Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fcaL-P09_F_B13
(863 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
AF338230-1|AAK25791.1| 1278|Homo sapiens Niemann-Pick disease C1... 157 6e-38
AF157379-1|AAD48006.1| 1278|Homo sapiens Niemann-Pick C1 protein... 157 6e-38
AF002020-1|AAB63982.1| 1278|Homo sapiens Niemann-Pick C disease ... 157 6e-38
AB209048-1|BAD92285.1| 1289|Homo sapiens Niemann-Pick disease, t... 156 9e-38
BC063302-1|AAH63302.1| 1278|Homo sapiens Niemann-Pick disease, t... 155 1e-37
BC117178-1|AAI17179.1| 1332|Homo sapiens NPC1L1 protein protein. 102 1e-21
AY515256-1|AAS56939.1| 1332|Homo sapiens NPC1L1 splice variant p... 102 1e-21
AY437865-1|AAR97886.1| 1332|Homo sapiens Niemann-Pick C1-like 1 ... 102 1e-21
AF192523-1|AAF20397.1| 724|Homo sapiens truncated Niemann-Pick ... 102 1e-21
AF192522-1|AAF20396.1| 1359|Homo sapiens Niemann-Pick C1-like pr... 102 1e-21
>AF338230-1|AAK25791.1| 1278|Homo sapiens Niemann-Pick disease C1
protein protein.
Length = 1278
Score = 157 bits (380), Expect = 6e-38
Identities = 69/192 (35%), Positives = 107/192 (55%), Gaps = 6/192 (3%)
Frame = +1
Query: 301 CIWYGVCANSTEHKMVNCFYDGPAKPIEEKAMKIIEQYCPEIAKGGYS-CCNYEQLNQLK 477
C+WYG C + K NC Y GP KP+ + ++++ CP G S CC+ QL LK
Sbjct: 25 CVWYGECGIAYGDKRYNCEYSGPPKPLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLK 84
Query: 478 VNIALAENLLGRCPTCFQNFLKPICGMACAVDQSKYLKPVKTEQF-----NGTHRRISEI 642
N+ L L RCP+CF N L C + C+ QS++L TE + N T + E+
Sbjct: 85 DNLQLPLQFLSRCPSCFYNLLNLFCELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKEL 144
Query: 643 DYYLSKTFMDGIYNSCSEVKLTSTNERSIKVMCGQWGDACSAQRWFDNMGDASNYQVPFX 822
YY+ ++F + +YN+C +V+ S+N++++ ++CG+ DAC+A W + M + N Q PF
Sbjct: 145 QYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGKDADACNATNWIEYMFNKDNGQAPFT 204
Query: 823 INYKATDVPVDG 858
I +D PV G
Sbjct: 205 ITPVFSDFPVHG 216
>AF157379-1|AAD48006.1| 1278|Homo sapiens Niemann-Pick C1 protein
protein.
Length = 1278
Score = 157 bits (380), Expect = 6e-38
Identities = 69/192 (35%), Positives = 107/192 (55%), Gaps = 6/192 (3%)
Frame = +1
Query: 301 CIWYGVCANSTEHKMVNCFYDGPAKPIEEKAMKIIEQYCPEIAKGGYS-CCNYEQLNQLK 477
C+WYG C + K NC Y GP KP+ + ++++ CP G S CC+ QL LK
Sbjct: 25 CVWYGECGIAYGDKRYNCEYSGPPKPLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLK 84
Query: 478 VNIALAENLLGRCPTCFQNFLKPICGMACAVDQSKYLKPVKTEQF-----NGTHRRISEI 642
N+ L L RCP+CF N L C + C+ QS++L TE + N T + E+
Sbjct: 85 DNLQLPLQFLSRCPSCFYNLLNLFCELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKEL 144
Query: 643 DYYLSKTFMDGIYNSCSEVKLTSTNERSIKVMCGQWGDACSAQRWFDNMGDASNYQVPFX 822
YY+ ++F + +YN+C +V+ S+N++++ ++CG+ DAC+A W + M + N Q PF
Sbjct: 145 QYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGKDADACNATNWIEYMFNKDNGQAPFT 204
Query: 823 INYKATDVPVDG 858
I +D PV G
Sbjct: 205 ITPVFSDFPVHG 216
>AF002020-1|AAB63982.1| 1278|Homo sapiens Niemann-Pick C disease
protein protein.
Length = 1278
Score = 157 bits (380), Expect = 6e-38
Identities = 69/192 (35%), Positives = 107/192 (55%), Gaps = 6/192 (3%)
Frame = +1
Query: 301 CIWYGVCANSTEHKMVNCFYDGPAKPIEEKAMKIIEQYCPEIAKGGYS-CCNYEQLNQLK 477
C+WYG C + K NC Y GP KP+ + ++++ CP G S CC+ QL LK
Sbjct: 25 CVWYGECGIAYGDKRYNCEYSGPPKPLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLK 84
Query: 478 VNIALAENLLGRCPTCFQNFLKPICGMACAVDQSKYLKPVKTEQF-----NGTHRRISEI 642
N+ L L RCP+CF N L C + C+ QS++L TE + N T + E+
Sbjct: 85 DNLQLPLQFLSRCPSCFYNLLNLFCELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKEL 144
Query: 643 DYYLSKTFMDGIYNSCSEVKLTSTNERSIKVMCGQWGDACSAQRWFDNMGDASNYQVPFX 822
YY+ ++F + +YN+C +V+ S+N++++ ++CG+ DAC+A W + M + N Q PF
Sbjct: 145 QYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGKDADACNATNWIEYMFNKDNGQAPFT 204
Query: 823 INYKATDVPVDG 858
I +D PV G
Sbjct: 205 ITPVFSDFPVHG 216
>AB209048-1|BAD92285.1| 1289|Homo sapiens Niemann-Pick disease, type
C1 variant protein.
Length = 1289
Score = 156 bits (379), Expect = 9e-38
Identities = 69/192 (35%), Positives = 107/192 (55%), Gaps = 6/192 (3%)
Frame = +1
Query: 301 CIWYGVCANSTEHKMVNCFYDGPAKPIEEKAMKIIEQYCPEIAKGGYS-CCNYEQLNQLK 477
C+WYG C + K NC Y GP KP+ + ++++ CP G S CC+ QL LK
Sbjct: 36 CVWYGECGIAYGDKRYNCEYSGPPKPLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLK 95
Query: 478 VNIALAENLLGRCPTCFQNFLKPICGMACAVDQSKYLKPVKTEQF-----NGTHRRISEI 642
N+ L L RCP+CF N L C + C+ QS++L TE + N T + E+
Sbjct: 96 DNLQLPLQFLSRCPSCFYNLLNLFCELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKEL 155
Query: 643 DYYLSKTFMDGIYNSCSEVKLTSTNERSIKVMCGQWGDACSAQRWFDNMGDASNYQVPFX 822
YY+ ++F + +YN+C +V+ S+N++++ ++CG+ DAC+A W + M + N Q PF
Sbjct: 156 QYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGKDADACNATNWIEYMFNKDNGQAPFT 215
Query: 823 INYKATDVPVDG 858
I +D PV G
Sbjct: 216 ITPVFSDFPVRG 227
>BC063302-1|AAH63302.1| 1278|Homo sapiens Niemann-Pick disease, type
C1 protein.
Length = 1278
Score = 155 bits (377), Expect = 1e-37
Identities = 69/192 (35%), Positives = 106/192 (55%), Gaps = 6/192 (3%)
Frame = +1
Query: 301 CIWYGVCANSTEHKMVNCFYDGPAKPIEEKAMKIIEQYCPEIAKGGYS-CCNYEQLNQLK 477
C+WYG C + K NC Y GP KP+ + ++++ CP G S CC+ QL LK
Sbjct: 25 CVWYGECGIAYGDKRYNCEYSGPPKPLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLK 84
Query: 478 VNIALAENLLGRCPTCFQNFLKPICGMACAVDQSKYLKPVKTEQF-----NGTHRRISEI 642
N+ L L RCP+CF N L C + C+ QS++L TE + N T + E+
Sbjct: 85 DNLQLPLQFLSRCPSCFYNLLNLFCELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKEL 144
Query: 643 DYYLSKTFMDGIYNSCSEVKLTSTNERSIKVMCGQWGDACSAQRWFDNMGDASNYQVPFX 822
YY+ + F + +YN+C +V+ S+N++++ ++CG+ DAC+A W + M + N Q PF
Sbjct: 145 QYYVGQGFANAMYNACRDVEAPSSNDKALGLLCGKDADACNATNWIEYMFNKDNGQAPFT 204
Query: 823 INYKATDVPVDG 858
I +D PV G
Sbjct: 205 ITPVFSDFPVHG 216
>BC117178-1|AAI17179.1| 1332|Homo sapiens NPC1L1 protein protein.
Length = 1332
Score = 102 bits (245), Expect = 1e-21
Identities = 53/196 (27%), Positives = 98/196 (50%), Gaps = 11/196 (5%)
Frame = +1
Query: 277 SALAEDGHCIWYGVCANSTEHK-------MVNCFYDGPAKPIEEKAMKIIEQYCPEIAKG 435
+ + + G+C +Y C + E V+C + PA+ I + ++++ CP + G
Sbjct: 25 TTIHQPGYCAFYDECGKNPELSGSLMTLSNVSCLSNTPARKITGDHLILLQKICPRLYTG 84
Query: 436 G--YSCCNYEQLNQLKVNIALAENLLGRCPTCFQNFLKPICGMACAVDQSKYLKPVKTEQ 609
+CC+ +QL L+ ++++ + LL RCP C NF+ C C+ +QS ++ + Q
Sbjct: 85 PNTQACCSAKQLVSLEASLSITKALLTRCPACSDNFVNLHCHNTCSPNQSLFINVTRVAQ 144
Query: 610 FN-GTHRRISEIDYYLSKTFMDGIYNSCSEVKLTSTNERSIKVMCGQWGDA-CSAQRWFD 783
G + + + +F + Y+SCS V++ + ++ MCG +G A C+AQRW +
Sbjct: 145 LGAGQLPAVVAYEAFYQHSFAEQSYDSCSRVRVPAAATLAVGTMCGVYGSALCNAQRWLN 204
Query: 784 NMGDASNYQVPFXINY 831
GD N P I +
Sbjct: 205 FQGDTGNGLAPLDITF 220
>AY515256-1|AAS56939.1| 1332|Homo sapiens NPC1L1 splice variant
protein.
Length = 1332
Score = 102 bits (245), Expect = 1e-21
Identities = 53/196 (27%), Positives = 98/196 (50%), Gaps = 11/196 (5%)
Frame = +1
Query: 277 SALAEDGHCIWYGVCANSTEHK-------MVNCFYDGPAKPIEEKAMKIIEQYCPEIAKG 435
+ + + G+C +Y C + E V+C + PA+ I + ++++ CP + G
Sbjct: 25 TTIHQPGYCAFYDECGKNPELSGSLMTLSNVSCLSNTPARKITGDHLILLQKICPRLYTG 84
Query: 436 G--YSCCNYEQLNQLKVNIALAENLLGRCPTCFQNFLKPICGMACAVDQSKYLKPVKTEQ 609
+CC+ +QL L+ ++++ + LL RCP C NF+ C C+ +QS ++ + Q
Sbjct: 85 PNTQACCSAKQLVSLEASLSITKALLTRCPACSDNFVNLHCHNTCSPNQSLFINVTRVAQ 144
Query: 610 FN-GTHRRISEIDYYLSKTFMDGIYNSCSEVKLTSTNERSIKVMCGQWGDA-CSAQRWFD 783
G + + + +F + Y+SCS V++ + ++ MCG +G A C+AQRW +
Sbjct: 145 LGAGQLPAVVAYEAFYQHSFAEQSYDSCSRVRVPAAATLAVGTMCGVYGSALCNAQRWLN 204
Query: 784 NMGDASNYQVPFXINY 831
GD N P I +
Sbjct: 205 FQGDTGNGLAPLDITF 220
>AY437865-1|AAR97886.1| 1332|Homo sapiens Niemann-Pick C1-like 1
protein.
Length = 1332
Score = 102 bits (245), Expect = 1e-21
Identities = 53/196 (27%), Positives = 98/196 (50%), Gaps = 11/196 (5%)
Frame = +1
Query: 277 SALAEDGHCIWYGVCANSTEHK-------MVNCFYDGPAKPIEEKAMKIIEQYCPEIAKG 435
+ + + G+C +Y C + E V+C + PA+ I + ++++ CP + G
Sbjct: 25 TTIHQPGYCAFYDECGKNPELSGSLMTLSNVSCLSNTPARKITGDHLILLQKICPRLYTG 84
Query: 436 G--YSCCNYEQLNQLKVNIALAENLLGRCPTCFQNFLKPICGMACAVDQSKYLKPVKTEQ 609
+CC+ +QL L+ ++++ + LL RCP C NF+ C C+ +QS ++ + Q
Sbjct: 85 PNTQACCSAKQLVSLEASLSITKALLTRCPACSDNFVNLHCHNTCSPNQSLFINVTRVAQ 144
Query: 610 FN-GTHRRISEIDYYLSKTFMDGIYNSCSEVKLTSTNERSIKVMCGQWGDA-CSAQRWFD 783
G + + + +F + Y+SCS V++ + ++ MCG +G A C+AQRW +
Sbjct: 145 LGAGQLPAVVAYEAFYQHSFAEQSYDSCSRVRVPAAATLAVGTMCGVYGSALCNAQRWLN 204
Query: 784 NMGDASNYQVPFXINY 831
GD N P I +
Sbjct: 205 FQGDTGNGLAPLDITF 220
>AF192523-1|AAF20397.1| 724|Homo sapiens truncated Niemann-Pick
C1-like protein 1 protein.
Length = 724
Score = 102 bits (245), Expect = 1e-21
Identities = 53/196 (27%), Positives = 98/196 (50%), Gaps = 11/196 (5%)
Frame = +1
Query: 277 SALAEDGHCIWYGVCANSTEHK-------MVNCFYDGPAKPIEEKAMKIIEQYCPEIAKG 435
+ + + G+C +Y C + E V+C + PA+ I + ++++ CP + G
Sbjct: 25 TTIHQPGYCAFYDECGKNPELSGSLMTLSNVSCLSNTPARKITGDHLILLQKICPRLYTG 84
Query: 436 G--YSCCNYEQLNQLKVNIALAENLLGRCPTCFQNFLKPICGMACAVDQSKYLKPVKTEQ 609
+CC+ +QL L+ ++++ + LL RCP C NF+ C C+ +QS ++ + Q
Sbjct: 85 PNTQACCSAKQLVSLEASLSITKALLTRCPACSDNFVNLHCHNTCSPNQSLFINVTRVAQ 144
Query: 610 FN-GTHRRISEIDYYLSKTFMDGIYNSCSEVKLTSTNERSIKVMCGQWGDA-CSAQRWFD 783
G + + + +F + Y+SCS V++ + ++ MCG +G A C+AQRW +
Sbjct: 145 LGAGQLPAVVAYEAFYQHSFAEQSYDSCSRVRVPAAATLAVGTMCGVYGSALCNAQRWLN 204
Query: 784 NMGDASNYQVPFXINY 831
GD N P I +
Sbjct: 205 FQGDTGNGLAPLDITF 220
>AF192522-1|AAF20396.1| 1359|Homo sapiens Niemann-Pick C1-like
protein 1 protein.
Length = 1359
Score = 102 bits (245), Expect = 1e-21
Identities = 53/196 (27%), Positives = 98/196 (50%), Gaps = 11/196 (5%)
Frame = +1
Query: 277 SALAEDGHCIWYGVCANSTEHK-------MVNCFYDGPAKPIEEKAMKIIEQYCPEIAKG 435
+ + + G+C +Y C + E V+C + PA+ I + ++++ CP + G
Sbjct: 25 TTIHQPGYCAFYDECGKNPELSGSLMTLSNVSCLSNTPARKITGDHLILLQKICPRLYTG 84
Query: 436 G--YSCCNYEQLNQLKVNIALAENLLGRCPTCFQNFLKPICGMACAVDQSKYLKPVKTEQ 609
+CC+ +QL L+ ++++ + LL RCP C NF+ C C+ +QS ++ + Q
Sbjct: 85 PNTQACCSAKQLVSLEASLSITKALLTRCPACSDNFVNLHCHNTCSPNQSLFINVTRVAQ 144
Query: 610 FN-GTHRRISEIDYYLSKTFMDGIYNSCSEVKLTSTNERSIKVMCGQWGDA-CSAQRWFD 783
G + + + +F + Y+SCS V++ + ++ MCG +G A C+AQRW +
Sbjct: 145 LGAGQLPAVVAYEAFYQHSFAEQSYDSCSRVRVPAAATLAVGTMCGVYGSALCNAQRWLN 204
Query: 784 NMGDASNYQVPFXINY 831
GD N P I +
Sbjct: 205 FQGDTGNGLAPLDITF 220
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 115,024,094
Number of Sequences: 237096
Number of extensions: 2412232
Number of successful extensions: 5237
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5035
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5212
length of database: 76,859,062
effective HSP length: 89
effective length of database: 55,757,518
effective search space used: 11039988564
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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