Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fcaL-P15_F_I08
(843 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
BC063302-1|AAH63302.1| 1278|Homo sapiens Niemann-Pick disease, t... 52 3e-06
AF338230-1|AAK25791.1| 1278|Homo sapiens Niemann-Pick disease C1... 52 3e-06
AF157379-1|AAD48006.1| 1278|Homo sapiens Niemann-Pick C1 protein... 52 3e-06
AF002020-1|AAB63982.1| 1278|Homo sapiens Niemann-Pick C disease ... 52 3e-06
AB209048-1|BAD92285.1| 1289|Homo sapiens Niemann-Pick disease, t... 52 3e-06
BC117178-1|AAI17179.1| 1332|Homo sapiens NPC1L1 protein protein. 44 0.001
AY515256-1|AAS56939.1| 1332|Homo sapiens NPC1L1 splice variant p... 44 0.001
AY437865-1|AAR97886.1| 1332|Homo sapiens Niemann-Pick C1-like 1 ... 44 0.001
AF192523-1|AAF20397.1| 724|Homo sapiens truncated Niemann-Pick ... 44 0.001
AF192522-1|AAF20396.1| 1359|Homo sapiens Niemann-Pick C1-like pr... 44 0.001
AF087651-1|AAD25953.1| 1203|Homo sapiens patched 2 protein. 38 0.034
AY438664-1|AAR05447.1| 1203|Homo sapiens patched homolog 2 (Dros... 38 0.046
AY359016-1|AAQ89375.1| 1203|Homo sapiens Patched 2 protein. 38 0.046
AY358555-1|AAQ88919.1| 1211|Homo sapiens Patched 2 protein. 38 0.046
AL592166-5|CAI13000.1| 1203|Homo sapiens patched homolog 2 (Dros... 38 0.046
AL136380-1|CAI23127.1| 1203|Homo sapiens patched homolog 2 (Dros... 38 0.046
AF119569-1|AAD17260.1| 1146|Homo sapiens patched 2 protein. 38 0.046
AF091501-1|AAC79847.1| 1203|Homo sapiens receptor protein patche... 38 0.046
U59464-1|AAC50550.1| 1447|Homo sapiens PATCHED protein. 38 0.060
AL161729-1|CAH73817.1| 1447|Homo sapiens patched homolog 1 (Dros... 38 0.060
BC043542-1|AAH43542.1| 183|Homo sapiens PTCH1 protein protein. 36 0.18
AB189437-1|BAD74185.1| 324|Homo sapiens tumor suppressor patche... 36 0.18
AB189436-1|BAD74184.1| 259|Homo sapiens tumor suppressor patche... 36 0.18
M11058-1|AAA52679.1| 888|Homo sapiens HMGCR protein. 32 2.3
BC033692-1|AAH33692.1| 835|Homo sapiens HMGCR protein protein. 32 2.3
AY321356-1|AAP72015.1| 888|Homo sapiens 3-hydroxy-3-methylgluta... 32 2.3
AF273765-1|AAG21343.1| 888|Homo sapiens 3-hydroxy-3-methylgluta... 32 2.3
BC084553-1|AAH84553.1| 371|Homo sapiens glutamate receptor, ion... 30 9.1
BC041788-1|AAH41788.2| 371|Homo sapiens glutamate receptor, ion... 30 9.1
AB097026-1|BAC77379.1| 371|Homo sapiens putative MAPK activatin... 30 9.1
>BC063302-1|AAH63302.1| 1278|Homo sapiens Niemann-Pick disease, type
C1 protein.
Length = 1278
Score = 51.6 bits (118), Expect = 3e-06
Identities = 36/142 (25%), Positives = 65/142 (45%), Gaps = 19/142 (13%)
Frame = +3
Query: 393 VSSVSVHFVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDS 572
VS+ + +F G F ++P VIF +L+F+T GL+ + NP++LW P S
Sbjct: 327 VSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSS 386
Query: 573 DFYHDTNWYIKTFGTGLRLQNIIFTA--------------NDV-----LHPDVLIEINDI 695
+ ++ + FG R + +I A DV L +L ++ D+
Sbjct: 387 QARLEKEYFDQHFGPFFRTEQLIIRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDL 446
Query: 696 TEKISALNVKYENQSISLTDLC 761
I + Y+N++++L D+C
Sbjct: 447 QIAIENITASYDNETVTLQDIC 468
>AF338230-1|AAK25791.1| 1278|Homo sapiens Niemann-Pick disease C1
protein protein.
Length = 1278
Score = 51.6 bits (118), Expect = 3e-06
Identities = 36/142 (25%), Positives = 65/142 (45%), Gaps = 19/142 (13%)
Frame = +3
Query: 393 VSSVSVHFVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDS 572
VS+ + +F G F ++P VIF +L+F+T GL+ + NP++LW P S
Sbjct: 327 VSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSS 386
Query: 573 DFYHDTNWYIKTFGTGLRLQNIIFTA--------------NDV-----LHPDVLIEINDI 695
+ ++ + FG R + +I A DV L +L ++ D+
Sbjct: 387 QARLEKEYFDQHFGPFFRTEQLIIRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDL 446
Query: 696 TEKISALNVKYENQSISLTDLC 761
I + Y+N++++L D+C
Sbjct: 447 QIAIENITASYDNETVTLQDIC 468
>AF157379-1|AAD48006.1| 1278|Homo sapiens Niemann-Pick C1 protein
protein.
Length = 1278
Score = 51.6 bits (118), Expect = 3e-06
Identities = 36/142 (25%), Positives = 65/142 (45%), Gaps = 19/142 (13%)
Frame = +3
Query: 393 VSSVSVHFVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDS 572
VS+ + +F G F ++P VIF +L+F+T GL+ + NP++LW P S
Sbjct: 327 VSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSS 386
Query: 573 DFYHDTNWYIKTFGTGLRLQNIIFTA--------------NDV-----LHPDVLIEINDI 695
+ ++ + FG R + +I A DV L +L ++ D+
Sbjct: 387 QARLEKEYFDQHFGPFFRTEQLIIRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDL 446
Query: 696 TEKISALNVKYENQSISLTDLC 761
I + Y+N++++L D+C
Sbjct: 447 QIAIENITASYDNETVTLQDIC 468
>AF002020-1|AAB63982.1| 1278|Homo sapiens Niemann-Pick C disease
protein protein.
Length = 1278
Score = 51.6 bits (118), Expect = 3e-06
Identities = 36/142 (25%), Positives = 65/142 (45%), Gaps = 19/142 (13%)
Frame = +3
Query: 393 VSSVSVHFVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDS 572
VS+ + +F G F ++P VIF +L+F+T GL+ + NP++LW P S
Sbjct: 327 VSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSS 386
Query: 573 DFYHDTNWYIKTFGTGLRLQNIIFTA--------------NDV-----LHPDVLIEINDI 695
+ ++ + FG R + +I A DV L +L ++ D+
Sbjct: 387 QARLEKEYFDQHFGPFFRTEQLIIRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDL 446
Query: 696 TEKISALNVKYENQSISLTDLC 761
I + Y+N++++L D+C
Sbjct: 447 QIAIENITASYDNETVTLQDIC 468
>AB209048-1|BAD92285.1| 1289|Homo sapiens Niemann-Pick disease, type
C1 variant protein.
Length = 1289
Score = 51.6 bits (118), Expect = 3e-06
Identities = 36/142 (25%), Positives = 65/142 (45%), Gaps = 19/142 (13%)
Frame = +3
Query: 393 VSSVSVHFVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDS 572
VS+ + +F G F ++P VIF +L+F+T GL+ + NP++LW P S
Sbjct: 338 VSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSS 397
Query: 573 DFYHDTNWYIKTFGTGLRLQNIIFTA--------------NDV-----LHPDVLIEINDI 695
+ ++ + FG R + +I A DV L +L ++ D+
Sbjct: 398 QARLEKEYFDQHFGPFFRTEQLIIRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDL 457
Query: 696 TEKISALNVKYENQSISLTDLC 761
I + Y+N++++L D+C
Sbjct: 458 QIAIENITASYDNETVTLQDIC 479
>BC117178-1|AAI17179.1| 1332|Homo sapiens NPC1L1 protein protein.
Length = 1332
Score = 43.6 bits (98), Expect = 0.001
Identities = 36/143 (25%), Positives = 65/143 (45%), Gaps = 21/143 (14%)
Frame = +3
Query: 399 SVSVHFVESIFFS-LGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSD 575
S S H + FF G +VA P ++ +++ V GL+ + +P+ LW P+S
Sbjct: 330 SFSTHTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQ 389
Query: 576 FYHDTNWYIKTFGTGLRLQNIIFTA------------------NDVLHPDVLIEINDITE 701
+ ++ + FG R +I TA + +L D+L+E+ ++ E
Sbjct: 390 ARSEKAFHDQHFGPFFRTNQVILTAPNRSSYRYDSLLLGPKNFSGILDLDLLLELLELQE 449
Query: 702 KISALNV--KYENQSISLTDLCY 764
++ L V ++ISL D+CY
Sbjct: 450 RLRHLQVWSPEAQRNISLQDICY 472
>AY515256-1|AAS56939.1| 1332|Homo sapiens NPC1L1 splice variant
protein.
Length = 1332
Score = 43.6 bits (98), Expect = 0.001
Identities = 36/143 (25%), Positives = 65/143 (45%), Gaps = 21/143 (14%)
Frame = +3
Query: 399 SVSVHFVESIFFS-LGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSD 575
S S H + FF G +VA P ++ +++ V GL+ + +P+ LW P+S
Sbjct: 330 SFSTHTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQ 389
Query: 576 FYHDTNWYIKTFGTGLRLQNIIFTA------------------NDVLHPDVLIEINDITE 701
+ ++ + FG R +I TA + +L D+L+E+ ++ E
Sbjct: 390 ARSEKAFHDQHFGPFFRTNQVILTAPNRSSYRYDSLLLGPKNFSGILDLDLLLELLELQE 449
Query: 702 KISALNV--KYENQSISLTDLCY 764
++ L V ++ISL D+CY
Sbjct: 450 RLRHLQVWSPEAQRNISLQDICY 472
>AY437865-1|AAR97886.1| 1332|Homo sapiens Niemann-Pick C1-like 1
protein.
Length = 1332
Score = 43.6 bits (98), Expect = 0.001
Identities = 36/143 (25%), Positives = 65/143 (45%), Gaps = 21/143 (14%)
Frame = +3
Query: 399 SVSVHFVESIFFS-LGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSD 575
S S H + FF G +VA P ++ +++ V GL+ + +P+ LW P+S
Sbjct: 330 SFSTHTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQ 389
Query: 576 FYHDTNWYIKTFGTGLRLQNIIFTA------------------NDVLHPDVLIEINDITE 701
+ ++ + FG R +I TA + +L D+L+E+ ++ E
Sbjct: 390 ARSEKAFHDQHFGPFFRTNQVILTAPNRSSYRYDSLLLGPKNFSGILDLDLLLELLELQE 449
Query: 702 KISALNV--KYENQSISLTDLCY 764
++ L V ++ISL D+CY
Sbjct: 450 RLRHLQVWSPEAQRNISLQDICY 472
>AF192523-1|AAF20397.1| 724|Homo sapiens truncated Niemann-Pick
C1-like protein 1 protein.
Length = 724
Score = 43.6 bits (98), Expect = 0.001
Identities = 36/143 (25%), Positives = 65/143 (45%), Gaps = 21/143 (14%)
Frame = +3
Query: 399 SVSVHFVESIFFS-LGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSD 575
S S H + FF G +VA P ++ +++ V GL+ + +P+ LW P+S
Sbjct: 330 SFSTHTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQ 389
Query: 576 FYHDTNWYIKTFGTGLRLQNIIFTA------------------NDVLHPDVLIEINDITE 701
+ ++ + FG R +I TA + +L D+L+E+ ++ E
Sbjct: 390 ARSEKAFHDQHFGPFFRTNQVILTAPNRSSYRYDSLLLGPKNFSGILDLDLLLELLELQE 449
Query: 702 KISALNV--KYENQSISLTDLCY 764
++ L V ++ISL D+CY
Sbjct: 450 RLRHLQVWSPEAQRNISLQDICY 472
>AF192522-1|AAF20396.1| 1359|Homo sapiens Niemann-Pick C1-like
protein 1 protein.
Length = 1359
Score = 43.6 bits (98), Expect = 0.001
Identities = 36/143 (25%), Positives = 65/143 (45%), Gaps = 21/143 (14%)
Frame = +3
Query: 399 SVSVHFVESIFFS-LGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSD 575
S S H + FF G +VA P ++ +++ V GL+ + +P+ LW P+S
Sbjct: 330 SFSTHTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQ 389
Query: 576 FYHDTNWYIKTFGTGLRLQNIIFTA------------------NDVLHPDVLIEINDITE 701
+ ++ + FG R +I TA + +L D+L+E+ ++ E
Sbjct: 390 ARSEKAFHDQHFGPFFRTNQVILTAPNRSSYRYDSLLLGPKNFSGILDLDLLLELLELQE 449
Query: 702 KISALNV--KYENQSISLTDLCY 764
++ L V ++ISL D+CY
Sbjct: 450 RLRHLQVWSPEAQRNISLQDICY 472
>AF087651-1|AAD25953.1| 1203|Homo sapiens patched 2 protein.
Length = 1203
Score = 38.3 bits (85), Expect = 0.034
Identities = 32/130 (24%), Positives = 56/130 (43%), Gaps = 8/130 (6%)
Frame = +3
Query: 414 FVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTN 593
+ + + FSLG + +H +V+F LL +GL IE N LWV S + +
Sbjct: 39 YFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELH 98
Query: 594 WYIKTFG------TGLRLQNIIFTANDVLHPDVLIEINDITEKISALNVKYENQSISLTD 755
+ + G + + +Q + ++L P+ L S + V +S L
Sbjct: 99 YTKEKLGEEAAYTSQMLIQTALQEGENILTPEALGLHLQAALTASKVQVSLYGKSWDLNK 158
Query: 756 LCYK--VPVV 779
+CYK VP++
Sbjct: 159 ICYKSGVPLI 168
>AY438664-1|AAR05447.1| 1203|Homo sapiens patched homolog 2
(Drosophila) protein.
Length = 1203
Score = 37.9 bits (84), Expect = 0.046
Identities = 35/130 (26%), Positives = 56/130 (43%), Gaps = 8/130 (6%)
Frame = +3
Query: 414 FVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTN 593
+ + + FSLG + +H +V+F LL +GL IE N LWV S + +
Sbjct: 39 YFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELH 98
Query: 594 WYIKTFG--TGLRLQNIIFTA----NDVLHPDVLIEINDITEKISALNVKYENQSISLTD 755
+ + G Q +I TA ++L P+ L S + V +S L
Sbjct: 99 YTKEKLGEEAAYTSQMLIQTARQEGENILTPEALGLHLQAALTASKVQVSLYGKSWDLNK 158
Query: 756 LCYK--VPVV 779
+CYK VP++
Sbjct: 159 ICYKSGVPLI 168
>AY359016-1|AAQ89375.1| 1203|Homo sapiens Patched 2 protein.
Length = 1203
Score = 37.9 bits (84), Expect = 0.046
Identities = 35/130 (26%), Positives = 56/130 (43%), Gaps = 8/130 (6%)
Frame = +3
Query: 414 FVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTN 593
+ + + FSLG + +H +V+F LL +GL IE N LWV S + +
Sbjct: 39 YFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELH 98
Query: 594 WYIKTFG--TGLRLQNIIFTA----NDVLHPDVLIEINDITEKISALNVKYENQSISLTD 755
+ + G Q +I TA ++L P+ L S + V +S L
Sbjct: 99 YTKEKLGEEAAYTSQMLIQTARQEGENILTPEALGLHLQAALTASKVQVSLYGKSWDLNK 158
Query: 756 LCYK--VPVV 779
+CYK VP++
Sbjct: 159 ICYKSGVPLI 168
>AY358555-1|AAQ88919.1| 1211|Homo sapiens Patched 2 protein.
Length = 1211
Score = 37.9 bits (84), Expect = 0.046
Identities = 35/130 (26%), Positives = 56/130 (43%), Gaps = 8/130 (6%)
Frame = +3
Query: 414 FVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTN 593
+ + + FSLG + +H +V+F LL +GL IE N LWV S + +
Sbjct: 39 YFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELH 98
Query: 594 WYIKTFG--TGLRLQNIIFTA----NDVLHPDVLIEINDITEKISALNVKYENQSISLTD 755
+ + G Q +I TA ++L P+ L S + V +S L
Sbjct: 99 YTKEKLGEEAAYTSQMLIQTARQEGENILTPEALGLHLQAALTASKVQVSLYGKSWDLNK 158
Query: 756 LCYK--VPVV 779
+CYK VP++
Sbjct: 159 ICYKSGVPLI 168
>AL592166-5|CAI13000.1| 1203|Homo sapiens patched homolog 2
(Drosophila) protein.
Length = 1203
Score = 37.9 bits (84), Expect = 0.046
Identities = 35/130 (26%), Positives = 56/130 (43%), Gaps = 8/130 (6%)
Frame = +3
Query: 414 FVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTN 593
+ + + FSLG + +H +V+F LL +GL IE N LWV S + +
Sbjct: 39 YFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELH 98
Query: 594 WYIKTFG--TGLRLQNIIFTA----NDVLHPDVLIEINDITEKISALNVKYENQSISLTD 755
+ + G Q +I TA ++L P+ L S + V +S L
Sbjct: 99 YTKEKLGEEAAYTSQMLIQTARQEGENILTPEALGLHLQAALTASKVQVSLYGKSWDLNK 158
Query: 756 LCYK--VPVV 779
+CYK VP++
Sbjct: 159 ICYKSGVPLI 168
>AL136380-1|CAI23127.1| 1203|Homo sapiens patched homolog 2
(Drosophila) protein.
Length = 1203
Score = 37.9 bits (84), Expect = 0.046
Identities = 35/130 (26%), Positives = 56/130 (43%), Gaps = 8/130 (6%)
Frame = +3
Query: 414 FVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTN 593
+ + + FSLG + +H +V+F LL +GL IE N LWV S + +
Sbjct: 39 YFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELH 98
Query: 594 WYIKTFG--TGLRLQNIIFTA----NDVLHPDVLIEINDITEKISALNVKYENQSISLTD 755
+ + G Q +I TA ++L P+ L S + V +S L
Sbjct: 99 YTKEKLGEEAAYTSQMLIQTARQEGENILTPEALGLHLQAALTASKVQVSLYGKSWDLNK 158
Query: 756 LCYK--VPVV 779
+CYK VP++
Sbjct: 159 ICYKSGVPLI 168
>AF119569-1|AAD17260.1| 1146|Homo sapiens patched 2 protein.
Length = 1146
Score = 37.9 bits (84), Expect = 0.046
Identities = 35/130 (26%), Positives = 56/130 (43%), Gaps = 8/130 (6%)
Frame = +3
Query: 414 FVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTN 593
+ + + FSLG + +H +V+F LL +GL IE N LWV S + +
Sbjct: 39 YFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELH 98
Query: 594 WYIKTFG--TGLRLQNIIFTA----NDVLHPDVLIEINDITEKISALNVKYENQSISLTD 755
+ + G Q +I TA ++L P+ L S + V +S L
Sbjct: 99 YTKEKLGEEAAYTSQMLIQTARQEGENILTPEALGLHLQAALTASKVQVSLYGKSWDLNK 158
Query: 756 LCYK--VPVV 779
+CYK VP++
Sbjct: 159 ICYKSGVPLI 168
>AF091501-1|AAC79847.1| 1203|Homo sapiens receptor protein patched 2
protein.
Length = 1203
Score = 37.9 bits (84), Expect = 0.046
Identities = 35/130 (26%), Positives = 56/130 (43%), Gaps = 8/130 (6%)
Frame = +3
Query: 414 FVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTN 593
+ + + FSLG + +H +V+F LL +GL IE N LWV S + +
Sbjct: 39 YFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELH 98
Query: 594 WYIKTFG--TGLRLQNIIFTA----NDVLHPDVLIEINDITEKISALNVKYENQSISLTD 755
+ + G Q +I TA ++L P+ L S + V +S L
Sbjct: 99 YTKEKLGEEAAYTSQMLIQTARQEGENILTPEALGLHLQAALTASKVQVSLYGKSWDLNK 158
Query: 756 LCYK--VPVV 779
+CYK VP++
Sbjct: 159 ICYKSGVPLI 168
>U59464-1|AAC50550.1| 1447|Homo sapiens PATCHED protein.
Length = 1447
Score = 37.5 bits (83), Expect = 0.060
Identities = 37/158 (23%), Positives = 64/158 (40%), Gaps = 6/158 (3%)
Frame = +3
Query: 312 SYSTSAVNCSKMSKKKNVKTPQQIWEGVSSVSVHFVESIFFSLGIFVAKHPWQVIFGTLL 491
SY +A ++SK K +W + F + + F LG ++ K+ + + LL
Sbjct: 54 SYCDAAFALEQISKGKATGRKAPLW-----LRAKF-QRLLFKLGCYIQKNCGKFLVVGLL 107
Query: 492 FVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTNWYIK------TFGTGLRLQNIIFTAN 653
+GL ++E N LWV + N+ + F L +Q
Sbjct: 108 IFGAFAVGLKAANLETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGA 167
Query: 654 DVLHPDVLIEINDITEKISALNVKYENQSISLTDLCYK 767
+VL + L++ D + S ++V N+ L LCYK
Sbjct: 168 NVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYK 205
>AL161729-1|CAH73817.1| 1447|Homo sapiens patched homolog 1
(Drosophila) protein.
Length = 1447
Score = 37.5 bits (83), Expect = 0.060
Identities = 37/158 (23%), Positives = 64/158 (40%), Gaps = 6/158 (3%)
Frame = +3
Query: 312 SYSTSAVNCSKMSKKKNVKTPQQIWEGVSSVSVHFVESIFFSLGIFVAKHPWQVIFGTLL 491
SY +A ++SK K +W + F + + F LG ++ K+ + + LL
Sbjct: 54 SYCDAAFALEQISKGKATGRKAPLW-----LRAKF-QRLLFKLGCYIQKNCGKFLVVGLL 107
Query: 492 FVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTNWYIK------TFGTGLRLQNIIFTAN 653
+GL ++E N LWV + N+ + F L +Q
Sbjct: 108 IFGAFAVGLKAANLETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGA 167
Query: 654 DVLHPDVLIEINDITEKISALNVKYENQSISLTDLCYK 767
+VL + L++ D + S ++V N+ L LCYK
Sbjct: 168 NVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYK 205
>BC043542-1|AAH43542.1| 183|Homo sapiens PTCH1 protein protein.
Length = 183
Score = 35.9 bits (79), Expect = 0.18
Identities = 29/122 (23%), Positives = 51/122 (41%), Gaps = 6/122 (4%)
Frame = +3
Query: 420 ESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTNWY 599
+ + F LG ++ K+ + + LL +GL ++E N LWV + N+
Sbjct: 18 QRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEELWVEVGGRVSRELNYT 77
Query: 600 IK------TFGTGLRLQNIIFTANDVLHPDVLIEINDITEKISALNVKYENQSISLTDLC 761
+ F L +Q +VL + L++ D + S ++V N+ L LC
Sbjct: 78 RQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLC 137
Query: 762 YK 767
YK
Sbjct: 138 YK 139
>AB189437-1|BAD74185.1| 324|Homo sapiens tumor suppressor patched
L' isoform protein.
Length = 324
Score = 35.9 bits (79), Expect = 0.18
Identities = 29/122 (23%), Positives = 51/122 (41%), Gaps = 6/122 (4%)
Frame = +3
Query: 420 ESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTNWY 599
+ + F LG ++ K+ + + LL +GL ++E N LWV + N+
Sbjct: 83 QRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEELWVEVGGRVSRELNYT 142
Query: 600 IK------TFGTGLRLQNIIFTANDVLHPDVLIEINDITEKISALNVKYENQSISLTDLC 761
+ F L +Q +VL + L++ D + S ++V N+ L LC
Sbjct: 143 RQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLC 202
Query: 762 YK 767
YK
Sbjct: 203 YK 204
>AB189436-1|BAD74184.1| 259|Homo sapiens tumor suppressor patched
medium isoform protein.
Length = 259
Score = 35.9 bits (79), Expect = 0.18
Identities = 29/122 (23%), Positives = 51/122 (41%), Gaps = 6/122 (4%)
Frame = +3
Query: 420 ESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTNWY 599
+ + F LG ++ K+ + + LL +GL ++E N LWV + N+
Sbjct: 18 QRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEELWVEVGGRVSRELNYT 77
Query: 600 IK------TFGTGLRLQNIIFTANDVLHPDVLIEINDITEKISALNVKYENQSISLTDLC 761
+ F L +Q +VL + L++ D + S ++V N+ L LC
Sbjct: 78 RQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLC 137
Query: 762 YK 767
YK
Sbjct: 138 YK 139
>M11058-1|AAA52679.1| 888|Homo sapiens HMGCR protein.
Length = 888
Score = 32.3 bits (70), Expect = 2.3
Identities = 12/21 (57%), Positives = 16/21 (76%)
Frame = +3
Query: 426 IFFSLGIFVAKHPWQVIFGTL 488
+F G+FVA HPW+VI GT+
Sbjct: 5 LFRMHGLFVASHPWEVIVGTV 25
>BC033692-1|AAH33692.1| 835|Homo sapiens HMGCR protein protein.
Length = 835
Score = 32.3 bits (70), Expect = 2.3
Identities = 12/21 (57%), Positives = 16/21 (76%)
Frame = +3
Query: 426 IFFSLGIFVAKHPWQVIFGTL 488
+F G+FVA HPW+VI GT+
Sbjct: 5 LFRMHGLFVASHPWEVIVGTV 25
>AY321356-1|AAP72015.1| 888|Homo sapiens
3-hydroxy-3-methylglutaryl-Coenzyme A reductase protein.
Length = 888
Score = 32.3 bits (70), Expect = 2.3
Identities = 12/21 (57%), Positives = 16/21 (76%)
Frame = +3
Query: 426 IFFSLGIFVAKHPWQVIFGTL 488
+F G+FVA HPW+VI GT+
Sbjct: 5 LFRMHGLFVASHPWEVIVGTV 25
>AF273765-1|AAG21343.1| 888|Homo sapiens
3-hydroxy-3-methylglutaryl-coenzyme A reductase protein.
Length = 888
Score = 32.3 bits (70), Expect = 2.3
Identities = 12/21 (57%), Positives = 16/21 (76%)
Frame = +3
Query: 426 IFFSLGIFVAKHPWQVIFGTL 488
+F G+FVA HPW+VI GT+
Sbjct: 5 LFRMHGLFVASHPWEVIVGTV 25
>BC084553-1|AAH84553.1| 371|Homo sapiens glutamate receptor,
ionotropic, N-methyl D-asparate-associated protein 1
(gluta protein.
Length = 371
Score = 30.3 bits (65), Expect = 9.1
Identities = 16/51 (31%), Positives = 28/51 (54%), Gaps = 2/51 (3%)
Frame = +3
Query: 375 QQIWEGVSSVSVHFVESIFFSL-GIFVAKHPWQVIFGTLLFVTVS-CIGLI 521
+ +W S +V F+ I S G F KHPW ++ ++L ++S +G+I
Sbjct: 195 ENVWTYYVSYAVFFISLIVLSCCGDFRRKHPWNLVALSVLTASLSYMVGMI 245
>BC041788-1|AAH41788.2| 371|Homo sapiens glutamate receptor,
ionotropic, N-methyl D-asparate-associated protein 1
(gluta protein.
Length = 371
Score = 30.3 bits (65), Expect = 9.1
Identities = 16/51 (31%), Positives = 28/51 (54%), Gaps = 2/51 (3%)
Frame = +3
Query: 375 QQIWEGVSSVSVHFVESIFFSL-GIFVAKHPWQVIFGTLLFVTVS-CIGLI 521
+ +W S +V F+ I S G F KHPW ++ ++L ++S +G+I
Sbjct: 195 ENVWTYYVSYAVFFISLIVLSCCGDFRRKHPWNLVALSVLTASLSYMVGMI 245
>AB097026-1|BAC77379.1| 371|Homo sapiens putative MAPK activating
protein protein.
Length = 371
Score = 30.3 bits (65), Expect = 9.1
Identities = 16/51 (31%), Positives = 28/51 (54%), Gaps = 2/51 (3%)
Frame = +3
Query: 375 QQIWEGVSSVSVHFVESIFFSL-GIFVAKHPWQVIFGTLLFVTVS-CIGLI 521
+ +W S +V F+ I S G F KHPW ++ ++L ++S +G+I
Sbjct: 195 ENVWTYYVSYAVFFISLIVLSCCGDFRRKHPWNLVALSVLTASLSYMVGMI 245
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 115,843,690
Number of Sequences: 237096
Number of extensions: 2502948
Number of successful extensions: 4214
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 4069
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4214
length of database: 76,859,062
effective HSP length: 89
effective length of database: 55,757,518
effective search space used: 10649685938
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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