimus SCM1
Length = 415
Score = 35.5 bits (78), Expect = 1.7
Identities = 20/49 (40%), Positives = 28/49 (57%), Gaps = 1/49 (2%)
Frame = +3
Query: 402 VSVHFVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLI-RFHIEKNP 545
VS H + + FS+GIF PW +IF TL+F S ++ RF + K P
Sbjct: 211 VSFHLLNAQLFSIGIF----PWFMIFATLIFFVPSWPRVLKRFKVAKKP 255
>UniRef50_Q19127 Cluster: Niemann-Pick C1 protein homolog 1
precursor; n=2; Caenorhabditis|Rep: Niemann-Pick C1
protein homolog 1 precursor - Caenorhabditis elegans
Length = 1383
Score = 35.5 bits (78), Expect = 1.7
Identities = 30/132 (22%), Positives = 60/132 (45%), Gaps = 13/132 (9%)
Frame = +3
Query: 411 HFVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEK-NPMNLWVPPDSDFYHD 587
+F+E+ +G+ ++P F V + C+ + +H E N +++W P S +
Sbjct: 336 NFMENNARDIGMMAGRNPKSHFFIGCA-VLIFCLPGMIYHKESTNVVDMWSSPRSRARQE 394
Query: 588 TNWYIKTFGTGLRLQNIIFTAN-----------DVLHPDVLIEINDITEKISALNVK-YE 731
+ FG R Q I+ ++ V H D+ E+ DI I ++ + +
Sbjct: 395 EMVFNANFGRPQRYQQIMLLSHRDFQSSGKLYGPVFHKDIFEELFDILNAIKNISTQDSD 454
Query: 732 NQSISLTDLCYK 767
++I+L D+CY+
Sbjct: 455 GRTITLDDVCYR 466
>UniRef50_Q8NRN1 Cluster: Acyl-CoA dehydrogenases; n=1;
Corynebacterium glutamicum|Rep: Acyl-CoA dehydrogenases
- Corynebacterium glutamicum (Brevibacterium flavum)
Length = 399
Score = 35.1 bits (77), Expect = 2.2
Identities = 14/36 (38%), Positives = 22/36 (61%)
Frame = -2
Query: 773 RNFVTQISKRNGLIFILNI*GTYFFSNIVYFYEYIW 666
+ F+ ++ NG IF+LN GT F++ YF +Y W
Sbjct: 126 QTFIDEVETENGPIFVLN--GTKFYTTGTYFADYTW 159
>UniRef50_Q8D273 Cluster: YtfN protein; n=1; Wigglesworthia
glossinidia endosymbiont of Glossina brevipalpis|Rep:
YtfN protein - Wigglesworthia glossinidia brevipalpis
Length = 749
Score = 34.7 bits (76), Expect = 2.9
Identities = 18/64 (28%), Positives = 35/64 (54%)
Frame = +3
Query: 567 DSDFYHDTNWYIKTFGTGLRLQNIIFTANDVLHPDVLIEINDITEKISALNVKYENQSIS 746
+S+ Y D N K F + + I+T N+ L+ ++L +I D+ I + +KY N ++
Sbjct: 38 NSNIYFDFNLLSKNFYGKINGKIFIYTKNNELNANLLFKIKDLV--IKDIKIKYSNIQLN 95
Query: 747 LTDL 758
+ +L
Sbjct: 96 INEL 99
>UniRef50_A7SH24 Cluster: Predicted protein; n=5; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 881
Score = 34.7 bits (76), Expect = 2.9
Identities = 21/61 (34%), Positives = 27/61 (44%), Gaps = 1/61 (1%)
Frame = +3
Query: 408 VHFVESIFFS-LGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYH 584
+H FF +G VA +PW I L V G IRF +E L++P DS
Sbjct: 1 MHEYTGRFFGFIGSKVATYPWITICICLTVVGGLACGFIRFKVENRTEKLYIPQDSQAIK 60
Query: 585 D 587
D
Sbjct: 61 D 61
>UniRef50_Q5TJ79 Cluster: Putative uncharacterized protein; n=2;
Sulfolobus islandicus rod-shaped virus 1|Rep: Putative
uncharacterized protein - Sulfolobus islandicus
rudivirus 1 variant XX
Length = 241
Score = 34.3 bits (75), Expect = 3.9
Identities = 16/52 (30%), Positives = 30/52 (57%)
Frame = +3
Query: 630 QNIIFTANDVLHPDVLIEINDITEKISALNVKYENQSISLTDLCYKVPVVNF 785
Q I ND+ + ++++ ++ K S++ +KY+N SI L D+ YK + F
Sbjct: 83 QKIFRKINDIKSMLINLDLSKVSLKSSSIIIKYDNYSIQLFDIYYKGEKLEF 134
>UniRef50_Q2FPB2 Cluster: Hydrophobe/amphiphile efflux-3 HAE3
precursor; n=1; Methanospirillum hungatei JF-1|Rep:
Hydrophobe/amphiphile efflux-3 HAE3 precursor -
Methanospirillum hungatei (strain JF-1 / DSM 864)
Length = 747
Score = 34.3 bits (75), Expect = 3.9
Identities = 31/117 (26%), Positives = 52/117 (44%), Gaps = 3/117 (2%)
Frame = +3
Query: 417 VESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIE---KNPMNLWVPPDSDFYHD 587
+ SIF S+ V P V+ L S +G+ ++ + ++ P F H
Sbjct: 1 MRSIFESISSLVVNRPKLVLGALCLIFIASIVGMSMLKMQTGNETYLDKNTPKGIAFSH- 59
Query: 588 TNWYIKTFGTGLRLQNIIFTANDVLHPDVLIEINDITEKISALNVKYENQSISLTDL 758
Y TF + I+ +ND L+PDV+ ++ IT + N++Y N S+ DL
Sbjct: 60 ---YEDTFSQDTLV--ILIESNDPLNPDVIAYLDKITPGLK--NLQYINSVSSIADL 109
>UniRef50_UPI00015B5B2F Cluster: PREDICTED: similar to putative
hedgehog receptor; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to putative hedgehog receptor -
Nasonia vitripennis
Length = 1791
Score = 33.9 bits (74), Expect = 5.1
Identities = 28/124 (22%), Positives = 54/124 (43%), Gaps = 8/124 (6%)
Frame = +3
Query: 438 LGIFVAKHPWQVIFGTLLFVTVSCIGL--IRFHIEKNPMNLWVPPDSDFYHDTNWYIKTF 611
LG F+ ++ +V+F + + +GL ++FH + + LW+ ++ + T
Sbjct: 586 LGYFLYRNAGKVLFVAICVLAAISLGLRAVQFHTKVD--QLWIQEGGRLENELRYIADTV 643
Query: 612 G-TGLRLQNIIFTAN-----DVLHPDVLIEINDITEKISALNVKYENQSISLTDLCYKVP 773
G T ++ A ++LH L E + + + V + S +L DLCYK
Sbjct: 644 GETPASTHQLVIQAPKHHGANILHTAALKEHLAVLRNATQVTVSLFDTSWTLKDLCYKPS 703
Query: 774 VVNF 785
+ F
Sbjct: 704 IPMF 707
>UniRef50_UPI0000E48C80 Cluster: PREDICTED: similar to Fbxw9
protein; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to Fbxw9 protein - Strongylocentrotus
purpuratus
Length = 810
Score = 33.9 bits (74), Expect = 5.1
Identities = 18/68 (26%), Positives = 31/68 (45%)
Frame = +3
Query: 417 VESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTNW 596
+++ F+LG ++ H + +F L+ + +GL IE N LWV + +
Sbjct: 435 LQAFLFTLGCYLQLHCGKALFLGLVILGAFAVGLKLTKIETNVEKLWVQVGGRLEQELEY 494
Query: 597 YIKTFGTG 620
T GTG
Sbjct: 495 TEATLGTG 502
>UniRef50_Q4RVD6 Cluster: Chromosome 15 SCAF14992, whole genome
shotgun sequence; n=3; Euteleostomi|Rep: Chromosome 15
SCAF14992, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 1197
Score = 33.9 bits (74), Expect = 5.1
Identities = 30/130 (23%), Positives = 58/130 (44%), Gaps = 9/130 (6%)
Frame = +3
Query: 417 VESIFFSLGIFVAKHPWQVIF-GTLLFVTVSCIGLIRFHIEKNPMNLWVPPDS------D 575
++++ F+LG ++ +H +V+F G L+F +S +GL IE N LWV S
Sbjct: 10 LQALLFTLGCYIQRHCGKVLFIGLLVFGALS-VGLRVATIETNIEKLWVKSGSRVSTELQ 68
Query: 576 FYHDTNWYIKTFGTGLRLQNIIFTANDVLHPDVLIEINDITEKISALNVKYENQSISLTD 755
+ + F + + +Q ++L + + S + V ++ L
Sbjct: 69 YTREKQGEDAVFTSQMLIQTPKEKGANILTQEAFLVHMKAALSASEIKVSLFGKTWDLNK 128
Query: 756 LCYK--VPVV 779
+CYK VP++
Sbjct: 129 ICYKSGVPII 138
>UniRef50_UPI0000D55472 Cluster: PREDICTED: similar to Patched
protein (Hedgehog receptor); n=1; Tribolium
castaneum|Rep: PREDICTED: similar to Patched protein
(Hedgehog receptor) - Tribolium castaneum
Length = 1175
Score = 33.5 bits (73), Expect = 6.8
Identities = 25/117 (21%), Positives = 48/117 (41%)
Frame = +3
Query: 435 SLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTNWYIKTFG 614
SLG + H + +F ++L + +GL + LW P + + T
Sbjct: 57 SLGRILDTHAGKFLFVSVLAIATFSVGLKSMAFHSDIELLWAEPSTGAEATPQEMLSTHQ 116
Query: 615 TGLRLQNIIFTANDVLHPDVLIEINDITEKISALNVKYENQSISLTDLCYKVPVVNF 785
+ +Q + D+LHP L+E + +K + + + + + L D C + NF
Sbjct: 117 --MIVQTAVEPDIDLLHPHGLLEHLALLQKATQVTITMFDITWRLKDFCQAPSIPNF 171
>UniRef50_O44978 Cluster: Patched related family protein 11; n=2;
Caenorhabditis|Rep: Patched related family protein 11 -
Caenorhabditis elegans
Length = 820
Score = 33.5 bits (73), Expect = 6.8
Identities = 23/94 (24%), Positives = 46/94 (48%), Gaps = 6/94 (6%)
Frame = +3
Query: 450 VAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTNWYIKTFGTGLRL 629
+A +P I ++L + V GL+ +E + + P DSD ++T +++ +G +
Sbjct: 14 LAAYPVYSILLSILSILVLSSGLVHIRLEPDIRKAFSPDDSDAGYETRVWLEYYGLDIYP 73
Query: 630 QN--IIFTA----NDVLHPDVLIEINDITEKISA 713
+ IFTA + +L L +I + ++SA
Sbjct: 74 ERAFCIFTAKRENSSILQEGALADIYTVDNRLSA 107
>UniRef50_A7F1R8 Cluster: Putative uncharacterized protein; n=1;
Sclerotinia sclerotiorum 1980|Rep: Putative
uncharacterized protein - Sclerotinia sclerotiorum 1980
Length = 412
Score = 33.5 bits (73), Expect = 6.8
Identities = 9/29 (31%), Positives = 19/29 (65%)
Frame = +3
Query: 516 LIRFHIEKNPMNLWVPPDSDFYHDTNWYI 602
++RF++ P N W P+S++ + T W++
Sbjct: 321 IVRFNVTIEPENAWTSPNSNYTYQTRWFL 349
>UniRef50_Q6MP63 Cluster: Acriflavin resistance protein; n=2;
Bdellovibrio bacteriovorus|Rep: Acriflavin resistance
protein - Bdellovibrio bacteriovorus
Length = 1050
Score = 33.1 bits (72), Expect = 9.0
Identities = 13/30 (43%), Positives = 21/30 (70%)
Frame = +3
Query: 456 KHPWQVIFGTLLFVTVSCIGLIRFHIEKNP 545
+HPW+V+ G+L+FV VS I + + E +P
Sbjct: 529 QHPWKVLIGSLVFVAVSFISIKFLNKEMSP 558
>UniRef50_Q54N25 Cluster: Putative uncharacterized protein; n=1;
Dictyostelium discoideum AX4|Rep: Putative
uncharacterized protein - Dictyostelium discoideum AX4
Length = 762
Score = 33.1 bits (72), Expect = 9.0
Identities = 19/62 (30%), Positives = 28/62 (45%)
Frame = +3
Query: 573 DFYHDTNWYIKTFGTGLRLQNIIFTANDVLHPDVLIEINDITEKISALNVKYENQSISLT 752
D Y NW +KT+G L+ I N+ + + + IN I+ I N K S+
Sbjct: 111 DNYEILNWLLKTYGKTYILEYIKNNINNDIEEPLQVFINSISSNIYLANPKSSESLESII 170
Query: 753 DL 758
DL
Sbjct: 171 DL 172
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 792,667,259
Number of Sequences: 1657284
Number of extensions: 16297231
Number of successful extensions: 39691
Number of sequences better than 10.0: 58
Number of HSP's better than 10.0 without gapping: 38071
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 39651
length of database: 575,637,011
effective HSP length: 100
effective length of database: 409,908,611
effective search space used: 73783549980
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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