Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fcaL-P09_pT_B13
(786 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
BC063302-1|AAH63302.1| 1278|Homo sapiens Niemann-Pick disease, t... 179 9e-45
AF338230-1|AAK25791.1| 1278|Homo sapiens Niemann-Pick disease C1... 179 9e-45
AF157379-1|AAD48006.1| 1278|Homo sapiens Niemann-Pick C1 protein... 179 9e-45
AF002020-1|AAB63982.1| 1278|Homo sapiens Niemann-Pick C disease ... 179 9e-45
AB209048-1|BAD92285.1| 1289|Homo sapiens Niemann-Pick disease, t... 179 9e-45
BC117178-1|AAI17179.1| 1332|Homo sapiens NPC1L1 protein protein. 136 8e-32
AY515256-1|AAS56939.1| 1332|Homo sapiens NPC1L1 splice variant p... 136 8e-32
AY437865-1|AAR97886.1| 1332|Homo sapiens Niemann-Pick C1-like 1 ... 136 8e-32
AF192522-1|AAF20396.1| 1359|Homo sapiens Niemann-Pick C1-like pr... 136 8e-32
AF123046-1|AAF28875.1| 190|Homo sapiens Niemann-Pick C1 disease... 135 1e-31
AY438664-1|AAR05447.1| 1203|Homo sapiens patched homolog 2 (Dros... 63 1e-09
AY359016-1|AAQ89375.1| 1203|Homo sapiens Patched 2 protein. 63 1e-09
AY358555-1|AAQ88919.1| 1211|Homo sapiens Patched 2 protein. 63 1e-09
AL592166-5|CAI13000.1| 1203|Homo sapiens patched homolog 2 (Dros... 63 1e-09
AL136380-1|CAI23127.1| 1203|Homo sapiens patched homolog 2 (Dros... 63 1e-09
AF119569-1|AAD17260.1| 1146|Homo sapiens patched 2 protein. 63 1e-09
AF091501-1|AAC79847.1| 1203|Homo sapiens receptor protein patche... 63 1e-09
AF087651-1|AAD25953.1| 1203|Homo sapiens patched 2 protein. 63 1e-09
U59464-1|AAC50550.1| 1447|Homo sapiens PATCHED protein. 61 4e-09
AL161729-2|CAH73818.1| 1296|Homo sapiens patched homolog 1 (Dros... 61 4e-09
AL161729-1|CAH73817.1| 1447|Homo sapiens patched homolog 1 (Dros... 61 4e-09
U43148-1|AAC50496.1| 1296|Homo sapiens PTC protein. 58 3e-08
AL161622-2|CAI20456.1| 510|Homo sapiens protein ( vel protein s... 46 2e-04
AY395772-1|AAR21240.1| 345|Homo sapiens patched protein. 39 0.018
AL590989-2|CAH70606.1| 1438|Homo sapiens patched domain containi... 39 0.018
AL031735-1|CAI22474.1| 1438|Homo sapiens patched domain containi... 39 0.018
AB037758-1|BAA92575.1| 1438|Homo sapiens KIAA1337 protein protein. 39 0.018
AB209495-1|BAD92732.1| 586|Homo sapiens patched variant protein. 38 0.031
AL592166-13|CAI13008.1| 87|Homo sapiens patched homolog 2 (Dro... 34 0.51
CR457373-1|CAG33654.1| 204|Homo sapiens NIF3L1BP1 protein. 33 1.5
BC065012-1|AAH65012.1| 204|Homo sapiens THO complex 7 homolog (... 33 1.5
BC020599-1|AAH20599.2| 197|Homo sapiens THOC7 protein protein. 33 1.5
AK027098-1|BAB15656.1| 204|Homo sapiens protein ( Homo sapiens ... 33 1.5
BC011542-1|AAH11542.2| 1011|Homo sapiens DISP1 protein protein. 32 2.7
AK026114-1|BAB15365.1| 917|Homo sapiens protein ( Homo sapiens ... 32 2.7
AK023679-1|BAB14637.1| 637|Homo sapiens protein ( Homo sapiens ... 32 2.7
>BC063302-1|AAH63302.1| 1278|Homo sapiens Niemann-Pick disease, type
C1 protein.
Length = 1278
Score = 179 bits (436), Expect = 9e-45
Identities = 88/135 (65%), Positives = 103/135 (76%), Gaps = 2/135 (1%)
Frame = -1
Query: 744 NLGGLMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSFSVSXXXXXXXXXADALLRMGS 565
N+ G+M+ WGISLNAVSLVNLVM+ GISVEFCSH+ +F+VS +AL MGS
Sbjct: 1137 NMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGS 1196
Query: 564 SVLSGITLTKFGGIIVLATAKSQIFQVFYFRMYLGIVLFGAAHGLVFLPVMLSYIGSPVN 385
SV SGITLTKFGGI+VLA AKSQIFQ+FYFRMYL +VL GA HGL+FLPV+LSYIG VN
Sbjct: 1197 SVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVN 1256
Query: 384 KQK--LANQRRRGNE 346
K K +R +G E
Sbjct: 1257 KAKSCATEERYKGTE 1271
>AF338230-1|AAK25791.1| 1278|Homo sapiens Niemann-Pick disease C1
protein protein.
Length = 1278
Score = 179 bits (436), Expect = 9e-45
Identities = 88/135 (65%), Positives = 103/135 (76%), Gaps = 2/135 (1%)
Frame = -1
Query: 744 NLGGLMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSFSVSXXXXXXXXXADALLRMGS 565
N+ G+M+ WGISLNAVSLVNLVM+ GISVEFCSH+ +F+VS +AL MGS
Sbjct: 1137 NMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGS 1196
Query: 564 SVLSGITLTKFGGIIVLATAKSQIFQVFYFRMYLGIVLFGAAHGLVFLPVMLSYIGSPVN 385
SV SGITLTKFGGI+VLA AKSQIFQ+FYFRMYL +VL GA HGL+FLPV+LSYIG VN
Sbjct: 1197 SVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVN 1256
Query: 384 KQK--LANQRRRGNE 346
K K +R +G E
Sbjct: 1257 KAKSCATEERYKGTE 1271
>AF157379-1|AAD48006.1| 1278|Homo sapiens Niemann-Pick C1 protein
protein.
Length = 1278
Score = 179 bits (436), Expect = 9e-45
Identities = 88/135 (65%), Positives = 103/135 (76%), Gaps = 2/135 (1%)
Frame = -1
Query: 744 NLGGLMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSFSVSXXXXXXXXXADALLRMGS 565
N+ G+M+ WGISLNAVSLVNLVM+ GISVEFCSH+ +F+VS +AL MGS
Sbjct: 1137 NMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGS 1196
Query: 564 SVLSGITLTKFGGIIVLATAKSQIFQVFYFRMYLGIVLFGAAHGLVFLPVMLSYIGSPVN 385
SV SGITLTKFGGI+VLA AKSQIFQ+FYFRMYL +VL GA HGL+FLPV+LSYIG VN
Sbjct: 1197 SVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVN 1256
Query: 384 KQK--LANQRRRGNE 346
K K +R +G E
Sbjct: 1257 KAKSCATEERYKGTE 1271
>AF002020-1|AAB63982.1| 1278|Homo sapiens Niemann-Pick C disease
protein protein.
Length = 1278
Score = 179 bits (436), Expect = 9e-45
Identities = 88/135 (65%), Positives = 103/135 (76%), Gaps = 2/135 (1%)
Frame = -1
Query: 744 NLGGLMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSFSVSXXXXXXXXXADALLRMGS 565
N+ G+M+ WGISLNAVSLVNLVM+ GISVEFCSH+ +F+VS +AL MGS
Sbjct: 1137 NMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGS 1196
Query: 564 SVLSGITLTKFGGIIVLATAKSQIFQVFYFRMYLGIVLFGAAHGLVFLPVMLSYIGSPVN 385
SV SGITLTKFGGI+VLA AKSQIFQ+FYFRMYL +VL GA HGL+FLPV+LSYIG VN
Sbjct: 1197 SVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVN 1256
Query: 384 KQK--LANQRRRGNE 346
K K +R +G E
Sbjct: 1257 KAKSCATEERYKGTE 1271
>AB209048-1|BAD92285.1| 1289|Homo sapiens Niemann-Pick disease, type
C1 variant protein.
Length = 1289
Score = 179 bits (436), Expect = 9e-45
Identities = 88/135 (65%), Positives = 103/135 (76%), Gaps = 2/135 (1%)
Frame = -1
Query: 744 NLGGLMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSFSVSXXXXXXXXXADALLRMGS 565
N+ G+M+ WGISLNAVSLVNLVM+ GISVEFCSH+ +F+VS +AL MGS
Sbjct: 1148 NMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGS 1207
Query: 564 SVLSGITLTKFGGIIVLATAKSQIFQVFYFRMYLGIVLFGAAHGLVFLPVMLSYIGSPVN 385
SV SGITLTKFGGI+VLA AKSQIFQ+FYFRMYL +VL GA HGL+FLPV+LSYIG VN
Sbjct: 1208 SVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVN 1267
Query: 384 KQK--LANQRRRGNE 346
K K +R +G E
Sbjct: 1268 KAKSCATEERYKGTE 1282
>BC117178-1|AAI17179.1| 1332|Homo sapiens NPC1L1 protein protein.
Length = 1332
Score = 136 bits (329), Expect = 8e-32
Identities = 67/134 (50%), Positives = 89/134 (66%)
Frame = -1
Query: 735 GLMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSFSVSXXXXXXXXXADALLRMGSSVL 556
G M WGIS NAVSL+NLV AVG+SVEF SH+ SF++S +A + MGS+V
Sbjct: 1154 GFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVF 1213
Query: 555 SGITLTKFGGIIVLATAKSQIFQVFYFRMYLGIVLFGAAHGLVFLPVMLSYIGSPVNKQK 376
+G+ +T GI+VL AK+Q+ Q+F+FR+ L I L G HGLVFLPV+LSY+G VN
Sbjct: 1214 AGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGPDVN-PA 1272
Query: 375 LANQRRRGNETTVA 334
LA +++R E A
Sbjct: 1273 LALEQKRAEEAVAA 1286
>AY515256-1|AAS56939.1| 1332|Homo sapiens NPC1L1 splice variant
protein.
Length = 1332
Score = 136 bits (329), Expect = 8e-32
Identities = 67/134 (50%), Positives = 89/134 (66%)
Frame = -1
Query: 735 GLMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSFSVSXXXXXXXXXADALLRMGSSVL 556
G M WGIS NAVSL+NLV AVG+SVEF SH+ SF++S +A + MGS+V
Sbjct: 1154 GFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVF 1213
Query: 555 SGITLTKFGGIIVLATAKSQIFQVFYFRMYLGIVLFGAAHGLVFLPVMLSYIGSPVNKQK 376
+G+ +T GI+VL AK+Q+ Q+F+FR+ L I L G HGLVFLPV+LSY+G VN
Sbjct: 1214 AGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGPDVN-PA 1272
Query: 375 LANQRRRGNETTVA 334
LA +++R E A
Sbjct: 1273 LALEQKRAEEAVAA 1286
>AY437865-1|AAR97886.1| 1332|Homo sapiens Niemann-Pick C1-like 1
protein.
Length = 1332
Score = 136 bits (329), Expect = 8e-32
Identities = 67/134 (50%), Positives = 89/134 (66%)
Frame = -1
Query: 735 GLMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSFSVSXXXXXXXXXADALLRMGSSVL 556
G M WGIS NAVSL+NLV AVG+SVEF SH+ SF++S +A + MGS+V
Sbjct: 1154 GFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVF 1213
Query: 555 SGITLTKFGGIIVLATAKSQIFQVFYFRMYLGIVLFGAAHGLVFLPVMLSYIGSPVNKQK 376
+G+ +T GI+VL AK+Q+ Q+F+FR+ L I L G HGLVFLPV+LSY+G VN
Sbjct: 1214 AGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGPDVN-PA 1272
Query: 375 LANQRRRGNETTVA 334
LA +++R E A
Sbjct: 1273 LALEQKRAEEAVAA 1286
>AF192522-1|AAF20396.1| 1359|Homo sapiens Niemann-Pick C1-like protein
1 protein.
Length = 1359
Score = 136 bits (329), Expect = 8e-32
Identities = 67/134 (50%), Positives = 89/134 (66%)
Frame = -1
Query: 735 GLMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSFSVSXXXXXXXXXADALLRMGSSVL 556
G M WGIS NAVSL+NLV AVG+SVEF SH+ SF++S +A + MGS+V
Sbjct: 1181 GFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVF 1240
Query: 555 SGITLTKFGGIIVLATAKSQIFQVFYFRMYLGIVLFGAAHGLVFLPVMLSYIGSPVNKQK 376
+G+ +T GI+VL AK+Q+ Q+F+FR+ L I L G HGLVFLPV+LSY+G VN
Sbjct: 1241 AGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGPDVN-PA 1299
Query: 375 LANQRRRGNETTVA 334
LA +++R E A
Sbjct: 1300 LALEQKRAEEAVAA 1313
>AF123046-1|AAF28875.1| 190|Homo sapiens Niemann-Pick C1 disease
protein protein.
Length = 190
Score = 135 bits (327), Expect = 1e-31
Identities = 65/94 (69%), Positives = 75/94 (79%)
Frame = -1
Query: 744 NLGGLMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSFSVSXXXXXXXXXADALLRMGS 565
N+ G+M+ WGISLNAVSLVNLVM+ GISVEFCSH+ +F+VS +AL MGS
Sbjct: 96 NMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGS 155
Query: 564 SVLSGITLTKFGGIIVLATAKSQIFQVFYFRMYL 463
SV SGITLTKFGGI+VLA AKSQIFQ+FYFRMYL
Sbjct: 156 SVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYL 189
>AY438664-1|AAR05447.1| 1203|Homo sapiens patched homolog 2
(Drosophila) protein.
Length = 1203
Score = 62.9 bits (146), Expect = 1e-09
Identities = 41/117 (35%), Positives = 60/117 (51%)
Frame = -1
Query: 741 LGGLMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSFSVSXXXXXXXXXADALLRMGSS 562
L G+M + GI L+A+ +V LV +VGI VEF H+ F ++ A AL +
Sbjct: 1003 LFGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGF-LTTQGSRNLRAAHALEHTFAP 1061
Query: 561 VLSGITLTKFGGIIVLATAKSQIFQVFYFRMYLGIVLFGAAHGLVFLPVMLSYIGSP 391
V G T G +++LA + ++F + L G HGLV LPV+LS +G P
Sbjct: 1062 VTDGAISTLLG-LLMLAGSHFDFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGPP 1117
>AY359016-1|AAQ89375.1| 1203|Homo sapiens Patched 2 protein.
Length = 1203
Score = 62.9 bits (146), Expect = 1e-09
Identities = 41/117 (35%), Positives = 60/117 (51%)
Frame = -1
Query: 741 LGGLMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSFSVSXXXXXXXXXADALLRMGSS 562
L G+M + GI L+A+ +V LV +VGI VEF H+ F ++ A AL +
Sbjct: 1003 LFGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGF-LTTQGSRNLRAAHALEHTFAP 1061
Query: 561 VLSGITLTKFGGIIVLATAKSQIFQVFYFRMYLGIVLFGAAHGLVFLPVMLSYIGSP 391
V G T G +++LA + ++F + L G HGLV LPV+LS +G P
Sbjct: 1062 VTDGAISTLLG-LLMLAGSHFDFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGPP 1117
>AY358555-1|AAQ88919.1| 1211|Homo sapiens Patched 2 protein.
Length = 1211
Score = 62.9 bits (146), Expect = 1e-09
Identities = 41/117 (35%), Positives = 60/117 (51%)
Frame = -1
Query: 741 LGGLMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSFSVSXXXXXXXXXADALLRMGSS 562
L G+M + GI L+A+ +V LV +VGI VEF H+ F ++ A AL +
Sbjct: 1003 LFGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGF-LTTQGSRNLRAAHALEHTFAP 1061
Query: 561 VLSGITLTKFGGIIVLATAKSQIFQVFYFRMYLGIVLFGAAHGLVFLPVMLSYIGSP 391
V G T G +++LA + ++F + L G HGLV LPV+LS +G P
Sbjct: 1062 VTDGAISTLLG-LLMLAGSHFDFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGPP 1117
>AL592166-5|CAI13000.1| 1203|Homo sapiens patched homolog 2
(Drosophila) protein.
Length = 1203
Score = 62.9 bits (146), Expect = 1e-09
Identities = 41/117 (35%), Positives = 60/117 (51%)
Frame = -1
Query: 741 LGGLMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSFSVSXXXXXXXXXADALLRMGSS 562
L G+M + GI L+A+ +V LV +VGI VEF H+ F ++ A AL +
Sbjct: 1003 LFGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGF-LTTQGSRNLRAAHALEHTFAP 1061
Query: 561 VLSGITLTKFGGIIVLATAKSQIFQVFYFRMYLGIVLFGAAHGLVFLPVMLSYIGSP 391
V G T G +++LA + ++F + L G HGLV LPV+LS +G P
Sbjct: 1062 VTDGAISTLLG-LLMLAGSHFDFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGPP 1117
>AL136380-1|CAI23127.1| 1203|Homo sapiens patched homolog 2
(Drosophila) protein.
Length = 1203
Score = 62.9 bits (146), Expect = 1e-09
Identities = 41/117 (35%), Positives = 60/117 (51%)
Frame = -1
Query: 741 LGGLMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSFSVSXXXXXXXXXADALLRMGSS 562
L G+M + GI L+A+ +V LV +VGI VEF H+ F ++ A AL +
Sbjct: 1003 LFGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGF-LTTQGSRNLRAAHALEHTFAP 1061
Query: 561 VLSGITLTKFGGIIVLATAKSQIFQVFYFRMYLGIVLFGAAHGLVFLPVMLSYIGSP 391
V G T G +++LA + ++F + L G HGLV LPV+LS +G P
Sbjct: 1062 VTDGAISTLLG-LLMLAGSHFDFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGPP 1117
>AF119569-1|AAD17260.1| 1146|Homo sapiens patched 2 protein.
Length = 1146
Score = 62.9 bits (146), Expect = 1e-09
Identities = 41/117 (35%), Positives = 60/117 (51%)
Frame = -1
Query: 741 LGGLMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSFSVSXXXXXXXXXADALLRMGSS 562
L G+M + GI L+A+ +V LV +VGI VEF H+ F ++ A AL +
Sbjct: 1003 LFGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGF-LTTQGSRNLRAAHALEHTFAP 1061
Query: 561 VLSGITLTKFGGIIVLATAKSQIFQVFYFRMYLGIVLFGAAHGLVFLPVMLSYIGSP 391
V G T G +++LA + ++F + L G HGLV LPV+LS +G P
Sbjct: 1062 VTDGAISTLLG-LLMLAGSHFDFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGPP 1117
>AF091501-1|AAC79847.1| 1203|Homo sapiens receptor protein patched 2
protein.
Length = 1203
Score = 62.9 bits (146), Expect = 1e-09
Identities = 41/117 (35%), Positives = 60/117 (51%)
Frame = -1
Query: 741 LGGLMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSFSVSXXXXXXXXXADALLRMGSS 562
L G+M + GI L+A+ +V LV +VGI VEF H+ F ++ A AL +
Sbjct: 1003 LFGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGF-LTTQGSRNLRAAHALEHTFAP 1061
Query: 561 VLSGITLTKFGGIIVLATAKSQIFQVFYFRMYLGIVLFGAAHGLVFLPVMLSYIGSP 391
V G T G +++LA + ++F + L G HGLV LPV+LS +G P
Sbjct: 1062 VTDGAISTLLG-LLMLAGSHFDFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGPP 1117
>AF087651-1|AAD25953.1| 1203|Homo sapiens patched 2 protein.
Length = 1203
Score = 62.9 bits (146), Expect = 1e-09
Identities = 41/117 (35%), Positives = 60/117 (51%)
Frame = -1
Query: 741 LGGLMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSFSVSXXXXXXXXXADALLRMGSS 562
L G+M + GI L+A+ +V LV +VGI VEF H+ F ++ A AL +
Sbjct: 1003 LFGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGF-LTTQGSRNLRAAHALEHTFAP 1061
Query: 561 VLSGITLTKFGGIIVLATAKSQIFQVFYFRMYLGIVLFGAAHGLVFLPVMLSYIGSP 391
V G T G +++LA + ++F + L G HGLV LPV+LS +G P
Sbjct: 1062 VTDGAISTLLG-LLMLAGSHFDFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGPP 1117
>U59464-1|AAC50550.1| 1447|Homo sapiens PATCHED protein.
Length = 1447
Score = 61.3 bits (142), Expect = 4e-09
Identities = 39/115 (33%), Positives = 61/115 (53%)
Frame = -1
Query: 741 LGGLMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSFSVSXXXXXXXXXADALLRMGSS 562
L G+M GI L+AV +V L+ +VGI VEF H+ +F + AL M +
Sbjct: 1067 LFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNRRAVL-ALEHMFAP 1125
Query: 561 VLSGITLTKFGGIIVLATAKSQIFQVFYFRMYLGIVLFGAAHGLVFLPVMLSYIG 397
VL G T G +++LA ++ ++F + + + G +GLV LPV+LS+ G
Sbjct: 1126 VLDGAVSTLLG-VLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFG 1179
>AL161729-2|CAH73818.1| 1296|Homo sapiens patched homolog 1
(Drosophila) protein.
Length = 1296
Score = 61.3 bits (142), Expect = 4e-09
Identities = 39/115 (33%), Positives = 61/115 (53%)
Frame = -1
Query: 741 LGGLMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSFSVSXXXXXXXXXADALLRMGSS 562
L G+M GI L+AV +V L+ +VGI VEF H+ +F + AL M +
Sbjct: 916 LFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNRRAVL-ALEHMFAP 974
Query: 561 VLSGITLTKFGGIIVLATAKSQIFQVFYFRMYLGIVLFGAAHGLVFLPVMLSYIG 397
VL G T G +++LA ++ ++F + + + G +GLV LPV+LS+ G
Sbjct: 975 VLDGAVSTLLG-VLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFG 1028
>AL161729-1|CAH73817.1| 1447|Homo sapiens patched homolog 1
(Drosophila) protein.
Length = 1447
Score = 61.3 bits (142), Expect = 4e-09
Identities = 39/115 (33%), Positives = 61/115 (53%)
Frame = -1
Query: 741 LGGLMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSFSVSXXXXXXXXXADALLRMGSS 562
L G+M GI L+AV +V L+ +VGI VEF H+ +F + AL M +
Sbjct: 1067 LFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNRRAVL-ALEHMFAP 1125
Query: 561 VLSGITLTKFGGIIVLATAKSQIFQVFYFRMYLGIVLFGAAHGLVFLPVMLSYIG 397
VL G T G +++LA ++ ++F + + + G +GLV LPV+LS+ G
Sbjct: 1126 VLDGAVSTLLG-VLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFG 1179
>U43148-1|AAC50496.1| 1296|Homo sapiens PTC protein.
Length = 1296
Score = 58.4 bits (135), Expect = 3e-08
Identities = 38/115 (33%), Positives = 60/115 (52%)
Frame = -1
Query: 741 LGGLMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSFSVSXXXXXXXXXADALLRMGSS 562
L G+M GI L+AV +V L+ +VGI VEF H+ +F ++ AL M +
Sbjct: 916 LFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAF-LTAISDKNRRAVLALEHMFAP 974
Query: 561 VLSGITLTKFGGIIVLATAKSQIFQVFYFRMYLGIVLFGAAHGLVFLPVMLSYIG 397
VL G T G+++LA + ++F + + + G +GLV LPV+ S+ G
Sbjct: 975 VLDGAVSTLL-GVLMLAGSDFDFIVRYFFAVLAILTILGVLNGLVLLPVLWSFFG 1028
>AL161622-2|CAI20456.1| 510|Homo sapiens protein ( vel protein
similar to seven ).).
Length = 510
Score = 46.0 bits (104), Expect = 2e-04
Identities = 28/130 (21%), Positives = 58/130 (44%)
Frame = -1
Query: 735 GLMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSFSVSXXXXXXXXXADALLRMGSSVL 556
GLM W + ++ +S++ L+ + +++ C+ L+ +F ++ +L G+++L
Sbjct: 365 GLMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHTRTQCIKSSLQDHGTAIL 424
Query: 555 SGITLTKFGGIIVLATAKSQIFQVFYFRMYLGIVLFGAAHGLVFLPVMLSYIGSPVNKQK 376
+T G + +L + F +F + G H V LPV L++ P K
Sbjct: 425 QNVTSFLIGLVPLLFVPSNLTFTLFKCLLLTGGCTL--LHCFVILPVFLTFF-PPSKKHH 481
Query: 375 LANQRRRGNE 346
+R + E
Sbjct: 482 KKKKRAKRKE 491
>AY395772-1|AAR21240.1| 345|Homo sapiens patched protein.
Length = 345
Score = 39.1 bits (87), Expect = 0.018
Identities = 21/63 (33%), Positives = 35/63 (55%)
Frame = -1
Query: 585 ALLRMGSSVLSGITLTKFGGIIVLATAKSQIFQVFYFRMYLGIVLFGAAHGLVFLPVMLS 406
AL M + VL G T G +++LA ++ ++F + + + G +GLV LPV+LS
Sbjct: 16 ALEHMFAPVLDGAVSTLLG-VLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLS 74
Query: 405 YIG 397
+ G
Sbjct: 75 FFG 77
>AL590989-2|CAH70606.1| 1438|Homo sapiens patched domain containing 2
protein.
Length = 1438
Score = 39.1 bits (87), Expect = 0.018
Identities = 15/35 (42%), Positives = 23/35 (65%)
Frame = -1
Query: 732 LMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSF 628
+MYW G + AV ++L + VG SV++C HLV +
Sbjct: 1271 IMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGY 1305
>AL031735-1|CAI22474.1| 1438|Homo sapiens patched domain containing 2
protein.
Length = 1438
Score = 39.1 bits (87), Expect = 0.018
Identities = 15/35 (42%), Positives = 23/35 (65%)
Frame = -1
Query: 732 LMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSF 628
+MYW G + AV ++L + VG SV++C HLV +
Sbjct: 1271 IMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGY 1305
>AB037758-1|BAA92575.1| 1438|Homo sapiens KIAA1337 protein protein.
Length = 1438
Score = 39.1 bits (87), Expect = 0.018
Identities = 15/35 (42%), Positives = 23/35 (65%)
Frame = -1
Query: 732 LMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSF 628
+MYW G + AV ++L + VG SV++C HLV +
Sbjct: 1271 IMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGY 1305
>AB209495-1|BAD92732.1| 586|Homo sapiens patched variant protein.
Length = 586
Score = 38.3 bits (85), Expect = 0.031
Identities = 28/77 (36%), Positives = 41/77 (53%)
Frame = -1
Query: 741 LGGLMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSFSVSXXXXXXXXXADALLRMGSS 562
L G+M GI L+AV +V L+ +VGI VEF H+ +F ++ AL M +
Sbjct: 503 LFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAF-LTAIGDKNRRAVLALEHMFAP 561
Query: 561 VLSGITLTKFGGIIVLA 511
VL G T G+++LA
Sbjct: 562 VLDGAVSTLL-GVLMLA 577
>AL592166-13|CAI13008.1| 87|Homo sapiens patched homolog 2
(Drosophila) protein.
Length = 87
Score = 34.3 bits (75), Expect = 0.51
Identities = 14/31 (45%), Positives = 19/31 (61%)
Frame = -1
Query: 483 FYFRMYLGIVLFGAAHGLVFLPVMLSYIGSP 391
++F + L G HGLV LPV+LS +G P
Sbjct: 7 YFFAALTVLTLLGLLHGLVLLPVLLSILGPP 37
>CR457373-1|CAG33654.1| 204|Homo sapiens NIF3L1BP1 protein.
Length = 204
Score = 32.7 bits (71), Expect = 1.5
Identities = 14/32 (43%), Positives = 23/32 (71%)
Frame = +1
Query: 415 NRQEYESVGRTEQHNPEVHPEVEHLEDLALGR 510
NRQEY+++ + QH+P+ H ++ LE ALG+
Sbjct: 115 NRQEYDALAKVIQHHPDRHETLKELE--ALGK 144
>BC065012-1|AAH65012.1| 204|Homo sapiens THO complex 7 homolog
(Drosophila) protein.
Length = 204
Score = 32.7 bits (71), Expect = 1.5
Identities = 14/32 (43%), Positives = 23/32 (71%)
Frame = +1
Query: 415 NRQEYESVGRTEQHNPEVHPEVEHLEDLALGR 510
NRQEY+++ + QH+P+ H ++ LE ALG+
Sbjct: 115 NRQEYDALAKVIQHHPDRHETLKELE--ALGK 144
>BC020599-1|AAH20599.2| 197|Homo sapiens THOC7 protein protein.
Length = 197
Score = 32.7 bits (71), Expect = 1.5
Identities = 14/32 (43%), Positives = 23/32 (71%)
Frame = +1
Query: 415 NRQEYESVGRTEQHNPEVHPEVEHLEDLALGR 510
NRQEY+++ + QH+P+ H ++ LE ALG+
Sbjct: 108 NRQEYDALAKVIQHHPDRHETLKELE--ALGK 137
>AK027098-1|BAB15656.1| 204|Homo sapiens protein ( Homo sapiens
cDNA: FLJ23445 fis, clone HSI01721. ).
Length = 204
Score = 32.7 bits (71), Expect = 1.5
Identities = 14/32 (43%), Positives = 23/32 (71%)
Frame = +1
Query: 415 NRQEYESVGRTEQHNPEVHPEVEHLEDLALGR 510
NRQEY+++ + QH+P+ H ++ LE ALG+
Sbjct: 115 NRQEYDALAKVIQHHPDRHETLKELE--ALGK 144
>BC011542-1|AAH11542.2| 1011|Homo sapiens DISP1 protein protein.
Length = 1011
Score = 31.9 bits (69), Expect = 2.7
Identities = 21/91 (23%), Positives = 41/91 (45%)
Frame = -1
Query: 735 GLMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSFSVSXXXXXXXXXADALLRMGSSVL 556
G + G LN + V + +AVG+SV+F H ++ ++ +L R+GS++
Sbjct: 512 GSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMA 571
Query: 555 SGITLTKFGGIIVLATAKSQIFQVFYFRMYL 463
T G +++ + Q+ F M +
Sbjct: 572 MAALTTFVAGAMMMPSTVLAYTQLGTFMMLI 602
>AK026114-1|BAB15365.1| 917|Homo sapiens protein ( Homo sapiens
cDNA: FLJ22461 fis, clone HRC10107. ).
Length = 917
Score = 31.9 bits (69), Expect = 2.7
Identities = 21/91 (23%), Positives = 41/91 (45%)
Frame = -1
Query: 735 GLMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSFSVSXXXXXXXXXADALLRMGSSVL 556
G + G LN + V + +AVG+SV+F H ++ ++ +L R+GS++
Sbjct: 418 GSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMA 477
Query: 555 SGITLTKFGGIIVLATAKSQIFQVFYFRMYL 463
T G +++ + Q+ F M +
Sbjct: 478 MAALTTFVAGAMMMPSTVLAYTQLGTFMMLI 508
>AK023679-1|BAB14637.1| 637|Homo sapiens protein ( Homo sapiens
cDNA FLJ13617 fis, clone PLACE1010917. ).
Length = 637
Score = 31.9 bits (69), Expect = 2.7
Identities = 21/91 (23%), Positives = 41/91 (45%)
Frame = -1
Query: 735 GLMYWWGISLNAVSLVNLVMAVGISVEFCSHLVHSFSVSXXXXXXXXXADALLRMGSSVL 556
G + G LN + V + +AVG+SV+F H ++ ++ +L R+GS++
Sbjct: 241 GSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMA 300
Query: 555 SGITLTKFGGIIVLATAKSQIFQVFYFRMYL 463
T G +++ + Q+ F M +
Sbjct: 301 MAALTTFVAGAMMMPSTVLAYTQLGTFMMLI 331
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 89,673,518
Number of Sequences: 237096
Number of extensions: 1629735
Number of successful extensions: 3444
Number of sequences better than 10.0: 36
Number of HSP's better than 10.0 without gapping: 3349
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3428
length of database: 76,859,062
effective HSP length: 89
effective length of database: 55,757,518
effective search space used: 9590293096
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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