Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fcaL-P12_F_B12
(692 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
X79440-1|CAA55956.1| 604|Homo sapiens malate dehydrogenase (oxa... 183 6e-46
M55905-1|AAA36197.1| 584|Homo sapiens mitochondrial NAD(P)+ -de... 182 1e-45
BC000147-1|AAH00147.1| 479|Homo sapiens ME2 protein protein. 182 1e-45
BC022472-1|AAH22472.1| 604|Homo sapiens malic enzyme 3, NADP(+)... 181 2e-45
X77244-1|CAA54460.1| 572|Homo sapiens malate dehydrogenase (oxa... 173 5e-43
U43944-1|AAC50613.1| 565|Homo sapiens cytosolic NADP(+)-depende... 173 5e-43
L34035-1|AAB01380.1| 572|Homo sapiens NADP-dependent malic enzy... 173 5e-43
BC025246-1|AAH25246.1| 572|Homo sapiens malic enzyme 1, NADP(+)... 173 5e-43
AL391416-2|CAH73129.1| 572|Homo sapiens malic enzyme 1, NADP(+)... 173 5e-43
AL136970-1|CAC19505.2| 572|Homo sapiens malic enzyme 1, NADP(+)... 173 5e-43
AL049699-1|CAI22634.1| 572|Homo sapiens malic enzyme 1, NADP(+)... 173 5e-43
AK223417-1|BAD97137.1| 572|Homo sapiens cytosolic malic enzyme ... 173 5e-43
AY424278-1|AAR04784.1| 259|Homo sapiens mitochondrial NADP(+)-d... 168 1e-41
AK092181-1|BAC03822.1| 252|Homo sapiens protein ( Homo sapiens ... 168 1e-41
AB045122-1|BAB40980.1| 44|Homo sapiens ME2 protein. 49 2e-05
>X79440-1|CAA55956.1| 604|Homo sapiens malate dehydrogenase
(oxaloacetate decarboxylating) (NADP+) protein.
Length = 604
Score = 183 bits (445), Expect = 6e-46
Identities = 84/141 (59%), Positives = 107/141 (75%)
Frame = +2
Query: 71 GLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIY 250
G D ++P LNKGMAFT+EER LGIHGL+PP +Q+ Q+ +R ++ L+KYI
Sbjct: 50 GYDVTRNPHLNKGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYII 109
Query: 251 LMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVY 430
LM L DRNE LFYR + +V + MPIVYTPTVGLACQ +GL +RRPRGLFITIHDKGH+
Sbjct: 110 LMTLQDRNEKLFYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHLA 169
Query: 431 DVLKNWPETDVRAIVVTDGER 493
+L +WPE +++A+VVTDGER
Sbjct: 170 TMLNSWPEDNIKAVVVTDGER 190
>M55905-1|AAA36197.1| 584|Homo sapiens mitochondrial NAD(P)+
-dependent malic enzyme protein.
Length = 584
Score = 182 bits (443), Expect = 1e-45
Identities = 76/135 (56%), Positives = 107/135 (79%)
Frame = +2
Query: 89 HPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGLLD 268
+P NKGMAFT++ERQ+LG+ GLLPP+++TQ+ Q ++ + +PL KYIY+MG+ +
Sbjct: 31 NPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQE 90
Query: 269 RNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLKNW 448
RNE LFYR + D++ +MPIVYTPTVGLAC ++G ++RRP+GLFI+I D+GHV ++ NW
Sbjct: 91 RNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNW 150
Query: 449 PETDVRAIVVTDGER 493
PE V+A+VVTDGER
Sbjct: 151 PENHVKAVVVTDGER 165
>BC000147-1|AAH00147.1| 479|Homo sapiens ME2 protein protein.
Length = 479
Score = 182 bits (443), Expect = 1e-45
Identities = 76/135 (56%), Positives = 107/135 (79%)
Frame = +2
Query: 89 HPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGLLD 268
+P NKGMAFT++ERQ+LG+ GLLPP+++TQ+ Q ++ + +PL KYIY+MG+ +
Sbjct: 31 NPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQE 90
Query: 269 RNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLKNW 448
RNE LFYR + D++ +MPIVYTPTVGLAC ++G ++RRP+GLFI+I D+GHV ++ NW
Sbjct: 91 RNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNW 150
Query: 449 PETDVRAIVVTDGER 493
PE V+A+VVTDGER
Sbjct: 151 PENHVKAVVVTDGER 165
>BC022472-1|AAH22472.1| 604|Homo sapiens malic enzyme 3,
NADP(+)-dependent, mitochondrial protein.
Length = 604
Score = 181 bits (440), Expect = 2e-45
Identities = 84/141 (59%), Positives = 106/141 (75%)
Frame = +2
Query: 71 GLDHLKHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIY 250
G D ++P LNKGMAFT+EER LGIHGL+PP Q+ Q+ +R ++ L+KYI
Sbjct: 50 GYDVTRNPHLNKGMAFTLEERLQLGIHGLIPPCFLGQDVQLLRIMGYYERQQSDLDKYII 109
Query: 251 LMGLLDRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVY 430
LM L DRNE LFYR + +V + MPIVYTPTVGLACQ +GL +RRPRGLFITIHDKGH+
Sbjct: 110 LMTLQDRNEKLFYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHLA 169
Query: 431 DVLKNWPETDVRAIVVTDGER 493
+L +WPE +++A+VVTDGER
Sbjct: 170 TMLNSWPEDNIKAVVVTDGER 190
>X77244-1|CAA54460.1| 572|Homo sapiens malate dehydrogenase
(oxaloacetate decarboxylating) (NADP+) protein.
Length = 572
Score = 173 bits (421), Expect = 5e-43
Identities = 78/136 (57%), Positives = 101/136 (74%)
Frame = +2
Query: 86 KHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGLL 265
++P LNK +AFT+EERQ L IHGLLPP +QE QV + + + ++Y+ LM L
Sbjct: 20 RNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYLLLMDLQ 79
Query: 266 DRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLKN 445
DRNE LFYR + ++ + MPIVYTPTVGLACQ++ LV+R+PRGLFITIHD+GH+ VL
Sbjct: 80 DRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDRGHIASVLNA 139
Query: 446 WPETDVRAIVVTDGER 493
WPE ++AIVVTDGER
Sbjct: 140 WPEDVIKAIVVTDGER 155
>U43944-1|AAC50613.1| 565|Homo sapiens cytosolic NADP(+)-dependent
malic enzyme protein.
Length = 565
Score = 173 bits (421), Expect = 5e-43
Identities = 78/136 (57%), Positives = 101/136 (74%)
Frame = +2
Query: 86 KHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGLL 265
++P LNK +AFT+EERQ L IHGLLPP +QE QV + + + ++Y+ LM L
Sbjct: 13 RNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYLLLMDLQ 72
Query: 266 DRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLKN 445
DRNE LFYR + ++ + MPIVYTPTVGLACQ++ LV+R+PRGLFITIHD+GH+ VL
Sbjct: 73 DRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDRGHIASVLNA 132
Query: 446 WPETDVRAIVVTDGER 493
WPE ++AIVVTDGER
Sbjct: 133 WPEDVIKAIVVTDGER 148
>L34035-1|AAB01380.1| 572|Homo sapiens NADP-dependent malic enzyme
protein.
Length = 572
Score = 173 bits (421), Expect = 5e-43
Identities = 78/136 (57%), Positives = 101/136 (74%)
Frame = +2
Query: 86 KHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGLL 265
++P LNK +AFT+EERQ L IHGLLPP +QE QV + + + ++Y+ LM L
Sbjct: 20 RNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYLLLMDLQ 79
Query: 266 DRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLKN 445
DRNE LFYR + ++ + MPIVYTPTVGLACQ++ LV+R+PRGLFITIHD+GH+ VL
Sbjct: 80 DRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDRGHIASVLNA 139
Query: 446 WPETDVRAIVVTDGER 493
WPE ++AIVVTDGER
Sbjct: 140 WPEDVIKAIVVTDGER 155
>BC025246-1|AAH25246.1| 572|Homo sapiens malic enzyme 1,
NADP(+)-dependent, cytosolic protein.
Length = 572
Score = 173 bits (421), Expect = 5e-43
Identities = 78/136 (57%), Positives = 101/136 (74%)
Frame = +2
Query: 86 KHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGLL 265
++P LNK +AFT+EERQ L IHGLLPP +QE QV + + + ++Y+ LM L
Sbjct: 20 RNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYLLLMDLQ 79
Query: 266 DRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLKN 445
DRNE LFYR + ++ + MPIVYTPTVGLACQ++ LV+R+PRGLFITIHD+GH+ VL
Sbjct: 80 DRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDRGHIASVLNA 139
Query: 446 WPETDVRAIVVTDGER 493
WPE ++AIVVTDGER
Sbjct: 140 WPEDVIKAIVVTDGER 155
>AL391416-2|CAH73129.1| 572|Homo sapiens malic enzyme 1,
NADP(+)-dependent, cytosolic protein.
Length = 572
Score = 173 bits (421), Expect = 5e-43
Identities = 78/136 (57%), Positives = 101/136 (74%)
Frame = +2
Query: 86 KHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGLL 265
++P LNK +AFT+EERQ L IHGLLPP +QE QV + + + ++Y+ LM L
Sbjct: 20 RNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYLLLMDLQ 79
Query: 266 DRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLKN 445
DRNE LFYR + ++ + MPIVYTPTVGLACQ++ LV+R+PRGLFITIHD+GH+ VL
Sbjct: 80 DRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDRGHIASVLNA 139
Query: 446 WPETDVRAIVVTDGER 493
WPE ++AIVVTDGER
Sbjct: 140 WPEDVIKAIVVTDGER 155
>AL136970-1|CAC19505.2| 572|Homo sapiens malic enzyme 1,
NADP(+)-dependent, cytosolic protein.
Length = 572
Score = 173 bits (421), Expect = 5e-43
Identities = 78/136 (57%), Positives = 101/136 (74%)
Frame = +2
Query: 86 KHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGLL 265
++P LNK +AFT+EERQ L IHGLLPP +QE QV + + + ++Y+ LM L
Sbjct: 20 RNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYLLLMDLQ 79
Query: 266 DRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLKN 445
DRNE LFYR + ++ + MPIVYTPTVGLACQ++ LV+R+PRGLFITIHD+GH+ VL
Sbjct: 80 DRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDRGHIASVLNA 139
Query: 446 WPETDVRAIVVTDGER 493
WPE ++AIVVTDGER
Sbjct: 140 WPEDVIKAIVVTDGER 155
>AL049699-1|CAI22634.1| 572|Homo sapiens malic enzyme 1,
NADP(+)-dependent, cytosolic protein.
Length = 572
Score = 173 bits (421), Expect = 5e-43
Identities = 78/136 (57%), Positives = 101/136 (74%)
Frame = +2
Query: 86 KHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGLL 265
++P LNK +AFT+EERQ L IHGLLPP +QE QV + + + ++Y+ LM L
Sbjct: 20 RNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYLLLMDLQ 79
Query: 266 DRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLKN 445
DRNE LFYR + ++ + MPIVYTPTVGLACQ++ LV+R+PRGLFITIHD+GH+ VL
Sbjct: 80 DRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDRGHIASVLNA 139
Query: 446 WPETDVRAIVVTDGER 493
WPE ++AIVVTDGER
Sbjct: 140 WPEDVIKAIVVTDGER 155
>AK223417-1|BAD97137.1| 572|Homo sapiens cytosolic malic enzyme 1
variant protein.
Length = 572
Score = 173 bits (421), Expect = 5e-43
Identities = 78/136 (57%), Positives = 101/136 (74%)
Frame = +2
Query: 86 KHPGLNKGMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGLL 265
++P LNK +AFT+EERQ L IHGLLPP +QE QV + + + ++Y+ LM L
Sbjct: 20 RNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYLLLMDLQ 79
Query: 266 DRNEHLFYRFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLKN 445
DRNE LFYR + ++ + MPIVYTPTVGLACQ++ LV+R+PRGLFITIHD+GH+ VL
Sbjct: 80 DRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDRGHIASVLNA 139
Query: 446 WPETDVRAIVVTDGER 493
WPE ++AIVVTDGER
Sbjct: 140 WPEDVIKAIVVTDGER 155
>AY424278-1|AAR04784.1| 259|Homo sapiens mitochondrial
NADP(+)-dependent malic enzyme 3 protein.
Length = 259
Score = 168 bits (409), Expect = 1e-41
Identities = 77/128 (60%), Positives = 98/128 (76%)
Frame = +2
Query: 110 MAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGLLDRNEHLFY 289
MAFT+EER LGIHGL+PP +Q+ Q+ +R ++ L+KYI LM L DRNE LFY
Sbjct: 1 MAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYIILMTLQDRNEKLFY 60
Query: 290 RFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLKNWPETDVRA 469
R + +V + MPIVYTPTVGLACQ +GL +RRPRGLFITIHDKGH+ +L +WPE +++A
Sbjct: 61 RVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHLATMLNSWPEDNIKA 120
Query: 470 IVVTDGER 493
+VVTDGER
Sbjct: 121 VVVTDGER 128
>AK092181-1|BAC03822.1| 252|Homo sapiens protein ( Homo sapiens
cDNA FLJ34862 fis, clone NT2NE2013547, highly similar to
NADP-DEPENDENT MALIC ENZYME, MITOCHONDRIAL PRECURSOR (EC
1.1.1.40). ).
Length = 252
Score = 168 bits (409), Expect = 1e-41
Identities = 77/128 (60%), Positives = 98/128 (76%)
Frame = +2
Query: 110 MAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPLNKYIYLMGLLDRNEHLFY 289
MAFT+EER LGIHGL+PP +Q+ Q+ +R ++ L+KYI LM L DRNE LFY
Sbjct: 1 MAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYIILMTLQDRNEKLFY 60
Query: 290 RFVADNVAEMMPIVYTPTVGLACQKFGLVYRRPRGLFITIHDKGHVYDVLKNWPETDVRA 469
R + +V + MPIVYTPTVGLACQ +GL +RRPRGLFITIHDKGH+ +L +WPE +++A
Sbjct: 61 RVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHLATMLNSWPEDNIKA 120
Query: 470 IVVTDGER 493
+VVTDGER
Sbjct: 121 VVVTDGER 128
>AB045122-1|BAB40980.1| 44|Homo sapiens ME2 protein.
Length = 44
Score = 48.8 bits (111), Expect = 2e-05
Identities = 20/43 (46%), Positives = 32/43 (74%)
Frame = +2
Query: 107 GMAFTIEERQLLGIHGLLPPRVKTQEEQVELCKLSIDRYENPL 235
GMAFT++ERQ+LG+ GLLPP+++TQ+ Q ++ + +PL
Sbjct: 1 GMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPL 43
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 104,651,545
Number of Sequences: 237096
Number of extensions: 2375194
Number of successful extensions: 5449
Number of sequences better than 10.0: 15
Number of HSP's better than 10.0 without gapping: 5186
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5449
length of database: 76,859,062
effective HSP length: 88
effective length of database: 55,994,614
effective search space used: 7951235188
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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