Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fcaL-P08_F_D03
(863 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P48735 Cluster: Isocitrate dehydrogenase [NADP], mitoch... 379 e-104
UniRef50_Q8LPJ5 Cluster: Isocitrate dehydrogenase-like protein; ... 367 e-100
UniRef50_Q9SRZ6 Cluster: F12P19.10 protein; n=26; cellular organ... 352 6e-96
UniRef50_Q0CXI1 Cluster: Isocitrate dehydrogenase, mitochondrial... 343 3e-93
UniRef50_A2WMU2 Cluster: Putative uncharacterized protein; n=5; ... 319 5e-86
UniRef50_A5N5L9 Cluster: Idh; n=2; Bacteria|Rep: Idh - Clostridi... 295 9e-79
UniRef50_A5ZVX5 Cluster: Putative uncharacterized protein; n=1; ... 288 1e-76
UniRef50_A2XVE4 Cluster: Putative uncharacterized protein; n=2; ... 174 2e-54
UniRef50_UPI0000F1EC8D Cluster: PREDICTED: similar to Isocitrate... 211 2e-53
UniRef50_Q4VCC2 Cluster: Isocitrate dehydrogenase; n=4; Eukaryot... 109 7e-23
UniRef50_Q2K7T8 Cluster: NADP-dependent isocitrate dehydrogenase... 108 2e-22
UniRef50_A3JDN6 Cluster: Isocitrate dehydrogenase; n=5; Gammapro... 108 2e-22
UniRef50_Q00WM7 Cluster: COG0538: Isocitrate dehydrogenases; n=3... 107 4e-22
UniRef50_A3K670 Cluster: NADP-dependent isocitrate dehydrogenase... 97 5e-19
UniRef50_Q5DBI8 Cluster: SJCHGC09598 protein; n=1; Schistosoma j... 85 2e-15
UniRef50_A4VDP7 Cluster: Putative uncharacterized protein; n=1; ... 56 1e-06
UniRef50_Q67N12 Cluster: 3-isopropylmalate dehydrogenase; n=5; B... 51 3e-05
UniRef50_Q5E609 Cluster: Putative uncharacterized protein; n=1; ... 35 2.3
UniRef50_A4WT53 Cluster: Sensor protein; n=3; Rhodobacter sphaer... 35 3.1
UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5; T... 35 3.1
UniRef50_UPI0000498AD5 Cluster: hypothetical membrane-spanning p... 33 9.3
UniRef50_A0C1D3 Cluster: Chromosome undetermined scaffold_141, w... 33 9.3
>UniRef50_P48735 Cluster: Isocitrate dehydrogenase [NADP],
mitochondrial precursor (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH); n=493;
cellular organisms|Rep: Isocitrate dehydrogenase [NADP],
mitochondrial precursor (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) - Homo
sapiens (Human)
Length = 452
Score = 379 bits (933), Expect = e-104
Identities = 171/256 (66%), Positives = 199/256 (77%), Gaps = 1/256 (0%)
Frame = +3
Query: 99 MTXIIWDXXXXXXXXPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCATIT 278
MT IIW P +DI+L +DLG+ NRD+TDDQVTID A A +KY+V +KCATIT
Sbjct: 58 MTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATIT 117
Query: 279 PDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHAD 458
PDE RVEEFKLKKMWKSPNGTIRNILGGTVFRE IICKNIPRLV GW KPI IGRHAH D
Sbjct: 118 PDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGD 177
Query: 459 QYKATDFVVPGAGTLEIIFKPESGEAIKH-VVHEYKGAGVALAMFNTDASIIDFAHSSFK 635
QYKATDFV AGT +++F P+ G +K V+ + GV + M+NTD SI FAHS F+
Sbjct: 178 QYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQ 237
Query: 636 FALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDREYXKQFEDAGIWYEHRLIDDMVAYA 815
+A+ +K+PLY+STKNTILK YDGRFKDIFQ+I+D+ Y F+ IWYEHRLIDDMVA
Sbjct: 238 YAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQV 297
Query: 816 MKSXGGFVWACKNYDG 863
+KS GGFVWACKNYDG
Sbjct: 298 LKSSGGFVWACKNYDG 313
>UniRef50_Q8LPJ5 Cluster: Isocitrate dehydrogenase-like protein;
n=6; core eudicotyledons|Rep: Isocitrate
dehydrogenase-like protein - Arabidopsis thaliana
(Mouse-ear cress)
Length = 485
Score = 367 bits (903), Expect = e-100
Identities = 166/256 (64%), Positives = 202/256 (78%), Gaps = 1/256 (0%)
Frame = +3
Query: 99 MTXIIWDXXXXXXXXPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCATIT 278
MT +IW P+LD+++ +DLG+ NRD TDD+VT++ AEA KYNV IKCATIT
Sbjct: 90 MTRVIWSMIKEKLILPYLDLDIKYFDLGILNRDATDDKVTVESAEAALKYNVAIKCATIT 149
Query: 279 PDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHAD 458
PDE RV+EF LK MW+SPNGTIRNIL GTVFRE I+C NIPRLV GW+KPI IGRHA D
Sbjct: 150 PDEGRVKEFGLKSMWRSPNGTIRNILDGTVFREPIMCSNIPRLVPGWEKPICIGRHAFGD 209
Query: 459 QYKATDFVVPGAGTLEIIFKPESGEA-IKHVVHEYKGAGVALAMFNTDASIIDFAHSSFK 635
QY+ATD V+ G G L+++F PE G A ++ V+++KG GVALAM+N D SI FA SS
Sbjct: 210 QYRATDTVIKGPGKLKMVFVPEDGNAPVELDVYDFKGPGVALAMYNVDESIRAFAESSMA 269
Query: 636 FALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDREYXKQFEDAGIWYEHRLIDDMVAYA 815
AL +K+PLYLSTKNTILKKYDGRFKDIFQ++Y+ + ++FE+ IWYEHRLIDDMVAYA
Sbjct: 270 MALTKKWPLYLSTKNTILKKYDGRFKDIFQEVYEANWKQKFEEHSIWYEHRLIDDMVAYA 329
Query: 816 MKSXGGFVWACKNYDG 863
+KS GG+VWACKNYDG
Sbjct: 330 VKSEGGYVWACKNYDG 345
>UniRef50_Q9SRZ6 Cluster: F12P19.10 protein; n=26; cellular
organisms|Rep: F12P19.10 protein - Arabidopsis thaliana
(Mouse-ear cress)
Length = 410
Score = 352 bits (866), Expect = 6e-96
Identities = 159/255 (62%), Positives = 195/255 (76%)
Frame = +3
Query: 99 MTXIIWDXXXXXXXXPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCATIT 278
MT +IW PF+++++ +DLG+ +RD TDD+VTI+ AEA KKYNV IKCATIT
Sbjct: 20 MTRVIWKSIKDKLITPFVELDIKYFDLGLPHRDATDDKVTIESAEATKKYNVAIKCATIT 79
Query: 279 PDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHAD 458
PDE RV EF LK+MW+SPNGTIRNIL GTVFRE IICKN+P+LV GW KPI IGRHA D
Sbjct: 80 PDEGRVTEFGLKQMWRSPNGTIRNILNGTVFREPIICKNVPKLVPGWTKPICIGRHAFGD 139
Query: 459 QYKATDFVVPGAGTLEIIFKPESGEAIKHVVHEYKGAGVALAMFNTDASIIDFAHSSFKF 638
QY+ATD V+ G G L + F+ + G+ V GVA+AM+NTD SI FA +S
Sbjct: 140 QYRATDAVIKGPGKLTMTFEGKDGKTETEVFTFTGEGGVAMAMYNTDESIRAFADASMNT 199
Query: 639 ALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDREYXKQFEDAGIWYEHRLIDDMVAYAM 818
A ++K+PLYLSTKNTILKKYDGRFKDIFQ++Y+ + +++ AGIWYEHRLIDDMVAYA+
Sbjct: 200 AYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEASWKSKYDAAGIWYEHRLIDDMVAYAL 259
Query: 819 KSXGGFVWACKNYDG 863
KS GG+VWACKNYDG
Sbjct: 260 KSEGGYVWACKNYDG 274
>UniRef50_Q0CXI1 Cluster: Isocitrate dehydrogenase, mitochondrial;
n=2; Eurotiomycetidae|Rep: Isocitrate dehydrogenase,
mitochondrial - Aspergillus terreus (strain NIH 2624)
Length = 466
Score = 343 bits (844), Expect = 3e-93
Identities = 158/229 (68%), Positives = 188/229 (82%), Gaps = 1/229 (0%)
Frame = +3
Query: 180 GMENRDKTDDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILG 359
G+E RD+TDD+VT++ AEAIKKY VG+KCATITPDE RVEEFKLKKMW SPNGTIRNILG
Sbjct: 101 GIEYRDQTDDKVTVEAAEAIKKYGVGVKCATITPDEARVEEFKLKKMWLSPNGTIRNILG 160
Query: 360 GTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEAI 539
GTVFRE I+ IPRLV GW KPIIIGRHA DQY+ATD V+PG G LE+++ P +G+
Sbjct: 161 GTVFREPIVIPAIPRLVPGWTKPIIIGRHAFGDQYRATDRVIPGPGKLELVYTPANGQPE 220
Query: 540 KHVVHEYK-GAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKD 716
V++++ G GVA++M+NTD SI FAHSSFK AL + PLY+STKNTILK+YDGRFKD
Sbjct: 221 SVQVYDFQSGGGVAMSMYNTDDSIRGFAHSSFKMALLKGLPLYMSTKNTILKRYDGRFKD 280
Query: 717 IFQDIYDREYXKQFEDAGIWYEHRLIDDMVAYAMKSXGGFVWACKNYDG 863
IFQ+IY+ EY K+F+ GIWYEHRLIDDMVA +KS GGF+ A KNYDG
Sbjct: 281 IFQEIYEAEYKKEFDAKGIWYEHRLIDDMVAQMIKSEGGFIMALKNYDG 329
>UniRef50_A2WMU2 Cluster: Putative uncharacterized protein; n=5;
Eukaryota|Rep: Putative uncharacterized protein - Oryza
sativa subsp. indica (Rice)
Length = 475
Score = 319 bits (784), Expect = 5e-86
Identities = 167/292 (57%), Positives = 196/292 (67%), Gaps = 37/292 (12%)
Frame = +3
Query: 99 MTXIIWDXXXXXXXXPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCATIT 278
MT +IW PFLD+++ YDLG+ NRD T D+VTI+ AEA KYNV IKCATIT
Sbjct: 45 MTRVIWKWIKDKLIFPFLDLDIKYYDLGLPNRDATGDKVTIESAEATLKYNVAIKCATIT 104
Query: 279 P------------------DEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPR 404
P DE RV+EF L MWKSPNGTIRNIL GTVFRE IICKNIPR
Sbjct: 105 PVLDTQFKFDFGRTIHEPTDEGRVKEFNLSAMWKSPNGTIRNILNGTVFREPIICKNIPR 164
Query: 405 LVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEAIKHVVHEYKGA-GVAL 581
LV GW KPI IGRHA DQY+ATD V+ G G L+++F E I+ V + GA GVAL
Sbjct: 165 LVPGWIKPICIGRHAFGDQYRATDTVIKGPGKLKLVFDGRE-EQIELDVFNFTGAGGVAL 223
Query: 582 AMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDREYXKQFE 761
+M+NTD SI FA +S A +++PLYLSTKNTILKKYDGRFKDIFQ+ Y+ ++ +F+
Sbjct: 224 SMYNTDESIWAFAEASMNMAYQKRWPLYLSTKNTILKKYDGRFKDIFQENYETKWRAKFD 283
Query: 762 DAGIW------------------YEHRLIDDMVAYAMKSXGGFVWACKNYDG 863
DAGIW YEHRLIDDMVAYA+KS GG+VWACKNYDG
Sbjct: 284 DAGIWNMEPYFPPLCPNHFCCGRYEHRLIDDMVAYALKSEGGYVWACKNYDG 335
>UniRef50_A5N5L9 Cluster: Idh; n=2; Bacteria|Rep: Idh - Clostridium
kluyveri DSM 555
Length = 401
Score = 295 bits (724), Expect = 9e-79
Identities = 134/255 (52%), Positives = 174/255 (68%)
Frame = +3
Query: 99 MTXIIWDXXXXXXXXPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCATIT 278
MT IIW P++D++ YDLG+ R++T+D++TI+ A AIKKY VG+KCATIT
Sbjct: 19 MTRIIWKMIKELLLEPYIDLKTEYYDLGLVKRNETNDEITIEAANAIKKYGVGVKCATIT 78
Query: 279 PDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHAD 458
P+ KRV+E+ LK MWKSPNGTIR IL GTVFR II +I L+ W+KPI + RHA+ D
Sbjct: 79 PNAKRVKEYNLKSMWKSPNGTIRAILDGTVFRTPIIVNSIRPLMRTWEKPITVARHAYGD 138
Query: 459 QYKATDFVVPGAGTLEIIFKPESGEAIKHVVHEYKGAGVALAMFNTDASIIDFAHSSFKF 638
Y+ ++ V G +E++F E GE + +H + G GV + M N D SI FA S F +
Sbjct: 139 VYRDVEYKVEEPGKMELVFTSEKGEETRQTLHVFNGPGVVMGMHNLDKSIESFARSCFNY 198
Query: 639 ALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDREYXKQFEDAGIWYEHRLIDDMVAYAM 818
ALD L+ ++K+TI K YD RFKDIFQ+IYD EY +F DAGI Y + LIDD VA +
Sbjct: 199 ALDMNQNLWFASKDTISKTYDHRFKDIFQEIYDTEYDAKFNDAGIEYFYTLIDDAVARVV 258
Query: 819 KSXGGFVWACKNYDG 863
KS GGF+WACKNYDG
Sbjct: 259 KSEGGFIWACKNYDG 273
>UniRef50_A5ZVX5 Cluster: Putative uncharacterized protein; n=1;
Ruminococcus obeum ATCC 29174|Rep: Putative
uncharacterized protein - Ruminococcus obeum ATCC 29174
Length = 417
Score = 288 bits (706), Expect = 1e-76
Identities = 130/255 (50%), Positives = 172/255 (67%)
Frame = +3
Query: 99 MTXIIWDXXXXXXXXPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCATIT 278
MT I+W PF+D+ YDLG+ R++TDDQVTID AEA KKY V +KCATIT
Sbjct: 33 MTRILWKMIKDELLLPFIDLNTEYYDLGLNYRNETDDQVTIDAAEATKKYGVAVKCATIT 92
Query: 279 PDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHAD 458
P+ R++E+ LKKM+KSPNGTIR IL GTVFR I+ K I V W KPI + RHA+ D
Sbjct: 93 PNHARMDEYDLKKMYKSPNGTIRAILDGTVFRAPIVVKGIEPCVRNWKKPITLARHAYGD 152
Query: 459 QYKATDFVVPGAGTLEIIFKPESGEAIKHVVHEYKGAGVALAMFNTDASIIDFAHSSFKF 638
YK T+ + G +E+++ E GE + +V E+K GVA+ M N ASI FA S F +
Sbjct: 153 IYKNTEMYIDKPGKVELVYTSEDGEEKRSLVQEFKAPGVAMGMHNMTASIESFARSCFNY 212
Query: 639 ALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDREYXKQFEDAGIWYEHRLIDDMVAYAM 818
ALD K ++ K+TI K YD +FK++FQ ++D E+ +FE+AG+ Y + LIDD+VA M
Sbjct: 213 ALDTKQDVWFGAKDTISKTYDAKFKEVFQTVFDTEFKDRFEEAGLTYFYSLIDDIVARVM 272
Query: 819 KSXGGFVWACKNYDG 863
K+ GGF+WACKNYDG
Sbjct: 273 KAEGGFIWACKNYDG 287
>UniRef50_A2XVE4 Cluster: Putative uncharacterized protein; n=2;
Oryza sativa|Rep: Putative uncharacterized protein -
Oryza sativa subsp. indica (Rice)
Length = 371
Score = 174 bits (423), Expect(2) = 2e-54
Identities = 76/119 (63%), Positives = 96/119 (80%)
Frame = +3
Query: 507 IIFKPESGEAIKHVVHEYKGAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTI 686
I+ P+ E ++ V+ +KG GVAL+M+N D SI FA SS AL +K+PLYLSTKNTI
Sbjct: 30 ILSVPDGAEPVELNVYNFKGPGVALSMYNVDESIRAFAESSMAMALSKKWPLYLSTKNTI 89
Query: 687 LKKYDGRFKDIFQDIYDREYXKQFEDAGIWYEHRLIDDMVAYAMKSXGGFVWACKNYDG 863
LKKYDGRFKDIFQ++Y+ ++ ++FE+ IWYEHRLIDDMVAYA+KS GG+VWACKNYDG
Sbjct: 90 LKKYDGRFKDIFQEVYEEKWKEKFEENSIWYEHRLIDDMVAYAVKSEGGYVWACKNYDG 148
Score = 81.0 bits (191), Expect = 4e-14
Identities = 36/57 (63%), Positives = 46/57 (80%)
Frame = +3
Query: 603 SIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDREYXKQFEDAGI 773
SI FA SS AL +K+PLYLSTKNTILKKYDGRFKDIFQ++Y+ ++ ++FE+ I
Sbjct: 158 SIRAFAESSMAMALSKKWPLYLSTKNTILKKYDGRFKDIFQEVYEEKWKEKFEENSI 214
Score = 62.1 bits (144), Expect(2) = 2e-54
Identities = 24/32 (75%), Positives = 30/32 (93%)
Frame = +3
Query: 318 MWKSPNGTIRNILGGTVFREAIICKNIPRLVT 413
MW+SPNGTIRNIL GTVFRE I+CKN+PR+++
Sbjct: 1 MWRSPNGTIRNILNGTVFREPILCKNVPRILS 32
>UniRef50_UPI0000F1EC8D Cluster: PREDICTED: similar to Isocitrate
dehydrogenase 1 (NADP+), soluble; n=2; Danio rerio|Rep:
PREDICTED: similar to Isocitrate dehydrogenase 1
(NADP+), soluble - Danio rerio
Length = 206
Score = 211 bits (515), Expect = 2e-53
Identities = 92/121 (76%), Positives = 106/121 (87%)
Frame = +3
Query: 99 MTXIIWDXXXXXXXXPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCATIT 278
MT +IW+ P+L+++LH YDLGMENRD TDD+VT++ AEA+++YNVGIKCATIT
Sbjct: 25 MTRVIWELIKEKLIFPYLELDLHSYDLGMENRDATDDKVTVEAAEAVRRYNVGIKCATIT 84
Query: 279 PDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHAD 458
PDEKRVEEFKLK+MW+SPNGTIRNILGGTVFREAIICKNIPRLV GW KPIIIGRHAH D
Sbjct: 85 PDEKRVEEFKLKQMWRSPNGTIRNILGGTVFREAIICKNIPRLVPGWIKPIIIGRHAHGD 144
Query: 459 Q 461
Q
Sbjct: 145 Q 145
>UniRef50_Q4VCC2 Cluster: Isocitrate dehydrogenase; n=4;
Eukaryota|Rep: Isocitrate dehydrogenase - Saltugilia
latimeri
Length = 158
Score = 109 bits (263), Expect = 7e-23
Identities = 47/70 (67%), Positives = 58/70 (82%)
Frame = +3
Query: 594 TDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDREYXKQFEDAGI 773
TD SI FA +S A ++K+PLYLSTKNTILKKYDGRFKDIFQ++Y++ + ++E AGI
Sbjct: 1 TDESIYSFAEASMTTAYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEKSWKSKYEAAGI 60
Query: 774 WYEHRLIDDM 803
WYEHRLIDDM
Sbjct: 61 WYEHRLIDDM 70
>UniRef50_Q2K7T8 Cluster: NADP-dependent isocitrate dehydrogenase
protein; n=1; Rhizobium etli CFN 42|Rep: NADP-dependent
isocitrate dehydrogenase protein - Rhizobium etli
(strain CFN 42 / ATCC 51251)
Length = 437
Score = 108 bits (260), Expect = 2e-22
Identities = 67/255 (26%), Positives = 128/255 (50%)
Frame = -1
Query: 863 SIIIFAGPDKSTL*FXXXXXXXIN*PVFIPDTSILKLFXVLPVINILKDVFETTIVFLEN 684
++++ AGPD ++ ++ VF+ D L+L +++ L+DV E ++ LE+
Sbjct: 151 AVVVLAGPDVASGPLQGRGDHVVDQTVFVGDPGFLELILEFGLVDFLEDVLEAAVIGLED 210
Query: 683 CILSA*VQRVFSVQSKLE*RMSKVNNRCISVKHSQCYTCTLVLMNYMFYCLTRFRFEDYF 504
+L V R F+ Q+ + +R + V H + + + F E
Sbjct: 211 GVLGRQVDRPFAHQAVHHRGAGEFADRFVEVVHGHGNAGARRVEDLLLDDGAVFTDELDR 270
Query: 503 KSTSTWDNKVSCFVLISMSMTSNDDGFVPPCYKSRYILANNSLPENSTTKNITDGPIRAF 324
+ + +V C VL++ S+T++DD P ++R + A++ L E+ +N++D +RA
Sbjct: 271 QLALAGELEVGCAVLVAESVTADDDRLRPAGNEARNVAADDRLAEDDAAENVSDRAVRAL 330
Query: 323 PHFLQFKFFNSLLIRSYGRTFDAHIVFLYGLSTINCNLIISLITIFHTQVVDM*FNVQER 144
PHFL+ +F ++ IR D VFL G+ ++ +L++ + IF +VV + V+ R
Sbjct: 331 PHFLEIEFLDAGFIRRDRCALDTDAVFLDGVGGVDRHLVVGGVAIFDREVVIVDIEVEIR 390
Query: 143 KNQLXFDKIPDYXGH 99
+QL D++PD H
Sbjct: 391 MDQLILDELPDDACH 405
>UniRef50_A3JDN6 Cluster: Isocitrate dehydrogenase; n=5;
Gammaproteobacteria|Rep: Isocitrate dehydrogenase -
Marinobacter sp. ELB17
Length = 582
Score = 108 bits (260), Expect = 2e-22
Identities = 73/232 (31%), Positives = 116/232 (50%), Gaps = 12/232 (5%)
Frame = +3
Query: 150 LDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCATITPDEKRVE-------EFK 308
L IEL DL E+R T+ QV + EA+KKY VG+K A +T + ++++ E
Sbjct: 36 LAIELIEIDLSAEHRFLTNGQVIFEAIEALKKYGVGVKNAGMTVNREQLDAMLEKHPELS 95
Query: 309 LKKM----WKSPNGTIRNILGGTVFREAIICKNIPRLVTGW-DKPIIIGRHAHADQYKAT 473
++ KSPNG IR +GG + RE I +N+ W D+ I + + +
Sbjct: 96 QSRLDPLATKSPNGAIRKGIGGNITREDIQFQNLRVRKPDWIDRDIDVDTMDNGGIKDSY 155
Query: 474 DFVVPGAGTLEIIFKPESGEAIKHVVHEYKGAGVALAMFNTDASIIDFAHSSFKFALDRK 653
+ + G ++++F +SG ++ + K L N A + +AH F+ A+D K
Sbjct: 156 NELSSSTGVVKLLFVGKSGNPVELHRRDVKKGDPWLLATNDIADVKAWAHRFFQRAIDEK 215
Query: 654 YPLYLSTKNTILKKYDGRFKDIFQDIYDREYXKQFEDAGIWYEHRLIDDMVA 809
YL K+T++ YDG + + IY +EY KQFE GI Y + L+D A
Sbjct: 216 RDAYLGLKDTVIAGYDGVMRAAIEAIYKQEYKKQFEAVGINYYYELVDAQAA 267
>UniRef50_Q00WM7 Cluster: COG0538: Isocitrate dehydrogenases; n=3;
Ostreococcus|Rep: COG0538: Isocitrate dehydrogenases -
Ostreococcus tauri
Length = 429
Score = 107 bits (257), Expect = 4e-22
Identities = 86/268 (32%), Positives = 124/268 (46%), Gaps = 13/268 (4%)
Frame = +3
Query: 99 MTXIIWDXXXXXXXXPFLDIE-LHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCATI 275
MT + D P +D+ +DL +NRD T+D+V D EA K+ K T+
Sbjct: 39 MTAYVMDLIRSRWIEPRVDVGGWETFDLRAKNRDDTEDRVLRDVIEAGKRIKAIFKEPTV 98
Query: 276 TPDEKRVEEFKLKKMWKSPNGTIRNILGG-TVFREAIICKNIPRLVTGWDKPIIIGRHAH 452
TP +V+ L+K W SPNG +R G T+ R+ I +I + G+ KP++ RHA
Sbjct: 99 TPTADQVKRLGLRKSWGSPNGAMRRGWNGITISRDTI---HIDGVELGYKKPVLFERHAV 155
Query: 453 ADQYKATDFVVPGAGTLEIIFKPESG-EAIKHVV---HEYKGAGVALAMF-NTDASIIDF 617
+Y A + G G L F P G +A K VV E A+ + N ++ D
Sbjct: 156 GGEYSA-GYKNVGKGKLTTTFTPSEGPDAGKTVVVDEREIVDEEAAVVTYHNPYDNVHDL 214
Query: 618 AHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDREYXKQFEDAGIWYE----- 782
A F L+ K Y+ TK T+ K+ F I + ++D E+ QF AG+ E
Sbjct: 215 ARFFFGRCLEAKVTPYVVTKKTVF-KWQEPFWQIMRTVFDEEFKAQFVAAGVMKEGEELV 273
Query: 783 HRLIDDMVAYAMK-SXGGFVWACKNYDG 863
H L D ++ GGF A NYDG
Sbjct: 274 HLLSDAATMKLVQWRQGGFGMAAHNYDG 301
>UniRef50_A3K670 Cluster: NADP-dependent isocitrate dehydrogenase
protein; n=2; Rhodobacteraceae|Rep: NADP-dependent
isocitrate dehydrogenase protein - Sagittula stellata
E-37
Length = 459
Score = 97.1 bits (231), Expect = 5e-19
Identities = 61/255 (23%), Positives = 125/255 (49%)
Frame = -1
Query: 863 SIIIFAGPDKSTL*FXXXXXXXIN*PVFIPDTSILKLFXVLPVINILKDVFETTIVFLEN 684
++I+ AGPD+ + ++ PV +PD L+L L ++++L+ V E +V LEN
Sbjct: 182 AVIVLAGPDELAVPLERAGHHVVDQPVLVPDALRLELLGKLRLVDLLEQVLEPPVVGLEN 241
Query: 683 CILSA*VQRVFSVQSKLE*RMSKVNNRCISVKHSQCYTCTLVLMNYMFYCLTRFRFEDYF 504
+L V R Q+ ++ KV +R + V H+ +++ L F +
Sbjct: 242 GVLGRQVHRPAQRQTVVQRGAGKVADRLVLVVHAHVDPGIGRVVDLALDHLAVGAFPFHR 301
Query: 503 KSTSTWDNKVSCFVLISMSMTSNDDGFVPPCYKSRYILANNSLPENSTTKNITDGPIRAF 324
+ + ++ VL++ + ++ DG P +++R++ A++ L E+ +++ D +
Sbjct: 302 QLARRGEVEIRGLVLVAEGVPAHHDGRGPARHEARHVAADDRLAEDDAAQDVADRAVGRL 361
Query: 323 PHFLQFKFFNSLLIRSYGRTFDAHIVFLYGLSTINCNLIISLITIFHTQVVDM*FNVQER 144
PH L+ +F ++LL+R R FD L ++ +L+ + + ++V V+ R
Sbjct: 362 PHLLETEFLDTLLVRGDRRAFDRDANLLRLFGGVDGDLVPGPVPLLDPEIVVKQVQVEVR 421
Query: 143 KNQLXFDKIPDYXGH 99
++QL D+ P GH
Sbjct: 422 QDQLFLDESPHDAGH 436
>UniRef50_Q5DBI8 Cluster: SJCHGC09598 protein; n=1; Schistosoma
japonicum|Rep: SJCHGC09598 protein - Schistosoma
japonicum (Blood fluke)
Length = 129
Score = 85.0 bits (201), Expect = 2e-15
Identities = 51/91 (56%), Positives = 55/91 (60%)
Frame = -2
Query: 382 IASLKTVPPRILRMVPLGLFHIXXXXXXXXXXXSGVMVAHLMPTLYFFMASAQSIVT*SS 203
+ S KTVPPRILR+VP G HI SGVMVAHL+PTLYF +ASA SIVT S
Sbjct: 1 MGSRKTVPPRILRIVPFGDSHIFFKLNSLTRCSSGVMVAHLIPTLYFLIASAPSIVTWSL 60
Query: 202 VLSRFSIPKS*TCNSMSKKGRISFXLIRSQI 110
V SR PKS S S G IS IRS I
Sbjct: 61 VRSRLGRPKSKYLQSTSINGNISCCFIRSII 91
>UniRef50_A4VDP7 Cluster: Putative uncharacterized protein; n=1;
Tetrahymena thermophila SB210|Rep: Putative
uncharacterized protein - Tetrahymena thermophila SB210
Length = 141
Score = 56.0 bits (129), Expect = 1e-06
Identities = 38/85 (44%), Positives = 46/85 (54%)
Frame = -2
Query: 352 ILRMVPLGLFHIXXXXXXXXXXXSGVMVAHLMPTLYFFMASAQSIVT*SSVLSRFSIPKS 173
+LR+VPLG HI S V+VAHL+PTL +A A S VT S V SRFSI +S
Sbjct: 1 MLRIVPLGEGHIFLSLNSLTRASSAVIVAHLIPTLCSRIAQAASKVTQSLVASRFSIERS 60
Query: 172 *TCNSMSKKGRISFXLIRSQIXLVI 98
S G +S LI Q+ VI
Sbjct: 61 QYLISAEINGNMSLSLIIFQMIRVI 85
>UniRef50_Q67N12 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Symbiobacterium thermophilum
Length = 357
Score = 51.2 bits (117), Expect = 3e-05
Identities = 42/125 (33%), Positives = 63/125 (50%), Gaps = 2/125 (1%)
Frame = +3
Query: 150 LDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFKLKKMWKS 329
L + L YDL +ENR T ++V + A A++++ G+K ATITP E R + S
Sbjct: 34 LPLHLVRYDLSLENRRATSNRVVYEAAAAMREHGYGLKAATITP-EGRGDV-------GS 85
Query: 330 PNGTIRNILGGTVFREAIICKNIPRLVT--GWDKPIIIGRHAHADQYKATDFVVPGAGTL 503
PN +R + GTV + +P + T G PI + R A D Y+A ++ G G
Sbjct: 86 PNAILRREIDGTVILRT--GRPLPGVETIGGITAPIAVVRMATEDAYEAKEW-REGEGDE 142
Query: 504 EIIFK 518
E F+
Sbjct: 143 ERAFR 147
>UniRef50_Q5E609 Cluster: Putative uncharacterized protein; n=1;
Vibrio fischeri ES114|Rep: Putative uncharacterized
protein - Vibrio fischeri (strain ATCC 700601 / ES114)
Length = 326
Score = 35.1 bits (77), Expect = 2.3
Identities = 16/46 (34%), Positives = 24/46 (52%), Gaps = 2/46 (4%)
Frame = +3
Query: 171 YDLGMENRDKTDDQVTIDCA--EAIKKYNVGIKCATITPDEKRVEE 302
+ G + DK + +DC+ KYN+ +KCAT + DEK E
Sbjct: 86 FSQGFKYEDKVNPPKDVDCSVYHDYAKYNIEVKCATFSDDEKLKSE 131
>UniRef50_A4WT53 Cluster: Sensor protein; n=3; Rhodobacter
sphaeroides|Rep: Sensor protein - Rhodobacter
sphaeroides ATCC 17025
Length = 890
Score = 34.7 bits (76), Expect = 3.1
Identities = 17/49 (34%), Positives = 28/49 (57%)
Frame = +3
Query: 432 IIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEAIKHVVHEYKGAGVA 578
I+G AHAD + +F+ GAG +++ KP + A+ V ++ G G A
Sbjct: 716 IVGATAHADPDRVPEFL--GAGMNDVLVKPITRSALFRAVRQFAGCGQA 762
>UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Thermoproteaceae|Rep: 3-isopropylmalate dehydrogenase -
Pyrobaculum aerophilum
Length = 290
Score = 34.7 bits (76), Expect = 3.1
Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 2/97 (2%)
Frame = +3
Query: 483 VPGAGTLEIIFKPESGEAIKHVVHEYKGAGVALAM-FNTDASIIDFAHSSFKFALDRKYP 659
VP ++ +F E+ E + +V EYK VA+A+ T+ A + K+A R+
Sbjct: 69 VPAVREIDCVFVRENVEDV-YVGAEYKVGDVAIALKVITEKGTRRVARMARKYAEMRRRR 127
Query: 660 LYLSTKNTILKKYDGRFKDI-FQDIYDREYXKQFEDA 767
+ + K +L+ DG F+DI +++ E + + DA
Sbjct: 128 VTIVHKANVLRVVDGFFRDIALEELKGLEVDQMYVDA 164
>UniRef50_UPI0000498AD5 Cluster: hypothetical membrane-spanning
protein; n=1; Entamoeba histolytica HM-1:IMSS|Rep:
hypothetical membrane-spanning protein - Entamoeba
histolytica HM-1:IMSS
Length = 453
Score = 33.1 bits (72), Expect = 9.3
Identities = 30/127 (23%), Positives = 57/127 (44%), Gaps = 3/127 (2%)
Frame = -1
Query: 560 VLMNYMFYCLTRFRFEDYFKSTSTWDNKVSCF--VLISMSMTSNDDGFVP-PCYKSRYIL 390
+L N +F + Y KS+S V+ ++ ++ + F+ P Y R +L
Sbjct: 24 LLKNDIFGYEKEIHYPIYKKSSSPIQQSVNLTQQIVNENTIPQSVKSFIQTPFYLERSVL 83
Query: 389 ANNSLPENSTTKNITDGPIRAFPHFLQFKFFNSLLIRSYGRTFDAHIVFLYGLSTINCNL 210
+ ++ + + P+R +F Q F N ++ Y R +D + +Y LST+ C +
Sbjct: 84 IGLLISWDTFSSFLLFTPLRIISYFYQLIFLNEKVVIHYKRIYD---ILMY-LSTLFCVI 139
Query: 209 IISLITI 189
II + I
Sbjct: 140 IIYQVDI 146
>UniRef50_A0C1D3 Cluster: Chromosome undetermined scaffold_141,
whole genome shotgun sequence; n=1; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_141,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 490
Score = 33.1 bits (72), Expect = 9.3
Identities = 23/91 (25%), Positives = 40/91 (43%), Gaps = 3/91 (3%)
Frame = +3
Query: 495 GTLEIIFKPESGEAIKHVVHEYKGAGV---ALAMFNTDASIIDFAHSSFKFALDRKYPLY 665
G +E KP +K VH +L++ ++ I + H SFK L +
Sbjct: 71 GFIEEDGKPPETTCLKLAVHRLDNTPQIIQSLSIITSNNIINQWRHYSFKLPLPKLNNQD 130
Query: 666 LSTKNTILKKYDGRFKDIFQDIYDREYXKQF 758
+STKN ++ Y+G + F+ R++ F
Sbjct: 131 VSTKNQKIRAYNGSYSINFESTQQRDFKYVF 161
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 824,615,885
Number of Sequences: 1657284
Number of extensions: 16773686
Number of successful extensions: 42378
Number of sequences better than 10.0: 22
Number of HSP's better than 10.0 without gapping: 40541
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 42350
length of database: 575,637,011
effective HSP length: 100
effective length of database: 409,908,611
effective search space used: 76652910257
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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