Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fcaL-P05_F_N02
(786 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p... 306 3e-82
UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8; Bilateri... 304 1e-81
UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 222 7e-57
UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella ve... 200 3e-50
UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 189 8e-47
UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 180 5e-44
UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;... 179 8e-44
UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulato... 175 1e-42
UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulato... 175 1e-42
UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 170 4e-41
UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma... 151 1e-35
UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]... 148 1e-34
UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 141 2e-32
UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalyti... 140 3e-32
UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3; Bacteria... 132 7e-30
UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 131 2e-29
UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep: C... 116 5e-25
UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate... 111 2e-23
UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421, ... 104 2e-21
UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependen... 101 2e-20
UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate dehydrog... 101 3e-20
UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 100 5e-20
UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2; Bacteria... 99 6e-20
UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3; Ricketts... 99 6e-20
UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68; Bacteri... 99 6e-20
UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6; T... 96 8e-19
UniRef50_Q4UKR1 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 94 3e-18
UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD] s... 91 3e-17
UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]... 89 9e-17
UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8; E... 86 8e-16
UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10; ... 83 1e-14
UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6; E... 82 2e-14
UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1... 81 3e-14
UniRef50_Q2Q9C5 Cluster: Isocitrate dehydrogenase 3 gamma; n=8; ... 81 3e-14
UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate dehydrog... 80 7e-14
UniRef50_Q2UP37 Cluster: Isocitrate/isopropylmalate dehydrogenas... 77 4e-13
UniRef50_Q4V533 Cluster: IP13250p; n=4; Drosophila melanogaster|... 76 9e-13
UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3; P... 75 3e-12
UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9; Eut... 73 6e-12
UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 70 8e-11
UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1; Ent... 69 1e-10
UniRef50_Q58991 Cluster: Threo-isocitrate dehydrogenase [NAD]; n... 69 2e-10
UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;... 67 4e-10
UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2; Alp... 66 1e-09
UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenas... 65 2e-09
UniRef50_Q0W1Q6 Cluster: 2-isopropylmalate dehydrogenase; n=5; E... 65 2e-09
UniRef50_Q5HNL1 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 64 5e-09
UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9; B... 61 4e-08
UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5; C... 59 1e-07
UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5; T... 59 1e-07
UniRef50_Q9RTT2 Cluster: Isocitrate dehydrogenase, putative; n=2... 58 2e-07
UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase, mitochond... 58 2e-07
UniRef50_Q8XSY8 Cluster: Probable 3-isopropylmalate dehydrogenas... 58 3e-07
UniRef50_Q2VF40 Cluster: Isocitrate dehydrogenase 3 gamma subuni... 57 4e-07
UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 57 4e-07
UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 55 2e-06
UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependen... 55 2e-06
UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;... 52 1e-05
UniRef50_A1SM34 Cluster: 3-isopropylmalate dehydrogenase; n=1; N... 52 2e-05
UniRef50_O29610 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 52 2e-05
UniRef50_A5DIP7 Cluster: Putative uncharacterized protein; n=1; ... 51 3e-05
UniRef50_P41566 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 47 4e-05
UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 51 4e-05
UniRef50_Q9CKK6 Cluster: Idp; n=2; Pasteurellaceae|Rep: Idp - Pa... 50 7e-05
UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for ... 50 7e-05
UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase; n... 49 2e-04
UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;... 48 2e-04
UniRef50_A5URE6 Cluster: Isocitrate dehydrogenase, NADP-dependen... 47 6e-04
UniRef50_Q0X0C1 Cluster: Putative dehydrogenase; n=1; Streptomyc... 46 8e-04
UniRef50_A7T3D9 Cluster: Predicted protein; n=1; Nematostella ve... 46 8e-04
UniRef50_A5DIP6 Cluster: Putative uncharacterized protein; n=1; ... 46 0.001
UniRef50_Q8U299 Cluster: 3-isopropylmalate dehydrogenase 2; n=3;... 43 0.008
UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: Leu... 42 0.023
UniRef50_Q6L2P9 Cluster: Isocitrate dehydrogenase [NADP]; n=2; T... 41 0.031
UniRef50_Q8FPV5 Cluster: 3-isopropylmalate dehydrogenase; n=50; ... 41 0.031
UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2; Bacillacea... 40 0.071
UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular ... 40 0.093
UniRef50_A6G3V7 Cluster: Probable 3-isopropylmalate dehydrogenas... 39 0.16
UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1; S... 38 0.38
UniRef50_P56471 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 36 0.87
UniRef50_Q89RJ1 Cluster: 3-isopropylmalate dehydrogenase; n=7; A... 36 1.2
UniRef50_A7GLU7 Cluster: Tartrate dehydrogenase; n=3; Bacteria|R... 36 1.5
UniRef50_Q08KN2 Cluster: FIg-Hepta; n=3; Takifugu rubripes|Rep: ... 35 2.0
UniRef50_A6PN62 Cluster: 3-isopropylmalate dehydrogenase; n=1; V... 35 2.0
UniRef50_A4C445 Cluster: VCBS; n=1; Pseudoalteromonas tunicata D... 35 2.0
UniRef50_A5UWW1 Cluster: Agmatine deiminase; n=9; cellular organ... 35 2.7
UniRef50_A0E5I0 Cluster: Chromosome undetermined scaffold_8, who... 35 2.7
UniRef50_A3Y262 Cluster: Phosphorelay protein; n=4; Vibrionales|... 34 3.5
UniRef50_P35484 Cluster: Dihydrolipoyl dehydrogenase; n=3; Achol... 34 3.5
UniRef50_Q13FQ0 Cluster: Tartrate dehydrogenase; n=3; Proteobact... 33 6.1
UniRef50_A3W960 Cluster: SCO1/SenC family protein; n=2; Roseovar... 33 6.1
UniRef50_Q8IC48 Cluster: Putative uncharacterized protein PF07_0... 33 6.1
UniRef50_A0DX95 Cluster: Chromosome undetermined scaffold_68, wh... 33 6.1
>UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p -
Drosophila melanogaster (Fruit fly)
Length = 402
Score = 306 bits (752), Expect = 3e-82
Identities = 143/213 (67%), Positives = 171/213 (80%), Gaps = 3/213 (1%)
Frame = +2
Query: 155 DVQHKTPVIRKQKL---IPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEV 325
DV H ++K+ IP AQYGGRHAVTMLPGGGIGPE MGYVR+IF+Y GAPIDFEV
Sbjct: 32 DVAHTKSALQKKVTGTDIPSAQYGGRHAVTMLPGGGIGPELMGYVREIFRYCGAPIDFEV 91
Query: 326 VDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNC 505
+DIDP+ + +DD+ YAIT+IKRNGV LKGNIETKS++ SRNVA+RNELD+Y +++C
Sbjct: 92 IDIDPSTEGNDDLDYAITSIKRNGVALKGNIETKSQSLTEVSRNVAIRNELDLYVNVVHC 151
Query: 506 KSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVXXXXXXXX 685
KSYPG+ RH DIDVV+IRQNT+GEYAMLEHESV G+VESMKVVT +N+ERV
Sbjct: 152 KSYPGIPARHHDIDVVLIRQNTDGEYAMLEHESVPGIVESMKVVTVENAERVARYAFEFA 211
Query: 686 XKNGRXKVTTVHKANIMKLSDGLFLETSXRLAK 784
+N R KVTT+HKANIMKLSDGLFLE + R+ K
Sbjct: 212 RQNNRKKVTTIHKANIMKLSDGLFLEVANRVHK 244
>UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8;
Bilateria|Rep: Isocitrate dehydrogenase - Aedes aegypti
(Yellowfever mosquito)
Length = 393
Score = 304 bits (747), Expect = 1e-81
Identities = 139/213 (65%), Positives = 169/213 (79%)
Frame = +2
Query: 146 SDFDVQHKTPVIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEV 325
S F++QHK P+ RK + IPKA YGGRH VTMLPGGGIGPE M YV+++F++ G P+DFEV
Sbjct: 24 SAFELQHKNPLQRKVEKIPKAHYGGRHTVTMLPGGGIGPELMNYVKEVFRFAGVPVDFEV 83
Query: 326 VDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNC 505
VDIDP + +DD++YAIT+IKRNGV LKGNIETKSEA + SRNVALRNELD+Y +L+C
Sbjct: 84 VDIDPASEGNDDLEYAITSIKRNGVALKGNIETKSEATGIISRNVALRNELDLYVNVLHC 143
Query: 506 KSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVXXXXXXXX 685
KS+ + H+++DVVIIRQNTEGEYAMLEHESV GVVESMKVVT +N+ RV
Sbjct: 144 KSFNAIPAHHQNVDVVIIRQNTEGEYAMLEHESVRGVVESMKVVTVENAARVARYAFEFA 203
Query: 686 XKNGRXKVTTVHKANIMKLSDGLFLETSXRLAK 784
N R KVTT+HKANIMKL+DGLFL + +AK
Sbjct: 204 RANNRKKVTTIHKANIMKLADGLFLSVAREVAK 236
>UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=50;
Deuterostomia|Rep: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 393
Score = 222 bits (543), Expect = 7e-57
Identities = 108/210 (51%), Positives = 143/210 (68%), Gaps = 4/210 (1%)
Frame = +2
Query: 164 HKTP---VIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDI 334
H+ P + +Q + P A+YGGRH VTM+PG GIGPE M +V+ +F++ P+DFE V +
Sbjct: 32 HEVPSRNIFSEQTIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHV 91
Query: 335 DPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYV-TSRNVALRNELDMYAYILNCKS 511
D ++D++ AI I+RN V LKGNIET SRN LR LD+YA +++CKS
Sbjct: 92 SSNAD-EEDIRNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKS 150
Query: 512 YPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVXXXXXXXXXK 691
PGV TRHKDID++I+R+NTEGEY+ LEHESV GVVES+K++T S R+ +
Sbjct: 151 LPGVVTRHKDIDILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQE 210
Query: 692 NGRXKVTTVHKANIMKLSDGLFLETSXRLA 781
+GR KVT VHKANIMKL DGLFL+ +A
Sbjct: 211 SGRKKVTAVHKANIMKLGDGLFLQCCREVA 240
>UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 394
Score = 200 bits (488), Expect = 3e-50
Identities = 99/193 (51%), Positives = 134/193 (69%), Gaps = 6/193 (3%)
Frame = +2
Query: 200 PKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDD-----V 364
P A+YGGR+ VT++PG GIGPE + V+DIF++IG P+DFE +++ D+D
Sbjct: 43 PPARYGGRNTVTLIPGDGIGPEMVVAVQDIFRHIGVPVDFEELNLSGLDIKDEDSYLGAF 102
Query: 365 QYAITTIKRNGVGLKGNIETKSEAAY-VTSRNVALRNELDMYAYILNCKSYPGVATRHKD 541
AIT+IKRNGV +KGNI T +A S N+ LR LD++A I+ CKS PG+ TRH +
Sbjct: 103 NEAITSIKRNGVAMKGNIFTPLDAIPGFRSLNLELRVHLDLFANIVRCKSIPGIQTRHNN 162
Query: 542 IDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVH 721
+D+VIIRQNTEGEY+ LEHE+V+GV+E++KV T + ++ K+ R KVT VH
Sbjct: 163 VDLVIIRQNTEGEYSHLEHENVSGVIENLKVTTEEACMKIAQYAFDFAEKHDRKKVTAVH 222
Query: 722 KANIMKLSDGLFL 760
KANIMK+ DGLFL
Sbjct: 223 KANIMKMGDGLFL 235
>UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1;
Kluyveromyces lactis|Rep: Isocitrate dehydrogenase [NAD]
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Kluyveromyces lactis (Yeast) (Candida sphaerica)
Length = 361
Score = 189 bits (460), Expect = 8e-47
Identities = 98/193 (50%), Positives = 130/193 (67%)
Frame = +2
Query: 188 QKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQ 367
++L+PK +YGGR+ VT++PG G+G E V IF+ PID+E +DI ++N ++VQ
Sbjct: 19 EQLLPK-KYGGRYTVTLIPGDGVGKEVTDSVVKIFENENIPIDWETIDISG-LENTENVQ 76
Query: 368 YAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDID 547
A+ ++KRN VGLKG T ++ S NVALR +LD++A + KS PGV TR +ID
Sbjct: 77 RAVESLKRNKVGLKGIWHTPADQTGHGSLNVALRKQLDIFANVALFKSIPGVKTRLNNID 136
Query: 548 VVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKA 727
+VIIR+NTEGEY+ LEHESV GVVES+K++T SER+ KN R V VHKA
Sbjct: 137 MVIIRENTEGEYSGLEHESVPGVVESLKIMTRAKSERIARFAFDFALKNNRKSVCAVHKA 196
Query: 728 NIMKLSDGLFLET 766
NIMKL DGLF T
Sbjct: 197 NIMKLGDGLFRNT 209
>UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=32;
Dikarya|Rep: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 360
Score = 180 bits (437), Expect = 5e-44
Identities = 93/190 (48%), Positives = 125/190 (65%)
Frame = +2
Query: 188 QKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQ 367
++ +PK +YGGR VT++PG G+G E VR IF+ PID+E ++I T D+ + V
Sbjct: 18 ERTLPK-KYGGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQT-DHKEGVY 75
Query: 368 YAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDID 547
A+ ++KRN +GLKG T ++ S NVALR +LD+YA + KS GV TR DID
Sbjct: 76 EAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDID 135
Query: 548 VVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKA 727
+++IR+NTEGE++ LEHESV GVVES+KV+T +ER+ K R VT VHKA
Sbjct: 136 LIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKA 195
Query: 728 NIMKLSDGLF 757
NIMKL DGLF
Sbjct: 196 NIMKLGDGLF 205
>UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;
Glossina morsitans morsitans|Rep: Isocitrate
dehydrogenase (NAD+) 2 - Glossina morsitans morsitans
(Savannah tsetse fly)
Length = 372
Score = 179 bits (435), Expect = 8e-44
Identities = 89/200 (44%), Positives = 132/200 (66%), Gaps = 5/200 (2%)
Frame = +2
Query: 200 PKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFE---VVDIDPTMDNDDDVQY 370
P A G R T++PG G+GPE + ++++FK P+DFE + +++P + ++
Sbjct: 32 PGALGGNRTTCTLIPGDGVGPELVQCLQEVFKSADVPVDFECYFLSEVNPVLSAK--LED 89
Query: 371 AITTIKRNGVGLKGNIETK--SEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDI 544
I +I++N V +KG + T S + S N+ LRNELD+YA +++ +S PGV TR++DI
Sbjct: 90 VIASIRKNKVCIKGVLATPDYSNVGELQSLNMKLRNELDLYANVVHARSLPGVKTRYQDI 149
Query: 545 DVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHK 724
D+V+IR+ TEGEY+ LEHESV G+VE +K++TA S R+ KN R KVT+VHK
Sbjct: 150 DIVVIREQTEGEYSALEHESVPGIVECLKIITAKKSMRIAKFAFDYAIKNSRKKVTSVHK 209
Query: 725 ANIMKLSDGLFLETSXRLAK 784
ANIMKL DGLFL++ +AK
Sbjct: 210 ANIMKLGDGLFLKSCEDMAK 229
>UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 1) (NAD(+)-specific ICDH 1);
n=7; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 1, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 1) (NAD(+)-specific
ICDH 1) - Arabidopsis thaliana (Mouse-ear cress)
Length = 367
Score = 175 bits (426), Expect = 1e-42
Identities = 93/201 (46%), Positives = 126/201 (62%)
Frame = +2
Query: 182 RKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDD 361
R +P+ G AVT++PG GIGP V + + + API FE D+ M
Sbjct: 24 RSVTYMPRPGDGAPRAVTLIPGDGIGPLVTNAVEQVMEAMHAPIFFEKYDVHGEMSRVPP 83
Query: 362 VQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKD 541
+ +I++N V LKG ++T V+S NV LR ELD++A ++NC + PG+ TRH++
Sbjct: 84 E--VMESIRKNKVCLKGGLKTPVGGG-VSSLNVQLRKELDLFASLVNCFNLPGLPTRHEN 140
Query: 542 IDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVH 721
+D+V+IR+NTEGEYA LEHE V GVVES+KV+T SER+ N R KVT VH
Sbjct: 141 VDIVVIRENTEGEYAGLEHEVVPGVVESLKVITKFCSERIAKYAFEYAYLNNRKKVTAVH 200
Query: 722 KANIMKLSDGLFLETSXRLAK 784
KANIMKL+DGLFLE+ +AK
Sbjct: 201 KANIMKLADGLFLESCREVAK 221
>UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 3, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 3) (NAD(+)-specific ICDH 3);
n=23; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 3, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 3) (NAD(+)-specific
ICDH 3) - Arabidopsis thaliana (Mouse-ear cress)
Length = 368
Score = 175 bits (425), Expect = 1e-42
Identities = 92/205 (44%), Positives = 128/205 (62%)
Frame = +2
Query: 170 TPVIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMD 349
T + R +P+ G VT++PG GIGP G V + + + AP+ FE ++ M
Sbjct: 21 TSLSRSITYMPRPGDGAPRTVTLIPGDGIGPLVTGAVEQVMEAMHAPVHFERYEVLGNMR 80
Query: 350 NDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT 529
+ I ++KRN V LKG + T V+S N+ LR ELD++A ++NC + PG+ T
Sbjct: 81 KVPEE--VIESVKRNKVCLKGGLATPVGGG-VSSLNMQLRKELDIFASLVNCINVPGLVT 137
Query: 530 RHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKV 709
RH+++D+V+IR+NTEGEY+ LEHE V GVVES+KV+T SER+ N R KV
Sbjct: 138 RHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIARYAFEYAYLNNRKKV 197
Query: 710 TTVHKANIMKLSDGLFLETSXRLAK 784
T VHKANIMKL+DGLFLE+ +AK
Sbjct: 198 TAVHKANIMKLADGLFLESCREVAK 222
>UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit
beta, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=61;
Fungi/Metazoa group|Rep: Isocitrate dehydrogenase [NAD]
subunit beta, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 385
Score = 170 bits (413), Expect = 4e-41
Identities = 82/192 (42%), Positives = 122/192 (63%), Gaps = 3/192 (1%)
Frame = +2
Query: 218 GRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPT--MDNDDDVQYAITTIKR 391
G VTMLPG G+GPE M V+++FK P++F+ + M +++ ++ ++++K
Sbjct: 47 GSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKE 106
Query: 392 NGVGLKGNIETKSE-AAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQN 568
N V + G I T E + S ++ LR +LD++A +++ KS PG TRH ++D+VIIR+
Sbjct: 107 NKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQ 166
Query: 569 TEGEYAMLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKANIMKLSD 748
TEGEY+ LEHES GV+E +K+VT S+R+ K GR KVT VHKANIMKL D
Sbjct: 167 TEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGD 226
Query: 749 GLFLETSXRLAK 784
GLFL+ +A+
Sbjct: 227 GLFLQCCEEVAE 238
>UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma;
n=1; Danio rerio|Rep: Isocitrate dehydrogenase 3 (NAD+)
gamma - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 289
Score = 151 bits (367), Expect = 1e-35
Identities = 70/163 (42%), Positives = 107/163 (65%), Gaps = 1/163 (0%)
Frame = +2
Query: 161 QHKTPVIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDP 340
Q P + + P A+YGGRH VT++PG GIGPE + +VR++F++ P+DFEVV ++
Sbjct: 30 QRGKPTYSGRIIPPPAKYGGRHTVTLIPGDGIGPELLNHVRELFRFSCVPVDFEVVHVNS 89
Query: 341 TMDNDDDVQYAITTIKRNGVGLKGNIETK-SEAAYVTSRNVALRNELDMYAYILNCKSYP 517
+ ++DD+ AI I+RNGV LKGNIET + SRN LR LD+YA +++C+S P
Sbjct: 90 SSTSEDDISNAIMAIRRNGVALKGNIETNHTMPPNHKSRNNLLRTSLDLYANVMHCQSLP 149
Query: 518 GVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTAD 646
GV TRHK+ID++II + +E + E+E + + +++ AD
Sbjct: 150 GVQTRHKNIDIIIILEKSEFSALLAENEKIKVELLQLRIQLAD 192
>UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH); n=6;
Eukaryota|Rep: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Caenorhabditis elegans
Length = 358
Score = 148 bits (359), Expect = 1e-34
Identities = 81/185 (43%), Positives = 109/185 (58%), Gaps = 3/185 (1%)
Frame = +2
Query: 215 GGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQY---AITTI 385
G VT++PG GIGPE V+ IF+ API ++ VD+ P D + I +
Sbjct: 22 GDVRRVTLIPGDGIGPEISASVQKIFEAADAPIAWDPVDVTPVKGRDGVFRIPSRCIELM 81
Query: 386 KRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQ 565
N VGLKG +ET + S N+A+R E +YA + C+S G T + ++DVV IR+
Sbjct: 82 HANKVGLKGPLETPIGKGH-RSLNLAVRKEFSLYANVRPCRSLEGHKTLYDNVDVVTIRE 140
Query: 566 NTEGEYAMLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKANIMKLS 745
NTEGEY+ +EHE V GVV+S+K++T S V +NGR VT VHKANIM+ S
Sbjct: 141 NTEGEYSGIEHEIVPGVVQSIKLITETASRNVASFAFEYARQNGRKVVTAVHKANIMRQS 200
Query: 746 DGLFL 760
DGLFL
Sbjct: 201 DGLFL 205
>UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=62;
Eukaryota|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Homo sapiens
(Human)
Length = 366
Score = 141 bits (342), Expect = 2e-32
Identities = 82/222 (36%), Positives = 119/222 (53%), Gaps = 3/222 (1%)
Frame = +2
Query: 128 AAPATLSDFDVQHKTPVIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGA 307
A PA +S V K + + GG VT++PG GIGPE V IF A
Sbjct: 2 AGPAWISK--VSRLLGAFHNPKQVTRGFTGGVQTVTLIPGDGIGPEISAAVMKIFDAAKA 59
Query: 308 PIDFEVVDIDPTMDNDDDVQY---AITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNEL 478
PI +E ++ A ++ +N +GLKG ++T A + S N+ LR
Sbjct: 60 PIQWEERNVTAIQGPGGKWMIPSEAKESMDKNKMGLKGPLKTPIAAGH-PSMNLLLRKTF 118
Query: 479 DMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSER 658
D+YA + C S G T + D+++V IR+NTEGEY+ +EH V+GVV+S+K++T S+R
Sbjct: 119 DLYANVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEGASKR 178
Query: 659 VXXXXXXXXXKNGRXKVTTVHKANIMKLSDGLFLETSXRLAK 784
+ N R VT VHKANIM++SDGLFL+ +A+
Sbjct: 179 IAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAE 220
>UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalytic
subunit 6, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 6) (NAD(+)-specific ICDH 6);
n=10; cellular organisms|Rep: Isocitrate dehydrogenase
[NAD] catalytic subunit 6, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 6) (NAD(+)-specific
ICDH 6) - Arabidopsis thaliana (Mouse-ear cress)
Length = 374
Score = 140 bits (340), Expect = 3e-32
Identities = 76/187 (40%), Positives = 110/187 (58%), Gaps = 4/187 (2%)
Frame = +2
Query: 233 TMLPGGGIGPECMGYVRDIFKYIGAPIDFEV----VDIDPTMDNDDDVQYAITTIKRNGV 400
T+ PG GIGPE V+ +F ID++ ++DP N + ++ +N V
Sbjct: 47 TLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFVGTEVDPRT-NSFLTWDNLQSVLKNKV 105
Query: 401 GLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGE 580
GLKG + T + S N+ LR EL++YA + C S PG TR+ D+D++ IR+NTEGE
Sbjct: 106 GLKGPMATPIGKGH-RSLNLTLRKELNLYANVRPCYSLPGYKTRYDDVDLITIRENTEGE 164
Query: 581 YAMLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKANIMKLSDGLFL 760
Y+ LEH+ V GVVES+K++T S RV +GR KV+ +HKANIM+ +DGLFL
Sbjct: 165 YSGLEHQVVKGVVESLKIITRKASMRVAEYAFLYAKTHGRKKVSAIHKANIMQKTDGLFL 224
Query: 761 ETSXRLA 781
+ +A
Sbjct: 225 QCCDEVA 231
>UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3;
Bacteria|Rep: Isocitrate dehydrogenase - Acidobacteria
bacterium (strain Ellin345)
Length = 348
Score = 132 bits (320), Expect = 7e-30
Identities = 68/190 (35%), Positives = 110/190 (57%), Gaps = 3/190 (1%)
Frame = +2
Query: 224 HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFE--VVDIDPTMDNDDDVQYAIT-TIKRN 394
+ +T++PG GIGPE + + G ++E + + + + +I+R
Sbjct: 3 YKITLIPGDGIGPEVTSAAVRVLEATGLKFEWESFAAGAEAYEKYKEYIPKELNESIERT 62
Query: 395 GVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTE 574
+GLKG + T + +S NV LR ++YA + ++ PGV TR+ +D+V++R+NTE
Sbjct: 63 RIGLKGPVTTPIGGGF-SSINVELRKRFELYANVRPIRNLPGVHTRYPGVDLVVVRENTE 121
Query: 575 GEYAMLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKANIMKLSDGL 754
G Y+ +EHE V GVVES+K++T S R+ K GR K+ ++HKANIMK+SDGL
Sbjct: 122 GLYSGIEHEVVPGVVESLKIITEKASTRISKFAFNYARKMGRKKIHSIHKANIMKMSDGL 181
Query: 755 FLETSXRLAK 784
F+ S ++K
Sbjct: 182 FIRCSRNISK 191
>UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=31; cellular
organisms|Rep: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 369
Score = 131 bits (316), Expect = 2e-29
Identities = 71/191 (37%), Positives = 108/191 (56%), Gaps = 2/191 (1%)
Frame = +2
Query: 218 GRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDV--QYAITTIKR 391
G++ V+ + G GIGPE V+ IF PI++E D+ P N A+ +I +
Sbjct: 35 GKYTVSFIEGDGIGPEISKSVKKIFSAANVPIEWESCDVSPIFVNGLTTIPDPAVQSITK 94
Query: 392 NGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNT 571
N V LKG + T + S N+ LR ++A + KS G T ++++D+V+IR+NT
Sbjct: 95 NLVALKGPLATPIGKGH-RSLNLTLRKTFGLFANVRPAKSIEGFKTTYENVDLVLIRENT 153
Query: 572 EGEYAMLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKANIMKLSDG 751
EGEY+ +EH GVV+S+K++T D SERV GR +V VHK+ I +L+DG
Sbjct: 154 EGEYSGIEHIVCPGVVQSIKLITRDASERVIRYAFEYARAIGRPRVIVVHKSTIQRLADG 213
Query: 752 LFLETSXRLAK 784
LF+ + L+K
Sbjct: 214 LFVNVAKELSK 224
>UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep:
CG3483 protein - Drosophila melanogaster (Fruit fly)
Length = 391
Score = 116 bits (280), Expect = 5e-25
Identities = 60/178 (33%), Positives = 101/178 (56%)
Frame = +2
Query: 230 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLK 409
VT++ G G+G E M V+++ + API+++V D D+DD + +++ N VG+K
Sbjct: 72 VTLINGEGVGRELMDAVQEVICAVKAPIEWDVHDEFKAKDSDDVSPEVLKSLRANKVGIK 131
Query: 410 GNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAM 589
G ++++ + R + +AY+ C G+ + + D DVVIIR EG+Y+
Sbjct: 132 GPVDSRHWQRQI-------RKQFAQFAYVSLCSHIEGLDSPYGDFDVVIIRDQMEGDYSG 184
Query: 590 LEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKANIMKLSDGLFLE 763
+EH V GV++++KV T + R+ KN R ++T HKANIM+++DG FLE
Sbjct: 185 IEHLVVPGVMQTIKVSTTAGAARIAEFVFNYAVKNKRKRITVAHKANIMRMTDGNFLE 242
>UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8; n=1; Pan
troglodytes|Rep: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8 - Pan troglodytes
Length = 331
Score = 111 bits (267), Expect = 2e-23
Identities = 54/138 (39%), Positives = 86/138 (62%), Gaps = 3/138 (2%)
Frame = +2
Query: 218 GRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPT--MDNDDDVQYAITTIKR 391
G VTMLPG G+GPE M V+++FK P++F+ + M +++ ++ ++++K
Sbjct: 47 GSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKE 106
Query: 392 NGVGLKGNIETKSE-AAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQN 568
N V + G I T E + S ++ LR +LD++A +++ KS PG TRH ++D+VIIR+
Sbjct: 107 NKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQ 166
Query: 569 TEGEYAMLEHESVNGVVE 622
TEGEY+ LEHE V E
Sbjct: 167 TEGEYSSLEHECCEEVAE 184
>UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421,
highly similar to PROTEIN KINASE C-BINDING PROTEIN
NELL1; n=2; Homo sapiens|Rep: CDNA FLJ36019 fis, clone
TESTI2016421, highly similar to PROTEIN KINASE C-BINDING
PROTEIN NELL1 - Homo sapiens (Human)
Length = 355
Score = 104 bits (250), Expect = 2e-21
Identities = 48/100 (48%), Positives = 65/100 (65%)
Frame = +2
Query: 464 LRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTA 643
L LD+YA +++ K+ P V T HKD+D++++ +NTEGEY+ LEHESV GV ES+K++T
Sbjct: 2 LHTTLDLYASVIHLKNLPNVETWHKDVDILVVWENTEGEYSNLEHESVKGVTESLKIMTK 61
Query: 644 DNSERVXXXXXXXXXKNGRXKVTTVHKANIMKLSDGLFLE 763
S R+ K G KV VHK NI KL DG FL+
Sbjct: 62 AKSLRIAEYAFQLAQKMGCKKVMAVHKVNITKLGDGPFLQ 101
>UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=6; Rickettsiales|Rep: Isocitrate dehydrogenase,
NADP-dependent - Orientia tsutsugamushi (strain Boryong)
(Rickettsia tsutsugamushi)
Length = 519
Score = 101 bits (242), Expect = 2e-20
Identities = 67/190 (35%), Positives = 94/190 (49%), Gaps = 6/190 (3%)
Frame = +2
Query: 230 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITT-----IKRN 394
VT+ G GIGPE M V + K P+ E ++I + N Y IT I R
Sbjct: 7 VTIAYGDGIGPEIMEAVVYVLKEAAVPLRLETIEIGEKLYNKY-YTYGITEDTWSQIFRT 65
Query: 395 GVGLKGNIETKSEAAYVTSRNVALRNELDMYAYIL-NCKSYPGVATRHKDIDVVIIRQNT 571
LKG + T Y S NV LR L +YA + +C +P V T +IDVVIIR+N
Sbjct: 66 KALLKGPVTTPQGGGY-KSLNVTLRKTLGLYANVRPSCSYFPFVNTSAPEIDVVIIRENE 124
Query: 572 EGEYAMLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKANIMKLSDG 751
E YA +E+ ES+K+++ SE++ KN R ++ K NIMK +DG
Sbjct: 125 EDLYAGIEYHHTADTYESVKLISRSGSEKIIRFAFEYALKNNRKTISCFSKDNIMKFTDG 184
Query: 752 LFLETSXRLA 781
+F +T +A
Sbjct: 185 IFHKTFNEIA 194
>UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase family protein; n=9; Bacteria|Rep:
Isopropylmalate/isohomocitrate dehydrogenase family
protein - Synechococcus sp. (strain JA-3-3Ab)
(Cyanobacteria bacteriumYellowstone A-Prime)
Length = 368
Score = 101 bits (241), Expect = 3e-20
Identities = 68/212 (32%), Positives = 107/212 (50%), Gaps = 25/212 (11%)
Frame = +2
Query: 224 HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDV-----QYAITTIK 388
+ VT++PG GIGPE + + + G +D E + ++ ++ + + +I+
Sbjct: 3 YRVTLIPGDGIGPEVTRAMTTVLEASG--VDLEWIRVEAGVEVIEKYGTPLPPQVLESIR 60
Query: 389 RNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQN 568
V +KG I T + S NVA+R ELD+YA + KS PG+ + +DID+V++R+N
Sbjct: 61 ETRVAIKGPIGTPVGTGF-RSVNVAIRKELDLYANLRPAKSLPGIKSPFQDIDLVVVREN 119
Query: 569 TEGEYAMLEHES--------------------VNGVVESMKVVTADNSERVXXXXXXXXX 688
TE YA +E E G +K ++ S R+
Sbjct: 120 TEDLYAGIEFERGTPEAAHAREEMMRLSGKFIREGSAIGIKPISEFGSRRIVKFAFEYAR 179
Query: 689 KNGRXKVTTVHKANIMKLSDGLFLETSXRLAK 784
+NGR KVT VHKANIMK +DGLFL+ + +A+
Sbjct: 180 QNGRKKVTAVHKANIMKFTDGLFLQVAREVAQ 211
>UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=5; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) - Thermus
thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Length = 496
Score = 100 bits (239), Expect = 5e-20
Identities = 60/195 (30%), Positives = 100/195 (51%), Gaps = 6/195 (3%)
Frame = +2
Query: 218 GRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDV----QYAITTI 385
GR +T++PG GIGPEC+ + + AP+ +EV + ++ Q I +I
Sbjct: 18 GRKLITVIPGDGIGPECVEATLKVLEAAKAPLAYEVREAGASVFRRGIASGVPQETIESI 77
Query: 386 KRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRH--KDIDVVII 559
++ V LKG +ET S NV LR + YA + + +P V T + + ID+V++
Sbjct: 78 RKTRVVLKGPLETPVGYGE-KSANVTLRKLFETYANVRPVREFPNVPTPYAGRGIDLVVV 136
Query: 560 RQNTEGEYAMLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKANIMK 739
R+N E YA +EH V +++K+++ SE++ GR KV K+NIMK
Sbjct: 137 RENVEDLYAGIEHMQTPSVAQTLKLISWKGSEKIVRFAFELARAEGRKKVHCATKSNIMK 196
Query: 740 LSDGLFLETSXRLAK 784
L++G ++A+
Sbjct: 197 LAEGTLKRAFEQVAQ 211
>UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2;
Bacteria|Rep: Isocitrate dehydrogenase - Gloeobacter
violaceus
Length = 359
Score = 99 bits (238), Expect = 6e-20
Identities = 66/209 (31%), Positives = 109/209 (52%), Gaps = 23/209 (11%)
Frame = +2
Query: 224 HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQY---AITTIKRN 394
+ VT++ G GIGPE R + G ++ VVD + I ++ +
Sbjct: 4 YRVTLIRGDGIGPEVTQAARIVLDATGIDFEWVVVDAGAEVMEKSGTPLPAPVIEAVRAS 63
Query: 395 GVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTE 574
+KG I T + + + S NVALR LD+YA + ++ PGV +R+ +ID+V++R+NTE
Sbjct: 64 DAAIKGPITTPAGSG-IRSVNVALRRALDLYANLRPARTLPGVHSRYDNIDLVVVRENTE 122
Query: 575 GEYAMLEHESVN----GVVE----------------SMKVVTADNSERVXXXXXXXXXKN 694
Y+ +E E + V+E ++K ++++ SER+ ++
Sbjct: 123 DLYSGIEFEKNSPQALEVIEMLMRLGGKKIFPRSGLAVKPISSEASERIARFAFEYARRH 182
Query: 695 GRXKVTTVHKANIMKLSDGLFLETSXRLA 781
R KVT VHKANI+K +DGLFLE + ++A
Sbjct: 183 ARRKVTAVHKANILKHTDGLFLEAARQVA 211
>UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3;
Rickettsiales|Rep: Isocitrate dehydrogenase - Anaplasma
marginale (strain St. Maries)
Length = 488
Score = 99 bits (238), Expect = 6e-20
Identities = 66/190 (34%), Positives = 94/190 (49%), Gaps = 5/190 (2%)
Frame = +2
Query: 230 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQ----YAITTIKRNG 397
+T+ G G+GPE M V I K A + E VDI + A +I R
Sbjct: 10 ITVAYGDGVGPEIMEAVLFILKEARADVSIETVDIGHNQYKKEWTSGIAPSAWESISRTR 69
Query: 398 VGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSY-PGVATRHKDIDVVIIRQNTE 574
+ LK T + + S NVALR L +Y + C SY P V T+H D+DVVIIR+N E
Sbjct: 70 LLLKAPTMTPQGSGH-KSLNVALRQRLGLYVNVRPCVSYFPVVGTKHPDLDVVIIRENEE 128
Query: 575 GEYAMLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKANIMKLSDGL 754
Y+ +EH+ E +K+ T SE++ + R KVT K NIMK++DG+
Sbjct: 129 DTYSGVEHKLSEDTHECVKISTRSASEKICAYAFNYARAHNRKKVTCFVKDNIMKMTDGI 188
Query: 755 FLETSXRLAK 784
+ ++AK
Sbjct: 189 LHASFDKVAK 198
>UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68;
Bacteria|Rep: Isocitrate dehydrogenase -
Janthinobacterium sp. (strain Marseille) (Minibacterium
massiliensis)
Length = 349
Score = 99 bits (238), Expect = 6e-20
Identities = 64/192 (33%), Positives = 99/192 (51%), Gaps = 9/192 (4%)
Frame = +2
Query: 230 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPT-MDNDDDV--QYAITTIKRNGV 400
VT++PG GIGPE + V +F +G P +E ++ D+ Q + +I R G+
Sbjct: 12 VTLIPGDGIGPEIVDVVVRVFDALGNPFAWETQQAGVNALEKSGDLLPQTTLDSIGRTGL 71
Query: 401 GLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSY-PGVATRHKDIDVVIIRQNTEG 577
LKG + T + S NV LR +YA + ++ PG R++ ID+V++R+N EG
Sbjct: 72 ALKGPLSTPIGGGF-RSVNVRLRETFQLYANVRPARTIVPG--GRYEKIDLVLVRENLEG 128
Query: 578 EYAMLEH-----ESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKANIMKL 742
Y EH + + V + + T S R+ +N R KVT VHKAN++K
Sbjct: 129 LYVGHEHYVPIGDDAHAVAMATGINTRAGSRRISKFAFDYAVRNNRRKVTIVHKANVLKA 188
Query: 743 SDGLFLETSXRL 778
GLFLET+ ++
Sbjct: 189 LTGLFLETAKQV 200
>UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Thermoprotei|Rep: 3-isopropylmalate dehydrogenase -
Sulfolobus tokodaii
Length = 337
Score = 96.3 bits (229), Expect = 8e-19
Identities = 67/192 (34%), Positives = 100/192 (52%), Gaps = 7/192 (3%)
Frame = +2
Query: 230 VTMLPGGGIGPECMGYVRDIFKYIGA----PIDF-EVVDIDPTMDNDDDV--QYAITTIK 388
V ++ G GIGPE + + I I PI++ EV D + + + ++ I
Sbjct: 5 VALIQGDGIGPEIVSKSKRILAKINELYSLPIEYIEVEAGDRALARYGEALPKDSLKIID 64
Query: 389 RNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQN 568
+ + LKG + AA V V LR DMYA I KS PG+ T++ ++D++I+R+N
Sbjct: 65 KADIILKGPVG--ESAADVV---VKLRQIYDMYANIRPAKSIPGIDTKYGNVDILIVREN 119
Query: 569 TEGEYAMLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKANIMKLSD 748
TE Y EH +GV MK++T SER+ + R KVT VHKAN+M+++D
Sbjct: 120 TEDLYKGFEHIVSDGVAVGMKIITRFASERIAKVGLNFALRR-RKKVTCVHKANVMRITD 178
Query: 749 GLFLETSXRLAK 784
GLF E + K
Sbjct: 179 GLFAEACRSVLK 190
>UniRef50_Q4UKR1 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=29; cellular organisms|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Rickettsia felis (Rickettsia azadi)
Length = 483
Score = 94.3 bits (224), Expect = 3e-18
Identities = 61/190 (32%), Positives = 95/190 (50%), Gaps = 5/190 (2%)
Frame = +2
Query: 230 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDV----QYAITTIKRNG 397
+T+ G GIGPE M V I + A I E +++ + + + +I+R G
Sbjct: 7 ITIAYGDGIGPEIMEAVLYILRKAEARIRLETIEVGEKLYKKHYTSGISEESWESIQRTG 66
Query: 398 VGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSY-PGVATRHKDIDVVIIRQNTE 574
+ LK I T Y S NV +R L ++A I S+ P T H +++ IIR+N E
Sbjct: 67 IILKAPITTPQGGGY-KSLNVTIRKTLQLFANIRPSVSFHPFTMTLHPHLNLTIIRENEE 125
Query: 575 GEYAMLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKANIMKLSDGL 754
YA +E+ + + ES+K+++ E++ KN R KVT + K NIMK SDG+
Sbjct: 126 DLYAGIEYRQTHNMYESIKLISHTGCEKIIRYAFEYAVKNNRKKVTCLSKDNIMKFSDGV 185
Query: 755 FLETSXRLAK 784
F + +AK
Sbjct: 186 FHKIFNEIAK 195
>UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH).; n=1;
Bos taurus|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH). - Bos Taurus
Length = 260
Score = 91.1 bits (216), Expect = 3e-17
Identities = 44/101 (43%), Positives = 64/101 (63%)
Frame = +2
Query: 479 DMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSER 658
D+ A ++ +S P V TRHK+ID++++R NTEGEY+ LE ES+N VVES++ VT R
Sbjct: 17 DLCANVVQFESQPRVETRHKNIDILVVRDNTEGEYSNLEDESMNRVVESLRTVTKAKCLR 76
Query: 659 VXXXXXXXXXKNGRXKVTTVHKANIMKLSDGLFLETSXRLA 781
+ + G KVT +KANIM+L D LF++ +A
Sbjct: 77 LAEYAFQLAHRMGCKKVTATYKANIMRLGDCLFIQCCREVA 117
>UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]
subunit-like 4 (Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4); n=1; Arabidopsis thaliana|Rep:
Putative isocitrate dehydrogenase [NAD] subunit-like 4
(Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4) - Arabidopsis thaliana
(Mouse-ear cress)
Length = 294
Score = 89.4 bits (212), Expect = 9e-17
Identities = 59/171 (34%), Positives = 90/171 (52%), Gaps = 2/171 (1%)
Frame = +2
Query: 278 VRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRN 457
V + + AP+ FE I N + + +I++N V L G + S
Sbjct: 16 VHQVMDAMQAPVYFETYIIKGKNMNHLTWE-VVDSIRKNKVCLNGRVNN--------SLC 66
Query: 458 VALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKV- 634
R ELD++A +++C + G +RH+++D+V+IR+NTEGEYA EHE V GV+ES +V
Sbjct: 67 GGARKELDLFASLVDCFNLNGQPSRHENVDIVVIRENTEGEYAGREHEVVPGVIESFQVT 126
Query: 635 VTADNSERVXXXXXXXXXKNGRXKVTTVH-KANIMKLSDGLFLETSXRLAK 784
+T S+R+ + R KVT VH KL+D FLE+ +AK
Sbjct: 127 MTKFWSDRIAKYAFEYAHFSKRKKVTAVHNNGKYEKLADAFFLESCQEVAK 177
>UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanobacterium thermoautotrophicum
Length = 329
Score = 86.2 bits (204), Expect = 8e-16
Identities = 55/184 (29%), Positives = 84/184 (45%)
Frame = +2
Query: 230 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLK 409
+ ++PG GIG E M I + ++F D T++ G
Sbjct: 6 IAVIPGDGIGVEVMEAALHILNTLDLDLEFIHADAGDACLKRTGTALPEETLEAVGEARA 65
Query: 410 GNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAM 589
E+A V LR E D++A + KS PGV + D+D VI+R+NTE Y
Sbjct: 66 TLFGAAGESA--ADVIVRLRREFDLFANLRPVKSLPGVPCLYPDLDFVIVRENTEDLYVG 123
Query: 590 LEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKANIMKLSDGLFLETS 769
E + G V + +++T S R+ K G KVT VHKAN++K +DG+F +
Sbjct: 124 DEEYTPEGAV-AKRIITRTASRRISQFAFQYAQKEGMQKVTAVHKANVLKKTDGIFRDEF 182
Query: 770 XRLA 781
++A
Sbjct: 183 YKVA 186
>UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
- Archaeoglobus fulgidus
Length = 326
Score = 82.6 bits (195), Expect = 1e-14
Identities = 54/189 (28%), Positives = 91/189 (48%), Gaps = 4/189 (2%)
Frame = +2
Query: 230 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDI-DPTMDNDDDV--QYAITTIKRNGV 400
+ ++PG GIG E M I + + P ++ D D ++ + +++
Sbjct: 4 IVVIPGDGIGKEVMEAAMLILEKLDLPFEYSYYDAGDEALEKYGKALPDETLEACRKSDA 63
Query: 401 GLKGNI-ETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEG 577
L G ET ++ V LR EL +A + K+ G+ + +D+V++R+NTE
Sbjct: 64 VLFGAAGETAADVI------VRLRRELGTFANVRPAKAIEGIECLYPGLDIVVVRENTEC 117
Query: 578 EYAMLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKANIMKLSDGLF 757
Y E V E+++V+T + SER+ + GR KVT +HKAN+MK + GLF
Sbjct: 118 LYMGFEF-GFGDVTEAIRVITREASERIARYAFELAKREGRKKVTALHKANVMKKTCGLF 176
Query: 758 LETSXRLAK 784
+ +AK
Sbjct: 177 RDVCREVAK 185
>UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanococcus jannaschii
Length = 333
Score = 81.8 bits (193), Expect = 2e-14
Identities = 67/201 (33%), Positives = 98/201 (48%), Gaps = 14/201 (6%)
Frame = +2
Query: 224 HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVG 403
H + ++ G GIG E + + + G P +F + D+V KR G
Sbjct: 2 HKICVIEGDGIGKEVVPATIQVLEATGLPFEFVYAEAG------DEVY------KRTGKA 49
Query: 404 L-KGNIETKSE-------AAYVTSRNVA--LRNELDMYAYILNCKSYPGVATRHKDIDVV 553
L + IET + AA T+ +V LR+ LD YA I K+Y GV DID V
Sbjct: 50 LPEETIETALDCDAVLFGAAGETAADVIVKLRHILDTYANIRPVKAYKGVKCLRPDIDYV 109
Query: 554 IIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERV---XXXXXXXXXKNGR-XKVTTVH 721
I+R+NTEG Y +E E G+ + +V+T ER+ K G+ KVT H
Sbjct: 110 IVRENTEGLYKGIEAEIDEGITIATRVITEKACERIFRFAFNLARERKKMGKEGKVTCAH 169
Query: 722 KANIMKLSDGLFLETSXRLAK 784
KAN++KL+DGLF + ++A+
Sbjct: 170 KANVLKLTDGLFKKIFYKVAE 190
>UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1;
Planctomyces maris DSM 8797|Rep: Isocitrate
dehydrogenase, putative - Planctomyces maris DSM 8797
Length = 390
Score = 81.0 bits (191), Expect = 3e-14
Identities = 64/215 (29%), Positives = 104/215 (48%), Gaps = 28/215 (13%)
Frame = +2
Query: 224 HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDID-PTMDNDDDV-QYAITTIKRNG 397
+ VT++PG G+GPE R G ID++V + ++ + V + +I+ N
Sbjct: 2 YKVTLIPGDGVGPEIAEATRKCVDATGVKIDWDVQECGIEVIEAEGGVPDRVMDSIRANK 61
Query: 398 VGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKD--IDVVIIRQNT 571
+ LK I T + S NV LR EL +YA I CK+Y GV T D +D+V++R+NT
Sbjct: 62 IALKAPITTPIGKGF-RSVNVFLRQELGLYACIRPCKTYKGVRTYFADSNVDLVVVRENT 120
Query: 572 EGEYAMLEHES--------------------VNGVVE----SMKVVTADNSERVXXXXXX 679
E YA +E ++ +N ++ S+K ++ + +
Sbjct: 121 EDLYAGVEFQAGQEKTAELIKKINEFATGKKINTPLDETGVSIKPMSYQGTRDICNYAFK 180
Query: 680 XXXKNGRXKVTTVHKANIMKLSDGLFLETSXRLAK 784
N R VT++ KANIMK +DGL+ + + +AK
Sbjct: 181 YAVDNKRQSVTSICKANIMKFTDGLWYDETRAVAK 215
>UniRef50_Q2Q9C5 Cluster: Isocitrate dehydrogenase 3 gamma; n=8;
Eutheria|Rep: Isocitrate dehydrogenase 3 gamma - Homo
sapiens (Human)
Length = 88
Score = 81.0 bits (191), Expect = 3e-14
Identities = 38/85 (44%), Positives = 55/85 (64%), Gaps = 3/85 (3%)
Frame = +2
Query: 164 HKTP---VIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDI 334
H+ P + +Q + P A+YGGRH VTM+PG GIGPE M +V+ +F++ P+DFE V +
Sbjct: 5 HEVPSRNIFSEQTIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHV 64
Query: 335 DPTMDNDDDVQYAITTIKRNGVGLK 409
D ++D+ AI I+RN V LK
Sbjct: 65 SSNAD-EEDICNAIMAIRRNRVALK 88
>UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase; n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Isopropylmalate/isohomocitrate dehydrogenase -
Candidatus Nitrosopumilus maritimus SCM1
Length = 337
Score = 79.8 bits (188), Expect = 7e-14
Identities = 55/195 (28%), Positives = 98/195 (50%), Gaps = 8/195 (4%)
Frame = +2
Query: 224 HAVTMLPGGGIGPECMGYVRDIFKYIGAPID--FEVVDI---DPTMDNDDDV--QYAITT 382
+ ++++ G GIGPE + + I +D F + + D ++ ++
Sbjct: 2 YKISLITGDGIGPELSDSAVSVLETIHDKLDLKFGITKLSAGDKALEQTGKALPDDTVSA 61
Query: 383 IKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIR 562
IK++ +K + AA V V LR LD+YA I KSYP + DID+VI+R
Sbjct: 62 IKQSDACMKAPVG--ESAADVI---VVLRRMLDLYANIRPAKSYPHMPALRDDIDMVIVR 116
Query: 563 QNTEGEYAMLEHESVNGVVESMKVVTADNSERVX-XXXXXXXXKNGRXKVTTVHKANIMK 739
+NTE Y E S+ ++++++ S+R+ +N + KVT VHK+N+M+
Sbjct: 117 ENTEDLYTGKEF-SLGDSSVALRIISEQASKRIAKYAFETAKMRNDKKKVTCVHKSNVMR 175
Query: 740 LSDGLFLETSXRLAK 784
++DG+F + ++K
Sbjct: 176 VTDGMFAKACTEVSK 190
>UniRef50_Q2UP37 Cluster: Isocitrate/isopropylmalate dehydrogenase;
n=1; Aspergillus oryzae|Rep: Isocitrate/isopropylmalate
dehydrogenase - Aspergillus oryzae
Length = 350
Score = 77.4 bits (182), Expect = 4e-13
Identities = 47/131 (35%), Positives = 75/131 (57%), Gaps = 4/131 (3%)
Frame = +2
Query: 404 LKGNIE-TKSEAAYVT--SRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTE 574
L G I T+++ + VT S N A+R EL+++ + Y G++ RH+ +D+VI+R+ TE
Sbjct: 73 LHGRISCTQTDGSVVTYPSINNAIRRELNLFVNPRPIRGYVGISGRHEKMDMVIMREITE 132
Query: 575 GEYAMLEHESVNGVV-ESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKANIMKLSDG 751
Y E +G E++K VT S +V K+GR KV+ +HKAN++ +DG
Sbjct: 133 DTYIGWEKPLEDGAAAEAIKRVTRSASWKVSQYAFEYARKHGRKKVSCLHKANVLHETDG 192
Query: 752 LFLETSXRLAK 784
LFL T +A+
Sbjct: 193 LFLRTFQEVAR 203
>UniRef50_Q4V533 Cluster: IP13250p; n=4; Drosophila
melanogaster|Rep: IP13250p - Drosophila melanogaster
(Fruit fly)
Length = 475
Score = 76.2 bits (179), Expect = 9e-13
Identities = 45/176 (25%), Positives = 90/176 (51%), Gaps = 1/176 (0%)
Frame = +2
Query: 194 LIPKAQYGGRHAVTMLPGGGI-GPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQY 370
++PK++YGG + V+++ G I G + +V + P++ +V++ DD+ +
Sbjct: 53 VLPKSKYGGINTVSLVTGTTIIGQQGAQFVSSLLSSSRVPVEVQVIEAG----QDDEYFH 108
Query: 371 AITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDV 550
++ RN + + + +EA + + + N+LD+Y + +S+PG R +D+
Sbjct: 109 SVL---RNRTAVHVDNQADAEAK---QKALKICNDLDLYVFKTRTRSFPGFKCRFPGVDI 162
Query: 551 VIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTTV 718
+I QN G + LE+ V GVVE++ VV+ +++ K GR +VT +
Sbjct: 163 QLIGQNNMGIFNELEYSPVEGVVEALSVVSQKGNDKYLRYAFKAAAKAGRKRVTLI 218
>UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Proteobacteria|Rep: 3-isopropylmalate dehydrogenase -
Bradyrhizobium japonicum
Length = 365
Score = 74.5 bits (175), Expect = 3e-12
Identities = 61/215 (28%), Positives = 93/215 (43%), Gaps = 18/215 (8%)
Frame = +2
Query: 194 LIPKAQYGGR-HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQY 370
+ P Q+ G + +LPG GIGPE + + + + + + Q+
Sbjct: 2 IAPALQFWGNVMQLIVLPGDGIGPEITTATSGVLRAASERFQLNLRLEEHAVGHASLKQF 61
Query: 371 AITT------IKRNGVGL----KGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPG 520
T I R GL + K EA + + R LD+YA + ++Y G
Sbjct: 62 GTTVRPELLDIVRGADGLILGPTATFDFKDEAHGEINPSRHFRKNLDLYANVRPARTYAG 121
Query: 521 VATRHKDIDVVIIRQNTEGEYAMLEHESVNG-------VVESMKVVTADNSERVXXXXXX 679
R D D+V++R+NTEG YA E NG V S++ +T ER+
Sbjct: 122 RPGRLGDFDLVVVRENTEGFYADRNMEQGNGEMLVTPDVAISLRRITRACCERIAHAACR 181
Query: 680 XXXKNGRXKVTTVHKANIMKLSDGLFLETSXRLAK 784
K R +T VHKAN++K+ DG+FL+ AK
Sbjct: 182 LAMKR-RRHLTIVHKANVLKIGDGMFLDICRAAAK 215
>UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9;
Euteleostomi|Rep: NAD+-isocitrate dehydrogenase - Homo
sapiens (Human)
Length = 133
Score = 73.3 bits (172), Expect = 6e-12
Identities = 36/105 (34%), Positives = 63/105 (60%), Gaps = 3/105 (2%)
Frame = +2
Query: 218 GRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDID--PTMDNDDDVQYAITTIKR 391
G VTMLPG G+GPE M V+++FK P++F+ + M +++ ++ ++++K
Sbjct: 15 GAFPVTMLPGDGVGPELMHAVKEVFKAASVPVEFQEHHLSEVQNMASEEKLEQVLSSMKE 74
Query: 392 NGVGLKGNIETKSE-AAYVTSRNVALRNELDMYAYILNCKSYPGV 523
N V + G I T E + S ++ LR +LD++A +++ KS PGV
Sbjct: 75 NKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVIHVKSLPGV 119
>UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Methanosaeta thermophila PT|Rep: Isocitrate
dehydrogenase (NAD(+)) - Methanosaeta thermophila
(strain DSM 6194 / PT) (Methanothrixthermophila (strain
DSM 6194 / PT))
Length = 375
Score = 69.7 bits (163), Expect = 8e-11
Identities = 46/143 (32%), Positives = 73/143 (51%), Gaps = 5/143 (3%)
Frame = +2
Query: 371 AITTIKRNGVGLKGNIETKSEA---AYVTSRNVALRNELDMYAYILNCKSYPGVATRHKD 541
A+ +K+ V LKG + T + + S NVA+R ELD++A + V+ +
Sbjct: 75 ALDALKKCHVILKGPLTTPKKGDPWPNLESANVAMRRELDLFANVRP------VSIPSEG 128
Query: 542 IDVVIIRQNTEGEYAMLEH--ESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTT 715
ID V R+NTEGEY + + + KV+T SER+ +N +V+
Sbjct: 129 IDWVFFRENTEGEYVLGSKGFNVTDDLAVDFKVITTQGSERIIRLAFDYARRNNINRVSV 188
Query: 716 VHKANIMKLSDGLFLETSXRLAK 784
V KAN++K +DG FLE + ++K
Sbjct: 189 VTKANVVKTTDGKFLEIARAISK 211
>UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1;
Entamoeba histolytica HM-1:IMSS|Rep: tartrate
dehydrogenase - Entamoeba histolytica HM-1:IMSS
Length = 370
Score = 69.3 bits (162), Expect = 1e-10
Identities = 54/184 (29%), Positives = 90/184 (48%), Gaps = 11/184 (5%)
Frame = +2
Query: 221 RHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVD--IDPTMDNDDDVQY-AITTIKR 391
+H + ++PG GIG E M +F+ + PI + VD I + V I +K+
Sbjct: 10 QHKIIVIPGDGIGAEVMNEAEKMFQSLNLPIQRDYVDWGIQHYLKTGKVVPIDYIDQVKQ 69
Query: 392 NGVGLKGNI-ETKSEAAYVTSRN-VALRNELDMYAYILNCKSYPGVATRHK--DIDVVII 559
L G++ + ++ YVT + +R +LD + + K +PG+ T K +IDV+++
Sbjct: 70 YDAILLGSLGDPRTLPDYVTLEPLIQMRQQLDQFLCLRPAKHFPGIPTPLKKCEIDVLVV 129
Query: 560 RQNTEGEYAMLEHESVNGVVESMKVVTADNS----ERVXXXXXXXXXKNGRXKVTTVHKA 727
R+N+EGEY+ + +G E + +A +S ERV K R VT K+
Sbjct: 130 RENSEGEYSNIGGIFKSGTPEEFAIESAVHSRRGLERVIRYAFEASRKR-RNHVTLATKS 188
Query: 728 NIMK 739
N MK
Sbjct: 189 NAMK 192
>UniRef50_Q58991 Cluster: Threo-isocitrate dehydrogenase [NAD]; n=9;
Methanococcales|Rep: Threo-isocitrate dehydrogenase
[NAD] - Methanococcus jannaschii
Length = 347
Score = 68.5 bits (160), Expect = 2e-10
Identities = 34/83 (40%), Positives = 49/83 (59%)
Frame = +2
Query: 536 KDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTT 715
K+ID+VIIR+NTE Y E N + +V+T SER+ KN R KV+
Sbjct: 120 KNIDIVIIRENTEDLYVGRERLE-NDTAIAERVITRKGSERIIRFAFEYAIKNNRKKVSC 178
Query: 716 VHKANIMKLSDGLFLETSXRLAK 784
+HKAN+++++DGLFLE + K
Sbjct: 179 IHKANVLRITDGLFLEVFNEIKK 201
>UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;
n=1; Ignicoccus hospitalis KIN4/I|Rep: 3-isopropylmalate
dehydrogenase - Ignicoccus hospitalis KIN4/I
Length = 343
Score = 67.3 bits (157), Expect = 4e-10
Identities = 55/192 (28%), Positives = 91/192 (47%), Gaps = 12/192 (6%)
Frame = +2
Query: 230 VTMLPGGGIGPECMGYVRDIFKYIGA----PIDFEVVDI-DPTMDNDDDV--QYAITTIK 388
V ++ G GIGPE +G + + I P++F V+ D + + + + +
Sbjct: 4 VAVIEGDGIGPEVVGATLKVLEKIRETFKLPLEFVFVEAGDRAKEKYGEALPKESYERLL 63
Query: 389 RNGVGLKGNI-ETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQ 565
R LKG + ET ++ V LR ELD++A I K PGV +++D++I+R+
Sbjct: 64 RADAILKGPVGETAADVI------VRLRRELDLFANIRPAKVLPGVPALKENVDLIIVRE 117
Query: 566 NTEGEYA----MLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKANI 733
N E Y +L S+ V + ++ R K R KVT VHKAN+
Sbjct: 118 NIEDLYVGAENLLPQTSLGHKVAVGLRLASERETRRVAKVAAEYAKARRNKVTIVHKANV 177
Query: 734 MKLSDGLFLETS 769
M+++ GLF + +
Sbjct: 178 MRVTCGLFRDVA 189
>UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2;
Alphaproteobacteria|Rep: Isopropylmalate dehydrogenase -
Oceanicola granulosus HTCC2516
Length = 363
Score = 65.7 bits (153), Expect = 1e-09
Identities = 36/114 (31%), Positives = 56/114 (49%), Gaps = 7/114 (6%)
Frame = +2
Query: 464 LRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEG-------EYAMLEHESVNGVVE 622
LR D++A + +SYPG+ DID+VI+R+N EG E V
Sbjct: 95 LRKGFDLFANVRPTRSYPGIGCLFDDIDLVIVRENNEGFQPDRNVVAGSGEFRPTEDVTI 154
Query: 623 SMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKANIMKLSDGLFLETSXRLAK 784
S++V+T + +V R K+T VHK + KL G+F++T+ +AK
Sbjct: 155 SVRVITVEGCRKVVRAALDIARSRPRKKLTLVHKNTVFKLGCGMFVDTAYEVAK 208
>UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenase
family protein; n=6; Archaea|Rep:
Isocitrate/isopropylmalate dehydrogenase family protein
- Methanosarcina acetivorans
Length = 342
Score = 64.9 bits (151), Expect = 2e-09
Identities = 42/188 (22%), Positives = 84/188 (44%), Gaps = 5/188 (2%)
Frame = +2
Query: 236 MLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITT-----IKRNGV 400
++ G G+GPE + + + G ++F + + + + + +
Sbjct: 7 VIKGDGVGPELVEAMLKVANAAGTDVEFVMCEAGAGWWEEHGGNSLVPDETWQILDSSDA 66
Query: 401 GLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGE 580
KG T S V++R + D+YA + K++P D+++V +R+ TEG
Sbjct: 67 CFKGPTTTPGGIGSPRSVAVSIRRKYDLYANVRPIKTFPNSNAPLGDVEMVCVREGTEGL 126
Query: 581 YAMLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKANIMKLSDGLFL 760
Y E + + V +++ +T S ++ + G V +HK+NI+KL+ G FL
Sbjct: 127 YIGEEIQLTDDVSIAIRKITRTASGKIARYAFEEAKRRGYDTVVPIHKSNILKLTCGSFL 186
Query: 761 ETSXRLAK 784
E ++A+
Sbjct: 187 EEVEKVAQ 194
>UniRef50_Q0W1Q6 Cluster: 2-isopropylmalate dehydrogenase; n=5;
Euryarchaeota|Rep: 2-isopropylmalate dehydrogenase -
Uncultured methanogenic archaeon RC-I
Length = 324
Score = 64.9 bits (151), Expect = 2e-09
Identities = 56/188 (29%), Positives = 91/188 (48%), Gaps = 3/188 (1%)
Frame = +2
Query: 230 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYA---ITTIKRNGV 400
+ +LPG GIG E + ++ K +F V++ + V + + T+K
Sbjct: 3 IAVLPGDGIGREVVPVAHEVLKVALPDAEFLHVEVGNERYVREGVSMSPADLETVKACDC 62
Query: 401 GLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGE 580
L G I + Y S + LR ELD+YA I +S P ++ R ++ I R+N+E
Sbjct: 63 VLFGAITSPPGKPY-RSIILTLRKELDLYANIRPFRSCP-ISPR--KVNFTIYRENSEDL 118
Query: 581 YAMLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKANIMKLSDGLFL 760
Y +E E S++V+T SER+ K G K+T VHK+N++K +D LF
Sbjct: 119 YMGIE-EITGDEARSVRVITRKASERI---ARAACSKPGIGKLTIVHKSNVLK-ADELFK 173
Query: 761 ETSXRLAK 784
+ ++AK
Sbjct: 174 DACAQVAK 181
>UniRef50_Q5HNL1 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=73; cellular organisms|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Staphylococcus epidermidis (strain ATCC 35984 /
RP62A)
Length = 422
Score = 63.7 bits (148), Expect = 5e-09
Identities = 51/165 (30%), Positives = 78/165 (47%), Gaps = 26/165 (15%)
Frame = +2
Query: 365 QYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT---RH 535
Q + TIK + +KG + T + S NVALR ELD++ + + + GV + R
Sbjct: 76 QETLETIKEYLIAVKGPLTTPIGGG-IRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRP 134
Query: 536 KDIDVVIIRQNTEGEYAMLEHE----SVNGVVE-------------------SMKVVTAD 646
+D+D+VI R+NTE YA +E + V V++ +K V+ +
Sbjct: 135 EDVDMVIFRENTEDIYAGIEFKQGTSEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKE 194
Query: 647 NSERVXXXXXXXXXKNGRXKVTTVHKANIMKLSDGLFLETSXRLA 781
+ER+ N R VT VHK NIMK ++G F + LA
Sbjct: 195 GTERLVRAAIQYALDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLA 239
>UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodococcus sp. (strain RHA1)
Length = 365
Score = 60.9 bits (141), Expect = 4e-08
Identities = 38/105 (36%), Positives = 56/105 (53%), Gaps = 7/105 (6%)
Frame = +2
Query: 464 LRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNG-------VVE 622
+R D++A I +S GVA+ D+D+VI+R+NTEG YA + +G V
Sbjct: 102 VRKRFDLFANIRPARSLEGVASTVPDMDLVIVRENTEGLYADRNMFAGSGEFMPTPDVAL 161
Query: 623 SMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKANIMKLSDGLF 757
++ VVT ER+ GR VT VHKAN++ ++ GLF
Sbjct: 162 AVGVVTRKACERIAHTAFALARTRGR-HVTIVHKANVLSMTTGLF 205
>UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Chloroflexi (class)|Rep: 3-isopropylmalate dehydrogenase
- Roseiflexus sp. RS-1
Length = 362
Score = 59.3 bits (137), Expect = 1e-07
Identities = 57/204 (27%), Positives = 90/204 (44%), Gaps = 17/204 (8%)
Frame = +2
Query: 224 HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDI--DPTMDNDDDVQYAITTIKRNG 397
+ + ++PG GIG E + + + G P FE D + + + A T R
Sbjct: 6 YTILVIPGDGIGREVIPAAVAVLRATGLPFHFENADAGWECFQRQGEALPSATLTAARAA 65
Query: 398 VG-LKGNIETKS-EAAYVTSRNVALRNELDMYAYILNC-KSYP--GVATRHKDIDVVIIR 562
L G + + A S V LR ELD+YA I P G R + +D+V++R
Sbjct: 66 DAILFGAVASPGYPVAGYRSPIVRLRRELDLYANIRPVFDDLPENGSNPRRRKVDLVVVR 125
Query: 563 QNTEGEYAMLEHESVNGVVE-SMKVVTADNSERVXXXX-----XXXXXKNGRX----KVT 712
+NTE YA E +G + +V+T S R+ +NG +VT
Sbjct: 126 ENTEDVYAGRERVEDDGATAIAERVITRRASARIMRVACDLARARRSARNGSDAPPGRVT 185
Query: 713 TVHKANIMKLSDGLFLETSXRLAK 784
VHKAN+++ + GLF + +A+
Sbjct: 186 VVHKANVLRETCGLFRSVALEVAQ 209
>UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Thermoproteaceae|Rep: 3-isopropylmalate dehydrogenase -
Pyrobaculum aerophilum
Length = 290
Score = 59.3 bits (137), Expect = 1e-07
Identities = 38/109 (34%), Positives = 58/109 (53%)
Frame = +2
Query: 431 EAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVN 610
E+AY + + +R L YA I K+ PGV ++ID V +R+N E Y E++ V
Sbjct: 41 ESAYDVTSLIRMRYTL--YANIRPVKNLPGVPAV-REIDCVFVRENVEDVYVGAEYK-VG 96
Query: 611 GVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKANIMKLSDGLF 757
V ++KV+T + RV R +VT VHKAN++++ DG F
Sbjct: 97 DVAIALKVITEKGTRRVARMARKYAEMR-RRRVTIVHKANVLRVVDGFF 144
>UniRef50_Q9RTT2 Cluster: Isocitrate dehydrogenase, putative; n=2;
Deinococcus|Rep: Isocitrate dehydrogenase, putative -
Deinococcus radiodurans
Length = 333
Score = 58.4 bits (135), Expect = 2e-07
Identities = 30/101 (29%), Positives = 58/101 (57%)
Frame = +2
Query: 464 LRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTA 643
LR + ++YA + K+ P V ++++D+VI+R+NT+G Y E + + V+T
Sbjct: 89 LRQKYNLYANVRPTKTRP-VPHSYENVDLVIVRENTQGLYVEQERRYGDTAIADT-VITR 146
Query: 644 DNSERVXXXXXXXXXKNGRXKVTTVHKANIMKLSDGLFLET 766
+ S+R+ K + ++T VHK+N++ ++ GLF+ T
Sbjct: 147 EASDRIGKFAADLAMKRSK-RLTVVHKSNVLPVTQGLFMNT 186
>UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase,
mitochondrial precursor; n=33; Dikarya|Rep:
Homoisocitrate dehydrogenase, mitochondrial precursor -
Saccharomyces cerevisiae (Baker's yeast)
Length = 371
Score = 58.4 bits (135), Expect = 2e-07
Identities = 49/196 (25%), Positives = 92/196 (46%), Gaps = 18/196 (9%)
Frame = +2
Query: 230 VTMLPGGGIGPECMGYVRDIFKYIGAP--IDFEVVDIDPTMDNDDDVQYA-----ITTIK 388
+ ++PG GIG E + + + + + + + F +D+ + A + +K
Sbjct: 26 IGLIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFIDLYAGFQTFQETGKALPDETVKVLK 85
Query: 389 RNGVG-LKGNIETKS-EAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIR 562
G L G +++ + + +S VALR E+ ++A + KS G + K ID+VI+R
Sbjct: 86 EQCQGALFGAVQSPTTKVEGYSSPIVALRREMGLFANVRPVKSVEG--EKGKPIDMVIVR 143
Query: 563 QNTEGEYAMLEHESVNG-----VVESMKVVTADNSERVXXXXXXXXXKN----GRXKVTT 715
+NTE Y +E ++ V ++ K ++ + R+ K G+ +T
Sbjct: 144 ENTEDLYIKIEKTYIDKATGTRVADATKRISEIATRRIATIALDIALKRLQTRGQATLTV 203
Query: 716 VHKANIMKLSDGLFLE 763
HK+N++ SDGLF E
Sbjct: 204 THKSNVLSQSDGLFRE 219
>UniRef50_Q8XSY8 Cluster: Probable 3-isopropylmalate dehydrogenase
oxidoreductase protein; n=1; Ralstonia solanacearum|Rep:
Probable 3-isopropylmalate dehydrogenase oxidoreductase
protein - Ralstonia solanacearum (Pseudomonas
solanacearum)
Length = 365
Score = 57.6 bits (133), Expect = 3e-07
Identities = 59/215 (27%), Positives = 98/215 (45%), Gaps = 30/215 (13%)
Frame = +2
Query: 230 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLK 409
+ +LP GIGPE +G ++ + + V +D D DD T++++ G L+
Sbjct: 3 ILVLPCDGIGPEIVGAAMEVLRSADS-----VFKLDLAFDYDD---VGFTSLEKYGTTLR 54
Query: 410 GNI------------ETKSEAAYVT----SRNVA--LRNELDMYAYILNCKSYPGVATRH 535
+ T+S A Y RNV+ R LD+YA + ++ P + +
Sbjct: 55 DEVLAKAKTYDGVILGTQSHADYPAPDKGGRNVSAGFRIGLDLYANVRPARTRPFLTSNM 114
Query: 536 KD---IDVVIIRQNTEGEYAMLEHESVNGVVE---------SMKVVTADNSERVXXXXXX 679
++ +D+VI+R+ TEG Y + G E S++ +T SER+
Sbjct: 115 REGRTMDLVIMREATEGFYP--DRNMTKGWAELMPSPDMAISLRKITRHCSERIARRAFE 172
Query: 680 XXXKNGRXKVTTVHKANIMKLSDGLFLETSXRLAK 784
K + KVT +HKAN ++DGLFLE +A+
Sbjct: 173 LAMKR-KKKVTAIHKANSFHMTDGLFLECVRDVAR 206
>UniRef50_Q2VF40 Cluster: Isocitrate dehydrogenase 3 gamma subunit;
n=1; Pan troglodytes|Rep: Isocitrate dehydrogenase 3
gamma subunit - Pan troglodytes (Chimpanzee)
Length = 165
Score = 57.2 bits (132), Expect = 4e-07
Identities = 24/37 (64%), Positives = 30/37 (81%)
Frame = +2
Query: 200 PKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAP 310
P A+YGGRH VTM+PG GIGPE M +V+ +F+Y GAP
Sbjct: 105 PSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRY-GAP 140
>UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=38; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Synechocystis sp. (strain PCC 6803)
Length = 475
Score = 57.2 bits (132), Expect = 4e-07
Identities = 34/99 (34%), Positives = 51/99 (51%), Gaps = 3/99 (3%)
Frame = +2
Query: 374 ITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHK---DI 544
+T IK GV +KG + T + S NVALR D+Y + C+ YPG + HK +
Sbjct: 89 LTAIKEYGVAIKGPLTTPVGGG-IRSLNVALRQIFDLYTCVRPCRYYPGTPSPHKTPEKL 147
Query: 545 DVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERV 661
D+++ R+NTE Y L E G + K++ N E +
Sbjct: 148 DIIVYRENTEDIY--LGIEWAEGTEGAKKLIAYLNDELI 184
>UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep: Isocitrate
dehydrogenase (NAD(+)) - Candidatus Nitrosopumilus
maritimus SCM1
Length = 343
Score = 55.2 bits (127), Expect = 2e-06
Identities = 44/187 (23%), Positives = 78/187 (41%), Gaps = 7/187 (3%)
Frame = +2
Query: 236 MLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTM---DNDDDVQY----AITTIKRN 394
++ G GIGPE + + + K + + + + D Y + ++
Sbjct: 7 VMKGDGIGPEVVDSMLRVLKECNFQSELILCEAGSEQWDKNGRKDASYIPDVTMKILEET 66
Query: 395 GVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTE 574
KG T S V LR + D+YA I K+Y + T + +D V R+ TE
Sbjct: 67 DCCFKGPTTTIPVPGAPRSVAVTLRQKFDLYANIRPTKTYDRL-TPDRKLDCVCFREATE 125
Query: 575 GEYAMLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKANIMKLSDGL 754
G Y +E + + +++ +T S R+ K K+ V K NI+K +DG+
Sbjct: 126 GLYTGVEAKITDDAAIAIRKITRQGSRRLIDSAVDWANKFNMKKMVAVTKRNILKQTDGI 185
Query: 755 FLETSXR 775
F + + +
Sbjct: 186 FWDETQK 192
>UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=2; Archaea|Rep: Isocitrate dehydrogenase,
NADP-dependent - Halorubrum lacusprofundi ATCC 49239
Length = 463
Score = 54.8 bits (126), Expect = 2e-06
Identities = 47/163 (28%), Positives = 74/163 (45%), Gaps = 26/163 (15%)
Frame = +2
Query: 374 ITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKD---I 544
++ I+ + V +KG + T A + S NVALR LD+YA + GV + K+ +
Sbjct: 131 VSAIRDHRVAIKGPLTTPVGAGF-RSLNVALRKTLDLYANVRPTYYLDGVPSPVKNPEKM 189
Query: 545 DVVIIRQNTEGEYAMLEHESVNGVVE-----------------------SMKVVTADNSE 655
D++ R+NTE YA +E E+ VE +K ++ S+
Sbjct: 190 DMITFRENTEDVYAGIEWEAGTDEVEQVRDFLEDDMEIADVIHDGPVGIGVKPISEFGSK 249
Query: 656 RVXXXXXXXXXKNGRXKVTTVHKANIMKLSDGLFLETSXRLAK 784
R+ N R VT VHK NIMK ++G F + +A+
Sbjct: 250 RLIREAIDYALANDRDSVTLVHKGNIMKFTEGAFRDWGYEVAE 292
>UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;
n=4; Thermococcaceae|Rep: LeuB-2 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 346
Score = 52.4 bits (120), Expect = 1e-05
Identities = 52/194 (26%), Positives = 86/194 (44%), Gaps = 7/194 (3%)
Frame = +2
Query: 224 HAVTMLPGGGIGPECM-------GYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITT 382
+ V ++ G GIGPE + V D ++ FEV + ++DD++
Sbjct: 2 YRVAVIKGDGIGPEVVDSAIRVVNSVTDRIRFYEFEGGFEVFKRIGSPISEDDLK----E 57
Query: 383 IKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIR 562
I++ L G T S V LR ELD+YA N + P ++ ++VI+R
Sbjct: 58 IRKMDAILFGATTTPFNVPGYRSLIVTLRKELDLYA---NLRIIPDLSNGK---EIVIVR 111
Query: 563 QNTEGEYAMLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKANIMKL 742
+NTEG YA + + +++T + + R+ K +T VHKAN++K
Sbjct: 112 ENTEGLYAR-DGIGFSDRAIDFRIITLEGARRI-AKFAINLAKERNSFITFVHKANVLK- 168
Query: 743 SDGLFLETSXRLAK 784
D F E +A+
Sbjct: 169 GDRFFREIVLEIAE 182
>UniRef50_A1SM34 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Nocardioides sp. JS614|Rep: 3-isopropylmalate
dehydrogenase - Nocardioides sp. (strain BAA-499 /
JS614)
Length = 478
Score = 51.6 bits (118), Expect = 2e-05
Identities = 51/192 (26%), Positives = 76/192 (39%), Gaps = 19/192 (9%)
Frame = +2
Query: 218 GRHAVTMLPGGGIGPECMGYVRDIFKYIG-APIDFEVVDIDPTMDN--------DDDVQY 370
G + ++PG GIGPE + + A + FE D + D V
Sbjct: 130 GSLRLAVIPGDGIGPEVTAEALKVLEVASPAGVKFEQTRYDLGAERYLATGEVLPDSVLE 189
Query: 371 AIT---TIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT---R 532
I I VG K N + LR ELD Y + + +PGVA+
Sbjct: 190 EIREHDAILLGAVGGKPNDPNLPPGILERGLLLRLRFELDHYVNLRPSRIFPGVASPLAN 249
Query: 533 HKDIDVVIIRQNTEGEYA----MLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGR 700
++D V++R+ TEG Y L + + + + V TA ERV + R
Sbjct: 250 PGEVDFVVVREGTEGPYTGNGGALRVGTPHEIATEVSVNTAFGVERVVRDAFARAQRRPR 309
Query: 701 XKVTTVHKANIM 736
K+T VHK N++
Sbjct: 310 KKLTLVHKTNVL 321
>UniRef50_O29610 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=15; Archaea|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Archaeoglobus fulgidus
Length = 412
Score = 51.6 bits (118), Expect = 2e-05
Identities = 48/160 (30%), Positives = 73/160 (45%), Gaps = 23/160 (14%)
Frame = +2
Query: 374 ITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT--RHKD-I 544
+ IK V LKG + T Y S NV +R LD+YA + GV + +H + +
Sbjct: 85 LNAIKEFRVALKGPLTTPVGGGY-RSLNVTIRQVLDLYANVRPVYYLKGVPSPIKHPEKV 143
Query: 545 DVVIIRQNTEGEYAMLE-----HESVN---------GVVE------SMKVVTADNSERVX 664
+ VI R+NTE YA +E E++ GV +K ++ ++R+
Sbjct: 144 NFVIFRENTEDVYAGIEWPRGSEEALKLIRFLKNEFGVTIREDSGIGIKPISEFATKRLV 203
Query: 665 XXXXXXXXKNGRXKVTTVHKANIMKLSDGLFLETSXRLAK 784
+N R VT VHK NIMK ++G F + +AK
Sbjct: 204 RMAIRYAIENNRKSVTLVHKGNIMKYTEGAFRDWGYEVAK 243
>UniRef50_A5DIP7 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 173
Score = 51.2 bits (117), Expect = 3e-05
Identities = 42/104 (40%), Positives = 52/104 (50%)
Frame = -1
Query: 522 TPG*DLQFSM*AYMSSSFLRATLRDVT*AASLLVSMLPFSPTPFLLMVVIAYWTSSSLSI 343
TPG L + A +S+SFL AT D+ + V+ +PF+PT FL A T LS
Sbjct: 8 TPGMFLIKTNEAKISNSFLNATFNDLP-DDPVGVNKIPFNPTLFLFNDSTASATPVPLS- 65
Query: 342 VGSMSTTSKSIGAPMYLNMSRTYPMHSGPIPPPGSMVTA*RPPY 211
ST S S+G L M T + S PIP PG VT PPY
Sbjct: 66 KPETSTVSHSMGTFSDLKMVLTESVISLPIPSPGMRVTVYLPPY 109
>UniRef50_P41566 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 106
Score = 46.8 bits (106), Expect(2) = 4e-05
Identities = 24/58 (41%), Positives = 30/58 (51%)
Frame = +2
Query: 185 KQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDD 358
+Q + P A+YGG VTM PG G GPE M V P+DFE V + D +D
Sbjct: 3 QQTIPPSAKYGGILTVTMSPGDGDGPELMLTVXXXXXSACVPVDFEEVVVSSNADEED 60
Score = 23.8 bits (49), Expect(2) = 4e-05
Identities = 8/20 (40%), Positives = 14/20 (70%)
Frame = +2
Query: 464 LRNELDMYAYILNCKSYPGV 523
+R LD+YA +++CK G+
Sbjct: 61 IRTSLDLYANVIHCKLGDGL 80
>UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=504; root|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Helicobacter pylori (Campylobacter pylori)
Length = 425
Score = 50.8 bits (116), Expect = 4e-05
Identities = 42/162 (25%), Positives = 71/162 (43%), Gaps = 25/162 (15%)
Frame = +2
Query: 374 ITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSY--PGVATRHKDID 547
I I V +KG + T + S NVALR ++D+Y + + Y P + +D
Sbjct: 99 IEAINHYKVSIKGPLTTPIGEGF-RSLNVALRQKMDLYVCLRPVRWYGSPSPVKEPQKVD 157
Query: 548 VVIIRQNTEGEYAMLEHESVNGVVESM-----------------------KVVTADNSER 658
+VI R+N+E YA +E + + + + K ++ + +ER
Sbjct: 158 MVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVKKIRFPESSGIGVKPISKEGTER 217
Query: 659 VXXXXXXXXXKNGRXKVTTVHKANIMKLSDGLFLETSXRLAK 784
+ N + VT VHK NIMK ++G F++ LA+
Sbjct: 218 LVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQ 259
>UniRef50_Q9CKK6 Cluster: Idp; n=2; Pasteurellaceae|Rep: Idp -
Pasteurella multocida
Length = 415
Score = 50.0 bits (114), Expect = 7e-05
Identities = 45/163 (27%), Positives = 74/163 (45%), Gaps = 26/163 (15%)
Frame = +2
Query: 374 ITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT--RHKD-I 544
+T I+ V +KG + T + S NVA+R LD+Y + + Y G + +H + +
Sbjct: 89 MTFIRDYHVAIKGPLMTPVGGG-IRSLNVAMRQGLDLYNCLRPIRYYDGTPSPVKHPELV 147
Query: 545 DVVIIRQNTEGEYAMLE----HESVNGVVE-------------------SMKVVTADNSE 655
D+VI R+N+E YA +E N V+ +K V+ ++
Sbjct: 148 DMVIFRENSEDIYAGVEWVAGSAEANKVIAFLQQEMGVKKIRFTEDCGIGIKPVSKQGTQ 207
Query: 656 RVXXXXXXXXXKNGRXKVTTVHKANIMKLSDGLFLETSXRLAK 784
R+ N R +T VHK NIMK ++G F E ++A+
Sbjct: 208 RLVRAALQYVIDNDRKSLTLVHKGNIMKFTEGAFKEWGYQVAQ 250
>UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for
NADP+; n=3; Alteromonadales|Rep: Isocitrate
dehydrogenase, specific for NADP+ - Alteromonadales
bacterium TW-7
Length = 422
Score = 50.0 bits (114), Expect = 7e-05
Identities = 43/174 (24%), Positives = 76/174 (43%), Gaps = 28/174 (16%)
Frame = +2
Query: 347 DNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVA 526
D D Q I ++ + +KG + T + S NVALR E+D++ + K + +
Sbjct: 81 DGDWFPQETIQAVRACKIAIKGPLTTPLGGGF-RSLNVALRQEMDLFVNMRTIKGFSALP 139
Query: 527 TRHKD---IDVVIIRQNTEGEYAMLEHESVNGVVESMKV--------------------- 634
+ K+ ++ ++R ++E Y+ +E ++ G +ES K+
Sbjct: 140 SPLKNPFLTNITVLRDSSEDVYSGIEWQA--GSIESEKMLDFLCEEMGVTRLRFSQDCGI 197
Query: 635 ----VTADNSERVXXXXXXXXXKNGRXKVTTVHKANIMKLSDGLFLETSXRLAK 784
++ + SER+ N R VT VHK N++K +DG F LAK
Sbjct: 198 GIKNISKEGSERLTRFALNFALNNNRDSVTFVHKGNVLKFTDGAFKRWGFALAK 251
>UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase;
n=106; Bacteria|Rep: Tartrate
dehydrogenase/decarboxylase - Pseudomonas putida
Length = 365
Score = 48.8 bits (111), Expect = 2e-04
Identities = 34/102 (33%), Positives = 48/102 (47%), Gaps = 9/102 (8%)
Frame = +2
Query: 467 RNELDMYAYILNCKSYPGV----ATRHK-DIDVVIIRQNTEGEYAMLE----HESVNGVV 619
R E D Y I + +PGV A R DID V++R+NTEGEY+ L + N +V
Sbjct: 98 RREFDQYVNIRPVRLFPGVPCALANRKVGDIDFVVVRENTEGEYSSLGGIMFENTENEIV 157
Query: 620 ESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKANIMKLS 745
+ T +R+ K R VT+ K+N M +S
Sbjct: 158 IQESIFTRRGVDRILKYAFDLAEKRERKHVTSATKSNGMAIS 199
>UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;
n=4; cellular organisms|Rep: LeuB-1 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 354
Score = 48.4 bits (110), Expect = 2e-04
Identities = 50/192 (26%), Positives = 81/192 (42%), Gaps = 16/192 (8%)
Frame = +2
Query: 230 VTMLPGGGIGPECMGYVRDIFKYIG--APIDFEVVDI----DPTMDNDDDV-QYAITTIK 388
+ ++PG GIG E + + K + + + FE + + + + + +AI K
Sbjct: 5 IAVIPGDGIGKEVVAEGLKVLKKLEELSRVSFEFKEYPFGAEHYLKTGETLPDWAIEEFK 64
Query: 389 RNGVGLKGNIETKSEAAYVTSRNVAL--RNELDMYAYILNCKSYPGVATRHKD---IDVV 553
+ G I + R + L R ELD+Y + K Y T K ID+V
Sbjct: 65 KFDAIYFGAIGDPRVKPGILERGILLKMRFELDLYVNLRPVKLYHPRLTPLKGKNKIDIV 124
Query: 554 IIRQNTEGEYA----MLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVH 721
+R+NTEG YA L + + + T ERV ++GR KVT V
Sbjct: 125 FVRENTEGLYAGAGGFLRKGTPQEIAVQEMINTRFGVERVIRFAFEYAKRSGRKKVTLVD 184
Query: 722 KANIMKLSDGLF 757
KAN++ + L+
Sbjct: 185 KANVLTYAHDLW 196
>UniRef50_A5URE6 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=4; Chloroflexaceae|Rep: Isocitrate dehydrogenase,
NADP-dependent - Roseiflexus sp. RS-1
Length = 453
Score = 46.8 bits (106), Expect = 6e-04
Identities = 31/83 (37%), Positives = 48/83 (57%), Gaps = 3/83 (3%)
Frame = +2
Query: 398 VGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT---RHKDIDVVIIRQN 568
VG+KG + T + S NVALR LD+Y + + + GV + R + +D+VI R+N
Sbjct: 95 VGIKGPLTTPVGRG-IRSLNVALRQLLDLYVCLRPVRYFQGVPSPVKRPELVDMVIFREN 153
Query: 569 TEGEYAMLEHESVNGVVESMKVV 637
TE YA +E+ + G E+ KV+
Sbjct: 154 TEDIYAGIEYAA--GTPEAQKVL 174
Score = 35.1 bits (77), Expect = 2.0
Identities = 22/70 (31%), Positives = 34/70 (48%), Gaps = 3/70 (4%)
Frame = +2
Query: 584 AMLEHESVNGVVE---SMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKANIMKLSDGL 754
++L + G VE +K V+ +ER+ + R VT VHK NIMK ++G
Sbjct: 201 SLLGNGDGEGAVEVGIGIKPVSRLGTERLVAAAIQYAITHRRRSVTFVHKGNIMKFTEGA 260
Query: 755 FLETSXRLAK 784
F + LA+
Sbjct: 261 FRDWGYALAE 270
>UniRef50_Q0X0C1 Cluster: Putative dehydrogenase; n=1; Streptomyces
lasaliensis|Rep: Putative dehydrogenase - Streptomyces
lasaliensis
Length = 362
Score = 46.4 bits (105), Expect = 8e-04
Identities = 48/192 (25%), Positives = 82/192 (42%), Gaps = 14/192 (7%)
Frame = +2
Query: 206 AQYGGRHAVT---MLPGGGIGPECMGYVRDIFKYIGAPIDFEVVD---IDPTMDNDDDVQ 367
A+ G AVT ++PG GIGPE + D+ +G +++D D + + +
Sbjct: 11 ARAGSETAVTTIAVIPGDGIGPEVIEPALDVLDALGLGTRTDILDHVNADTYLRTGEALT 70
Query: 368 YA-ITTIKRNGVGLKGNIETK--SEAAYVTSRNVALRNELDMY-----AYILNCKSYPGV 523
+ + I+ + L G + + +YV LR ELD+Y A + + + P
Sbjct: 71 GSDLDRIRSSEAALLGAVGDPRLGDTSYVRGVLTTLRLELDLYVNYRPARLWHDRLSPLR 130
Query: 524 ATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRX 703
+ ID VI+R+NTEG Y+ + + G E + V ++ R
Sbjct: 131 DPARRAIDCVIVRENTEGLYSGIGGGARTGTPEEIAVDVDLSTRHGVSRVLEFAFSAARR 190
Query: 704 KVTTVHKANIMK 739
V V KAN ++
Sbjct: 191 SVCLVDKANAVR 202
>UniRef50_A7T3D9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 419
Score = 46.4 bits (105), Expect = 8e-04
Identities = 31/94 (32%), Positives = 51/94 (54%), Gaps = 3/94 (3%)
Frame = +2
Query: 365 QYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHK-- 538
Q + +K V +KG + T + S NVALR +LD+Y + + + GV + K
Sbjct: 88 QETLDAVKDYVVSIKGPLTTPVGGG-IRSLNVALRQQLDLYVCLRPVRWFEGVPSPVKKP 146
Query: 539 -DIDVVIIRQNTEGEYAMLEHESVNGVVESMKVV 637
D+D+ I R+N+E YA +E ++ G E+ KV+
Sbjct: 147 GDVDMTIFRENSEDIYAGIEWKA--GSPEATKVI 178
>UniRef50_A5DIP6 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 230
Score = 46.0 bits (104), Expect = 0.001
Identities = 33/103 (32%), Positives = 44/103 (42%)
Frame = -3
Query: 763 LQE*AIG*LHDVGFVNRCYLXPAVXXXXXXXXXGHPLRVVSCHHFH*LDHTIHGFVFQHS 584
L E I HD+G V+ V G L H H L+HT VFQ
Sbjct: 32 LTEQTISQFHDIGLVDGGDQLTVVLLGKVKCKLGDSLGFEPGHDLHRLNHTRVRLVFQSR 91
Query: 583 VFTFCVLSDNNNINVLMSGRNARVRFTVQYVSIHVQFVSESHI 455
+FTF V SD +N L + +A F S ++QF S+ +I
Sbjct: 92 IFTFSVFSDEGKVNALQTRLDAGNVFDQDQRSKNIQFFSQRNI 134
>UniRef50_Q8U299 Cluster: 3-isopropylmalate dehydrogenase 2; n=3;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
2 - Pyrococcus furiosus
Length = 355
Score = 43.2 bits (97), Expect = 0.008
Identities = 35/105 (33%), Positives = 46/105 (43%), Gaps = 7/105 (6%)
Frame = +2
Query: 464 LRNELDMYAYILNCKSYPGVATRHKD---IDVVIIRQNTEGEYA----MLEHESVNGVVE 622
LR LD+Y + K Y T K ID+V IR+NTEG YA L + + V
Sbjct: 91 LRFSLDLYVNLRPVKLYHPKLTPLKGKEKIDMVFIRENTEGLYAGAGGFLRKGTPHEVAI 150
Query: 623 SMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKANIMKLSDGLF 757
+ T ER GR KVT V KAN++ + L+
Sbjct: 151 QEMINTRFGVERTIRFAFEYAKTKGRKKVTLVDKANVLTYAHDLW 195
>UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: LeuB
protein - Bradyrhizobium japonicum
Length = 359
Score = 41.5 bits (93), Expect = 0.023
Identities = 33/105 (31%), Positives = 53/105 (50%), Gaps = 11/105 (10%)
Frame = +2
Query: 458 VALRNELDMYAYILNCKSYPGVAT---RHKDIDVVIIRQNTEGEYA-------MLEHESV 607
+ LR +LD++A + K Y GV + R ID VI+R+N+EG YA + E +V
Sbjct: 93 LTLRFKLDLFANVRPIKLYKGVPSPLGRPGPIDYVIVRENSEGLYAARGAGALLREEVAV 152
Query: 608 NGVVESMK-VVTADNSERVXXXXXXXXXKNGRXKVTTVHKANIMK 739
+ +V++ K V K+GR +VT KAN+++
Sbjct: 153 DTLVQTRKGVERIVRFAFELARTRNGSPKDGRRRVTCCDKANVLR 197
>UniRef50_Q6L2P9 Cluster: Isocitrate dehydrogenase [NADP]; n=2;
Thermoplasmatales|Rep: Isocitrate dehydrogenase [NADP] -
Picrophilus torridus
Length = 392
Score = 41.1 bits (92), Expect = 0.031
Identities = 52/209 (24%), Positives = 86/209 (41%), Gaps = 30/209 (14%)
Frame = +2
Query: 245 GGGIGPECMGYVRDIFKYIGA----PIDFEVV---DIDPTMDNDDDVQYAITTIKRNGVG 403
G GIGPE M R + A I ++ + D + D + +I I V
Sbjct: 24 GDGIGPEIMDATRKVVDAATAMEKKSIAWKEILLGDRAEELKGDRFPEESIKAINDYRVL 83
Query: 404 LKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKD---IDVVIIRQNT- 571
LK + T + S NV +R LD+YA I K PG+ + K+ +++ I R+NT
Sbjct: 84 LKAPLNTPVGKGF-KSINVRIRMLLDLYANIRPVKFMPGLESPLKNPEKVNLTIFRENTD 142
Query: 572 ------EGEYAMLEHESVNGVVE-------------SMKVVTADNSERVXXXXXXXXXKN 694
E Y E + + ++ +K ++ ++R+ N
Sbjct: 143 DLYLGYEWSYDTDEAKRIRKFLKDEFNIDISDDSGIGIKPMSRYKTQRITRLAVKYAMDN 202
Query: 695 GRXKVTTVHKANIMKLSDGLFLETSXRLA 781
K+T +HK N+MK ++G F E + A
Sbjct: 203 NLKKITIMHKGNVMKYTEGAFREWAYETA 231
>UniRef50_Q8FPV5 Cluster: 3-isopropylmalate dehydrogenase; n=50;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Corynebacterium efficiens
Length = 340
Score = 41.1 bits (92), Expect = 0.031
Identities = 48/198 (24%), Positives = 84/198 (42%), Gaps = 13/198 (6%)
Frame = +2
Query: 230 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPT--MDNDDDV-QYAITTIKRNGV 400
+ ++ G GIGPE + + + A I+ +D+ + N + + + ++ +
Sbjct: 3 LAVIGGDGIGPEVTDEALKVLRALRADIETTDLDLGARRYLRNGELLTDEDLALLREHDA 62
Query: 401 GLKGNIETK-SEAAYVTSRNVAL--RNELDMYAYILNCKSYPGVATRHK---DIDVVIIR 562
L G I S V R + L R LD + + K Y GV + K +ID V++R
Sbjct: 63 ILLGAIGAPGSVPPGVLERGLLLKLRFALDHHVNLRPSKLYEGVESPLKNPGEIDFVVVR 122
Query: 563 QNTEGEY----AMLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKAN 730
+ TEG Y + + + V T +ERV ++ R +T VHK N
Sbjct: 123 EGTEGAYTGNGGAIRVGTPHETANETSVNTRYGAERV-IRYAFELAQSRRRHLTLVHKTN 181
Query: 731 IMKLSDGLFLETSXRLAK 784
++ GL+ T +A+
Sbjct: 182 VLVHGGGLWQRTVDEVAR 199
>UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2;
Bacillaceae|Rep: Tartrate dehydrogenase - Bacillus sp.
B14905
Length = 362
Score = 39.9 bits (89), Expect = 0.071
Identities = 25/96 (26%), Positives = 43/96 (44%), Gaps = 7/96 (7%)
Frame = +2
Query: 464 LRNELDMYAYILNCKSYPGVATR---HKDIDVVIIRQNTEGEYA----MLEHESVNGVVE 622
+R Y KS PG+++ DID VI R+N EGEY+ L + +
Sbjct: 94 IRKNFQQYVNFRPIKSLPGISSPLAGGNDIDFVIFRENAEGEYSDSGGRLYQQQPQEMTI 153
Query: 623 SMKVVTADNSERVXXXXXXXXXKNGRXKVTTVHKAN 730
++T E++ ++G+ K+T+ K+N
Sbjct: 154 QNTIMTRIGIEKIVRAACEYAQQHGKTKLTSATKSN 189
>UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular
organisms|Rep: Tartrate dehydrogenase - Burkholderia
mallei (Pseudomonas mallei)
Length = 361
Score = 39.5 bits (88), Expect = 0.093
Identities = 45/194 (23%), Positives = 79/194 (40%), Gaps = 20/194 (10%)
Frame = +2
Query: 224 HAVTMLPGGGIG----PECMGYVRDIFKYIGA-----PIDFEVVDIDPTMDN--DDDVQY 370
+ + ++PG GIG PE + + + + G PI++ D DD +
Sbjct: 6 YRIAVIPGDGIGVEVMPEGLRALDAVSRRFGLRFAYEPIEWASCDYYAKHGQMMPDDWKT 65
Query: 371 AITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGV-----ATRH 535
++ + G G ET + + + R E D Y + + + GV +
Sbjct: 66 QLSGMDALLFGAVGWPETVPDHISLWGSLIKFRREFDQYVNLRPARLFDGVPCPLAGRKA 125
Query: 536 KDIDVVIIRQNTEGEYAMLEHESVNGV----VESMKVVTADNSERVXXXXXXXXXKNGRX 703
DID +I+R+NTEGEY+ + G V V T +ERV + +
Sbjct: 126 GDIDFMIVRENTEGEYSAVGGTMFEGTEREFVVQQAVFTRHGTERVLKFAFELAQRRAK- 184
Query: 704 KVTTVHKANIMKLS 745
++T K+N + +S
Sbjct: 185 RLTVATKSNGIAIS 198
>UniRef50_A6G3V7 Cluster: Probable 3-isopropylmalate dehydrogenase;
n=1; Plesiocystis pacifica SIR-1|Rep: Probable
3-isopropylmalate dehydrogenase - Plesiocystis pacifica
SIR-1
Length = 368
Score = 38.7 bits (86), Expect = 0.16
Identities = 40/133 (30%), Positives = 57/133 (42%), Gaps = 21/133 (15%)
Frame = +2
Query: 401 GLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATR----HKDI------DV 550
G G + K S + R L++YA + K YPGV R HK I D+
Sbjct: 65 GTGGPVLMKDNKMAGFSPVIGNRMRLNLYANVRPIKLYPGVQHRIHGGHKQIWEAGKVDM 124
Query: 551 VIIRQNTEGEYAMLEHESVNG----VVESMKVVTADNSERVXXXX-------XXXXXKNG 697
VIIR+NTEG YA + G V +V+T E+V K+G
Sbjct: 125 VIIRENTEGLYAPTGGKLAPGGKADVAIDTRVITRRACEQVIRHAFELCKRRNKGAPKDG 184
Query: 698 RXKVTTVHKANIM 736
+ +VT + K N++
Sbjct: 185 KLRVTAIIKDNVL 197
>UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Saccharopolyspora erythraea NRRL 2338|Rep:
3-isopropylmalate dehydrogenase - Saccharopolyspora
erythraea (strain NRRL 23338)
Length = 407
Score = 37.5 bits (83), Expect = 0.38
Identities = 52/205 (25%), Positives = 82/205 (40%), Gaps = 21/205 (10%)
Frame = +2
Query: 230 VTMLPGGGIGPECMGYVRDIFKYI-GAPIDFEVVDIDPTMDNDDDVQYAIT--TIKR--- 391
+ ++PG GIGPE + ++ + G ++ D D A++ T++R
Sbjct: 9 IAVIPGDGIGPELVRSAVEVLRAAAGRDVELRFTSEDAGADAFRRTGSAMSAATLERIRT 68
Query: 392 --NGVGLKGNIETKS----EAAYVTSRNVALRNELDMYAYILNCKSYPGVAT--RHKDID 547
+GV LKG + + LR LD YA + PGV R +D
Sbjct: 69 RYHGV-LKGPVGLPGVRHPDGTEAGLLGGVLRGGLDTYANVRPIALLPGVDAPLRGTAVD 127
Query: 548 VVIIRQNTEGEYAMLEHESVNG-VVESMKVVTADNSERVXXXXXXXXXK------NGRXK 706
VI+R+NTEG Y N ++T ERV + +G +
Sbjct: 128 YVIVRENTEGLYLSRGRGVGNDRACADQLLMTRHGVERVVVHAFELATRRTGAPADGVRR 187
Query: 707 VTTVHKANIMKLSDGLFLETSXRLA 781
VT V K+N+++ S F E +A
Sbjct: 188 VTCVDKSNVLR-SFAFFREVFDEVA 211
>UniRef50_P56471 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 90
Score = 36.3 bits (80), Expect = 0.87
Identities = 18/37 (48%), Positives = 20/37 (54%)
Frame = +2
Query: 215 GGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEV 325
GG VT++PG GIGPE V IF API V
Sbjct: 2 GGVKTVTLIPGDGIGPEISAAVMKIFDAAKAPIQANV 38
>UniRef50_Q89RJ1 Cluster: 3-isopropylmalate dehydrogenase; n=7;
Alphaproteobacteria|Rep: 3-isopropylmalate dehydrogenase
- Bradyrhizobium japonicum
Length = 368
Score = 35.9 bits (79), Expect = 1.2
Identities = 31/104 (29%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Frame = +2
Query: 458 VALRNELDMYAYILNCKSYPGVATR-----HKDIDVVIIRQNTEGEYAMLEHESV-NGVV 619
+ LR D+YA + + PGV + + ID+V+IR++TEG +A + V +
Sbjct: 104 IELRFIFDLYAGVRPARLIPGVPSPIVGADTRGIDLVVIRESTEGLFASMGKGVVTHEDA 163
Query: 620 ESMKVVTADNSERV-XXXXXXXXXKNGRXK---VTTVHKANIMK 739
V+T SER+ + R K +T V KAN+ K
Sbjct: 164 RETMVITRRTSERLFEFSFRLAARRKARGKPGMLTCVDKANVFK 207
>UniRef50_A7GLU7 Cluster: Tartrate dehydrogenase; n=3; Bacteria|Rep:
Tartrate dehydrogenase - Bacillus cereus subsp.
cytotoxis NVH 391-98
Length = 364
Score = 35.5 bits (78), Expect = 1.5
Identities = 23/76 (30%), Positives = 37/76 (48%), Gaps = 4/76 (5%)
Frame = +2
Query: 530 RHKDIDVVIIRQNTEGEYA----MLEHESVNGVVESMKVVTADNSERVXXXXXXXXXKNG 697
+ +DID++ IR+N+EGEYA L + VV V + +ER+ K
Sbjct: 121 KREDIDMLFIRENSEGEYAGAGDWLYKGKEHEVVLQNSVFSRKGTERIIRYAFEIARKE- 179
Query: 698 RXKVTTVHKANIMKLS 745
R +T++ K N + S
Sbjct: 180 RKSLTSISKGNALNYS 195
>UniRef50_Q08KN2 Cluster: FIg-Hepta; n=3; Takifugu rubripes|Rep:
FIg-Hepta - Fugu rubripes (Japanese pufferfish)
(Takifugu rubripes)
Length = 1678
Score = 35.1 bits (77), Expect = 2.0
Identities = 28/131 (21%), Positives = 54/131 (41%)
Frame = -1
Query: 669 NXATLSELSAVTTFIDSTTPFTDSCSNIAYSPSVFCLIITTSMSLCLVATPG*DLQFSM* 490
N + ++L+ T + STTPFT+S + + F ++ T+ +L + ++ +
Sbjct: 517 NSTSTTDLNTTTPPVSSTTPFTNSTPPTDLNNTTFTTVVVTNSTLTSATSLNTTIKANRT 576
Query: 489 AYMSSSFLRATLRDVT*AASLLVSMLPFSPTPFLLMVVIAYWTSSSLSIVGSMSTTSKSI 310
+S+ AT T A + + S T T+S+ + + +TTS +
Sbjct: 577 TATTSATTAATTSATTEATTSATTSATTSATTSATTSATTEETTSATTSATTSATTSATT 636
Query: 309 GAPMYLNMSRT 277
A S T
Sbjct: 637 SATTEATTSAT 647
>UniRef50_A6PN62 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Victivallis vadensis ATCC BAA-548|Rep: 3-isopropylmalate
dehydrogenase - Victivallis vadensis ATCC BAA-548
Length = 369
Score = 35.1 bits (77), Expect = 2.0
Identities = 35/137 (25%), Positives = 54/137 (39%), Gaps = 17/137 (12%)
Frame = +2
Query: 224 HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAIT-------- 379
+ + +LPG G GPE + + G F + N Y T
Sbjct: 5 YKIAVLPGDGTGPEVIAEAVKVLDAAGRKFGFTT---EKEYYNWGGAHYLATGETLPADA 61
Query: 380 --TIKRNGVGLKGNIETKSEAAYVTSRNVAL--RNELDMYAYILNCKSYPGVAT-----R 532
+ R+ L G I V + + L R +LD Y + K +PGV T +
Sbjct: 62 KEQLARHDAVLLGAIGHPDVKPGVLEKGILLKLRFDLDQYINLRPVKLFPGVETPLANKK 121
Query: 533 HKDIDVVIIRQNTEGEY 583
+DID V++R+N+ G Y
Sbjct: 122 PEDIDYVVVRENSGGVY 138
>UniRef50_A4C445 Cluster: VCBS; n=1; Pseudoalteromonas tunicata
D2|Rep: VCBS - Pseudoalteromonas tunicata D2
Length = 1600
Score = 35.1 bits (77), Expect = 2.0
Identities = 19/66 (28%), Positives = 30/66 (45%), Gaps = 2/66 (3%)
Frame = +2
Query: 140 TLSDFDVQHKTPVIRKQKLI--PKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPI 313
T+++ QH T ++ +L+ P+A Y G +T G G GYV K + A I
Sbjct: 1330 TVTNISAQHGTVTLQNGQLVYTPQASYSGADEITYTVSDGKGGSAQGYVEVTIKPVNATI 1389
Query: 314 DFEVVD 331
V+
Sbjct: 1390 SLIAVN 1395
>UniRef50_A5UWW1 Cluster: Agmatine deiminase; n=9; cellular
organisms|Rep: Agmatine deiminase - Roseiflexus sp. RS-1
Length = 348
Score = 34.7 bits (76), Expect = 2.7
Identities = 18/77 (23%), Positives = 40/77 (51%), Gaps = 1/77 (1%)
Frame = +2
Query: 164 HKTPVIRKQKLIPK-AQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDP 340
++ P + ++++ + Y G + L G +G + G++ D+ +++ VV+ DP
Sbjct: 180 NRNPHLTREQIEQRLCDYLGVSNILWLGDGIVGDDTDGHIDDLARFVAPDTVVTVVESDP 239
Query: 341 TMDNDDDVQYAITTIKR 391
T +N D +Q + +KR
Sbjct: 240 TDENYDALQENLRRLKR 256
>UniRef50_A0E5I0 Cluster: Chromosome undetermined scaffold_8, whole
genome shotgun sequence; n=1; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_8,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 293
Score = 34.7 bits (76), Expect = 2.7
Identities = 29/104 (27%), Positives = 48/104 (46%), Gaps = 8/104 (7%)
Frame = +2
Query: 344 MDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRN------ELDMYAYILNC 505
M N D Y I ++ +GL +IE S +++ N+ L+N + +L+C
Sbjct: 1 MQNCDLNSYQIGLSRKQQLGLYSDIEYSSSRYSLSTNNLNLKNLQNLKNRISQLQSVLSC 60
Query: 506 KSYPGVATRHKDIDVVIIRQNTEGEYAMLEHE--SVNGVVESMK 631
K G TR K +D N + Y++ EH+ +N +SMK
Sbjct: 61 KYRKGSLTRSK-LDDSTNLTNDKSTYSLQEHKYNFINFPQQSMK 103
>UniRef50_A3Y262 Cluster: Phosphorelay protein; n=4;
Vibrionales|Rep: Phosphorelay protein - Vibrio sp.
MED222
Length = 114
Score = 34.3 bits (75), Expect = 3.5
Identities = 12/27 (44%), Positives = 21/27 (77%)
Frame = -3
Query: 325 HFEVNRSTDVFEYVANVSHALRTDTAS 245
H E+N+ +D +Y+A++SHAL++ AS
Sbjct: 39 HLELNKESDTSKYLADISHALKSSAAS 65
>UniRef50_P35484 Cluster: Dihydrolipoyl dehydrogenase; n=3;
Acholeplasmataceae|Rep: Dihydrolipoyl dehydrogenase -
Acholeplasma laidlawii
Length = 336
Score = 34.3 bits (75), Expect = 3.5
Identities = 31/105 (29%), Positives = 50/105 (47%), Gaps = 2/105 (1%)
Frame = +2
Query: 119 SSKAAPATLSDFDVQHKTPVIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKY 298
SS P + K V+ ++L+ Y ++ ++ GG IG E +F
Sbjct: 141 SSAVVPPIPGVKEAYEKGIVVTSRELLNVKNYP--KSIVIVGGGVIGVE----FATVFNS 194
Query: 299 IGAPIDF-EVVD-IDPTMDNDDDVQYAITTIKRNGVGLKGNIETK 427
G+ + E++D I PTMD+D V YA T+KR+G+ + E K
Sbjct: 195 FGSKVTIIEMMDGILPTMDDDIRVAYA-KTLKRDGIEILTKAEVK 238
>UniRef50_Q13FQ0 Cluster: Tartrate dehydrogenase; n=3;
Proteobacteria|Rep: Tartrate dehydrogenase -
Burkholderia xenovorans (strain LB400)
Length = 364
Score = 33.5 bits (73), Expect = 6.1
Identities = 26/111 (23%), Positives = 49/111 (44%), Gaps = 9/111 (8%)
Frame = +2
Query: 479 DMYAYILNCKSYPGVATRHK-----DIDVVIIRQNTEGEYAMLEHESVNG----VVESMK 631
D YA + + PG+ K D++ VI+R+N+EGEY+ + G +
Sbjct: 99 DQYANVRPTRILPGIDGPLKRCKPGDLNWVIVRENSEGEYSGVGGRVHQGHPIEAATDVS 158
Query: 632 VVTADNSERVXXXXXXXXXKNGRXKVTTVHKANIMKLSDGLFLETSXRLAK 784
++T ER+ R +T + K+N + + L+ E + ++K
Sbjct: 159 ILTRAGVERIMRFAFRLAQSRPRKLLTVITKSNAQRHAMVLWDEIALEISK 209
>UniRef50_A3W960 Cluster: SCO1/SenC family protein; n=2;
Roseovarius|Rep: SCO1/SenC family protein - Roseovarius
sp. 217
Length = 217
Score = 33.5 bits (73), Expect = 6.1
Identities = 18/56 (32%), Positives = 29/56 (51%)
Frame = +2
Query: 269 MGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEA 436
M ++ + G + ++ IDP +D + + A+T I + VGL GN E SEA
Sbjct: 90 MADAAEVLERRGISVSPVLITIDPVLDTVETMGPALTKISADLVGLTGNREALSEA 145
>UniRef50_Q8IC48 Cluster: Putative uncharacterized protein
PF07_0004; n=1; Plasmodium falciparum 3D7|Rep: Putative
uncharacterized protein PF07_0004 - Plasmodium
falciparum (isolate 3D7)
Length = 964
Score = 33.5 bits (73), Expect = 6.1
Identities = 22/81 (27%), Positives = 39/81 (48%), Gaps = 2/81 (2%)
Frame = +2
Query: 311 IDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNE-LDMY 487
I++E+++++ D+D+DV+Y + I+ + +E K E N L+ E L+
Sbjct: 172 IEYEIIEVEVDDDDDEDVEYEVIEIEVDDDEEVELLEDKEEKIEEVKENKQLKVESLEKK 231
Query: 488 AY-ILNCKSYPGVATRHKDID 547
I YP V K+ID
Sbjct: 232 PLEIKTTPKYPFVTDEQKEID 252
>UniRef50_A0DX95 Cluster: Chromosome undetermined scaffold_68, whole
genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_68,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 818
Score = 33.5 bits (73), Expect = 6.1
Identities = 11/40 (27%), Positives = 25/40 (62%)
Frame = +1
Query: 655 EGGXVRLRIRQXKRQEXGNNGSQSQHHEVIRWLILGDVTS 774
E +R +++ Q G+ GS + +H+V++ +++GD +S
Sbjct: 343 ESSELRNEVKKLNNQRAGSRGSSNDYHDVLKLMLVGDESS 382
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 797,343,724
Number of Sequences: 1657284
Number of extensions: 16521128
Number of successful extensions: 46773
Number of sequences better than 10.0: 93
Number of HSP's better than 10.0 without gapping: 44685
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 46678
length of database: 575,637,011
effective HSP length: 99
effective length of database: 411,565,895
effective search space used: 66673674990
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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