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Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= fcaL-P12_F_K21
         (714 letters)

Database: human 
           237,096 sequences; 76,859,062 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

X98093-1|CAA66719.1| 1239|Homo sapiens DNA polymerase gamma prot...    52   3e-06
U74651-1|AAB18268.1|  200|Homo sapiens DNA polymerase gamma prot...    52   3e-06
U60325-1|AAC50712.1| 1239|Homo sapiens DNA polymerase gamma prot...    52   3e-06
D84103-1|BAA12223.1| 1241|Homo sapiens mitochondrial DNA polymer...    52   3e-06
BC050559-1|AAH50559.1| 1239|Homo sapiens POLG protein protein.         52   3e-06
BC042571-1|AAH42571.1| 1239|Homo sapiens polymerase (DNA directe...    52   3e-06
AF497906-1|AAM77583.1| 1240|Homo sapiens polymerase (DNA directe...    52   3e-06
X83957-1|CAA58788.1| 6669|Homo sapiens nebulin protein.                33   1.0  
U35637-1|AAB02622.1| 3007|Homo sapiens nebulin protein.                33   1.0  
AC009497-1|AAY14651.1| 2802|Homo sapiens unknown protein.              33   1.0  
BC105958-1|AAI05959.1|  677|Homo sapiens ECM2 protein protein.         31   4.1  
BX537976-1|CAD97940.1|  693|Homo sapiens hypothetical protein pr...    31   5.4  
BC107493-1|AAI07494.1|  699|Homo sapiens extracellular matrix pr...    31   5.4  
AL157827-4|CAI12589.1|  699|Homo sapiens extracellular matrix pr...    31   5.4  
AL137848-1|CAI16693.1|  699|Homo sapiens extracellular matrix pr...    31   5.4  
AB011792-1|BAA33958.1|  699|Homo sapiens extracellular matrix pr...    31   5.4  
U30872-1|AAA82935.1| 3113|Homo sapiens mitosin protein.                30   9.5  
U19769-1|AAA82889.1| 3210|Homo sapiens CENP-F kinetochore protei...    30   9.5  
AL445666-1|CAH71810.1| 3114|Homo sapiens centromere protein F, 3...    30   9.5  
AL445305-6|CAH73032.1| 3114|Homo sapiens centromere protein F, 3...    30   9.5  

>X98093-1|CAA66719.1| 1239|Homo sapiens DNA polymerase gamma
           protein.
          Length = 1239

 Score = 51.6 bits (118), Expect = 3e-06
 Identities = 28/90 (31%), Positives = 53/90 (58%)
 Frame = +1

Query: 445 KKQKKRNDIPKVNNEEPNLSSELRVNEFNIQMISKNIYEQLFKKPSSSPDPEVIKSCQES 624
           ++Q+++   P+V + E     +LR N  +IQM+S+ ++EQ+F +    P    ++   E 
Sbjct: 50  QQQQQQPQQPQVLSSE---GGQLRHNPLDIQMLSRGLHEQIFGQGGEMPGEAAVRRSVEH 106

Query: 625 LLRHGIXYKKCSNYLPDVTLKLPKLXGQDI 714
           L +HG+ + + +  LPDV L+LP L G ++
Sbjct: 107 LQKHGL-WGQPAVPLPDVELRLPPLYGDNL 135


>U74651-1|AAB18268.1|  200|Homo sapiens DNA polymerase gamma
           protein.
          Length = 200

 Score = 51.6 bits (118), Expect = 3e-06
 Identities = 28/90 (31%), Positives = 53/90 (58%)
 Frame = +1

Query: 445 KKQKKRNDIPKVNNEEPNLSSELRVNEFNIQMISKNIYEQLFKKPSSSPDPEVIKSCQES 624
           ++Q+++   P+V + E     +LR N  +IQM+S+ ++EQ+F +    P    ++   E 
Sbjct: 50  QQQQQQPQQPQVLSSE---GGQLRHNPLDIQMLSRGLHEQIFGQGGEMPGEAAVRRSVEH 106

Query: 625 LLRHGIXYKKCSNYLPDVTLKLPKLXGQDI 714
           L +HG+ + + +  LPDV L+LP L G ++
Sbjct: 107 LQKHGL-WGQPAVPLPDVELRLPPLYGDNL 135


>U60325-1|AAC50712.1| 1239|Homo sapiens DNA polymerase gamma
           protein.
          Length = 1239

 Score = 51.6 bits (118), Expect = 3e-06
 Identities = 28/90 (31%), Positives = 53/90 (58%)
 Frame = +1

Query: 445 KKQKKRNDIPKVNNEEPNLSSELRVNEFNIQMISKNIYEQLFKKPSSSPDPEVIKSCQES 624
           ++Q+++   P+V + E     +LR N  +IQM+S+ ++EQ+F +    P    ++   E 
Sbjct: 50  QQQQQQPQQPQVLSSE---GGQLRHNPLDIQMLSRGLHEQIFGQGGEMPGEAAVRRSVEH 106

Query: 625 LLRHGIXYKKCSNYLPDVTLKLPKLXGQDI 714
           L +HG+ + + +  LPDV L+LP L G ++
Sbjct: 107 LQKHGL-WGQPAVPLPDVELRLPPLYGDNL 135


>D84103-1|BAA12223.1| 1241|Homo sapiens mitochondrial DNA polymerase
           gamma protein.
          Length = 1241

 Score = 51.6 bits (118), Expect = 3e-06
 Identities = 28/90 (31%), Positives = 53/90 (58%)
 Frame = +1

Query: 445 KKQKKRNDIPKVNNEEPNLSSELRVNEFNIQMISKNIYEQLFKKPSSSPDPEVIKSCQES 624
           ++Q+++   P+V + E     +LR N  +IQM+S+ ++EQ+F +    P    ++   E 
Sbjct: 52  QQQQQQPQQPQVLSSE---GGQLRHNPLDIQMLSRGLHEQIFGQGGEMPGEAAVRRSVEH 108

Query: 625 LLRHGIXYKKCSNYLPDVTLKLPKLXGQDI 714
           L +HG+ + + +  LPDV L+LP L G ++
Sbjct: 109 LQKHGL-WGQPAVPLPDVELRLPPLYGDNL 137


>BC050559-1|AAH50559.1| 1239|Homo sapiens POLG protein protein.
          Length = 1239

 Score = 51.6 bits (118), Expect = 3e-06
 Identities = 28/90 (31%), Positives = 53/90 (58%)
 Frame = +1

Query: 445 KKQKKRNDIPKVNNEEPNLSSELRVNEFNIQMISKNIYEQLFKKPSSSPDPEVIKSCQES 624
           ++Q+++   P+V + E     +LR N  +IQM+S+ ++EQ+F +    P    ++   E 
Sbjct: 50  QQQQQQPQQPQVLSSE---GGQLRHNPLDIQMLSRGLHEQIFGQGGEMPGEAAVRRSVEH 106

Query: 625 LLRHGIXYKKCSNYLPDVTLKLPKLXGQDI 714
           L +HG+ + + +  LPDV L+LP L G ++
Sbjct: 107 LQKHGL-WGQPAVPLPDVELRLPPLYGDNL 135


>BC042571-1|AAH42571.1| 1239|Homo sapiens polymerase (DNA directed),
           gamma protein.
          Length = 1239

 Score = 51.6 bits (118), Expect = 3e-06
 Identities = 28/90 (31%), Positives = 53/90 (58%)
 Frame = +1

Query: 445 KKQKKRNDIPKVNNEEPNLSSELRVNEFNIQMISKNIYEQLFKKPSSSPDPEVIKSCQES 624
           ++Q+++   P+V + E     +LR N  +IQM+S+ ++EQ+F +    P    ++   E 
Sbjct: 50  QQQQQQPQQPQVLSSE---GGQLRHNPLDIQMLSRGLHEQIFGQGGEMPGEAAVRRSVEH 106

Query: 625 LLRHGIXYKKCSNYLPDVTLKLPKLXGQDI 714
           L +HG+ + + +  LPDV L+LP L G ++
Sbjct: 107 LQKHGL-WGQPAVPLPDVELRLPPLYGDNL 135


>AF497906-1|AAM77583.1| 1240|Homo sapiens polymerase (DNA directed),
           gamma protein.
          Length = 1240

 Score = 51.6 bits (118), Expect = 3e-06
 Identities = 28/90 (31%), Positives = 53/90 (58%)
 Frame = +1

Query: 445 KKQKKRNDIPKVNNEEPNLSSELRVNEFNIQMISKNIYEQLFKKPSSSPDPEVIKSCQES 624
           ++Q+++   P+V + E     +LR N  +IQM+S+ ++EQ+F +    P    ++   E 
Sbjct: 51  QQQQQQPQQPQVLSSE---GGQLRHNPLDIQMLSRGLHEQIFGQGGEMPGEAAVRRSVEH 107

Query: 625 LLRHGIXYKKCSNYLPDVTLKLPKLXGQDI 714
           L +HG+ + + +  LPDV L+LP L G ++
Sbjct: 108 LQKHGL-WGQPAVPLPDVELRLPPLYGDNL 136


>X83957-1|CAA58788.1| 6669|Homo sapiens nebulin protein.
          Length = 6669

 Score = 33.1 bits (72), Expect = 1.0
 Identities = 22/86 (25%), Positives = 44/86 (51%)
 Frame = +1

Query: 367  SFLNKVNVGNQRFLSDVLPTTEFKVLKKQKKRNDIPKVNNEEPNLSSELRVNEFNIQMIS 546
            S L+  +  NQ+ L+  +   E    +K K    +P+  +++PN +  LRV + NI  + 
Sbjct: 4721 STLSLTHAKNQKHLASHIKYRE--EYEKFKALYTLPRSVDDDPNTARCLRVGKLNIDRLY 4778

Query: 547  KNIYEQLFKKPSSSPDPEVIKSCQES 624
            +++YE+   K    PD   + + ++S
Sbjct: 4779 RSVYEKNKMKIHIVPDMVEMVTAKDS 4804


>U35637-1|AAB02622.1| 3007|Homo sapiens nebulin protein.
          Length = 3007

 Score = 33.1 bits (72), Expect = 1.0
 Identities = 22/86 (25%), Positives = 44/86 (51%)
 Frame = +1

Query: 367  SFLNKVNVGNQRFLSDVLPTTEFKVLKKQKKRNDIPKVNNEEPNLSSELRVNEFNIQMIS 546
            S L+  +  NQ+ L+  +   E    +K K    +P+  +++PN +  LRV + NI  + 
Sbjct: 1152 STLSLTHAKNQKHLASHIKYRE--EYEKFKALYTLPRSVDDDPNTARCLRVGKLNIDRLY 1209

Query: 547  KNIYEQLFKKPSSSPDPEVIKSCQES 624
            +++YE+   K    PD   + + ++S
Sbjct: 1210 RSVYEKNKMKIHIVPDMVEMVTAKDS 1235


>AC009497-1|AAY14651.1| 2802|Homo sapiens unknown protein.
          Length = 2802

 Score = 33.1 bits (72), Expect = 1.0
 Identities = 22/86 (25%), Positives = 44/86 (51%)
 Frame = +1

Query: 367  SFLNKVNVGNQRFLSDVLPTTEFKVLKKQKKRNDIPKVNNEEPNLSSELRVNEFNIQMIS 546
            S L+  +  NQ+ L+  +   E    +K K    +P+  +++PN +  LRV + NI  + 
Sbjct: 854  STLSLTHAKNQKHLASHIKYRE--EYEKFKALYTLPRSVDDDPNTARCLRVGKLNIDRLY 911

Query: 547  KNIYEQLFKKPSSSPDPEVIKSCQES 624
            +++YE+   K    PD   + + ++S
Sbjct: 912  RSVYEKNKMKIHIVPDMVEMVTAKDS 937


>BC105958-1|AAI05959.1|  677|Homo sapiens ECM2 protein protein.
          Length = 677

 Score = 31.1 bits (67), Expect = 4.1
 Identities = 18/69 (26%), Positives = 35/69 (50%), Gaps = 4/69 (5%)
 Frame = +1

Query: 373 LNKVNVGNQRFLSDVLPTTEFKVLKKQKKRN----DIPKVNNEEPNLSSELRVNEFNIQM 540
           L ++++      S  +    FK+LKK  + N    ++ ++ ++ P+   EL+VNE N+Q 
Sbjct: 347 LERLDLSKNNITSSGIGPKAFKLLKKLMRSNMDGNNLIQIPSQLPSTLEELKVNENNLQA 406

Query: 541 ISKNIYEQL 567
           I +     L
Sbjct: 407 IDEESLSDL 415


>BX537976-1|CAD97940.1|  693|Homo sapiens hypothetical protein
           protein.
          Length = 693

 Score = 30.7 bits (66), Expect = 5.4
 Identities = 18/69 (26%), Positives = 35/69 (50%), Gaps = 4/69 (5%)
 Frame = +1

Query: 373 LNKVNVGNQRFLSDVLPTTEFKVLKKQKKRN----DIPKVNNEEPNLSSELRVNEFNIQM 540
           L ++++      S  +    FK+LKK  + N    ++ ++ ++ P+   EL+VNE N+Q 
Sbjct: 397 LERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQA 456

Query: 541 ISKNIYEQL 567
           I +     L
Sbjct: 457 IDEESLSDL 465


>BC107493-1|AAI07494.1|  699|Homo sapiens extracellular matrix
           protein 2, female organ and adipocyte specific protein.
          Length = 699

 Score = 30.7 bits (66), Expect = 5.4
 Identities = 18/69 (26%), Positives = 35/69 (50%), Gaps = 4/69 (5%)
 Frame = +1

Query: 373 LNKVNVGNQRFLSDVLPTTEFKVLKKQKKRN----DIPKVNNEEPNLSSELRVNEFNIQM 540
           L ++++      S  +    FK+LKK  + N    ++ ++ ++ P+   EL+VNE N+Q 
Sbjct: 369 LERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQA 428

Query: 541 ISKNIYEQL 567
           I +     L
Sbjct: 429 IDEESLSDL 437


>AL157827-4|CAI12589.1|  699|Homo sapiens extracellular matrix
           protein 2, female organ and adipocyte specific protein.
          Length = 699

 Score = 30.7 bits (66), Expect = 5.4
 Identities = 18/69 (26%), Positives = 35/69 (50%), Gaps = 4/69 (5%)
 Frame = +1

Query: 373 LNKVNVGNQRFLSDVLPTTEFKVLKKQKKRN----DIPKVNNEEPNLSSELRVNEFNIQM 540
           L ++++      S  +    FK+LKK  + N    ++ ++ ++ P+   EL+VNE N+Q 
Sbjct: 369 LERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQA 428

Query: 541 ISKNIYEQL 567
           I +     L
Sbjct: 429 IDEESLSDL 437


>AL137848-1|CAI16693.1|  699|Homo sapiens extracellular matrix
           protein 2, female organ and adipocyte specific protein.
          Length = 699

 Score = 30.7 bits (66), Expect = 5.4
 Identities = 18/69 (26%), Positives = 35/69 (50%), Gaps = 4/69 (5%)
 Frame = +1

Query: 373 LNKVNVGNQRFLSDVLPTTEFKVLKKQKKRN----DIPKVNNEEPNLSSELRVNEFNIQM 540
           L ++++      S  +    FK+LKK  + N    ++ ++ ++ P+   EL+VNE N+Q 
Sbjct: 369 LERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQA 428

Query: 541 ISKNIYEQL 567
           I +     L
Sbjct: 429 IDEESLSDL 437


>AB011792-1|BAA33958.1|  699|Homo sapiens extracellular matrix
           protein protein.
          Length = 699

 Score = 30.7 bits (66), Expect = 5.4
 Identities = 18/69 (26%), Positives = 35/69 (50%), Gaps = 4/69 (5%)
 Frame = +1

Query: 373 LNKVNVGNQRFLSDVLPTTEFKVLKKQKKRN----DIPKVNNEEPNLSSELRVNEFNIQM 540
           L ++++      S  +    FK+LKK  + N    ++ ++ ++ P+   EL+VNE N+Q 
Sbjct: 369 LERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQA 428

Query: 541 ISKNIYEQL 567
           I +     L
Sbjct: 429 IDEESLSDL 437


>U30872-1|AAA82935.1| 3113|Homo sapiens mitosin protein.
          Length = 3113

 Score = 29.9 bits (64), Expect = 9.5
 Identities = 28/123 (22%), Positives = 57/123 (46%), Gaps = 5/123 (4%)
 Frame = +1

Query: 277  RAVEKTRVRI*KFRMKKLH--KKIACINLKTHSFLNKVNVGNQRFLSDVLPTTEFKVLKK 450
            R +EK RVRI     K+LH  +K+     +  S  +KV    +R L       E  +L  
Sbjct: 2118 RGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVE-NLERELQMSEENQELVILDA 2176

Query: 451  QKKRNDIPKVNNEEPNLSSELRVNEFNIQMI---SKNIYEQLFKKPSSSPDPEVIKSCQE 621
            +  + ++  +  +   ++  L+V E ++  +    +N+ +Q+ +K     + + + S  +
Sbjct: 2177 ENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFK 2236

Query: 622  SLL 630
            SLL
Sbjct: 2237 SLL 2239


>U19769-1|AAA82889.1| 3210|Homo sapiens CENP-F kinetochore protein
            protein.
          Length = 3210

 Score = 29.9 bits (64), Expect = 9.5
 Identities = 28/123 (22%), Positives = 57/123 (46%), Gaps = 5/123 (4%)
 Frame = +1

Query: 277  RAVEKTRVRI*KFRMKKLH--KKIACINLKTHSFLNKVNVGNQRFLSDVLPTTEFKVLKK 450
            R +EK RVRI     K+LH  +K+     +  S  +KV    +R L       E  +L  
Sbjct: 2215 RGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVE-NLERELQMSEENQELVILDA 2273

Query: 451  QKKRNDIPKVNNEEPNLSSELRVNEFNIQMI---SKNIYEQLFKKPSSSPDPEVIKSCQE 621
            +  + ++  +  +   ++  L+V E ++  +    +N+ +Q+ +K     + + + S  +
Sbjct: 2274 ENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFK 2333

Query: 622  SLL 630
            SLL
Sbjct: 2334 SLL 2336


>AL445666-1|CAH71810.1| 3114|Homo sapiens centromere protein F,
            350/400ka (mitosin) protein.
          Length = 3114

 Score = 29.9 bits (64), Expect = 9.5
 Identities = 28/123 (22%), Positives = 57/123 (46%), Gaps = 5/123 (4%)
 Frame = +1

Query: 277  RAVEKTRVRI*KFRMKKLH--KKIACINLKTHSFLNKVNVGNQRFLSDVLPTTEFKVLKK 450
            R +EK RVRI     K+LH  +K+     +  S  +KV    +R L       E  +L  
Sbjct: 2119 RGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVE-NLERELQMSEENQELVILDA 2177

Query: 451  QKKRNDIPKVNNEEPNLSSELRVNEFNIQMI---SKNIYEQLFKKPSSSPDPEVIKSCQE 621
            +  + ++  +  +   ++  L+V E ++  +    +N+ +Q+ +K     + + + S  +
Sbjct: 2178 ENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFK 2237

Query: 622  SLL 630
            SLL
Sbjct: 2238 SLL 2240


>AL445305-6|CAH73032.1| 3114|Homo sapiens centromere protein F,
            350/400ka (mitosin) protein.
          Length = 3114

 Score = 29.9 bits (64), Expect = 9.5
 Identities = 28/123 (22%), Positives = 57/123 (46%), Gaps = 5/123 (4%)
 Frame = +1

Query: 277  RAVEKTRVRI*KFRMKKLH--KKIACINLKTHSFLNKVNVGNQRFLSDVLPTTEFKVLKK 450
            R +EK RVRI     K+LH  +K+     +  S  +KV    +R L       E  +L  
Sbjct: 2119 RGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVE-NLERELQMSEENQELVILDA 2177

Query: 451  QKKRNDIPKVNNEEPNLSSELRVNEFNIQMI---SKNIYEQLFKKPSSSPDPEVIKSCQE 621
            +  + ++  +  +   ++  L+V E ++  +    +N+ +Q+ +K     + + + S  +
Sbjct: 2178 ENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFK 2237

Query: 622  SLL 630
            SLL
Sbjct: 2238 SLL 2240


  Database: human
    Posted date:  Oct 23, 2007  1:18 PM
  Number of letters in database: 76,859,062
  Number of sequences in database:  237,096
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.279   0.0580    0.190 


Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 90,645,832
Number of Sequences: 237096
Number of extensions: 1803297
Number of successful extensions: 4185
Number of sequences better than 10.0: 20
Number of HSP's better than 10.0 without gapping: 4020
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4164
length of database: 76,859,062
effective HSP length: 88
effective length of database: 55,994,614
effective search space used: 8343197486
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)

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