Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fcaL-P11_F_D10
(816 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P48735 Cluster: Isocitrate dehydrogenase [NADP], mitoch... 338 1e-91
UniRef50_Q8LPJ5 Cluster: Isocitrate dehydrogenase-like protein; ... 318 1e-85
UniRef50_Q9SRZ6 Cluster: F12P19.10 protein; n=26; cellular organ... 297 2e-79
UniRef50_Q0CXI1 Cluster: Isocitrate dehydrogenase, mitochondrial... 283 4e-75
UniRef50_A2WMU2 Cluster: Putative uncharacterized protein; n=5; ... 280 3e-74
UniRef50_A5N5L9 Cluster: Idh; n=2; Bacteria|Rep: Idh - Clostridi... 257 2e-67
UniRef50_A5ZVX5 Cluster: Putative uncharacterized protein; n=1; ... 251 2e-65
UniRef50_UPI0000F1EC8D Cluster: PREDICTED: similar to Isocitrate... 233 3e-60
UniRef50_A2XVE4 Cluster: Putative uncharacterized protein; n=2; ... 103 4e-33
UniRef50_Q00WM7 Cluster: COG0538: Isocitrate dehydrogenases; n=3... 102 1e-20
UniRef50_Q2K7T8 Cluster: NADP-dependent isocitrate dehydrogenase... 101 2e-20
UniRef50_A3JDN6 Cluster: Isocitrate dehydrogenase; n=5; Gammapro... 100 5e-20
UniRef50_Q5DBI8 Cluster: SJCHGC09598 protein; n=1; Schistosoma j... 84 4e-15
UniRef50_A3K670 Cluster: NADP-dependent isocitrate dehydrogenase... 80 8e-14
UniRef50_Q4VCC2 Cluster: Isocitrate dehydrogenase; n=4; Eukaryot... 79 2e-13
UniRef50_A4VDP7 Cluster: Putative uncharacterized protein; n=1; ... 62 2e-08
UniRef50_Q67N12 Cluster: 3-isopropylmalate dehydrogenase; n=5; B... 52 2e-05
UniRef50_Q40658 Cluster: Isocitrate dehydrogenase; n=1; Oryza sa... 42 0.025
UniRef50_Q5E609 Cluster: Putative uncharacterized protein; n=1; ... 35 2.1
UniRef50_A4WT53 Cluster: Sensor protein; n=3; Rhodobacter sphaer... 35 2.8
UniRef50_UPI0000498AD5 Cluster: hypothetical membrane-spanning p... 33 8.6
UniRef50_Q54LD3 Cluster: Putative uncharacterized protein; n=1; ... 33 8.6
>UniRef50_P48735 Cluster: Isocitrate dehydrogenase [NADP],
mitochondrial precursor (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH); n=493;
cellular organisms|Rep: Isocitrate dehydrogenase [NADP],
mitochondrial precursor (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) - Homo
sapiens (Human)
Length = 452
Score = 338 bits (830), Expect = 1e-91
Identities = 153/219 (69%), Positives = 179/219 (81%), Gaps = 1/219 (0%)
Frame = +2
Query: 161 DEMTRIIWDLIKEKLIIPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCAT 340
DEMTRIIW IKEKLI+P +DI+L +DLG+ NRD+TDDQVTID A A +KY+V +KCAT
Sbjct: 56 DEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCAT 115
Query: 341 ITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAH 520
ITPDE RVEEFKLKKMWKSPNGTIRNILGGTVFRE IICKNIPRLV GW KPI IGRHAH
Sbjct: 116 ITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAH 175
Query: 521 ADQYKATDFVVPGAGTLEIIFKPESGEAIKH-VVHEYKGAGVALAMFNTDASIIDFAHSS 697
DQYKATDFV AGT +++F P+ G +K V+ + GV + M+NTD SI FAHS
Sbjct: 176 GDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSC 235
Query: 698 FKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDKEY 814
F++A+ +K+PLY+STKNTILK YDGRFKDIFQ+I+DK Y
Sbjct: 236 FQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHY 274
>UniRef50_Q8LPJ5 Cluster: Isocitrate dehydrogenase-like protein;
n=6; core eudicotyledons|Rep: Isocitrate
dehydrogenase-like protein - Arabidopsis thaliana
(Mouse-ear cress)
Length = 485
Score = 318 bits (781), Expect = 1e-85
Identities = 145/219 (66%), Positives = 178/219 (81%), Gaps = 1/219 (0%)
Frame = +2
Query: 161 DEMTRIIWDLIKEKLIIPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCAT 340
DEMTR+IW +IKEKLI+P+LD+++ +DLG+ NRD TDD+VT++ AEA KYNV IKCAT
Sbjct: 88 DEMTRVIWSMIKEKLILPYLDLDIKYFDLGILNRDATDDKVTVESAEAALKYNVAIKCAT 147
Query: 341 ITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAH 520
ITPDE RV+EF LK MW+SPNGTIRNIL GTVFRE I+C NIPRLV GW+KPI IGRHA
Sbjct: 148 ITPDEGRVKEFGLKSMWRSPNGTIRNILDGTVFREPIMCSNIPRLVPGWEKPICIGRHAF 207
Query: 521 ADQYKATDFVVPGAGTLEIIFKPESGEA-IKHVVHEYKGAGVALAMFNTDASIIDFAHSS 697
DQY+ATD V+ G G L+++F PE G A ++ V+++KG GVALAM+N D SI FA SS
Sbjct: 208 GDQYRATDTVIKGPGKLKMVFVPEDGNAPVELDVYDFKGPGVALAMYNVDESIRAFAESS 267
Query: 698 FKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDKEY 814
AL +K+PLYLSTKNTILKKYDGRFKDIFQ++Y+ +
Sbjct: 268 MAMALTKKWPLYLSTKNTILKKYDGRFKDIFQEVYEANW 306
>UniRef50_Q9SRZ6 Cluster: F12P19.10 protein; n=26; cellular
organisms|Rep: F12P19.10 protein - Arabidopsis thaliana
(Mouse-ear cress)
Length = 410
Score = 297 bits (730), Expect = 2e-79
Identities = 137/218 (62%), Positives = 169/218 (77%)
Frame = +2
Query: 161 DEMTRIIWDLIKEKLIIPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCAT 340
DEMTR+IW IK+KLI PF+++++ +DLG+ +RD TDD+VTI+ AEA KKYNV IKCAT
Sbjct: 18 DEMTRVIWKSIKDKLITPFVELDIKYFDLGLPHRDATDDKVTIESAEATKKYNVAIKCAT 77
Query: 341 ITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAH 520
ITPDE RV EF LK+MW+SPNGTIRNIL GTVFRE IICKN+P+LV GW KPI IGRHA
Sbjct: 78 ITPDEGRVTEFGLKQMWRSPNGTIRNILNGTVFREPIICKNVPKLVPGWTKPICIGRHAF 137
Query: 521 ADQYKATDFVVPGAGTLEIIFKPESGEAIKHVVHEYKGAGVALAMFNTDASIIDFAHSSF 700
DQY+ATD V+ G G L + F+ + G+ V GVA+AM+NTD SI FA +S
Sbjct: 138 GDQYRATDAVIKGPGKLTMTFEGKDGKTETEVFTFTGEGGVAMAMYNTDESIRAFADASM 197
Query: 701 KFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDKEY 814
A ++K+PLYLSTKNTILKKYDGRFKDIFQ++Y+ +
Sbjct: 198 NTAYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEASW 235
>UniRef50_Q0CXI1 Cluster: Isocitrate dehydrogenase, mitochondrial;
n=2; Eurotiomycetidae|Rep: Isocitrate dehydrogenase,
mitochondrial - Aspergillus terreus (strain NIH 2624)
Length = 466
Score = 283 bits (694), Expect = 4e-75
Identities = 131/190 (68%), Positives = 157/190 (82%), Gaps = 1/190 (0%)
Frame = +2
Query: 248 GMENRDKTDDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILG 427
G+E RD+TDD+VT++ AEAIKKY VG+KCATITPDE RVEEFKLKKMW SPNGTIRNILG
Sbjct: 101 GIEYRDQTDDKVTVEAAEAIKKYGVGVKCATITPDEARVEEFKLKKMWLSPNGTIRNILG 160
Query: 428 GTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEAI 607
GTVFRE I+ IPRLV GW KPIIIGRHA DQY+ATD V+PG G LE+++ P +G+
Sbjct: 161 GTVFREPIVIPAIPRLVPGWTKPIIIGRHAFGDQYRATDRVIPGPGKLELVYTPANGQPE 220
Query: 608 KHVVHEYK-GAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKD 784
V++++ G GVA++M+NTD SI FAHSSFK AL + PLY+STKNTILK+YDGRFKD
Sbjct: 221 SVQVYDFQSGGGVAMSMYNTDDSIRGFAHSSFKMALLKGLPLYMSTKNTILKRYDGRFKD 280
Query: 785 IFQDIYDKEY 814
IFQ+IY+ EY
Sbjct: 281 IFQEIYEAEY 290
>UniRef50_A2WMU2 Cluster: Putative uncharacterized protein; n=5;
Eukaryota|Rep: Putative uncharacterized protein - Oryza
sativa subsp. indica (Rice)
Length = 475
Score = 280 bits (687), Expect = 3e-74
Identities = 143/237 (60%), Positives = 169/237 (71%), Gaps = 19/237 (8%)
Frame = +2
Query: 161 DEMTRIIWDLIKEKLIIPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCAT 340
DEMTR+IW IK+KLI PFLD+++ YDLG+ NRD T D+VTI+ AEA KYNV IKCAT
Sbjct: 43 DEMTRVIWKWIKDKLIFPFLDLDIKYYDLGLPNRDATGDKVTIESAEATLKYNVAIKCAT 102
Query: 341 ITP------------------DEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNI 466
ITP DE RV+EF L MWKSPNGTIRNIL GTVFRE IICKNI
Sbjct: 103 ITPVLDTQFKFDFGRTIHEPTDEGRVKEFNLSAMWKSPNGTIRNILNGTVFREPIICKNI 162
Query: 467 PRLVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEAIKHVVHEYKGA-GV 643
PRLV GW KPI IGRHA DQY+ATD V+ G G L+++F E I+ V + GA GV
Sbjct: 163 PRLVPGWIKPICIGRHAFGDQYRATDTVIKGPGKLKLVFDGRE-EQIELDVFNFTGAGGV 221
Query: 644 ALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDKEY 814
AL+M+NTD SI FA +S A +++PLYLSTKNTILKKYDGRFKDIFQ+ Y+ ++
Sbjct: 222 ALSMYNTDESIWAFAEASMNMAYQKRWPLYLSTKNTILKKYDGRFKDIFQENYETKW 278
>UniRef50_A5N5L9 Cluster: Idh; n=2; Bacteria|Rep: Idh - Clostridium
kluyveri DSM 555
Length = 401
Score = 257 bits (630), Expect = 2e-67
Identities = 116/218 (53%), Positives = 154/218 (70%)
Frame = +2
Query: 161 DEMTRIIWDLIKEKLIIPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCAT 340
DEMTRIIW +IKE L+ P++D++ YDLG+ R++T+D++TI+ A AIKKY VG+KCAT
Sbjct: 17 DEMTRIIWKMIKELLLEPYIDLKTEYYDLGLVKRNETNDEITIEAANAIKKYGVGVKCAT 76
Query: 341 ITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAH 520
ITP+ KRV+E+ LK MWKSPNGTIR IL GTVFR II +I L+ W+KPI + RHA+
Sbjct: 77 ITPNAKRVKEYNLKSMWKSPNGTIRAILDGTVFRTPIIVNSIRPLMRTWEKPITVARHAY 136
Query: 521 ADQYKATDFVVPGAGTLEIIFKPESGEAIKHVVHEYKGAGVALAMFNTDASIIDFAHSSF 700
D Y+ ++ V G +E++F E GE + +H + G GV + M N D SI FA S F
Sbjct: 137 GDVYRDVEYKVEEPGKMELVFTSEKGEETRQTLHVFNGPGVVMGMHNLDKSIESFARSCF 196
Query: 701 KFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDKEY 814
+ALD L+ ++K+TI K YD RFKDIFQ+IYD EY
Sbjct: 197 NYALDMNQNLWFASKDTISKTYDHRFKDIFQEIYDTEY 234
>UniRef50_A5ZVX5 Cluster: Putative uncharacterized protein; n=1;
Ruminococcus obeum ATCC 29174|Rep: Putative
uncharacterized protein - Ruminococcus obeum ATCC 29174
Length = 417
Score = 251 bits (614), Expect = 2e-65
Identities = 112/218 (51%), Positives = 152/218 (69%)
Frame = +2
Query: 161 DEMTRIIWDLIKEKLIIPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCAT 340
DEMTRI+W +IK++L++PF+D+ YDLG+ R++TDDQVTID AEA KKY V +KCAT
Sbjct: 31 DEMTRILWKMIKDELLLPFIDLNTEYYDLGLNYRNETDDQVTIDAAEATKKYGVAVKCAT 90
Query: 341 ITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAH 520
ITP+ R++E+ LKKM+KSPNGTIR IL GTVFR I+ K I V W KPI + RHA+
Sbjct: 91 ITPNHARMDEYDLKKMYKSPNGTIRAILDGTVFRAPIVVKGIEPCVRNWKKPITLARHAY 150
Query: 521 ADQYKATDFVVPGAGTLEIIFKPESGEAIKHVVHEYKGAGVALAMFNTDASIIDFAHSSF 700
D YK T+ + G +E+++ E GE + +V E+K GVA+ M N ASI FA S F
Sbjct: 151 GDIYKNTEMYIDKPGKVELVYTSEDGEEKRSLVQEFKAPGVAMGMHNMTASIESFARSCF 210
Query: 701 KFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDKEY 814
+ALD K ++ K+TI K YD +FK++FQ ++D E+
Sbjct: 211 NYALDTKQDVWFGAKDTISKTYDAKFKEVFQTVFDTEF 248
>UniRef50_UPI0000F1EC8D Cluster: PREDICTED: similar to Isocitrate
dehydrogenase 1 (NADP+), soluble; n=2; Danio rerio|Rep:
PREDICTED: similar to Isocitrate dehydrogenase 1
(NADP+), soluble - Danio rerio
Length = 206
Score = 233 bits (571), Expect = 3e-60
Identities = 102/123 (82%), Positives = 116/123 (94%)
Frame = +2
Query: 161 DEMTRIIWDLIKEKLIIPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCAT 340
DEMTR+IW+LIKEKLI P+L+++LH YDLGMENRD TDD+VT++ AEA+++YNVGIKCAT
Sbjct: 23 DEMTRVIWELIKEKLIFPYLELDLHSYDLGMENRDATDDKVTVEAAEAVRRYNVGIKCAT 82
Query: 341 ITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAH 520
ITPDEKRVEEFKLK+MW+SPNGTIRNILGGTVFREAIICKNIPRLV GW KPIIIGRHAH
Sbjct: 83 ITPDEKRVEEFKLKQMWRSPNGTIRNILGGTVFREAIICKNIPRLVPGWIKPIIIGRHAH 142
Query: 521 ADQ 529
DQ
Sbjct: 143 GDQ 145
>UniRef50_A2XVE4 Cluster: Putative uncharacterized protein; n=2;
Oryza sativa|Rep: Putative uncharacterized protein -
Oryza sativa subsp. indica (Rice)
Length = 371
Score = 103 bits (246), Expect(2) = 4e-33
Identities = 46/80 (57%), Positives = 62/80 (77%)
Frame = +2
Query: 575 IIFKPESGEAIKHVVHEYKGAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTI 754
I+ P+ E ++ V+ +KG GVAL+M+N D SI FA SS AL +K+PLYLSTKNTI
Sbjct: 30 ILSVPDGAEPVELNVYNFKGPGVALSMYNVDESIRAFAESSMAMALSKKWPLYLSTKNTI 89
Query: 755 LKKYDGRFKDIFQDIYDKEY 814
LKKYDGRFKDIFQ++Y++++
Sbjct: 90 LKKYDGRFKDIFQEVYEEKW 109
Score = 74.9 bits (176), Expect = 2e-12
Identities = 33/48 (68%), Positives = 41/48 (85%)
Frame = +2
Query: 671 SIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDKEY 814
SI FA SS AL +K+PLYLSTKNTILKKYDGRFKDIFQ++Y++++
Sbjct: 158 SIRAFAESSMAMALSKKWPLYLSTKNTILKKYDGRFKDIFQEVYEEKW 205
Score = 62.1 bits (144), Expect(2) = 4e-33
Identities = 24/32 (75%), Positives = 30/32 (93%)
Frame = +2
Query: 386 MWKSPNGTIRNILGGTVFREAIICKNIPRLVT 481
MW+SPNGTIRNIL GTVFRE I+CKN+PR+++
Sbjct: 1 MWRSPNGTIRNILNGTVFREPILCKNVPRILS 32
>UniRef50_Q00WM7 Cluster: COG0538: Isocitrate dehydrogenases; n=3;
Ostreococcus|Rep: COG0538: Isocitrate dehydrogenases -
Ostreococcus tauri
Length = 429
Score = 102 bits (244), Expect = 1e-20
Identities = 74/225 (32%), Positives = 113/225 (50%), Gaps = 7/225 (3%)
Frame = +2
Query: 161 DEMTRIIWDLIKEKLIIPFLDIE-LHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCA 337
+EMT + DLI+ + I P +D+ +DL +NRD T+D+V D EA K+ K
Sbjct: 37 EEMTAYVMDLIRSRWIEPRVDVGGWETFDLRAKNRDDTEDRVLRDVIEAGKRIKAIFKEP 96
Query: 338 TITPDEKRVEEFKLKKMWKSPNGTIRNILGG-TVFREAIICKNIPRLVTGWDKPIIIGRH 514
T+TP +V+ L+K W SPNG +R G T+ R+ I +I + G+ KP++ RH
Sbjct: 97 TVTPTADQVKRLGLRKSWGSPNGAMRRGWNGITISRDTI---HIDGVELGYKKPVLFERH 153
Query: 515 AHADQYKATDFVVPGAGTLEIIFKPESG-EAIKHVV---HEYKGAGVALAMF-NTDASII 679
A +Y A + G G L F P G +A K VV E A+ + N ++
Sbjct: 154 AVGGEYSA-GYKNVGKGKLTTTFTPSEGPDAGKTVVVDEREIVDEEAAVVTYHNPYDNVH 212
Query: 680 DFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDKEY 814
D A F L+ K Y+ TK T+ K+ F I + ++D+E+
Sbjct: 213 DLARFFFGRCLEAKVTPYVVTKKTVF-KWQEPFWQIMRTVFDEEF 256
>UniRef50_Q2K7T8 Cluster: NADP-dependent isocitrate dehydrogenase
protein; n=1; Rhizobium etli CFN 42|Rep: NADP-dependent
isocitrate dehydrogenase protein - Rhizobium etli
(strain CFN 42 / ATCC 51251)
Length = 437
Score = 101 bits (243), Expect = 2e-20
Identities = 61/215 (28%), Positives = 112/215 (52%)
Frame = -3
Query: 805 VINILKDVFETTIVFLEDCILSA*VQRVFSVQSKLE*RMSKVNNRCISVKHSQCYTCTLV 626
+++ L+DV E ++ LED +L V R F+ Q+ + +R + V H
Sbjct: 193 LVDFLEDVLEAAVIGLEDGVLGRQVDRPFAHQAVHHRGAGEFADRFVEVVHGHGNAGARR 252
Query: 625 LMNYMFYCLTRFRFEDYFKSTSTWDNKVSCFVLISMSMTSNDDGFVPPCYKSRYILANNS 446
+ + + F E + + +V C VL++ S+T++DD P ++R + A++
Sbjct: 253 VEDLLLDDGAVFTDELDRQLALAGELEVGCAVLVAESVTADDDRLRPAGNEARNVAADDR 312
Query: 445 LPENSTTKNITDGPIRAFPHFLQFKFFNSLLIRSYGRTFDAHIVFLYGLSTINCNLIISL 266
L E+ +N++D +RA PHFL+ +F ++ IR D VFL G+ ++ +L++
Sbjct: 313 LAEDDAAENVSDRAVRALPHFLEIEFLDAGFIRRDRCALDTDAVFLDGVGGVDRHLVVGG 372
Query: 265 ITIFHTQVVDM*FNVQERNNQLFFDKIPDYSGHFI 161
+ IF +VV + V+ R +QL D++PD + HFI
Sbjct: 373 VAIFDREVVIVDIEVEIRMDQLILDELPDDACHFI 407
>UniRef50_A3JDN6 Cluster: Isocitrate dehydrogenase; n=5;
Gammaproteobacteria|Rep: Isocitrate dehydrogenase -
Marinobacter sp. ELB17
Length = 582
Score = 100 bits (239), Expect = 5e-20
Identities = 68/230 (29%), Positives = 115/230 (50%), Gaps = 12/230 (5%)
Frame = +2
Query: 161 DEMTRIIWDLIKEKLIIPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCAT 340
DEM ++ ++ I +K + L IEL DL E+R T+ QV + EA+KKY VG+K A
Sbjct: 17 DEMAQVAFEEILKKFVTTRLAIELIEIDLSAEHRFLTNGQVIFEAIEALKKYGVGVKNAG 76
Query: 341 ITPDEKRVE-------EFKLKKM----WKSPNGTIRNILGGTVFREAIICKNIPRLVTGW 487
+T + ++++ E ++ KSPNG IR +GG + RE I +N+ W
Sbjct: 77 MTVNREQLDAMLEKHPELSQSRLDPLATKSPNGAIRKGIGGNITREDIQFQNLRVRKPDW 136
Query: 488 -DKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEAIKHVVHEYKGAGVALAMFNT 664
D+ I + + + + + G ++++F +SG ++ + K L N
Sbjct: 137 IDRDIDVDTMDNGGIKDSYNELSSSTGVVKLLFVGKSGNPVELHRRDVKKGDPWLLATND 196
Query: 665 DASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDKEY 814
A + +AH F+ A+D K YL K+T++ YDG + + IY +EY
Sbjct: 197 IADVKAWAHRFFQRAIDEKRDAYLGLKDTVIAGYDGVMRAAIEAIYKQEY 246
>UniRef50_Q5DBI8 Cluster: SJCHGC09598 protein; n=1; Schistosoma
japonicum|Rep: SJCHGC09598 protein - Schistosoma
japonicum (Blood fluke)
Length = 129
Score = 84.2 bits (199), Expect = 4e-15
Identities = 51/91 (56%), Positives = 55/91 (60%)
Frame = -1
Query: 450 IASLKTVPPRILRMVPLGLFHIXXXXXXXXXXXSGVMVAHLMPTLYFFMASAQSIVT*SS 271
+ S KTVPPRILR+VP G HI SGVMVAHL+PTLYF +ASA SIVT S
Sbjct: 1 MGSRKTVPPRILRIVPFGDSHIFFKLNSLTRCSSGVMVAHLIPTLYFLIASAPSIVTWSL 60
Query: 270 VLSRFSIPKS*TCNSMSKKGIISFSLIRSQI 178
V SR PKS S S G IS IRS I
Sbjct: 61 VRSRLGRPKSKYLQSTSINGNISCCFIRSII 91
>UniRef50_A3K670 Cluster: NADP-dependent isocitrate dehydrogenase
protein; n=2; Rhodobacteraceae|Rep: NADP-dependent
isocitrate dehydrogenase protein - Sagittula stellata
E-37
Length = 459
Score = 79.8 bits (188), Expect = 8e-14
Identities = 50/217 (23%), Positives = 107/217 (49%)
Frame = -3
Query: 811 LLVINILKDVFETTIVFLEDCILSA*VQRVFSVQSKLE*RMSKVNNRCISVKHSQCYTCT 632
L ++++L+ V E +V LE+ +L V R Q+ ++ KV +R + V H+
Sbjct: 222 LRLVDLLEQVLEPPVVGLENGVLGRQVHRPAQRQTVVQRGAGKVADRLVLVVHAHVDPGI 281
Query: 631 LVLMNYMFYCLTRFRFEDYFKSTSTWDNKVSCFVLISMSMTSNDDGFVPPCYKSRYILAN 452
+++ L F + + + ++ VL++ + ++ DG P +++R++ A+
Sbjct: 282 GRVVDLALDHLAVGAFPFHRQLARRGEVEIRGLVLVAEGVPAHHDGRGPARHEARHVAAD 341
Query: 451 NSLPENSTTKNITDGPIRAFPHFLQFKFFNSLLIRSYGRTFDAHIVFLYGLSTINCNLII 272
+ L E+ +++ D + PH L+ +F ++LL+R R FD L ++ +L+
Sbjct: 342 DRLAEDDAAQDVADRAVGRLPHLLETEFLDTLLVRGDRRAFDRDANLLRLFGGVDGDLVP 401
Query: 271 SLITIFHTQVVDM*FNVQERNNQLFFDKIPDYSGHFI 161
+ + ++V V+ R +QLF D+ P +GH +
Sbjct: 402 GPVPLLDPEIVVKQVQVEVRQDQLFLDESPHDAGHLV 438
>UniRef50_Q4VCC2 Cluster: Isocitrate dehydrogenase; n=4;
Eukaryota|Rep: Isocitrate dehydrogenase - Saltugilia
latimeri
Length = 158
Score = 78.6 bits (185), Expect = 2e-13
Identities = 34/51 (66%), Positives = 42/51 (82%)
Frame = +2
Query: 662 TDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDKEY 814
TD SI FA +S A ++K+PLYLSTKNTILKKYDGRFKDIFQ++Y+K +
Sbjct: 1 TDESIYSFAEASMTTAYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEKSW 51
>UniRef50_A4VDP7 Cluster: Putative uncharacterized protein; n=1;
Tetrahymena thermophila SB210|Rep: Putative
uncharacterized protein - Tetrahymena thermophila SB210
Length = 141
Score = 61.7 bits (143), Expect = 2e-08
Identities = 42/87 (48%), Positives = 50/87 (57%)
Frame = -1
Query: 420 ILRMVPLGLFHIXXXXXXXXXXXSGVMVAHLMPTLYFFMASAQSIVT*SSVLSRFSIPKS 241
+LR+VPLG HI S V+VAHL+PTL +A A S VT S V SRFSI +S
Sbjct: 1 MLRIVPLGEGHIFLSLNSLTRASSAVIVAHLIPTLCSRIAQAASKVTQSLVASRFSIERS 60
Query: 240 *TCNSMSKKGIISFSLIRSQIILVISS 160
S G +S SLI Q+I VISS
Sbjct: 61 QYLISAEINGNMSLSLIIFQMIRVISS 87
>UniRef50_Q67N12 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Symbiobacterium thermophilum
Length = 357
Score = 51.6 bits (118), Expect = 2e-05
Identities = 46/141 (32%), Positives = 74/141 (52%), Gaps = 7/141 (4%)
Frame = +2
Query: 185 DLIKE--KLIIP-FLDIELHV--YDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCATITP 349
+L++E +L+ P + + LH+ YDL +ENR T ++V + A A++++ G+K ATITP
Sbjct: 18 ELLEEAVRLLSPDVIGLPLHLVRYDLSLENRRATSNRVVYEAAAAMREHGYGLKAATITP 77
Query: 350 DEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVT--GWDKPIIIGRHAHA 523
E R + SPN +R + GTV + +P + T G PI + R A
Sbjct: 78 -EGRGDV-------GSPNAILRREIDGTVILRT--GRPLPGVETIGGITAPIAVVRMATE 127
Query: 524 DQYKATDFVVPGAGTLEIIFK 586
D Y+A ++ G G E F+
Sbjct: 128 DAYEAKEW-REGEGDEERAFR 147
>UniRef50_Q40658 Cluster: Isocitrate dehydrogenase; n=1; Oryza
sativa|Rep: Isocitrate dehydrogenase - Oryza sativa
(Rice)
Length = 61
Score = 41.5 bits (93), Expect = 0.025
Identities = 16/25 (64%), Positives = 21/25 (84%)
Frame = +2
Query: 161 DEMTRIIWDLIKEKLIIPFLDIELH 235
DEMTRI W IK+KLI PFLD++++
Sbjct: 37 DEMTRIFWQSIKDKLIFPFLDLDIN 61
>UniRef50_Q5E609 Cluster: Putative uncharacterized protein; n=1;
Vibrio fischeri ES114|Rep: Putative uncharacterized
protein - Vibrio fischeri (strain ATCC 700601 / ES114)
Length = 326
Score = 35.1 bits (77), Expect = 2.1
Identities = 16/46 (34%), Positives = 24/46 (52%), Gaps = 2/46 (4%)
Frame = +2
Query: 239 YDLGMENRDKTDDQVTIDCA--EAIKKYNVGIKCATITPDEKRVEE 370
+ G + DK + +DC+ KYN+ +KCAT + DEK E
Sbjct: 86 FSQGFKYEDKVNPPKDVDCSVYHDYAKYNIEVKCATFSDDEKLKSE 131
>UniRef50_A4WT53 Cluster: Sensor protein; n=3; Rhodobacter
sphaeroides|Rep: Sensor protein - Rhodobacter
sphaeroides ATCC 17025
Length = 890
Score = 34.7 bits (76), Expect = 2.8
Identities = 17/49 (34%), Positives = 28/49 (57%)
Frame = +2
Query: 500 IIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEAIKHVVHEYKGAGVA 646
I+G AHAD + +F+ GAG +++ KP + A+ V ++ G G A
Sbjct: 716 IVGATAHADPDRVPEFL--GAGMNDVLVKPITRSALFRAVRQFAGCGQA 762
>UniRef50_UPI0000498AD5 Cluster: hypothetical membrane-spanning
protein; n=1; Entamoeba histolytica HM-1:IMSS|Rep:
hypothetical membrane-spanning protein - Entamoeba
histolytica HM-1:IMSS
Length = 453
Score = 33.1 bits (72), Expect = 8.6
Identities = 30/127 (23%), Positives = 57/127 (44%), Gaps = 3/127 (2%)
Frame = -3
Query: 628 VLMNYMFYCLTRFRFEDYFKSTSTWDNKVSCF--VLISMSMTSNDDGFVP-PCYKSRYIL 458
+L N +F + Y KS+S V+ ++ ++ + F+ P Y R +L
Sbjct: 24 LLKNDIFGYEKEIHYPIYKKSSSPIQQSVNLTQQIVNENTIPQSVKSFIQTPFYLERSVL 83
Query: 457 ANNSLPENSTTKNITDGPIRAFPHFLQFKFFNSLLIRSYGRTFDAHIVFLYGLSTINCNL 278
+ ++ + + P+R +F Q F N ++ Y R +D + +Y LST+ C +
Sbjct: 84 IGLLISWDTFSSFLLFTPLRIISYFYQLIFLNEKVVIHYKRIYD---ILMY-LSTLFCVI 139
Query: 277 IISLITI 257
II + I
Sbjct: 140 IIYQVDI 146
>UniRef50_Q54LD3 Cluster: Putative uncharacterized protein; n=1;
Dictyostelium discoideum AX4|Rep: Putative
uncharacterized protein - Dictyostelium discoideum AX4
Length = 1137
Score = 33.1 bits (72), Expect = 8.6
Identities = 25/91 (27%), Positives = 43/91 (47%), Gaps = 3/91 (3%)
Frame = -3
Query: 436 NSTTKNITDGPIRAFPHFLQFKFFNSLLIRSYGRTFDAHIVFLY-GLSTINCNLI--ISL 266
N+ T P+R FPH S+LI+ Y D + +F + +S+I +I + L
Sbjct: 933 NTNTFIAATSPLRNFPHLFNQIQLTSILIKKYQNQNDIYPIFNWNNISSIGNEVIKTLDL 992
Query: 265 ITIFHTQVVDM*FNVQERNNQLFFDKIPDYS 173
F +++VD F +Q N + +I + S
Sbjct: 993 KQAFESKLVDY-FVLQSINKDISSQRIKNSS 1022
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 784,262,753
Number of Sequences: 1657284
Number of extensions: 16143933
Number of successful extensions: 40637
Number of sequences better than 10.0: 22
Number of HSP's better than 10.0 without gapping: 39012
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 40619
length of database: 575,637,011
effective HSP length: 99
effective length of database: 411,565,895
effective search space used: 70789333940
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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