Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fcaL-P13_F_I07
(792 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q01581 Cluster: Hydroxymethylglutaryl-CoA synthase, cyt... 354 1e-96
UniRef50_A6RGN8 Cluster: Hydroxymethylglutaryl-CoA synthase; n=3... 335 6e-91
UniRef50_Q2UKZ2 Cluster: Hydroxymethylglutaryl-CoA synthase; n=5... 327 2e-88
UniRef50_P54839 Cluster: Hydroxymethylglutaryl-CoA synthase; n=1... 314 2e-84
UniRef50_P54873 Cluster: Hydroxymethylglutaryl-CoA synthase; n=3... 305 1e-81
UniRef50_Q5KJX0 Cluster: Hydroxymethylglutaryl-CoA synthase, put... 287 2e-76
UniRef50_UPI00006CFE45 Cluster: hydroxymethylglutaryl-CoA syntha... 276 4e-73
UniRef50_A0DKI0 Cluster: Chromosome undetermined scaffold_54, wh... 265 1e-69
UniRef50_P54871 Cluster: Hydroxymethylglutaryl-CoA synthase; n=2... 245 1e-63
UniRef50_A2FZ93 Cluster: Hydroxymethylglutaryl-CoA synthase fami... 235 1e-60
UniRef50_Q5BWB2 Cluster: SJCHGC04979 protein; n=1; Schistosoma j... 232 9e-60
UniRef50_UPI00005A343B Cluster: PREDICTED: similar to Hydroxymet... 214 2e-54
UniRef50_Q8SR61 Cluster: 3-HYDROXY-3-METHYLGLUTARYL-CoA SYNTHASE... 184 2e-45
UniRef50_Q7QQE4 Cluster: GLP_91_15470_16939; n=1; Giardia lambli... 148 1e-34
UniRef50_Q1D4I1 Cluster: Hydroxymethylglutaryl-CoA synthase; n=2... 145 1e-33
UniRef50_A0RW92 Cluster: 3-hydroxy-3-methylglutaryl CoA synthase... 122 1e-26
UniRef50_Q5V1G0 Cluster: Hydroxymethylglutaryl-CoA synthase; n=5... 114 3e-24
UniRef50_Q9FD82 Cluster: HMG-CoA synthase; n=16; Staphylococcus|... 99 1e-19
UniRef50_A5EUV4 Cluster: Hydroxymethylglutaryl-CoA synthase; n=1... 97 3e-19
UniRef50_A0NJ77 Cluster: 3-hydroxy-3-methylglutaryl CoA synthase... 97 6e-19
UniRef50_Q88VI4 Cluster: Hydroxymethylglutaryl-CoA synthase; n=4... 93 5e-18
UniRef50_A5FM54 Cluster: Hydroxymethylglutaryl-CoA synthase; n=2... 91 2e-17
UniRef50_Q8L1I3 Cluster: HMG-CoA synthase; n=1; Paracoccus zeaxa... 89 1e-16
UniRef50_Q9FD56 Cluster: HMG-CoA synthase; n=46; Streptococcacea... 84 4e-15
UniRef50_Q04AW0 Cluster: 3-hydroxy-3-methylglutaryl CoA synthase... 83 6e-15
UniRef50_A4FIG4 Cluster: Hydroxymethylglutaryl-CoA synthase; n=1... 78 3e-13
UniRef50_A7QFV6 Cluster: Chromosome undetermined scaffold_89, wh... 74 5e-12
UniRef50_Q767G7 Cluster: HMG-CoA synthase; n=9; Bacteria|Rep: HM... 72 2e-11
UniRef50_P40830 Cluster: Putative polyketide biosynthesis protei... 66 1e-09
UniRef50_A6G789 Cluster: Hydroxymethylglutaryl-CoA synthase; n=1... 64 4e-09
UniRef50_A6G7N7 Cluster: Hydroxymethylglutaryl-coenzyme A syntha... 64 5e-09
UniRef50_Q4QAB9 Cluster: Putative uncharacterized protein; n=5; ... 62 2e-08
UniRef50_UPI000038D51C Cluster: COG3425: 3-hydroxy-3-methylgluta... 59 1e-07
UniRef50_Q7LZE7 Cluster: Hydroxymethylglutaryl-CoA synthase; n=2... 57 4e-07
UniRef50_Q1CGN1 Cluster: Hydroxymethylglutaryl-coenzyme A syntha... 53 9e-06
UniRef50_Q6MLJ5 Cluster: 3-oxoacyl-(Acyl-carrier-protein) syntha... 44 0.004
UniRef50_P51196 Cluster: 3-oxoacyl-[acyl-carrier-protein] syntha... 43 0.010
UniRef50_Q81JG0 Cluster: 3-oxoacyl-[acyl-carrier-protein] syntha... 40 0.072
UniRef50_Q1VIJ1 Cluster: 3-hydroxy-3-methylglutaryl-coenzyme A s... 40 0.095
UniRef50_Q97CG9 Cluster: UPF0219 protein TV0132; n=37; cellular ... 40 0.095
UniRef50_A2Z2A6 Cluster: Putative uncharacterized protein; n=2; ... 36 1.2
UniRef50_Q9KET5 Cluster: 3-oxoacyl-[acyl-carrier-protein] syntha... 36 1.5
UniRef50_Q13PK8 Cluster: Putative uncharacterized protein; n=2; ... 35 2.0
UniRef50_A4F133 Cluster: Putative uncharacterized protein; n=1; ... 35 2.0
UniRef50_UPI0000D5795B Cluster: PREDICTED: similar to CG12149-PA... 34 4.7
UniRef50_Q419Z7 Cluster: Beta-ketoacyl-acyl carrier protein synt... 33 6.2
UniRef50_Q5ATB6 Cluster: Putative uncharacterized protein; n=1; ... 33 6.2
UniRef50_UPI0000E4A4E5 Cluster: PREDICTED: similar to scavenger ... 33 8.2
UniRef50_Q8EY21 Cluster: NADH dehydrogenase; n=4; Leptospira|Rep... 33 8.2
UniRef50_A7LTP0 Cluster: Putative uncharacterized protein; n=1; ... 33 8.2
UniRef50_A4AX52 Cluster: Putative ABC-type transport system, ATP... 33 8.2
UniRef50_A3TWG2 Cluster: Methionine sulfoxide reductase B; n=1; ... 33 8.2
UniRef50_A3J8N4 Cluster: Hydrolase of the alpha/beta superfamily... 33 8.2
UniRef50_Q6K4B4 Cluster: Putative uncharacterized protein OJ1509... 33 8.2
>UniRef50_Q01581 Cluster: Hydroxymethylglutaryl-CoA synthase,
cytoplasmic; n=102; Eukaryota|Rep:
Hydroxymethylglutaryl-CoA synthase, cytoplasmic - Homo
sapiens (Human)
Length = 520
Score = 354 bits (871), Expect = 1e-96
Identities = 158/222 (71%), Positives = 192/222 (86%)
Frame = +3
Query: 126 ENVGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTALH 305
++VGI+A+E+YFPSQYVDQ ELEK+D V GKYTIGLGQ+KMGFC+DREDINS+C+T +
Sbjct: 15 KDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCTDREDINSLCMTVVQ 74
Query: 306 RLIDKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGGTA 485
L+++ ++ IGRLEVGTETIIDKSKSVKT LM LF + G TDIEGIDTTNACYGGTA
Sbjct: 75 NLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDIEGIDTTNACYGGTA 134
Query: 486 ALFNAINWVESSSWDGRKAIVVAGDIAVYGKGPARPTGGAGAVAMLIGPDAPLVFDCGVR 665
A+FNA+NW+ESSSWDGR A+VVAGDIAVY G ARPTGG GAVA+LIGP+APL+F+ G+R
Sbjct: 135 AVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALLIGPNAPLIFERGLR 194
Query: 666 ASYMTHAYDFYKPDLSSEFPYVXGKLSIQCYLNALXNCYNLF 791
++M HAYDFYKPD+ SE+P V GKLSIQCYL+AL CY+++
Sbjct: 195 GTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVY 236
>UniRef50_A6RGN8 Cluster: Hydroxymethylglutaryl-CoA synthase; n=3;
Pezizomycotina|Rep: Hydroxymethylglutaryl-CoA synthase -
Ajellomyces capsulatus NAm1
Length = 475
Score = 335 bits (824), Expect = 6e-91
Identities = 152/227 (66%), Positives = 184/227 (81%)
Frame = +3
Query: 111 MGGKVENVGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSIC 290
M + +N+GI A+E+YFPSQ VDQ ELEKFD VS GKYTIGLGQ+KM FC DREDI S+
Sbjct: 1 MPSRPQNIGIKAIEIYFPSQCVDQAELEKFDGVSQGKYTIGLGQTKMSFCDDREDIYSMS 60
Query: 291 LTALHRLIDKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNAC 470
LT L L+ K I+ IGRLEVGTETI+DKSKSVK+ LM LFA+ G T++EG+DT NAC
Sbjct: 61 LTTLSSLLRKYSIDPKSIGRLEVGTETILDKSKSVKSVLMQLFAESGNTNVEGVDTVNAC 120
Query: 471 YGGTAALFNAINWVESSSWDGRKAIVVAGDIAVYGKGPARPTGGAGAVAMLIGPDAPLVF 650
YGGT A+FN++NWVESS+WDGR AIVV GDIA+Y KG ARPTGGAG +AMLIGPDAP+VF
Sbjct: 121 YGGTNAIFNSVNWVESSAWDGRDAIVVTGDIALYKKGAARPTGGAGCIAMLIGPDAPIVF 180
Query: 651 DCGVRASYMTHAYDFYKPDLSSEFPYVXGKLSIQCYLNALXNCYNLF 791
+ G+R S++TH YDFYKPDL+SE+PYV G SI+CY A+ +CY +
Sbjct: 181 EPGLRGSHITHEYDFYKPDLTSEYPYVDGHYSIKCYTRAVDSCYKAY 227
>UniRef50_Q2UKZ2 Cluster: Hydroxymethylglutaryl-CoA synthase; n=5;
Eukaryota|Rep: Hydroxymethylglutaryl-CoA synthase -
Aspergillus oryzae
Length = 460
Score = 327 bits (803), Expect = 2e-88
Identities = 144/227 (63%), Positives = 181/227 (79%)
Frame = +3
Query: 111 MGGKVENVGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSIC 290
M + +N+G+ A+E+YFP Q V+QTELEKFD VS GKYTIGLGQ+KM FC DREDI S+
Sbjct: 1 MSARPQNIGVKAIEVYFPKQCVEQTELEKFDGVSEGKYTIGLGQTKMSFCDDREDIYSVA 60
Query: 291 LTALHRLIDKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNAC 470
LT L L K ++ +GRLEVGTET++DKSKSVK+ LM LFA+ G ++EG+D NAC
Sbjct: 61 LTTLSSLFRKYNVDPKSVGRLEVGTETLLDKSKSVKSVLMQLFAESGNFNVEGVDNVNAC 120
Query: 471 YGGTAALFNAINWVESSSWDGRKAIVVAGDIAVYGKGPARPTGGAGAVAMLIGPDAPLVF 650
YGGT A+FN+INW+ESS+WDGR A+VV GDIA+Y +GPARPTGGAG VA+LIGPDAP+VF
Sbjct: 121 YGGTNAVFNSINWLESSAWDGRDAVVVCGDIALYAEGPARPTGGAGCVALLIGPDAPIVF 180
Query: 651 DCGVRASYMTHAYDFYKPDLSSEFPYVXGKLSIQCYLNALXNCYNLF 791
+ G+R SY+TH YDFYKPDL+SE+P V G+ S+QCY A+ CY +
Sbjct: 181 EPGLRGSYVTHTYDFYKPDLTSEYPVVDGQHSLQCYTEAVDACYKAY 227
>UniRef50_P54839 Cluster: Hydroxymethylglutaryl-CoA synthase; n=11;
Ascomycota|Rep: Hydroxymethylglutaryl-CoA synthase -
Saccharomyces cerevisiae (Baker's yeast)
Length = 491
Score = 314 bits (771), Expect = 2e-84
Identities = 149/233 (63%), Positives = 179/233 (76%)
Frame = +3
Query: 93 KQYTVNMGGKVENVGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDRE 272
KQ T + +NVGI +++Y P+Q V+Q+ELEKFD VS GKYTIGLGQ+ M F +DRE
Sbjct: 36 KQKTAEQKTRPQNVGIKGIQIYIPTQCVNQSELEKFDGVSQGKYTIGLGQTNMSFVNDRE 95
Query: 273 DINSICLTALHRLIDKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGI 452
DI S+ LT L +LI I+ + IGRLEVGTET+IDKSKSVK+ LM LF + TD+EGI
Sbjct: 96 DIYSMSLTVLSKLIKSYNIDTNKIGRLEVGTETLIDKSKSVKSVLMQLFGEN--TDVEGI 153
Query: 453 DTTNACYGGTAALFNAINWVESSSWDGRKAIVVAGDIAVYGKGPARPTGGAGAVAMLIGP 632
DT NACYGGT ALFN++NW+ES++WDGR AIVV GDIA+Y KG ARPTGGAG VAM IGP
Sbjct: 154 DTLNACYGGTNALFNSLNWIESNAWDGRDAIVVCGDIAIYDKGAARPTGGAGTVAMWIGP 213
Query: 633 DAPLVFDCGVRASYMTHAYDFYKPDLSSEFPYVXGKLSIQCYLNALXNCYNLF 791
DAP+VFD VRASYM HAYDFYKPD +SE+PYV G S+ CY+ AL Y +
Sbjct: 214 DAPIVFD-SVRASYMEHAYDFYKPDFTSEYPYVDGHFSLTCYVKALDQVYKSY 265
>UniRef50_P54873 Cluster: Hydroxymethylglutaryl-CoA synthase; n=31;
Streptophytina|Rep: Hydroxymethylglutaryl-CoA synthase -
Arabidopsis thaliana (Mouse-ear cress)
Length = 461
Score = 305 bits (748), Expect = 1e-81
Identities = 139/219 (63%), Positives = 171/219 (78%)
Frame = +3
Query: 126 ENVGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTALH 305
+NVGILAM++YFP V Q LE D S GKYTIGLGQ + FC++ ED+ S+ A+
Sbjct: 3 KNVGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSFNAVT 62
Query: 306 RLIDKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGGTA 485
L +K KI+ + IGRLEVG+ET+IDKSKS+KTFLM LF K G TD+EG+D+TNACYGGTA
Sbjct: 63 SLFEKYKIDPNQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTA 122
Query: 486 ALFNAINWVESSSWDGRKAIVVAGDIAVYGKGPARPTGGAGAVAMLIGPDAPLVFDCGVR 665
AL N +NWVES+SWDGR +V+ D AVY +GPARPTGGA A+AMLIGPDAP+VF+ +R
Sbjct: 123 ALLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAIAMLIGPDAPIVFESKLR 182
Query: 666 ASYMTHAYDFYKPDLSSEFPYVXGKLSIQCYLNALXNCY 782
AS+M H YDFYKP+L+SE+P V GKLS CYL AL +CY
Sbjct: 183 ASHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCY 221
>UniRef50_Q5KJX0 Cluster: Hydroxymethylglutaryl-CoA synthase,
putative; n=2; Filobasidiella neoformans|Rep:
Hydroxymethylglutaryl-CoA synthase, putative -
Cryptococcus neoformans (Filobasidiella neoformans)
Length = 498
Score = 287 bits (704), Expect = 2e-76
Identities = 134/221 (60%), Positives = 164/221 (74%)
Frame = +3
Query: 129 NVGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTALHR 308
NVGI A+E+YFP + + + ELE FD VS GKYT+GLGQ M F D+EDINS+ LT +
Sbjct: 12 NVGIHAIEMYFPKRCISEDELEDFDGVSKGKYTLGLGQKYMAFTDDKEDINSLALTVVSN 71
Query: 309 LIDKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGGTAA 488
L+ K I+ IGRL+VGTETIIDKSKS KT LM LFA G TDIEGID+ NACYG TAA
Sbjct: 72 LLKKYNIDPRSIGRLDVGTETIIDKSKSTKTLLMDLFAASGNTDIEGIDSKNACYGSTAA 131
Query: 489 LFNAINWVESSSWDGRKAIVVAGDIAVYGKGPARPTGGAGAVAMLIGPDAPLVFDCGVRA 668
LFN +NW++S SWDGR AIV+ GDIA+Y +G ARP GG GA AMLIGPDAPLV + V
Sbjct: 132 LFNTVNWIQSESWDGRNAIVMCGDIAIYKEGGARPVGGMGACAMLIGPDAPLVLE-PVHG 190
Query: 669 SYMTHAYDFYKPDLSSEFPYVXGKLSIQCYLNALXNCYNLF 791
+Y+ + +DFYKPDL++E+P V G +I YL AL N Y+ +
Sbjct: 191 TYIANTWDFYKPDLTAEYPTVDGPWTIAAYLGALDNAYSTY 231
>UniRef50_UPI00006CFE45 Cluster: hydroxymethylglutaryl-CoA synthase
family protein; n=1; Tetrahymena thermophila SB210|Rep:
hydroxymethylglutaryl-CoA synthase family protein -
Tetrahymena thermophila SB210
Length = 566
Score = 276 bits (677), Expect = 4e-73
Identities = 133/218 (61%), Positives = 163/218 (74%), Gaps = 1/218 (0%)
Frame = +3
Query: 126 ENVGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTALH 305
+NVGI A+E YFP ++ Q ELE+FD VS GKYTIGLGQ M F ED+NS+ LT +
Sbjct: 4 QNVGIHAIETYFPKTFISQEELEQFDGVSKGKYTIGLGQKCMSFVEPYEDVNSLALTVVQ 63
Query: 306 RLIDKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGGTA 485
++K KI+ IGRLEVGTET+IDKSKS KT LM LF K G DIEGI T NACYGGTA
Sbjct: 64 NTLEKYKIDPRMIGRLEVGTETLIDKSKSTKTVLMQLFNKYGNHDIEGITTINACYGGTA 123
Query: 486 ALFNAINWVESSSWDGRK-AIVVAGDIAVYGKGPARPTGGAGAVAMLIGPDAPLVFDCGV 662
ALFN + WVESS++DG++ VV D+AVY KGPARPTGGAGA+ M+IGP+AP++ + +
Sbjct: 124 ALFNTLAWVESSAYDGKRLGCVVTVDVAVYKKGPARPTGGAGAICMIIGPNAPIIVE-PI 182
Query: 663 RASYMTHAYDFYKPDLSSEFPYVXGKLSIQCYLNALXN 776
R++++ HAYDFYKPD SEFP V G LSI YL A+ N
Sbjct: 183 RSTFIDHAYDFYKPDPRSEFPTVDGHLSINTYLGAIDN 220
>UniRef50_A0DKI0 Cluster: Chromosome undetermined scaffold_54, whole
genome shotgun sequence; n=11; Eukaryota|Rep: Chromosome
undetermined scaffold_54, whole genome shotgun sequence
- Paramecium tetraurelia
Length = 2056
Score = 265 bits (649), Expect = 1e-69
Identities = 128/220 (58%), Positives = 158/220 (71%)
Frame = +3
Query: 120 KVENVGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTA 299
K NVGI A+E+YFP YV+Q ELE FD VS GKYT+GLGQ M F ED+N++ LT
Sbjct: 2 KAINVGIEAIEIYFPKTYVNQAELELFDNVSQGKYTVGLGQVNMAFVRPFEDVNTMALTV 61
Query: 300 LHRLIDKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGG 479
+ L++K +IN IGRLEVGTE+++DKSKS KT LM LF T+IEG+ + NACYGG
Sbjct: 62 VTNLLEKNQINPALIGRLEVGTESLLDKSKSTKTTLMRLFGDN--TNIEGVTSINACYGG 119
Query: 480 TAALFNAINWVESSSWDGRKAIVVAGDIAVYGKGPARPTGGAGAVAMLIGPDAPLVFDCG 659
T ALFN INW++S +WDGR +VV DIAVY KG AR TGGAGA+AMLI P+A D
Sbjct: 120 TNALFNTINWMQSEAWDGRYGLVVCTDIAVYAKGSARTTGGAGAIAMLIAPNATFTID-P 178
Query: 660 VRASYMTHAYDFYKPDLSSEFPYVXGKLSIQCYLNALXNC 779
+R +YM YDFYKP+ SE+P V G+LSIQ YL ++ NC
Sbjct: 179 IRTTYMKDNYDFYKPNFHSEYPTVDGQLSIQSYLQSIDNC 218
>UniRef50_P54871 Cluster: Hydroxymethylglutaryl-CoA synthase; n=2;
Caenorhabditis|Rep: Hydroxymethylglutaryl-CoA synthase -
Caenorhabditis elegans
Length = 462
Score = 245 bits (599), Expect = 1e-63
Identities = 127/226 (56%), Positives = 157/226 (69%), Gaps = 3/226 (1%)
Frame = +3
Query: 123 VENVGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTAL 302
V +VGI A+ELYFP +VDQ +LEKF+ VS+GKYTIGLGQ +MGFCSD EDI SI LT
Sbjct: 11 VTDVGIGAIELYFPQNFVDQNDLEKFNNVSSGKYTIGLGQQQMGFCSDNEDIVSISLTVT 70
Query: 303 HRLIDKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGGT 482
+LI+ KI+ IG L VGTET+IDKSKSVKT LM LF G +DIEG+D NAC+GG
Sbjct: 71 RKLIETYKISTDSIGCLVVGTETMIDKSKSVKTALMDLF--PGNSDIEGVDIKNACFGGA 128
Query: 483 AALFNAINWVE-SSSWDGRKAIVVAGDIAVYGKGPARPTGGAGAVAMLIGPDAPLVFDCG 659
AL +AI+WV + D + AIVV DIA+Y +GPAR TGGAGA+A LI PDA + D
Sbjct: 129 QALLHAIDWVTVNHPLDKKNAIVVVADIAIYEEGPARCTGGAGAIAFLICPDASIPIDRQ 188
Query: 660 VRASYMTHAYDFYKP--DLSSEFPYVXGKLSIQCYLNALXNCYNLF 791
A +M + +DF+KP + SE+P V G LS+ YL A+ Y F
Sbjct: 189 FSACHMKNTWDFFKPITPIPSEYPVVDGSLSLSSYLEAVRMTYTYF 234
>UniRef50_A2FZ93 Cluster: Hydroxymethylglutaryl-CoA synthase family
protein; n=2; Trichomonas vaginalis G3|Rep:
Hydroxymethylglutaryl-CoA synthase family protein -
Trichomonas vaginalis G3
Length = 433
Score = 235 bits (574), Expect = 1e-60
Identities = 114/231 (49%), Positives = 156/231 (67%), Gaps = 9/231 (3%)
Frame = +3
Query: 126 ENVGILAMELYFPSQYVDQTELEKFD------EVST---GKYTIGLGQSKMGFCSDREDI 278
+N+GI A+++ P YV Q +LE+ + E T GK+T GLGQ+ + FC+D ED
Sbjct: 5 QNIGIKAIQVNIPRSYVTQDDLEETEISILGEESRTKIKGKFTKGLGQTALSFCTDHEDT 64
Query: 279 NSICLTALHRLIDKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDT 458
SI ++A+ +L+D D GRLE+G+ET ID+SKS+K+F+M LF + + I G+D
Sbjct: 65 ASIAMSAVQKLMDTYGYKPTDFGRLEIGSETAIDRSKSIKSFVMQLFEENHS--IMGVDN 122
Query: 459 TNACYGGTAALFNAINWVESSSWDGRKAIVVAGDIAVYGKGPARPTGGAGAVAMLIGPDA 638
TNACYGGTAA N++ W+ESS WDGR A+VV DIAVY ARPTGG GAVAM++GPDA
Sbjct: 123 TNACYGGTAAFLNSLAWIESSQWDGRLALVVCADIAVYDDRAARPTGGCGAVAMVLGPDA 182
Query: 639 PLVFDCGVRASYMTHAYDFYKPDLSSEFPYVXGKLSIQCYLNALXNCYNLF 791
P+VF+ G +Y TH++DF+KP+ ++ P V G LS+ Y L NCY F
Sbjct: 183 PIVFEKGSLTNYFTHSFDFWKPNPANPHPKVDGPLSLTLYYECLENCYMQF 233
>UniRef50_Q5BWB2 Cluster: SJCHGC04979 protein; n=1; Schistosoma
japonicum|Rep: SJCHGC04979 protein - Schistosoma
japonicum (Blood fluke)
Length = 247
Score = 232 bits (567), Expect = 9e-60
Identities = 113/176 (64%), Positives = 137/176 (77%)
Frame = +3
Query: 135 GILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTALHRLI 314
GI+A+E+YFP YV Q +LE DE GKYT GLGQ+ +GFCS +EDINSICLT + L+
Sbjct: 15 GIIALEVYFPRFYVSQHDLEVADEC-VGKYTQGLGQTSLGFCSMQEDINSICLTVVSNLV 73
Query: 315 DKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGGTAALF 494
++ I+L IG LEVGTETIIDKSKS KT LM LF G DIEG+D NAC+GGT+ALF
Sbjct: 74 KRENIDLKAIGFLEVGTETIIDKSKSTKTVLMQLFEAAGNFDIEGVDVKNACFGGTSALF 133
Query: 495 NAINWVESSSWDGRKAIVVAGDIAVYGKGPARPTGGAGAVAMLIGPDAPLVFDCGV 662
A+NW+ESS +GR A+VVA DIAVYG+ ARPTGGAGAVA+L+GP+APLV D G+
Sbjct: 134 GALNWLESSYCNGRLALVVAADIAVYGEKSARPTGGAGAVAILLGPNAPLVIDPGL 189
>UniRef50_UPI00005A343B Cluster: PREDICTED: similar to
Hydroxymethylglutaryl-CoA synthase, mitochondrial
precursor (HMG-CoA synthase) (3-hydroxy-3-methylglutaryl
coenzyme A synthase); n=1; Canis lupus familiaris|Rep:
PREDICTED: similar to Hydroxymethylglutaryl-CoA
synthase, mitochondrial precursor (HMG-CoA synthase)
(3-hydroxy-3-methylglutaryl coenzyme A synthase) - Canis
familiaris
Length = 417
Score = 214 bits (523), Expect = 2e-54
Identities = 104/188 (55%), Positives = 134/188 (71%), Gaps = 4/188 (2%)
Frame = +3
Query: 102 TVNMGGKVENVGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDIN 281
+V++G + GILA+E+YFP+ Y+DQT+LE ++ V G Y +G GQ+ MGFCS +ED+N
Sbjct: 14 SVSLGYLAKGYGILALEVYFPTHYMDQTDLENYNNVEAGSYAVGFGQTHMGFCSVQEDLN 73
Query: 282 SICLTALHRLIDKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTT 461
S+CLT + +L++ + + +G LEVGTE +IDKSK+VKT LM LF G TDIEGI TT
Sbjct: 74 SLCLTVVQQLMECMQFPWNSVGWLEVGTEMVIDKSKAVKTVLMELFQDSGNTDIEGIGTT 133
Query: 462 NACYGGTAALFNAINWVESSSWDGRKAIVVA---GDIAVYGKGP-ARPTGGAGAVAMLIG 629
NACYGGTA+LFNA NWVESSSWDG A+ A I V G A PTGGA AV +L+G
Sbjct: 134 NACYGGTASLFNAANWVESSSWDGGYAVWSAETLQSIPVIVTGDNAHPTGGARAVTVLVG 193
Query: 630 PDAPLVFD 653
P APL +
Sbjct: 194 PMAPLTLE 201
>UniRef50_Q8SR61 Cluster: 3-HYDROXY-3-METHYLGLUTARYL-CoA SYNTHASE 2;
n=1; Encephalitozoon cuniculi|Rep:
3-HYDROXY-3-METHYLGLUTARYL-CoA SYNTHASE 2 -
Encephalitozoon cuniculi
Length = 382
Score = 184 bits (448), Expect = 2e-45
Identities = 101/219 (46%), Positives = 129/219 (58%)
Frame = +3
Query: 135 GILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTALHRLI 314
GI+ +E PS Y+ Q E+ + K IGLG +MG S RED S+ L A+ RL+
Sbjct: 8 GIIGVEYQLPSLYISQEEVANNIDFEVDKIKIGLGLEQMGVPSRREDAISLALNAVSRLM 67
Query: 315 DKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGGTAALF 494
+ ++ IGRLEVGTE+ D SKS+K++L LF G T I G D +ACY GT AL
Sbjct: 68 KRYNVDPMAIGRLEVGTESNPDGSKSIKSYLTDLFP--GNTSICGCDNVHACYSGTNALL 125
Query: 495 NAINWVESSSWDGRKAIVVAGDIAVYGKGPARPTGGAGAVAMLIGPDAPLVFDCGVRASY 674
+AI W+ESS WDGR AIVVA D+A+Y +PTGGAGAVA+L+GP+ Y
Sbjct: 126 SAIAWMESSFWDGRLAIVVASDVAMYKDKSCQPTGGAGAVAILLGPNCIYRVVPSSVIHY 185
Query: 675 MTHAYDFYKPDLSSEFPYVXGKLSIQCYLNALXNCYNLF 791
T+ +DF KP FP V GK SI+ Y A CY F
Sbjct: 186 FTNQFDFMKPRELHPFPVVKGKESIENYRTAFEICYGRF 224
>UniRef50_Q7QQE4 Cluster: GLP_91_15470_16939; n=1; Giardia lamblia
ATCC 50803|Rep: GLP_91_15470_16939 - Giardia lamblia
ATCC 50803
Length = 489
Score = 148 bits (359), Expect = 1e-34
Identities = 91/222 (40%), Positives = 121/222 (54%), Gaps = 10/222 (4%)
Frame = +3
Query: 132 VGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTALHRL 311
V I A+ +Y P V Q E+ ++ K T GLGQ +M D ED S+ L +L L
Sbjct: 18 VRIAAIAVYIPPIVVSQEEVSSLCKIPLEKITKGLGQHQMAVTVDSEDSVSLALNSLQLL 77
Query: 312 IDKQK----INLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGG 479
ID + ++ IGRLEVGTE+ +DK+KS+K+ L + GA G D NAC GG
Sbjct: 78 IDDKATQDILSKVTIGRLEVGTESSVDKAKSIKSVLADML---GAVRTTGADIINACLGG 134
Query: 480 TAALFNAINWVESSSWDGR-----KAIVVAGDIAVYGKGPARPTGGAGAVAMLIGPDAPL 644
AL NA W+ ++ +D AIVV DI++Y + PTGGAGAVA+L+ D P
Sbjct: 135 VLALENAALWLSAAKYDDETNKYPAAIVVTTDISIYNDIASIPTGGAGAVALLLVKDYPS 194
Query: 645 VFDCGVR-ASYMTHAYDFYKPDLSSEFPYVXGKLSIQCYLNA 767
C SY + DFYKP ++S P V G SI+CYL A
Sbjct: 195 GIVCDASFNSYWENTTDFYKPHIASPVPVVHGATSIECYLRA 236
>UniRef50_Q1D4I1 Cluster: Hydroxymethylglutaryl-CoA synthase; n=2;
Cystobacterineae|Rep: Hydroxymethylglutaryl-CoA synthase
- Myxococcus xanthus (strain DK 1622)
Length = 418
Score = 145 bits (352), Expect = 1e-33
Identities = 92/222 (41%), Positives = 119/222 (53%), Gaps = 3/222 (1%)
Frame = +3
Query: 126 ENVGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTALH 305
+ VGI A+ + PS+YVD +L + V KYT GLG +M ED ++ TA
Sbjct: 3 KRVGIEALAVAVPSRYVDIEDLARARGVDPAKYTAGLGAREMAVTDPGEDTVALAATAAA 62
Query: 306 RLIDKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGGTA 485
RLI +Q ++ IG L VGTET ID SK V + + L K T + DT +ACYGGTA
Sbjct: 63 RLIRQQDVDPSRIGMLVVGTETGIDHSKPVASHVQGLL-KLPRT-MRTYDTQHACYGGTA 120
Query: 486 ALFNAINWVESSSWDGRKAIVVAGDIAVYGKGPA-RPTGGAGAVAMLIG--PDAPLVFDC 656
L A+ W+ S + G+ A+VV DIA YG A PT G GAVA+L+ PD L D
Sbjct: 121 GLMAAVEWIASGAGAGKVAVVVCSDIARYGLNTAGEPTQGGGAVALLVSEQPDL-LAMDV 179
Query: 657 GVRASYMTHAYDFYKPDLSSEFPYVXGKLSIQCYLNALXNCY 782
G+ YDF++P + V G SI CYL AL Y
Sbjct: 180 GLNGVCSMDVYDFWRP-VGRREALVDGHYSITCYLEALSGAY 220
>UniRef50_A0RW92 Cluster: 3-hydroxy-3-methylglutaryl CoA synthase;
n=2; Thermoprotei|Rep: 3-hydroxy-3-methylglutaryl CoA
synthase - Cenarchaeum symbiosum
Length = 464
Score = 122 bits (294), Expect = 1e-26
Identities = 75/226 (33%), Positives = 119/226 (52%), Gaps = 7/226 (3%)
Frame = +3
Query: 135 GILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTALHRLI 314
GI + +Y P Y+D + V K GLG ++M +D + A R++
Sbjct: 4 GIDDISVYIPKLYLDAGDYALMRGVDATKLRDGLGVNQMAMVDSNQDPACLAANACLRIM 63
Query: 315 DKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAK---EGATD-IEGIDTTNACYGGT 482
K++ DIGRL V TE+ D+SK++ ++++ + + +G+ + G++T AC G+
Sbjct: 64 QSNKLSPDDIGRLYVSTESSFDESKAMNSYVIGMLEQVYGQGSFEHCGGVETKFACVSGS 123
Query: 483 AALFNAINWVESSSWDGRKAIVVAGDIAVYGKGPA-RPTGGAGAVAMLIGPDAP--LVFD 653
AL++ NW+ + +G A+VV DIA Y KG + T GAGA+AML+ D P L FD
Sbjct: 124 YALYDNANWIRAGEAEGMNALVVVSDIAKYDKGSSGEMTQGAGAIAMLLN-DEPRLLAFD 182
Query: 654 CGVRASYMTHAYDFYKPDLSSEFPYVXGKLSIQCYLNALXNCYNLF 791
V A+ + YDFY+P E P V G+ S YL + N ++
Sbjct: 183 PKVTATSIKDEYDFYRP-FGKETPIVHGQYSNLLYLIQVRNALEIY 227
>UniRef50_Q5V1G0 Cluster: Hydroxymethylglutaryl-CoA synthase; n=5;
Halobacteriaceae|Rep: Hydroxymethylglutaryl-CoA synthase
- Haloarcula marismortui (Halobacterium marismortui)
Length = 445
Score = 114 bits (274), Expect = 3e-24
Identities = 78/216 (36%), Positives = 108/216 (50%), Gaps = 6/216 (2%)
Frame = +3
Query: 132 VGILAMELYFPSQYVDQTE-LEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTALHR 308
VGI AME++ +D E GKYT GLG F EDI ++ A HR
Sbjct: 4 VGIDAMEIWTGKLKLDLAETFAPAQGDDPGKYTKGLGLRASSFPDVYEDIVTMGANAAHR 63
Query: 309 LIDKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAK---EGATDIEGIDTTNACYGG 479
L++++ + DIGR++V TE+ D SK V T++ + E + AC G
Sbjct: 64 LMERKGLTPEDIGRIDVATESAFDNSKPVSTYIAGCLEQVYDENFHHANKGERKFACISG 123
Query: 480 TAALFNAINWVESSSWDGRKAIVVAGDIAVYGK-GPARPTGGAGAVAMLIGPDAPLVFDC 656
T +L +A NW+ + GR A+V+A D A+Y + P T GAGAVAML+ D LV +
Sbjct: 124 TQSLDDAYNWIRAGRNRGRAALVIATDTALYARDDPGEATQGAGAVAMLVDEDPNLV-EL 182
Query: 657 GVRASY-MTHAYDFYKPDLSSEFPYVXGKLSIQCYL 761
Y DF KP + +FP V GK S+ YL
Sbjct: 183 STEQGYGSADETDFLKP--NQQFPSVDGKRSVNVYL 216
>UniRef50_Q9FD82 Cluster: HMG-CoA synthase; n=16;
Staphylococcus|Rep: HMG-CoA synthase - Staphylococcus
haemolyticus
Length = 388
Score = 98.7 bits (235), Expect = 1e-19
Identities = 66/220 (30%), Positives = 105/220 (47%), Gaps = 1/220 (0%)
Frame = +3
Query: 129 NVGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTALHR 308
++GI + Y P YVD +L + +V K+ IG+GQ++M +DI S+ A
Sbjct: 2 SIGIDKINFYVPKYYVDMAKLAEARQVDPNKFLIGIGQTQMAVSPVSQDIVSMGANAAKD 61
Query: 309 LIDKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGGTAA 488
+I + IG + V TE+ ID +K+ + L + + ACY T A
Sbjct: 62 IITDD--DKKHIGMVIVATESAIDNAKAAAVQIHNLLGVQPFA--RCFEMKEACYAATPA 117
Query: 489 LFNAINWVESSSWDGRKAIVVAGDIAVYG-KGPARPTGGAGAVAMLIGPDAPLVFDCGVR 665
+ A +++E K +V+A D A YG + PT GAGAVAMLI + ++
Sbjct: 118 IQLAKDYIEKR--PNEKVLVIASDTARYGIQSGGEPTQGAGAVAMLISNNPSILELNDDA 175
Query: 666 ASYMTHAYDFYKPDLSSEFPYVXGKLSIQCYLNALXNCYN 785
+Y YDF++P ++P V G LS Y+ + +N
Sbjct: 176 VAYTEDVYDFWRP-TGHKYPLVAGALSKDAYIKSFQESWN 214
>UniRef50_A5EUV4 Cluster: Hydroxymethylglutaryl-CoA synthase; n=1;
Dichelobacter nodosus VCS1703A|Rep:
Hydroxymethylglutaryl-CoA synthase - Dichelobacter
nodosus (strain VCS1703A)
Length = 384
Score = 97.5 bits (232), Expect = 3e-19
Identities = 71/219 (32%), Positives = 102/219 (46%), Gaps = 1/219 (0%)
Frame = +3
Query: 132 VGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTALHRL 311
VGI + Y P Y++ + L + D V KY GLGQ + EDI ++ A L
Sbjct: 4 VGIDKIGFYIPKYYMELSTLAQRDGVEAKKYHEGLGQMRFAVAPHDEDIVTLASNAAFAL 63
Query: 312 IDKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGGTAAL 491
ID+ + I + V TET ID+SKS ++ L + ++ ACY TA L
Sbjct: 64 IDED--DRQAIDSVIVATETGIDQSKSAAVYVHRLL--NLSPRCRAVELKQACYSTTAGL 119
Query: 492 FNAINWVESSSWDGRKAIVVAGDIAVYG-KGPARPTGGAGAVAMLIGPDAPLVFDCGVRA 668
A ++V ++ RK +++A DIA Y A T G AVAM+I + G+
Sbjct: 120 QFACSYV--AAHPNRKVLLIASDIARYDLHSAAEVTQGCAAVAMVIAAHPRIAVWHGLSG 177
Query: 669 SYMTHAYDFYKPDLSSEFPYVXGKLSIQCYLNALXNCYN 785
Y DF++P+ P V GK S YL A N +N
Sbjct: 178 IYTEEVMDFWRPN-HRHTPLVDGKFSTTVYLRAAQNAFN 215
>UniRef50_A0NJ77 Cluster: 3-hydroxy-3-methylglutaryl CoA synthase;
n=3; Leuconostocaceae|Rep: 3-hydroxy-3-methylglutaryl
CoA synthase - Oenococcus oeni ATCC BAA-1163
Length = 389
Score = 96.7 bits (230), Expect = 6e-19
Identities = 68/211 (32%), Positives = 102/211 (48%), Gaps = 2/211 (0%)
Frame = +3
Query: 132 VGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTALHRL 311
+GI + + P+ Y+D TEL + V KY +G+GQ K +D S+ A L
Sbjct: 3 IGIDQISFFTPNLYLDLTELAEKRGVDPNKYLVGIGQEKQSIVPPTQDSVSMAANAASIL 62
Query: 312 IDKQKIN-LHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGGTAA 488
++++ L+ I + +E+ ID SKS +L L + ++ I+ ACYGGT A
Sbjct: 63 LEQKSTEFLNSIDEILFASESGIDNSKSGAVYLQKLLNLK--KNMRAIEIKQACYGGTFA 120
Query: 489 LFNAINWVESSSWDGRKAIVVAGDIAVYG-KGPARPTGGAGAVAMLIGPDAPLVFDCGVR 665
L A ++V+ ++ +VVA DIA YG K T GAGAVAML+ L
Sbjct: 121 LMTAFDYVKLH--PNKRILVVASDIARYGLKSAGEVTQGAGAVAMLVSTQPRLASYNWDS 178
Query: 666 ASYMTHAYDFYKPDLSSEFPYVXGKLSIQCY 758
DF++P L V GK+S + Y
Sbjct: 179 VFQSEDLMDFWRP-LDQSEALVFGKMSQEIY 208
>UniRef50_Q88VI4 Cluster: Hydroxymethylglutaryl-CoA synthase; n=44;
Bacilli|Rep: Hydroxymethylglutaryl-CoA synthase -
Lactobacillus plantarum
Length = 389
Score = 93.5 bits (222), Expect = 5e-18
Identities = 71/213 (33%), Positives = 101/213 (47%), Gaps = 2/213 (0%)
Frame = +3
Query: 132 VGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTALHRL 311
VGI + YVD EL + KY IG+GQSKM +D ++ A +
Sbjct: 3 VGIDKLHFATSHLYVDMAELATARQAEPDKYLIGIGQSKMAVIPPSQDAVTLAANAAAPM 62
Query: 312 IDKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGGTAAL 491
+ I D+ L VGTE+ ID SK+ ++ L + + I+ ACY TA +
Sbjct: 63 LTATDIAAIDL--LVVGTESGIDNSKASAIYVAKLLGL--SQRVRTIEMKEACYAATAGV 118
Query: 492 FNAINWVESSSWDGRKAIVVAGDIAVYG-KGPARPTGGAGAVAMLIGPDAPLVFDCGVRA 668
A + V +KA+V+ D+A YG P PT G GAVAMLI D P V G +
Sbjct: 119 QLAQDHVRVH--PDKKALVIGSDVARYGLNTPGEPTQGGGAVAMLISAD-PKVLALGTES 175
Query: 669 SYMTH-AYDFYKPDLSSEFPYVXGKLSIQCYLN 764
S ++ DF++P +E V GK S Y++
Sbjct: 176 SLLSEDVMDFWRPLYHTE-ALVDGKYSSNIYID 207
>UniRef50_A5FM54 Cluster: Hydroxymethylglutaryl-CoA synthase; n=2;
Flavobacteriales|Rep: Hydroxymethylglutaryl-CoA synthase
- Flavobacterium johnsoniae UW101
Length = 453
Score = 91.5 bits (217), Expect = 2e-17
Identities = 60/163 (36%), Positives = 88/163 (53%), Gaps = 5/163 (3%)
Frame = +3
Query: 231 GLGQSKMGFCSDREDINSICLTALHRLIDKQKINLHDIGRLEVGTETIIDKSKSVKTFLM 410
GLG KM F +D AL +LI KI+L +I R+ VGTE+ ID SK + ++L+
Sbjct: 36 GLGLLKMTFPDVHQDAVVFGANALTKLIIDNKIDLKEISRIYVGTESSIDSSKPIASYLI 95
Query: 411 TL----FAKEGATDIEGIDTTNACYGGTAALFNAINWVESSSWDGRKAIVVAGDIAVYG- 575
+L F ++ + + +D T AC GG A+ N +++V+ + +KAIVV D A Y
Sbjct: 96 SLMEQKFGEDSLAECDVVDFTFACIGGVDAMQNCLDFVKLN--PAKKAIVVTSDFAKYDL 153
Query: 576 KGPARPTGGAGAVAMLIGPDAPLVFDCGVRASYMTHAYDFYKP 704
T GAGAVAMLI D ++ A+ +DF+KP
Sbjct: 154 NSGGEYTQGAGAVAMLITADPKIIAFDDNWATSTKGVFDFFKP 196
>UniRef50_Q8L1I3 Cluster: HMG-CoA synthase; n=1; Paracoccus
zeaxanthinifaciens|Rep: HMG-CoA synthase - Paracoccus
zeaxanthinifaciens
Length = 388
Score = 89.0 bits (211), Expect = 1e-16
Identities = 70/224 (31%), Positives = 104/224 (46%), Gaps = 2/224 (0%)
Frame = +3
Query: 120 KVENVGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTA 299
K+ GI A+ Y P YV L + K++ G+GQ K+ EDI ++ A
Sbjct: 5 KMTVTGIEAISFYTPQNYVGLDILAAHHGIDPEKFSKGIGQEKIALPGHDEDIVTMAAEA 64
Query: 300 LHRLIDKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGG 479
+I ++ I + TE+ ID+SK+ +L L + + + ++ ACY
Sbjct: 65 ALPII--ERAGTQGIDTVLFATESGIDQSKAAAIYLRRLL--DLSPNCRCVELKQACYSA 120
Query: 480 TAALFNAINWVESSSWDGRKAIVVAGDIAVYGK-GPARPTGGAGAVAMLIGPDAPLVFDC 656
TAAL A V RK +V+A D+A Y + T GAGAVA+L+ D P V +
Sbjct: 121 TAALQMACAHVARK--PDRKVLVIASDVARYDRESSGEATQGAGAVAILVSAD-PKVAEI 177
Query: 657 GVRASYMTH-AYDFYKPDLSSEFPYVXGKLSIQCYLNALXNCYN 785
G + T DF++P+ P GK S YLNAL +N
Sbjct: 178 GTVSGLFTEDIMDFWRPN-HRRTPLFDGKASTLRYLNALVEAWN 220
>UniRef50_Q9FD56 Cluster: HMG-CoA synthase; n=46;
Streptococcaceae|Rep: HMG-CoA synthase - Streptococcus
pneumoniae
Length = 398
Score = 83.8 bits (198), Expect = 4e-15
Identities = 66/204 (32%), Positives = 104/204 (50%), Gaps = 2/204 (0%)
Frame = +3
Query: 165 SQYVDQTE-LEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTALHRLIDKQKINLHD 341
SQYV + + L + + K + GL ++ EDI ++ +A ++ +Q+ +
Sbjct: 21 SQYVLKLQDLAEARGIDPEKLSKGLLLKELSIAPLTEDIVTLAASASDSILTEQE--RQE 78
Query: 342 IGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGGTAALFNAINWVESS 521
+ + V TE+ ID+SK+ F+ L + + ACYG TAAL A VE+S
Sbjct: 79 VDMVIVATESGIDQSKAAAVFVHGLLGIQPFA--RSFEIKEACYGATAALHYAKLHVENS 136
Query: 522 SWDGRKAIVVAGDIAVYG-KGPARPTGGAGAVAMLIGPDAPLVFDCGVRASYMTHAYDFY 698
K +V+A DIA YG + P PT GAG+VAMLI + ++ + DF+
Sbjct: 137 PES--KVLVIASDIAKYGIETPGEPTQGAGSVAMLITQNPRMMAFNNDNVAQTRDIMDFW 194
Query: 699 KPDLSSEFPYVXGKLSIQCYLNAL 770
+P+ S+ PYV G S Q YL++L
Sbjct: 195 RPNYSTT-PYVNGVYSTQQYLDSL 217
>UniRef50_Q04AW0 Cluster: 3-hydroxy-3-methylglutaryl CoA synthase;
n=4; Lactobacillus delbrueckii|Rep:
3-hydroxy-3-methylglutaryl CoA synthase - Lactobacillus
delbrueckii subsp. bulgaricus (strain ATCC BAA-365)
Length = 387
Score = 83.4 bits (197), Expect = 6e-15
Identities = 62/222 (27%), Positives = 106/222 (47%), Gaps = 1/222 (0%)
Frame = +3
Query: 129 NVGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTALHR 308
++GI + Y P+++VD +L K+ IG+GQ +M +D S+ + A
Sbjct: 2 DIGIDQIGFYTPNKFVDMVDLANARNQDPNKFLIGIGQDRMAVADKTQDAVSMGINATAE 61
Query: 309 LIDKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGGTAA 488
+D +++L +G L TE+ ID+SKS F+ A I + AC+ TA+
Sbjct: 62 YLD--QVDLEQLGLLIFATESGIDQSKSASLFVKE--ALNLPARIRTFEIKEACFALTAS 117
Query: 489 LFNAINWVESSSWDGRKAIVVAGDIAVYGKGPA-RPTGGAGAVAMLIGPDAPLVFDCGVR 665
L A ++V + A+++ DIA YG A T GAGA++MLI + ++
Sbjct: 118 LQVARDYVRAH--PHHSAMIIGSDIARYGLATAGEVTQGAGAISMLIKENPAIIALEDGH 175
Query: 666 ASYMTHAYDFYKPDLSSEFPYVXGKLSIQCYLNALXNCYNLF 791
S+ + DF++P+ + V G S YL+ + + F
Sbjct: 176 TSHSENINDFWRPN-NLATAVVDGHYSRDVYLDFFKSTFKPF 216
>UniRef50_A4FIG4 Cluster: Hydroxymethylglutaryl-CoA synthase; n=1;
Saccharopolyspora erythraea NRRL 2338|Rep:
Hydroxymethylglutaryl-CoA synthase - Saccharopolyspora
erythraea (strain NRRL 23338)
Length = 407
Score = 77.8 bits (183), Expect = 3e-13
Identities = 64/219 (29%), Positives = 102/219 (46%), Gaps = 2/219 (0%)
Frame = +3
Query: 132 VGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTALHRL 311
VGI A+ Y S Y++ +L + G+ LG + + ED+ ++ TA L
Sbjct: 5 VGIEAVGAYCGSAYLETEDLFAARGLDAGRIG-NLGLRRKSVAAPGEDVVAMAATAARPL 63
Query: 312 IDKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGGTAAL 491
+D + I L V TE+ +D SK+ T + L + ++ AC+GG AAL
Sbjct: 64 VDAVD-DKASIRTLVVATESPLDLSKAASTHVHQLLGLPRQCRL--LEVKQACHGGAAAL 120
Query: 492 FNAINWVESSSWDGRKAIVVAGDIAVYGKGP-ARPTGGAGAVAMLIGPDAPLV-FDCGVR 665
A + V + G +A+V+A D V +G P GAGAVA+L+GP +V + G
Sbjct: 121 GLAASVVATEP--GSRALVIASDTPVPTRGSYMEPAQGAGAVAVLVGPQPRVVELELGTT 178
Query: 666 ASYMTHAYDFYKPDLSSEFPYVXGKLSIQCYLNALXNCY 782
Y DF++P + + LS+ YL+ L +
Sbjct: 179 GCYGYETPDFFRP--RPDVDVMDTDLSLMSYLDCLIGAF 215
>UniRef50_A7QFV6 Cluster: Chromosome undetermined scaffold_89, whole
genome shotgun sequence; n=2; Magnoliophyta|Rep:
Chromosome undetermined scaffold_89, whole genome
shotgun sequence - Vitis vinifera (Grape)
Length = 117
Score = 73.7 bits (173), Expect = 5e-12
Identities = 45/101 (44%), Positives = 60/101 (59%), Gaps = 3/101 (2%)
Frame = +3
Query: 126 ENVGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKM---GFCSDREDINSICLT 296
+NVGILAM++YFP V Q TG L S + FCS+ ED+ S+ T
Sbjct: 3 KNVGILAMDIYFPPSCVQQV---------TGLSLCFLFLSLIFLPAFCSEVEDVISMSST 53
Query: 297 ALHRLIDKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLF 419
+ L++K I+ I +LEVG ET+IDKSKS+KTFLM +F
Sbjct: 54 VVTSLLEKYGIDTKQISQLEVGNETVIDKSKSIKTFLMQIF 94
>UniRef50_Q767G7 Cluster: HMG-CoA synthase; n=9; Bacteria|Rep:
HMG-CoA synthase - Actinoplanes sp. A40644
Length = 391
Score = 71.7 bits (168), Expect = 2e-11
Identities = 57/207 (27%), Positives = 95/207 (45%), Gaps = 2/207 (0%)
Frame = +3
Query: 168 QYVDQTE-LEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTALHRLIDKQKINLHDI 344
QYV E L + KY G+GQ M + EDI ++ A ++ + + I
Sbjct: 18 QYVLTHETLAAENGADVAKYHKGIGQRSMSVPAVDEDIVTMAAAAAAPVVARHGAD--QI 75
Query: 345 GRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGGTAALFNAINWVESSS 524
+ TE+ ID++K+ ++ +L + ++ ACY GTAAL A+ V
Sbjct: 76 RTVLFATESSIDQAKAAGIYVHSLLGLPAGARV--VELKQACYSGTAALQFALGLVHRDR 133
Query: 525 WDGRKAIVVAGDIAVYGKG-PARPTGGAGAVAMLIGPDAPLVFDCGVRASYMTHAYDFYK 701
+ +V+A D++ Y +G P T GA AVAML+ + L+ + DF++
Sbjct: 134 --SEQVLVIASDVSKYERGTPGEATQGAAAVAMLVSAEPALMRIENPSGMFTADIMDFWR 191
Query: 702 PDLSSEFPYVXGKLSIQCYLNALXNCY 782
P+ + V G+ SI YL A+ +
Sbjct: 192 PNYRTT-ALVDGQESISAYLQAVEGAW 217
>UniRef50_P40830 Cluster: Putative polyketide biosynthesis protein
pksG; n=31; Bacteria|Rep: Putative polyketide
biosynthesis protein pksG - Bacillus subtilis
Length = 420
Score = 66.1 bits (154), Expect = 1e-09
Identities = 67/226 (29%), Positives = 103/226 (45%), Gaps = 14/226 (6%)
Frame = +3
Query: 129 NVGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTALHR 308
+ GI AM ++ + Y+D EL K+ + T ++ L + K ED + + A
Sbjct: 3 SAGIEAMNVFGGTAYLDVMELAKYRHLDTARFENLLMKEK-AVALPYEDPVTFGVNAAKP 61
Query: 309 LIDKQKINLHD-IGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGGTA 485
+ID D I L +E+ ID KS+ T++ + + ACY GTA
Sbjct: 62 IIDALSEAEKDRIELLITCSESGIDFGKSLSTYIHEYLGLNRNCRL--FEVKQACYSGTA 119
Query: 486 ALFNAINWVESSSWDGRKAIVVAGDIA--VYGKGP---------ARPTGGAGAVAMLIGP 632
A+N++ S + G KA+V+A DI+ + +G A P+ GAGAVA+L+G
Sbjct: 120 GFQMAVNFILSQTSPGAKALVIASDISRFLIAEGGDALSEDWSYAEPSAGAGAVAVLVG- 178
Query: 633 DAPLVF--DCGVRASYMTHAYDFYKPDLSSEFPYVXGKLSIQCYLN 764
+ P VF D G Y D +P SE LS+ YL+
Sbjct: 179 ENPEVFQIDPGANGYYGYEVMDTCRPIPDSEAG--DSDLSLMSYLD 222
>UniRef50_A6G789 Cluster: Hydroxymethylglutaryl-CoA synthase; n=1;
Plesiocystis pacifica SIR-1|Rep:
Hydroxymethylglutaryl-CoA synthase - Plesiocystis
pacifica SIR-1
Length = 510
Score = 64.1 bits (149), Expect = 4e-09
Identities = 68/235 (28%), Positives = 103/235 (43%), Gaps = 25/235 (10%)
Frame = +3
Query: 135 GILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTALHRLI 314
GI A+ +Y P VD ++ K +G+S C+ E++ ++ A +LI
Sbjct: 15 GISAISIYLPRNRVDLERWCEWTGAPWAKVAAVVGRS-FRVCAPDENVYTMAANAALQLI 73
Query: 315 DKQKINLHDIGRLEVGTETIIDKSKS---VKTFLMTLFAKEG----ATDIEGIDTTNACY 473
+ I+ +G +GTE+ D + V+ + G A D E + +AC
Sbjct: 74 EANGIDPRRVGYFALGTESSTDNAAGAVIVRGMVDEALRVRGLPSLARDCEVPEFKHACL 133
Query: 474 GGTAALFNAINWVESSSWDGRKAIVVAGDIAVYGKGPA-RPTGGAGAVAMLIGPDAPLV- 647
GG A+ +A ++ + R AIVV+ DIA Y +G T GAGAVA + + L+
Sbjct: 134 GGVYAMKSAARYLACEGRE-RVAIVVSSDIAAYRRGSTGEQTQGAGAVAFAMEAEPKLLA 192
Query: 648 FD---CGVRASYMTHAYDFYKP-------DLSSE------FPYVXGKLSIQCYLN 764
D G +SY YDF KP D E FP GK S CY++
Sbjct: 193 LDLDRAGSASSY--RGYDFRKPFARHFMADYRGEEQTPRDFPVFNGKYSTLCYVD 245
>UniRef50_A6G7N7 Cluster: Hydroxymethylglutaryl-coenzyme A synthase;
n=1; Plesiocystis pacifica SIR-1|Rep:
Hydroxymethylglutaryl-coenzyme A synthase - Plesiocystis
pacifica SIR-1
Length = 420
Score = 63.7 bits (148), Expect = 5e-09
Identities = 44/135 (32%), Positives = 65/135 (48%), Gaps = 3/135 (2%)
Frame = +3
Query: 324 KINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGGTAALFNAI 503
+I+ + + VGTE+ +D K + +++ L + + +T +ACYGGT L A
Sbjct: 78 EIDPKQVEMIVVGTESSVDFGKPISSWVQRLSG--ASANCRNFETKHACYGGTGGLMAAA 135
Query: 504 NWVESSSWDGRKAIVVAGDIAVYGKG-PARPTGGAGAVAMLIGPDAP--LVFDCGVRASY 674
+WV S G+KA+VV D + G P GAGA AMLI D P L F+ +
Sbjct: 136 HWVASGFNRGKKALVVCADQSRMHLGKPWEFVLGAGATAMLIS-DQPDFLEFELDKNGYW 194
Query: 675 MTHAYDFYKPDLSSE 719
D Y+P E
Sbjct: 195 TNEISDTYRPTSRDE 209
>UniRef50_Q4QAB9 Cluster: Putative uncharacterized protein; n=5;
Trypanosomatidae|Rep: Putative uncharacterized protein -
Leishmania major
Length = 501
Score = 61.7 bits (143), Expect = 2e-08
Identities = 62/199 (31%), Positives = 90/199 (45%), Gaps = 8/199 (4%)
Frame = +3
Query: 135 GILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTALHRLI 314
G+ M +Y P VD + K+ S K + +GQS S E+ ++ A+ RLI
Sbjct: 11 GVSGMAVYAPHCRVDLEQWCKWTGNSWDKVSSVVGQS-FRITSHNENAYTMAANAVLRLI 69
Query: 315 DKQKINLHDIGRLEVGTETIIDKSKS-------VKTFLMTLFAKEGATDIEGIDTTNACY 473
I+ IG L +GTE+ D S V L + + E + +AC
Sbjct: 70 VNNNIDPTKIGFLGLGTESSSDNSAGAIIVKGMVDKGLRAMNMPAMSRHCEVPEFKHACL 129
Query: 474 GGTAALFNAINWVESSSWDGRKAIVVAGDIAVYGKG-PARPTGGAGAVAMLIGPDAPLVF 650
G A+ +A +V + D R AI VA DIA Y G T GAGA AM++ D P +F
Sbjct: 130 AGVYAMESATRFVNADGKD-RMAIAVASDIAEYALGSTGEQTQGAGATAMVLEHD-PKLF 187
Query: 651 DCGVRASYMTHAYDFYKPD 707
+ V+ + A D+ PD
Sbjct: 188 E--VQLQHSGSASDYRGPD 204
>UniRef50_UPI000038D51C Cluster: COG3425: 3-hydroxy-3-methylglutaryl
CoA synthase; n=1; Nostoc punctiforme PCC 73102|Rep:
COG3425: 3-hydroxy-3-methylglutaryl CoA synthase -
Nostoc punctiforme PCC 73102
Length = 408
Score = 58.8 bits (136), Expect = 1e-07
Identities = 59/223 (26%), Positives = 94/223 (42%), Gaps = 3/223 (1%)
Frame = +3
Query: 123 VENVGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTAL 302
++ VGI + LY D EL + + ED ++ + A
Sbjct: 1 MQRVGIEKINLYAGRFCADALELANLQGKDLDYVSKQVKVKTRSVIPAYEDTVTLSVNAA 60
Query: 303 HRLIDKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGGT 482
RL+ + + DI L V TE+ +D K V T++ + +ACYG T
Sbjct: 61 KRLLSPE--DARDIELLIVATESAVDFGKPVSTWVHRYCNLP--PHCRSFELKHACYGLT 116
Query: 483 AALFNAINWVESSSWDGRKAIVVAGDIA-VYGKGPARPTGGAGAVAMLIGPDAPLVFDCG 659
AA+ A W++ G+KA+V+ D + + GG A+AMLI D P VF+
Sbjct: 117 AAVKTAAMWLQGGLTPGKKALVIGCDYSRPHLDDRDNFIGGGAAIAMLISTD-PKVFEID 175
Query: 660 VR-ASYMTHAY-DFYKPDLSSEFPYVXGKLSIQCYLNALXNCY 782
+ A + T+ D ++P E + S+ YL+AL Y
Sbjct: 176 LHPAGFWTNEISDTFRPTARVEIG--DNQTSLYSYLDALEASY 216
>UniRef50_Q7LZE7 Cluster: Hydroxymethylglutaryl-CoA synthase; n=2;
Eukaryota|Rep: Hydroxymethylglutaryl-CoA synthase -
Gallus gallus (Chicken)
Length = 42
Score = 57.2 bits (132), Expect = 4e-07
Identities = 23/33 (69%), Positives = 27/33 (81%)
Frame = +3
Query: 663 RASYMTHAYDFYKPDLSSEFPYVXGKLSIQCYL 761
+ ++M HAYDFYKPDLS E+P V G LSIQCYL
Sbjct: 10 KGTHMEHAYDFYKPDLSXEYPVVDGXLSIQCYL 42
>UniRef50_Q1CGN1 Cluster: Hydroxymethylglutaryl-coenzyme A synthase;
n=8; Yersinia|Rep: Hydroxymethylglutaryl-coenzyme A
synthase - Yersinia pestis (biovar Antiqua strain
Nepal516)
Length = 412
Score = 52.8 bits (121), Expect = 9e-06
Identities = 51/224 (22%), Positives = 99/224 (44%), Gaps = 4/224 (1%)
Frame = +3
Query: 123 VENVGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTAL 302
+ ++GI + +Y S + +EL + L K ED ++ + +
Sbjct: 1 MNSIGIEKISIYPSSLALKLSELAQARGGDNKYIQESLMVIKRSLVPQWEDAVTLAVNSA 60
Query: 303 HRLIDKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGGT 482
+++ Q + DIG + TE+ +D+ K++ T+ + + +AC+ G
Sbjct: 61 KDMLNDQ--DRSDIGLFIIATESGLDQEKAISTWAHRYLGLPATCRV--FELKSACHAGA 116
Query: 483 AALFNAINWVESSSWDGRKAIVVAGDIA--VYGKGPARPTGGAGAVAMLIGPDAPL--VF 650
AAL A +W+ S G+K +++ DI+ + G + GAGA+A+LI D P+ V
Sbjct: 117 AALKMAESWISSGLNRGKKVLLINVDISNNMICHGKMEYSLGAGAIALLIS-DNPVFAVI 175
Query: 651 DCGVRASYMTHAYDFYKPDLSSEFPYVXGKLSIQCYLNALXNCY 782
+ G + D +P E + + S+ Y++ L N +
Sbjct: 176 ETGKSGIHTHEVTDVIRPLPWKEVAF-DVEASLFSYMDGLENAF 218
>UniRef50_Q6MLJ5 Cluster: 3-oxoacyl-(Acyl-carrier-protein) synthase
III; n=1; Bdellovibrio bacteriovorus|Rep:
3-oxoacyl-(Acyl-carrier-protein) synthase III -
Bdellovibrio bacteriovorus
Length = 331
Score = 44.0 bits (99), Expect = 0.004
Identities = 28/107 (26%), Positives = 47/107 (43%)
Frame = +3
Query: 156 YFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTALHRLIDKQKINL 335
Y P + + +LEK E + G + S+ + + +C+ A R ++ + +
Sbjct: 15 YLPEKILSNKDLEKMVETNDQWIVERTGIERRHIASEDQATSDLCVIAAKRALEDANLKV 74
Query: 336 HDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYG 476
DI + VGT T + S F+ AK GA +I +D AC G
Sbjct: 75 EDIDMILVGTVTGDHQMPSTACFVQ---AKLGAKNIMAVDLNAACSG 118
>UniRef50_P51196 Cluster: 3-oxoacyl-[acyl-carrier-protein] synthase
3; n=3; Porphyra|Rep: 3-oxoacyl-[acyl-carrier-protein]
synthase 3 - Porphyra purpurea
Length = 326
Score = 42.7 bits (96), Expect = 0.010
Identities = 38/143 (26%), Positives = 57/143 (39%)
Frame = +3
Query: 132 VGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTALHRL 311
V IL+ P+ V+ + E E S + G K + + A +
Sbjct: 3 VHILSTGSSVPNFSVENQQFEDIIETSDHWISTRTGIKKRHLAPSSTSLTKLAAEAANDA 62
Query: 312 IDKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGGTAAL 491
+ K IN DI + + T T D S L A+ GAT D T AC G AL
Sbjct: 63 LSKASINAEDIDLIILATSTPDDLFGSASQ----LQAEIGATSSTAFDITAACSGFIIAL 118
Query: 492 FNAINWVESSSWDGRKAIVVAGD 560
A ++++ S++ K +VV D
Sbjct: 119 VTASQFIQAGSYN--KVLVVGAD 139
>UniRef50_Q81JG0 Cluster: 3-oxoacyl-[acyl-carrier-protein] synthase
3 protein 1; n=21; Bacteria|Rep:
3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 1 -
Bacillus anthracis
Length = 310
Score = 39.9 bits (89), Expect = 0.072
Identities = 44/195 (22%), Positives = 77/195 (39%), Gaps = 8/195 (4%)
Frame = +3
Query: 129 NVGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTALHR 308
NVGIL + Y P + V +LEK + S G ++ D D + + + A +
Sbjct: 2 NVGILGIGRYVPEKVVTNHDLEKIMDTSDEWIRTRTGIAERRIADDTIDTSYMAVEASKK 61
Query: 309 LIDKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGGTAA 488
++ I+ DI + V T T ++ + GA +D + AC G
Sbjct: 62 ALEDAGISGEDIDLILVATVT---PDRAFPAVACVIQEAIGAKHAAAMDLSAACAGFMYG 118
Query: 489 LFNAINWVESSSWDGRKAIVVAGD----IAVYGKGPARPTGGAGAVAMLIGP----DAPL 644
+ A ++++ ++ + +VV D I + G GA A+++G L
Sbjct: 119 MITAQQFIQTGTY--KNVLVVGSDKLSKIVDWNDRNTAVLFGDGAGAIVMGAVSEGKGVL 176
Query: 645 VFDCGVRASYMTHAY 689
F+ G S H Y
Sbjct: 177 SFELGADGSGGKHLY 191
>UniRef50_Q1VIJ1 Cluster: 3-hydroxy-3-methylglutaryl-coenzyme A
synthase; n=1; Psychroflexus torquis ATCC 700755|Rep:
3-hydroxy-3-methylglutaryl-coenzyme A synthase -
Psychroflexus torquis ATCC 700755
Length = 89
Score = 39.5 bits (88), Expect = 0.095
Identities = 24/81 (29%), Positives = 36/81 (44%)
Frame = +3
Query: 105 VNMGGKVENVGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINS 284
V G VG+ + ++ P Y+D E + E K GLG S M ED +
Sbjct: 9 VTSEGNSITVGVDDLAIHVPRLYLDMREFAELREADYDKLNKGLGLSAMAIPDVHEDTAT 68
Query: 285 ICLTALHRLIDKQKINLHDIG 347
+ A+ RLID+ ++ IG
Sbjct: 69 MGAMAVMRLIDRNGLDPRGIG 89
>UniRef50_Q97CG9 Cluster: UPF0219 protein TV0132; n=37; cellular
organisms|Rep: UPF0219 protein TV0132 - Thermoplasma
volcanium
Length = 351
Score = 39.5 bits (88), Expect = 0.095
Identities = 40/190 (21%), Positives = 77/190 (40%), Gaps = 1/190 (0%)
Frame = +3
Query: 135 GILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTALHRLI 314
GI+ Y P + E+ + + + G+ + ED+ +I + A +
Sbjct: 3 GIVTYGSYIPRYRIKPDEIARVWGENPERIKNGIFILSKSVPAPDEDVATISVEAARNAL 62
Query: 315 DKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGGTAALF 494
++KIN +IG + VG+E+ K T + + + + D AC GTA +
Sbjct: 63 KRKKINPKEIGAIYVGSESHPYAVKPTATIVGSAIGVD--FSLFAADYEFACKAGTAGMQ 120
Query: 495 NAINWVESSSWDGRKAIVVAGDIAVYGKGPA-RPTGGAGAVAMLIGPDAPLVFDCGVRAS 671
N V++ + + + D + G A + AG A +IG D ++ + S
Sbjct: 121 NVKAMVDAGMI--KYGLAIGADTSQGAPGDALEYSASAGGSAFIIGKD-DVIAEINSTLS 177
Query: 672 YMTHAYDFYK 701
+ DF++
Sbjct: 178 VASDTPDFWR 187
>UniRef50_A2Z2A6 Cluster: Putative uncharacterized protein; n=2;
Oryza sativa|Rep: Putative uncharacterized protein -
Oryza sativa subsp. indica (Rice)
Length = 980
Score = 35.9 bits (79), Expect = 1.2
Identities = 20/51 (39%), Positives = 27/51 (52%)
Frame = +3
Query: 495 NAINWVESSSWDGRKAIVVAGDIAVYGKGPARPTGGAGAVAMLIGPDAPLV 647
+ + W E ++ GR + VVAG A PA P+GGAG A AP+V
Sbjct: 6 DGVGW-EGATLTGRCSDVVAGAAAGVAAPPAAPSGGAGEAAAAAAEAAPVV 55
>UniRef50_Q9KET5 Cluster: 3-oxoacyl-[acyl-carrier-protein] synthase
3 protein 2; n=16; Bacillales|Rep:
3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2 -
Bacillus halodurans
Length = 332
Score = 35.5 bits (78), Expect = 1.5
Identities = 37/146 (25%), Positives = 61/146 (41%)
Frame = +3
Query: 123 VENVGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTAL 302
V I A+ Y P + + +LEK + + G + +D E + I A+
Sbjct: 3 VSKARITAIGSYVPERRLTNDDLEKMVDTNDEWIVKRTGIRERRIAADDEFTSDIGYKAV 62
Query: 303 HRLIDKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGGT 482
LI + + ++ D+ + V T T K+ S + + AK G + ID AC G T
Sbjct: 63 QDLIARYEKSVDDVDMIIVCTFTPDFKTPSAASLIQ---AKLGIQNTGAIDLNAACAGFT 119
Query: 483 AALFNAINWVESSSWDGRKAIVVAGD 560
L A + SS RK +V+ +
Sbjct: 120 YGLHMANGLI--SSGLHRKILVIGAE 143
>UniRef50_Q13PK8 Cluster: Putative uncharacterized protein; n=2;
Burkholderia xenovorans LB400|Rep: Putative
uncharacterized protein - Burkholderia xenovorans
(strain LB400)
Length = 182
Score = 35.1 bits (77), Expect = 2.0
Identities = 20/49 (40%), Positives = 28/49 (57%), Gaps = 1/49 (2%)
Frame = +3
Query: 483 AALFNAINWVESSSWDGRKAIVVAGDIAV-YGKGPARPTGGAGAVAMLI 626
+A F +N+V S++W G AI+V DIA+ Y P TG +V LI
Sbjct: 116 SAHFLHVNYVISAAWAGAFAILVLADIAMAYAPAPLHSTGVIASVIALI 164
>UniRef50_A4F133 Cluster: Putative uncharacterized protein; n=1;
Roseobacter sp. SK209-2-6|Rep: Putative uncharacterized
protein - Roseobacter sp. SK209-2-6
Length = 295
Score = 35.1 bits (77), Expect = 2.0
Identities = 19/67 (28%), Positives = 35/67 (52%), Gaps = 1/67 (1%)
Frame = +3
Query: 159 FPSQYVDQTELEKFDEVST-GKYTIGLGQSKMGFCSDREDINSICLTALHRLIDKQKINL 335
F ++++ ++ FD V+ KY + + + +G C RED+ + ++HR D K L
Sbjct: 105 FHQRFIETATVKNFDPVNRKSKYAL-MDTACVGQCRTREDLLLLTRVSMHRRQDFPKFEL 163
Query: 336 HDIGRLE 356
+GR E
Sbjct: 164 AGVGRQE 170
>UniRef50_UPI0000D5795B Cluster: PREDICTED: similar to CG12149-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG12149-PA - Tribolium castaneum
Length = 1083
Score = 33.9 bits (74), Expect = 4.7
Identities = 28/104 (26%), Positives = 46/104 (44%), Gaps = 2/104 (1%)
Frame = +3
Query: 96 QYTVNMGGK-VENVGILAMELYFPSQYVDQTELEKFDEVST-GKYTIGLGQSKMGFCSDR 269
Q N+ GK EN+ +L ++ +T LE D V T + + K+
Sbjct: 151 QQVANIAGKQTENI-VLYQDMTARDLIQQRTTLENGDTVWTLSPLVLAALEGKIAVLDGI 209
Query: 270 EDINSICLTALHRLIDKQKINLHDIGRLEVGTETIIDKSKSVKT 401
I+ L+ LHRL+ +++ LHD RL + K+K+ T
Sbjct: 210 HRIHPSTLSCLHRLVQNRELQLHDGKRLISHERYQLLKTKTTPT 253
>UniRef50_Q419Z7 Cluster: Beta-ketoacyl-acyl carrier protein
synthase III; n=1; Exiguobacterium sibiricum 255-15|Rep:
Beta-ketoacyl-acyl carrier protein synthase III -
Exiguobacterium sibiricum 255-15
Length = 314
Score = 33.5 bits (73), Expect = 6.2
Identities = 35/172 (20%), Positives = 65/172 (37%), Gaps = 4/172 (2%)
Frame = +3
Query: 129 NVGILAMELYFPSQYVDQTELEKFDEVSTGKYTIGLGQSKMGFCSDREDINSICLTALHR 308
N+GI+ + P + +L + S G D D+ + A +
Sbjct: 2 NIGIVGLGTSLPEHRMTNDDLAATLDTSDEWIRSRTGIGARRIADDAVDVTDLATEAAQK 61
Query: 309 LIDKQKINLHDIGRLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGGTAA 488
+ + DIG + VGT T ++ + + + GA D + AC G A
Sbjct: 62 ALADANLTADDIGLIVVGTAT----GRAFPSTACIVQERIGALGATAFDISAACSGFIFA 117
Query: 489 LFNAINWVESSSWDGRKAIVVAGD----IAVYGKGPARPTGGAGAVAMLIGP 632
L A + + ++ + A+V+ + I + G GA A+++GP
Sbjct: 118 LQTASSMMTATG--SKHALVIGAEKMSSIVDWSDRSTAILFGDGAGAVVLGP 167
>UniRef50_Q5ATB6 Cluster: Putative uncharacterized protein; n=1;
Emericella nidulans|Rep: Putative uncharacterized
protein - Emericella nidulans (Aspergillus nidulans)
Length = 461
Score = 33.5 bits (73), Expect = 6.2
Identities = 34/114 (29%), Positives = 50/114 (43%)
Frame = +3
Query: 372 IIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGGTAALFNAINWVESSSWDGRKAIVV 551
II + S+ TF+ F+ +T GI ++ + G A L +N + + W GRK V+
Sbjct: 28 IITSTISLPTFI-DYFSNPSSTVTGGIVSS---FQGGAILGTMVN-MAGADWAGRKMTVL 82
Query: 552 AGDIAVYGKGPARPTGGAGAVAMLIGPDAPLVFDCGVRASYMTHAYDFYKPDLS 713
AG I V G A G ++IG F GV +T Y +LS
Sbjct: 83 AGAI-VSVLGCALQAGAVNMTMLIIGR-----FIAGVAVGMLTSTIPMYAAELS 130
>UniRef50_UPI0000E4A4E5 Cluster: PREDICTED: similar to scavenger
receptor cysteine-rich protein precursor; n=3;
Strongylocentrotus purpuratus|Rep: PREDICTED: similar to
scavenger receptor cysteine-rich protein precursor -
Strongylocentrotus purpuratus
Length = 1020
Score = 33.1 bits (72), Expect = 8.2
Identities = 24/75 (32%), Positives = 36/75 (48%), Gaps = 6/75 (8%)
Frame = +3
Query: 258 CSDREDINSICLTALHRL--IDKQKINLHDIGRLEVGT----ETIIDKSKSVKTFLMTLF 419
C+ ED + IC+ RL + K K+ L D G L V E+ D +++ T L
Sbjct: 370 CAHNEDASVICIPKERRLTRLSKNKL-LEDEGELSVPKNPQCESTHDDIETIFTSKTALL 428
Query: 420 AKEGATDIEGIDTTN 464
AK+G+TD + N
Sbjct: 429 AKDGSTDAMSLSVEN 443
>UniRef50_Q8EY21 Cluster: NADH dehydrogenase; n=4; Leptospira|Rep:
NADH dehydrogenase - Leptospira interrogans
Length = 422
Score = 33.1 bits (72), Expect = 8.2
Identities = 16/34 (47%), Positives = 18/34 (52%)
Frame = +3
Query: 528 DGRKAIVVAGDIAVYGKGPARPTGGAGAVAMLIG 629
+G + V GDIA Y KG RP G VAM G
Sbjct: 292 EGHSEVFVIGDIASYSKGLERPLPGVSPVAMQQG 325
>UniRef50_A7LTP0 Cluster: Putative uncharacterized protein; n=1;
Bacteroides ovatus ATCC 8483|Rep: Putative
uncharacterized protein - Bacteroides ovatus ATCC 8483
Length = 594
Score = 33.1 bits (72), Expect = 8.2
Identities = 20/46 (43%), Positives = 28/46 (60%), Gaps = 1/46 (2%)
Frame = +3
Query: 429 GATD-IEGIDTTNACYGGTAALFNAINWVESSSWDGRKAIVVAGDI 563
GAT+ +E I +NAC G +AL A W+ES + ++ IV GDI
Sbjct: 139 GATNQVEVI--SNACISGVSALIVAKRWIESGRY--KRVIVAGGDI 180
>UniRef50_A4AX52 Cluster: Putative ABC-type transport system, ATPase
component; n=4; Gammaproteobacteria|Rep: Putative
ABC-type transport system, ATPase component -
Alteromonas macleodii 'Deep ecotype'
Length = 344
Score = 33.1 bits (72), Expect = 8.2
Identities = 24/70 (34%), Positives = 34/70 (48%), Gaps = 5/70 (7%)
Frame = +3
Query: 441 IEGIDTTNACYGGTAALFNAINWVE----SSSWDGRKAIVVAGDIAVYGKGPARPTGGA- 605
+E +DT ACY A+ F A E S+++D +A + GK P P GA
Sbjct: 205 LEQLDTPEACYSSPASRFVARFMGEASFLSATFDASEADTDKTVVTEIGKVPGTPLQGAN 264
Query: 606 GAVAMLIGPD 635
G V +L+ PD
Sbjct: 265 GNVDLLVRPD 274
>UniRef50_A3TWG2 Cluster: Methionine sulfoxide reductase B; n=1;
Oceanicola batsensis HTCC2597|Rep: Methionine sulfoxide
reductase B - Oceanicola batsensis HTCC2597
Length = 173
Score = 33.1 bits (72), Expect = 8.2
Identities = 24/68 (35%), Positives = 34/68 (50%), Gaps = 1/68 (1%)
Frame = +3
Query: 348 RLEVGTETIIDKSKSVKTFLMTLFAKEGATDIEGIDTTNACYGGTAALFNAIN-WVESSS 524
R + T T +D S SV L T E ATDIEG+D++ Y T + + W + +
Sbjct: 70 RADSQTVTEVDSSTSVPASLETSRLAE-ATDIEGMDSSREMYIWTMNDVDGVEPWSDEDA 128
Query: 525 WDGRKAIV 548
+ R AIV
Sbjct: 129 TEMRSAIV 136
>UniRef50_A3J8N4 Cluster: Hydrolase of the alpha/beta superfamily
protein; n=1; Marinobacter sp. ELB17|Rep: Hydrolase of
the alpha/beta superfamily protein - Marinobacter sp.
ELB17
Length = 370
Score = 33.1 bits (72), Expect = 8.2
Identities = 17/48 (35%), Positives = 26/48 (54%)
Frame = +3
Query: 498 AINWVESSSWDGRKAIVVAGDIAVYGKGPARPTGGAGAVAMLIGPDAP 641
A+NW+E S + GR+ ++ G + G+ AGA+ LI DAP
Sbjct: 178 AVNWIEQSRYSGRQRMMAEG---LSGQEIEAAEDAAGAINALIQSDAP 222
>UniRef50_Q6K4B4 Cluster: Putative uncharacterized protein
OJ1509_C06.33; n=1; Oryza sativa (japonica
cultivar-group)|Rep: Putative uncharacterized protein
OJ1509_C06.33 - Oryza sativa subsp. japonica (Rice)
Length = 83
Score = 33.1 bits (72), Expect = 8.2
Identities = 18/47 (38%), Positives = 24/47 (51%)
Frame = -3
Query: 661 TPQSNTRGASGPINIATAPAPPVGLAGPFP*TAMSPATTMAFLPSQD 521
+P T GA+ A +PAPP G AG A +PATT P ++
Sbjct: 4 SPWPPTTGAASAAAAAASPAPPEGAAGGAATPAAAPATTSEQRPVKE 50
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 760,920,999
Number of Sequences: 1657284
Number of extensions: 15234226
Number of successful extensions: 44003
Number of sequences better than 10.0: 54
Number of HSP's better than 10.0 without gapping: 41579
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 43851
length of database: 575,637,011
effective HSP length: 99
effective length of database: 411,565,895
effective search space used: 67496806780
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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