Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fcaL-P09_F_E12
(839 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P48735 Cluster: Isocitrate dehydrogenase [NADP], mitoch... 404 e-111
UniRef50_Q8LPJ5 Cluster: Isocitrate dehydrogenase-like protein; ... 388 e-107
UniRef50_Q9SRZ6 Cluster: F12P19.10 protein; n=26; cellular organ... 371 e-101
UniRef50_Q0CXI1 Cluster: Isocitrate dehydrogenase, mitochondrial... 334 2e-90
UniRef50_A2WMU2 Cluster: Putative uncharacterized protein; n=5; ... 330 3e-89
UniRef50_A5N5L9 Cluster: Idh; n=2; Bacteria|Rep: Idh - Clostridi... 308 2e-82
UniRef50_A5ZVX5 Cluster: Putative uncharacterized protein; n=1; ... 305 6e-82
UniRef50_UPI0000F1EC8D Cluster: PREDICTED: similar to Isocitrate... 249 6e-65
UniRef50_A2XVE4 Cluster: Putative uncharacterized protein; n=2; ... 164 2e-51
UniRef50_A3JDN6 Cluster: Isocitrate dehydrogenase; n=5; Gammapro... 127 4e-28
UniRef50_Q00WM7 Cluster: COG0538: Isocitrate dehydrogenases; n=3... 125 2e-27
UniRef50_Q2K7T8 Cluster: NADP-dependent isocitrate dehydrogenase... 113 7e-24
UniRef50_Q4VCC2 Cluster: Isocitrate dehydrogenase; n=4; Eukaryot... 112 1e-23
UniRef50_A3K670 Cluster: NADP-dependent isocitrate dehydrogenase... 98 3e-19
UniRef50_Q5DBI8 Cluster: SJCHGC09598 protein; n=1; Schistosoma j... 85 2e-15
UniRef50_A4VDP7 Cluster: Putative uncharacterized protein; n=1; ... 71 4e-11
UniRef50_Q67N12 Cluster: 3-isopropylmalate dehydrogenase; n=5; B... 52 2e-05
UniRef50_Q40658 Cluster: Isocitrate dehydrogenase; n=1; Oryza sa... 44 0.005
UniRef50_A0C1D3 Cluster: Chromosome undetermined scaffold_141, w... 36 1.7
UniRef50_Q5E609 Cluster: Putative uncharacterized protein; n=1; ... 35 2.2
UniRef50_A4WT53 Cluster: Sensor protein; n=3; Rhodobacter sphaer... 35 2.9
UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5; T... 35 2.9
UniRef50_Q0SU98 Cluster: DNA/RNA helicase, SNF2; n=2; Clostridiu... 34 5.1
UniRef50_UPI0000498AD5 Cluster: hypothetical membrane-spanning p... 33 8.9
UniRef50_Q142V0 Cluster: Putative uncharacterized protein; n=1; ... 33 8.9
>UniRef50_P48735 Cluster: Isocitrate dehydrogenase [NADP],
mitochondrial precursor (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH); n=493;
cellular organisms|Rep: Isocitrate dehydrogenase [NADP],
mitochondrial precursor (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) - Homo
sapiens (Human)
Length = 452
Score = 404 bits (994), Expect = e-111
Identities = 186/273 (68%), Positives = 217/273 (79%), Gaps = 2/273 (0%)
Frame = +3
Query: 27 RHRYNMSKIK-AGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQ 203
R Y +IK A PVV++ GDEMTRIIW IKEKLILP +DI+L +DLG+ NRD+TDDQ
Sbjct: 36 RRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQ 95
Query: 204 VTIDCAEAIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICK 383
VTID A A +KY+V +KCATITPDE RVEEFKLKKMWKSPNGTIRNILGGTVFRE IICK
Sbjct: 96 VTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICK 155
Query: 384 NIPRLVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEAIKH-VVHEYKGA 560
NIPRLV GW KPI IGRHAH DQYKATDFV AGT +++F P+ G +K V+ +
Sbjct: 156 NIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAG 215
Query: 561 GVALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDREYK 740
GV + M+NTD SI FAHS F++A+ +K+PLY+STKNTILK YDGRFKDIFQ+I+D+ YK
Sbjct: 216 GVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYK 275
Query: 741 KQFEDAGIWYEHRLIDDMVAYAMKSXGGFVWAC 839
F+ IWYEHRLIDDMVA +KS GGFVWAC
Sbjct: 276 TDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWAC 308
>UniRef50_Q8LPJ5 Cluster: Isocitrate dehydrogenase-like protein;
n=6; core eudicotyledons|Rep: Isocitrate
dehydrogenase-like protein - Arabidopsis thaliana
(Mouse-ear cress)
Length = 485
Score = 388 bits (956), Expect = e-107
Identities = 175/260 (67%), Positives = 215/260 (82%), Gaps = 1/260 (0%)
Frame = +3
Query: 63 PVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYN 242
P+V++ GDEMTR+IW +IKEKLILP+LD+++ +DLG+ NRD TDD+VT++ AEA KYN
Sbjct: 81 PIVEMDGDEMTRVIWSMIKEKLILPYLDLDIKYFDLGILNRDATDDKVTVESAEAALKYN 140
Query: 243 VGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPI 422
V IKCATITPDE RV+EF LK MW+SPNGTIRNIL GTVFRE I+C NIPRLV GW+KPI
Sbjct: 141 VAIKCATITPDEGRVKEFGLKSMWRSPNGTIRNILDGTVFREPIMCSNIPRLVPGWEKPI 200
Query: 423 IIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEA-IKHVVHEYKGAGVALAMFNTDASI 599
IGRHA DQY+ATD V+ G G L+++F PE G A ++ V+++KG GVALAM+N D SI
Sbjct: 201 CIGRHAFGDQYRATDTVIKGPGKLKMVFVPEDGNAPVELDVYDFKGPGVALAMYNVDESI 260
Query: 600 IDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDREYKKQFEDAGIWYEHR 779
FA SS AL +K+PLYLSTKNTILKKYDGRFKDIFQ++Y+ +K++FE+ IWYEHR
Sbjct: 261 RAFAESSMAMALTKKWPLYLSTKNTILKKYDGRFKDIFQEVYEANWKQKFEEHSIWYEHR 320
Query: 780 LIDDMVAYAMKSXGGFVWAC 839
LIDDMVAYA+KS GG+VWAC
Sbjct: 321 LIDDMVAYAVKSEGGYVWAC 340
>UniRef50_Q9SRZ6 Cluster: F12P19.10 protein; n=26; cellular
organisms|Rep: F12P19.10 protein - Arabidopsis thaliana
(Mouse-ear cress)
Length = 410
Score = 371 bits (912), Expect = e-101
Identities = 170/265 (64%), Positives = 210/265 (79%), Gaps = 1/265 (0%)
Frame = +3
Query: 48 KIK-AGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAE 224
KIK A P+V++ GDEMTR+IW IK+KLI PF+++++ +DLG+ +RD TDD+VTI+ AE
Sbjct: 5 KIKVANPIVEMDGDEMTRVIWKSIKDKLITPFVELDIKYFDLGLPHRDATDDKVTIESAE 64
Query: 225 AIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVT 404
A KKYNV IKCATITPDE RV EF LK+MW+SPNGTIRNIL GTVFRE IICKN+P+LV
Sbjct: 65 ATKKYNVAIKCATITPDEGRVTEFGLKQMWRSPNGTIRNILNGTVFREPIICKNVPKLVP 124
Query: 405 GWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEAIKHVVHEYKGAGVALAMFN 584
GW KPI IGRHA DQY+ATD V+ G G L + F+ + G+ V GVA+AM+N
Sbjct: 125 GWTKPICIGRHAFGDQYRATDAVIKGPGKLTMTFEGKDGKTETEVFTFTGEGGVAMAMYN 184
Query: 585 TDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDREYKKQFEDAGI 764
TD SI FA +S A ++K+PLYLSTKNTILKKYDGRFKDIFQ++Y+ +K +++ AGI
Sbjct: 185 TDESIRAFADASMNTAYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEASWKSKYDAAGI 244
Query: 765 WYEHRLIDDMVAYAMKSXGGFVWAC 839
WYEHRLIDDMVAYA+KS GG+VWAC
Sbjct: 245 WYEHRLIDDMVAYALKSEGGYVWAC 269
>UniRef50_Q0CXI1 Cluster: Isocitrate dehydrogenase, mitochondrial;
n=2; Eurotiomycetidae|Rep: Isocitrate dehydrogenase,
mitochondrial - Aspergillus terreus (strain NIH 2624)
Length = 466
Score = 334 bits (821), Expect = 2e-90
Identities = 154/223 (69%), Positives = 184/223 (82%), Gaps = 1/223 (0%)
Frame = +3
Query: 171 GMENRDKTDDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILG 350
G+E RD+TDD+VT++ AEAIKKY VG+KCATITPDE RVEEFKLKKMW SPNGTIRNILG
Sbjct: 101 GIEYRDQTDDKVTVEAAEAIKKYGVGVKCATITPDEARVEEFKLKKMWLSPNGTIRNILG 160
Query: 351 GTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEAI 530
GTVFRE I+ IPRLV GW KPIIIGRHA DQY+ATD V+PG G LE+++ P +G+
Sbjct: 161 GTVFREPIVIPAIPRLVPGWTKPIIIGRHAFGDQYRATDRVIPGPGKLELVYTPANGQPE 220
Query: 531 KHVVHEYK-GAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKD 707
V++++ G GVA++M+NTD SI FAHSSFK AL + PLY+STKNTILK+YDGRFKD
Sbjct: 221 SVQVYDFQSGGGVAMSMYNTDDSIRGFAHSSFKMALLKGLPLYMSTKNTILKRYDGRFKD 280
Query: 708 IFQDIYDREYKKQFEDAGIWYEHRLIDDMVAYAMKSXGGFVWA 836
IFQ+IY+ EYKK+F+ GIWYEHRLIDDMVA +KS GGF+ A
Sbjct: 281 IFQEIYEAEYKKEFDAKGIWYEHRLIDDMVAQMIKSEGGFIMA 323
>UniRef50_A2WMU2 Cluster: Putative uncharacterized protein; n=5;
Eukaryota|Rep: Putative uncharacterized protein - Oryza
sativa subsp. indica (Rice)
Length = 475
Score = 330 bits (811), Expect = 3e-89
Identities = 171/290 (58%), Positives = 202/290 (69%), Gaps = 37/290 (12%)
Frame = +3
Query: 81 GDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCA 260
GDEMTR+IW IK+KLI PFLD+++ YDLG+ NRD T D+VTI+ AEA KYNV IKCA
Sbjct: 42 GDEMTRVIWKWIKDKLIFPFLDLDIKYYDLGLPNRDATGDKVTIESAEATLKYNVAIKCA 101
Query: 261 TITP------------------DEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKN 386
TITP DE RV+EF L MWKSPNGTIRNIL GTVFRE IICKN
Sbjct: 102 TITPVLDTQFKFDFGRTIHEPTDEGRVKEFNLSAMWKSPNGTIRNILNGTVFREPIICKN 161
Query: 387 IPRLVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEAIKHVVHEYKGA-G 563
IPRLV GW KPI IGRHA DQY+ATD V+ G G L+++F E I+ V + GA G
Sbjct: 162 IPRLVPGWIKPICIGRHAFGDQYRATDTVIKGPGKLKLVFDGRE-EQIELDVFNFTGAGG 220
Query: 564 VALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDREYKK 743
VAL+M+NTD SI FA +S A +++PLYLSTKNTILKKYDGRFKDIFQ+ Y+ +++
Sbjct: 221 VALSMYNTDESIWAFAEASMNMAYQKRWPLYLSTKNTILKKYDGRFKDIFQENYETKWRA 280
Query: 744 QFEDAGIW------------------YEHRLIDDMVAYAMKSXGGFVWAC 839
+F+DAGIW YEHRLIDDMVAYA+KS GG+VWAC
Sbjct: 281 KFDDAGIWNMEPYFPPLCPNHFCCGRYEHRLIDDMVAYALKSEGGYVWAC 330
>UniRef50_A5N5L9 Cluster: Idh; n=2; Bacteria|Rep: Idh - Clostridium
kluyveri DSM 555
Length = 401
Score = 308 bits (755), Expect = 2e-82
Identities = 142/265 (53%), Positives = 187/265 (70%), Gaps = 1/265 (0%)
Frame = +3
Query: 48 KIKAG-PVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAE 224
KIK P+V++ GDEMTRIIW +IKE L+ P++D++ YDLG+ R++T+D++TI+ A
Sbjct: 4 KIKMNVPLVEMDGDEMTRIIWKMIKELLLEPYIDLKTEYYDLGLVKRNETNDEITIEAAN 63
Query: 225 AIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVT 404
AIKKY VG+KCATITP+ KRV+E+ LK MWKSPNGTIR IL GTVFR II +I L+
Sbjct: 64 AIKKYGVGVKCATITPNAKRVKEYNLKSMWKSPNGTIRAILDGTVFRTPIIVNSIRPLMR 123
Query: 405 GWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEAIKHVVHEYKGAGVALAMFN 584
W+KPI + RHA+ D Y+ ++ V G +E++F E GE + +H + G GV + M N
Sbjct: 124 TWEKPITVARHAYGDVYRDVEYKVEEPGKMELVFTSEKGEETRQTLHVFNGPGVVMGMHN 183
Query: 585 TDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDREYKKQFEDAGI 764
D SI FA S F +ALD L+ ++K+TI K YD RFKDIFQ+IYD EY +F DAGI
Sbjct: 184 LDKSIESFARSCFNYALDMNQNLWFASKDTISKTYDHRFKDIFQEIYDTEYDAKFNDAGI 243
Query: 765 WYEHRLIDDMVAYAMKSXGGFVWAC 839
Y + LIDD VA +KS GGF+WAC
Sbjct: 244 EYFYTLIDDAVARVVKSEGGFIWAC 268
>UniRef50_A5ZVX5 Cluster: Putative uncharacterized protein; n=1;
Ruminococcus obeum ATCC 29174|Rep: Putative
uncharacterized protein - Ruminococcus obeum ATCC 29174
Length = 417
Score = 305 bits (750), Expect = 6e-82
Identities = 139/267 (52%), Positives = 189/267 (70%), Gaps = 1/267 (0%)
Frame = +3
Query: 42 MSKIK-AGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDC 218
M KI+ P+V++ GDEMTRI+W +IK++L+LPF+D+ YDLG+ R++TDDQVTID
Sbjct: 16 MEKIQMTTPLVEMDGDEMTRILWKMIKDELLLPFIDLNTEYYDLGLNYRNETDDQVTIDA 75
Query: 219 AEAIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRL 398
AEA KKY V +KCATITP+ R++E+ LKKM+KSPNGTIR IL GTVFR I+ K I
Sbjct: 76 AEATKKYGVAVKCATITPNHARMDEYDLKKMYKSPNGTIRAILDGTVFRAPIVVKGIEPC 135
Query: 399 VTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEAIKHVVHEYKGAGVALAM 578
V W KPI + RHA+ D YK T+ + G +E+++ E GE + +V E+K GVA+ M
Sbjct: 136 VRNWKKPITLARHAYGDIYKNTEMYIDKPGKVELVYTSEDGEEKRSLVQEFKAPGVAMGM 195
Query: 579 FNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDREYKKQFEDA 758
N ASI FA S F +ALD K ++ K+TI K YD +FK++FQ ++D E+K +FE+A
Sbjct: 196 HNMTASIESFARSCFNYALDTKQDVWFGAKDTISKTYDAKFKEVFQTVFDTEFKDRFEEA 255
Query: 759 GIWYEHRLIDDMVAYAMKSXGGFVWAC 839
G+ Y + LIDD+VA MK+ GGF+WAC
Sbjct: 256 GLTYFYSLIDDIVARVMKAEGGFIWAC 282
>UniRef50_UPI0000F1EC8D Cluster: PREDICTED: similar to Isocitrate
dehydrogenase 1 (NADP+), soluble; n=2; Danio rerio|Rep:
PREDICTED: similar to Isocitrate dehydrogenase 1
(NADP+), soluble - Danio rerio
Length = 206
Score = 249 bits (610), Expect = 6e-65
Identities = 112/140 (80%), Positives = 129/140 (92%), Gaps = 1/140 (0%)
Frame = +3
Query: 36 YNMS-KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTI 212
+ MS KIKAG VV++ GDEMTR+IW+LIKEKLI P+L+++LH YDLGMENRD TDD+VT+
Sbjct: 6 FKMSQKIKAGSVVEMQGDEMTRVIWELIKEKLIFPYLELDLHSYDLGMENRDATDDKVTV 65
Query: 213 DCAEAIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIP 392
+ AEA+++YNVGIKCATITPDEKRVEEFKLK+MW+SPNGTIRNILGGTVFREAIICKNIP
Sbjct: 66 EAAEAVRRYNVGIKCATITPDEKRVEEFKLKQMWRSPNGTIRNILGGTVFREAIICKNIP 125
Query: 393 RLVTGWDKPIIIGRHAHADQ 452
RLV GW KPIIIGRHAH DQ
Sbjct: 126 RLVPGWIKPIIIGRHAHGDQ 145
>UniRef50_A2XVE4 Cluster: Putative uncharacterized protein; n=2;
Oryza sativa|Rep: Putative uncharacterized protein -
Oryza sativa subsp. indica (Rice)
Length = 371
Score = 164 bits (399), Expect(2) = 2e-51
Identities = 72/114 (63%), Positives = 92/114 (80%)
Frame = +3
Query: 498 IIFKPESGEAIKHVVHEYKGAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTI 677
I+ P+ E ++ V+ +KG GVAL+M+N D SI FA SS AL +K+PLYLSTKNTI
Sbjct: 30 ILSVPDGAEPVELNVYNFKGPGVALSMYNVDESIRAFAESSMAMALSKKWPLYLSTKNTI 89
Query: 678 LKKYDGRFKDIFQDIYDREYKKQFEDAGIWYEHRLIDDMVAYAMKSXGGFVWAC 839
LKKYDGRFKDIFQ++Y+ ++K++FE+ IWYEHRLIDDMVAYA+KS GG+VWAC
Sbjct: 90 LKKYDGRFKDIFQEVYEEKWKEKFEENSIWYEHRLIDDMVAYAVKSEGGYVWAC 143
Score = 83.4 bits (197), Expect = 6e-15
Identities = 37/57 (64%), Positives = 47/57 (82%)
Frame = +3
Query: 594 SIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDREYKKQFEDAGI 764
SI FA SS AL +K+PLYLSTKNTILKKYDGRFKDIFQ++Y+ ++K++FE+ I
Sbjct: 158 SIRAFAESSMAMALSKKWPLYLSTKNTILKKYDGRFKDIFQEVYEEKWKEKFEENSI 214
Score = 62.1 bits (144), Expect(2) = 2e-51
Identities = 24/32 (75%), Positives = 30/32 (93%)
Frame = +3
Query: 309 MWKSPNGTIRNILGGTVFREAIICKNIPRLVT 404
MW+SPNGTIRNIL GTVFRE I+CKN+PR+++
Sbjct: 1 MWRSPNGTIRNILNGTVFREPILCKNVPRILS 32
>UniRef50_A3JDN6 Cluster: Isocitrate dehydrogenase; n=5;
Gammaproteobacteria|Rep: Isocitrate dehydrogenase -
Marinobacter sp. ELB17
Length = 582
Score = 127 bits (306), Expect = 4e-28
Identities = 84/266 (31%), Positives = 138/266 (51%), Gaps = 13/266 (4%)
Frame = +3
Query: 42 MSKIKA-GPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDC 218
++KI+ P+V + GDEM ++ ++ I +K + L IEL DL E+R T+ QV +
Sbjct: 2 VNKIQVESPLVILHGDEMAQVAFEEILKKFVTTRLAIELIEIDLSAEHRFLTNGQVIFEA 61
Query: 219 AEAIKKYNVGIKCATITPDEKRVE-------EFKLKKM----WKSPNGTIRNILGGTVFR 365
EA+KKY VG+K A +T + ++++ E ++ KSPNG IR +GG + R
Sbjct: 62 IEALKKYGVGVKNAGMTVNREQLDAMLEKHPELSQSRLDPLATKSPNGAIRKGIGGNITR 121
Query: 366 EAIICKNIPRLVTGW-DKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEAIKHVV 542
E I +N+ W D+ I + + + + + G ++++F +SG ++
Sbjct: 122 EDIQFQNLRVRKPDWIDRDIDVDTMDNGGIKDSYNELSSSTGVVKLLFVGKSGNPVELHR 181
Query: 543 HEYKGAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDI 722
+ K L N A + +AH F+ A+D K YL K+T++ YDG + + I
Sbjct: 182 RDVKKGDPWLLATNDIADVKAWAHRFFQRAIDEKRDAYLGLKDTVIAGYDGVMRAAIEAI 241
Query: 723 YDREYKKQFEDAGIWYEHRLIDDMVA 800
Y +EYKKQFE GI Y + L+D A
Sbjct: 242 YKQEYKKQFEAVGINYYYELVDAQAA 267
>UniRef50_Q00WM7 Cluster: COG0538: Isocitrate dehydrogenases; n=3;
Ostreococcus|Rep: COG0538: Isocitrate dehydrogenases -
Ostreococcus tauri
Length = 429
Score = 125 bits (301), Expect = 2e-27
Identities = 87/250 (34%), Positives = 128/250 (51%), Gaps = 7/250 (2%)
Frame = +3
Query: 45 SKIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIE-LHVYDLGMENRDKTDDQVTIDCA 221
SKI A P+V + G+EMT + DLI+ + I P +D+ +DL +NRD T+D+V D
Sbjct: 24 SKITAAPMVYVRGEEMTAYVMDLIRSRWIEPRVDVGGWETFDLRAKNRDDTEDRVLRDVI 83
Query: 222 EAIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGG-TVFREAIICKNIPRL 398
EA K+ K T+TP +V+ L+K W SPNG +R G T+ R+ I +I +
Sbjct: 84 EAGKRIKAIFKEPTVTPTADQVKRLGLRKSWGSPNGAMRRGWNGITISRDTI---HIDGV 140
Query: 399 VTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESG-EAIKHVV---HEYKGAGV 566
G+ KP++ RHA +Y A + G G L F P G +A K VV E
Sbjct: 141 ELGYKKPVLFERHAVGGEYSA-GYKNVGKGKLTTTFTPSEGPDAGKTVVVDEREIVDEEA 199
Query: 567 ALAMF-NTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDREYKK 743
A+ + N ++ D A F L+ K Y+ TK T+ K+ F I + ++D E+K
Sbjct: 200 AVVTYHNPYDNVHDLARFFFGRCLEAKVTPYVVTKKTVF-KWQEPFWQIMRTVFDEEFKA 258
Query: 744 QFEDAGIWYE 773
QF AG+ E
Sbjct: 259 QFVAAGVMKE 268
>UniRef50_Q2K7T8 Cluster: NADP-dependent isocitrate dehydrogenase
protein; n=1; Rhizobium etli CFN 42|Rep: NADP-dependent
isocitrate dehydrogenase protein - Rhizobium etli
(strain CFN 42 / ATCC 51251)
Length = 437
Score = 113 bits (271), Expect = 7e-24
Identities = 70/258 (27%), Positives = 131/258 (50%)
Frame = -1
Query: 839 AGPDKSTL*FXXXXXXXIN*PVFIPDTSILKLFLVLPVINILKDVFETTIVFLENCILSA 660
AGPD ++ ++ VF+ D L+L L +++ L+DV E ++ LE+ +L
Sbjct: 156 AGPDVASGPLQGRGDHVVDQTVFVGDPGFLELILEFGLVDFLEDVLEAAVIGLEDGVLGR 215
Query: 659 *VQRVFSVQSKLE*RMSKVNNRCISVKHSQCYTCTLVLMNYMFYCLTRFRFEDYFKSTST 480
V R F+ Q+ + +R + V H + + + F E +
Sbjct: 216 QVDRPFAHQAVHHRGAGEFADRFVEVVHGHGNAGARRVEDLLLDDGAVFTDELDRQLALA 275
Query: 479 WDNKVSCFVLISMSMTSNDDGFVPPCYKSRYILANNSLPENSTTKNITDGPIRAFPHFLQ 300
+ +V C VL++ S+T++DD P ++R + A++ L E+ +N++D +RA PHFL+
Sbjct: 276 GELEVGCAVLVAESVTADDDRLRPAGNEARNVAADDRLAEDDAAENVSDRAVRALPHFLE 335
Query: 299 FKFFNSLLIRSYGRTFDAHIVFLYGLSTINCNLIISLITIFHTQVVDM*FNVQERKNQLF 120
+F ++ IR D VFL G+ ++ +L++ + IF +VV + V+ R +QL
Sbjct: 336 IEFLDAGFIRRDRCALDTDAVFLDGVGGVDRHLVVGGVAIFDREVVIVDIEVEIRMDQLI 395
Query: 119 FDKIPDYSGHFITKDVNN 66
D++PD + HFI ++ +
Sbjct: 396 LDELPDDACHFIAVEIGD 413
>UniRef50_Q4VCC2 Cluster: Isocitrate dehydrogenase; n=4;
Eukaryota|Rep: Isocitrate dehydrogenase - Saltugilia
latimeri
Length = 158
Score = 112 bits (269), Expect = 1e-23
Identities = 48/70 (68%), Positives = 59/70 (84%)
Frame = +3
Query: 585 TDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDREYKKQFEDAGI 764
TD SI FA +S A ++K+PLYLSTKNTILKKYDGRFKDIFQ++Y++ +K ++E AGI
Sbjct: 1 TDESIYSFAEASMTTAYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEKSWKSKYEAAGI 60
Query: 765 WYEHRLIDDM 794
WYEHRLIDDM
Sbjct: 61 WYEHRLIDDM 70
>UniRef50_A3K670 Cluster: NADP-dependent isocitrate dehydrogenase
protein; n=2; Rhodobacteraceae|Rep: NADP-dependent
isocitrate dehydrogenase protein - Sagittula stellata
E-37
Length = 459
Score = 97.9 bits (233), Expect = 3e-19
Identities = 62/259 (23%), Positives = 128/259 (49%)
Frame = -1
Query: 839 AGPDKSTL*FXXXXXXXIN*PVFIPDTSILKLFLVLPVINILKDVFETTIVFLENCILSA 660
AGPD+ + ++ PV +PD L+L L ++++L+ V E +V LEN +L
Sbjct: 187 AGPDELAVPLERAGHHVVDQPVLVPDALRLELLGKLRLVDLLEQVLEPPVVGLENGVLGR 246
Query: 659 *VQRVFSVQSKLE*RMSKVNNRCISVKHSQCYTCTLVLMNYMFYCLTRFRFEDYFKSTST 480
V R Q+ ++ KV +R + V H+ +++ L F + +
Sbjct: 247 QVHRPAQRQTVVQRGAGKVADRLVLVVHAHVDPGIGRVVDLALDHLAVGAFPFHRQLARR 306
Query: 479 WDNKVSCFVLISMSMTSNDDGFVPPCYKSRYILANNSLPENSTTKNITDGPIRAFPHFLQ 300
+ ++ VL++ + ++ DG P +++R++ A++ L E+ +++ D + PH L+
Sbjct: 307 GEVEIRGLVLVAEGVPAHHDGRGPARHEARHVAADDRLAEDDAAQDVADRAVGRLPHLLE 366
Query: 299 FKFFNSLLIRSYGRTFDAHIVFLYGLSTINCNLIISLITIFHTQVVDM*FNVQERKNQLF 120
+F ++LL+R R FD L ++ +L+ + + ++V V+ R++QLF
Sbjct: 367 TEFLDTLLVRGDRRAFDRDANLLRLFGGVDGDLVPGPVPLLDPEIVVKQVQVEVRQDQLF 426
Query: 119 FDKIPDYSGHFITKDVNNR 63
D+ P +GH + +++R
Sbjct: 427 LDESPHDAGHLVAVHLHDR 445
>UniRef50_Q5DBI8 Cluster: SJCHGC09598 protein; n=1; Schistosoma
japonicum|Rep: SJCHGC09598 protein - Schistosoma
japonicum (Blood fluke)
Length = 129
Score = 85.4 bits (202), Expect = 2e-15
Identities = 51/91 (56%), Positives = 55/91 (60%)
Frame = -2
Query: 373 IASLKTVPPRILRMVPLGLFHIXXXXXXXXXXXSGVMVAHLMPTLYFFMASAQSIVT*SS 194
+ S KTVPPRILR+VP G HI SGVMVAHL+PTLYF +ASA SIVT S
Sbjct: 1 MGSRKTVPPRILRIVPFGDSHIFFKLNSLTRCSSGVMVAHLIPTLYFLIASAPSIVTWSL 60
Query: 193 VLSRFSIPKS*TCNSMSKKGRISFSLIRSQI 101
V SR PKS S S G IS IRS I
Sbjct: 61 VRSRLGRPKSKYLQSTSINGNISCCFIRSII 91
>UniRef50_A4VDP7 Cluster: Putative uncharacterized protein; n=1;
Tetrahymena thermophila SB210|Rep: Putative
uncharacterized protein - Tetrahymena thermophila SB210
Length = 141
Score = 70.9 bits (166), Expect = 4e-11
Identities = 49/103 (47%), Positives = 59/103 (57%)
Frame = -2
Query: 343 ILRMVPLGLFHIXXXXXXXXXXXSGVMVAHLMPTLYFFMASAQSIVT*SSVLSRFSIPKS 164
+LR+VPLG HI S V+VAHL+PTL +A A S VT S V SRFSI +S
Sbjct: 1 MLRIVPLGEGHIFLSLNSLTRASSAVIVAHLIPTLCSRIAQAASKVTQSLVASRFSIERS 60
Query: 163 *TCNSMSKKGRISFSLIRSQIILVISSPRMSTTGPAFILDILY 35
S G +S SLI Q+I VISSP ST G F+ IL+
Sbjct: 61 QYLISAEINGNMSLSLIIFQMIRVISSPSKSTIG--FLTLILF 101
>UniRef50_Q67N12 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Symbiobacterium thermophilum
Length = 357
Score = 52.0 bits (119), Expect = 2e-05
Identities = 46/152 (30%), Positives = 75/152 (49%), Gaps = 4/152 (2%)
Frame = +3
Query: 66 VVDILGDEMTRIIWDLIKEKLILPFLDIELHV--YDLGMENRDKTDDQVTIDCAEAIKKY 239
+V + GD+ + + + L + + LH+ YDL +ENR T ++V + A A++++
Sbjct: 7 IVVLEGDQTGQELLEEAVRLLSPDVIGLPLHLVRYDLSLENRRATSNRVVYEAAAAMREH 66
Query: 240 NVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVT--GWD 413
G+K ATITP E R + SPN +R + GTV + +P + T G
Sbjct: 67 GYGLKAATITP-EGRGDV-------GSPNAILRREIDGTVILRT--GRPLPGVETIGGIT 116
Query: 414 KPIIIGRHAHADQYKATDFVVPGAGTLEIIFK 509
PI + R A D Y+A ++ G G E F+
Sbjct: 117 APIAVVRMATEDAYEAKEW-REGEGDEERAFR 147
>UniRef50_Q40658 Cluster: Isocitrate dehydrogenase; n=1; Oryza
sativa|Rep: Isocitrate dehydrogenase - Oryza sativa
(Rice)
Length = 61
Score = 44.0 bits (99), Expect = 0.005
Identities = 17/26 (65%), Positives = 22/26 (84%)
Frame = +3
Query: 81 GDEMTRIIWDLIKEKLILPFLDIELH 158
GDEMTRI W IK+KLI PFLD++++
Sbjct: 36 GDEMTRIFWQSIKDKLIFPFLDLDIN 61
>UniRef50_A0C1D3 Cluster: Chromosome undetermined scaffold_141,
whole genome shotgun sequence; n=1; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_141,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 490
Score = 35.5 bits (78), Expect = 1.7
Identities = 24/91 (26%), Positives = 41/91 (45%), Gaps = 3/91 (3%)
Frame = +3
Query: 486 GTLEIIFKPESGEAIKHVVHEYKGAGV---ALAMFNTDASIIDFAHSSFKFALDRKYPLY 656
G +E KP +K VH +L++ ++ I + H SFK L +
Sbjct: 71 GFIEEDGKPPETTCLKLAVHRLDNTPQIIQSLSIITSNNIINQWRHYSFKLPLPKLNNQD 130
Query: 657 LSTKNTILKKYDGRFKDIFQDIYDREYKKQF 749
+STKN ++ Y+G + F+ R++K F
Sbjct: 131 VSTKNQKIRAYNGSYSINFESTQQRDFKYVF 161
>UniRef50_Q5E609 Cluster: Putative uncharacterized protein; n=1;
Vibrio fischeri ES114|Rep: Putative uncharacterized
protein - Vibrio fischeri (strain ATCC 700601 / ES114)
Length = 326
Score = 35.1 bits (77), Expect = 2.2
Identities = 16/46 (34%), Positives = 24/46 (52%), Gaps = 2/46 (4%)
Frame = +3
Query: 162 YDLGMENRDKTDDQVTIDCA--EAIKKYNVGIKCATITPDEKRVEE 293
+ G + DK + +DC+ KYN+ +KCAT + DEK E
Sbjct: 86 FSQGFKYEDKVNPPKDVDCSVYHDYAKYNIEVKCATFSDDEKLKSE 131
>UniRef50_A4WT53 Cluster: Sensor protein; n=3; Rhodobacter
sphaeroides|Rep: Sensor protein - Rhodobacter
sphaeroides ATCC 17025
Length = 890
Score = 34.7 bits (76), Expect = 2.9
Identities = 17/49 (34%), Positives = 28/49 (57%)
Frame = +3
Query: 423 IIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEAIKHVVHEYKGAGVA 569
I+G AHAD + +F+ GAG +++ KP + A+ V ++ G G A
Sbjct: 716 IVGATAHADPDRVPEFL--GAGMNDVLVKPITRSALFRAVRQFAGCGQA 762
>UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Thermoproteaceae|Rep: 3-isopropylmalate dehydrogenase -
Pyrobaculum aerophilum
Length = 290
Score = 34.7 bits (76), Expect = 2.9
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 2/97 (2%)
Frame = +3
Query: 474 VPGAGTLEIIFKPESGEAIKHVVHEYKGAGVALAM-FNTDASIIDFAHSSFKFALDRKYP 650
VP ++ +F E+ E + +V EYK VA+A+ T+ A + K+A R+
Sbjct: 69 VPAVREIDCVFVRENVEDV-YVGAEYKVGDVAIALKVITEKGTRRVARMARKYAEMRRRR 127
Query: 651 LYLSTKNTILKKYDGRFKDI-FQDIYDREYKKQFEDA 758
+ + K +L+ DG F+DI +++ E + + DA
Sbjct: 128 VTIVHKANVLRVVDGFFRDIALEELKGLEVDQMYVDA 164
>UniRef50_Q0SU98 Cluster: DNA/RNA helicase, SNF2; n=2; Clostridium
perfringens|Rep: DNA/RNA helicase, SNF2 - Clostridium
perfringens (strain SM101 / Type A)
Length = 1069
Score = 33.9 bits (74), Expect = 5.1
Identities = 28/143 (19%), Positives = 66/143 (46%), Gaps = 2/143 (1%)
Frame = -1
Query: 455 VLISMSMTSNDDGFVPPCYKSRYILANNSLPENSTTKNITDGPIRAFPHFLQF-KFFNSL 279
V +++++ +GF+ +K I+ NNS +N+ R +++ K F
Sbjct: 265 VPVALTLKEGKEGFILSHHKKFPIILNNSGDVMFFDRNLYLPRKRQLEYYIPIHKLFLKN 324
Query: 278 LIRSYGRTFDAHIVFLYGLSTINCNLIISL-ITIFHTQVVDM*FNVQERKNQLFFDKIPD 102
+Y ++ + L L I+ N+++ I +F +++ FN+ + K +++ + D
Sbjct: 325 NTITYKKSLENLRSLLEELKNISKNIVLDENIRVFKEKLMKTTFNLYKNKEKVYCNVKID 384
Query: 101 YSGHFITKDVNNRSSLYFRHIVS 33
Y G+ I + + + + R + S
Sbjct: 385 YCGYIIDLIRDEKDNSFLRDLKS 407
>UniRef50_UPI0000498AD5 Cluster: hypothetical membrane-spanning
protein; n=1; Entamoeba histolytica HM-1:IMSS|Rep:
hypothetical membrane-spanning protein - Entamoeba
histolytica HM-1:IMSS
Length = 453
Score = 33.1 bits (72), Expect = 8.9
Identities = 30/127 (23%), Positives = 57/127 (44%), Gaps = 3/127 (2%)
Frame = -1
Query: 551 VLMNYMFYCLTRFRFEDYFKSTSTWDNKVSCF--VLISMSMTSNDDGFVP-PCYKSRYIL 381
+L N +F + Y KS+S V+ ++ ++ + F+ P Y R +L
Sbjct: 24 LLKNDIFGYEKEIHYPIYKKSSSPIQQSVNLTQQIVNENTIPQSVKSFIQTPFYLERSVL 83
Query: 380 ANNSLPENSTTKNITDGPIRAFPHFLQFKFFNSLLIRSYGRTFDAHIVFLYGLSTINCNL 201
+ ++ + + P+R +F Q F N ++ Y R +D + +Y LST+ C +
Sbjct: 84 IGLLISWDTFSSFLLFTPLRIISYFYQLIFLNEKVVIHYKRIYD---ILMY-LSTLFCVI 139
Query: 200 IISLITI 180
II + I
Sbjct: 140 IIYQVDI 146
>UniRef50_Q142V0 Cluster: Putative uncharacterized protein; n=1;
Burkholderia xenovorans LB400|Rep: Putative
uncharacterized protein - Burkholderia xenovorans
(strain LB400)
Length = 274
Score = 33.1 bits (72), Expect = 8.9
Identities = 27/102 (26%), Positives = 44/102 (43%)
Frame = +3
Query: 60 GPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKY 239
G + GD M E+LI P LD + ++ T D + +D A Y
Sbjct: 28 GSALSFRGDRMDAKREASFFERLIEPMLDQLRRI--ASTTRKEYTVDDLKVDAFIAANDY 85
Query: 240 NVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFR 365
+ + P++++++E LKK+WK+ G N T FR
Sbjct: 86 QQELG-VELEPEDEKLQEAVLKKLWKA-FGKFANRTLRTAFR 125
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 854,133,197
Number of Sequences: 1657284
Number of extensions: 18085004
Number of successful extensions: 50167
Number of sequences better than 10.0: 25
Number of HSP's better than 10.0 without gapping: 47704
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 50134
length of database: 575,637,011
effective HSP length: 100
effective length of database: 409,908,611
effective search space used: 73373641369
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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