Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fcaL-P11_F_I19
(813 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;... 305 8e-82
UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 236 6e-61
UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 200 3e-50
UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella ve... 193 5e-48
UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 190 3e-47
UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulato... 190 5e-47
UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 188 1e-46
UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulato... 188 1e-46
UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p... 182 7e-45
UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8; Bilateri... 178 2e-43
UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalyti... 178 2e-43
UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3; Bacteria... 164 2e-39
UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 153 5e-36
UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate... 152 9e-36
UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]... 152 1e-35
UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 146 4e-34
UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421, ... 129 7e-29
UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate dehydrog... 124 4e-27
UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 118 2e-25
UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2; Bacteria... 116 5e-25
UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep: C... 115 1e-24
UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68; Bacteri... 114 3e-24
UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9; Eut... 114 3e-24
UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependen... 107 2e-22
UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD] s... 107 4e-22
UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]... 105 1e-21
UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3; Ricketts... 104 3e-21
UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8; E... 103 5e-21
UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6; E... 103 5e-21
UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma... 101 2e-20
UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6; T... 100 9e-20
UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10; ... 96 1e-18
UniRef50_Q4UKR1 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 95 1e-18
UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate dehydrog... 94 4e-18
UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenas... 93 8e-18
UniRef50_Q2UP37 Cluster: Isocitrate/isopropylmalate dehydrogenas... 89 1e-16
UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3; P... 79 2e-13
UniRef50_Q9RTT2 Cluster: Isocitrate dehydrogenase, putative; n=2... 77 4e-13
UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1... 77 7e-13
UniRef50_Q58991 Cluster: Threo-isocitrate dehydrogenase [NAD]; n... 77 7e-13
UniRef50_Q8XSY8 Cluster: Probable 3-isopropylmalate dehydrogenas... 76 9e-13
UniRef50_A5DIP6 Cluster: Putative uncharacterized protein; n=1; ... 76 9e-13
UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 75 2e-12
UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;... 75 3e-12
UniRef50_Q13FQ0 Cluster: Tartrate dehydrogenase; n=3; Proteobact... 74 5e-12
UniRef50_O29610 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 73 7e-12
UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5; T... 73 9e-12
UniRef50_Q8U299 Cluster: 3-isopropylmalate dehydrogenase 2; n=3;... 72 2e-11
UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 72 2e-11
UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;... 70 8e-11
UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9; B... 69 2e-10
UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5; C... 68 2e-10
UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2; Alp... 67 4e-10
UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;... 67 4e-10
UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependen... 67 4e-10
UniRef50_Q4V533 Cluster: IP13250p; n=4; Drosophila melanogaster|... 66 8e-10
UniRef50_Q44471 Cluster: Probable tartrate dehydrogenase/decarbo... 64 3e-09
UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase; n... 64 4e-09
UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1; S... 63 7e-09
UniRef50_A1SM34 Cluster: 3-isopropylmalate dehydrogenase; n=1; N... 62 2e-08
UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase, mitochond... 62 2e-08
UniRef50_Q5HNL1 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 62 2e-08
UniRef50_Q0X0C1 Cluster: Putative dehydrogenase; n=1; Streptomyc... 62 2e-08
UniRef50_Q0W1Q6 Cluster: 2-isopropylmalate dehydrogenase; n=5; E... 61 4e-08
UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1; Ent... 60 5e-08
UniRef50_Q8FPV5 Cluster: 3-isopropylmalate dehydrogenase; n=50; ... 59 1e-07
UniRef50_Q2Q9C5 Cluster: Isocitrate dehydrogenase 3 gamma; n=8; ... 58 2e-07
UniRef50_A6PN62 Cluster: 3-isopropylmalate dehydrogenase; n=1; V... 58 3e-07
UniRef50_Q6L2P9 Cluster: Isocitrate dehydrogenase [NADP]; n=2; T... 57 5e-07
UniRef50_Q67LW7 Cluster: Tartrate dehydrogenase; n=2; Bacteria|R... 56 1e-06
UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2; Bacillacea... 56 1e-06
UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 56 1e-06
UniRef50_A7GLU7 Cluster: Tartrate dehydrogenase; n=3; Bacteria|R... 55 2e-06
UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for ... 55 2e-06
UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: Leu... 52 2e-05
UniRef50_Q8DTG3 Cluster: 3-isopropylmalate dehydrogenase; n=41; ... 50 7e-05
UniRef50_P41566 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 42 8e-05
UniRef50_Q7UTP0 Cluster: 3-isopropylmalate dehydrogenase; n=2; B... 48 2e-04
UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular ... 48 3e-04
UniRef50_A0P1S6 Cluster: 3-isopropylmalate dehydrogenase; n=2; R... 48 3e-04
UniRef50_Q81T67 Cluster: 3-isopropylmalate dehydrogenase; n=9; B... 46 9e-04
UniRef50_Q9CKK6 Cluster: Idp; n=2; Pasteurellaceae|Rep: Idp - Pa... 44 0.003
UniRef50_Q0W5L4 Cluster: 3-isopropylmalate dehydrogenase; n=10; ... 34 0.006
UniRef50_Q89RJ1 Cluster: 3-isopropylmalate dehydrogenase; n=7; A... 43 0.011
UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 42 0.014
UniRef50_A6G3V7 Cluster: Probable 3-isopropylmalate dehydrogenas... 42 0.018
UniRef50_Q8A6M0 Cluster: 3-isopropylmalate dehydrogenase; n=42; ... 42 0.024
UniRef50_P56471 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 41 0.043
UniRef50_Q2VF40 Cluster: Isocitrate dehydrogenase 3 gamma subuni... 39 0.13
UniRef50_A5URE6 Cluster: Isocitrate dehydrogenase, NADP-dependen... 38 0.30
UniRef50_Q5IWY1 Cluster: Plastid 3-isopropylmalate dehydrogenase... 37 0.53
UniRef50_Q6L0K7 Cluster: 3-isopropylmalate dehydrogenase; n=2; T... 37 0.53
UniRef50_Q7UIE1 Cluster: 3-isopropylmalate dehydrogenase; n=4; B... 37 0.70
UniRef50_Q973N4 Cluster: Putative uncharacterized protein ST0866... 36 0.92
UniRef50_A5ADY5 Cluster: Putative uncharacterized protein; n=6; ... 36 1.2
UniRef50_Q54WR2 Cluster: Putative uncharacterized protein; n=2; ... 36 1.2
UniRef50_A0T6C0 Cluster: Putative uncharacterized protein; n=1; ... 34 3.7
UniRef50_A5BJM5 Cluster: Putative uncharacterized protein; n=8; ... 34 3.7
UniRef50_Q89XA0 Cluster: 3-isopropylmalate dehydrogenase 1; n=3;... 34 3.7
UniRef50_P56472 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 34 3.7
UniRef50_UPI0000F215F2 Cluster: PREDICTED: hypothetical protein;... 34 4.9
UniRef50_Q0M010 Cluster: FAD dependent oxidoreductase; n=9; Prot... 34 4.9
UniRef50_Q9LTT4 Cluster: WD domain protein-like; n=5; Magnolioph... 34 4.9
UniRef50_A5BSB2 Cluster: Putative uncharacterized protein; n=2; ... 34 4.9
UniRef50_A5E2P5 Cluster: Putative uncharacterized protein; n=1; ... 34 4.9
UniRef50_Q7SG44 Cluster: Putative uncharacterized protein NCU074... 33 8.6
UniRef50_Q12592 Cluster: 3-isopropylmalate dehydrogenase; n=3; A... 33 8.6
>UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;
Glossina morsitans morsitans|Rep: Isocitrate
dehydrogenase (NAD+) 2 - Glossina morsitans morsitans
(Savannah tsetse fly)
Length = 372
Score = 305 bits (749), Expect = 8e-82
Identities = 143/191 (74%), Positives = 162/191 (84%)
Frame = +3
Query: 240 PRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVV 419
P A R CTLIPGDGVGPELV +QEVFK+A +PVDFE +F SEVNP LSA LEDV+
Sbjct: 32 PGALGGNRTTCTLIPGDGVGPELVQCLQEVFKSADVPVDFECYFLSEVNPVLSAKLEDVI 91
Query: 420 NSIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDC 599
SI NK+CIKG+LATPD+S+ GELQ+LNMKLRN LDLYANVVH +SLP VK R+QD+D
Sbjct: 92 ASIRKNKVCIKGVLATPDYSNVGELQSLNMKLRNELDLYANVVHARSLPGVKTRYQDIDI 151
Query: 600 IIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKAN 779
++IREQTEGEYSALEHESVPG+VECLKIITA KS RIAKFAFDYA+ RKKVT+VHKAN
Sbjct: 152 VVIREQTEGEYSALEHESVPGIVECLKIITAKKSMRIAKFAFDYAIKNSRKKVTSVHKAN 211
Query: 780 IMXLGDGLFLR 812
IM LGDGLFL+
Sbjct: 212 IMKLGDGLFLK 222
>UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit
beta, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=61;
Fungi/Metazoa group|Rep: Isocitrate dehydrogenase [NAD]
subunit beta, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 385
Score = 236 bits (577), Expect = 6e-61
Identities = 116/187 (62%), Positives = 143/187 (76%), Gaps = 1/187 (0%)
Frame = +3
Query: 255 EGRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEV-NPTLSAPLEDVVNSIA 431
EG T++PGDGVGPEL++AV+EVFKAA++PV+F+ SEV N LE V++S+
Sbjct: 46 EGSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMK 105
Query: 432 VNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIR 611
NK+ I G + TP + GEL + +M+LR LDL+ANVVHVKSLP RH ++D +IIR
Sbjct: 106 ENKVAIIGKIHTP-MEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIR 164
Query: 612 EQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKANIMXL 791
EQTEGEYS+LEHES GV+ECLKI+T AKS+RIAKFAFDYA GR KVTAVHKANIM L
Sbjct: 165 EQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKL 224
Query: 792 GDGLFLR 812
GDGLFL+
Sbjct: 225 GDGLFLQ 231
>UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=50;
Deuterostomia|Rep: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 393
Score = 200 bits (489), Expect = 3e-50
Identities = 108/196 (55%), Positives = 138/196 (70%), Gaps = 3/196 (1%)
Frame = +3
Query: 234 LQPRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLED 413
+ P A GR T+IPGDG+GPEL+ V+ VF+ A +PVDFE EV+ + +A ED
Sbjct: 45 IPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFE-----EVHVSSNADEED 99
Query: 414 VVNSIAV---NKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRH 584
+ N+I N++ +KG + T + + ++ N LR +LDLYANV+H KSLP V RH
Sbjct: 100 IRNAIMAIRRNRVALKGNIET-NHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRH 158
Query: 585 QDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTA 764
+D+D +I+RE TEGEYS+LEHESV GVVE LKIIT AKS RIA++AF A GRKKVTA
Sbjct: 159 KDIDILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTA 218
Query: 765 VHKANIMXLGDGLFLR 812
VHKANIM LGDGLFL+
Sbjct: 219 VHKANIMKLGDGLFLQ 234
>UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 394
Score = 193 bits (470), Expect = 5e-48
Identities = 101/216 (46%), Positives = 140/216 (64%), Gaps = 4/216 (1%)
Frame = +3
Query: 177 VHTSSVTTEKNVCYAPFGALQPRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPVD 356
V + +KN+ Y P + P A GR TLIPGDG+GPE+V AVQ++F+ +PVD
Sbjct: 23 VRAAPQVIKKNLAYHPHH-VPPPARYGGRNTVTLIPGDGIGPEMVVAVQDIFRHIGVPVD 81
Query: 357 FESFFFSEVN----PTLSAPLEDVVNSIAVNKICIKGILATPDFSHTGELQTLNMKLRNA 524
FE S ++ + + + SI N + +KG + TP + G ++LN++LR
Sbjct: 82 FEELNLSGLDIKDEDSYLGAFNEAITSIKRNGVAMKGNIFTPLDAIPG-FRSLNLELRVH 140
Query: 525 LDLYANVVHVKSLPNVKCRHQDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSE 704
LDL+AN+V KS+P ++ RH +VD +IIR+ TEGEYS LEHE+V GV+E LK+ T
Sbjct: 141 LDLFANIVRCKSIPGIQTRHNNVDLVIIRQNTEGEYSHLEHENVSGVIENLKVTTEEACM 200
Query: 705 RIAKFAFDYAVXMGRKKVTAVHKANIMXLGDGLFLR 812
+IA++AFD+A RKKVTAVHKANIM +GDGLFLR
Sbjct: 201 KIAQYAFDFAEKHDRKKVTAVHKANIMKMGDGLFLR 236
>UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1;
Kluyveromyces lactis|Rep: Isocitrate dehydrogenase [NAD]
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Kluyveromyces lactis (Yeast) (Candida sphaerica)
Length = 361
Score = 190 bits (464), Expect = 3e-47
Identities = 101/183 (55%), Positives = 129/183 (70%)
Frame = +3
Query: 258 GRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAVN 437
GR TLIPGDGVG E+ +V ++F+ +IP+D+E+ S + T + ++ V S+ N
Sbjct: 28 GRYTVTLIPGDGVGKEVTDSVVKIFENENIPIDWETIDISGLENTEN--VQRAVESLKRN 85
Query: 438 KICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQ 617
K+ +KGI TP TG +LN+ LR LD++ANV KS+P VK R ++D +IIRE
Sbjct: 86 KVGLKGIWHTPA-DQTGH-GSLNVALRKQLDIFANVALFKSIPGVKTRLNNIDMVIIREN 143
Query: 618 TEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKANIMXLGD 797
TEGEYS LEHESVPGVVE LKI+T AKSERIA+FAFD+A+ RK V AVHKANIM LGD
Sbjct: 144 TEGEYSGLEHESVPGVVESLKIMTRAKSERIARFAFDFALKNNRKSVCAVHKANIMKLGD 203
Query: 798 GLF 806
GLF
Sbjct: 204 GLF 206
>UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 3, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 3) (NAD(+)-specific ICDH 3);
n=23; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 3, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 3) (NAD(+)-specific
ICDH 3) - Arabidopsis thaliana (Mouse-ear cress)
Length = 368
Score = 190 bits (462), Expect = 5e-47
Identities = 97/179 (54%), Positives = 128/179 (71%)
Frame = +3
Query: 273 TLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAVNKICIK 452
TLIPGDG+GP + AV++V +A PV FE + EV + E+V+ S+ NK+C+K
Sbjct: 42 TLIPGDGIGPLVTGAVEQVMEAMHAPVHFERY---EVLGNMRKVPEEVIESVKRNKVCLK 98
Query: 453 GILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQTEGEY 632
G LATP G + +LNM+LR LD++A++V+ ++P + RH++VD ++IRE TEGEY
Sbjct: 99 GGLATPV---GGGVSSLNMQLRKELDIFASLVNCINVPGLVTRHENVDIVVIRENTEGEY 155
Query: 633 SALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKANIMXLGDGLFL 809
S LEHE VPGVVE LK+IT SERIA++AF+YA RKKVTAVHKANIM L DGLFL
Sbjct: 156 SGLEHEVVPGVVESLKVITKFCSERIARYAFEYAYLNNRKKVTAVHKANIMKLADGLFL 214
>UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=32;
Dikarya|Rep: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 360
Score = 188 bits (459), Expect = 1e-46
Identities = 99/183 (54%), Positives = 126/183 (68%)
Frame = +3
Query: 258 GRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAVN 437
GR TLIPGDGVG E+ +V+ +F+A +IP+D+E+ + + + + V S+ N
Sbjct: 27 GRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDH--KEGVYEAVESLKRN 84
Query: 438 KICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQ 617
KI +KG+ TP TG +LN+ LR LD+YANV KSL VK R D+D I+IRE
Sbjct: 85 KIGLKGLWHTPA-DQTGH-GSLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIREN 142
Query: 618 TEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKANIMXLGD 797
TEGE+S LEHESVPGVVE LK++T K+ERIA+FAFD+A RK VTAVHKANIM LGD
Sbjct: 143 TEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLGD 202
Query: 798 GLF 806
GLF
Sbjct: 203 GLF 205
>UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 1) (NAD(+)-specific ICDH 1);
n=7; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 1, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 1) (NAD(+)-specific
ICDH 1) - Arabidopsis thaliana (Mouse-ear cress)
Length = 367
Score = 188 bits (459), Expect = 1e-46
Identities = 108/215 (50%), Positives = 141/215 (65%), Gaps = 1/215 (0%)
Frame = +3
Query: 168 GKGVHTSSVTTEKNVCYAPF-GALQPRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAAS 344
G G+ T SVT Y P G PRA TLIPGDG+GP + AV++V +A
Sbjct: 18 GSGIQTRSVT------YMPRPGDGAPRAV-------TLIPGDGIGPLVTNAVEQVMEAMH 64
Query: 345 IPVDFESFFFSEVNPTLSAPLEDVVNSIAVNKICIKGILATPDFSHTGELQTLNMKLRNA 524
P+ FE + +V+ +S +V+ SI NK+C+KG L TP G + +LN++LR
Sbjct: 65 APIFFEKY---DVHGEMSRVPPEVMESIRKNKVCLKGGLKTPV---GGGVSSLNVQLRKE 118
Query: 525 LDLYANVVHVKSLPNVKCRHQDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSE 704
LDL+A++V+ +LP + RH++VD ++IRE TEGEY+ LEHE VPGVVE LK+IT SE
Sbjct: 119 LDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYAGLEHEVVPGVVESLKVITKFCSE 178
Query: 705 RIAKFAFDYAVXMGRKKVTAVHKANIMXLGDGLFL 809
RIAK+AF+YA RKKVTAVHKANIM L DGLFL
Sbjct: 179 RIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFL 213
>UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p -
Drosophila melanogaster (Fruit fly)
Length = 402
Score = 182 bits (444), Expect = 7e-45
Identities = 89/192 (46%), Positives = 127/192 (66%), Gaps = 2/192 (1%)
Frame = +3
Query: 240 PRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSA--PLED 413
P A GR T++PG G+GPEL+ V+E+F+ P+DFE +++P+ L+
Sbjct: 50 PSAQYGGRHAVTMLPGGGIGPELMGYVREIFRYCGAPIDFEVI---DIDPSTEGNDDLDY 106
Query: 414 VVNSIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDV 593
+ SI N + +KG + T S T E+ N+ +RN LDLY NVVH KS P + RH D+
Sbjct: 107 AITSIKRNGVALKGNIETKSQSLT-EVSR-NVAIRNELDLYVNVVHCKSYPGIPARHHDI 164
Query: 594 DCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHK 773
D ++IR+ T+GEY+ LEHESVPG+VE +K++T +ER+A++AF++A RKKVT +HK
Sbjct: 165 DVVLIRQNTDGEYAMLEHESVPGIVESMKVVTVENAERVARYAFEFARQNNRKKVTTIHK 224
Query: 774 ANIMXLGDGLFL 809
ANIM L DGLFL
Sbjct: 225 ANIMKLSDGLFL 236
>UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8;
Bilateria|Rep: Isocitrate dehydrogenase - Aedes aegypti
(Yellowfever mosquito)
Length = 393
Score = 178 bits (433), Expect = 2e-43
Identities = 92/192 (47%), Positives = 126/192 (65%), Gaps = 2/192 (1%)
Frame = +3
Query: 240 PRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSA--PLED 413
P+A GR T++PG G+GPEL+ V+EVF+ A +PVDFE +++P LE
Sbjct: 42 PKAHYGGRHTVTMLPGGGIGPELMNYVKEVFRFAGVPVDFEVV---DIDPASEGNDDLEY 98
Query: 414 VVNSIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDV 593
+ SI N + +KG + T + TG + N+ LRN LDLY NV+H KS + HQ+V
Sbjct: 99 AITSIKRNGVALKGNIETKSEA-TGIISR-NVALRNELDLYVNVLHCKSFNAIPAHHQNV 156
Query: 594 DCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHK 773
D +IIR+ TEGEY+ LEHESV GVVE +K++T + R+A++AF++A RKKVT +HK
Sbjct: 157 DVVIIRQNTEGEYAMLEHESVRGVVESMKVVTVENAARVARYAFEFARANNRKKVTTIHK 216
Query: 774 ANIMXLGDGLFL 809
ANIM L DGLFL
Sbjct: 217 ANIMKLADGLFL 228
>UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalytic
subunit 6, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 6) (NAD(+)-specific ICDH 6);
n=10; cellular organisms|Rep: Isocitrate dehydrogenase
[NAD] catalytic subunit 6, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 6) (NAD(+)-specific
ICDH 6) - Arabidopsis thaliana (Mouse-ear cress)
Length = 374
Score = 178 bits (433), Expect = 2e-43
Identities = 98/185 (52%), Positives = 127/185 (68%), Gaps = 2/185 (1%)
Frame = +3
Query: 264 IKCTLIPGDGVGPELVYAVQEVFKAASIPVDF-ESFFFSEVNPTLSAPLE-DVVNSIAVN 437
IK TL PGDG+GPE+ +V++VF AA + +D+ E F +EV+P ++ L D + S+ N
Sbjct: 44 IKATLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFVGTEVDPRTNSFLTWDNLQSVLKN 103
Query: 438 KICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQ 617
K+ +KG +ATP G ++LN+ LR L+LYANV SLP K R+ DVD I IRE
Sbjct: 104 KVGLKGPMATP--IGKGH-RSLNLTLRKELNLYANVRPCYSLPGYKTRYDDVDLITIREN 160
Query: 618 TEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKANIMXLGD 797
TEGEYS LEH+ V GVVE LKIIT S R+A++AF YA GRKKV+A+HKANIM D
Sbjct: 161 TEGEYSGLEHQVVKGVVESLKIITRKASMRVAEYAFLYAKTHGRKKVSAIHKANIMQKTD 220
Query: 798 GLFLR 812
GLFL+
Sbjct: 221 GLFLQ 225
>UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3;
Bacteria|Rep: Isocitrate dehydrogenase - Acidobacteria
bacterium (strain Ellin345)
Length = 348
Score = 164 bits (399), Expect = 2e-39
Identities = 87/184 (47%), Positives = 119/184 (64%), Gaps = 2/184 (1%)
Frame = +3
Query: 267 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFF-SEVNPTLSAPLEDVVN-SIAVNK 440
K TLIPGDG+GPE+ A V +A + ++ESF +E + +N SI +
Sbjct: 4 KITLIPGDGIGPEVTSAAVRVLEATGLKFEWESFAAGAEAYEKYKEYIPKELNESIERTR 63
Query: 441 ICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQT 620
I +KG + TP G ++N++LR +LYANV +++LP V R+ VD +++RE T
Sbjct: 64 IGLKGPVTTPI---GGGFSSINVELRKRFELYANVRPIRNLPGVHTRYPGVDLVVVRENT 120
Query: 621 EGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKANIMXLGDG 800
EG YS +EHE VPGVVE LKIIT S RI+KFAF+YA MGRKK+ ++HKANIM + DG
Sbjct: 121 EGLYSGIEHEVVPGVVESLKIITEKASTRISKFAFNYARKMGRKKIHSIHKANIMKMSDG 180
Query: 801 LFLR 812
LF+R
Sbjct: 181 LFIR 184
>UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=31; cellular
organisms|Rep: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 369
Score = 153 bits (371), Expect = 5e-36
Identities = 80/186 (43%), Positives = 119/186 (63%), Gaps = 2/186 (1%)
Frame = +3
Query: 258 GRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSE--VNPTLSAPLEDVVNSIA 431
G+ + I GDG+GPE+ +V+++F AA++P+++ES S VN + P + V SI
Sbjct: 35 GKYTVSFIEGDGIGPEISKSVKKIFSAANVPIEWESCDVSPIFVNGLTTIP-DPAVQSIT 93
Query: 432 VNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIR 611
N + +KG LATP G ++LN+ LR L+ANV KS+ K +++VD ++IR
Sbjct: 94 KNLVALKGPLATP--IGKGH-RSLNLTLRKTFGLFANVRPAKSIEGFKTTYENVDLVLIR 150
Query: 612 EQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKANIMXL 791
E TEGEYS +EH PGVV+ +K+IT SER+ ++AF+YA +GR +V VHK+ I L
Sbjct: 151 ENTEGEYSGIEHIVCPGVVQSIKLITRDASERVIRYAFEYARAIGRPRVIVVHKSTIQRL 210
Query: 792 GDGLFL 809
DGLF+
Sbjct: 211 ADGLFV 216
>UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8; n=1; Pan
troglodytes|Rep: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8 - Pan troglodytes
Length = 331
Score = 152 bits (369), Expect = 9e-36
Identities = 76/140 (54%), Positives = 99/140 (70%), Gaps = 1/140 (0%)
Frame = +3
Query: 255 EGRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEV-NPTLSAPLEDVVNSIA 431
EG T++PGDGVGPEL++AV+EVFKAA++PV+F+ SEV N LE V++S+
Sbjct: 46 EGSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMK 105
Query: 432 VNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIR 611
NK+ I G + TP + GEL + +M+LR LDL+ANVVHVKSLP RH ++D +IIR
Sbjct: 106 ENKVAIIGKIHTP-MEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIR 164
Query: 612 EQTEGEYSALEHESVPGVVE 671
EQTEGEYS+LEHE V E
Sbjct: 165 EQTEGEYSSLEHECCEEVAE 184
>UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH); n=6;
Eukaryota|Rep: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Caenorhabditis elegans
Length = 358
Score = 152 bits (368), Expect = 1e-35
Identities = 84/184 (45%), Positives = 114/184 (61%), Gaps = 3/184 (1%)
Frame = +3
Query: 267 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEV---NPTLSAPLEDVVNSIAVN 437
+ TLIPGDG+GPE+ +VQ++F+AA P+ ++ + V + P + + N
Sbjct: 26 RVTLIPGDGIGPEISASVQKIFEAADAPIAWDPVDVTPVKGRDGVFRIPSR-CIELMHAN 84
Query: 438 KICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQ 617
K+ +KG L TP G ++LN+ +R LYANV +SL K + +VD + IRE
Sbjct: 85 KVGLKGPLETP--IGKGH-RSLNLAVRKEFSLYANVRPCRSLEGHKTLYDNVDVVTIREN 141
Query: 618 TEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKANIMXLGD 797
TEGEYS +EHE VPGVV+ +K+IT S +A FAF+YA GRK VTAVHKANIM D
Sbjct: 142 TEGEYSGIEHEIVPGVVQSIKLITETASRNVASFAFEYARQNGRKVVTAVHKANIMRQSD 201
Query: 798 GLFL 809
GLFL
Sbjct: 202 GLFL 205
>UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=62;
Eukaryota|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Homo sapiens
(Human)
Length = 366
Score = 146 bits (355), Expect = 4e-34
Identities = 82/182 (45%), Positives = 112/182 (61%), Gaps = 2/182 (1%)
Frame = +3
Query: 273 TLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPL--EDVVNSIAVNKIC 446
TLIPGDG+GPE+ AV ++F AA P+ +E + + + + S+ NK+
Sbjct: 35 TLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPSEAKESMDKNKMG 94
Query: 447 IKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQTEG 626
+KG L TP + G ++N+ LR DLYANV S+ K + DV+ + IRE TEG
Sbjct: 95 LKGPLKTPIAA--GH-PSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENTEG 151
Query: 627 EYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKANIMXLGDGLF 806
EYS +EH V GVV+ +K+IT S+RIA+FAF+YA R VTAVHKANIM + DGLF
Sbjct: 152 EYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLF 211
Query: 807 LR 812
L+
Sbjct: 212 LQ 213
>UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421,
highly similar to PROTEIN KINASE C-BINDING PROTEIN
NELL1; n=2; Homo sapiens|Rep: CDNA FLJ36019 fis, clone
TESTI2016421, highly similar to PROTEIN KINASE C-BINDING
PROTEIN NELL1 - Homo sapiens (Human)
Length = 355
Score = 129 bits (312), Expect = 7e-29
Identities = 63/100 (63%), Positives = 76/100 (76%)
Frame = +3
Query: 513 LRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQTEGEYSALEHESVPGVVECLKIITA 692
L LDLYA+V+H+K+LPNV+ H+DVD +++ E TEGEYS LEHESV GV E LKI+T
Sbjct: 2 LHTTLDLYASVIHLKNLPNVETWHKDVDILVVWENTEGEYSNLEHESVKGVTESLKIMTK 61
Query: 693 AKSERIAKFAFDYAVXMGRKKVTAVHKANIMXLGDGLFLR 812
AKS RIA++AF A MG KKV AVHK NI LGDG FL+
Sbjct: 62 AKSLRIAEYAFQLAQKMGCKKVMAVHKVNITKLGDGPFLQ 101
>UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase family protein; n=9; Bacteria|Rep:
Isopropylmalate/isohomocitrate dehydrogenase family
protein - Synechococcus sp. (strain JA-3-3Ab)
(Cyanobacteria bacteriumYellowstone A-Prime)
Length = 368
Score = 124 bits (298), Expect = 4e-27
Identities = 82/204 (40%), Positives = 113/204 (55%), Gaps = 22/204 (10%)
Frame = +3
Query: 267 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFS-EVNPTLSAPLE-DVVNSIAVNK 440
+ TLIPGDG+GPE+ A+ V +A+ + +++ EV PL V+ SI +
Sbjct: 4 RVTLIPGDGIGPEVTRAMTTVLEASGVDLEWIRVEAGVEVIEKYGTPLPPQVLESIRETR 63
Query: 441 ICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQT 620
+ IKG + TP TG +++N+ +R LDLYAN+ KSLP +K QD+D +++RE T
Sbjct: 64 VAIKGPIGTP--VGTG-FRSVNVAIRKELDLYANLRPAKSLPGIKSPFQDIDLVVVRENT 120
Query: 621 EGEYSALEHE-SVP-------------------GVVECLKIITAAKSERIAKFAFDYAVX 740
E Y+ +E E P G +K I+ S RI KFAF+YA
Sbjct: 121 EDLYAGIEFERGTPEAAHAREEMMRLSGKFIREGSAIGIKPISEFGSRRIVKFAFEYARQ 180
Query: 741 MGRKKVTAVHKANIMXLGDGLFLR 812
GRKKVTAVHKANIM DGLFL+
Sbjct: 181 NGRKKVTAVHKANIMKFTDGLFLQ 204
>UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=5; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) - Thermus
thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Length = 496
Score = 118 bits (284), Expect = 2e-25
Identities = 70/192 (36%), Positives = 109/192 (56%), Gaps = 5/192 (2%)
Frame = +3
Query: 252 KEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFE--SFFFSEVNPTLSAPL-EDVVN 422
++GR T+IPGDG+GPE V A +V +AA P+ +E S +++ + ++ +
Sbjct: 16 EDGRKLITVIPGDGIGPECVEATLKVLEAAKAPLAYEVREAGASVFRRGIASGVPQETIE 75
Query: 423 SIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRH--QDVD 596
SI ++ +KG L TP GE ++ N+ LR + YANV V+ PNV + + +D
Sbjct: 76 SIRKTRVVLKGPLETP--VGYGE-KSANVTLRKLFETYANVRPVREFPNVPTPYAGRGID 132
Query: 597 CIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKA 776
+++RE E Y+ +EH P V + LK+I+ SE+I +FAF+ A GRKKV K+
Sbjct: 133 LVVVRENVEDLYAGIEHMQTPSVAQTLKLISWKGSEKIVRFAFELARAEGRKKVHCATKS 192
Query: 777 NIMXLGDGLFLR 812
NIM L +G R
Sbjct: 193 NIMKLAEGTLKR 204
>UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2;
Bacteria|Rep: Isocitrate dehydrogenase - Gloeobacter
violaceus
Length = 359
Score = 116 bits (280), Expect = 5e-25
Identities = 80/205 (39%), Positives = 114/205 (55%), Gaps = 24/205 (11%)
Frame = +3
Query: 267 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFF---SEVNPTLSAPLE-DVVNSIAV 434
+ TLI GDG+GPE+ A + V A I DFE +EV PL V+ ++
Sbjct: 5 RVTLIRGDGIGPEVTQAARIVLDATGI--DFEWVVVDAGAEVMEKSGTPLPAPVIEAVRA 62
Query: 435 NKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIRE 614
+ IKG + TP S ++++N+ LR ALDLYAN+ ++LP V R+ ++D +++RE
Sbjct: 63 SDAAIKGPITTPAGSG---IRSVNVALRRALDLYANLRPARTLPGVHSRYDNIDLVVVRE 119
Query: 615 QTEGEYSALEHE-SVPGVVE-------------------CLKIITAAKSERIAKFAFDYA 734
TE YS +E E + P +E +K I++ SERIA+FAF+YA
Sbjct: 120 NTEDLYSGIEFEKNSPQALEVIEMLMRLGGKKIFPRSGLAVKPISSEASERIARFAFEYA 179
Query: 735 VXMGRKKVTAVHKANIMXLGDGLFL 809
R+KVTAVHKANI+ DGLFL
Sbjct: 180 RRHARRKVTAVHKANILKHTDGLFL 204
>UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep:
CG3483 protein - Drosophila melanogaster (Fruit fly)
Length = 391
Score = 115 bits (277), Expect = 1e-24
Identities = 70/181 (38%), Positives = 102/181 (56%)
Frame = +3
Query: 267 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAVNKIC 446
K TLI G+GVG EL+ AVQEV A P++++ + + E V+ S+ NK+
Sbjct: 71 KVTLINGEGVGRELMDAVQEVICAVKAPIEWDVHDEFKAKDSDDVSPE-VLKSLRANKVG 129
Query: 447 IKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQTEG 626
IKG + D H ++R +A V + + + D D +IIR+Q EG
Sbjct: 130 IKGPV---DSRHW------QRQIRKQFAQFAYVSLCSHIEGLDSPYGDFDVVIIRDQMEG 180
Query: 627 EYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKANIMXLGDGLF 806
+YS +EH VPGV++ +K+ T A + RIA+F F+YAV RK++T HKANIM + DG F
Sbjct: 181 DYSGIEHLVVPGVMQTIKVSTTAGAARIAEFVFNYAVKNKRKRITVAHKANIMRMTDGNF 240
Query: 807 L 809
L
Sbjct: 241 L 241
>UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68;
Bacteria|Rep: Isocitrate dehydrogenase -
Janthinobacterium sp. (strain Marseille) (Minibacterium
massiliensis)
Length = 349
Score = 114 bits (274), Expect = 3e-24
Identities = 74/197 (37%), Positives = 107/197 (54%), Gaps = 7/197 (3%)
Frame = +3
Query: 240 PRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPL--ED 413
P ++ + +I TLIPGDG+GPE+V V VF A P +E+ S L +
Sbjct: 2 PNSSTQQQIPVTLIPGDGIGPEIVDVVVRVFDALGNPFAWETQQAGVNALEKSGDLLPQT 61
Query: 414 VVNSIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDV 593
++SI + +KG L+TP G +++N++LR LYANV +++ R++ +
Sbjct: 62 TLDSIGRTGLALKGPLSTPI---GGGFRSVNVRLRETFQLYANVRPARTIVPGG-RYEKI 117
Query: 594 DCIIIREQTEGEYSALEH-----ESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKV 758
D +++RE EG Y EH + V I T A S RI+KFAFDYAV R+KV
Sbjct: 118 DLVLVRENLEGLYVGHEHYVPIGDDAHAVAMATGINTRAGSRRISKFAFDYAVRNNRRKV 177
Query: 759 TAVHKANIMXLGDGLFL 809
T VHKAN++ GLFL
Sbjct: 178 TIVHKANVLKALTGLFL 194
>UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9;
Euteleostomi|Rep: NAD+-isocitrate dehydrogenase - Homo
sapiens (Human)
Length = 133
Score = 114 bits (274), Expect = 3e-24
Identities = 57/108 (52%), Positives = 77/108 (71%), Gaps = 1/108 (0%)
Frame = +3
Query: 255 EGRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEV-NPTLSAPLEDVVNSIA 431
EG T++PGDGVGPEL++AV+EVFKAAS+PV+F+ SEV N LE V++S+
Sbjct: 14 EGAFPVTMLPGDGVGPELMHAVKEVFKAASVPVEFQEHHLSEVQNMASEEKLEQVLSSMK 73
Query: 432 VNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVK 575
NK+ I G + TP + GEL + +M+LR LDL+ANV+HVKSLP V+
Sbjct: 74 ENKVAIIGKIHTP-MEYKGELASYDMRLRRKLDLFANVIHVKSLPGVQ 120
>UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=6; Rickettsiales|Rep: Isocitrate dehydrogenase,
NADP-dependent - Orientia tsutsugamushi (strain Boryong)
(Rickettsia tsutsugamushi)
Length = 519
Score = 107 bits (258), Expect = 2e-22
Identities = 67/185 (36%), Positives = 100/185 (54%), Gaps = 4/185 (2%)
Frame = +3
Query: 264 IKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSE--VNPTLSAPL-EDVVNSIAV 434
I T+ GDG+GPE++ AV V K A++P+ E+ E N + + ED + I
Sbjct: 5 IPVTIAYGDGIGPEIMEAVVYVLKEAAVPLRLETIEIGEKLYNKYYTYGITEDTWSQIFR 64
Query: 435 NKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKS-LPNVKCRHQDVDCIIIR 611
K +KG + TP G ++LN+ LR L LYANV S P V ++D +IIR
Sbjct: 65 TKALLKGPVTTPQ---GGGYKSLNVTLRKTLGLYANVRPSCSYFPFVNTSAPEIDVVIIR 121
Query: 612 EQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKANIMXL 791
E E Y+ +E+ E +K+I+ + SE+I +FAF+YA+ RK ++ K NIM
Sbjct: 122 ENEEDLYAGIEYHHTADTYESVKLISRSGSEKIIRFAFEYALKNNRKTISCFSKDNIMKF 181
Query: 792 GDGLF 806
DG+F
Sbjct: 182 TDGIF 186
>UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH).; n=1;
Bos taurus|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH). - Bos Taurus
Length = 260
Score = 107 bits (256), Expect = 4e-22
Identities = 52/95 (54%), Positives = 70/95 (73%)
Frame = +3
Query: 528 DLYANVVHVKSLPNVKCRHQDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSER 707
DL ANVV +S P V+ RH+++D +++R+ TEGEYS LE ES+ VVE L+ +T AK R
Sbjct: 17 DLCANVVQFESQPRVETRHKNIDILVVRDNTEGEYSNLEDESMNRVVESLRTVTKAKCLR 76
Query: 708 IAKFAFDYAVXMGRKKVTAVHKANIMXLGDGLFLR 812
+A++AF A MG KKVTA +KANIM LGD LF++
Sbjct: 77 LAEYAFQLAHRMGCKKVTATYKANIMRLGDCLFIQ 111
>UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]
subunit-like 4 (Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4); n=1; Arabidopsis thaliana|Rep:
Putative isocitrate dehydrogenase [NAD] subunit-like 4
(Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4) - Arabidopsis thaliana
(Mouse-ear cress)
Length = 294
Score = 105 bits (253), Expect = 1e-21
Identities = 67/167 (40%), Positives = 94/167 (56%), Gaps = 2/167 (1%)
Frame = +3
Query: 315 AVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAVNKICIKGILATPDFSHTGEL 494
AV +V A PV FE++ N ++ +VV+SI NK+C+ G +
Sbjct: 15 AVHQVMDAMQAPVYFETYIIKGKN--MNHLTWEVVDSIRKNKVCLNGRVNN--------- 63
Query: 495 QTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQTEGEYSALEHESVPGVVEC 674
+L R LDL+A++V +L RH++VD ++IRE TEGEY+ EHE VPGV+E
Sbjct: 64 -SLCGGARKELDLFASLVDCFNLNGQPSRHENVDIVVIRENTEGEYAGREHEVVPGVIES 122
Query: 675 LKI-ITAAKSERIAKFAFDYAVXMGRKKVTAVH-KANIMXLGDGLFL 809
++ +T S+RIAK+AF+YA RKKVTAVH L D FL
Sbjct: 123 FQVTMTKFWSDRIAKYAFEYAHFSKRKKVTAVHNNGKYEKLADAFFL 169
>UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3;
Rickettsiales|Rep: Isocitrate dehydrogenase - Anaplasma
marginale (strain St. Maries)
Length = 488
Score = 104 bits (249), Expect = 3e-21
Identities = 69/184 (37%), Positives = 94/184 (51%), Gaps = 4/184 (2%)
Frame = +3
Query: 264 IKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSE---VNPTLSAPLEDVVNSIAV 434
+ T+ GDGVGPE++ AV + K A V E+ S SI+
Sbjct: 8 VPITVAYGDGVGPEIMEAVLFILKEARADVSIETVDIGHNQYKKEWTSGIAPSAWESISR 67
Query: 435 NKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVH-VKSLPNVKCRHQDVDCIIIR 611
++ +K TP S G ++LN+ LR L LY NV V P V +H D+D +IIR
Sbjct: 68 TRLLLKAPTMTPQGS--GH-KSLNVALRQRLGLYVNVRPCVSYFPVVGTKHPDLDVVIIR 124
Query: 612 EQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKANIMXL 791
E E YS +EH+ EC+KI T + SE+I +AF+YA RKKVT K NIM +
Sbjct: 125 ENEEDTYSGVEHKLSEDTHECVKISTRSASEKICAYAFNYARAHNRKKVTCFVKDNIMKM 184
Query: 792 GDGL 803
DG+
Sbjct: 185 TDGI 188
>UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanobacterium thermoautotrophicum
Length = 329
Score = 103 bits (247), Expect = 5e-21
Identities = 66/182 (36%), Positives = 98/182 (53%), Gaps = 1/182 (0%)
Frame = +3
Query: 264 IKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAVNKI 443
+K +IPGDG+G E++ A + ++ +D E F ++ A L+ ++ +
Sbjct: 4 MKIAVIPGDGIGVEVMEAALHILN--TLDLDLE-FIHADAG---DACLKRTGTALPEETL 57
Query: 444 CIKGILATPDFSHTGELQT-LNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQT 620
G F GE + ++LR DL+AN+ VKSLP V C + D+D +I+RE T
Sbjct: 58 EAVGEARATLFGAAGESAADVIVRLRREFDLFANLRPVKSLPGVPCLYPDLDFVIVRENT 117
Query: 621 EGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKANIMXLGDG 800
E Y E + G V +IIT S RI++FAF YA G +KVTAVHKAN++ DG
Sbjct: 118 EDLYVGDEEYTPEGAV-AKRIITRTASRRISQFAFQYAQKEGMQKVTAVHKANVLKKTDG 176
Query: 801 LF 806
+F
Sbjct: 177 IF 178
>UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanococcus jannaschii
Length = 333
Score = 103 bits (247), Expect = 5e-21
Identities = 70/186 (37%), Positives = 100/186 (53%), Gaps = 6/186 (3%)
Frame = +3
Query: 267 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFE-SFFFSEVNPTLSAPLEDVVNSIAVNKI 443
K +I GDG+G E+V A +V +A +P +F + EV L + A++
Sbjct: 3 KICVIEGDGIGKEVVPATIQVLEATGLPFEFVYAEAGDEVYKRTGKALPEETIETALD-- 60
Query: 444 CIKGILATPDFSHTGELQT-LNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQT 620
C +L F GE + +KLR+ LD YAN+ VK+ VKC D+D +I+RE T
Sbjct: 61 C-DAVL----FGAAGETAADVIVKLRHILDTYANIRPVKAYKGVKCLRPDIDYVIVRENT 115
Query: 621 EGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYA---VXMGRK-KVTAVHKANIMX 788
EG Y +E E G+ ++IT ERI +FAF+ A MG++ KVT HKAN++
Sbjct: 116 EGLYKGIEAEIDEGITIATRVITEKACERIFRFAFNLARERKKMGKEGKVTCAHKANVLK 175
Query: 789 LGDGLF 806
L DGLF
Sbjct: 176 LTDGLF 181
>UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma;
n=1; Danio rerio|Rep: Isocitrate dehydrogenase 3 (NAD+)
gamma - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 289
Score = 101 bits (243), Expect = 2e-20
Identities = 59/150 (39%), Positives = 93/150 (62%)
Frame = +3
Query: 234 LQPRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLED 413
+ P A GR TLIPGDG+GPEL+ V+E+F+ + +PVDFE + + T + +
Sbjct: 41 IPPPAKYGGRHTVTLIPGDGIGPELLNHVRELFRFSCVPVDFEVVHVNS-SSTSEDDISN 99
Query: 414 VVNSIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDV 593
+ +I N + +KG + T + + ++ N LR +LDLYANV+H +SLP V+ RH+++
Sbjct: 100 AIMAIRRNGVALKGNIET-NHTMPPNHKSRNNLLRTSLDLYANVMHCQSLPGVQTRHKNI 158
Query: 594 DCIIIREQTEGEYSALEHESVPGVVECLKI 683
D III E++ E+SAL E+ VE L++
Sbjct: 159 DIIIILEKS--EFSALLAENEKIKVELLQL 186
>UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Thermoprotei|Rep: 3-isopropylmalate dehydrogenase -
Sulfolobus tokodaii
Length = 337
Score = 99.5 bits (237), Expect = 9e-20
Identities = 63/181 (34%), Positives = 95/181 (52%), Gaps = 4/181 (2%)
Frame = +3
Query: 276 LIPGDGVGPELVYAVQEVF----KAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAVNKI 443
LI GDG+GPE+V + + + S+P+++ E A + + ++ I
Sbjct: 7 LIQGDGIGPEIVSKSKRILAKINELYSLPIEYIEV---EAGDRALARYGEALPKDSLKII 63
Query: 444 CIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQTE 623
I+ + + +KLR D+YAN+ KS+P + ++ +VD +I+RE TE
Sbjct: 64 DKADIILKGPVGESAA--DVVVKLRQIYDMYANIRPAKSIPGIDTKYGNVDILIVRENTE 121
Query: 624 GEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKANIMXLGDGL 803
Y EH GV +KIIT SERIAK ++A+ RKKVT VHKAN+M + DGL
Sbjct: 122 DLYKGFEHIVSDGVAVGMKIITRFASERIAKVGLNFALRR-RKKVTCVHKANVMRITDGL 180
Query: 804 F 806
F
Sbjct: 181 F 181
>UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
- Archaeoglobus fulgidus
Length = 326
Score = 95.9 bits (228), Expect = 1e-18
Identities = 60/181 (33%), Positives = 95/181 (52%), Gaps = 1/181 (0%)
Frame = +3
Query: 267 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAVNKIC 446
K +IPGDG+G E++ A + + +P FE ++ + L + + + + C
Sbjct: 3 KIVVIPGDGIGKEVMEAAMLILEKLDLP--FEYSYYDAGDEALEKYGKALPDETL--EAC 58
Query: 447 IKGILATPDFSHTGELQT-LNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQTE 623
K F GE + ++LR L +ANV K++ ++C + +D +++RE TE
Sbjct: 59 RKSDAVL--FGAAGETAADVIVRLRRELGTFANVRPAKAIEGIECLYPGLDIVVVRENTE 116
Query: 624 GEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKANIMXLGDGL 803
Y E V E +++IT SERIA++AF+ A GRKKVTA+HKAN+M GL
Sbjct: 117 CLYMGFEF-GFGDVTEAIRVITREASERIARYAFELAKREGRKKVTALHKANVMKKTCGL 175
Query: 804 F 806
F
Sbjct: 176 F 176
>UniRef50_Q4UKR1 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=29; cellular organisms|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Rickettsia felis (Rickettsia azadi)
Length = 483
Score = 95.5 bits (227), Expect = 1e-18
Identities = 60/182 (32%), Positives = 92/182 (50%), Gaps = 4/182 (2%)
Frame = +3
Query: 273 TLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEV---NPTLSAPLEDVVNSIAVNKI 443
T+ GDG+GPE++ AV + + A + E+ E S E+ SI I
Sbjct: 8 TIAYGDGIGPEIMEAVLYILRKAEARIRLETIEVGEKLYKKHYTSGISEESWESIQRTGI 67
Query: 444 CIKGILATPDFSHTGELQTLNMKLRNALDLYANV-VHVKSLPNVKCRHQDVDCIIIREQT 620
+K + TP G ++LN+ +R L L+AN+ V P H ++ IIRE
Sbjct: 68 ILKAPITTPQ---GGGYKSLNVTIRKTLQLFANIRPSVSFHPFTMTLHPHLNLTIIRENE 124
Query: 621 EGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKANIMXLGDG 800
E Y+ +E+ + E +K+I+ E+I ++AF+YAV RKKVT + K NIM DG
Sbjct: 125 EDLYAGIEYRQTHNMYESIKLISHTGCEKIIRYAFEYAVKNNRKKVTCLSKDNIMKFSDG 184
Query: 801 LF 806
+F
Sbjct: 185 VF 186
>UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase; n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Isopropylmalate/isohomocitrate dehydrogenase -
Candidatus Nitrosopumilus maritimus SCM1
Length = 337
Score = 93.9 bits (223), Expect = 4e-18
Identities = 65/189 (34%), Positives = 100/189 (52%), Gaps = 7/189 (3%)
Frame = +3
Query: 267 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFE------SFFFSEVNPTLSAPLEDVVNSI 428
K +LI GDG+GPEL + V + +D + S + T A +D V++I
Sbjct: 3 KISLITGDGIGPELSDSAVSVLETIHDKLDLKFGITKLSAGDKALEQTGKALPDDTVSAI 62
Query: 429 AVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIII 608
+ C+K P ++ + LR LDLYAN+ KS P++ D+D +I+
Sbjct: 63 KQSDACMKA----PVGESAADVIVV---LRRMLDLYANIRPAKSYPHMPALRDDIDMVIV 115
Query: 609 REQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYA-VXMGRKKVTAVHKANIM 785
RE TE Y+ E S+ L+II+ S+RIAK+AF+ A + +KKVT VHK+N+M
Sbjct: 116 RENTEDLYTGKEF-SLGDSSVALRIISEQASKRIAKYAFETAKMRNDKKKVTCVHKSNVM 174
Query: 786 XLGDGLFLR 812
+ DG+F +
Sbjct: 175 RVTDGMFAK 183
>UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenase
family protein; n=6; Archaea|Rep:
Isocitrate/isopropylmalate dehydrogenase family protein
- Methanosarcina acetivorans
Length = 342
Score = 93.1 bits (221), Expect = 8e-18
Identities = 62/183 (33%), Positives = 93/183 (50%), Gaps = 5/183 (2%)
Frame = +3
Query: 276 LIPGDGVGPELVYAVQEVFKAASIPVDFE-----SFFFSEVNPTLSAPLEDVVNSIAVNK 440
+I GDGVGPELV A+ +V AA V+F + ++ E P ++ + +
Sbjct: 7 VIKGDGVGPELVEAMLKVANAAGTDVEFVMCEAGAGWWEEHGGNSLVP-DETWQILDSSD 65
Query: 441 ICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQT 620
C KG TP G +++ + +R DLYANV +K+ PN DV+ + +RE T
Sbjct: 66 ACFKGPTTTP--GGIGSPRSVAVSIRRKYDLYANVRPIKTFPNSNAPLGDVEMVCVREGT 123
Query: 621 EGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKANIMXLGDG 800
EG Y E + V ++ IT S +IA++AF+ A G V +HK+NI+ L G
Sbjct: 124 EGLYIGEEIQLTDDVSIAIRKITRTASGKIARYAFEEAKRRGYDTVVPIHKSNILKLTCG 183
Query: 801 LFL 809
FL
Sbjct: 184 SFL 186
>UniRef50_Q2UP37 Cluster: Isocitrate/isopropylmalate dehydrogenase;
n=1; Aspergillus oryzae|Rep: Isocitrate/isopropylmalate
dehydrogenase - Aspergillus oryzae
Length = 350
Score = 89.0 bits (211), Expect = 1e-16
Identities = 60/192 (31%), Positives = 97/192 (50%), Gaps = 13/192 (6%)
Frame = +3
Query: 276 LIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTL--SAPLEDVVNSIAVNKICI 449
++ G+G+GPE+ A V +A I +++ ++ L A V+ I K CI
Sbjct: 5 VLKGNGIGPEITAATIRVIEATGIQPEWDFIPIADEAVRLYGHALPPQVIQRIKDVKFCI 64
Query: 450 KG-ILATPDFSHTGELQT---------LNMKLRNALDLYANVVHVKSLPNVKCRHQDVDC 599
K +LA QT +N +R L+L+ N ++ + RH+ +D
Sbjct: 65 KAPLLAEKLHGRISCTQTDGSVVTYPSINNAIRRELNLFVNPRPIRGYVGISGRHEKMDM 124
Query: 600 IIIREQTEGEYSALEHESVPGVV-ECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKA 776
+I+RE TE Y E G E +K +T + S +++++AF+YA GRKKV+ +HKA
Sbjct: 125 VIMREITEDTYIGWEKPLEDGAAAEAIKRVTRSASWKVSQYAFEYARKHGRKKVSCLHKA 184
Query: 777 NIMXLGDGLFLR 812
N++ DGLFLR
Sbjct: 185 NVLHETDGLFLR 196
>UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Proteobacteria|Rep: 3-isopropylmalate dehydrogenase -
Bradyrhizobium japonicum
Length = 365
Score = 78.6 bits (185), Expect = 2e-13
Identities = 62/193 (32%), Positives = 95/193 (49%), Gaps = 15/193 (7%)
Frame = +3
Query: 276 LIPGDGVGPELVYAVQEVFKAAS------IPVDFESFFFSEVNPTLSAPLEDVVNSIAVN 437
++PGDG+GPE+ A V +AAS + ++ + + + + ++++ +
Sbjct: 17 VLPGDGIGPEITTATSGVLRAASERFQLNLRLEEHAVGHASLKQFGTTVRPELLDIVRGA 76
Query: 438 KICIKGILATPDFSHT--GELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIR 611
I G AT DF GE+ + R LDLYANV ++ R D D +++R
Sbjct: 77 DGLILGPTATFDFKDEAHGEINP-SRHFRKNLDLYANVRPARTYAGRPGRLGDFDLVVVR 135
Query: 612 EQTEGEYSALEHES-------VPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVH 770
E TEG Y+ E P V L+ IT A ERIA A A+ R+ +T VH
Sbjct: 136 ENTEGFYADRNMEQGNGEMLVTPDVAISLRRITRACCERIAHAACRLAMKR-RRHLTIVH 194
Query: 771 KANIMXLGDGLFL 809
KAN++ +GDG+FL
Sbjct: 195 KANVLKIGDGMFL 207
>UniRef50_Q9RTT2 Cluster: Isocitrate dehydrogenase, putative; n=2;
Deinococcus|Rep: Isocitrate dehydrogenase, putative -
Deinococcus radiodurans
Length = 333
Score = 77.4 bits (182), Expect = 4e-13
Identities = 55/186 (29%), Positives = 92/186 (49%), Gaps = 3/186 (1%)
Frame = +3
Query: 261 RIKCTLIPGDGVGPELVYAVQEVFKAASIPVDF---ESFFFSEVNPTLSAPLEDVVNSIA 431
+ + LI GDG+G E++ A + V +AA ++ E+ + ++ S P E +++
Sbjct: 3 KYRICLIEGDGIGHEVIPAAKRVLEAAGFDAEYVHAEAGYEYFLDHGTSVP-EATYDAVE 61
Query: 432 VNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIR 611
+ G +P LR +LYANV K+ P V +++VD +I+R
Sbjct: 62 NTDATLFGAATSPSGEKPAGFFGAIRHLRQKYNLYANVRPTKTRP-VPHSYENVDLVIVR 120
Query: 612 EQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKANIMXL 791
E T+G Y E + +IT S+RI KFA D A+ K++T VHK+N++ +
Sbjct: 121 ENTQGLYVEQERRYGDTAIADT-VITREASDRIGKFAADLAMKRS-KRLTVVHKSNVLPV 178
Query: 792 GDGLFL 809
GLF+
Sbjct: 179 TQGLFM 184
>UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1;
Planctomyces maris DSM 8797|Rep: Isocitrate
dehydrogenase, putative - Planctomyces maris DSM 8797
Length = 390
Score = 76.6 bits (180), Expect = 7e-13
Identities = 67/208 (32%), Positives = 101/208 (48%), Gaps = 28/208 (13%)
Frame = +3
Query: 267 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFE-SFFFSEVNPTLSAPLEDVVNSIAVNKI 443
K TLIPGDGVGPE+ A ++ A + +D++ EV + V++SI NKI
Sbjct: 3 KVTLIPGDGVGPEIAEATRKCVDATGVKIDWDVQECGIEVIEAEGGVPDRVMDSIRANKI 62
Query: 444 CIKGILATPDFSHTGE-LQTLNMKLRNALDLYANVVHVKSLPNVKCRHQD--VDCIIIRE 614
+K + TP G+ +++N+ LR L LYA + K+ V+ D VD +++RE
Sbjct: 63 ALKAPITTP----IGKGFRSVNVFLRQELGLYACIRPCKTYKGVRTYFADSNVDLVVVRE 118
Query: 615 QTEGEYSALEHES-VPGVVECLKII----TAAK-------------------SERIAKFA 722
TE Y+ +E ++ E +K I T K + I +A
Sbjct: 119 NTEDLYAGVEFQAGQEKTAELIKKINEFATGKKINTPLDETGVSIKPMSYQGTRDICNYA 178
Query: 723 FDYAVXMGRKKVTAVHKANIMXLGDGLF 806
F YAV R+ VT++ KANIM DGL+
Sbjct: 179 FKYAVDNKRQSVTSICKANIMKFTDGLW 206
>UniRef50_Q58991 Cluster: Threo-isocitrate dehydrogenase [NAD]; n=9;
Methanococcales|Rep: Threo-isocitrate dehydrogenase
[NAD] - Methanococcus jannaschii
Length = 347
Score = 76.6 bits (180), Expect = 7e-13
Identities = 56/194 (28%), Positives = 94/194 (48%), Gaps = 12/194 (6%)
Frame = +3
Query: 264 IKCTLIPGDGVGPELV-YAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAVNK 440
+K +I GDG+G E++ A++ + + + + +A ED +
Sbjct: 2 MKVCVIEGDGIGKEVIPEAIKILNELGEFEIIKGEAGLECLKKYGNALPEDTIEKAKEAD 61
Query: 441 ICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKC----------RHQD 590
I + G + +P ++ + LR LYANV + + + ++
Sbjct: 62 IILFGAITSPKPGEVQNYKSPIITLRKMFHLYANVRPINNFGIGQLIGKIADYEFLNAKN 121
Query: 591 VDCIIIREQTEGEYSALEH-ESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAV 767
+D +IIRE TE Y E E+ + E ++IT SERI +FAF+YA+ RKKV+ +
Sbjct: 122 IDIVIIRENTEDLYVGRERLENDTAIAE--RVITRKGSERIIRFAFEYAIKNNRKKVSCI 179
Query: 768 HKANIMXLGDGLFL 809
HKAN++ + DGLFL
Sbjct: 180 HKANVLRITDGLFL 193
>UniRef50_Q8XSY8 Cluster: Probable 3-isopropylmalate dehydrogenase
oxidoreductase protein; n=1; Ralstonia solanacearum|Rep:
Probable 3-isopropylmalate dehydrogenase oxidoreductase
protein - Ralstonia solanacearum (Pseudomonas
solanacearum)
Length = 365
Score = 76.2 bits (179), Expect = 9e-13
Identities = 61/199 (30%), Positives = 100/199 (50%), Gaps = 17/199 (8%)
Frame = +3
Query: 264 IKCTLIPGDGVGPELVYAVQEVFKAAS------IPVDFESFFFSEVNPTLSAPLEDVVNS 425
++ ++P DG+GPE+V A EV ++A + D++ F+ + + ++V+
Sbjct: 1 MRILVLPCDGIGPEIVGAAMEVLRSADSVFKLDLAFDYDDVGFTSLEKYGTTLRDEVLAK 60
Query: 426 IAVNKICIKGILATPDFSHTGEL-QTLNMKLRNALDLYANVVHVKSLPNVKCRHQD---V 593
I G + D+ + + ++ R LDLYANV ++ P + ++ +
Sbjct: 61 AKTYDGVILGTQSHADYPAPDKGGRNVSAGFRIGLDLYANVRPARTRPFLTSNMREGRTM 120
Query: 594 DCIIIREQTEGEYSA-------LEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRK 752
D +I+RE TEG Y E P + L+ IT SERIA+ AF+ A+ +K
Sbjct: 121 DLVIMREATEGFYPDRNMTKGWAELMPSPDMAISLRKITRHCSERIARRAFELAMKR-KK 179
Query: 753 KVTAVHKANIMXLGDGLFL 809
KVTA+HKAN + DGLFL
Sbjct: 180 KVTAIHKANSFHMTDGLFL 198
>UniRef50_A5DIP6 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 230
Score = 76.2 bits (179), Expect = 9e-13
Identities = 55/178 (30%), Positives = 85/178 (47%)
Frame = -2
Query: 806 EQSVAQXHDVGLVDGGHLLAAHXHGVVESEFRNTLGFRCGDDLQTLHHAGNGFMFQS*VL 627
EQ+++Q HD+GLVDGG L G V+ + ++LGF G DL L+H +FQS +
Sbjct: 34 EQTISQFHDIGLVDGGDQLTVVLLGKVKCKLGDSLGFEPGHDLHRLNHTRVRLVFQSRIF 93
Query: 626 SFGLFSDDDAVHVLVPALHVGQ*LHVYHVSVKIQGITELHV*GL*LASVREVRSG*DTLD 447
+F +FSD+ V+ L L G S IQ ++ ++ + R S DT
Sbjct: 94 TFSVFSDEGKVNALQTRLDAGNVFDQDQRSKNIQFFSQRNIQRF---AGRSSWSKQDTFQ 150
Query: 446 TNLVNSDRVYDVFEWCTKCWIHFRKEKGFKVHWNAGRLENFLYSVDKLRTYTVPRNQG 273
++LV+ R + + T + R F + RLEN L + T T+ N+G
Sbjct: 151 SHLVSLQRFHSLGNPGT--LVQTRNINSFPFDGDVFRLENGLDGIGDFLTNTISWNEG 206
>UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Methanosaeta thermophila PT|Rep: Isocitrate
dehydrogenase (NAD(+)) - Methanosaeta thermophila
(strain DSM 6194 / PT) (Methanothrixthermophila (strain
DSM 6194 / PT))
Length = 375
Score = 74.9 bits (176), Expect = 2e-12
Identities = 59/189 (31%), Positives = 92/189 (48%), Gaps = 12/189 (6%)
Frame = +3
Query: 279 IPGDGVGP----ELVYAVQEVFK--AASIPVDF---ESFFFSEVNPTLSAPLEDVVNSIA 431
+ GDG+GP E + +Q + + V+F E E + A +D ++++
Sbjct: 21 VDGDGIGPYITGEAIRVLQSLLRDELERGDVEFRKIEGLSIEERARAMKALPDDALDALK 80
Query: 432 VNKICIKGILATPDFSHTG-ELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIII 608
+ +KG L TP L++ N+ +R LDL+ANV V S+P+ + +D +
Sbjct: 81 KCHVILKGPLTTPKKGDPWPNLESANVAMRRELDLFANVRPV-SIPS-----EGIDWVFF 134
Query: 609 REQTEGEY--SALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKANI 782
RE TEGEY + + K+IT SERI + AFDYA +V+ V KAN+
Sbjct: 135 RENTEGEYVLGSKGFNVTDDLAVDFKVITTQGSERIIRLAFDYARRNNINRVSVVTKANV 194
Query: 783 MXLGDGLFL 809
+ DG FL
Sbjct: 195 VKTTDGKFL 203
>UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;
n=1; Ignicoccus hospitalis KIN4/I|Rep: 3-isopropylmalate
dehydrogenase - Ignicoccus hospitalis KIN4/I
Length = 343
Score = 74.5 bits (175), Expect = 3e-12
Identities = 56/187 (29%), Positives = 88/187 (47%), Gaps = 6/187 (3%)
Frame = +3
Query: 264 IKCTLIPGDGVGPELVYAVQEVFKAASIPVDFE-SFFFSEVNPTLSAPLEDVVNSIAVNK 440
+ +I GDG+GPE+V A +V + F F E + + + +
Sbjct: 2 VTVAVIEGDGIGPEVVGATLKVLEKIRETFKLPLEFVFVEAGDRAKEKYGEALPKESYER 61
Query: 441 ICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQT 620
+ + T + ++LR LDL+AN+ K LP V ++VD II+RE
Sbjct: 62 LLRADAILKGPVGETAA--DVIVRLRRELDLFANIRPAKVLPGVPALKENVDLIIVRENI 119
Query: 621 EGEYSALEH---ESVPG--VVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKANIM 785
E Y E+ ++ G V L++ + ++ R+AK A +YA R KVT VHKAN+M
Sbjct: 120 EDLYVGAENLLPQTSLGHKVAVGLRLASERETRRVAKVAAEYAKAR-RNKVTIVHKANVM 178
Query: 786 XLGDGLF 806
+ GLF
Sbjct: 179 RVTCGLF 185
>UniRef50_Q13FQ0 Cluster: Tartrate dehydrogenase; n=3;
Proteobacteria|Rep: Tartrate dehydrogenase -
Burkholderia xenovorans (strain LB400)
Length = 364
Score = 73.7 bits (173), Expect = 5e-12
Identities = 58/186 (31%), Positives = 91/186 (48%), Gaps = 19/186 (10%)
Frame = +3
Query: 279 IPGDGVGPELVYAVQEVFKAA-----SIPVDFESF-----FFSEVNPTLSAPLEDVVNSI 428
IPGDG+G E++ A +V +A S +FE+F ++ E + A D +++I
Sbjct: 9 IPGDGIGKEVIPAGAQVLEALARTSKSFAFEFENFGWGGDYYREHGVMMPA---DGLDAI 65
Query: 429 AVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNV-----KCRHQDV 593
+ G PD L L +K+ D YANV + LP + +C+ D+
Sbjct: 66 RNKDAILFGSAGDPDIPDHITLWGLRLKICQGFDQYANVRPTRILPGIDGPLKRCKPGDL 125
Query: 594 DCIIIREQTEGEYSAL---EHESVP-GVVECLKIITAAKSERIAKFAFDYAVXMGRKKVT 761
+ +I+RE +EGEYS + H+ P + I+T A ERI +FAF A RK +T
Sbjct: 126 NWVIVRENSEGEYSGVGGRVHQGHPIEAATDVSILTRAGVERIMRFAFRLAQSRPRKLLT 185
Query: 762 AVHKAN 779
+ K+N
Sbjct: 186 VITKSN 191
>UniRef50_O29610 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=15; Archaea|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Archaeoglobus fulgidus
Length = 412
Score = 73.3 bits (172), Expect = 7e-12
Identities = 64/205 (31%), Positives = 96/205 (46%), Gaps = 31/205 (15%)
Frame = +3
Query: 285 GDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPL------EDVVNSIAVNKIC 446
GDG+G ++V A V AA+ + E +F + L +D +N+I ++
Sbjct: 35 GDGIGKDVVPAAIRVLDAAADKIGKEVVWFQVYAGEDAYKLYGNYLPDDTLNAIKEFRVA 94
Query: 447 IKGILATPDFSHTGELQTLNMKLRNALDLYAN---VVHVKSLPNVKCRHQDVDCIIIREQ 617
+KG L TP G ++LN+ +R LDLYAN V ++K +P+ + V+ +I RE
Sbjct: 95 LKGPLTTPV---GGGYRSLNVTIRQVLDLYANVRPVYYLKGVPSPIKHPEKVNFVIFREN 151
Query: 618 TEGEYSALEHESVPGVVECLKIITAAKSE----------------------RIAKFAFDY 731
TE Y+ +E G E LK+I K+E R+ + A Y
Sbjct: 152 TEDVYAGIEWPR--GSEEALKLIRFLKNEFGVTIREDSGIGIKPISEFATKRLVRMAIRY 209
Query: 732 AVXMGRKKVTAVHKANIMXLGDGLF 806
A+ RK VT VHK NIM +G F
Sbjct: 210 AIENNRKSVTLVHKGNIMKYTEGAF 234
>UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Thermoproteaceae|Rep: 3-isopropylmalate dehydrogenase -
Pyrobaculum aerophilum
Length = 290
Score = 72.9 bits (171), Expect = 9e-12
Identities = 40/98 (40%), Positives = 59/98 (60%)
Frame = +3
Query: 513 LRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQTEGEYSALEHESVPGVVECLKIITA 692
+R LYAN+ VK+LP V +++DC+ +RE E Y E++ V V LK+IT
Sbjct: 50 IRMRYTLYANIRPVKNLPGVPAV-REIDCVFVRENVEDVYVGAEYK-VGDVAIALKVITE 107
Query: 693 AKSERIAKFAFDYAVXMGRKKVTAVHKANIMXLGDGLF 806
+ R+A+ A YA M R++VT VHKAN++ + DG F
Sbjct: 108 KGTRRVARMARKYA-EMRRRRVTIVHKANVLRVVDGFF 144
>UniRef50_Q8U299 Cluster: 3-isopropylmalate dehydrogenase 2; n=3;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
2 - Pyrococcus furiosus
Length = 355
Score = 71.7 bits (168), Expect = 2e-11
Identities = 65/201 (32%), Positives = 99/201 (49%), Gaps = 18/201 (8%)
Frame = +3
Query: 264 IKCTLIPGDGVGPELVY----AVQEVFKAASIPVDFESFFFS-----EVNPTLSA-PLED 413
IK +IPGDG+G E+V ++++ + +++ DF+ + F + TL LE+
Sbjct: 2 IKIAVIPGDGIGKEVVAEGLKVLRKIEELSNVKFDFQEYPFGAEHYLKTGETLPDWALEE 61
Query: 414 VVNSIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVK----SLPNVKCR 581
+ A+ I P G L +KLR +LDLY N+ VK L +K +
Sbjct: 62 FRHFDAIYFGAIGDPRVKPGILEHGIL----LKLRFSLDLYVNLRPVKLYHPKLTPLKGK 117
Query: 582 HQDVDCIIIREQTEGEYSALE---HESVPGVVECLKII-TAAKSERIAKFAFDYAVXMGR 749
+ +D + IRE TEG Y+ + P V ++I T ER +FAF+YA GR
Sbjct: 118 EK-IDMVFIRENTEGLYAGAGGFLRKGTPHEVAIQEMINTRFGVERTIRFAFEYAKTKGR 176
Query: 750 KKVTAVHKANIMXLGDGLFLR 812
KKVT V KAN++ L+ R
Sbjct: 177 KKVTLVDKANVLTYAHDLWQR 197
>UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep: Isocitrate
dehydrogenase (NAD(+)) - Candidatus Nitrosopumilus
maritimus SCM1
Length = 343
Score = 71.7 bits (168), Expect = 2e-11
Identities = 54/186 (29%), Positives = 87/186 (46%), Gaps = 6/186 (3%)
Frame = +3
Query: 267 KCTLIPGDGVGPELVYAVQEVFKAAS-----IPVDFESFFFSEVNPTLSAPLEDVVNSIA 431
K ++ GDG+GPE+V ++ V K + I + S + + ++ + DV I
Sbjct: 4 KAAVMKGDGIGPEVVDSMLRVLKECNFQSELILCEAGSEQWDKNGRKDASYIPDVTMKIL 63
Query: 432 VNK-ICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIII 608
C KG T G +++ + LR DLYAN+ K+ + + +DC+
Sbjct: 64 EETDCCFKG--PTTTIPVPGAPRSVAVTLRQKFDLYANIRPTKTYDRLT-PDRKLDCVCF 120
Query: 609 REQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKANIMX 788
RE TEG Y+ +E + ++ IT S R+ A D+A KK+ AV K NI+
Sbjct: 121 REATEGLYTGVEAKITDDAAIAIRKITRQGSRRLIDSAVDWANKFNMKKMVAVTKRNILK 180
Query: 789 LGDGLF 806
DG+F
Sbjct: 181 QTDGIF 186
>UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;
n=4; Thermococcaceae|Rep: LeuB-2 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 346
Score = 69.7 bits (163), Expect = 8e-11
Identities = 61/182 (33%), Positives = 90/182 (49%), Gaps = 2/182 (1%)
Frame = +3
Query: 267 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFS-EVNPTLSAPL-EDVVNSIAVNK 440
+ +I GDG+GPE+V + V + + + F F EV + +P+ ED + I
Sbjct: 3 RVAVIKGDGIGPEVVDSAIRVVNSVTDRIRFYEFEGGFEVFKRIGSPISEDDLKEIRKMD 62
Query: 441 ICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQT 620
+ G TP F+ G ++L + LR LDLYAN+ + L N K + +I+RE T
Sbjct: 63 AILFGATTTP-FNVPG-YRSLIVTLRKELDLYANLRIIPDLSNGK------EIVIVRENT 114
Query: 621 EGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKANIMXLGDG 800
EG Y A + +IIT + RIAKFA + A +T VHKAN++ GD
Sbjct: 115 EGLY-ARDGIGFSDRAIDFRIITLEGARRIAKFAINLAKER-NSFITFVHKANVLK-GDR 171
Query: 801 LF 806
F
Sbjct: 172 FF 173
>UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodococcus sp. (strain RHA1)
Length = 365
Score = 68.5 bits (160), Expect = 2e-10
Identities = 63/191 (32%), Positives = 90/191 (47%), Gaps = 17/191 (8%)
Frame = +3
Query: 285 GDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSA------PLED-VVNSIAVNKI 443
GDG+G E+V A Q V AA + + + E+ L A P+ D ++++
Sbjct: 18 GDGIGHEIVPATQRVVSAAVVAAGGGAVDWVELPLGLGAIESHGTPIPDSTLSALDALDA 77
Query: 444 CIKG---ILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIRE 614
I G A P+ G L T +R DL+AN+ +SL V D+D +I+RE
Sbjct: 78 WILGPHDSAAYPE-PFRGRL-TPGGVVRKRFDLFANIRPARSLEGVASTVPDMDLVIVRE 135
Query: 615 QTEGEYS-------ALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHK 773
TEG Y+ + E P V + ++T ERIA AF A GR VT VHK
Sbjct: 136 NTEGLYADRNMFAGSGEFMPTPDVALAVGVVTRKACERIAHTAFALARTRGR-HVTIVHK 194
Query: 774 ANIMXLGDGLF 806
AN++ + GLF
Sbjct: 195 ANVLSMTTGLF 205
>UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Chloroflexi (class)|Rep: 3-isopropylmalate dehydrogenase
- Roseiflexus sp. RS-1
Length = 362
Score = 68.1 bits (159), Expect = 2e-10
Identities = 61/195 (31%), Positives = 90/195 (46%), Gaps = 18/195 (9%)
Frame = +3
Query: 276 LIPGDGVGPELVYAVQEVFKAASIPVDFESF-----FFSEVNPTLSAPLEDVVNSIAVNK 440
+IPGDG+G E++ A V +A +P FE+ F L P + + A +
Sbjct: 10 VIPGDGIGREVIPAAVAVLRATGLPFHFENADAGWECFQRQGEAL--PSATLTAARAADA 67
Query: 441 ICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHV-KSLP--NVKCRHQDVDCIIIR 611
I + G +A+P + G + ++LR LDLYAN+ V LP R + VD +++R
Sbjct: 68 I-LFGAVASPGYPVAGYRSPI-VRLRRELDLYANIRPVFDDLPENGSNPRRRKVDLVVVR 125
Query: 612 EQTEGEYSALEHESVPGVVECL-KIITAAKSERIAKFAFDYAVXMGRK---------KVT 761
E TE Y+ E G ++IT S RI + A D A +VT
Sbjct: 126 ENTEDVYAGRERVEDDGATAIAERVITRRASARIMRVACDLARARRSARNGSDAPPGRVT 185
Query: 762 AVHKANIMXLGDGLF 806
VHKAN++ GLF
Sbjct: 186 VVHKANVLRETCGLF 200
>UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2;
Alphaproteobacteria|Rep: Isopropylmalate dehydrogenase -
Oceanicola granulosus HTCC2516
Length = 363
Score = 67.3 bits (157), Expect = 4e-10
Identities = 55/198 (27%), Positives = 90/198 (45%), Gaps = 15/198 (7%)
Frame = +3
Query: 261 RIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAVNK 440
R+K ++ GD +G E+V A EV +AA+ +++V P +A LE +++
Sbjct: 5 RLKLGILNGDDIGHEIVPASVEVARAAAGKAGL-GIDWTDV-PIGAAALESHGHTMPEGT 62
Query: 441 I--------CIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVD 596
+ I G + D+ + LR DL+ANV +S P + C D+D
Sbjct: 63 METLEGLDGWILGPIGHRDYPKVPGAINPHPILRKGFDLFANVRPTRSYPGIGCLFDDID 122
Query: 597 CIIIREQTEG-------EYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKK 755
+I+RE EG + E V +++IT ++ + A D A RKK
Sbjct: 123 LVIVRENNEGFQPDRNVVAGSGEFRPTEDVTISVRVITVEGCRKVVRAALDIARSRPRKK 182
Query: 756 VTAVHKANIMXLGDGLFL 809
+T VHK + LG G+F+
Sbjct: 183 LTLVHKNTVFKLGCGMFV 200
>UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;
n=4; cellular organisms|Rep: LeuB-1 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 354
Score = 67.3 bits (157), Expect = 4e-10
Identities = 57/198 (28%), Positives = 95/198 (47%), Gaps = 14/198 (7%)
Frame = +3
Query: 261 RIKCTLIPGDGVGPELVYAVQEVFKA----ASIPVDFESF-FFSEVNPTLSAPLED-VVN 422
+++ +IPGDG+G E+V +V K + + +F+ + F +E L D +
Sbjct: 2 KLRIAVIPGDGIGKEVVAEGLKVLKKLEELSRVSFEFKEYPFGAEHYLKTGETLPDWAIE 61
Query: 423 SIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVK----SLPNVKCRHQD 590
G + P + + +K+R LDLY N+ VK L +K +++
Sbjct: 62 EFKKFDAIYFGAIGDPRVKPGILERGILLKMRFELDLYVNLRPVKLYHPRLTPLKGKNK- 120
Query: 591 VDCIIIREQTEGEYSALE---HESVPGVVECLKII-TAAKSERIAKFAFDYAVXMGRKKV 758
+D + +RE TEG Y+ + P + ++I T ER+ +FAF+YA GRKKV
Sbjct: 121 IDIVFVRENTEGLYAGAGGFLRKGTPQEIAVQEMINTRFGVERVIRFAFEYAKRSGRKKV 180
Query: 759 TAVHKANIMXLGDGLFLR 812
T V KAN++ L+ R
Sbjct: 181 TLVDKANVLTYAHDLWER 198
>UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=2; Archaea|Rep: Isocitrate dehydrogenase,
NADP-dependent - Halorubrum lacusprofundi ATCC 49239
Length = 463
Score = 67.3 bits (157), Expect = 4e-10
Identities = 66/210 (31%), Positives = 98/210 (46%), Gaps = 33/210 (15%)
Frame = +3
Query: 276 LIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAP-------LEDVVNSIAV 434
+I GDG+G ++ A Q+V AA+ S + V SA ED V++I
Sbjct: 78 IIHGDGIGTDVGPAAQKVLDAAAEATG-RSIAWMRVYAGGSARDMYDENLPEDTVSAIRD 136
Query: 435 NKICIKGILATPDFSHTGELQTLNMKLRNALDLYANV---VHVKSLPNVKCRHQDVDCII 605
+++ IKG L TP + ++LN+ LR LDLYANV ++ +P+ + +D I
Sbjct: 137 HRVAIKGPLTTPVGAG---FRSLNVALRKTLDLYANVRPTYYLDGVPSPVKNPEKMDMIT 193
Query: 606 IREQTEGEYSALEHESVPGVVE-----------------------CLKIITAAKSERIAK 716
RE TE Y+ +E E+ VE +K I+ S+R+ +
Sbjct: 194 FRENTEDVYAGIEWEAGTDEVEQVRDFLEDDMEIADVIHDGPVGIGVKPISEFGSKRLIR 253
Query: 717 FAFDYAVXMGRKKVTAVHKANIMXLGDGLF 806
A DYA+ R VT VHK NIM +G F
Sbjct: 254 EAIDYALANDRDSVTLVHKGNIMKFTEGAF 283
>UniRef50_Q4V533 Cluster: IP13250p; n=4; Drosophila
melanogaster|Rep: IP13250p - Drosophila melanogaster
(Fruit fly)
Length = 475
Score = 66.5 bits (155), Expect = 8e-10
Identities = 31/87 (35%), Positives = 49/87 (56%)
Frame = +3
Query: 507 MKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQTEGEYSALEHESVPGVVECLKII 686
+K+ N LDLY +S P KCR VD +I + G ++ LE+ V GVVE L ++
Sbjct: 132 LKICNDLDLYVFKTRTRSFPGFKCRFPGVDIQLIGQNNMGIFNELEYSPVEGVVEALSVV 191
Query: 687 TAAKSERIAKFAFDYAVXMGRKKVTAV 767
+ +++ ++AF A GRK+VT +
Sbjct: 192 SQKGNDKYLRYAFKAAAKAGRKRVTLI 218
>UniRef50_Q44471 Cluster: Probable tartrate
dehydrogenase/decarboxylase ttuC; n=66; cellular
organisms|Rep: Probable tartrate
dehydrogenase/decarboxylase ttuC - Agrobacterium vitis
(Rhizobium vitis)
Length = 364
Score = 64.5 bits (150), Expect = 3e-09
Identities = 57/195 (29%), Positives = 84/195 (43%), Gaps = 19/195 (9%)
Frame = +3
Query: 267 KCTLIPGDGVGPELVYAVQEV----------FKAASIPVDFESFFFSEVNPTLSAPLEDV 416
K IP DG+GPE++ A +V FK + D+ S ++ + + A D
Sbjct: 5 KIAAIPADGIGPEVIAAGLQVLEALEQRSGDFKIHTETFDWGSDYYKKHGVMMPA---DG 61
Query: 417 VNSIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNV-----KCR 581
++ + G + PD L L + + D YANV K LP + C
Sbjct: 62 LDKLKKFDAIFFGAVGAPDVPDHITLWGLRLPICQGFDQYANVRPTKILPGITPPLRNCG 121
Query: 582 HQDVDCIIIREQTEGEYS---ALEHESVPGVVEC-LKIITAAKSERIAKFAFDYAVXMGR 749
D+D +I+RE +EGEYS H +P V + I T RI ++AF A R
Sbjct: 122 PGDLDWVIVRENSEGEYSGHGGRAHRGLPEEVGTEVAIFTRVGVTRIMRYAFKLAQARPR 181
Query: 750 KKVTAVHKANIMXLG 794
K +T V K+N G
Sbjct: 182 KLLTVVTKSNAQRHG 196
>UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase;
n=106; Bacteria|Rep: Tartrate
dehydrogenase/decarboxylase - Pseudomonas putida
Length = 365
Score = 64.1 bits (149), Expect = 4e-09
Identities = 56/189 (29%), Positives = 89/189 (47%), Gaps = 18/189 (9%)
Frame = +3
Query: 279 IPGDGVGPELVYAVQEVFKAASIP----VDFESFFFSEVNPTLSAPL---EDVVNSIAVN 437
IPGDG+G E++ V +AA++ ++F++F ++ + L +D +
Sbjct: 11 IPGDGIGLEVLPEGIRVLEAAALKHGLALEFDTFEWASCDYYLQHGKMMPDDWAEQLKQY 70
Query: 438 KICIKGILATPDF--SHTGELQTLNMKLRNALDLYANVVHVKSLPNVKC-----RHQDVD 596
G + PD H +L +K R D Y N+ V+ P V C + D+D
Sbjct: 71 DAIYFGAVDWPDKVPDHISLWGSL-LKFRREFDQYVNIRPVRLFPGVPCALANRKVGDID 129
Query: 597 CIIIREQTEGEYSALE----HESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTA 764
+++RE TEGEYS+L + +V I T +RI K+AFD A RK VT+
Sbjct: 130 FVVVRENTEGEYSSLGGIMFENTENEIVIQESIFTRRGVDRILKYAFDLAEKRERKHVTS 189
Query: 765 VHKANIMXL 791
K+N M +
Sbjct: 190 ATKSNGMAI 198
>UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Saccharopolyspora erythraea NRRL 2338|Rep:
3-isopropylmalate dehydrogenase - Saccharopolyspora
erythraea (strain NRRL 23338)
Length = 407
Score = 63.3 bits (147), Expect = 7e-09
Identities = 61/189 (32%), Positives = 86/189 (45%), Gaps = 19/189 (10%)
Frame = +3
Query: 276 LIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSE-VNPTLSAPLEDVVNSIAVNKI--- 443
+IPGDG+GPELV + EV +AA+ D E F SE +++ + +I
Sbjct: 11 VIPGDGIGPELVRSAVEVLRAAA-GRDVELRFTSEDAGADAFRRTGSAMSAATLERIRTR 69
Query: 444 ---CIKGILATPDFSHTG--ELQTLNMKLRNALDLYANVVHVKSLPNVKC--RHQDVDCI 602
+KG + P H E L LR LD YANV + LP V R VD +
Sbjct: 70 YHGVLKGPVGLPGVRHPDGTEAGLLGGVLRGGLDTYANVRPIALLPGVDAPLRGTAVDYV 129
Query: 603 IIREQTEGEYSALEHESVPGVVECLK--IITAAKSERIAKFAFDYAVXM------GRKKV 758
I+RE TEG Y + V C ++T ER+ AF+ A G ++V
Sbjct: 130 IVRENTEGLYLS-RGRGVGNDRACADQLLMTRHGVERVVVHAFELATRRTGAPADGVRRV 188
Query: 759 TAVHKANIM 785
T V K+N++
Sbjct: 189 TCVDKSNVL 197
>UniRef50_A1SM34 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Nocardioides sp. JS614|Rep: 3-isopropylmalate
dehydrogenase - Nocardioides sp. (strain BAA-499 /
JS614)
Length = 478
Score = 62.1 bits (144), Expect = 2e-08
Identities = 57/194 (29%), Positives = 90/194 (46%), Gaps = 18/194 (9%)
Frame = +3
Query: 258 GRIKCTLIPGDGVGPELVYAVQEVFKAAS-IPVDFESFFF----------SEVNPTLSAP 404
G ++ +IPGDG+GPE+ +V + AS V FE + EV P +
Sbjct: 130 GSLRLAVIPGDGIGPEVTAEALKVLEVASPAGVKFEQTRYDLGAERYLATGEVLP--DSV 187
Query: 405 LEDVVNSIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVK--- 575
LE++ A+ + G P+ + L ++LR LD Y N+ + P V
Sbjct: 188 LEEIREHDAILLGAVGGKPNDPNLPPGILERGLLLRLRFELDHYVNLRPSRIFPGVASPL 247
Query: 576 CRHQDVDCIIIREQTEGEYS----ALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXM 743
+VD +++RE TEG Y+ AL + + + + TA ER+ + AF A
Sbjct: 248 ANPGEVDFVVVREGTEGPYTGNGGALRVGTPHEIATEVSVNTAFGVERVVRDAFARAQRR 307
Query: 744 GRKKVTAVHKANIM 785
RKK+T VHK N++
Sbjct: 308 PRKKLTLVHKTNVL 321
>UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase,
mitochondrial precursor; n=33; Dikarya|Rep:
Homoisocitrate dehydrogenase, mitochondrial precursor -
Saccharomyces cerevisiae (Baker's yeast)
Length = 371
Score = 62.1 bits (144), Expect = 2e-08
Identities = 55/193 (28%), Positives = 92/193 (47%), Gaps = 16/193 (8%)
Frame = +3
Query: 276 LIPGDGVGPELVYAVQEVFKAAS----IPVDFESFF--FSEVNPTLSAPLEDVVNSIAVN 437
LIPGDG+G E++ A ++V + + + +F + F T A ++ V +
Sbjct: 28 LIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFIDLYAGFQTFQETGKALPDETVKVLKEQ 87
Query: 438 -KICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIRE 614
+ + G + +P G + + LR + L+ANV VKS+ K + +D +I+RE
Sbjct: 88 CQGALFGAVQSPTTKVEGYSSPI-VALRREMGLFANVRPVKSVEGEK--GKPIDMVIVRE 144
Query: 615 QTEGEYSALEH---ESVPG--VVECLKIITAAKSERIAKFAFDYAV----XMGRKKVTAV 767
TE Y +E + G V + K I+ + RIA A D A+ G+ +T
Sbjct: 145 NTEDLYIKIEKTYIDKATGTRVADATKRISEIATRRIATIALDIALKRLQTRGQATLTVT 204
Query: 768 HKANIMXLGDGLF 806
HK+N++ DGLF
Sbjct: 205 HKSNVLSQSDGLF 217
>UniRef50_Q5HNL1 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=73; cellular organisms|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Staphylococcus epidermidis (strain ATCC 35984 /
RP62A)
Length = 422
Score = 62.1 bits (144), Expect = 2e-08
Identities = 61/211 (28%), Positives = 97/211 (45%), Gaps = 35/211 (16%)
Frame = +3
Query: 279 IPGDGVGPELVYAVQEVFKAA-------SIPVDFESFFFSE--VNPTLSAPLEDVVNSIA 431
I GDG+GP++ A V AA ++++ + + T ++ + +I
Sbjct: 24 IIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAYDETGEWLPQETLETIK 83
Query: 432 VNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHV---KSLPNVKCRHQDVDCI 602
I +KG L TP G +++LN+ LR LDL+ + V K +P+ R +DVD +
Sbjct: 84 EYLIAVKGPLTTPI---GGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPEDVDMV 140
Query: 603 IIREQTEGEYSALEHES----VPGVVECL-------------------KIITAAKSERIA 713
I RE TE Y+ +E + V V++ L K ++ +ER+
Sbjct: 141 IFRENTEDIYAGIEFKQGTSEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLV 200
Query: 714 KFAFDYAVXMGRKKVTAVHKANIMXLGDGLF 806
+ A YA+ RK VT VHK NIM +G F
Sbjct: 201 RAAIQYALDNNRKSVTLVHKGNIMKFTEGSF 231
>UniRef50_Q0X0C1 Cluster: Putative dehydrogenase; n=1; Streptomyces
lasaliensis|Rep: Putative dehydrogenase - Streptomyces
lasaliensis
Length = 362
Score = 61.7 bits (143), Expect = 2e-08
Identities = 47/187 (25%), Positives = 80/187 (42%), Gaps = 8/187 (4%)
Frame = +3
Query: 276 LIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTL---SAPLEDVVNSIAVNKIC 446
+IPGDG+GPE++ +V A + + + L A ++ I ++
Sbjct: 24 VIPGDGIGPEVIEPALDVLDALGLGTRTDILDHVNADTYLRTGEALTGSDLDRIRSSEAA 83
Query: 447 IKGILATPDFSHTGELQTLNMKLRNALDLYAN-----VVHVKSLPNVKCRHQDVDCIIIR 611
+ G + P T ++ + LR LDLY N + H + P + +DC+I+R
Sbjct: 84 LLGAVGDPRLGDTSYVRGVLTTLRLELDLYVNYRPARLWHDRLSPLRDPARRAIDCVIVR 143
Query: 612 EQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKANIMXL 791
E TEG YS + + G E + + + ++A R+ V V KAN +
Sbjct: 144 ENTEGLYSGIGGGARTGTPEEIAVDVDLSTRHGVSRVLEFAFSAARRSVCLVDKANAVRN 203
Query: 792 GDGLFLR 812
G L+ R
Sbjct: 204 GGQLWQR 210
>UniRef50_Q0W1Q6 Cluster: 2-isopropylmalate dehydrogenase; n=5;
Euryarchaeota|Rep: 2-isopropylmalate dehydrogenase -
Uncultured methanogenic archaeon RC-I
Length = 324
Score = 60.9 bits (141), Expect = 4e-08
Identities = 56/184 (30%), Positives = 86/184 (46%), Gaps = 3/184 (1%)
Frame = +3
Query: 264 IKCTLIPGDGVGPELVYAVQEVFKAASIPVDF---ESFFFSEVNPTLSAPLEDVVNSIAV 434
+K ++PGDG+G E+V EV K A +F E V +S D+ A
Sbjct: 1 MKIAVLPGDGIGREVVPVAHEVLKVALPDAEFLHVEVGNERYVREGVSMSPADLETVKAC 60
Query: 435 NKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIRE 614
+ + I + P + +++ + LR LDLYAN+ +S P + V+ I RE
Sbjct: 61 DCVLFGAITSPPGKPY----RSIILTLRKELDLYANIRPFRSCP---ISPRKVNFTIYRE 113
Query: 615 QTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKANIMXLG 794
+E Y +E E +++IT SERIA+ A G K+T VHK+N++
Sbjct: 114 NSEDLYMGIE-EITGDEARSVRVITRKASERIARAA---CSKPGIGKLTIVHKSNVLK-A 168
Query: 795 DGLF 806
D LF
Sbjct: 169 DELF 172
>UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1;
Entamoeba histolytica HM-1:IMSS|Rep: tartrate
dehydrogenase - Entamoeba histolytica HM-1:IMSS
Length = 370
Score = 60.5 bits (140), Expect = 5e-08
Identities = 48/185 (25%), Positives = 87/185 (47%), Gaps = 9/185 (4%)
Frame = +3
Query: 267 KCTLIPGDGVGPELVYAVQEVFKAASIPV--DFESFFFSEVNPTLSAPLEDVVNSIAVNK 440
K +IPGDG+G E++ +++F++ ++P+ D+ + T D ++ +
Sbjct: 12 KIIVIPGDGIGAEVMNEAEKMFQSLNLPIQRDYVDWGIQHYLKTGKVVPIDYIDQVKQYD 71
Query: 441 ICIKGILATP-DFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKC--RHQDVDCIIIR 611
+ G L P L+ L +++R LD + + K P + + ++D +++R
Sbjct: 72 AILLGSLGDPRTLPDYVTLEPL-IQMRQQLDQFLCLRPAKHFPGIPTPLKKCEIDVLVVR 130
Query: 612 EQTEGEYSALEHESVPGVVECLKIITAAKS----ERIAKFAFDYAVXMGRKKVTAVHKAN 779
E +EGEYS + G E I +A S ER+ ++AF+ A R VT K+N
Sbjct: 131 ENSEGEYSNIGGIFKSGTPEEFAIESAVHSRRGLERVIRYAFE-ASRKRRNHVTLATKSN 189
Query: 780 IMXLG 794
M G
Sbjct: 190 AMKFG 194
>UniRef50_Q8FPV5 Cluster: 3-isopropylmalate dehydrogenase; n=50;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Corynebacterium efficiens
Length = 340
Score = 59.3 bits (137), Expect = 1e-07
Identities = 49/193 (25%), Positives = 89/193 (46%), Gaps = 10/193 (5%)
Frame = +3
Query: 264 IKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPL--EDVVNSIAVN 437
+K +I GDG+GPE+ +V +A ++ + L ++ + + +
Sbjct: 1 MKLAVIGGDGIGPEVTDEALKVLRALRADIETTDLDLGARRYLRNGELLTDEDLALLREH 60
Query: 438 KICIKGILATPDFSHTGELQT-LNMKLRNALDLYANVVHVKSLPNVKC---RHQDVDCII 605
+ G + P G L+ L +KLR ALD + N+ K V+ ++D ++
Sbjct: 61 DAILLGAIGAPGSVPPGVLERGLLLKLRFALDHHVNLRPSKLYEGVESPLKNPGEIDFVV 120
Query: 606 IREQTEGEYS----ALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVTAVHK 773
+RE TEG Y+ A+ + + T +ER+ ++AF+ A R+ +T VHK
Sbjct: 121 VREGTEGAYTGNGGAIRVGTPHETANETSVNTRYGAERVIRYAFELAQSR-RRHLTLVHK 179
Query: 774 ANIMXLGDGLFLR 812
N++ G GL+ R
Sbjct: 180 TNVLVHGGGLWQR 192
>UniRef50_Q2Q9C5 Cluster: Isocitrate dehydrogenase 3 gamma; n=8;
Eutheria|Rep: Isocitrate dehydrogenase 3 gamma - Homo
sapiens (Human)
Length = 88
Score = 58.4 bits (135), Expect = 2e-07
Identities = 32/76 (42%), Positives = 47/76 (61%), Gaps = 3/76 (3%)
Frame = +3
Query: 234 LQPRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLED 413
+ P A GR T+IPGDG+GPEL+ V+ VF+ A +PVDFE EV+ + +A ED
Sbjct: 18 IPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFE-----EVHVSSNADEED 72
Query: 414 VVNSIAV---NKICIK 452
+ N+I N++ +K
Sbjct: 73 ICNAIMAIRRNRVALK 88
>UniRef50_A6PN62 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Victivallis vadensis ATCC BAA-548|Rep: 3-isopropylmalate
dehydrogenase - Victivallis vadensis ATCC BAA-548
Length = 369
Score = 57.6 bits (133), Expect = 3e-07
Identities = 48/171 (28%), Positives = 78/171 (45%), Gaps = 15/171 (8%)
Frame = +3
Query: 267 KCTLIPGDGVGPELVYAVQEVFKAASIPVDF--ESFFFSEVNPTLSAPLE----DVVNSI 428
K ++PGDG GPE++ +V AA F E +++ A E D +
Sbjct: 6 KIAVLPGDGTGPEVIAEAVKVLDAAGRKFGFTTEKEYYNWGGAHYLATGETLPADAKEQL 65
Query: 429 AVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKC-----RHQDV 593
A + + G + PD + + +KLR LD Y N+ VK P V+ + +D+
Sbjct: 66 ARHDAVLLGAIGHPDVKPGVLEKGILLKLRFDLDQYINLRPVKLFPGVETPLANKKPEDI 125
Query: 594 DCIIIREQTEGEYSALEHE---SVPGVVECLK-IITAAKSERIAKFAFDYA 734
D +++RE + G Y+ + P V C I T ++ +R KFAF+ A
Sbjct: 126 DYVVVRENSGGVYTGMGGNVQIDTPEEVACQNWIYTRSQVDRCLKFAFELA 176
>UniRef50_Q6L2P9 Cluster: Isocitrate dehydrogenase [NADP]; n=2;
Thermoplasmatales|Rep: Isocitrate dehydrogenase [NADP] -
Picrophilus torridus
Length = 392
Score = 57.2 bits (132), Expect = 5e-07
Identities = 53/204 (25%), Positives = 97/204 (47%), Gaps = 30/204 (14%)
Frame = +3
Query: 285 GDGVGPELVYAVQEVFKAASI----PVDFESFFFSEVNPTLSAPL--EDVVNSIAVNKIC 446
GDG+GPE++ A ++V AA+ + ++ + L E+ + +I ++
Sbjct: 24 GDGIGPEIMDATRKVVDAATAMEKKSIAWKEILLGDRAEELKGDRFPEESIKAINDYRVL 83
Query: 447 IKGILATPDFSHTGE-LQTLNMKLRNALDLYANVVHVKSLPNVKC---RHQDVDCIIIRE 614
+K L TP G+ +++N+++R LDLYAN+ VK +P ++ + V+ I RE
Sbjct: 84 LKAPLNTP----VGKGFKSINVRIRMLLDLYANIRPVKFMPGLESPLKNPEKVNLTIFRE 139
Query: 615 QT-------EGEYSALEHESVPGVVE-------------CLKIITAAKSERIAKFAFDYA 734
T E Y E + + ++ +K ++ K++RI + A YA
Sbjct: 140 NTDDLYLGYEWSYDTDEAKRIRKFLKDEFNIDISDDSGIGIKPMSRYKTQRITRLAVKYA 199
Query: 735 VXMGRKKVTAVHKANIMXLGDGLF 806
+ KK+T +HK N+M +G F
Sbjct: 200 MDNNLKKITIMHKGNVMKYTEGAF 223
>UniRef50_Q67LW7 Cluster: Tartrate dehydrogenase; n=2; Bacteria|Rep:
Tartrate dehydrogenase - Symbiobacterium thermophilum
Length = 359
Score = 56.0 bits (129), Expect = 1e-06
Identities = 54/189 (28%), Positives = 88/189 (46%), Gaps = 17/189 (8%)
Frame = +3
Query: 264 IKCTLIPGDGVGPELVYAVQEVFKAAS-----IPVDFESFFFS---EVNPTLSAPLEDVV 419
+ +IPGDG+G E V A + V AA+ I ++ F + + AP + +
Sbjct: 4 VSVAVIPGDGIGNETVRAGRRVLDAAAELDGGIKFEYTEFEWGCAYYLRHGEMAP-KGFL 62
Query: 420 NSIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNV----KCRHQ 587
N++A + G + P L L + +R + Y N+ V+ L V + R+
Sbjct: 63 NTLANFDTILLGAVGYPGVPDHVSLWGLLLPIRRGFEQYVNLRPVRILRGVVSPLRGRNP 122
Query: 588 -DVDCIIIREQTEGEYSALE---HESVP-GVVECLKIITAAKSERIAKFAFDYAVXMGRK 752
DV+ + IRE TEGEYS + H +P VV + T +ERI ++A+ A RK
Sbjct: 123 GDVNFVCIRENTEGEYSNMGGRLHAGLPHEVVVQNTVFTRVGTERIIRYAYQLAANAPRK 182
Query: 753 KVTAVHKAN 779
++ K+N
Sbjct: 183 RLCGATKSN 191
>UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2;
Bacillaceae|Rep: Tartrate dehydrogenase - Bacillus sp.
B14905
Length = 362
Score = 55.6 bits (128), Expect = 1e-06
Identities = 49/186 (26%), Positives = 80/186 (43%), Gaps = 14/186 (7%)
Frame = +3
Query: 264 IKCTLIPGDGVGPELVYAVQEVFKA-----ASIPVDFESFFFSEVNPTLSAPL--EDVVN 422
IK +IPGDG+G E++ +V K +S+ + F +S + ED +
Sbjct: 4 IKMAVIPGDGIGKEVMQEALKVVKCVQERDSSLQITTMVFPWSSDYYLAHGRMMPEDALE 63
Query: 423 SIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVK---CRHQDV 593
++ + G + + L M +R Y N +KSLP + D+
Sbjct: 64 TLQKYDAILFGAIGDARVPDDVTVWELIMPIRKNFQQYVNFRPIKSLPGISSPLAGGNDI 123
Query: 594 DCIIIREQTEGEYS----ALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKKVT 761
D +I RE EGEYS L + + I+T E+I + A +YA G+ K+T
Sbjct: 124 DFVIFRENAEGEYSDSGGRLYQQQPQEMTIQNTIMTRIGIEKIVRAACEYAQQHGKTKLT 183
Query: 762 AVHKAN 779
+ K+N
Sbjct: 184 SATKSN 189
>UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=504; root|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Helicobacter pylori (Campylobacter pylori)
Length = 425
Score = 55.6 bits (128), Expect = 1e-06
Identities = 50/173 (28%), Positives = 79/173 (45%), Gaps = 26/173 (15%)
Frame = +3
Query: 372 FSEVNPTLSAPLEDVVNSIAVNKICIKGILATPDFSHTGE-LQTLNMKLRNALDLYANVV 548
+ E++P L D + +I K+ IKG L TP GE ++LN+ LR +DLY +
Sbjct: 84 YKELSPEEQWLLPDTIEAINHYKVSIKGPLTTP----IGEGFRSLNVALRQKMDLYVCLR 139
Query: 549 HVK--SLPNVKCRHQDVDCIIIREQTEGEYSALEHESVPGVVECL--------------- 677
V+ P+ Q VD +I RE +E Y+ +E + + L
Sbjct: 140 PVRWYGSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVKKIRF 199
Query: 678 --------KIITAAKSERIAKFAFDYAVXMGRKKVTAVHKANIMXLGDGLFLR 812
K I+ +ER+ + A +YA+ + VT VHK NIM +G F++
Sbjct: 200 PESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMK 252
>UniRef50_A7GLU7 Cluster: Tartrate dehydrogenase; n=3; Bacteria|Rep:
Tartrate dehydrogenase - Bacillus cereus subsp.
cytotoxis NVH 391-98
Length = 364
Score = 55.2 bits (127), Expect = 2e-06
Identities = 49/190 (25%), Positives = 82/190 (43%), Gaps = 16/190 (8%)
Frame = +3
Query: 264 IKCTLIPGDGVGPELV---YAVQEVFKAASIPVDFESFFFS---EVNPTLSAPLEDV-VN 422
+K +I GDG+GPE++ V + S FE +F E ++D +
Sbjct: 4 LKVAVIAGDGIGPEVMDEGVKVLQTIANVSQQFKFEFTYFPWGCEFYSKHGKMMDDDGIE 63
Query: 423 SIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKC-----RHQ 587
+ G + P L L +++R + D Y N+ V L C + +
Sbjct: 64 QLKAFDAIYLGAVGFPGVPDYISLWDLLLRIRQSFDQYVNIRPVTLLKGAPCPLKDVKRE 123
Query: 588 DVDCIIIREQTEGEYSALEHESVPG----VVECLKIITAAKSERIAKFAFDYAVXMGRKK 755
D+D + IRE +EGEY+ G VV + + +ERI ++AF+ A RK
Sbjct: 124 DIDMLFIRENSEGEYAGAGDWLYKGKEHEVVLQNSVFSRKGTERIIRYAFEIA-RKERKS 182
Query: 756 VTAVHKANIM 785
+T++ K N +
Sbjct: 183 LTSISKGNAL 192
>UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for
NADP+; n=3; Alteromonadales|Rep: Isocitrate
dehydrogenase, specific for NADP+ - Alteromonadales
bacterium TW-7
Length = 422
Score = 55.2 bits (127), Expect = 2e-06
Identities = 46/161 (28%), Positives = 78/161 (48%), Gaps = 26/161 (16%)
Frame = +3
Query: 408 EDVVNSIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVK---SLPNVKC 578
++ + ++ KI IKG L TP G ++LN+ LR +DL+ N+ +K +LP+
Sbjct: 87 QETIQAVRACKIAIKGPLTTP---LGGGFRSLNVALRQEMDLFVNMRTIKGFSALPSPLK 143
Query: 579 RHQDVDCIIIREQTEGEYSALEHES--------------VPGVV------EC---LKIIT 689
+ ++R+ +E YS +E ++ GV +C +K I+
Sbjct: 144 NPFLTNITVLRDSSEDVYSGIEWQAGSIESEKMLDFLCEEMGVTRLRFSQDCGIGIKNIS 203
Query: 690 AAKSERIAKFAFDYAVXMGRKKVTAVHKANIMXLGDGLFLR 812
SER+ +FA ++A+ R VT VHK N++ DG F R
Sbjct: 204 KEGSERLTRFALNFALNNNRDSVTFVHKGNVLKFTDGAFKR 244
>UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: LeuB
protein - Bradyrhizobium japonicum
Length = 359
Score = 51.6 bits (118), Expect = 2e-05
Identities = 59/194 (30%), Positives = 93/194 (47%), Gaps = 24/194 (12%)
Frame = +3
Query: 276 LIPGDGVGPELVYAVQEVFKAASIP-----VDFES---FFFSEVNPTLSAPLED--VVNS 425
++ GDG+GPE+ A V +A VD+ + F + +A E ++
Sbjct: 9 VVHGDGIGPEVARAAVAVLQAGVQAGTLRFVDYPAGADHFLKTGDSFPAASFEGCRTADA 68
Query: 426 IAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVK---SLPNVKCRHQDVD 596
I I G++ PD + G TL ++ + LDL+ANV +K +P+ R +D
Sbjct: 69 ILHGAAGIPGVVH-PDGTEAGLDFTLTLRFK--LDLFANVRPIKLYKGVPSPLGRPGPID 125
Query: 597 CIIIREQTEGEYS-----ALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXM------ 743
+I+RE +EG Y+ AL E V V+ L + T ERI +FAF+ A
Sbjct: 126 YVIVRENSEGLYAARGAGALLREEV--AVDTL-VQTRKGVERIVRFAFELARTRNGSPKD 182
Query: 744 GRKKVTAVHKANIM 785
GR++VT KAN++
Sbjct: 183 GRRRVTCCDKANVL 196
>UniRef50_Q8DTG3 Cluster: 3-isopropylmalate dehydrogenase; n=41;
Bacilli|Rep: 3-isopropylmalate dehydrogenase -
Streptococcus mutans
Length = 344
Score = 50.0 bits (114), Expect = 7e-05
Identities = 51/188 (27%), Positives = 87/188 (46%), Gaps = 15/188 (7%)
Frame = +3
Query: 267 KCTLIPGDGVGPELVYAVQEVFKAASIPVDF----ESFFFSEVNPTLSA-PL-EDVVNSI 428
K + GDG+GPE++ A EVF A + ++F E+ F S PL +D + +
Sbjct: 3 KIVTLAGDGIGPEIMAAGLEVFDAVAQKINFDYEIEAKAFGGAGIDASGHPLPDDTLAAA 62
Query: 429 AVNKICIKGILATPDFSHTGELQTLN-MKLRNALDLYANVVHV------KSLPNVKC-RH 584
+ + +P + + +R L+L+AN+ V + L +K R
Sbjct: 63 KTADAILLAAIGSPQYDKAPVRPEQGLLAIRKELNLFANIRPVRIFDALRHLSPLKAERI 122
Query: 585 QDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGR-KKVT 761
VD +++RE T G Y +H + +A++ RI + AF A+ GR KKVT
Sbjct: 123 AGVDFVVVRELTGGIYFG-QHTLTENSACDINEYSASEIRRIMRKAF--AIARGRSKKVT 179
Query: 762 AVHKANIM 785
++ K N++
Sbjct: 180 SIDKQNVL 187
>UniRef50_P41566 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 106
Score = 41.9 bits (94), Expect(2) = 8e-05
Identities = 25/65 (38%), Positives = 35/65 (53%)
Frame = +3
Query: 234 LQPRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLED 413
+ P A G + T+ PGDG GPEL+ V +A +PVDFE EV + +A ED
Sbjct: 6 IPPSAKYGGILTVTMSPGDGDGPELMLTVXXXXXSACVPVDFE-----EVVVSSNADEED 60
Query: 414 VVNSI 428
+ S+
Sbjct: 61 IRTSL 65
Score = 27.5 bits (58), Expect(2) = 8e-05
Identities = 10/15 (66%), Positives = 13/15 (86%)
Frame = +3
Query: 513 LRNALDLYANVVHVK 557
+R +LDLYANV+H K
Sbjct: 61 IRTSLDLYANVIHCK 75
>UniRef50_Q7UTP0 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodopirellula baltica
Length = 364
Score = 48.4 bits (110), Expect = 2e-04
Identities = 46/187 (24%), Positives = 79/187 (42%), Gaps = 17/187 (9%)
Frame = +3
Query: 276 LIPGDGVGPE-------LVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAV 434
++ GDG+GPE L+ +Q +D S E + A + ++
Sbjct: 9 ILGGDGIGPEVCDQSVRLLEIMQPHLDGVEFQLDRHSVGVGEYQRSGEALPQSAYDACLA 68
Query: 435 NKICIKGILATPDFSH-TGELQTLNMKLRNALDLYANV-----VHVKSLPNVKCRHQDVD 596
+ + G + P+ + G+ + LR L LY V H P ++D
Sbjct: 69 SDAVLLGAMGLPNVRYPNGKEIAPQLDLRERLQLYGGVRPIRLYHEADTPLKGHGPGEID 128
Query: 597 CIIIREQTEGEY---SALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXM-GRKKVTA 764
+++RE TEG + A+ L+I T + SER+ + AF+ A G+K VT
Sbjct: 129 FVLVRESTEGLFYGRDAIADLEADEATNLLRI-TRSASERVCRLAFETARRRDGKKTVTL 187
Query: 765 VHKANIM 785
+ KAN++
Sbjct: 188 IDKANVL 194
>UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular
organisms|Rep: Tartrate dehydrogenase - Burkholderia
mallei (Pseudomonas mallei)
Length = 361
Score = 48.0 bits (109), Expect = 3e-04
Identities = 50/191 (26%), Positives = 85/191 (44%), Gaps = 20/191 (10%)
Frame = +3
Query: 267 KCTLIPGDGVG----PELVYAVQEVFKAASI-----PVDFESFFFSEVNPTLSAPLEDVV 419
+ +IPGDG+G PE + A+ V + + P+++ S + + + +D
Sbjct: 7 RIAVIPGDGIGVEVMPEGLRALDAVSRRFGLRFAYEPIEWASCDYYAKHGQMMP--DDWK 64
Query: 420 NSIAVNKICIKGILATPDF--SHTGELQTLNMKLRNALDLYANVVHVKSLPNVKC----- 578
++ + G + P+ H +L +K R D Y N+ + V C
Sbjct: 65 TQLSGMDALLFGAVGWPETVPDHISLWGSL-IKFRREFDQYVNLRPARLFDGVPCPLAGR 123
Query: 579 RHQDVDCIIIREQTEGEYSALEHESVPGV----VECLKIITAAKSERIAKFAFDYAVXMG 746
+ D+D +I+RE TEGEYSA+ G V + T +ER+ KFAF+ A
Sbjct: 124 KAGDIDFMIVRENTEGEYSAVGGTMFEGTEREFVVQQAVFTRHGTERVLKFAFELAQRRA 183
Query: 747 RKKVTAVHKAN 779
K++T K+N
Sbjct: 184 -KRLTVATKSN 193
>UniRef50_A0P1S6 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Rhodobacterales|Rep: 3-isopropylmalate dehydrogenase -
Stappia aggregata IAM 12614
Length = 369
Score = 48.0 bits (109), Expect = 3e-04
Identities = 53/195 (27%), Positives = 86/195 (44%), Gaps = 22/195 (11%)
Frame = +3
Query: 264 IKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNP------TLSAPLEDVVNS 425
+K LI GDG+G ++ A V + A + + E+ +ED
Sbjct: 1 MKIALIKGDGIGVDVAEAAIAVLETALKHTGEPAPRYDEIQAGAGYFKETGLDIEDGGEE 60
Query: 426 IA-VNKICIKGILATPDFSHTGELQ-TLNMKLRNALDLYANVVHVKSLPNVKCRHQD--- 590
A + G + P H + + +++LR+ LYA V VK+ PN R D
Sbjct: 61 RAGLADAIFLGAIGLPSIRHANGTEISPHLRLRDRFGLYAGVRPVKAYPNAPQRLADPRA 120
Query: 591 --VDCIIIREQTEG-EYSALEHESVPGV----VECLKIITAAKSERIAKFAFDYAVXMGR 749
+D +I+RE TEG YSA H+ V V+ + IT + ++ +FAF+ A
Sbjct: 121 AGIDLVILRESTEGLFYSAAAHKRSLVVNDDEVQDVLRITRKTTTKLHRFAFNLARKRRE 180
Query: 750 K----KVTAVHKANI 782
+ ++T V KAN+
Sbjct: 181 RGHPGRLTCVDKANV 195
>UniRef50_Q81T67 Cluster: 3-isopropylmalate dehydrogenase; n=9;
Bacillus cereus group|Rep: 3-isopropylmalate
dehydrogenase - Bacillus anthracis
Length = 354
Score = 46.4 bits (105), Expect = 9e-04
Identities = 51/190 (26%), Positives = 84/190 (44%), Gaps = 13/190 (6%)
Frame = +3
Query: 255 EGRIKCTLIPGDGVGPELVYAVQEVFKAAS------IPVDFESFFFSEVNPTLSAPLEDV 416
E RI C + GDGVGPE++ + +EV + E F ++ T +
Sbjct: 2 EKRIVC--LAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEHFGGVAIDLTGQPLPQRT 59
Query: 417 VNSIAVNKICIKGILATPDFSHTGELQTLNM-KLRNALDLYANV--VHVKS----LPNVK 575
+ + + + G + P + E + LR L ++ANV V V+S L +K
Sbjct: 60 LAACLASDAVLLGAVGGPRWDGAKERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLK 119
Query: 576 CRHQDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKK 755
+ ++D +++RE T G Y + E V + ERI AF A +KK
Sbjct: 120 -KADEIDFVVVRELTGGIYFSYPKERTDEVATDTLTYHRHEIERIVSCAFQLA-SKRKKK 177
Query: 756 VTAVHKANIM 785
VT++ KAN++
Sbjct: 178 VTSIDKANVL 187
>UniRef50_Q9CKK6 Cluster: Idp; n=2; Pasteurellaceae|Rep: Idp -
Pasteurella multocida
Length = 415
Score = 44.4 bits (100), Expect = 0.003
Identities = 43/150 (28%), Positives = 64/150 (42%), Gaps = 28/150 (18%)
Frame = +3
Query: 441 ICIKGILATPDFSHTGELQTLNMKLRNALDLY---ANVVHVKSLPNVKCRHQDVDCIIIR 611
+ IKG L TP G +++LN+ +R LDLY + + P+ + VD +I R
Sbjct: 97 VAIKGPLMTPV---GGGIRSLNVAMRQGLDLYNCLRPIRYYDGTPSPVKHPELVDMVIFR 153
Query: 612 EQTEGEYSALEHESVPGVVECLKIITAAKSE-------------------------RIAK 716
E +E Y+ +E V G E K+I + E R+ +
Sbjct: 154 ENSEDIYAGVEW--VAGSAEANKVIAFLQQEMGVKKIRFTEDCGIGIKPVSKQGTQRLVR 211
Query: 717 FAFDYAVXMGRKKVTAVHKANIMXLGDGLF 806
A Y + RK +T VHK NIM +G F
Sbjct: 212 AALQYVIDNDRKSLTLVHKGNIMKFTEGAF 241
>UniRef50_Q0W5L4 Cluster: 3-isopropylmalate dehydrogenase; n=10;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Uncultured methanogenic archaeon RC-I
Length = 380
Score = 34.3 bits (75), Expect(2) = 0.006
Identities = 37/147 (25%), Positives = 62/147 (42%), Gaps = 15/147 (10%)
Frame = +3
Query: 267 KCTLIPGDGVGPE-------LVYAVQEV--FKAASIPVDFESFFFSEVNPTLSAPLEDVV 419
K +I GDG+GPE ++ A QEV F I + F + + + T+S E +
Sbjct: 5 KVPVIAGDGIGPEVIAEGRKVIAAAQEVYNFDVEWIDMPFSADHYVKTGETIS---ESSL 61
Query: 420 NSIAVNKICIKGILATPDFSHTGELQT-LNMKLRNALDLYANVVHVKSLPNVKC-----R 581
++ + G + G L+ + + +R D Y N+ VK + V+
Sbjct: 62 KELSKYRAIFLGSIGDDRKVKPGVLEKGILLTMRFYYDQYVNLRPVKLMEGVETPLKGKT 121
Query: 582 HQDVDCIIIREQTEGEYSALEHESVPG 662
D+D ++RE TE Y + S G
Sbjct: 122 AADIDFYVVRENTEDFYVGIGGRSKKG 148
Score = 28.7 bits (61), Expect(2) = 0.006
Identities = 11/37 (29%), Positives = 25/37 (67%)
Frame = +3
Query: 675 LKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKANIM 785
L +++ ++RI +++FD A +K +++V KAN++
Sbjct: 180 LGVVSKEGAKRIIEYSFDLANSRPKKHLSSVDKANVL 216
>UniRef50_Q89RJ1 Cluster: 3-isopropylmalate dehydrogenase; n=7;
Alphaproteobacteria|Rep: 3-isopropylmalate dehydrogenase
- Bradyrhizobium japonicum
Length = 368
Score = 42.7 bits (96), Expect = 0.011
Identities = 48/187 (25%), Positives = 78/187 (41%), Gaps = 18/187 (9%)
Frame = +3
Query: 276 LIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPL-------EDVVNSIAV 434
++ GDG+GPE++ EV + D F F+E + L E +
Sbjct: 20 VLAGDGIGPEVMAPAIEVLRKIEQKSDLR-FRFTEAPAGANNYLATGKSMPERTIKLCEE 78
Query: 435 NKICIKGILATPDFSHTGELQTL-NMKLRNALDLYANVVHVKSLPNVK-----CRHQDVD 596
+ G P + + ++LR DLYA V + +P V + +D
Sbjct: 79 ADAILLGACGLPSVRYPDNTEIAPQIELRFIFDLYAGVRPARLIPGVPSPIVGADTRGID 138
Query: 597 CIIIREQTEGEYSALEHESVPGV-VECLKIITAAKSERIAKFAFDYAV-XMGRKK---VT 761
++IRE TEG ++++ V +IT SER+ +F+F A R K +T
Sbjct: 139 LVVIRESTEGLFASMGKGVVTHEDARETMVITRRTSERLFEFSFRLAARRKARGKPGMLT 198
Query: 762 AVHKANI 782
V KAN+
Sbjct: 199 CVDKANV 205
>UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=38; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Synechocystis sp. (strain PCC 6803)
Length = 475
Score = 42.3 bits (95), Expect = 0.014
Identities = 28/82 (34%), Positives = 40/82 (48%), Gaps = 3/82 (3%)
Frame = +3
Query: 408 EDVVNSIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRH- 584
ED + +I + IKG L TP G +++LN+ LR DLY V + P H
Sbjct: 86 EDTLTAIKEYGVAIKGPLTTP---VGGGIRSLNVALRQIFDLYTCVRPCRYYPGTPSPHK 142
Query: 585 --QDVDCIIIREQTEGEYSALE 644
+ +D I+ RE TE Y +E
Sbjct: 143 TPEKLDIIVYRENTEDIYLGIE 164
>UniRef50_A6G3V7 Cluster: Probable 3-isopropylmalate dehydrogenase;
n=1; Plesiocystis pacifica SIR-1|Rep: Probable
3-isopropylmalate dehydrogenase - Plesiocystis pacifica
SIR-1
Length = 368
Score = 41.9 bits (94), Expect = 0.018
Identities = 37/111 (33%), Positives = 55/111 (49%), Gaps = 21/111 (18%)
Frame = +3
Query: 516 RNALDLYANVVHVKSLPNVKCR----HQD------VDCIIIREQTEGEYSALEHESVPG- 662
R L+LYANV +K P V+ R H+ VD +IIRE TEG Y+ + PG
Sbjct: 87 RMRLNLYANVRPIKLYPGVQHRIHGGHKQIWEAGKVDMVIIRENTEGLYAPTGGKLAPGG 146
Query: 663 ---VVECLKIITAAKSERIAKFAFDY-------AVXMGRKKVTAVHKANIM 785
V ++IT E++ + AF+ A G+ +VTA+ K N++
Sbjct: 147 KADVAIDTRVITRRACEQVIRHAFELCKRRNKGAPKDGKLRVTAIIKDNVL 197
>UniRef50_Q8A6M0 Cluster: 3-isopropylmalate dehydrogenase; n=42;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
- Bacteroides thetaiotaomicron
Length = 353
Score = 41.5 bits (93), Expect = 0.024
Identities = 46/190 (24%), Positives = 84/190 (44%), Gaps = 17/190 (8%)
Frame = +3
Query: 267 KCTLIPGDGVGPELVYAVQEVFKAA----SIPVDFE-SFFFSEVNPTLSAPLEDVVNSIA 431
K ++ GDG+GPE+ +V A V +E + ++ + P + +
Sbjct: 4 KIAVLAGDGIGPEISVQGVDVMSAVCEKFGHKVSYEYAICGADAIDKVGDPFPEETYEVC 63
Query: 432 VNKICIK-GILATPDFSH--TGELQTLN--MKLRNALDLYANVVHVKSLPNVKCRH---- 584
N + + P F + T +++ + +R L L+AN+ V++ + +
Sbjct: 64 KNADAVLFSAVGDPKFDNDPTAKVRPEQGLLAMRKKLGLFANIRPVQTFKCLIHKSPLRA 123
Query: 585 ---QDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVXMGRKK 755
++ D I IRE T G Y +++ + T + ERI K AF+YA+ RK
Sbjct: 124 ELVENADFICIRELTGGMYFGEKYQDNDKAYDT-NYYTRPEIERILKVAFEYAMKR-RKH 181
Query: 756 VTAVHKANIM 785
+T V KAN++
Sbjct: 182 LTVVDKANVL 191
>UniRef50_P56471 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 90
Score = 40.7 bits (91), Expect = 0.043
Identities = 16/27 (59%), Positives = 21/27 (77%)
Frame = +3
Query: 273 TLIPGDGVGPELVYAVQEVFKAASIPV 353
TLIPGDG+GPE+ AV ++F AA P+
Sbjct: 8 TLIPGDGIGPEISAAVMKIFDAAKAPI 34
>UniRef50_Q2VF40 Cluster: Isocitrate dehydrogenase 3 gamma subunit;
n=1; Pan troglodytes|Rep: Isocitrate dehydrogenase 3
gamma subunit - Pan troglodytes (Chimpanzee)
Length = 165
Score = 39.1 bits (87), Expect = 0.13
Identities = 17/32 (53%), Positives = 22/32 (68%)
Frame = +3
Query: 240 PRATKEGRIKCTLIPGDGVGPELVYAVQEVFK 335
P A GR T+IPGDG+GPEL+ V+ VF+
Sbjct: 105 PSAKYGGRHTVTMIPGDGIGPELMLHVKSVFR 136
>UniRef50_A5URE6 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=4; Chloroflexaceae|Rep: Isocitrate dehydrogenase,
NADP-dependent - Roseiflexus sp. RS-1
Length = 453
Score = 37.9 bits (84), Expect = 0.30
Identities = 17/44 (38%), Positives = 25/44 (56%)
Frame = +3
Query: 675 LKIITAAKSERIAKFAFDYAVXMGRKKVTAVHKANIMXLGDGLF 806
+K ++ +ER+ A YA+ R+ VT VHK NIM +G F
Sbjct: 218 IKPVSRLGTERLVAAAIQYAITHRRRSVTFVHKGNIMKFTEGAF 261
>UniRef50_Q5IWY1 Cluster: Plastid 3-isopropylmalate dehydrogenase;
n=1; Prototheca wickerhamii|Rep: Plastid
3-isopropylmalate dehydrogenase - Prototheca wickerhamii
Length = 211
Score = 37.1 bits (82), Expect = 0.53
Identities = 40/142 (28%), Positives = 64/142 (45%), Gaps = 20/142 (14%)
Frame = +3
Query: 267 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEV-----------NPTLSAPLED 413
+ T++PGDG+GPE+ V +AA + ESF F+E +P A
Sbjct: 40 RVTVLPGDGIGPEITAVTLSVLEAAG-KAEGESFTFTEALIGGAAYDATGDPYPDATYRA 98
Query: 414 VVNSIAVNKICIKGIL--ATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRH- 584
+S AV I G A P S + +T ++LR++L+ +AN+ +P +
Sbjct: 99 CADSDAVLLAAIGGYKWDALPSVS---KPETGLLRLRSSLNAFANLRPATVIPELADASS 155
Query: 585 ------QDVDCIIIREQTEGEY 632
+ VD +I+RE G Y
Sbjct: 156 LKREVLEGVDLLIVRELVGGIY 177
>UniRef50_Q6L0K7 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Thermoplasmatales|Rep: 3-isopropylmalate dehydrogenase -
Picrophilus torridus
Length = 335
Score = 37.1 bits (82), Expect = 0.53
Identities = 32/135 (23%), Positives = 61/135 (45%), Gaps = 2/135 (1%)
Frame = +3
Query: 264 IKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPL--EDVVNSIAVN 437
+ LIPGDG+G E++ V + S ++F +F S + + +D + +
Sbjct: 2 VDVALIPGDGIGREIMPGVAAAISSIS-DINFVTFDISSERYIKTGIIIKDDELEELKNY 60
Query: 438 KICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQ 617
+ + G + P Q + ++LR L+LY N+ V+S + + I+RE
Sbjct: 61 RAILFGAIGDPRVRPGIMEQGVILRLRRELELYMNIRPVRSFDD------KIKITILREN 114
Query: 618 TEGEYSALEHESVPG 662
T+ Y+ + +PG
Sbjct: 115 TQDFYTDIS-GIIPG 128
>UniRef50_Q7UIE1 Cluster: 3-isopropylmalate dehydrogenase; n=4;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodopirellula baltica
Length = 359
Score = 36.7 bits (81), Expect = 0.70
Identities = 52/190 (27%), Positives = 78/190 (41%), Gaps = 20/190 (10%)
Frame = +3
Query: 276 LIPGDGVGPELV----YAVQEVFKAASIPVDFES-----FFFSEVNPTLSAPLEDVVNSI 428
L+PGDG+GPE+V + +V + DF S E L P D +
Sbjct: 7 LLPGDGIGPEIVEQARLVLVKVAERFGHTFDFSSHQIGGIAIDETGDPLPQPTIDACRNA 66
Query: 429 AVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVK---SLPNVKCRHQDV-- 593
A + G D S + +K+R L L+AN+ +K L + D+
Sbjct: 67 AAILLGAVGGPKWDDPSAKTRPEAGLLKIRKELGLFANLRPIKLFDELADASPLRADIVK 126
Query: 594 --DCIIIREQTEGEYSALEHESVPGVVE-CLKIITAAKSE--RIAKFAFDYAVXMGR-KK 755
D + RE T G Y S G E + +T + E RI + A A GR +
Sbjct: 127 GTDILFFRELTGGIYFGESGTSGSGEEETAFQSMTYSVGEVKRIVRMAAQAA--RGRSNR 184
Query: 756 VTAVHKANIM 785
+T+V KAN++
Sbjct: 185 LTSVDKANVL 194
>UniRef50_Q973N4 Cluster: Putative uncharacterized protein ST0866;
n=1; Sulfolobus tokodaii|Rep: Putative uncharacterized
protein ST0866 - Sulfolobus tokodaii
Length = 344
Score = 36.3 bits (80), Expect = 0.92
Identities = 28/111 (25%), Positives = 55/111 (49%), Gaps = 1/111 (0%)
Frame = +3
Query: 234 LQPRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLED 413
L+ A K G++K I G+ P + ++E+ ASI ++ +FF ++NP +
Sbjct: 19 LKEIAEKAGKMKFNEI-WSGIDPNYIDGIKEI---ASIAEKYDMYFFVDINPEIMRGFGA 74
Query: 414 VVNSIAVNK-ICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSL 563
+++ V K + IKG+ A F+ ++ N L ++L A++ + L
Sbjct: 75 SPSNLKVFKELKIKGLRADYGFTIDDLIKMANNNLDLVIELNASIFPLDKL 125
>UniRef50_A5ADY5 Cluster: Putative uncharacterized protein; n=6; Vitis
vinifera|Rep: Putative uncharacterized protein - Vitis
vinifera (Grape)
Length = 1303
Score = 35.9 bits (79), Expect = 1.2
Identities = 27/78 (34%), Positives = 43/78 (55%), Gaps = 1/78 (1%)
Frame = +3
Query: 423 SIAVNKIC-IKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDC 599
S+A ++I ++G+LA DFS T + L+ +A+ + AN V+ + + +H +VDC
Sbjct: 1198 SLACSEIIWLRGLLAELDFSET-DPTPLHADNTSAIQITANPVY-----HERTKHIEVDC 1251
Query: 600 IIIREQTEGEYSALEHES 653
IRE E AL H S
Sbjct: 1252 HSIREAFEARVIALPHIS 1269
>UniRef50_Q54WR2 Cluster: Putative uncharacterized protein; n=2;
cellular organisms|Rep: Putative uncharacterized protein
- Dictyostelium discoideum AX4
Length = 2667
Score = 35.9 bits (79), Expect = 1.2
Identities = 22/96 (22%), Positives = 45/96 (46%), Gaps = 7/96 (7%)
Frame = +3
Query: 390 TLSAPLEDVVNSIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANV-VHVKSLP 566
T P D+ + +K I + A+ F HT K +A+DL + + VKS P
Sbjct: 551 TTGVPKNDIFTKYSTDKTTISNLYASTSFLHTDGFIQRTSKKDHAIDLLLTLFLRVKSFP 610
Query: 567 NVKCRHQD------VDCIIIREQTEGEYSALEHESV 656
++K + ++C++ + + ++SA++ S+
Sbjct: 611 SIKLNDKSPLYSSVLNCLLHSQWSVSKHSAIKIRSI 646
>UniRef50_A0T6C0 Cluster: Putative uncharacterized protein; n=1;
Burkholderia ambifaria MC40-6|Rep: Putative
uncharacterized protein - Burkholderia ambifaria MC40-6
Length = 531
Score = 34.3 bits (75), Expect = 3.7
Identities = 20/54 (37%), Positives = 28/54 (51%)
Frame = +2
Query: 605 HQRTDRRRVLSFGT*IRSRRGGVFEDHHRSEIRAYCEIRFRLRREXGPQEGDRR 766
H+RTDRRR + + RR E+ HR + E+R RE GP+ +RR
Sbjct: 343 HRRTDRRREHARPGRLPHRRHRTAENQHRHSWHRHAELRDEYAREHGPR-AERR 395
>UniRef50_A5BJM5 Cluster: Putative uncharacterized protein; n=8; Vitis
vinifera|Rep: Putative uncharacterized protein - Vitis
vinifera (Grape)
Length = 1308
Score = 34.3 bits (75), Expect = 3.7
Identities = 26/78 (33%), Positives = 42/78 (53%), Gaps = 1/78 (1%)
Frame = +3
Query: 423 SIAVNKIC-IKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDC 599
S+A ++I ++G+LA DFS T + L+ +A+ + AN V+ + + +H +VDC
Sbjct: 1177 SLACSEIIWLRGLLAELDFSET-DPTPLHADNTSAIQITANPVY-----HERTKHIEVDC 1230
Query: 600 IIIREQTEGEYSALEHES 653
IRE E L H S
Sbjct: 1231 HSIREAFEARVITLPHIS 1248
>UniRef50_Q89XA0 Cluster: 3-isopropylmalate dehydrogenase 1; n=3;
Bacteria|Rep: 3-isopropylmalate dehydrogenase 1 -
Bradyrhizobium japonicum
Length = 379
Score = 34.3 bits (75), Expect = 3.7
Identities = 48/200 (24%), Positives = 82/200 (41%), Gaps = 21/200 (10%)
Frame = +3
Query: 249 TKEGRIKCTLIPGDGVGPELVYAVQEVFKAAS----IPVDFESFFFSEVNPTLSAPL--E 410
T I ++ G+G+GPE+ + K S PV + + + + +
Sbjct: 3 TLSNTITVAVVGGEGIGPEVTDQSHRILKWFSDRRGAPVILREAQYGLIPYLATGKVLPD 62
Query: 411 DVVNSIAVNKICIKGILATPDFSHTGELQTLN---MKLRNALDLYANVVHV-------KS 560
D V ++ + G P+ + + LR+ DLYAN+ + S
Sbjct: 63 DTVEAMEEADAILWGATGGPETTEVPPAARKAGSLLSLRSKYDLYANLRPIVANPALADS 122
Query: 561 LPNVKCRHQDVDCIIIREQTEGEYSALEH--ESVPGVVE---CLKIITAAKSERIAKFAF 725
P +DVD IIIRE T G Y E++P + T ++ R+A+ AF
Sbjct: 123 APLKAAVLKDVDFIIIRELTSGIYFGEPRGIETLPDGQRRGFNTQQYTTSQIRRVARTAF 182
Query: 726 DYAVXMGRKKVTAVHKANIM 785
+ A + +V +V KAN++
Sbjct: 183 ELA-RTRKGRVCSVDKANVL 201
>UniRef50_P56472 Cluster: Isocitrate dehydrogenase [NAD] subunit
beta, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit beta,
mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase)
(NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 103
Score = 34.3 bits (75), Expect = 3.7
Identities = 14/22 (63%), Positives = 17/22 (77%)
Frame = +3
Query: 255 EGRIKCTLIPGDGVGPELVYAV 320
EG T++PGDGVGPEL+ AV
Sbjct: 12 EGAFPVTMLPGDGVGPELMAAV 33
>UniRef50_UPI0000F215F2 Cluster: PREDICTED: hypothetical protein;
n=2; Danio rerio|Rep: PREDICTED: hypothetical protein -
Danio rerio
Length = 1132
Score = 33.9 bits (74), Expect = 4.9
Identities = 14/46 (30%), Positives = 18/46 (39%)
Frame = +2
Query: 161 TCWKGCTHKFGNNREKCMLCTIWSPATEGNKGRSYQMHLDSWGRCR 298
TC + C K N + C LC W N Y +H W C+
Sbjct: 57 TCHQNCNDKDINQKSLCQLCECWRKEIVANHNGKYGIH---WNNCK 99
>UniRef50_Q0M010 Cluster: FAD dependent oxidoreductase; n=9;
Proteobacteria|Rep: FAD dependent oxidoreductase -
Caulobacter sp. K31
Length = 371
Score = 33.9 bits (74), Expect = 4.9
Identities = 16/46 (34%), Positives = 25/46 (54%)
Frame = +3
Query: 126 RNIFRAVMQGSQHVGKGVHTSSVTTEKNVCYAPFGALQPRATKEGR 263
R + AV++G H+G+GV + + Y P G+L+ R EGR
Sbjct: 28 RGLVVAVLEGEGHIGQGVSSRNSEVIHGGLYYPTGSLKARLCVEGR 73
>UniRef50_Q9LTT4 Cluster: WD domain protein-like; n=5;
Magnoliophyta|Rep: WD domain protein-like - Arabidopsis
thaliana (Mouse-ear cress)
Length = 418
Score = 33.9 bits (74), Expect = 4.9
Identities = 17/58 (29%), Positives = 26/58 (44%), Gaps = 2/58 (3%)
Frame = -3
Query: 724 KANFAIRSDFAAVMIFKHSTTPGTDSCSKAEYSPSVC--SLMMMQSTSWCLHFTLGND 557
K +F + F +I KH PG CS+ Y + ++ + S LHFT N+
Sbjct: 170 KDDFLVAGGFQGELICKHLDRPGVSFCSRMTYDDNAITNAIEIYNKPSGALHFTASNN 227
>UniRef50_A5BSB2 Cluster: Putative uncharacterized protein; n=2;
Vitis vinifera|Rep: Putative uncharacterized protein -
Vitis vinifera (Grape)
Length = 698
Score = 33.9 bits (74), Expect = 4.9
Identities = 25/78 (32%), Positives = 41/78 (52%), Gaps = 1/78 (1%)
Frame = +3
Query: 423 SIAVNKIC-IKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDC 599
S+A ++I ++G+LA DFS T + L+ +A+ + N V+ + + +H +VDC
Sbjct: 593 SLACSEIIWLRGLLAALDFSET-DPTPLHTDNTSAIQITTNPVY-----HERTKHIEVDC 646
Query: 600 IIIREQTEGEYSALEHES 653
IRE E L H S
Sbjct: 647 YSIREAFEAHVITLPHIS 664
>UniRef50_A5E2P5 Cluster: Putative uncharacterized protein; n=1;
Lodderomyces elongisporus NRRL YB-4239|Rep: Putative
uncharacterized protein - Lodderomyces elongisporus
(Yeast) (Saccharomyces elongisporus)
Length = 964
Score = 33.9 bits (74), Expect = 4.9
Identities = 17/56 (30%), Positives = 29/56 (51%), Gaps = 3/56 (5%)
Frame = +1
Query: 97 YQIQTCPFLAGIFFELLCRDLNMLERVYTQ---VR*QQRKMYVMHHLEPCNRGQQR 255
Y I TC F + IF + + + + YT+ + + +YV+HH CN+G +R
Sbjct: 802 YVIITCSFYSCIFIGITILNGGLEDEGYTESDLLTLLKNSVYVLHHYSTCNKGAER 857
>UniRef50_Q7SG44 Cluster: Putative uncharacterized protein NCU07498.1;
n=1; Neurospora crassa|Rep: Putative uncharacterized
protein NCU07498.1 - Neurospora crassa
Length = 1269
Score = 33.1 bits (72), Expect = 8.6
Identities = 13/31 (41%), Positives = 20/31 (64%)
Frame = +1
Query: 619 PKESTQLWNMNPFPAWWSV*RSSPQRNPSVL 711
P E T + ++ F WW+ +SSPQ +PS+L
Sbjct: 994 PPEPTPISSLTTFKEWWTKIQSSPQPDPSLL 1024
>UniRef50_Q12592 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Ascomycota|Rep: 3-isopropylmalate dehydrogenase -
Candida maltosa (Yeast)
Length = 251
Score = 33.1 bits (72), Expect = 8.6
Identities = 27/102 (26%), Positives = 47/102 (46%), Gaps = 11/102 (10%)
Frame = +3
Query: 273 TLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSA--------PL-EDVVNS 425
T++PGD VG E+V +V +A ++ F + + PL +D + S
Sbjct: 9 TILPGDHVGTEIVNEAIKVLEAIEAATPYQKIHFDFKHHLIGGAAIDATGVPLPDDALES 68
Query: 426 IAVNKICIKGILATPDFSHTGELQTLN--MKLRNALDLYANV 545
+ + G + P + TG L+ +K+R L+LYAN+
Sbjct: 69 AKNSDAVLLGAVGGPKWG-TGALRPEQGLLKIRKELNLYANI 109
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 830,297,162
Number of Sequences: 1657284
Number of extensions: 18033498
Number of successful extensions: 46126
Number of sequences better than 10.0: 107
Number of HSP's better than 10.0 without gapping: 44002
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 45998
length of database: 575,637,011
effective HSP length: 99
effective length of database: 411,565,895
effective search space used: 70377768045
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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