Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fcaL-P11_F_F10
(846 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_A5A7A0 Cluster: Mevalonate kinase; n=1; Bombyx mori|Rep... 425 e-118
UniRef50_UPI00015B4200 Cluster: PREDICTED: similar to mevalonate... 104 2e-21
UniRef50_UPI0000D56452 Cluster: PREDICTED: similar to mevalonate... 99 2e-19
UniRef50_UPI0000E810F5 Cluster: PREDICTED: hypothetical protein;... 85 2e-15
UniRef50_UPI0000587FA1 Cluster: PREDICTED: similar to Mevalonate... 83 9e-15
UniRef50_Q0UWF5 Cluster: Putative uncharacterized protein; n=1; ... 83 1e-14
UniRef50_Q4WP25 Cluster: Mevalonate kinase; n=15; Pezizomycotina... 79 2e-13
UniRef50_Q6CEF6 Cluster: Yarrowia lipolytica chromosome B of str... 77 6e-13
UniRef50_A7SJK4 Cluster: Predicted protein; n=1; Nematostella ve... 75 2e-12
UniRef50_Q03426 Cluster: Mevalonate kinase; n=26; Euteleostomi|R... 73 7e-12
UniRef50_A3LQ81 Cluster: Mevalonate kinase; n=5; Saccharomycetal... 68 3e-10
UniRef50_Q7PWI8 Cluster: ENSANGP00000021364; n=2; Culicidae|Rep:... 66 1e-09
UniRef50_Q86AG7 Cluster: Similar to Rattus norvegicus (Rat). Mev... 61 4e-08
UniRef50_Q65XX9 Cluster: Putative uncharacterized protein; n=5; ... 60 9e-08
UniRef50_UPI000155619E Cluster: PREDICTED: hypothetical protein,... 57 6e-07
UniRef50_Q7K2V9 Cluster: GH04687p; n=1; Drosophila melanogaster|... 56 8e-07
UniRef50_Q756D2 Cluster: AER335Wp; n=3; Saccharomycetaceae|Rep: ... 55 3e-06
UniRef50_Q2HTL9 Cluster: Mevalonate and galactokinase; n=5; core... 54 3e-06
UniRef50_Q09780 Cluster: Putative mevalonate kinase; n=1; Schizo... 54 3e-06
UniRef50_P07277 Cluster: Mevalonate kinase; n=3; Saccharomycetal... 54 5e-06
UniRef50_UPI0000DB6B27 Cluster: PREDICTED: similar to Mevalonate... 52 1e-05
UniRef50_P46086 Cluster: Mevalonate kinase; n=8; Magnoliophyta|R... 50 6e-05
UniRef50_Q4TG59 Cluster: Chromosome undetermined SCAF3891, whole... 49 2e-04
UniRef50_A2SR97 Cluster: Mevalonate kinase; n=4; Methanomicrobia... 48 4e-04
UniRef50_Q8TT37 Cluster: Mevalonate kinase; n=5; Euryarchaeota|R... 46 0.001
UniRef50_Q50559 Cluster: Mevalonate kinase; n=2; Methanothermoba... 46 0.001
UniRef50_Q0LHN3 Cluster: Mevalonate kinase; n=2; Chloroflexi (cl... 46 0.002
UniRef50_A0B6E3 Cluster: Mevalonate kinase; n=1; Methanosaeta th... 46 0.002
UniRef50_Q9V187 Cluster: Mevalonate kinase; n=4; Thermococcaceae... 46 0.002
UniRef50_Q58487 Cluster: Mevalonate kinase; n=1; Methanocaldococ... 44 0.004
UniRef50_O27995 Cluster: Mevalonate kinase; n=1; Archaeoglobus f... 44 0.005
UniRef50_UPI000155611C Cluster: PREDICTED: hypothetical protein,... 44 0.006
UniRef50_Q9HQI6 Cluster: Mevalonate kinase; n=5; Halobacteriacea... 43 0.008
UniRef50_A1RYL2 Cluster: Mevalonate kinase; n=1; Thermofilum pen... 43 0.011
UniRef50_A5UV63 Cluster: Mevalonate kinase; n=3; Chloroflexaceae... 42 0.019
UniRef50_A2E1U7 Cluster: Mevalonate kinase family protein; n=1; ... 41 0.045
UniRef50_A7DRD8 Cluster: Mevalonate kinase; n=1; Candidatus Nitr... 41 0.045
UniRef50_UPI00015BB033 Cluster: mevalonate kinase; n=1; Ignicocc... 40 0.079
UniRef50_Q2NG06 Cluster: Putative mevalonate kinase; n=1; Methan... 40 0.079
UniRef50_A5UN66 Cluster: Mevalonate kinase; n=1; Methanobrevibac... 40 0.079
UniRef50_A3H636 Cluster: Mevalonate kinase; n=1; Caldivirga maqu... 40 0.079
UniRef50_Q74JA4 Cluster: Mevalonate kinase; n=7; Lactobacillus|R... 40 0.10
UniRef50_Q2BIK0 Cluster: Mevalonate kinase, putative; n=1; Neptu... 40 0.10
UniRef50_Q8TWN9 Cluster: Mevalonate kinase; n=1; Methanopyrus ka... 39 0.14
UniRef50_A3HYY0 Cluster: Galactokinase; n=1; Algoriphagus sp. PR... 39 0.18
UniRef50_A2BL67 Cluster: Mevalonate kinase; n=1; Hyperthermus bu... 39 0.18
UniRef50_Q9Y946 Cluster: Mevalonate kinase; n=1; Aeropyrum perni... 39 0.18
UniRef50_Q8L1I1 Cluster: Phosphomevalonate kinase; n=1; Paracocc... 38 0.24
UniRef50_A6G140 Cluster: Hydroxymethylglutaryl-CoA reductase; n=... 38 0.24
UniRef50_Q6LXL5 Cluster: Mevalonate kinase; n=5; Methanococcus|R... 38 0.24
UniRef50_Q8L1I2 Cluster: Mevalonate kinase; n=1; Paracoccus zeax... 38 0.42
UniRef50_A5EVP5 Cluster: GHMP kinase family protein; n=1; Dichel... 38 0.42
UniRef50_A5EUV5 Cluster: GHMP kinase family protein; n=1; Dichel... 38 0.42
UniRef50_Q83DT3 Cluster: Mevalonate kinase, putative; n=3; Coxie... 37 0.55
UniRef50_Q22LZ8 Cluster: ATPase, AAA family protein; n=1; Tetrah... 37 0.55
UniRef50_A0E671 Cluster: Chromosome undetermined scaffold_8, who... 37 0.55
UniRef50_Q7QVN5 Cluster: GLP_305_18405_19430; n=1; Giardia lambl... 36 0.97
UniRef50_Q4J2X7 Cluster: Putative uncharacterized protein; n=1; ... 36 1.3
UniRef50_Q03FN7 Cluster: Mevalonate kinase; n=1; Pediococcus pen... 36 1.3
UniRef50_A6G138 Cluster: Mevalonate kinase; n=1; Plesiocystis pa... 36 1.3
UniRef50_A2DPP4 Cluster: Phosphatidylinositol 3-and 4-kinase fam... 36 1.3
UniRef50_Q83DT4 Cluster: Phosphomevalonate kinase, putative; n=2... 36 1.7
UniRef50_A2U564 Cluster: Mevalonate kinase; n=1; Bacillus coagul... 36 1.7
UniRef50_Q6E6I3 Cluster: Mevalonate kinase-like protein; n=1; An... 35 2.2
UniRef50_Q9FD69 Cluster: Mevalonate kinase; n=4; Enterococcus|Re... 35 3.0
UniRef50_Q2BIJ9 Cluster: GHMP kinase; n=1; Neptuniibacter caesar... 35 3.0
UniRef50_Q2GZQ7 Cluster: Putative uncharacterized protein; n=1; ... 35 3.0
UniRef50_Q97UL6 Cluster: (Phospho) mevalonate kinase, putative; ... 35 3.0
UniRef50_Q7XJS3 Cluster: At2g17440 protein; n=3; Brassicaceae|Re... 34 3.9
UniRef50_A3DL21 Cluster: Mevalonate kinase; n=1; Staphylothermus... 34 3.9
UniRef50_Q38X71 Cluster: Mevalonate kinase; n=1; Lactobacillus s... 34 5.2
UniRef50_A6GIJ2 Cluster: Putative uncharacterized protein; n=1; ... 34 5.2
UniRef50_A5VK03 Cluster: Mevalonate kinase; n=2; Lactobacillus r... 34 5.2
UniRef50_A4VT18 Cluster: Mevalonate kinase; n=4; Streptococcus|R... 34 5.2
UniRef50_Q8F618 Cluster: Putative uncharacterized protein; n=2; ... 33 6.8
UniRef50_Q8H912 Cluster: Putative zinc knuckle domain containing... 33 6.8
UniRef50_Q60ED2 Cluster: Putative uncharacterized protein OSJNBa... 33 6.8
UniRef50_Q8SQK4 Cluster: MEVALONATE KINASE; n=1; Encephalitozoon... 33 6.8
UniRef50_UPI0000DB7B87 Cluster: PREDICTED: similar to CG5127-PA ... 33 9.0
UniRef50_Q08UJ8 Cluster: Mevalonate kinase; n=2; Cystobacterinea... 33 9.0
UniRef50_Q031R4 Cluster: Mevalonate kinase; n=3; Lactococcus lac... 33 9.0
UniRef50_Q8ZTT2 Cluster: Mevalonate kinase; n=4; Pyrobaculum|Rep... 33 9.0
>UniRef50_A5A7A0 Cluster: Mevalonate kinase; n=1; Bombyx mori|Rep:
Mevalonate kinase - Bombyx mori (Silk moth)
Length = 413
Score = 425 bits (1047), Expect = e-118
Identities = 203/203 (100%), Positives = 203/203 (100%)
Frame = +1
Query: 196 MLTAVDNLFTVSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIH 375
MLTAVDNLFTVSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIH
Sbjct: 1 MLTAVDNLFTVSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIH 60
Query: 376 LPCVDLQETIPLEPTVKSLFHPKLAPGITGKFSWRLPHKIDHDYHLRRVEEYLHLIKPNF 555
LPCVDLQETIPLEPTVKSLFHPKLAPGITGKFSWRLPHKIDHDYHLRRVEEYLHLIKPNF
Sbjct: 61 LPCVDLQETIPLEPTVKSLFHPKLAPGITGKFSWRLPHKIDHDYHLRRVEEYLHLIKPNF 120
Query: 556 DSLPNNQKNSLRSFLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGAL 735
DSLPNNQKNSLRSFLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGAL
Sbjct: 121 DSLPNNQKNSLRSFLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGAL 180
Query: 736 IQLLKLKSSSGNFDAYYDQSSQD 804
IQLLKLKSSSGNFDAYYDQSSQD
Sbjct: 181 IQLLKLKSSSGNFDAYYDQSSQD 203
Score = 35.9 bits (79), Expect = 1.3
Identities = 16/34 (47%), Positives = 20/34 (58%)
Frame = +3
Query: 744 VEIEEFFGEFRCILRSEQPRFTDTEKEIISEWAF 845
++++ G F FTDTEKEIISEWAF
Sbjct: 184 LKLKSSSGNFDAYYDQSSQDFTDTEKEIISEWAF 217
>UniRef50_UPI00015B4200 Cluster: PREDICTED: similar to mevalonate
kinase; n=1; Nasonia vitripennis|Rep: PREDICTED: similar
to mevalonate kinase - Nasonia vitripennis
Length = 388
Score = 104 bits (250), Expect = 2e-21
Identities = 65/179 (36%), Positives = 99/179 (55%), Gaps = 1/179 (0%)
Frame = +1
Query: 232 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPA-VHIHLPCVDLQETIP 408
+SAPGKVIL GEHSVVYGKTA+A SLGLRSS+ E+ PHE +HI +P + + + +
Sbjct: 6 ISAPGKVILFGEHSVVYGKTAVAASLGLRSSLHFTEL--PHEECIIHIKMPKLGISKILS 63
Query: 409 LEPTVKSLFHPKLAPGITGKFSWRLPHKIDHDYHLRRVEEYLHLIKPNFDSLPNNQKNSL 588
L + GI ++HD +++++Y+ + F++ +Q+ S+
Sbjct: 64 LHQVEEDFHRLDFYSGIA----------MNHDAINQKLQKYVATL--GFEN--PDQRLSM 109
Query: 589 RSFLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQLLKLKSSS 765
F Y + S L + S + + SEL+IGAG GSSASF VCL + +L+ +
Sbjct: 110 ECFFYAMMQVIRSDQLRLSSFILELDSELSIGAGAGSSASFTVCLVACFLHWSQLQKGT 168
>UniRef50_UPI0000D56452 Cluster: PREDICTED: similar to mevalonate
kinase; n=3; Endopterygota|Rep: PREDICTED: similar to
mevalonate kinase - Tribolium castaneum
Length = 490
Score = 98.7 bits (235), Expect = 2e-19
Identities = 70/183 (38%), Positives = 98/183 (53%), Gaps = 3/183 (1%)
Frame = +1
Query: 217 LFTVSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAV-HIHL-PCVD 390
L + VSAPGKVILHGEHSVVY K A+A SLGLR+ + E + L C +
Sbjct: 95 LSEIRVSAPGKVILHGEHSVVYDKLAVAASLGLRTRLEYCEEGAGLRVEFGDLGLTQCYN 154
Query: 391 LQETIPLEPTVKSLFHPKLAPGITGKFSWRLPHKIDHDYHLRRVEEYLHLIKPNFDSLPN 570
++ L T L P T ++ P +DHD VE+++ L +
Sbjct: 155 FKDVHQLLSTQIPLTQP------TAYYNLTHPELLDHDKITEIVEKFVDLNRHE-----P 203
Query: 571 NQKNSLRSFLYVFSGIFGSTYLPVK-SMDISMGSELTIGAGTGSSASFAVCLAGALIQLL 747
Q+ +L SF Y+F I GST + +++ S+LT+GAGTGSSASFAV +A L+ +
Sbjct: 204 KQRQALVSFFYLFFAIVGSTDSNLSDGFKLAVRSDLTVGAGTGSSASFAVAIAAFLLHFV 263
Query: 748 KLK 756
K+K
Sbjct: 264 KVK 266
>UniRef50_UPI0000E810F5 Cluster: PREDICTED: hypothetical protein;
n=1; Gallus gallus|Rep: PREDICTED: hypothetical protein
- Gallus gallus
Length = 527
Score = 85.0 bits (201), Expect = 2e-15
Identities = 68/187 (36%), Positives = 100/187 (53%), Gaps = 18/187 (9%)
Frame = +1
Query: 232 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCV------DL 393
VSAPGKVILHGEH+VV+GK A+AV+LGLR+ + ++ + IHLP V D+
Sbjct: 181 VSAPGKVILHGEHAVVHGKAALAVALGLRTFLRLRPGGGER---LRIHLPGVGVRREWDV 237
Query: 394 QETIPLEPTVKSLFHPKLAPGITGKF----SWRL----PHKIDHDYHLRRVEEYLHLIKP 549
E L + F+ K G+ + +W + + D D E L ++K
Sbjct: 238 AELSALRGRLTEWFYVKPGVGLDDPYGCFPTWGVVGFFEPEADFDESKSPGVEQLDVLK- 296
Query: 550 NFDSLPNN----QKNSLRSFLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAV 717
F + + ++ +FLY+ I + Y V S+DI++ SEL GAG GSSA++AV
Sbjct: 297 EFAGIAADASAPDSLAILAFLYMCLAI-SAKYGDVPSVDIAVWSELPTGAGLGSSAAYAV 355
Query: 718 CLAGALI 738
CLA AL+
Sbjct: 356 CLAAALL 362
>UniRef50_UPI0000587FA1 Cluster: PREDICTED: similar to Mevalonate
kinase (MK); n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to Mevalonate kinase (MK) -
Strongylocentrotus purpuratus
Length = 413
Score = 83.0 bits (196), Expect = 9e-15
Identities = 62/201 (30%), Positives = 108/201 (53%), Gaps = 4/201 (1%)
Frame = +1
Query: 223 TVSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQ-- 396
++ +SAPGK+ILHGEH+VV+GKTA+A L LRS + +KE ++ +H++LP +DL+
Sbjct: 15 SIFISAPGKIILHGEHAVVHGKTALAAGLNLRSYLCLKEKDSGR---LHLNLPDIDLERS 71
Query: 397 -ETIPLEPTVKSLFHPKLAPGITGKFSWRLPHKIDHDYHLRRVEEYLHLIKPNFDSLPNN 573
+ + L+ + L + + + K S + ++R+ +L +
Sbjct: 72 WDVLELQEQFRDLLNSDV---MEVKPSVEI---------MQRLRLFL-----GYSDTETT 114
Query: 574 QKNSLRSFLYVFSGIFG-STYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQLLK 750
++ ++ +FLY++ I G + P+ +D + S L GAG GSSA+F+VCLA L+ K
Sbjct: 115 KRLAVMAFLYLYLCIAGRNGKFPI--LDTLVSSALPPGAGLGSSAAFSVCLAAGLLTWAK 172
Query: 751 LKSSSGNFDAYYDQSSQDLRI 813
D D S +D+ +
Sbjct: 173 AIIPLSLSDNTLDWSREDMEL 193
>UniRef50_Q0UWF5 Cluster: Putative uncharacterized protein; n=1;
Phaeosphaeria nodorum|Rep: Putative uncharacterized
protein - Phaeosphaeria nodorum (Septoria nodorum)
Length = 526
Score = 82.6 bits (195), Expect = 1e-14
Identities = 62/202 (30%), Positives = 107/202 (52%), Gaps = 1/202 (0%)
Frame = +1
Query: 232 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQETIPL 411
VSAPGKVI++GEH+VV+GK AIA ++ LRS + + ++ + V + P + ++ T +
Sbjct: 37 VSAPGKVIVYGEHAVVHGKAAIAAAISLRSYLHVSFLSKSNR-TVKLRFPDIQMEHTWDI 95
Query: 412 EPTVKSLFHPKLAPGITGKFSWRLPHKIDHDYHLRRVEEYLHLIKPNF-DSLPNNQKNSL 588
+ F PG K+ + L +D D + ++ ++ + P +S+ S
Sbjct: 96 DELPWDSFS---KPG-KKKYYYDLVTSLDPDL-MAAIQPFIDEVSPKAPESVRKIHHASA 150
Query: 589 RSFLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQLLKLKSSSG 768
SFLY+F + P ++ S + IGAG GSSAS +VCL+ A+ L+++++ SG
Sbjct: 151 CSFLYLFLSLASRKTPP---CIYTLRSTIPIGAGLGSSASISVCLSAAM--LMQIRALSG 205
Query: 769 NFDAYYDQSSQDLRIPKRRLYR 834
+ DQ Q+ + R+ R
Sbjct: 206 ---PHQDQPPQECELNIERINR 224
>UniRef50_Q4WP25 Cluster: Mevalonate kinase; n=15;
Pezizomycotina|Rep: Mevalonate kinase - Aspergillus
fumigatus (Sartorya fumigata)
Length = 538
Score = 78.6 bits (185), Expect = 2e-13
Identities = 60/202 (29%), Positives = 109/202 (53%), Gaps = 1/202 (0%)
Frame = +1
Query: 232 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQETIPL 411
VSAPGKVI++GEH+VV+GK A+A ++ LRS +++ + + + + ++ + L T +
Sbjct: 94 VSAPGKVIVYGEHAVVHGKAAMAAAISLRSYLLVTTL-SKSQRTITMNFRDIGLDHTWNI 152
Query: 412 EPTVKSLFHPKLAPGITGKFSWRLPHKIDHDYHLRRVEEYLHLIKPNF-DSLPNNQKNSL 588
+ +FH P KF + L +D + + ++ + + P+ + + + S
Sbjct: 153 DELPWDVFH---HPS-KKKFYYDLVTSLDPEL-VAAIQPHADAVSPDKPEDVRKIHRRSA 207
Query: 589 RSFLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQLLKLKSSSG 768
+FLY+F + GS+ P ++ S + IGAG GSSAS VCL+ AL LL++++ +G
Sbjct: 208 SAFLYLFLSL-GSSQNP--GAIYTLRSTIPIGAGLGSSASVCVCLSAAL--LLQIRTLAG 262
Query: 769 NFDAYYDQSSQDLRIPKRRLYR 834
+ DQ + + R+ R
Sbjct: 263 ---PHPDQPPDEAEVQIERINR 281
>UniRef50_Q6CEF6 Cluster: Yarrowia lipolytica chromosome B of strain
CLIB122 of Yarrowia lipolytica; n=1; Yarrowia
lipolytica|Rep: Yarrowia lipolytica chromosome B of
strain CLIB122 of Yarrowia lipolytica - Yarrowia
lipolytica (Candida lipolytica)
Length = 449
Score = 77.0 bits (181), Expect = 6e-13
Identities = 56/171 (32%), Positives = 85/171 (49%)
Frame = +1
Query: 232 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQETIPL 411
+SAPGKVIL GEH+ V+GK AIA ++ LR+ +++ E T P V + P + L + +
Sbjct: 5 ISAPGKVILFGEHAAVFGKPAIAAAIDLRTYLLV-ETTTSDTPTVTLEFPDIHLNFKVQV 63
Query: 412 EPTVKSLFHPKLAPGITGKFSWRLPHKIDHDYHLRRVEEYLHLIKPNFDSLPNNQKNSLR 591
+ K +W P +D H+ L L++ L Q+ ++
Sbjct: 64 DKLASLTAQTK-----ADHLNWSTPKTLDK--HIFDSLSSLALLEE--PGLTKVQQAAVV 114
Query: 592 SFLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQL 744
SFLY++ + + S + + S L IGAG GSSAS VCLA L+ L
Sbjct: 115 SFLYLYIHLCPPSVCE-DSSNWVVRSTLPIGAGLGSSASICVCLAAGLLVL 164
>UniRef50_A7SJK4 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 415
Score = 75.4 bits (177), Expect = 2e-12
Identities = 60/175 (34%), Positives = 97/175 (55%), Gaps = 1/175 (0%)
Frame = +1
Query: 217 LFTVSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQ 396
L V VSAPGK+ILHGEH+VVYGK AIAVS+GLR+++V++ +E V + L +D
Sbjct: 3 LSRVVVSAPGKIILHGEHAVVYGKAAIAVSIGLRTTVVLQ--RHKNESKVSLLLKDLDYI 60
Query: 397 ETIPLEPTVKSLFHPKLAPGITGKFSWRLPHKIDHDYHLRRVEEYLHLIKPNFDSLPNNQ 576
T L K L P ++ R + D L +++ + K F +
Sbjct: 61 LTWDLTDIQKILV---AVPQVS-----RTDTVLPSDEMLSLIDKLIDSSK--FVEV-EGV 109
Query: 577 KNSLRSFLYVF-SGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALI 738
K++ R FL++ S + LP ++++ + + L +GAG GSSA++++ LA A++
Sbjct: 110 KDAARVFLFLMTSTLRDRDRLP--AIEVEVKTALPLGAGLGSSAAYSISLAAAML 162
>UniRef50_Q03426 Cluster: Mevalonate kinase; n=26; Euteleostomi|Rep:
Mevalonate kinase - Homo sapiens (Human)
Length = 396
Score = 73.3 bits (172), Expect = 7e-12
Identities = 62/171 (36%), Positives = 95/171 (55%), Gaps = 2/171 (1%)
Frame = +1
Query: 232 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPA-VHIHLPCVDLQETIP 408
VSAPGKVILHGEH+VV+GK A+AVSL LR+ + ++ PH V + LP + ++
Sbjct: 8 VSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQ----PHSNGKVDLSLPNIGIKRAWD 63
Query: 409 LEPTVKSLFHPKLAPG-ITGKFSWRLPHKIDHDYHLRRVEEYLHLIKPNFDSLPNNQKNS 585
+ ++SL L G +T S + +++E L P D ++ +
Sbjct: 64 V-ARLQSLDTSFLEQGDVTTPTS----------EQVEKLKEVAGL--P--DDCAVTERLA 108
Query: 586 LRSFLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALI 738
+ +FLY++ I + S+DI + SEL GAG GSSA+++VCLA AL+
Sbjct: 109 VLAFLYLYLSIC-RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALL 158
>UniRef50_A3LQ81 Cluster: Mevalonate kinase; n=5;
Saccharomycetales|Rep: Mevalonate kinase - Pichia
stipitis (Yeast)
Length = 432
Score = 68.1 bits (159), Expect = 3e-10
Identities = 60/186 (32%), Positives = 91/186 (48%), Gaps = 5/186 (2%)
Frame = +1
Query: 232 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDL-----Q 396
VSAPGKVI+ GEHS VYGK AIA +L LR+ +++ P +++ P ++L +
Sbjct: 7 VSAPGKVIIFGEHSAVYGKPAIAAALSLRAYLLVTPSQDP--DTINLSFPDINLTHSWNK 64
Query: 397 ETIPLEPTVKSLFHPKLAPGITGKFSWRLPHKIDHDYHLRRVEEYLHLIKPNFDSLPNNQ 576
IP + VK H L + +P +D L + + +S +
Sbjct: 65 NDIPWDSIVK---HINLVDNLPQTSEELVPEIVDQ----------LGSVLADLNS--SLH 109
Query: 577 KNSLRSFLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQLLKLK 756
+ FLY+++ + + M + S L IGAG GSSAS AVCLA AL +L +
Sbjct: 110 YTACLCFLYLYTHLCNQ---ELAGMSFCIRSTLPIGAGLGSSASTAVCLASAL-AILGNR 165
Query: 757 SSSGNF 774
+S +F
Sbjct: 166 VTSASF 171
>UniRef50_Q7PWI8 Cluster: ENSANGP00000021364; n=2; Culicidae|Rep:
ENSANGP00000021364 - Anopheles gambiae str. PEST
Length = 402
Score = 65.7 bits (153), Expect = 1e-09
Identities = 56/174 (32%), Positives = 84/174 (48%)
Frame = +1
Query: 232 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQETIPL 411
VSAPGKVILHGEHSVVYG AIA S+GL + + T E +V I + T+ L
Sbjct: 11 VSAPGKVILHGEHSVVYGHPAIAGSIGLHTYLNY----TALERSVIIEFRSIPFTATLTL 66
Query: 412 EPTVKSLFHPKLAPGITGKFSWRLPHKIDHDYHLRRVEEYLHLIKPNFDSLPNNQKNSLR 591
+ L + + + ++ + + + R + P + + ++ SL
Sbjct: 67 DSFGAFLREVDCSETLQPE-AFLEQLRSEGAFPFARFLS-PGPVPPVLEETSSKERMSLG 124
Query: 592 SFLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQLLKL 753
S + S F +S+ SE++IGAG GSSAS+ VCLA QL ++
Sbjct: 125 S---IDSTFFSEEASGGGGFRLSLYSEMSIGAGLGSSASYGVCLAAGAYQLSRI 175
>UniRef50_Q86AG7 Cluster: Similar to Rattus norvegicus (Rat).
Mevalonate kinase; n=2; Dictyostelium discoideum|Rep:
Similar to Rattus norvegicus (Rat). Mevalonate kinase -
Dictyostelium discoideum (Slime mold)
Length = 390
Score = 60.9 bits (141), Expect = 4e-08
Identities = 61/187 (32%), Positives = 94/187 (50%), Gaps = 5/187 (2%)
Frame = +1
Query: 196 MLTAVDNLFTVSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIH 375
M++ DN+ + VSAPGK+IL GEH+VV KTAIA +L LR+++ TP
Sbjct: 1 MISNQDNI--IQVSAPGKIILFGEHAVVLEKTAIASALSLRTTVTF----TP-------- 46
Query: 376 LPCVDLQETIPLEPTVKSLFHPKLAPGITGKFSWRLPH--KIDH---DYHLRRVEEYLHL 540
+ T+ L+ P LA G G W L K+DH D + + E L
Sbjct: 47 ----NTNNTLLLD-------FPDLA-GF-GVREWSLDEFKKLDHFPNDIDILKPIECSEL 93
Query: 541 IKPNFDSLPNNQKNSLRSFLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVC 720
+ + + + + + +FL++F + T K+ +I + S+L IGAG GSSASF V
Sbjct: 94 FQQELNKIIDIK--GIHTFLFLFCALTKCT----KAYNIKITSDLPIGAGLGSSASFCVS 147
Query: 721 LAGALIQ 741
+ L++
Sbjct: 148 ICAGLLK 154
>UniRef50_Q65XX9 Cluster: Putative uncharacterized protein; n=5;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 614
Score = 59.7 bits (138), Expect = 9e-08
Identities = 45/170 (26%), Positives = 86/170 (50%)
Frame = +1
Query: 232 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQETIPL 411
VSAPGK+IL GEH+VVYG+TAIA S+ LR+ + + T + +++ LP + +++T L
Sbjct: 144 VSAPGKIILFGEHAVVYGRTAIAGSIDLRTYV---SLYTSADGRIYLSLPDLGVEKTWML 200
Query: 412 EPTVKSLFHPKLAPGITGKFSWRLPHKIDHDYHLRRVEEYLHLIKPNFDSLPNNQKNSLR 591
+ +K+ + + P + D L + + + + Q ++
Sbjct: 201 KDLLKA----------ADRLAAEYPIEEDQPPSLEILVPIARKLSGSCEDQCGVQHLAIL 250
Query: 592 SFLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQ 741
+F Y+ G+ + ++ ++ +L G GSS ++ VC+A +L+Q
Sbjct: 251 AFWYLLLGV-AHRKRDLLAVKATVRFKLPSCVGLGSSGAYCVCIATSLLQ 299
>UniRef50_UPI000155619E Cluster: PREDICTED: hypothetical protein,
partial; n=1; Ornithorhynchus anatinus|Rep: PREDICTED:
hypothetical protein, partial - Ornithorhynchus anatinus
Length = 282
Score = 56.8 bits (131), Expect = 6e-07
Identities = 33/82 (40%), Positives = 49/82 (59%)
Frame = +1
Query: 223 TVSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQET 402
T+ VSAPGK ILHGEHSVV+GK A+AV+L LR+ + + + V + LP + L+ T
Sbjct: 5 TLVVSAPGKAILHGEHSVVHGKVALAVALNLRTFL---QFRPGDQDRVTVSLPNLGLRRT 61
Query: 403 IPLEPTVKSLFHPKLAPGITGK 468
+ ++ +F L P G+
Sbjct: 62 WEVS-GLRLVFPEPLGPSPVGR 82
Score = 43.2 bits (97), Expect = 0.008
Identities = 29/98 (29%), Positives = 50/98 (51%)
Frame = +1
Query: 484 PHKIDHDYHLRRVEEYLHLIKPNFDSLPNNQKNSLRSFLYVFSGIFGSTYLPVKSMDISM 663
P + + +++E+ L DS Q +L +FLY+++ I G T +D+++
Sbjct: 144 PSAVPTPERMEKLKEFAGLAPGPLDS----QGLALLAFLYLYTAI-GGTDGAWPGVDVTV 198
Query: 664 GSELTIGAGTGSSASFAVCLAGALIQLLKLKSSSGNFD 777
SEL G G GSSA+++ C A A + L S+ + D
Sbjct: 199 WSELPPGGGLGSSAAYSACSASAWLSALDTVSAPWDHD 236
>UniRef50_Q7K2V9 Cluster: GH04687p; n=1; Drosophila
melanogaster|Rep: GH04687p - Drosophila melanogaster
(Fruit fly)
Length = 390
Score = 56.4 bits (130), Expect = 8e-07
Identities = 52/199 (26%), Positives = 90/199 (45%), Gaps = 7/199 (3%)
Frame = +1
Query: 232 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQETIPL 411
V +PGKVILHGEH+VVY + A+A +GL +++ +++ + + L+ +P
Sbjct: 6 VHSPGKVILHGEHAVVYHRPALAAVVGLGTTLRFRQLEDSQVASFQLEALNCTLEIQLPE 65
Query: 412 EPTVKSLFHPKLAPGITGKFSWRLPHKIDHDYHLRRVEEYLHLIKPNFDSLPNNQKNSLR 591
+ F K T R E L + ++ + + +
Sbjct: 66 FNGFLAEFRSKYPSDSTANL-----------LEAVRAEVSKQLERSGGNAPKQHTQRAFI 114
Query: 592 SFLYVFSGIF----GSTYLPVKS-MDISMGSELTIGAGTGSSASFAVCLAGALIQLLKLK 756
S Y+ +G G L +++ + + S+LT+GAG GSSASF LA + L
Sbjct: 115 SIYYLLAGAVLSAPGDKKLTLQTGFQVQVDSQLTVGAGLGSSASFGAALATTFLIL---- 170
Query: 757 SSSGNF--DAYYDQSSQDL 807
+G+F D+Y +++Q L
Sbjct: 171 --AGHFDRDSYLSEANQAL 187
>UniRef50_Q756D2 Cluster: AER335Wp; n=3; Saccharomycetaceae|Rep:
AER335Wp - Ashbya gossypii (Yeast) (Eremothecium
gossypii)
Length = 428
Score = 54.8 bits (126), Expect = 3e-06
Identities = 54/170 (31%), Positives = 84/170 (49%)
Frame = +1
Query: 235 SAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQETIPLE 414
SAPGKVI+ GEHS VY K AIA S+ + + E + + AV + P + Q + E
Sbjct: 19 SAPGKVIIFGEHSAVYNKPAIAASVSSLRTYLFVEADAESD-AVRMEFPDIGFQYSWKHE 77
Query: 415 PTVKSLFHPKLAPGITGKFSWRLPHKIDHDYHLRRVEEYLHLIKPNFDSLPNNQKNSLRS 594
P+ A + F R ++D + L V+ L ++ +++
Sbjct: 78 ALTAV---PREA--VVRAFCSR---ELDAEV-LAHVDRLLMGLEGAL------ARHAALC 122
Query: 595 FLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQL 744
FLY+++ + V+ + ++ S L IGAG GSSAS AVCLA A+ +L
Sbjct: 123 FLYIYTCLCRE----VQGVRFTVKSTLPIGAGLGSSASIAVCLALAMGRL 168
>UniRef50_Q2HTL9 Cluster: Mevalonate and galactokinase; n=5; core
eudicotyledons|Rep: Mevalonate and galactokinase -
Medicago truncatula (Barrel medic)
Length = 388
Score = 54.4 bits (125), Expect = 3e-06
Identities = 49/175 (28%), Positives = 86/175 (49%), Gaps = 4/175 (2%)
Frame = +1
Query: 226 VSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTP---HEPAVHIHLPCVDLQ 396
V APGK+IL GEH+VV+G TA+A S+ L + + ++ +TP +E ++ + L L+
Sbjct: 3 VKARAPGKIILAGEHAVVHGSTAVASSIDLYTYVSLR-FSTPSSENEESLRLLLKDTALE 61
Query: 397 ETIPLEPTVKSLFHPKLAPGITGKFSWRLPHKIDHDYHLRRVEEYLHLIKP-NFDSLPNN 573
P+ ++ F P+ S L + + + L++ N
Sbjct: 62 FEWPIS-RIREAF-PE---------SVSLLSSTPNSCSVECAKSIASLVEELNIPEAKIG 110
Query: 574 QKNSLRSFLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALI 738
+ + +FL+++S I G K + + S+L +G+G GSSA+F V LA A +
Sbjct: 111 LASGVAAFLWLYSSIQG-----FKPATVVINSDLPLGSGLGSSAAFCVALAAAFL 160
>UniRef50_Q09780 Cluster: Putative mevalonate kinase; n=1;
Schizosaccharomyces pombe|Rep: Putative mevalonate
kinase - Schizosaccharomyces pombe (Fission yeast)
Length = 404
Score = 54.4 bits (125), Expect = 3e-06
Identities = 48/172 (27%), Positives = 80/172 (46%), Gaps = 3/172 (1%)
Frame = +1
Query: 232 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCV---DLQET 402
VS+PGK IL GEH+VVYG TA+A ++ LRS ++ N V + +LQ
Sbjct: 7 VSSPGKTILFGEHAVVYGATALAAAVSLRSYCKLQTTNNNEIVIVMSDIGTERRWNLQSL 66
Query: 403 IPLEPTVKSLFHPKLAPGITGKFSWRLPHKIDHDYHLRRVEEYLHLIKPNFDSLPNNQKN 582
TV+++ HP +P L L++ + L N +
Sbjct: 67 PWQHVTVENVQHPASSPN-------------------------LDLLQGLGELLKNEENG 101
Query: 583 SLRSFLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALI 738
+ S + +F S P + +++ S++ +GAG GSSA+ +V +A +L+
Sbjct: 102 LIHSAMLCTLYLFTSLSSPSQGCTLTISSQVPLGAGLGSSATISVVVATSLL 153
>UniRef50_P07277 Cluster: Mevalonate kinase; n=3;
Saccharomycetales|Rep: Mevalonate kinase - Saccharomyces
cerevisiae (Baker's yeast)
Length = 443
Score = 54.0 bits (124), Expect = 5e-06
Identities = 51/172 (29%), Positives = 79/172 (45%), Gaps = 2/172 (1%)
Frame = +1
Query: 235 SAPGKVILHGEHSVVYGKTAIAVSL-GLRSSIVIKEVNTPHEPAVHIHLPCVDLQETIPL 411
SAPGKVI+ GEHS VY K A+A S+ LR+ ++I E + P + + P + +
Sbjct: 8 SAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAP--DTIELDFPDISFNHKWSI 65
Query: 412 EPTVKSLFHPKLAPGITGKFSWRLPHKIDHDYHLRRVEEYLHLIKPNFDSLPNN-QKNSL 588
F+ + + + D +E + L+ P L + ++
Sbjct: 66 ND-----FNAITEDQVNSQKLAKAQQATD-----GLSQELVSLLDPLLAQLSESFHYHAA 115
Query: 589 RSFLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQL 744
FLY+F + K++ S+ S L IGAG GSSAS +V LA A+ L
Sbjct: 116 FCFLYMFVCLCPH----AKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYL 163
>UniRef50_UPI0000DB6B27 Cluster: PREDICTED: similar to Mevalonate
kinase (MK); n=1; Apis mellifera|Rep: PREDICTED: similar
to Mevalonate kinase (MK) - Apis mellifera
Length = 359
Score = 52.4 bits (120), Expect = 1e-05
Identities = 24/37 (64%), Positives = 30/37 (81%)
Frame = +1
Query: 232 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEV 342
VSAPGKVIL GEH+VVYGKTA+A S+ LR+ + E+
Sbjct: 6 VSAPGKVILFGEHAVVYGKTAVAASIDLRTVLNFTEL 42
Score = 49.6 bits (113), Expect = 1e-04
Identities = 29/78 (37%), Positives = 40/78 (51%)
Frame = +1
Query: 574 QKNSLRSFLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQLLKL 753
QK SL +F Y I + +K I + +EL I +G GSSASFAVCLA + L
Sbjct: 81 QKLSLEAFFYTLIYIAQKEEMEIKPFQIQLNTELAINSGLGSSASFAVCLAACFVHWSHL 140
Query: 754 KSSSGNFDAYYDQSSQDL 807
+ N +D S+ D+
Sbjct: 141 QK---NIYKVFDFSTLDV 155
>UniRef50_P46086 Cluster: Mevalonate kinase; n=8; Magnoliophyta|Rep:
Mevalonate kinase - Arabidopsis thaliana (Mouse-ear
cress)
Length = 378
Score = 50.4 bits (115), Expect = 6e-05
Identities = 49/194 (25%), Positives = 88/194 (45%)
Frame = +1
Query: 226 VSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQETI 405
V APGK+IL GEH+VV+G TA+A ++ L + + ++ E + L D I
Sbjct: 3 VKARAPGKIILAGEHAVVHGSTAVAAAIDLYTYVTLRFPLPSAENNDRLTLQLKD----I 58
Query: 406 PLEPTVKSLFHPKLAPGITGKFSWRLPHKIDHDYHLRRVEEYLHLIKPNFDSLPNNQKNS 585
LE + + P + P + L+ + + + N +
Sbjct: 59 SLEFSWSLARIKEAIPYDSSTLCRSTPASCSEE-TLKSIAVLVE--EQNLPKEKMWLSSG 115
Query: 586 LRSFLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQLLKLKSSS 765
+ +FL++++ I G + P + + SEL G+G GSSA+ V L AL+ + +
Sbjct: 116 ISTFLWLYTRIIG--FNPA---TVVINSELPYGSGLGSSAALCVALTAALLASSISEKTR 170
Query: 766 GNFDAYYDQSSQDL 807
GN + D+++ +L
Sbjct: 171 GNGWSSLDETNLEL 184
>UniRef50_Q4TG59 Cluster: Chromosome undetermined SCAF3891, whole
genome shotgun sequence; n=2; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF3891,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 173
Score = 48.8 bits (111), Expect = 2e-04
Identities = 29/62 (46%), Positives = 40/62 (64%), Gaps = 7/62 (11%)
Frame = +1
Query: 226 VSVSAPGKVILHGEHSVVYGKT-------AIAVSLGLRSSIVIKEVNTPHEPAVHIHLPC 384
+ VSAPGK ILHGEH+VV+GK A+AVSL LRS + ++ +T V ++LP
Sbjct: 1 IYVSAPGKAILHGEHAVVHGKVTSNKAKMALAVSLNLRSYLRLEATST---GTVGVNLPN 57
Query: 385 VD 390
+D
Sbjct: 58 ID 59
Score = 44.0 bits (99), Expect = 0.005
Identities = 26/64 (40%), Positives = 36/64 (56%)
Frame = +1
Query: 547 PNFDSLPNNQKNSLRSFLYVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLA 726
PN D+ + + L+ F SG T L + +S+ SEL GAG GSSA++ VCLA
Sbjct: 56 PNIDTFLHWNLSELKQFAPSVSGNEQLT-LGAAQLTVSVWSELPTGAGLGSSAAYTVCLA 114
Query: 727 GALI 738
AL+
Sbjct: 115 AALL 118
>UniRef50_A2SR97 Cluster: Mevalonate kinase; n=4;
Methanomicrobiales|Rep: Mevalonate kinase -
Methanocorpusculum labreanum (strain ATCC 43576 / DSM
4855 / Z)
Length = 290
Score = 47.6 bits (108), Expect = 4e-04
Identities = 22/42 (52%), Positives = 29/42 (69%)
Frame = +1
Query: 235 SAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEP 360
SAPGKVIL GEHSVVYGK AIA+++ R + ++ +P
Sbjct: 5 SAPGKVILFGEHSVVYGKPAIAMAIKPRVQVTVRHSRYYQKP 46
>UniRef50_Q8TT37 Cluster: Mevalonate kinase; n=5; Euryarchaeota|Rep:
Mevalonate kinase - Methanosarcina acetivorans
Length = 305
Score = 46.4 bits (105), Expect = 0.001
Identities = 19/37 (51%), Positives = 29/37 (78%)
Frame = +1
Query: 226 VSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIK 336
+S SAPGK+ L GEH+VVYG+TAI ++ LR+ + ++
Sbjct: 6 ISCSAPGKIYLFGEHAVVYGETAIGCAIELRTRVRVE 42
>UniRef50_Q50559 Cluster: Mevalonate kinase; n=2;
Methanothermobacter thermautotrophicus str. Delta H|Rep:
Mevalonate kinase - Methanobacterium thermoautotrophicum
Length = 303
Score = 46.0 bits (104), Expect = 0.001
Identities = 20/42 (47%), Positives = 28/42 (66%)
Frame = +1
Query: 229 SVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPH 354
S SAP K IL GEH+VVY K AIA ++ R ++ + E ++ H
Sbjct: 4 SASAPAKAILFGEHAVVYSKPAIAAAIDRRVTVTVSESSSTH 45
>UniRef50_Q0LHN3 Cluster: Mevalonate kinase; n=2; Chloroflexi
(class)|Rep: Mevalonate kinase - Herpetosiphon
aurantiacus ATCC 23779
Length = 313
Score = 45.6 bits (103), Expect = 0.002
Identities = 23/54 (42%), Positives = 36/54 (66%), Gaps = 1/54 (1%)
Frame = +1
Query: 235 SAPGKVILHGEHSVVYGKTAIAVSL-GLRSSIVIKEVNTPHEPAVHIHLPCVDL 393
SAPGK+IL GEH+VVYG+ A+A+ + LR+S+ ++ P + +H P + L
Sbjct: 3 SAPGKLILAGEHAVVYGQPALAMPIAALRASVAVEP--APRGAGMTVHAPDLGL 54
>UniRef50_A0B6E3 Cluster: Mevalonate kinase; n=1; Methanosaeta
thermophila PT|Rep: Mevalonate kinase - Methanosaeta
thermophila (strain DSM 6194 / PT)
(Methanothrixthermophila (strain DSM 6194 / PT))
Length = 321
Score = 45.6 bits (103), Expect = 0.002
Identities = 19/47 (40%), Positives = 33/47 (70%)
Frame = +1
Query: 229 SVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVH 369
+ SAPGKVIL GEH+VV G A+ ++ LR+ ++++++ E ++H
Sbjct: 3 AASAPGKVILFGEHAVVSGAPALGTAIDLRARVLVEDLPGKTEISIH 49
>UniRef50_Q9V187 Cluster: Mevalonate kinase; n=4;
Thermococcaceae|Rep: Mevalonate kinase - Pyrococcus
abyssi
Length = 335
Score = 45.6 bits (103), Expect = 0.002
Identities = 21/34 (61%), Positives = 26/34 (76%)
Frame = +1
Query: 226 VSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSI 327
V SAP K+IL GEHSVVYGK AIA ++ LR+ +
Sbjct: 5 VLASAPAKIILFGEHSVVYGKPAIASAIDLRTYV 38
Score = 36.3 bits (80), Expect = 0.97
Identities = 17/38 (44%), Positives = 27/38 (71%)
Frame = +1
Query: 649 MDISMGSELTIGAGTGSSASFAVCLAGALIQLLKLKSS 762
+ +S+ S++ +GAG GSSA+ AV GA+ +LL L+ S
Sbjct: 102 VSVSITSQIPVGAGLGSSAAVAVATIGAVSKLLDLELS 139
>UniRef50_Q58487 Cluster: Mevalonate kinase; n=1; Methanocaldococcus
jannaschii|Rep: Mevalonate kinase - Methanococcus
jannaschii
Length = 312
Score = 44.4 bits (100), Expect = 0.004
Identities = 20/36 (55%), Positives = 27/36 (75%)
Frame = +1
Query: 232 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKE 339
+ P KVIL GEH+VVYG AI++++ L S+I IKE
Sbjct: 3 IETPSKVILFGEHAVVYGYRAISMAIDLTSTIEIKE 38
>UniRef50_O27995 Cluster: Mevalonate kinase; n=1; Archaeoglobus
fulgidus|Rep: Mevalonate kinase - Archaeoglobus fulgidus
Length = 284
Score = 44.0 bits (99), Expect = 0.005
Identities = 17/35 (48%), Positives = 27/35 (77%)
Frame = +1
Query: 235 SAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKE 339
SAPGK+IL GEH+VVYG+ A+ ++ LR + +++
Sbjct: 4 SAPGKIILFGEHAVVYGRHAVVSAINLRCRVSVRK 38
>UniRef50_UPI000155611C Cluster: PREDICTED: hypothetical protein,
partial; n=1; Ornithorhynchus anatinus|Rep: PREDICTED:
hypothetical protein, partial - Ornithorhynchus anatinus
Length = 269
Score = 43.6 bits (98), Expect = 0.006
Identities = 27/85 (31%), Positives = 46/85 (54%)
Frame = +1
Query: 484 PHKIDHDYHLRRVEEYLHLIKPNFDSLPNNQKNSLRSFLYVFSGIFGSTYLPVKSMDISM 663
P + + +++E+ L DS Q +L +FLY+++ I G T +D+++
Sbjct: 68 PSAVPTPEQMEKLKEFAGLAPGPLDS----QGLALLAFLYLYTAI-GGTDGAWPGVDVTV 122
Query: 664 GSELTIGAGTGSSASFAVCLAGALI 738
SEL G G GSSA+++ CLA L+
Sbjct: 123 WSELPPGGGLGSSAAYSACLAACLL 147
>UniRef50_Q9HQI6 Cluster: Mevalonate kinase; n=5;
Halobacteriaceae|Rep: Mevalonate kinase - Halobacterium
salinarium (Halobacterium halobium)
Length = 330
Score = 43.2 bits (97), Expect = 0.008
Identities = 18/39 (46%), Positives = 27/39 (69%)
Frame = +1
Query: 223 TVSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKE 339
T + SAPGKV L GEH+VVYG+ A+ ++ R+ + + E
Sbjct: 2 TTTSSAPGKVYLFGEHAVVYGEPAVPCAIERRAHVTVSE 40
>UniRef50_A1RYL2 Cluster: Mevalonate kinase; n=1; Thermofilum
pendens Hrk 5|Rep: Mevalonate kinase - Thermofilum
pendens (strain Hrk 5)
Length = 322
Score = 42.7 bits (96), Expect = 0.011
Identities = 19/38 (50%), Positives = 27/38 (71%)
Frame = +1
Query: 235 SAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNT 348
SAP KVIL GEH VV G+ AIA ++ LR+ + ++ +T
Sbjct: 7 SAPAKVILFGEHFVVEGQPAIAAAISLRAHVTVEPADT 44
>UniRef50_A5UV63 Cluster: Mevalonate kinase; n=3;
Chloroflexaceae|Rep: Mevalonate kinase - Roseiflexus sp.
RS-1
Length = 314
Score = 41.9 bits (94), Expect = 0.019
Identities = 18/25 (72%), Positives = 22/25 (88%)
Frame = +1
Query: 235 SAPGKVILHGEHSVVYGKTAIAVSL 309
SAPGK+IL GEH+VVYG+ AIA+ L
Sbjct: 4 SAPGKIILCGEHAVVYGRPAIAIPL 28
>UniRef50_A2E1U7 Cluster: Mevalonate kinase family protein; n=1;
Trichomonas vaginalis G3|Rep: Mevalonate kinase family
protein - Trichomonas vaginalis G3
Length = 315
Score = 40.7 bits (91), Expect = 0.045
Identities = 18/30 (60%), Positives = 23/30 (76%)
Frame = +1
Query: 229 SVSAPGKVILHGEHSVVYGKTAIAVSLGLR 318
S S PGKVIL GEH+VVYG+ A+A ++ R
Sbjct: 5 SFSFPGKVILFGEHAVVYGEAAVASAISRR 34
>UniRef50_A7DRD8 Cluster: Mevalonate kinase; n=1; Candidatus
Nitrosopumilus maritimus SCM1|Rep: Mevalonate kinase -
Candidatus Nitrosopumilus maritimus SCM1
Length = 313
Score = 40.7 bits (91), Expect = 0.045
Identities = 18/37 (48%), Positives = 26/37 (70%)
Frame = +1
Query: 235 SAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVN 345
SAPGKVIL GEH VVYG AI ++ R ++ ++++
Sbjct: 6 SAPGKVILFGEHFVVYGVKAILCAINKRIAVTAEKID 42
>UniRef50_UPI00015BB033 Cluster: mevalonate kinase; n=1; Ignicoccus
hospitalis KIN4/I|Rep: mevalonate kinase - Ignicoccus
hospitalis KIN4/I
Length = 321
Score = 39.9 bits (89), Expect = 0.079
Identities = 19/29 (65%), Positives = 21/29 (72%)
Frame = +1
Query: 223 TVSVSAPGKVILHGEHSVVYGKTAIAVSL 309
+VS AP KV L GEHSVVYGK AI S+
Sbjct: 2 SVSARAPTKVTLFGEHSVVYGKPAIVFSM 30
>UniRef50_Q2NG06 Cluster: Putative mevalonate kinase; n=1;
Methanosphaera stadtmanae DSM 3091|Rep: Putative
mevalonate kinase - Methanosphaera stadtmanae (strain
DSM 3091)
Length = 322
Score = 39.9 bits (89), Expect = 0.079
Identities = 17/28 (60%), Positives = 22/28 (78%)
Frame = +1
Query: 226 VSVSAPGKVILHGEHSVVYGKTAIAVSL 309
+ APGK+IL GEH+VVY K AIAV++
Sbjct: 3 IKAFAPGKIILFGEHTVVYKKPAIAVAI 30
>UniRef50_A5UN66 Cluster: Mevalonate kinase; n=1; Methanobrevibacter
smithii ATCC 35061|Rep: Mevalonate kinase -
Methanobrevibacter smithii (strain PS / ATCC 35061 / DSM
861)
Length = 320
Score = 39.9 bits (89), Expect = 0.079
Identities = 20/38 (52%), Positives = 25/38 (65%)
Frame = +1
Query: 235 SAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNT 348
SAP K IL GEHSVVY + AIA ++ R+ + I E T
Sbjct: 6 SAPAKTILFGEHSVVYDEPAIAGAVNKRAYVEITESKT 43
>UniRef50_A3H636 Cluster: Mevalonate kinase; n=1; Caldivirga
maquilingensis IC-167|Rep: Mevalonate kinase -
Caldivirga maquilingensis IC-167
Length = 334
Score = 39.9 bits (89), Expect = 0.079
Identities = 17/38 (44%), Positives = 27/38 (71%)
Frame = +1
Query: 226 VSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKE 339
V+ +APG V L GEH+VVYG+ AIA+++ + ++E
Sbjct: 6 VTATAPGVVKLFGEHAVVYGRPAIAMAINKGIKVTVEE 43
>UniRef50_Q74JA4 Cluster: Mevalonate kinase; n=7; Lactobacillus|Rep:
Mevalonate kinase - Lactobacillus johnsonii
Length = 305
Score = 39.5 bits (88), Expect = 0.10
Identities = 20/43 (46%), Positives = 28/43 (65%), Gaps = 1/43 (2%)
Frame = +1
Query: 226 VSVSAPGKVILHGEHSVVYGKTAIAVSL-GLRSSIVIKEVNTP 351
+ V A GKVIL GEHSVVYG A+A+ + L + ++E + P
Sbjct: 5 IEVKAHGKVILIGEHSVVYGYDALALPIQALNITTTVEETDGP 47
>UniRef50_Q2BIK0 Cluster: Mevalonate kinase, putative; n=1;
Neptuniibacter caesariensis|Rep: Mevalonate kinase,
putative - Neptuniibacter caesariensis
Length = 327
Score = 39.5 bits (88), Expect = 0.10
Identities = 17/33 (51%), Positives = 24/33 (72%)
Frame = +1
Query: 226 VSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSS 324
+ APGK+IL GEHSVVYG AIA ++ +++
Sbjct: 1 MKAQAPGKLILSGEHSVVYGAPAIATAVAQQAT 33
>UniRef50_Q8TWN9 Cluster: Mevalonate kinase; n=1; Methanopyrus
kandleri|Rep: Mevalonate kinase - Methanopyrus kandleri
Length = 328
Score = 39.1 bits (87), Expect = 0.14
Identities = 18/28 (64%), Positives = 22/28 (78%)
Frame = +1
Query: 226 VSVSAPGKVILHGEHSVVYGKTAIAVSL 309
+SV AP K IL GEH+VVYG A+AV+L
Sbjct: 3 ISVKAPLKAILAGEHAVVYGYPAVAVAL 30
>UniRef50_A3HYY0 Cluster: Galactokinase; n=1; Algoriphagus sp.
PR1|Rep: Galactokinase - Algoriphagus sp. PR1
Length = 382
Score = 38.7 bits (86), Expect = 0.18
Identities = 20/57 (35%), Positives = 31/57 (54%)
Frame = +1
Query: 637 PVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQLLKLKSSSGNFDAYYDQSSQDL 807
PVK DI G ++ +G+G SSA+ +V + A+ + K S + A Y Q S+ L
Sbjct: 103 PVKGFDIVFGGDIPVGSGLSSSAALSVAIGTAISAVFDFKISKKSI-AIYAQKSEHL 158
>UniRef50_A2BL67 Cluster: Mevalonate kinase; n=1; Hyperthermus
butylicus DSM 5456|Rep: Mevalonate kinase - Hyperthermus
butylicus (strain DSM 5456 / JCM 9403)
Length = 316
Score = 38.7 bits (86), Expect = 0.18
Identities = 17/29 (58%), Positives = 23/29 (79%)
Frame = +1
Query: 235 SAPGKVILHGEHSVVYGKTAIAVSLGLRS 321
SAP KVI+ GEH VV+G A+A ++GLR+
Sbjct: 6 SAPAKVIVFGEHWVVHGGLALAAAIGLRA 34
>UniRef50_Q9Y946 Cluster: Mevalonate kinase; n=1; Aeropyrum
pernix|Rep: Mevalonate kinase - Aeropyrum pernix
Length = 324
Score = 38.7 bits (86), Expect = 0.18
Identities = 17/34 (50%), Positives = 23/34 (67%)
Frame = +1
Query: 235 SAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIK 336
SAPGKVI+ GEH VV G AI ++G R + ++
Sbjct: 8 SAPGKVIIVGEHFVVRGSLAIVAAIGRRLRVTVR 41
>UniRef50_Q8L1I1 Cluster: Phosphomevalonate kinase; n=1; Paracoccus
zeaxanthinifaciens|Rep: Phosphomevalonate kinase -
Paracoccus zeaxanthinifaciens
Length = 305
Score = 38.3 bits (85), Expect = 0.24
Identities = 16/36 (44%), Positives = 23/36 (63%)
Frame = +1
Query: 226 VSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVI 333
+ SAPG V++ GEH+VVYG AI + R+ + I
Sbjct: 5 IRASAPGSVMITGEHAVVYGHRAIVAGIEQRAHVTI 40
>UniRef50_A6G140 Cluster: Hydroxymethylglutaryl-CoA reductase; n=1;
Plesiocystis pacifica SIR-1|Rep:
Hydroxymethylglutaryl-CoA reductase - Plesiocystis
pacifica SIR-1
Length = 810
Score = 38.3 bits (85), Expect = 0.24
Identities = 16/34 (47%), Positives = 26/34 (76%)
Frame = +1
Query: 220 FTVSVSAPGKVILHGEHSVVYGKTAIAVSLGLRS 321
+T +VSAPGK L GE++V+YG +AI ++ +R+
Sbjct: 43 YTGTVSAPGKAFLIGEYAVLYGHSAIVTAVDVRA 76
>UniRef50_Q6LXL5 Cluster: Mevalonate kinase; n=5; Methanococcus|Rep:
Mevalonate kinase - Methanococcus maripaludis
Length = 317
Score = 38.3 bits (85), Expect = 0.24
Identities = 26/78 (33%), Positives = 44/78 (56%), Gaps = 1/78 (1%)
Frame = +1
Query: 229 SVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQETIP 408
++ P K+IL GEH+VV G AI+++L L+++ I+E + + I L VDL E
Sbjct: 3 TIKTPSKIILFGEHAVVDGYPAISMALDLKTTGEIEE----NFDTISIDL--VDLNEIFE 56
Query: 409 LEP-TVKSLFHPKLAPGI 459
+ P +K+L +P +
Sbjct: 57 ITPELIKNLEISNFSPAL 74
>UniRef50_Q8L1I2 Cluster: Mevalonate kinase; n=1; Paracoccus
zeaxanthinifaciens|Rep: Mevalonate kinase - Paracoccus
zeaxanthinifaciens
Length = 378
Score = 37.5 bits (83), Expect = 0.42
Identities = 15/24 (62%), Positives = 21/24 (87%)
Frame = +1
Query: 238 APGKVILHGEHSVVYGKTAIAVSL 309
APGK+IL GEHSV+YG A+A+++
Sbjct: 12 APGKLILSGEHSVLYGAPALAMAI 35
>UniRef50_A5EVP5 Cluster: GHMP kinase family protein; n=1;
Dichelobacter nodosus VCS1703A|Rep: GHMP kinase family
protein - Dichelobacter nodosus (strain VCS1703A)
Length = 303
Score = 37.5 bits (83), Expect = 0.42
Identities = 20/60 (33%), Positives = 32/60 (53%)
Frame = +1
Query: 223 TVSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQET 402
T+ SA G V++ GEH+VVYG+ AI ++ R + + N + + IH D + T
Sbjct: 2 TIETSASGSVMICGEHAVVYGQPAIVAAIAQRIRVRLTPRN---DDKITIHSALGDYEST 58
>UniRef50_A5EUV5 Cluster: GHMP kinase family protein; n=1;
Dichelobacter nodosus VCS1703A|Rep: GHMP kinase family
protein - Dichelobacter nodosus (strain VCS1703A)
Length = 352
Score = 37.5 bits (83), Expect = 0.42
Identities = 16/24 (66%), Positives = 20/24 (83%)
Frame = +1
Query: 238 APGKVILHGEHSVVYGKTAIAVSL 309
APGK+IL GEH+VVYG AI V++
Sbjct: 8 APGKLILSGEHAVVYGAPAIVVAV 31
>UniRef50_Q83DT3 Cluster: Mevalonate kinase, putative; n=3; Coxiella
burnetii|Rep: Mevalonate kinase, putative - Coxiella
burnetii
Length = 340
Score = 37.1 bits (82), Expect = 0.55
Identities = 50/169 (29%), Positives = 73/169 (43%)
Frame = +1
Query: 241 PGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQETIPLEPT 420
P K+IL GEH+VVYG A++V++ ++ H H +D + E T
Sbjct: 11 PAKLILSGEHAVVYGHPALSVAINRYMEATVRWSLPLH---FSFHFMGIDFRR----EVT 63
Query: 421 VKSLFHPKLAPGITGKFSWRLPHKIDHDYHLRRVEEYLHLIKPNFDSLPNNQKNSLRSFL 600
+++L + K R K H Y L + L KP F+ SL +F+
Sbjct: 64 LQALRNLK-----------RKLKKQYHKYSLGHLSIREVLQKP-FEL-------SLFTFI 104
Query: 601 YVFSGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQLL 747
V + LP +DI S + +G G GSSA+ V L AL Q L
Sbjct: 105 NVLDRL--KNKLPT-GIDIVTDSNIPVGCGMGSSAASVVSLIYALTQFL 150
>UniRef50_Q22LZ8 Cluster: ATPase, AAA family protein; n=1;
Tetrahymena thermophila SB210|Rep: ATPase, AAA family
protein - Tetrahymena thermophila SB210
Length = 741
Score = 37.1 bits (82), Expect = 0.55
Identities = 23/72 (31%), Positives = 40/72 (55%), Gaps = 1/72 (1%)
Frame = +1
Query: 139 LYLA*DLVNFACAYY-IKRTMLTAVDNLFTVSVSAPGKVILHGEHSVVYGKTAIAVSLGL 315
+Y + L+N+ AY I + M+ ++D + T S +++ G S+ GKTAIA + L
Sbjct: 502 VYKSNKLINYGEAYERISKQMIQSIDYVKTSENSLIHSILIEG--SIGTGKTAIAAAFAL 559
Query: 316 RSSIVIKEVNTP 351
+S I ++ TP
Sbjct: 560 KSDITYVKILTP 571
>UniRef50_A0E671 Cluster: Chromosome undetermined scaffold_8, whole
genome shotgun sequence; n=3; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_8,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 288
Score = 37.1 bits (82), Expect = 0.55
Identities = 16/34 (47%), Positives = 23/34 (67%)
Frame = +1
Query: 232 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVI 333
V AP K+I+ GEHSVVYG A+ ++ ++I I
Sbjct: 3 VRAPAKIIISGEHSVVYGHKALCAAINKYTTIKI 36
>UniRef50_Q7QVN5 Cluster: GLP_305_18405_19430; n=1; Giardia lamblia
ATCC 50803|Rep: GLP_305_18405_19430 - Giardia lamblia
ATCC 50803
Length = 341
Score = 36.3 bits (80), Expect = 0.97
Identities = 18/31 (58%), Positives = 21/31 (67%)
Frame = +1
Query: 232 VSAPGKVILHGEHSVVYGKTAIAVSLGLRSS 324
V P K IL GEHSVVYG IA++L L +S
Sbjct: 13 VRTPLKAILSGEHSVVYGHPCIAMALDLYTS 43
>UniRef50_Q4J2X7 Cluster: Putative uncharacterized protein; n=1;
Azotobacter vinelandii AvOP|Rep: Putative
uncharacterized protein - Azotobacter vinelandii AvOP
Length = 112
Score = 35.9 bits (79), Expect = 1.3
Identities = 14/35 (40%), Positives = 20/35 (57%)
Frame = +3
Query: 735 DTAVEIEEFFGEFRCILRSEQPRFTDTEKEIISEW 839
DT +EEF G RC++ S+ PR D E++ W
Sbjct: 63 DTLYLLEEFVGTTRCLVLSKTPRIPDRVDELVGHW 97
>UniRef50_Q03FN7 Cluster: Mevalonate kinase; n=1; Pediococcus
pentosaceus ATCC 25745|Rep: Mevalonate kinase -
Pediococcus pentosaceus (strain ATCC 25745 / 183-1w)
Length = 306
Score = 35.9 bits (79), Expect = 1.3
Identities = 17/38 (44%), Positives = 28/38 (73%), Gaps = 1/38 (2%)
Frame = +1
Query: 235 SAPGKVILHGEHSVVYGKTAIAVSL-GLRSSIVIKEVN 345
S+ K+IL GEHSVVYG+ AIA+ + +++++ I+ N
Sbjct: 7 SSNSKIILIGEHSVVYGQPAIALPIRNVKTTVKIQPTN 44
>UniRef50_A6G138 Cluster: Mevalonate kinase; n=1; Plesiocystis
pacifica SIR-1|Rep: Mevalonate kinase - Plesiocystis
pacifica SIR-1
Length = 320
Score = 35.9 bits (79), Expect = 1.3
Identities = 22/52 (42%), Positives = 28/52 (53%)
Frame = +1
Query: 238 APGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDL 393
A GK+IL GEHSVVYG A+A L R I+ A+ + +P DL
Sbjct: 11 ACGKIILLGEHSVVYGHPALAAGLS-RGLILRARPLDGRGGAMELSIPAWDL 61
>UniRef50_A2DPP4 Cluster: Phosphatidylinositol 3-and 4-kinase family
protein; n=1; Trichomonas vaginalis G3|Rep:
Phosphatidylinositol 3-and 4-kinase family protein -
Trichomonas vaginalis G3
Length = 2286
Score = 35.9 bits (79), Expect = 1.3
Identities = 36/125 (28%), Positives = 59/125 (47%), Gaps = 10/125 (8%)
Frame = +1
Query: 421 VKSLFHPKLAPGITGKFSWR---LPHKIDHDYHLRRVE-EYLHLIKPNFDSLPNNQKNSL 588
+ SL H P ++ F+W L K L + + E+L + P F L + K+S
Sbjct: 1741 ITSLLHCPSLPSMS-LFTWLVTFLDDKTAQRIDLTKFKSEFLVKLLPRFVDLLSKDKSSC 1799
Query: 589 RSFLYV----FSGIFGSTYLPVKS-MDISMGSELTIGAGTGSSASFAVCL-AGALIQLLK 750
RS + S F P++S + + SE+ + S ++ + + AG+LI LLK
Sbjct: 1800 RSIAKIVITRLSYDFQKVVFPLRSKIHVKEVSEILLNLCNSSEKNYKINVDAGSLINLLK 1859
Query: 751 LKSSS 765
+KSSS
Sbjct: 1860 MKSSS 1864
>UniRef50_Q83DT4 Cluster: Phosphomevalonate kinase, putative; n=2;
Coxiella burnetii|Rep: Phosphomevalonate kinase,
putative - Coxiella burnetii
Length = 313
Score = 35.5 bits (78), Expect = 1.7
Identities = 27/90 (30%), Positives = 41/90 (45%), Gaps = 4/90 (4%)
Frame = +1
Query: 238 APGKVILHGEHSVVYGKTAIAVSLGLRSSIVIK----EVNTPHEPAVHIHLPCVDLQETI 405
APG ++L GE++V+ GKTAI ++ SI + E P + L C ++ +
Sbjct: 7 APGSLMLLGEYAVLQGKTAIVAAIDKFISISLSPRHDEKINIDSPLGKLTLDCQSIKLSP 66
Query: 406 PLEPTVKSLFHPKLAPGITGKFSWRLPHKI 495
P E + +L KL G LP I
Sbjct: 67 PFEFVLAALASKKLPSGCDINIQSTLPPAI 96
>UniRef50_A2U564 Cluster: Mevalonate kinase; n=1; Bacillus coagulans
36D1|Rep: Mevalonate kinase - Bacillus coagulans 36D1
Length = 314
Score = 35.5 bits (78), Expect = 1.7
Identities = 16/27 (59%), Positives = 22/27 (81%)
Frame = +1
Query: 223 TVSVSAPGKVILHGEHSVVYGKTAIAV 303
T + +A GK+IL GEH+VVYG+ AIA+
Sbjct: 8 TATGTAHGKLILAGEHAVVYGQPAIAL 34
>UniRef50_Q6E6I3 Cluster: Mevalonate kinase-like protein; n=1;
Antonospora locustae|Rep: Mevalonate kinase-like protein
- Antonospora locustae (Nosema locustae)
Length = 311
Score = 35.1 bits (77), Expect = 2.2
Identities = 26/101 (25%), Positives = 48/101 (47%), Gaps = 4/101 (3%)
Frame = +1
Query: 181 YIKRT---MLTAVDNLFTVSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIK-EVNT 348
Y+K T ++++ T+ PGKV+L+G + V + IAV++ +++ + + +
Sbjct: 3 YLKNTNSCLVSSTTKKRTMRFRVPGKVVLNGGYLVCMEEECIAVNIDAYANVEAETDTES 62
Query: 349 PHEPAVHIHLPCVDLQETIPLEPTVKSLFHPKLAPGITGKF 471
P VH++ +T+ L T L A TGKF
Sbjct: 63 PQSTIVHLY------GDTVVLRITESGLIIDSAADADTGKF 97
>UniRef50_Q9FD69 Cluster: Mevalonate kinase; n=4; Enterococcus|Rep:
Mevalonate kinase - Enterococcus faecalis (Streptococcus
faecalis)
Length = 314
Score = 34.7 bits (76), Expect = 3.0
Identities = 15/21 (71%), Positives = 18/21 (85%)
Frame = +1
Query: 238 APGKVILHGEHSVVYGKTAIA 300
A GK+IL GEH+VVYG+ AIA
Sbjct: 11 ATGKIILMGEHAVVYGEPAIA 31
>UniRef50_Q2BIJ9 Cluster: GHMP kinase; n=1; Neptuniibacter
caesariensis|Rep: GHMP kinase - Neptuniibacter
caesariensis
Length = 309
Score = 34.7 bits (76), Expect = 3.0
Identities = 12/29 (41%), Positives = 22/29 (75%)
Frame = +1
Query: 223 TVSVSAPGKVILHGEHSVVYGKTAIAVSL 309
T+ V PG ++L GEH+V++G+ A+A ++
Sbjct: 3 TIKVKVPGSIMLMGEHAVLFGEKALACAV 31
>UniRef50_Q2GZQ7 Cluster: Putative uncharacterized protein; n=1;
Chaetomium globosum|Rep: Putative uncharacterized
protein - Chaetomium globosum (Soil fungus)
Length = 460
Score = 34.7 bits (76), Expect = 3.0
Identities = 25/73 (34%), Positives = 39/73 (53%), Gaps = 1/73 (1%)
Frame = +1
Query: 223 TVSVSAPGKVILHGEHSVVYGK-TAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQE 399
TV VSAPGKV+L G + V+ K T + L R ++ +E++T + +HL + +Q
Sbjct: 12 TVVVSAPGKVLLAGGYIVLDRKHTGLVFGLSARIHVLAQEIHT----SAGVHLREIVVQS 67
Query: 400 TIPLEPTVKSLFH 438
L T K +H
Sbjct: 68 PQFLNATWKYGYH 80
>UniRef50_Q97UL6 Cluster: (Phospho) mevalonate kinase, putative;
n=4; Sulfolobaceae|Rep: (Phospho) mevalonate kinase,
putative - Sulfolobus solfataricus
Length = 323
Score = 34.7 bits (76), Expect = 3.0
Identities = 14/39 (35%), Positives = 26/39 (66%)
Frame = +1
Query: 226 VSVSAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEV 342
+ VSAPGK++ G +SVV+G + +++ R S ++E+
Sbjct: 2 IKVSAPGKILWIGSYSVVFGGISHVIAVNKRVSCSLREI 40
>UniRef50_Q7XJS3 Cluster: At2g17440 protein; n=3; Brassicaceae|Rep:
At2g17440 protein - Arabidopsis thaliana (Mouse-ear
cress)
Length = 526
Score = 34.3 bits (75), Expect = 3.9
Identities = 17/37 (45%), Positives = 22/37 (59%)
Frame = -2
Query: 770 FPEELFNFNSCINAPARQTAKDAELPVPAPMVSSDPI 660
F E + + CI +P TA +PVPAP+VSSD I
Sbjct: 99 FDELIQRASFCIASPNSTTALPRSVPVPAPVVSSDEI 135
>UniRef50_A3DL21 Cluster: Mevalonate kinase; n=1; Staphylothermus
marinus F1|Rep: Mevalonate kinase - Staphylothermus
marinus (strain ATCC 43588 / DSM 3639 / F1)
Length = 324
Score = 34.3 bits (75), Expect = 3.9
Identities = 17/38 (44%), Positives = 23/38 (60%)
Frame = +1
Query: 235 SAPGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNT 348
+AP KVIL GEH VV K AI ++ L + I E+ +
Sbjct: 5 AAPAKVILFGEHFVVKDKPAIVTAVNLYAKTCITELES 42
>UniRef50_Q38X71 Cluster: Mevalonate kinase; n=1; Lactobacillus
sakei subsp. sakei 23K|Rep: Mevalonate kinase -
Lactobacillus sakei subsp. sakei (strain 23K)
Length = 315
Score = 33.9 bits (74), Expect = 5.2
Identities = 16/42 (38%), Positives = 29/42 (69%), Gaps = 1/42 (2%)
Frame = +1
Query: 247 KVILHGEHSVVYGKTAIAVSL-GLRSSIVIKEVNTPHEPAVH 369
K+IL GEH+VVYG+ AIA+ + +++++ + T EP ++
Sbjct: 11 KIILIGEHAVVYGQPAIALPIFAVQTTVRVTAQPTLSEPLIN 52
>UniRef50_A6GIJ2 Cluster: Putative uncharacterized protein; n=1;
Plesiocystis pacifica SIR-1|Rep: Putative
uncharacterized protein - Plesiocystis pacifica SIR-1
Length = 88
Score = 33.9 bits (74), Expect = 5.2
Identities = 17/46 (36%), Positives = 25/46 (54%)
Frame = +1
Query: 610 SGIFGSTYLPVKSMDISMGSELTIGAGTGSSASFAVCLAGALIQLL 747
+ + G TYL KS + G+ GA TG+ A+ AV L A + +L
Sbjct: 10 TAVGGGTYLYAKSKQATTGTAAVAGAATGAGAAGAVLLVQAALPIL 55
>UniRef50_A5VK03 Cluster: Mevalonate kinase; n=2; Lactobacillus
reuteri|Rep: Mevalonate kinase - Lactobacillus reuteri
F275
Length = 316
Score = 33.9 bits (74), Expect = 5.2
Identities = 15/21 (71%), Positives = 18/21 (85%)
Frame = +1
Query: 247 KVILHGEHSVVYGKTAIAVSL 309
K+IL GEHSVVYG+ AIA+ L
Sbjct: 13 KIILMGEHSVVYGQPAIALPL 33
>UniRef50_A4VT18 Cluster: Mevalonate kinase; n=4; Streptococcus|Rep:
Mevalonate kinase - Streptococcus suis (strain 05ZYH33)
Length = 317
Score = 33.9 bits (74), Expect = 5.2
Identities = 15/22 (68%), Positives = 18/22 (81%)
Frame = +1
Query: 238 APGKVILHGEHSVVYGKTAIAV 303
A GK+IL GEH+VVYG AIA+
Sbjct: 13 ANGKIILMGEHAVVYGHPAIAM 34
>UniRef50_Q8F618 Cluster: Putative uncharacterized protein; n=2;
Leptospira interrogans|Rep: Putative uncharacterized
protein - Leptospira interrogans
Length = 77
Score = 33.5 bits (73), Expect = 6.8
Identities = 19/39 (48%), Positives = 25/39 (64%), Gaps = 1/39 (2%)
Frame = +1
Query: 499 HDYHLRRVEEYLHLIKPN-FDSLPNNQKNSLRSFLYVFS 612
+DYHLR +E +L +K N F S + SL+SFLYV S
Sbjct: 2 YDYHLRVLERFLKNLKGNDFCSFYKLFRFSLQSFLYVMS 40
>UniRef50_Q8H912 Cluster: Putative zinc knuckle domain containing
protein; n=3; Oryza sativa (japonica
cultivar-group)|Rep: Putative zinc knuckle domain
containing protein - Oryza sativa subsp. japonica (Rice)
Length = 910
Score = 33.5 bits (73), Expect = 6.8
Identities = 21/56 (37%), Positives = 26/56 (46%), Gaps = 2/56 (3%)
Frame = +3
Query: 273 GRVRKNCDRCQPRPKELHSDKGS--KHSTRTSSPHTFAVRGSTGDHSIGADSQKSV 434
GR R + D CQ R + HS + S S RT SP + RG G G + K V
Sbjct: 575 GRQRAHGDGCQGRSRTRHSSRCSCRCRSRRTRSPSSLTPRGQDGTGDAGGATTKVV 630
>UniRef50_Q60ED2 Cluster: Putative uncharacterized protein
OSJNBa0002D18.17; n=5; Oryza sativa|Rep: Putative
uncharacterized protein OSJNBa0002D18.17 - Oryza sativa
subsp. japonica (Rice)
Length = 911
Score = 33.5 bits (73), Expect = 6.8
Identities = 13/33 (39%), Positives = 20/33 (60%)
Frame = -3
Query: 412 PMEWSPVDPRTANVCGLLVRVECLLPLSLWSSL 314
P+E V + +N CG LVR CL+ + LW ++
Sbjct: 131 PVEPPIVQSKFSNTCGTLVRTHCLINVKLWETV 163
>UniRef50_Q8SQK4 Cluster: MEVALONATE KINASE; n=1; Encephalitozoon
cuniculi|Rep: MEVALONATE KINASE - Encephalitozoon
cuniculi
Length = 276
Score = 33.5 bits (73), Expect = 6.8
Identities = 18/54 (33%), Positives = 29/54 (53%)
Frame = +1
Query: 238 APGKVILHGEHSVVYGKTAIAVSLGLRSSIVIKEVNTPHEPAVHIHLPCVDLQE 399
+P KVIL GEH V+ G +AV++ + + +K + + + CVDL E
Sbjct: 7 SPLKVILFGEHGVLSGGRCLAVAIDVYGYLAMKSSSINKAIIIDTNGNCVDLIE 60
>UniRef50_UPI0000DB7B87 Cluster: PREDICTED: similar to CG5127-PA
isoform 2; n=1; Apis mellifera|Rep: PREDICTED: similar
to CG5127-PA isoform 2 - Apis mellifera
Length = 554
Score = 33.1 bits (72), Expect = 9.0
Identities = 13/33 (39%), Positives = 20/33 (60%)
Frame = -2
Query: 551 LGLIKCRYSSTLRK**SWSILWGNLQENLPVIP 453
+GL+KCR + L K +WS W N + L ++P
Sbjct: 409 IGLLKCRLENILHKLPNWSSEWNNNAQKLKLLP 441
>UniRef50_Q08UJ8 Cluster: Mevalonate kinase; n=2;
Cystobacterineae|Rep: Mevalonate kinase - Stigmatella
aurantiaca DW4/3-1
Length = 310
Score = 33.1 bits (72), Expect = 9.0
Identities = 15/19 (78%), Positives = 16/19 (84%)
Frame = +1
Query: 244 GKVILHGEHSVVYGKTAIA 300
GKVIL GEHSVVYG A+A
Sbjct: 14 GKVILLGEHSVVYGHPALA 32
>UniRef50_Q031R4 Cluster: Mevalonate kinase; n=3; Lactococcus
lactis|Rep: Mevalonate kinase - Lactococcus lactis
subsp. cremoris (strain SK11)
Length = 310
Score = 33.1 bits (72), Expect = 9.0
Identities = 16/31 (51%), Positives = 22/31 (70%)
Frame = +1
Query: 238 APGKVILHGEHSVVYGKTAIAVSLGLRSSIV 330
A K+IL GEHSVVYG+ AIA+ + + + V
Sbjct: 11 AHSKLILIGEHSVVYGQPAIALPVTILKTTV 41
>UniRef50_Q8ZTT2 Cluster: Mevalonate kinase; n=4; Pyrobaculum|Rep:
Mevalonate kinase - Pyrobaculum aerophilum
Length = 314
Score = 33.1 bits (72), Expect = 9.0
Identities = 14/28 (50%), Positives = 19/28 (67%)
Frame = +1
Query: 226 VSVSAPGKVILHGEHSVVYGKTAIAVSL 309
V + P V L GEH+VVYGK AI+ ++
Sbjct: 2 VKIFVPAAVKLFGEHAVVYGKPAISAAI 29
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 926,621,051
Number of Sequences: 1657284
Number of extensions: 20627605
Number of successful extensions: 57690
Number of sequences better than 10.0: 82
Number of HSP's better than 10.0 without gapping: 54857
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 57660
length of database: 575,637,011
effective HSP length: 100
effective length of database: 409,908,611
effective search space used: 74193458591
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
- SilkBase 1999-2023 -