Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fcaL-P05_F_I15
(853 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]... 386 e-106
UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 361 2e-98
UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalyti... 298 1e-79
UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3; Bacteria... 273 4e-72
UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 270 2e-71
UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella ve... 258 1e-67
UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulato... 251 1e-65
UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulato... 245 1e-63
UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 241 2e-62
UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate dehydrog... 240 3e-62
UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2; Bacteria... 233 3e-60
UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 233 5e-60
UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 231 2e-59
UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 228 1e-58
UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;... 223 6e-57
UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8; Bilateri... 220 4e-56
UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p... 210 3e-53
UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 196 8e-49
UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep: C... 195 1e-48
UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68; Bacteri... 193 4e-48
UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1... 157 6e-47
UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10; ... 188 2e-46
UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate dehydrog... 176 7e-43
UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependen... 175 9e-43
UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3; Ricketts... 175 2e-42
UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6; T... 174 2e-42
UniRef50_Q2UP37 Cluster: Isocitrate/isopropylmalate dehydrogenas... 167 2e-40
UniRef50_Q4UKR1 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 165 1e-39
UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6; E... 161 2e-38
UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8; E... 158 2e-37
UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD] s... 151 2e-35
UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;... 142 1e-32
UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenas... 140 3e-32
UniRef50_Q9RTT2 Cluster: Isocitrate dehydrogenase, putative; n=2... 137 3e-31
UniRef50_Q58991 Cluster: Threo-isocitrate dehydrogenase [NAD]; n... 136 9e-31
UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9; B... 132 1e-29
UniRef50_Q0W1Q6 Cluster: 2-isopropylmalate dehydrogenase; n=5; E... 131 2e-29
UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2; Alp... 130 4e-29
UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 129 1e-28
UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5; C... 128 1e-28
UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase, mitochond... 126 9e-28
UniRef50_Q8FPV5 Cluster: 3-isopropylmalate dehydrogenase; n=50; ... 125 1e-27
UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]... 125 1e-27
UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3; P... 124 4e-27
UniRef50_A1SM34 Cluster: 3-isopropylmalate dehydrogenase; n=1; N... 123 5e-27
UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;... 120 4e-26
UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5; T... 119 1e-25
UniRef50_Q8XSY8 Cluster: Probable 3-isopropylmalate dehydrogenas... 118 2e-25
UniRef50_Q8U299 Cluster: 3-isopropylmalate dehydrogenase 2; n=3;... 116 8e-25
UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependen... 116 8e-25
UniRef50_Q0X0C1 Cluster: Putative dehydrogenase; n=1; Streptomyc... 115 2e-24
UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1; Ent... 114 3e-24
UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular ... 113 4e-24
UniRef50_O29610 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 113 5e-24
UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 112 9e-24
UniRef50_Q6L2P9 Cluster: Isocitrate dehydrogenase [NADP]; n=2; T... 112 1e-23
UniRef50_Q5HNL1 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 111 2e-23
UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for ... 110 5e-23
UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421, ... 109 7e-23
UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate... 109 9e-23
UniRef50_A7GLU7 Cluster: Tartrate dehydrogenase; n=3; Bacteria|R... 107 3e-22
UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase; n... 106 6e-22
UniRef50_Q44471 Cluster: Probable tartrate dehydrogenase/decarbo... 106 6e-22
UniRef50_Q8DTG3 Cluster: 3-isopropylmalate dehydrogenase; n=41; ... 105 1e-21
UniRef50_A0P1S6 Cluster: 3-isopropylmalate dehydrogenase; n=2; R... 105 2e-21
UniRef50_Q13FQ0 Cluster: Tartrate dehydrogenase; n=3; Proteobact... 103 4e-21
UniRef50_O67480 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 103 6e-21
UniRef50_Q0W5L4 Cluster: 3-isopropylmalate dehydrogenase; n=10; ... 103 8e-21
UniRef50_Q8E9N3 Cluster: 3-isopropylmalate dehydrogenase; n=148;... 103 8e-21
UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1; S... 102 1e-20
UniRef50_Q03UM1 Cluster: 3-isopropylmalate dehydrogenase; n=2; L... 101 3e-20
UniRef50_Q1IZK2 Cluster: 3-isopropylmalate dehydrogenase; n=3; B... 100 9e-20
UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: Leu... 99 1e-19
UniRef50_Q7UTP0 Cluster: 3-isopropylmalate dehydrogenase; n=2; B... 97 4e-19
UniRef50_Q8A6M0 Cluster: 3-isopropylmalate dehydrogenase; n=42; ... 97 5e-19
UniRef50_Q81T67 Cluster: 3-isopropylmalate dehydrogenase; n=9; B... 97 7e-19
UniRef50_Q89RJ1 Cluster: 3-isopropylmalate dehydrogenase; n=7; A... 96 1e-18
UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;... 95 2e-18
UniRef50_Q48806 Cluster: Protein dlpA; n=4; Legionella pneumophi... 95 3e-18
UniRef50_Q9FMT1 Cluster: 3-isopropylmalate dehydrogenase 3, chlo... 93 1e-17
UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 92 1e-17
UniRef50_Q9CKK6 Cluster: Idp; n=2; Pasteurellaceae|Rep: Idp - Pa... 91 3e-17
UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2; Bacillacea... 91 3e-17
UniRef50_Q7VH33 Cluster: 3-isopropylmalate dehydrogenase; n=11; ... 89 1e-16
UniRef50_A6GJ83 Cluster: Isocitrate dehydrogenase; n=1; Plesiocy... 88 3e-16
UniRef50_Q2JTN8 Cluster: 3-isopropylmalate dehydrogenase; n=72; ... 87 5e-16
UniRef50_Q1IMD5 Cluster: 3-isopropylmalate dehydrogenase; n=1; A... 85 2e-15
UniRef50_A7T3D9 Cluster: Predicted protein; n=1; Nematostella ve... 85 2e-15
UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma... 85 2e-15
UniRef50_Q8YCX4 Cluster: 3-isopropylmalate dehydrogenase; n=126;... 85 2e-15
UniRef50_Q67LW7 Cluster: Tartrate dehydrogenase; n=2; Bacteria|R... 85 3e-15
UniRef50_Q7UIE1 Cluster: 3-isopropylmalate dehydrogenase; n=4; B... 84 4e-15
UniRef50_Q05FQ8 Cluster: 3-isopropylmalate dehydrogenase; n=1; C... 83 9e-15
UniRef50_A0ZF75 Cluster: 3-isopropylmalate dehydrogenase; n=2; N... 83 1e-14
UniRef50_A5URE6 Cluster: Isocitrate dehydrogenase, NADP-dependen... 82 2e-14
UniRef50_A6PN62 Cluster: 3-isopropylmalate dehydrogenase; n=1; V... 81 5e-14
UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 80 8e-14
UniRef50_Q89XA0 Cluster: 3-isopropylmalate dehydrogenase 1; n=3;... 79 2e-13
UniRef50_A0Q405 Cluster: 3-isopropylmalate dehydrogenase; n=5; F... 78 3e-13
UniRef50_Q12545 Cluster: 3-isopropylmalate dehydrogenase; n=2; H... 78 3e-13
UniRef50_Q3ZXI7 Cluster: 3-isopropylmalate dehydrogenase; n=66; ... 76 1e-12
UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9; Eut... 76 1e-12
UniRef50_A1SWV5 Cluster: 3-isopropylmalate dehydrogenase; n=1; P... 75 2e-12
UniRef50_A6G3V7 Cluster: Probable 3-isopropylmalate dehydrogenas... 75 3e-12
UniRef50_P04173 Cluster: 3-isopropylmalate dehydrogenase; n=41; ... 74 5e-12
UniRef50_Q6L0K7 Cluster: 3-isopropylmalate dehydrogenase; n=2; T... 73 9e-12
UniRef50_A1WV93 Cluster: 3-isopropylmalate dehydrogenase; n=7; G... 69 2e-10
UniRef50_Q6B458 Cluster: 3-isopropylmalate dehydrogenase; n=30; ... 66 1e-09
UniRef50_A5DIP7 Cluster: Putative uncharacterized protein; n=1; ... 65 2e-09
UniRef50_O59930 Cluster: 3-isopropylmalate dehydrogenase; n=3; D... 64 3e-09
UniRef50_UPI00003C8595 Cluster: hypothetical protein Faci_030007... 61 4e-08
UniRef50_A5DIP6 Cluster: Putative uncharacterized protein; n=1; ... 60 5e-08
UniRef50_P34738 Cluster: 3-isopropylmalate dehydrogenase; n=5; S... 58 2e-07
UniRef50_A0FP11 Cluster: Isocitrate/isopropylmalate dehydrogenas... 58 3e-07
UniRef50_Q4V533 Cluster: IP13250p; n=4; Drosophila melanogaster|... 58 3e-07
UniRef50_Q18WQ3 Cluster: Isocitrate/isopropylmalate dehydrogenas... 58 4e-07
UniRef50_P56471 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 54 5e-06
UniRef50_Q0A635 Cluster: Isocitrate/isopropylmalate dehydrogenas... 53 8e-06
UniRef50_Q300E7 Cluster: Isocitrate/isopropylmalate dehydrogenas... 53 1e-05
UniRef50_Q67N12 Cluster: 3-isopropylmalate dehydrogenase; n=5; B... 52 1e-05
UniRef50_Q4P2R4 Cluster: Putative uncharacterized protein; n=1; ... 52 1e-05
UniRef50_Q12592 Cluster: 3-isopropylmalate dehydrogenase; n=3; A... 51 3e-05
UniRef50_Q2Q9C5 Cluster: Isocitrate dehydrogenase 3 gamma; n=8; ... 48 3e-04
UniRef50_Q08522 Cluster: Putative uncharacterized protein YOR135... 47 7e-04
UniRef50_Q5IWY1 Cluster: Plastid 3-isopropylmalate dehydrogenase... 43 0.011
UniRef50_Q5A9E0 Cluster: Putative uncharacterized protein; n=1; ... 42 0.015
UniRef50_P41566 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 39 0.14
UniRef50_A2E7S3 Cluster: Putative uncharacterized protein; n=1; ... 36 0.98
UniRef50_Q8WWQ4 Cluster: Mucin 5; n=5; Catarrhini|Rep: Mucin 5 -... 36 0.98
UniRef50_O59395 Cluster: Putative uncharacterized protein PH1723... 36 0.98
UniRef50_Q0P4K8 Cluster: NFATC2-interacting protein; n=1; Xenopu... 36 0.98
UniRef50_Q2Q0B6 Cluster: Putative 3-isopropylmalate dehydrogenas... 36 1.7
UniRef50_Q6AGK4 Cluster: Putative uncharacterized protein; n=1; ... 35 2.3
UniRef50_Q6JAD6 Cluster: Putative uncharacterized protein; n=1; ... 35 2.3
UniRef50_A5FB87 Cluster: Von Willebrand factor, type A precursor... 34 4.0
UniRef50_A3DDD4 Cluster: Phage integrase; n=5; Clostridia|Rep: P... 34 4.0
UniRef50_A7PLS7 Cluster: Chromosome chr14 scaffold_21, whole gen... 34 4.0
UniRef50_A2TU03 Cluster: Ribonuclease HII; n=1; Dokdonia donghae... 34 5.2
UniRef50_Q7RB56 Cluster: Fulmal1; n=2; Plasmodium (Vinckeia)|Rep... 34 5.2
UniRef50_A7SWW3 Cluster: Predicted protein; n=1; Nematostella ve... 34 5.2
UniRef50_Q2UNH1 Cluster: Predicted protein; n=2; Trichocomaceae|... 34 5.2
UniRef50_A5DW24 Cluster: Putative uncharacterized protein; n=2; ... 34 5.2
UniRef50_Q9RA19 Cluster: ORF10; n=1; Moritella marina|Rep: ORF10... 33 6.9
UniRef50_Q1QFN8 Cluster: Glycosidase, PH1107-related; n=2; Brady... 33 6.9
UniRef50_A7R2H9 Cluster: Chromosome undetermined scaffold_430, w... 33 6.9
UniRef50_Q2VF40 Cluster: Isocitrate dehydrogenase 3 gamma subuni... 33 6.9
UniRef50_UPI0000D5678D Cluster: PREDICTED: similar to CG33087-PC... 33 9.1
UniRef50_Q8D4B1 Cluster: Putative uncharacterized protein; n=2; ... 33 9.1
UniRef50_Q5NXI3 Cluster: Putative uncharacterized protein; n=1; ... 33 9.1
UniRef50_Q1D919 Cluster: Putative uncharacterized protein; n=1; ... 33 9.1
UniRef50_A6DSS2 Cluster: NOL1/NOP2/sun family putative RNA methy... 33 9.1
>UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH); n=6;
Eukaryota|Rep: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Caenorhabditis elegans
Length = 358
Score = 386 bits (950), Expect = e-106
Identities = 187/260 (71%), Positives = 216/260 (83%), Gaps = 1/260 (0%)
Frame = +2
Query: 77 MAARIIRKIVPATRAGAAQYSTG-VRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEV 253
M + I+K +T + +YS+G VR+VTLIPG GIGPEI+ +VQKIFEAA PI W+ V
Sbjct: 1 MLGKCIKK-ASSTVGQSIRYSSGDVRRVTLIPGDGIGPEISASVQKIFEAADAPIAWDPV 59
Query: 254 DVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRP 433
DVT V+G DG F IP + I+ ++ANK+GLKGPL TP+GKG+RSLNLA+RKEF LYANVRP
Sbjct: 60 DVTPVKGRDGVFRIPSRCIELMHANKVGLKGPLETPIGKGHRSLNLAVRKEFSLYANVRP 119
Query: 434 CKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQF 613
C+SLEG KTLYDNVDVVTIRENTEGEYSGIEHEIV GVVQSIKLITE AS VA FAF++
Sbjct: 120 CRSLEGHKTLYDNVDVVTIRENTEGEYSGIEHEIVPGVVQSIKLITETASRNVASFAFEY 179
Query: 614 ARENKRKKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKF 793
AR+N RK VTAVHKANIMR S GLFL CRE A YPDIKF+ YL TVCLNMVQDPS++
Sbjct: 180 ARQNGRKVVTAVHKANIMRQSDGLFLSICREQAALYPDIKFKEAYLDTVCLNMVQDPSQY 239
Query: 794 DVLVMPNLYGDIMSDMCSGL 853
DVLVMPNLYGDI+SD+C+GL
Sbjct: 240 DVLVMPNLYGDILSDLCAGL 259
>UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=62;
Eukaryota|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Homo sapiens
(Human)
Length = 366
Score = 361 bits (887), Expect = 2e-98
Identities = 170/240 (70%), Positives = 201/240 (83%)
Frame = +2
Query: 134 YSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAID 313
++ GV+ VTLIPG GIGPEI+ AV KIF+AAK PI+WEE +VTA++GP GK+ IP +A +
Sbjct: 27 FTGGVQTVTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPSEAKE 86
Query: 314 SVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIR 493
S++ NK+GLKGPL TP+ G+ S+NL LRK FDLYANVRPC S+EG KT Y +V++VTIR
Sbjct: 87 SMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIR 146
Query: 494 ENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRM 673
ENTEGEYSGIEH IVDGVVQSIKLITE AS R+AEFAF++AR N R VTAVHKANIMRM
Sbjct: 147 ENTEGEYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTAVHKANIMRM 206
Query: 674 SXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGL 853
S GLFL+ CRE+A DIKF YL TVCLNMVQDPS+FDVLVMPNLYGDI+SD+C+GL
Sbjct: 207 SDGLFLQKCREVAESCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGL 266
>UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalytic
subunit 6, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 6) (NAD(+)-specific ICDH 6);
n=10; cellular organisms|Rep: Isocitrate dehydrogenase
[NAD] catalytic subunit 6, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 6) (NAD(+)-specific
ICDH 6) - Arabidopsis thaliana (Mouse-ear cress)
Length = 374
Score = 298 bits (732), Expect = 1e-79
Identities = 137/234 (58%), Positives = 181/234 (77%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 331
K TL PG GIGPEI +V+++F AA V I+W+E V P + + SV NK
Sbjct: 45 KATLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFVGTEVDPRTNSFLTWDNLQSVLKNK 104
Query: 332 IGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGE 511
+GLKGP+ TP+GKG+RSLNL LRKE +LYANVRPC SL G KT YD+VD++TIRENTEGE
Sbjct: 105 VGLKGPMATPIGKGHRSLNLTLRKELNLYANVRPCYSLPGYKTRYDDVDLITIRENTEGE 164
Query: 512 YSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSXGLFL 691
YSG+EH++V GVV+S+K+IT +AS RVAE+AF +A+ + RKKV+A+HKANIM+ + GLFL
Sbjct: 165 YSGLEHQVVKGVVESLKIITRKASMRVAEYAFLYAKTHGRKKVSAIHKANIMQKTDGLFL 224
Query: 692 RCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGL 853
+CC E+A KYP+I +E + C+ +V++P+ FDVLVMPNLYGDI+SD+C+GL
Sbjct: 225 QCCDEVAAKYPEIYYEKVVIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGL 278
>UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3;
Bacteria|Rep: Isocitrate dehydrogenase - Acidobacteria
bacterium (strain Ellin345)
Length = 348
Score = 273 bits (669), Expect = 4e-72
Identities = 120/234 (51%), Positives = 173/234 (73%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 331
K+TLIPG GIGPE+T A ++ EA + EWE A K IP++ +S+ +
Sbjct: 4 KITLIPGDGIGPEVTSAAVRVLEATGLKFEWESFAAGAEAYEKYKEYIPKELNESIERTR 63
Query: 332 IGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGE 511
IGLKGP+ TP+G G+ S+N+ LRK F+LYANVRP ++L G+ T Y VD+V +RENTEG
Sbjct: 64 IGLKGPVTTPIGGGFSSINVELRKRFELYANVRPIRNLPGVHTRYPGVDLVVVRENTEGL 123
Query: 512 YSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSXGLFL 691
YSGIEHE+V GVV+S+K+ITE+ASTR+++FAF +AR+ RKK+ ++HKANIM+MS GLF+
Sbjct: 124 YSGIEHEVVPGVVESLKIITEKASTRISKFAFNYARKMGRKKIHSIHKANIMKMSDGLFI 183
Query: 692 RCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGL 853
RC R ++ +YP+I + + C+ +V +P ++D+L++ NLYGDI+SD+C+GL
Sbjct: 184 RCSRNISKEYPEIIYGEHIVDNTCMQLVMNPYQYDILLLENLYGDIVSDLCAGL 237
>UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=31; cellular
organisms|Rep: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 369
Score = 270 bits (663), Expect = 2e-71
Identities = 135/246 (54%), Positives = 171/246 (69%), Gaps = 2/246 (0%)
Frame = +2
Query: 122 GAAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQ 301
G STG V+ I G GIGPEI+ +V+KIF AA VPIEWE DV+ + +G IP
Sbjct: 28 GKPNPSTGKYTVSFIEGDGIGPEISKSVKKIFSAANVPIEWESCDVSPIF-VNGLTTIPD 86
Query: 302 KAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDV 481
A+ S+ N + LKGPL TP+GKG+RSLNL LRK F L+ANVRP KS+EG KT Y+NVD+
Sbjct: 87 PAVQSITKNLVALKGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGFKTTYENVDL 146
Query: 482 VTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKAN 661
V IRENTEGEYSGIEH + GVVQSIKLIT +AS RV +AF++AR R +V VHK+
Sbjct: 147 VLIRENTEGEYSGIEHIVCPGVVQSIKLITRDASERVIRYAFEYARAIGRPRVIVVHKST 206
Query: 662 IMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFD--VLVMPNLYGDIMS 835
I R++ GLF+ +EL+ +YPD+ E + L +V +PS + V V PNLYGDI+S
Sbjct: 207 IQRLADGLFVNVAKELSKEYPDLTLETELIDNSVLKVVTNPSAYTDAVSVCPNLYGDILS 266
Query: 836 DMCSGL 853
D+ SGL
Sbjct: 267 DLNSGL 272
>UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 394
Score = 258 bits (632), Expect = 1e-67
Identities = 122/246 (49%), Positives = 176/246 (71%), Gaps = 4/246 (1%)
Frame = +2
Query: 128 AQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTA--VRGPDGKFGIPQ 301
A+Y G VTLIPG GIGPE+ VAVQ IF VP+++EE++++ ++ D G
Sbjct: 45 ARYG-GRNTVTLIPGDGIGPEMVVAVQDIFRHIGVPVDFEELNLSGLDIKDEDSYLGAFN 103
Query: 302 KAIDSVNANKIGLKGPLMTPVGK--GYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNV 475
+AI S+ N + +KG + TP+ G+RSLNL LR DL+AN+ CKS+ GI+T ++NV
Sbjct: 104 EAITSIKRNGVAMKGNIFTPLDAIPGFRSLNLELRVHLDLFANIVRCKSIPGIQTRHNNV 163
Query: 476 DVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHK 655
D+V IR+NTEGEYS +EHE V GV++++K+ TEEA ++A++AF FA ++ RKKVTAVHK
Sbjct: 164 DLVIIRQNTEGEYSHLEHENVSGVIENLKVTTEEACMKIAQYAFDFAEKHDRKKVTAVHK 223
Query: 656 ANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMS 835
ANIM+M GLFLRCC E++ YP+I+F + C+ +V P +FDV+V+PNLYG+I+S
Sbjct: 224 ANIMKMGDGLFLRCCEEMSHSYPNIEFNSMIIDNCCMQLVAHPQQFDVMVLPNLYGNIVS 283
Query: 836 DMCSGL 853
++ + L
Sbjct: 284 NIGASL 289
>UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 1) (NAD(+)-specific ICDH 1);
n=7; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 1, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 1) (NAD(+)-specific
ICDH 1) - Arabidopsis thaliana (Mouse-ear cress)
Length = 367
Score = 251 bits (615), Expect = 1e-65
Identities = 119/235 (50%), Positives = 170/235 (72%)
Frame = +2
Query: 149 RKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNAN 328
R VTLIPG GIGP +T AV+++ EA PI +E+ DV G + +P + ++S+ N
Sbjct: 38 RAVTLIPGDGIGPLVTNAVEQVMEAMHAPIFFEKYDV---HGEMSR--VPPEVMESIRKN 92
Query: 329 KIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEG 508
K+ LKG L TPVG G SLN+ LRKE DL+A++ C +L G+ T ++NVD+V IRENTEG
Sbjct: 93 KVCLKGGLKTPVGGGVSSLNVQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEG 152
Query: 509 EYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSXGLF 688
EY+G+EHE+V GVV+S+K+IT+ S R+A++AF++A N RKKVTAVHKANIM+++ GLF
Sbjct: 153 EYAGLEHEVVPGVVESLKVITKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLF 212
Query: 689 LRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGL 853
L CRE+A KYP I + + C+ +V P +FDV+V PNLYG+++++ +G+
Sbjct: 213 LESCREVAKKYPSITYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVANTAAGI 267
>UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 3, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 3) (NAD(+)-specific ICDH 3);
n=23; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 3, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 3) (NAD(+)-specific
ICDH 3) - Arabidopsis thaliana (Mouse-ear cress)
Length = 368
Score = 245 bits (600), Expect = 1e-63
Identities = 117/235 (49%), Positives = 167/235 (71%)
Frame = +2
Query: 149 RKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNAN 328
R VTLIPG GIGP +T AV+++ EA P+ +E +V G K +P++ I+SV N
Sbjct: 39 RTVTLIPGDGIGPLVTGAVEQVMEAMHAPVHFERYEVL---GNMRK--VPEEVIESVKRN 93
Query: 329 KIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEG 508
K+ LKG L TPVG G SLN+ LRKE D++A++ C ++ G+ T ++NVD+V IRENTEG
Sbjct: 94 KVCLKGGLATPVGGGVSSLNMQLRKELDIFASLVNCINVPGLVTRHENVDIVVIRENTEG 153
Query: 509 EYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSXGLF 688
EYSG+EHE+V GVV+S+K+IT+ S R+A +AF++A N RKKVTAVHKANIM+++ GLF
Sbjct: 154 EYSGLEHEVVPGVVESLKVITKFCSERIARYAFEYAYLNNRKKVTAVHKANIMKLADGLF 213
Query: 689 LRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGL 853
L CRE+A Y I + + C+ +V P +FDV+V PNLYG+++++ +G+
Sbjct: 214 LESCREVAKHYSGITYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLIANTAAGI 268
>UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=50;
Deuterostomia|Rep: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 393
Score = 241 bits (589), Expect = 2e-62
Identities = 117/245 (47%), Positives = 172/245 (70%), Gaps = 2/245 (0%)
Frame = +2
Query: 125 AAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQK 304
+A+Y G VT+IPG GIGPE+ + V+ +F A VP+++EEV V++ + +
Sbjct: 48 SAKYG-GRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVSSNADEEDI----RN 102
Query: 305 AIDSVNANKIGLKGPLMTP--VGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVD 478
AI ++ N++ LKG + T + ++S N LR DLYANV CKSL G+ T + ++D
Sbjct: 103 AIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKDID 162
Query: 479 VVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKA 658
++ +RENTEGEYS +EHE V GVV+S+K+IT+ S R+AE+AF+ A+E+ RKKVTAVHKA
Sbjct: 163 ILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKA 222
Query: 659 NIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSD 838
NIM++ GLFL+CCRE+A +YP I FE + + +V P +FDV+VMPNLYG+I+++
Sbjct: 223 NIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNN 282
Query: 839 MCSGL 853
+C+GL
Sbjct: 283 VCAGL 287
>UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase family protein; n=9; Bacteria|Rep:
Isopropylmalate/isohomocitrate dehydrogenase family
protein - Synechococcus sp. (strain JA-3-3Ab)
(Cyanobacteria bacteriumYellowstone A-Prime)
Length = 368
Score = 240 bits (588), Expect = 3e-62
Identities = 122/256 (47%), Positives = 175/256 (68%), Gaps = 22/256 (8%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFG--IPQKAIDSVNA 325
+VTLIPG GIGPE+T A+ + EA+ V +EW V+ V + K+G +P + ++S+
Sbjct: 4 RVTLIPGDGIGPEVTRAMTTVLEASGVDLEWIRVEA-GVEVIE-KYGTPLPPQVLESIRE 61
Query: 326 NKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTE 505
++ +KGP+ TPVG G+RS+N+A+RKE DLYAN+RP KSL GIK+ + ++D+V +RENTE
Sbjct: 62 TRVAIKGPIGTPVGTGFRSVNVAIRKELDLYANLRPAKSLPGIKSPFQDIDLVVVRENTE 121
Query: 506 GEYSGIEHE--------------------IVDGVVQSIKLITEEASTRVAEFAFQFAREN 625
Y+GIE E I +G IK I+E S R+ +FAF++AR+N
Sbjct: 122 DLYAGIEFERGTPEAAHAREEMMRLSGKFIREGSAIGIKPISEFGSRRIVKFAFEYARQN 181
Query: 626 KRKKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLV 805
RKKVTAVHKANIM+ + GLFL+ RE+A +YPDI+FE + +CL ++Q P +DVLV
Sbjct: 182 GRKKVTAVHKANIMKFTDGLFLQVAREVAQEYPDIEFEDLIVDNMCLQLMQKPQLYDVLV 241
Query: 806 MPNLYGDIMSDMCSGL 853
+ NLYGDI+SD+C+G+
Sbjct: 242 LTNLYGDIISDLCAGM 257
>UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2;
Bacteria|Rep: Isocitrate dehydrogenase - Gloeobacter
violaceus
Length = 359
Score = 233 bits (571), Expect = 3e-60
Identities = 114/254 (44%), Positives = 169/254 (66%), Gaps = 20/254 (7%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 331
+VTLI G GIGPE+T A + + +A + EW VD A +P I++V A+
Sbjct: 5 RVTLIRGDGIGPEVTQAARIVLDATGIDFEWVVVDAGAEVMEKSGTPLPAPVIEAVRASD 64
Query: 332 IGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGE 511
+KGP+ TP G G RS+N+ALR+ DLYAN+RP ++L G+ + YDN+D+V +RENTE
Sbjct: 65 AAIKGPITTPAGSGIRSVNVALRRALDLYANLRPARTLPGVHSRYDNIDLVVVRENTEDL 124
Query: 512 YSGIEH--------EIVDGVVQ------------SIKLITEEASTRVAEFAFQFARENKR 631
YSGIE E+++ +++ ++K I+ EAS R+A FAF++AR + R
Sbjct: 125 YSGIEFEKNSPQALEVIEMLMRLGGKKIFPRSGLAVKPISSEASERIARFAFEYARRHAR 184
Query: 632 KKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMP 811
+KVTAVHKANI++ + GLFL R++A++YPD++FE R + +C+ +VQ P +DVLV+P
Sbjct: 185 RKVTAVHKANILKHTDGLFLEAARQVASEYPDVEFEDRIVDNLCMQLVQRPESYDVLVLP 244
Query: 812 NLYGDIMSDMCSGL 853
NLYGDI+SD+ +GL
Sbjct: 245 NLYGDIVSDLTAGL 258
>UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1;
Kluyveromyces lactis|Rep: Isocitrate dehydrogenase [NAD]
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Kluyveromyces lactis (Yeast) (Candida sphaerica)
Length = 361
Score = 233 bits (569), Expect = 5e-60
Identities = 114/235 (48%), Positives = 160/235 (68%), Gaps = 2/235 (0%)
Frame = +2
Query: 155 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKI 334
VTLIPG G+G E+T +V KIFE +PI+WE +D++ + + Q+A++S+ NK+
Sbjct: 32 VTLIPGDGVGKEVTDSVVKIFENENIPIDWETIDISGLENTENV----QRAVESLKRNKV 87
Query: 335 GLKGPLMTPVGK-GYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGE 511
GLKG TP + G+ SLN+ALRK+ D++ANV KS+ G+KT +N+D+V IRENTEGE
Sbjct: 88 GLKGIWHTPADQTGHGSLNVALRKQLDIFANVALFKSIPGVKTRLNNIDMVIIRENTEGE 147
Query: 512 YSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSXGLFL 691
YSG+EHE V GVV+S+K++T S R+A FAF FA +N RK V AVHKANIM++ GLF
Sbjct: 148 YSGLEHESVPGVVESLKIMTRAKSERIARFAFDFALKNNRKSVCAVHKANIMKLGDGLFR 207
Query: 692 RCCREL-ATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGL 853
E+ A +YP++ + + + V P +FDVLV PNLYG I+ ++ S L
Sbjct: 208 NTVNEIGANEYPELDVKNIIVDNASMQAVAKPHQFDVLVTPNLYGSILGNIGSAL 262
>UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit
beta, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=61;
Fungi/Metazoa group|Rep: Isocitrate dehydrogenase [NAD]
subunit beta, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 385
Score = 231 bits (565), Expect = 2e-59
Identities = 110/235 (46%), Positives = 165/235 (70%), Gaps = 2/235 (0%)
Frame = +2
Query: 155 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKI 334
VT++PG G+GPE+ AV+++F+AA VP+E++E ++ V+ + + Q + S+ NK+
Sbjct: 51 VTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQ-VLSSMKENKV 109
Query: 335 GLKGPLMTPVG-KG-YRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEG 508
+ G + TP+ KG S ++ LR++ DL+ANV KSL G T ++N+D+V IRE TEG
Sbjct: 110 AIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEG 169
Query: 509 EYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSXGLF 688
EYS +EHE GV++ +K++T S R+A+FAF +A + R KVTAVHKANIM++ GLF
Sbjct: 170 EYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLF 229
Query: 689 LRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGL 853
L+CC E+A YP IKFE + C+ +VQ+P +FDVLVMPNLYG+I+ ++ +GL
Sbjct: 230 LQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGL 284
>UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=32;
Dikarya|Rep: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 360
Score = 228 bits (558), Expect = 1e-58
Identities = 120/261 (45%), Positives = 170/261 (65%), Gaps = 2/261 (0%)
Frame = +2
Query: 77 MAARIIRKIVPATRAGAAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVD 256
+A R + A R +Y G VTLIPG G+G EIT +V+ IFEA +PI+WE ++
Sbjct: 6 IAKRTLATAAQAERTLPKKYG-GRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETIN 64
Query: 257 VTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGK-GYRSLNLALRKEFDLYANVRP 433
+ + D K G+ +A++S+ NKIGLKG TP + G+ SLN+ALRK+ D+YANV
Sbjct: 65 I---KQTDHKEGV-YEAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVAL 120
Query: 434 CKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQF 613
KSL+G+KT ++D++ IRENTEGE+SG+EHE V GVV+S+K++T + R+A FAF F
Sbjct: 121 FKSLKGVKTRIPDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDF 180
Query: 614 ARENKRKKVTAVHKANIMRMSXGLFLRCCRELATK-YPDIKFEXRYLXTVCLNMVQDPSK 790
A++ RK VTAVHKANIM++ GLF E+ K YPDI + + V P +
Sbjct: 181 AKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQ 240
Query: 791 FDVLVMPNLYGDIMSDMCSGL 853
FDVLV P++YG I+ ++ + L
Sbjct: 241 FDVLVTPSMYGTILGNIGAAL 261
>UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;
Glossina morsitans morsitans|Rep: Isocitrate
dehydrogenase (NAD+) 2 - Glossina morsitans morsitans
(Savannah tsetse fly)
Length = 372
Score = 223 bits (544), Expect = 6e-57
Identities = 110/236 (46%), Positives = 162/236 (68%), Gaps = 4/236 (1%)
Frame = +2
Query: 158 TLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIG 337
TLIPG G+GPE+ +Q++F++A VP+++E ++ V P + + I S+ NK+
Sbjct: 43 TLIPGDGVGPELVQCLQEVFKSADVPVDFECYFLSEVN-PVLSAKL-EDVIASIRKNKVC 100
Query: 338 LKGPLMTP----VGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTE 505
+KG L TP VG+ +SLN+ LR E DLYANV +SL G+KT Y ++D+V IRE TE
Sbjct: 101 IKGVLATPDYSNVGE-LQSLNMKLRNELDLYANVVHARSLPGVKTRYQDIDIVVIREQTE 159
Query: 506 GEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSXGL 685
GEYS +EHE V G+V+ +K+IT + S R+A+FAF +A +N RKKVT+VHKANIM++ GL
Sbjct: 160 GEYSALEHESVPGIVECLKIITAKKSMRIAKFAFDYAIKNSRKKVTSVHKANIMKLGDGL 219
Query: 686 FLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGL 853
FL+ C ++A YP I+F+ + + +V P +FDVLV PNLYG I+ ++ +G+
Sbjct: 220 FLKSCEDMAKLYPRIEFQKMIVDNTTMQIVSHPHQFDVLVTPNLYGSIIDNLFAGI 275
>UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8;
Bilateria|Rep: Isocitrate dehydrogenase - Aedes aegypti
(Yellowfever mosquito)
Length = 393
Score = 220 bits (537), Expect = 4e-56
Identities = 114/239 (47%), Positives = 154/239 (64%), Gaps = 2/239 (0%)
Frame = +2
Query: 143 GVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVT-AVRGPDGKFGIPQKAIDSV 319
G VT++PG GIGPE+ V+++F A VP+++E VD+ A G D + AI S+
Sbjct: 48 GRHTVTMLPGGGIGPELMNYVKEVFRFAGVPVDFEVVDIDPASEGNDDL----EYAITSI 103
Query: 320 NANKIGLKGPLMTPV-GKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRE 496
N + LKG + T G S N+ALR E DLY NV CKS I + NVDVV IR+
Sbjct: 104 KRNGVALKGNIETKSEATGIISRNVALRNELDLYVNVLHCKSFNAIPAHHQNVDVVIIRQ 163
Query: 497 NTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMS 676
NTEGEY+ +EHE V GVV+S+K++T E + RVA +AF+FAR N RKKVT +HKANIM+++
Sbjct: 164 NTEGEYAMLEHESVRGVVESMKVVTVENAARVARYAFEFARANNRKKVTTIHKANIMKLA 223
Query: 677 XGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGL 853
GLFL RE+A YPDI+ + C+ +V +P +FDV+ NLYG I S++ GL
Sbjct: 224 DGLFLSVAREVAKDYPDIQHNDMIIDNCCMQLVSNPHQFDVMNTTNLYGSITSNVLCGL 282
>UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p -
Drosophila melanogaster (Fruit fly)
Length = 402
Score = 210 bits (513), Expect = 3e-53
Identities = 109/255 (42%), Positives = 159/255 (62%), Gaps = 1/255 (0%)
Frame = +2
Query: 92 IRKIVPATRAGAAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVR 271
++K V T +AQY G VT++PG GIGPE+ V++IF PI++E +D+
Sbjct: 40 LQKKVTGTDIPSAQYG-GRHAVTMLPGGGIGPELMGYVREIFRYCGAPIDFEVIDIDP-- 96
Query: 272 GPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYR-SLNLALRKEFDLYANVRPCKSLE 448
+G + AI S+ N + LKG + T S N+A+R E DLY NV CKS
Sbjct: 97 STEGNDDLDY-AITSIKRNGVALKGNIETKSQSLTEVSRNVAIRNELDLYVNVVHCKSYP 155
Query: 449 GIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENK 628
GI + ++DVV IR+NT+GEY+ +EHE V G+V+S+K++T E + RVA +AF+FAR+N
Sbjct: 156 GIPARHHDIDVVLIRQNTDGEYAMLEHESVPGIVESMKVVTVENAERVARYAFEFARQNN 215
Query: 629 RKKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVM 808
RKKVT +HKANIM++S GLFL + YP+++ + C+ V +P +FDV+ M
Sbjct: 216 RKKVTTIHKANIMKLSDGLFLEVANRVHKDYPELEHNNMIIDNTCMQSVSNPHQFDVMNM 275
Query: 809 PNLYGDIMSDMCSGL 853
NLYG I+S++ GL
Sbjct: 276 TNLYGTIVSNVLCGL 290
>UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=5; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) - Thermus
thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Length = 496
Score = 196 bits (477), Expect = 8e-49
Identities = 100/240 (41%), Positives = 146/240 (60%), Gaps = 3/240 (1%)
Frame = +2
Query: 143 GVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDG-KFGIPQKAIDSV 319
G + +T+IPG GIGPE A K+ EAAK P+ +E + A G G+PQ+ I+S+
Sbjct: 18 GRKLITVIPGDGIGPECVEATLKVLEAAKAPLAYEVREAGASVFRRGIASGVPQETIESI 77
Query: 320 NANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN--VDVVTIR 493
++ LKGPL TPVG G +S N+ LRK F+ YANVRP + + T Y +D+V +R
Sbjct: 78 RKTRVVLKGPLETPVGYGEKSANVTLRKLFETYANVRPVREFPNVPTPYAGRGIDLVVVR 137
Query: 494 ENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRM 673
EN E Y+GIEH V Q++KLI+ + S ++ FAF+ AR RKKV K+NIM++
Sbjct: 138 ENVEDLYAGIEHMQTPSVAQTLKLISWKGSEKIVRFAFELARAEGRKKVHCATKSNIMKL 197
Query: 674 SXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGL 853
+ G R ++A +YPDI+ + +V+ P +F+V+V N+ GDI+SD+ SGL
Sbjct: 198 AEGTLKRAFEQVAQEYPDIEAVHIIVDNAAHQLVKRPEQFEVIVTTNMNGDILSDLTSGL 257
>UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep:
CG3483 protein - Drosophila melanogaster (Fruit fly)
Length = 391
Score = 195 bits (476), Expect = 1e-48
Identities = 103/249 (41%), Positives = 150/249 (60%), Gaps = 1/249 (0%)
Frame = +2
Query: 110 ATRAGAAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKF 289
A AG+ + KVTLI G G+G E+ AVQ++ A K PIEW+ D + D
Sbjct: 57 AKSAGSTDSAKKTTKVTLINGEGVGRELMDAVQEVICAVKAPIEWDVHDEFKAKDSDD-- 114
Query: 290 GIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYD 469
+ + + S+ ANK+G+KGP+ + R +RK+F +A V C +EG+ + Y
Sbjct: 115 -VSPEVLKSLRANKVGIKGPVDS------RHWQRQIRKQFAQFAYVSLCSHIEGLDSPYG 167
Query: 470 NVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAV 649
+ DVV IR+ EG+YSGIEH +V GV+Q+IK+ T + R+AEF F +A +NKRK++T
Sbjct: 168 DFDVVIIRDQMEGDYSGIEHLVVPGVMQTIKVSTTAGAARIAEFVFNYAVKNKRKRITVA 227
Query: 650 HKANIMRMSXGLFLRCCRELATKY-PDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGD 826
HKANIMRM+ G FL R A K+ D+ FE RYL T L ++ P K DV+V ++YGD
Sbjct: 228 HKANIMRMTDGNFLEAMRAEADKHVDDVLFEERYLDTCILKILLKPHKCDVMVSSSMYGD 287
Query: 827 IMSDMCSGL 853
++ + G+
Sbjct: 288 VLRVIAGGM 296
>UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68;
Bacteria|Rep: Isocitrate dehydrogenase -
Janthinobacterium sp. (strain Marseille) (Minibacterium
massiliensis)
Length = 349
Score = 193 bits (471), Expect = 4e-48
Identities = 102/241 (42%), Positives = 147/241 (60%), Gaps = 8/241 (3%)
Frame = +2
Query: 155 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWE--EVDVTAVRGPDGKFGIPQKAIDSVNAN 328
VTLIPG GIGPEI V ++F+A P WE + V A+ G +PQ +DS+
Sbjct: 12 VTLIPGDGIGPEIVDVVVRVFDALGNPFAWETQQAGVNALE-KSGDL-LPQTTLDSIGRT 69
Query: 329 KIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEG 508
+ LKGPL TP+G G+RS+N+ LR+ F LYANVRP +++ Y+ +D+V +REN EG
Sbjct: 70 GLALKGPLSTPIGGGFRSVNVRLRETFQLYANVRPARTIVP-GGRYEKIDLVLVRENLEG 128
Query: 509 EYSGIEHEIVDG-----VVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRM 673
Y G EH + G V + + T S R+++FAF +A N R+KVT VHKAN+++
Sbjct: 129 LYVGHEHYVPIGDDAHAVAMATGINTRAGSRRISKFAFDYAVRNNRRKVTIVHKANVLKA 188
Query: 674 SXGLFLRCCRELATKYPD-IKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSG 850
GLFL +++ Y D I+F R + + +V +P +FDV+V NL+GDI+SD +G
Sbjct: 189 LTGLFLETAKQVGLNYADQIEFNDRIVDACAMQLVLNPWQFDVIVSTNLFGDILSDQIAG 248
Query: 851 L 853
L
Sbjct: 249 L 249
>UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1;
Planctomyces maris DSM 8797|Rep: Isocitrate
dehydrogenase, putative - Planctomyces maris DSM 8797
Length = 390
Score = 157 bits (380), Expect(2) = 6e-47
Identities = 87/222 (39%), Positives = 133/222 (59%), Gaps = 26/222 (11%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 331
KVTLIPG G+GPEI A +K +A V I+W+ V + + + G+P + +DS+ ANK
Sbjct: 3 KVTLIPGDGVGPEIAEATRKCVDATGVKIDWD-VQECGIEVIEAEGGVPDRVMDSIRANK 61
Query: 332 IGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY--DNVDVVTIRENTE 505
I LK P+ TP+GKG+RS+N+ LR+E LYA +RPCK+ +G++T + NVD+V +RENTE
Sbjct: 62 IALKAPITTPIGKGFRSVNVFLRQELGLYACIRPCKTYKGVRTYFADSNVDLVVVRENTE 121
Query: 506 GEYSGIEHEI------------------------VDGVVQSIKLITEEASTRVAEFAFQF 613
Y+G+E + +D SIK ++ + + + +AF++
Sbjct: 122 DLYAGVEFQAGQEKTAELIKKINEFATGKKINTPLDETGVSIKPMSYQGTRDICNYAFKY 181
Query: 614 ARENKRKKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFE 739
A +NKR+ VT++ KANIM+ + GL+ R +A Y KFE
Sbjct: 182 AVDNKRQSVTSICKANIMKFTDGLWYDETRAVAKAY-GAKFE 222
Score = 54.4 bits (125), Expect(2) = 6e-47
Identities = 21/42 (50%), Positives = 31/42 (73%)
Frame = +2
Query: 728 IKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGL 853
I++ R + +C+ +VQ P +DVLV NLYGDI+SD+C+GL
Sbjct: 247 IEYNERLIDNMCMQLVQKPELYDVLVTSNLYGDILSDLCAGL 288
>UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
- Archaeoglobus fulgidus
Length = 326
Score = 188 bits (457), Expect = 2e-46
Identities = 93/236 (39%), Positives = 143/236 (60%)
Frame = +2
Query: 146 VRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNA 325
++K+ +IPG GIG E+ A I E +P E+ D +P + +++
Sbjct: 1 MKKIVVIPGDGIGKEVMEAAMLILEKLDLPFEYSYYDAGDEALEKYGKALPDETLEACRK 60
Query: 326 NKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTE 505
+ L G G+ + + LR+E +ANVRP K++EGI+ LY +D+V +RENTE
Sbjct: 61 SDAVLFGA----AGETAADVIVRLRRELGTFANVRPAKAIEGIECLYPGLDIVVVRENTE 116
Query: 506 GEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSXGL 685
Y G E D V ++I++IT EAS R+A +AF+ A+ RKKVTA+HKAN+M+ + GL
Sbjct: 117 CLYMGFEFGFGD-VTEAIRVITREASERIARYAFELAKREGRKKVTALHKANVMKKTCGL 175
Query: 686 FLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGL 853
F CRE+A YP+I++ Y+ C+ +V DP +FDV+V N++GDI+SD+ +GL
Sbjct: 176 FRDVCREVAKDYPEIQYNDYYIDAACMYLVMDPFRFDVIVTTNMFGDIVSDLAAGL 231
>UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase; n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Isopropylmalate/isohomocitrate dehydrogenase -
Candidatus Nitrosopumilus maritimus SCM1
Length = 337
Score = 176 bits (428), Expect = 7e-43
Identities = 91/235 (38%), Positives = 147/235 (62%), Gaps = 3/235 (1%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAI--DSVNA 325
K++LI G GIGPE++ + + E ++ + +T + D KA+ D+V+A
Sbjct: 3 KISLITGDGIGPELSDSAVSVLETIHDKLDLK-FGITKLSAGDKALEQTGKALPDDTVSA 61
Query: 326 NKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTE 505
K + PVG+ + + LR+ DLYAN+RP KS + L D++D+V +RENTE
Sbjct: 62 IKQS-DACMKAPVGESAADVIVVLRRMLDLYANIRPAKSYPHMPALRDDIDMVIVRENTE 120
Query: 506 GEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFAR-ENKRKKVTAVHKANIMRMSXG 682
Y+G E + D V ++++I+E+AS R+A++AF+ A+ N +KKVT VHK+N+MR++ G
Sbjct: 121 DLYTGKEFSLGDSSV-ALRIISEQASKRIAKYAFETAKMRNDKKKVTCVHKSNVMRVTDG 179
Query: 683 LFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCS 847
+F + C E++ YPDI FE Y+ +N+++ P +FDV+V NL+GDI+SD S
Sbjct: 180 MFAKACTEVSKDYPDISFEQMYVDACAMNLIRQPQEFDVVVTTNLFGDILSDESS 234
>UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=6; Rickettsiales|Rep: Isocitrate dehydrogenase,
NADP-dependent - Orientia tsutsugamushi (strain Boryong)
(Rickettsia tsutsugamushi)
Length = 519
Score = 175 bits (427), Expect = 9e-43
Identities = 90/233 (38%), Positives = 135/233 (57%), Gaps = 2/233 (0%)
Frame = +2
Query: 155 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDV-TAVRGPDGKFGIPQKAIDSVNANK 331
VT+ G GIGPEI AV + + A VP+ E +++ + +GI + + K
Sbjct: 7 VTIAYGDGIGPEIMEAVVYVLKEAAVPLRLETIEIGEKLYNKYYTYGITEDTWSQIFRTK 66
Query: 332 IGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRP-CKSLEGIKTLYDNVDVVTIRENTEG 508
LKGP+ TP G GY+SLN+ LRK LYANVRP C + T +DVV IREN E
Sbjct: 67 ALLKGPVTTPQGGGYKSLNVTLRKTLGLYANVRPSCSYFPFVNTSAPEIDVVIIRENEED 126
Query: 509 EYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSXGLF 688
Y+GIE+ +S+KLI+ S ++ FAF++A +N RK ++ K NIM+ + G+F
Sbjct: 127 LYAGIEYHHTADTYESVKLISRSGSEKIIRFAFEYALKNNRKTISCFSKDNIMKFTDGIF 186
Query: 689 LRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCS 847
+ E+A++Y +I+ + + ++ P KFDV+V NLYGDI+SD+ +
Sbjct: 187 HKTFNEIASQYSNIQVDHYLIDIGSARLISSPQKFDVIVTSNLYGDILSDIAA 239
>UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3;
Rickettsiales|Rep: Isocitrate dehydrogenase - Anaplasma
marginale (strain St. Maries)
Length = 488
Score = 175 bits (425), Expect = 2e-42
Identities = 92/233 (39%), Positives = 138/233 (59%), Gaps = 2/233 (0%)
Frame = +2
Query: 155 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVR-GPDGKFGIPQKAIDSVNANK 331
+T+ G G+GPEI AV I + A+ + E VD+ + + GI A +S++ +
Sbjct: 10 ITVAYGDGVGPEIMEAVLFILKEARADVSIETVDIGHNQYKKEWTSGIAPSAWESISRTR 69
Query: 332 IGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKS-LEGIKTLYDNVDVVTIRENTEG 508
+ LK P MTP G G++SLN+ALR+ LY NVRPC S + T + ++DVV IREN E
Sbjct: 70 LLLKAPTMTPQGSGHKSLNVALRQRLGLYVNVRPCVSYFPVVGTKHPDLDVVIIRENEED 129
Query: 509 EYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSXGLF 688
YSG+EH++ + + +K+ T AS ++ +AF +AR + RKKVT K NIM+M+ G+
Sbjct: 130 TYSGVEHKLSEDTHECVKISTRSASEKICAYAFNYARAHNRKKVTCFVKDNIMKMTDGIL 189
Query: 689 LRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCS 847
++A YPDI+ + + +P FDV+V NLYGDI+SD+ S
Sbjct: 190 HASFDKVAKGYPDIEANYYIVDVGMAKIASNPEDFDVVVTTNLYGDIVSDIVS 242
>UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Thermoprotei|Rep: 3-isopropylmalate dehydrogenase -
Sulfolobus tokodaii
Length = 337
Score = 174 bits (424), Expect = 2e-42
Identities = 97/235 (41%), Positives = 138/235 (58%), Gaps = 4/235 (1%)
Frame = +2
Query: 155 VTLIPGHGIGPEITVA----VQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVN 322
V LI G GIGPEI + KI E +PIE+ EV+ +P+ ++ ++
Sbjct: 5 VALIQGDGIGPEIVSKSKRILAKINELYSLPIEYIEVEAGDRALARYGEALPKDSLKIID 64
Query: 323 ANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENT 502
I LKGP VG+ + + LR+ +D+YAN+RP KS+ GI T Y NVD++ +RENT
Sbjct: 65 KADIILKGP----VGESAADVVVKLRQIYDMYANIRPAKSIPGIDTKYGNVDILIVRENT 120
Query: 503 EGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSXG 682
E Y G EH + DGV +K+IT AS R+A+ FA +RKKVT VHKAN+MR++ G
Sbjct: 121 EDLYKGFEHIVSDGVAVGMKIITRFASERIAKVGLNFAL-RRRKKVTCVHKANVMRITDG 179
Query: 683 LFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCS 847
LF CR + +++ Y+ N+V++P FDV+V N+YGDI+SD S
Sbjct: 180 LFAEACRSVLK--GKVEYSEMYVDAAAANLVRNPQMFDVIVTENVYGDILSDEAS 232
>UniRef50_Q2UP37 Cluster: Isocitrate/isopropylmalate dehydrogenase;
n=1; Aspergillus oryzae|Rep: Isocitrate/isopropylmalate
dehydrogenase - Aspergillus oryzae
Length = 350
Score = 167 bits (407), Expect = 2e-40
Identities = 89/248 (35%), Positives = 143/248 (57%), Gaps = 14/248 (5%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 331
++ ++ G+GIGPEIT A ++ EA + EW+ + + +P + I + K
Sbjct: 2 RIGVLKGNGIGPEITAATIRVIEATGIQPEWDFIPIADEAVRLYGHALPPQVIQRIKDVK 61
Query: 332 IGLKGPLMTPVGKG-------------YRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN 472
+K PL+ G Y S+N A+R+E +L+ N RP + GI ++
Sbjct: 62 FCIKAPLLAEKLHGRISCTQTDGSVVTYPSINNAIRRELNLFVNPRPIRGYVGISGRHEK 121
Query: 473 VDVVTIRENTEGEYSGIEHEIVDGVV-QSIKLITEEASTRVAEFAFQFARENKRKKVTAV 649
+D+V +RE TE Y G E + DG ++IK +T AS +V+++AF++AR++ RKKV+ +
Sbjct: 122 MDMVIMREITEDTYIGWEKPLEDGAAAEAIKRVTRSASWKVSQYAFEYARKHGRKKVSCL 181
Query: 650 HKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDI 829
HKAN++ + GLFLR +E+A YPDI + + C ++V+DP FDV+V N YGDI
Sbjct: 182 HKANVLHETDGLFLRTFQEVARLYPDIVGDDMMIDAACYSVVRDPCWFDVVVTVNQYGDI 241
Query: 830 MSDMCSGL 853
SD+ +GL
Sbjct: 242 FSDLAAGL 249
>UniRef50_Q4UKR1 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=29; cellular organisms|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Rickettsia felis (Rickettsia azadi)
Length = 483
Score = 165 bits (401), Expect = 1e-39
Identities = 89/233 (38%), Positives = 134/233 (57%), Gaps = 2/233 (0%)
Frame = +2
Query: 155 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDV-TAVRGPDGKFGIPQKAIDSVNANK 331
+T+ G GIGPEI AV I A+ I E ++V + GI +++ +S+
Sbjct: 7 ITIAYGDGIGPEIMEAVLYILRKAEARIRLETIEVGEKLYKKHYTSGISEESWESIQRTG 66
Query: 332 IGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIK-TLYDNVDVVTIRENTEG 508
I LK P+ TP G GY+SLN+ +RK L+AN+RP S TL+ ++++ IREN E
Sbjct: 67 IILKAPITTPQGGGYKSLNVTIRKTLQLFANIRPSVSFHPFTMTLHPHLNLTIIRENEED 126
Query: 509 EYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSXGLF 688
Y+GIE+ + +SIKLI+ ++ +AF++A +N RKKVT + K NIM+ S G+F
Sbjct: 127 LYAGIEYRQTHNMYESIKLISHTGCEKIIRYAFEYAVKNNRKKVTCLSKDNIMKFSDGVF 186
Query: 689 LRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCS 847
+ E+A +YP I E + + P FDV+V NLYGDI+SD+ +
Sbjct: 187 HKIFNEIAKEYPQINNEHYIIDIGTARLATKPEIFDVIVTSNLYGDIISDVAA 239
>UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanococcus jannaschii
Length = 333
Score = 161 bits (391), Expect = 2e-38
Identities = 88/240 (36%), Positives = 139/240 (57%), Gaps = 5/240 (2%)
Frame = +2
Query: 146 VRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDV-TAVRGPDGKFGIPQKAIDSVN 322
+ K+ +I G GIG E+ A ++ EA +P E+ + V GK +P++ I++
Sbjct: 1 MHKICVIEGDGIGKEVVPATIQVLEATGLPFEFVYAEAGDEVYKRTGK-ALPEETIETA- 58
Query: 323 ANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENT 502
+ L G+ + + LR D YAN+RP K+ +G+K L ++D V +RENT
Sbjct: 59 ---LDCDAVLFGAAGETAADVIVKLRHILDTYANIRPVKAYKGVKCLRPDIDYVIVRENT 115
Query: 503 EGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRK----KVTAVHKANIMR 670
EG Y GIE EI +G+ + ++ITE+A R+ FAF ARE K+ KVT HKAN+++
Sbjct: 116 EGLYKGIEAEIDEGITIATRVITEKACERIFRFAFNLARERKKMGKEGKVTCAHKANVLK 175
Query: 671 MSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSG 850
++ GLF + ++A +Y DIK E Y+ + + ++ P FDV+V NL+GDI+SD +G
Sbjct: 176 LTDGLFKKIFYKVAEEYDDIKAEDYYIDAMNMYIITKPQVFDVVVTSNLFGDILSDGAAG 235
>UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanobacterium thermoautotrophicum
Length = 329
Score = 158 bits (383), Expect = 2e-37
Identities = 82/234 (35%), Positives = 135/234 (57%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 331
K+ +IPG GIG E+ A I + +E+ D +P++ +++V +
Sbjct: 5 KIAVIPGDGIGVEVMEAALHILNTLDLDLEFIHADAGDACLKRTGTALPEETLEAVGEAR 64
Query: 332 IGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGE 511
L G G+ + + LR+EFDL+AN+RP KSL G+ LY ++D V +RENTE
Sbjct: 65 ATLFGA----AGESAADVIVRLRREFDLFANLRPVKSLPGVPCLYPDLDFVIVRENTEDL 120
Query: 512 YSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSXGLFL 691
Y G E +G V ++IT AS R+++FAFQ+A++ +KVTAVHKAN+++ + G+F
Sbjct: 121 YVGDEEYTPEGAVAK-RIITRTASRRISQFAFQYAQKEGMQKVTAVHKANVLKKTDGIFR 179
Query: 692 RCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGL 853
++A++YP ++ Y+ + ++ P +F +V NL+GDI+SD +GL
Sbjct: 180 DEFYKVASEYPQMEATDYYVDATAMYLITQPQEFQTIVTTNLFGDILSDEAAGL 233
>UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH).; n=1;
Bos taurus|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH). - Bos Taurus
Length = 260
Score = 151 bits (367), Expect = 2e-35
Identities = 67/148 (45%), Positives = 105/148 (70%)
Frame = +2
Query: 410 DLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTR 589
DL ANV +S ++T + N+D++ +R+NTEGEYS +E E ++ VV+S++ +T+ R
Sbjct: 17 DLCANVVQFESQPRVETRHKNIDILVVRDNTEGEYSNLEDESMNRVVESLRTVTKAKCLR 76
Query: 590 VAEFAFQFARENKRKKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLN 769
+AE+AFQ A KKVTA +KANIMR+ LF++CCRE+A+ YP + FE + +
Sbjct: 77 LAEYAFQLAHRMGCKKVTATYKANIMRLGDCLFIQCCREVASHYPQLSFEGMIVGNTPMQ 136
Query: 770 MVQDPSKFDVLVMPNLYGDIMSDMCSGL 853
+V P +FDV+VMP+LYG+I++++C+GL
Sbjct: 137 LVSGPQQFDVMVMPSLYGNIVNNVCTGL 164
>UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;
n=1; Ignicoccus hospitalis KIN4/I|Rep: 3-isopropylmalate
dehydrogenase - Ignicoccus hospitalis KIN4/I
Length = 343
Score = 142 bits (343), Expect = 1e-32
Identities = 86/242 (35%), Positives = 143/242 (59%), Gaps = 11/242 (4%)
Frame = +2
Query: 155 VTLIPGHGIGPEITVA----VQKIFEAAKVPIEWEEVDVTAVRGPDGKFG--IPQKAIDS 316
V +I G GIGPE+ A ++KI E K+P+E+ V V A K+G +P+++ +
Sbjct: 4 VAVIEGDGIGPEVVGATLKVLEKIRETFKLPLEF--VFVEAGDRAKEKYGEALPKESYER 61
Query: 317 VNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRE 496
+ LKGP VG+ + + LR+E DL+AN+RP K L G+ L +NVD++ +RE
Sbjct: 62 LLRADAILKGP----VGETAADVIVRLRRELDLFANIRPAKVLPGVPALKENVDLIIVRE 117
Query: 497 NTEGEYSGIEH-----EIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKAN 661
N E Y G E+ + V ++L +E + RVA+ A ++A+ +R KVT VHKAN
Sbjct: 118 NIEDLYVGAENLLPQTSLGHKVAVGLRLASERETRRVAKVAAEYAKA-RRNKVTIVHKAN 176
Query: 662 IMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDM 841
+MR++ GLF +E+ + ++ + Y+ + +V+ P +FDV++ PN++GDI+SD+
Sbjct: 177 VMRVTCGLFRDVAKEV-LEAEGVEVDEMYVDAAAMELVRRPERFDVMLTPNVFGDILSDL 235
Query: 842 CS 847
+
Sbjct: 236 AA 237
>UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenase
family protein; n=6; Archaea|Rep:
Isocitrate/isopropylmalate dehydrogenase family protein
- Methanosarcina acetivorans
Length = 342
Score = 140 bits (340), Expect = 3e-32
Identities = 77/240 (32%), Positives = 137/240 (57%), Gaps = 5/240 (2%)
Frame = +2
Query: 149 RKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPD--GKFGIPQKAIDSVN 322
+ +I G G+GPE+ A+ K+ AA +E+ + A + G +P + ++
Sbjct: 3 KTAAVIKGDGVGPELVEAMLKVANAAGTDVEFVMCEAGAGWWEEHGGNSLVPDETWQILD 62
Query: 323 ANKIGLKGPLMTPVGKGY-RSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIREN 499
++ KGP TP G G RS+ +++R+++DLYANVRP K+ +V++V +RE
Sbjct: 63 SSDACFKGPTTTPGGIGSPRSVAVSIRRKYDLYANVRPIKTFPNSNAPLGDVEMVCVREG 122
Query: 500 TEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSX 679
TEG Y G E ++ D V +I+ IT AS ++A +AF+ A+ V +HK+NI++++
Sbjct: 123 TEGLYIGEEIQLTDDVSIAIRKITRTASGKIARYAFEEAKRRGYDTVVPIHKSNILKLTC 182
Query: 680 GLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFD--VLVMPNLYGDIMSDMCSGL 853
G FL ++A YP+I+ ++ + ++++P F+ VL+ NL+ D++S+ CS L
Sbjct: 183 GSFLEEVEKVAQDYPNIEVWPYHIDNIAQQLIKNPQIFNKKVLLSTNLFMDVISEECSAL 242
>UniRef50_Q9RTT2 Cluster: Isocitrate dehydrogenase, putative; n=2;
Deinococcus|Rep: Isocitrate dehydrogenase, putative -
Deinococcus radiodurans
Length = 333
Score = 137 bits (332), Expect = 3e-31
Identities = 77/237 (32%), Positives = 129/237 (54%), Gaps = 3/237 (1%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 331
++ LI G GIG E+ A +++ EAA E+ + D +P+ D+V
Sbjct: 5 RICLIEGDGIGHEVIPAAKRVLEAAGFDAEYVHAEAGYEYFLDHGTSVPEATYDAVENTD 64
Query: 332 IGLKGPLMTPVGK---GYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENT 502
L G +P G+ G+ LR++++LYANVRP K+ + Y+NVD+V +RENT
Sbjct: 65 ATLFGAATSPSGEKPAGFFGAIRHLRQKYNLYANVRPTKT-RPVPHSYENVDLVIVRENT 123
Query: 503 EGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSXG 682
+G Y E D + +IT EAS R+ +FA A + + K++T VHK+N++ ++ G
Sbjct: 124 QGLYVEQERRYGDTAIADT-VITREASDRIGKFAADLAMK-RSKRLTVVHKSNVLPVTQG 181
Query: 683 LFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGL 853
LF+ + + + + +V++P +FDV+VM N++GDI+SD+ +GL
Sbjct: 182 LFMNTILDHTKTVEGLSTSTMIVDNAAMQLVRNPQQFDVMVMTNMFGDILSDLAAGL 238
>UniRef50_Q58991 Cluster: Threo-isocitrate dehydrogenase [NAD]; n=9;
Methanococcales|Rep: Threo-isocitrate dehydrogenase
[NAD] - Methanococcus jannaschii
Length = 347
Score = 136 bits (328), Expect = 9e-31
Identities = 94/255 (36%), Positives = 142/255 (55%), Gaps = 21/255 (8%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDG-----KFG--IPQKAI 310
KV +I G GIG E+ I EA K+ E E ++ ++G G K+G +P+ I
Sbjct: 3 KVCVIEGDGIGKEV------IPEAIKILNELGEFEI--IKGEAGLECLKKYGNALPEDTI 54
Query: 311 DSVNANKIGLKGPLMTPVG---KGYRSLNLALRKEFDLYANVRPCKSLEGIKTL------ 463
+ I L G + +P + Y+S + LRK F LYANVRP + GI L
Sbjct: 55 EKAKEADIILFGAITSPKPGEVQNYKSPIITLRKMFHLYANVRPINNF-GIGQLIGKIAD 113
Query: 464 YD-----NVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENK 628
Y+ N+D+V IRENTE Y G E D + ++IT + S R+ FAF++A +N
Sbjct: 114 YEFLNAKNIDIVIIRENTEDLYVGRERLENDTAIAE-RVITRKGSERIIRFAFEYAIKNN 172
Query: 629 RKKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVM 808
RKKV+ +HKAN++R++ GLFL E+ Y +I+ + + + +N+++ P KFDV+V
Sbjct: 173 RKKVSCIHKANVLRITDGLFLEVFNEIKKHY-NIEADDYLVDSTAMNLIKHPEKFDVIVT 231
Query: 809 PNLYGDIMSDMCSGL 853
N++GDI+SD S L
Sbjct: 232 TNMFGDILSDEASAL 246
>UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodococcus sp. (strain RHA1)
Length = 365
Score = 132 bits (318), Expect = 1e-29
Identities = 80/251 (31%), Positives = 136/251 (54%), Gaps = 17/251 (6%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAAKVP-----IEWEEVDVTAVRGPDGKFGIPQKAIDS 316
++ ++ G GIG EI A Q++ AA V ++W E+ + IP + +
Sbjct: 12 RIGVLLGDGIGHEIVPATQRVVSAAVVAAGGGAVDWVELPLGLGAIESHGTPIPDSTLSA 71
Query: 317 VNANKIGLKGPLMTPVG----KGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVV 484
++A + GP + +G + +RK FDL+AN+RP +SLEG+ + ++D+V
Sbjct: 72 LDALDAWILGPHDSAAYPEPFRGRLTPGGVVRKRFDLFANIRPARSLEGVASTVPDMDLV 131
Query: 485 TIRENTEGEYS-------GIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVT 643
+RENTEG Y+ E V ++ ++T +A R+A AF AR + + VT
Sbjct: 132 IVRENTEGLYADRNMFAGSGEFMPTPDVALAVGVVTRKACERIAHTAFALAR-TRGRHVT 190
Query: 644 AVHKANIMRMSXGLFLRCCRELATK-YPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLY 820
VHKAN++ M+ GLF CRE+ + YPD++ + ++ + ++V+ FDV+V N++
Sbjct: 191 IVHKANVLSMTTGLFRDVCREVGQRDYPDVRIDDEHVDAMTAHLVRRGRDFDVVVTENMF 250
Query: 821 GDIMSDMCSGL 853
GDI+SD+ L
Sbjct: 251 GDILSDLTGEL 261
>UniRef50_Q0W1Q6 Cluster: 2-isopropylmalate dehydrogenase; n=5;
Euryarchaeota|Rep: 2-isopropylmalate dehydrogenase -
Uncultured methanogenic archaeon RC-I
Length = 324
Score = 131 bits (316), Expect = 2e-29
Identities = 82/234 (35%), Positives = 127/234 (54%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 331
K+ ++PG GIG E+ ++ + A E+ V+V R + +++V A
Sbjct: 2 KIAVLPGDGIGREVVPVAHEVLKVALPDAEFLHVEVGNERYVREGVSMSPADLETVKACD 61
Query: 332 IGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGE 511
L G + +P GK YRS+ L LRKE DLYAN+RP +S V+ REN+E
Sbjct: 62 CVLFGAITSPPGKPYRSIILTLRKELDLYANIRPFRS---CPISPRKVNFTIYRENSEDL 118
Query: 512 YSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSXGLFL 691
Y GIE EI +S+++IT +AS R+A A + K+T VHK+N+++ + LF
Sbjct: 119 YMGIE-EITGDEARSVRVITRKASERIARAA---CSKPGIGKLTIVHKSNVLK-ADELFK 173
Query: 692 RCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGL 853
C ++A K ++ FE + T N+V+ P KFD +V N++GDI+SD + L
Sbjct: 174 DACAQVA-KSMNVPFEDMLVDTTAYNLVRAPEKFDTIVTTNMFGDILSDEAAAL 226
>UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2;
Alphaproteobacteria|Rep: Isopropylmalate dehydrogenase -
Oceanicola granulosus HTCC2516
Length = 363
Score = 130 bits (314), Expect = 4e-29
Identities = 81/253 (32%), Positives = 137/253 (54%), Gaps = 19/253 (7%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAAK----VPIEWEEVDVTAVRGPDGKFGIPQKAIDSV 319
K+ ++ G IG EI A ++ AA + I+W +V + A +P+ ++++
Sbjct: 7 KLGILNGDDIGHEIVPASVEVARAAAGKAGLGIDWTDVPIGAAALESHGHTMPEGTMETL 66
Query: 320 NANKIGLKGPLMTPVG-KGYRSLNLA------LRKEFDLYANVRPCKSLEGIKTLYDNVD 478
GL G ++ P+G + Y + A LRK FDL+ANVRP +S GI L+D++D
Sbjct: 67 E----GLDGWILGPIGHRDYPKVPGAINPHPILRKGFDLFANVRPTRSYPGIGCLFDDID 122
Query: 479 VVTIRENTEGEY--------SGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRK 634
+V +REN EG SG E + V S+++IT E +V A AR RK
Sbjct: 123 LVIVRENNEGFQPDRNVVAGSG-EFRPTEDVTISVRVITVEGCRKVVRAALDIARSRPRK 181
Query: 635 KVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPN 814
K+T VHK + ++ G+F+ E+A +YPD++ + + T + +++DP +D +V N
Sbjct: 182 KLTLVHKNTVFKLGCGMFVDTAYEVAKEYPDVEVDECIVDTFAMRLLRDPWAYDTVVTTN 241
Query: 815 LYGDIMSDMCSGL 853
++GDI++D +G+
Sbjct: 242 MFGDILTDEAAGM 254
>UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Methanosaeta thermophila PT|Rep: Isocitrate
dehydrogenase (NAD(+)) - Methanosaeta thermophila
(strain DSM 6194 / PT) (Methanothrixthermophila (strain
DSM 6194 / PT))
Length = 375
Score = 129 bits (311), Expect = 1e-28
Identities = 81/241 (33%), Positives = 128/241 (53%), Gaps = 16/241 (6%)
Frame = +2
Query: 164 IPGHGIGPEIT-VAVQKIFEAAKVPIEWEEVDVTAVRGPD------GKFGIPQKAIDSVN 322
+ G GIGP IT A++ + + +E +V+ + G +P A+D++
Sbjct: 21 VDGDGIGPYITGEAIRVLQSLLRDELERGDVEFRKIEGLSIEERARAMKALPDDALDALK 80
Query: 323 ANKIGLKGPLMTPVGKG-----YRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVT 487
+ LKGPL TP KG S N+A+R+E DL+ANVRP + + +D V
Sbjct: 81 KCHVILKGPLTTPK-KGDPWPNLESANVAMRRELDLFANVRP------VSIPSEGIDWVF 133
Query: 488 IRENTEGEY--SGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKAN 661
RENTEGEY + D + K+IT + S R+ AF +AR N +V+ V KAN
Sbjct: 134 FRENTEGEYVLGSKGFNVTDDLAVDFKVITTQGSERIIRLAFDYARRNNINRVSVVTKAN 193
Query: 662 IMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSK--FDVLVMPNLYGDIMS 835
+++ + G FL R ++ +YP+I F+ ++ + +V + F V+V+PNLYGDI++
Sbjct: 194 VVKTTDGKFLEIARAISKEYPEITFDDWFVDIMAAKLVDTKRRRDFRVIVLPNLYGDILT 253
Query: 836 D 838
D
Sbjct: 254 D 254
>UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Chloroflexi (class)|Rep: 3-isopropylmalate dehydrogenase
- Roseiflexus sp. RS-1
Length = 362
Score = 128 bits (310), Expect = 1e-28
Identities = 83/244 (34%), Positives = 120/244 (49%), Gaps = 15/244 (6%)
Frame = +2
Query: 155 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKI 334
+ +IPG GIG E+ A + A +P +E D +P + + A
Sbjct: 8 ILVIPGDGIGREVIPAAVAVLRATGLPFHFENADAGWECFQRQGEALPSATLTAARAADA 67
Query: 335 GLKGPLMTP--VGKGYRSLNLALRKEFDLYANVRPCKS---LEGIKTLYDNVDVVTIREN 499
L G + +P GYRS + LR+E DLYAN+RP G VD+V +REN
Sbjct: 68 ILFGAVASPGYPVAGYRSPIVRLRRELDLYANIRPVFDDLPENGSNPRRRKVDLVVVREN 127
Query: 500 TEGEYSGIEHEIVDGVVQ-SIKLITEEASTRVAEFAFQFARENKRKK---------VTAV 649
TE Y+G E DG + ++IT AS R+ A AR + + VT V
Sbjct: 128 TEDVYAGRERVEDDGATAIAERVITRRASARIMRVACDLARARRSARNGSDAPPGRVTVV 187
Query: 650 HKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDI 829
HKAN++R + GLF E+A YPD++ + + T L + P +FDV+V NL+GDI
Sbjct: 188 HKANVLRETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQLATRPERFDVIVTTNLFGDI 247
Query: 830 MSDM 841
+SD+
Sbjct: 248 LSDV 251
>UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase,
mitochondrial precursor; n=33; Dikarya|Rep:
Homoisocitrate dehydrogenase, mitochondrial precursor -
Saccharomyces cerevisiae (Baker's yeast)
Length = 371
Score = 126 bits (303), Expect = 9e-28
Identities = 94/273 (34%), Positives = 144/273 (52%), Gaps = 25/273 (9%)
Frame = +2
Query: 110 ATRAGAAQ--YSTGVRK---VTLIPGHGIGPEITVAVQKIFEA--AKVPIEWEEVDVTAV 268
ATR A + S RK + LIPG GIG E+ A +++ E +K + + +D+ A
Sbjct: 6 ATRLSACRGLASNAARKSLTIGLIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFIDLYAG 65
Query: 269 RGPDGKFG--IPQKAIDSVNANKIG-LKGPLMTPVGK--GYRSLNLALRKEFDLYANVRP 433
+ G +P + + + G L G + +P K GY S +ALR+E L+ANVRP
Sbjct: 66 FQTFQETGKALPDETVKVLKEQCQGALFGAVQSPTTKVEGYSSPIVALRREMGLFANVRP 125
Query: 434 CKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDG-----VVQSIKLITEEASTRVAE 598
KS+EG K +D+V +RENTE Y IE +D V + K I+E A+ R+A
Sbjct: 126 VKSVEGEKG--KPIDMVIVRENTEDLYIKIEKTYIDKATGTRVADATKRISEIATRRIAT 183
Query: 599 FAFQFARENKRKK----VTAVHKANIMRMSXGLFLRCCREL----ATKYPDIKFEXRYLX 754
A A + + + +T HK+N++ S GLF C+E+ KY IK+ + +
Sbjct: 184 IALDIALKRLQTRGQATLTVTHKSNVLSQSDGLFREICKEVYESNKDKYGQIKYNEQIVD 243
Query: 755 TVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGL 853
++ + ++P FDV+V PNLYGDI+SD + L
Sbjct: 244 SMVYRLFREPQCFDVIVAPNLYGDILSDGAAAL 276
>UniRef50_Q8FPV5 Cluster: 3-isopropylmalate dehydrogenase; n=50;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Corynebacterium efficiens
Length = 340
Score = 125 bits (302), Expect = 1e-27
Identities = 80/242 (33%), Positives = 129/242 (53%), Gaps = 13/242 (5%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRG-PDGKFGIPQ-----KAID 313
K+ +I G GIGPE+T K+ A + IE ++D+ A R +G+ + + D
Sbjct: 2 KLAVIGGDGIGPEVTDEALKVLRALRADIETTDLDLGARRYLRNGELLTDEDLALLREHD 61
Query: 314 SVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN---VDVV 484
++ IG G + P G R L L LR D + N+RP K EG+++ N +D V
Sbjct: 62 AILLGAIGAPGSV--PPGVLERGLLLKLRFALDHHVNLRPSKLYEGVESPLKNPGEIDFV 119
Query: 485 TIRENTEGEYSGIEHEIVDGV----VQSIKLITEEASTRVAEFAFQFARENKRKKVTAVH 652
+RE TEG Y+G I G + T + RV +AF+ A +++R+ +T VH
Sbjct: 120 VVREGTEGAYTGNGGAIRVGTPHETANETSVNTRYGAERVIRYAFELA-QSRRRHLTLVH 178
Query: 653 KANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIM 832
K N++ GL+ R E+A +YP++ + ++ + +V DPS+FDV+V NL+GDI+
Sbjct: 179 KTNVLVHGGGLWQRTVDEVAREYPEVTVDYNHIDAATIYLVTDPSRFDVIVTDNLFGDIL 238
Query: 833 SD 838
+D
Sbjct: 239 TD 240
>UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]
subunit-like 4 (Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4); n=1; Arabidopsis thaliana|Rep:
Putative isocitrate dehydrogenase [NAD] subunit-like 4
(Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4) - Arabidopsis thaliana
(Mouse-ear cress)
Length = 294
Score = 125 bits (302), Expect = 1e-27
Identities = 69/188 (36%), Positives = 115/188 (61%), Gaps = 2/188 (1%)
Frame = +2
Query: 179 IGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMT 358
I +T AV ++ +A + P+ +E ++G + + + +DS+ NK+ L G +
Sbjct: 8 IDSNVTNAVHQVMDAMQAPVYFETY---IIKGKNMNH-LTWEVVDSIRKNKVCLNGRVNN 63
Query: 359 PVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIV 538
+ G RKE DL+A++ C +L G + ++NVD+V IRENTEGEY+G EHE+V
Sbjct: 64 SLCGG-------ARKELDLFASLVDCFNLNGQPSRHENVDIVVIRENTEGEYAGREHEVV 116
Query: 539 DGVVQSIKL-ITEEASTRVAEFAFQFARENKRKKVTAVH-KANIMRMSXGLFLRCCRELA 712
GV++S ++ +T+ S R+A++AF++A +KRKKVTAVH +++ FL C+E+A
Sbjct: 117 PGVIESFQVTMTKFWSDRIAKYAFEYAHFSKRKKVTAVHNNGKYEKLADAFFLESCQEVA 176
Query: 713 TKYPDIKF 736
YP+I +
Sbjct: 177 KMYPNITY 184
>UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Proteobacteria|Rep: 3-isopropylmalate dehydrogenase -
Bradyrhizobium japonicum
Length = 365
Score = 124 bits (298), Expect = 4e-27
Identities = 85/260 (32%), Positives = 137/260 (52%), Gaps = 15/260 (5%)
Frame = +2
Query: 119 AGAAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWE-EVDVTAVRGPDGK-FG 292
A A Q+ V ++ ++PG GIGPEIT A + AA + ++ AV K FG
Sbjct: 3 APALQFWGNVMQLIVLPGDGIGPEITTATSGVLRAASERFQLNLRLEEHAVGHASLKQFG 62
Query: 293 --IPQKAIDSVNANKIGLKGPLMTPVGK--GYRSLNLA--LRKEFDLYANVRPCKSLEGI 454
+ + +D V + GP T K + +N + RK DLYANVRP ++ G
Sbjct: 63 TTVRPELLDIVRGADGLILGPTATFDFKDEAHGEINPSRHFRKNLDLYANVRPARTYAGR 122
Query: 455 KTLYDNVDVVTIRENTEGEYSGIEHEIVDG-------VVQSIKLITEEASTRVAEFAFQF 613
+ D+V +RENTEG Y+ E +G V S++ IT R+A A +
Sbjct: 123 PGRLGDFDLVVVRENTEGFYADRNMEQGNGEMLVTPDVAISLRRITRACCERIAHAACRL 182
Query: 614 ARENKRKKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKF 793
A + +R+ +T VHKAN++++ G+FL CR A Y ++ + + + ++V++P +F
Sbjct: 183 AMK-RRRHLTIVHKANVLKIGDGMFLDICRAAAKGYAGLEVDDILVDAMMAHVVRNPDRF 241
Query: 794 DVLVMPNLYGDIMSDMCSGL 853
DV+V N++GDI+SD+ + L
Sbjct: 242 DVIVATNMFGDILSDLTAEL 261
>UniRef50_A1SM34 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Nocardioides sp. JS614|Rep: 3-isopropylmalate
dehydrogenase - Nocardioides sp. (strain BAA-499 /
JS614)
Length = 478
Score = 123 bits (297), Expect = 5e-27
Identities = 78/256 (30%), Positives = 128/256 (50%), Gaps = 17/256 (6%)
Frame = +2
Query: 137 STGVRKVTLIPGHGIGPEITVAVQKIFEAAK---VPIEWEEVDVTAVRGPDGKFGIPQKA 307
++G ++ +IPG GIGPE+T K+ E A V E D+ A R +P
Sbjct: 128 TSGSLRLAVIPGDGIGPEVTAEALKVLEVASPAGVKFEQTRYDLGAERYLATGEVLPDSV 187
Query: 308 IDSVNANKIGLKGPL-------MTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY 466
++ + + L G + P G R L L LR E D Y N+RP + G+ +
Sbjct: 188 LEEIREHDAILLGAVGGKPNDPNLPPGILERGLLLRLRFELDHYVNLRPSRIFPGVASPL 247
Query: 467 DN---VDVVTIRENTEGEYSGIEHEIVDG----VVQSIKLITEEASTRVAEFAFQFAREN 625
N VD V +RE TEG Y+G + G + + + T RV AF A+
Sbjct: 248 ANPGEVDFVVVREGTEGPYTGNGGALRVGTPHEIATEVSVNTAFGVERVVRDAFARAQRR 307
Query: 626 KRKKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLV 805
RKK+T VHK N++ + ++ R +++A +YP++ + ++ + M DP++FDV+V
Sbjct: 308 PRKKLTLVHKTNVLVNAGAVWWRITQQVAAEYPEVSVDYMHIDAAMIFMTTDPARFDVIV 367
Query: 806 MPNLYGDIMSDMCSGL 853
NL+GDI++D+ + +
Sbjct: 368 TDNLFGDIITDLAAAI 383
>UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;
n=4; cellular organisms|Rep: LeuB-1 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 354
Score = 120 bits (290), Expect = 4e-26
Identities = 79/244 (32%), Positives = 128/244 (52%), Gaps = 14/244 (5%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITV----AVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSV 319
++ +IPG GIG E+ ++K+ E ++V E++E A +P AI+
Sbjct: 4 RIAVIPGDGIGKEVVAEGLKVLKKLEELSRVSFEFKEYPFGAEHYLKTGETLPDWAIEEF 63
Query: 320 ---NANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY---DNVDV 481
+A G G G R + L +R E DLY N+RP K T + +D+
Sbjct: 64 KKFDAIYFGAIGDPRVKPGILERGILLKMRFELDLYVNLRPVKLYHPRLTPLKGKNKIDI 123
Query: 482 VTIRENTEGEYSGIEHEIVDGVVQSIK----LITEEASTRVAEFAFQFARENKRKKVTAV 649
V +RENTEG Y+G + G Q I + T RV FAF++A+ + RKKVT V
Sbjct: 124 VFVRENTEGLYAGAGGFLRKGTPQEIAVQEMINTRFGVERVIRFAFEYAKRSGRKKVTLV 183
Query: 650 HKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDI 829
KAN++ + L+ R E++ +Y D++ + Y+ + + M++ P FDV+V PN++GDI
Sbjct: 184 DKANVLTYAHDLWERVFAEVSQEY-DLETDHYYVDAMAMKMIRSPESFDVVVTPNMFGDI 242
Query: 830 MSDM 841
++D+
Sbjct: 243 LTDL 246
>UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Thermoproteaceae|Rep: 3-isopropylmalate dehydrogenase -
Pyrobaculum aerophilum
Length = 290
Score = 119 bits (286), Expect = 1e-25
Identities = 66/191 (34%), Positives = 118/191 (61%), Gaps = 3/191 (1%)
Frame = +2
Query: 284 KFG--IPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIK 457
K+G +PQ+A+ +A + KGP +G+ + +R + LYAN+RP K+L G+
Sbjct: 15 KYGTAMPQEALRLADAADVIFKGP----IGESAYDVTSLIRMRYTLYANIRPVKNLPGVP 70
Query: 458 TLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKK 637
+ + +D V +REN E Y G E+++ D V ++K+ITE+ + RVA A ++A E +R++
Sbjct: 71 AVRE-IDCVFVRENVEDVYVGAEYKVGD-VAIALKVITEKGTRRVARMARKYA-EMRRRR 127
Query: 638 VTAVHKANIMRMSXGLFLRCCRELATK-YPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPN 814
VT VHKAN++R+ G F R++A + ++ + Y+ + +V++P +FDV++ N
Sbjct: 128 VTIVHKANVLRVVDGFF----RDIALEELKGLEVDQMYVDAAAMELVRNPKRFDVVLTMN 183
Query: 815 LYGDIMSDMCS 847
YGDI++D+ +
Sbjct: 184 QYGDILTDLAA 194
>UniRef50_Q8XSY8 Cluster: Probable 3-isopropylmalate dehydrogenase
oxidoreductase protein; n=1; Ralstonia solanacearum|Rep:
Probable 3-isopropylmalate dehydrogenase oxidoreductase
protein - Ralstonia solanacearum (Pseudomonas
solanacearum)
Length = 365
Score = 118 bits (283), Expect = 2e-25
Identities = 82/253 (32%), Positives = 134/253 (52%), Gaps = 19/253 (7%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAAK------VPIEWEEVDVTAVR--GPDGKFGIPQKA 307
++ ++P GIGPEI A ++ +A + ++++V T++ G + + KA
Sbjct: 2 RILVLPCDGIGPEIVGAAMEVLRSADSVFKLDLAFDYDDVGFTSLEKYGTTLRDEVLAKA 61
Query: 308 IDSVNANKIGLKGPLMTPV-GKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN---V 475
+ + +G + P KG R+++ R DLYANVRP ++ + + +
Sbjct: 62 -KTYDGVILGTQSHADYPAPDKGGRNVSAGFRIGLDLYANVRPARTRPFLTSNMREGRTM 120
Query: 476 DVVTIRENTEGEYSGIEH-----EIVDGVVQSIKL--ITEEASTRVAEFAFQFARENKRK 634
D+V +RE TEG Y E++ +I L IT S R+A AF+ A + K K
Sbjct: 121 DLVIMREATEGFYPDRNMTKGWAELMPSPDMAISLRKITRHCSERIARRAFELAMKRK-K 179
Query: 635 KVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPN 814
KVTA+HKAN M+ GLFL C R++A +P+++ + + ++V+ P +FDVLV N
Sbjct: 180 KVTAIHKANSFHMTDGLFLECVRDVARDFPEVRLDDLLIDASTAHLVRAPERFDVLVATN 239
Query: 815 LYGDIMSDMCSGL 853
YGDI+SD+ S L
Sbjct: 240 FYGDIISDLASEL 252
>UniRef50_Q8U299 Cluster: 3-isopropylmalate dehydrogenase 2; n=3;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
2 - Pyrococcus furiosus
Length = 355
Score = 116 bits (279), Expect = 8e-25
Identities = 76/244 (31%), Positives = 124/244 (50%), Gaps = 14/244 (5%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITV----AVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSV 319
K+ +IPG GIG E+ ++KI E + V +++E A +P A++
Sbjct: 3 KIAVIPGDGIGKEVVAEGLKVLRKIEELSNVKFDFQEYPFGAEHYLKTGETLPDWALEEF 62
Query: 320 ---NANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY---DNVDV 481
+A G G G + L LR DLY N+RP K T + +D+
Sbjct: 63 RHFDAIYFGAIGDPRVKPGILEHGILLKLRFSLDLYVNLRPVKLYHPKLTPLKGKEKIDM 122
Query: 482 VTIRENTEGEYSGIEHEIVDGVVQSIKLI----TEEASTRVAEFAFQFARENKRKKVTAV 649
V IRENTEG Y+G + G + + T R FAF++A+ RKKVT V
Sbjct: 123 VFIRENTEGLYAGAGGFLRKGTPHEVAIQEMINTRFGVERTIRFAFEYAKTKGRKKVTLV 182
Query: 650 HKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDI 829
KAN++ + L+ R +E+A++Y +I+ + Y+ + + M++ P F+V+V PN++GDI
Sbjct: 183 DKANVLTYAHDLWQRVFKEVASEYQEIETDHYYVDAMAMKMIRSPEIFEVVVTPNMFGDI 242
Query: 830 MSDM 841
++D+
Sbjct: 243 LTDL 246
>UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=2; Archaea|Rep: Isocitrate dehydrogenase,
NADP-dependent - Halorubrum lacusprofundi ATCC 49239
Length = 463
Score = 116 bits (279), Expect = 8e-25
Identities = 77/208 (37%), Positives = 107/208 (51%), Gaps = 30/208 (14%)
Frame = +2
Query: 155 VTLIPGHGIGPEITVAVQKIFEAAKVP----IEWEEVDVTAVRGPDGKFGIPQKAIDSVN 322
+ +I G GIG ++ A QK+ +AA I W V +P+ + ++
Sbjct: 76 IPIIHGDGIGTDVGPAAQKVLDAAAEATGRSIAWMRVYAGGSARDMYDENLPEDTVSAIR 135
Query: 323 ANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN---VDVVTIR 493
+++ +KGPL TPVG G+RSLN+ALRK DLYANVRP L+G+ + N +D++T R
Sbjct: 136 DHRVAIKGPLTTPVGAGFRSLNVALRKTLDLYANVRPTYYLDGVPSPVKNPEKMDMITFR 195
Query: 494 ENTEGEYSGIEHE----------------------IVDGVVQ-SIKLITEEASTRVAEFA 604
ENTE Y+GIE E I DG V +K I+E S R+ A
Sbjct: 196 ENTEDVYAGIEWEAGTDEVEQVRDFLEDDMEIADVIHDGPVGIGVKPISEFGSKRLIREA 255
Query: 605 FQFARENKRKKVTAVHKANIMRMSXGLF 688
+A N R VT VHK NIM+ + G F
Sbjct: 256 IDYALANDRDSVTLVHKGNIMKFTEGAF 283
>UniRef50_Q0X0C1 Cluster: Putative dehydrogenase; n=1; Streptomyces
lasaliensis|Rep: Putative dehydrogenase - Streptomyces
lasaliensis
Length = 362
Score = 115 bits (276), Expect = 2e-24
Identities = 86/260 (33%), Positives = 119/260 (45%), Gaps = 13/260 (5%)
Frame = +2
Query: 113 TRAGAAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDV----TAVRGPD 280
T + A T V + +IPG GIGPE+ + +A + + +D T +R +
Sbjct: 8 TCSARAGSETAVTTIAVIPGDGIGPEVIEPALDVLDALGLGTRTDILDHVNADTYLRTGE 67
Query: 281 GKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSL-EGIK 457
G I S A +G G R + LR E DLY N RP + + +
Sbjct: 68 ALTGSDLDRIRSSEAALLGAVGDPRLGDTSYVRGVLTTLRLELDLYVNYRPARLWHDRLS 127
Query: 458 TLYDN----VDVVTIRENTEGEYSGIEHEIVDG----VVQSIKLITEEASTRVAEFAFQF 613
L D +D V +RENTEG YSGI G + + L T +RV EFAF
Sbjct: 128 PLRDPARRAIDCVIVRENTEGLYSGIGGGARTGTPEEIAVDVDLSTRHGVSRVLEFAFSA 187
Query: 614 ARENKRKKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKF 793
A R+ V V KAN +R L+ RC E ++P I Y+ T L + DP+ F
Sbjct: 188 A----RRSVCLVDKANAVRNGGQLWQRCWGEAVARHPHIATSHLYVDTAALRLATDPTGF 243
Query: 794 DVLVMPNLYGDIMSDMCSGL 853
DV+V N YGDI+SD+ + L
Sbjct: 244 DVIVTNNSYGDILSDLTAAL 263
>UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1;
Entamoeba histolytica HM-1:IMSS|Rep: tartrate
dehydrogenase - Entamoeba histolytica HM-1:IMSS
Length = 370
Score = 114 bits (274), Expect = 3e-24
Identities = 77/238 (32%), Positives = 120/238 (50%), Gaps = 8/238 (3%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 331
K+ +IPG GIG E+ +K+F++ +PI+ + VD +P ID V
Sbjct: 12 KIIVIPGDGIGAEVMNEAEKMFQSLNLPIQRDYVDWGIQHYLKTGKVVPIDYIDQVKQYD 71
Query: 332 IGLKGPLMTP-VGKGYRSLN--LALRKEFDLYANVRPCKSLEGIKTLYDN--VDVVTIRE 496
L G L P Y +L + +R++ D + +RP K GI T +DV+ +RE
Sbjct: 72 AILLGSLGDPRTLPDYVTLEPLIQMRQQLDQFLCLRPAKHFPGIPTPLKKCEIDVLVVRE 131
Query: 497 NTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKK---VTAVHKANIM 667
N+EGEYS I G + + + S R E ++A E RK+ VT K+N M
Sbjct: 132 NSEGEYSNIGGIFKSGTPEEFAIESAVHSRRGLERVIRYAFEASRKRRNHVTLATKSNAM 191
Query: 668 RMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDM 841
+ L+ +A +YPD+ E Y+ + +V++PSKFDV+V NL+ DI+SD+
Sbjct: 192 KFGMVLWDSVFEAIAMEYPDVTAEKYYMDALSAEIVKNPSKFDVIVGSNLFCDIISDL 249
>UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular
organisms|Rep: Tartrate dehydrogenase - Burkholderia
mallei (Pseudomonas mallei)
Length = 361
Score = 113 bits (273), Expect = 4e-24
Identities = 82/263 (31%), Positives = 132/263 (50%), Gaps = 25/263 (9%)
Frame = +2
Query: 137 STGVRKVTLIPGHGIGPEITV-------AVQKIF--EAAKVPIEWEEVDVTAVRG---PD 280
S V ++ +IPG GIG E+ AV + F A PIEW D A G PD
Sbjct: 2 SEKVYRIAVIPGDGIGVEVMPEGLRALDAVSRRFGLRFAYEPIEWASCDYYAKHGQMMPD 61
Query: 281 GKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKT 460
+ +D++ +G P P + R+EFD Y N+RP + +G+
Sbjct: 62 D-WKTQLSGMDALLFGAVGW--PETVPDHISLWGSLIKFRREFDQYVNLRPARLFDGVPC 118
Query: 461 LY-----DNVDVVTIRENTEGEYSGIEHEIVDG-----VVQSIKLITEEASTRVAEFAFQ 610
++D + +RENTEGEYS + + +G VVQ + T + RV +FAF+
Sbjct: 119 PLAGRKAGDIDFMIVRENTEGEYSAVGGTMFEGTEREFVVQQA-VFTRHGTERVLKFAFE 177
Query: 611 FARENKRKKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSK 790
A + + K++T K+N + +S + E+A +YPD+ ++ +++ +C V P +
Sbjct: 178 LA-QRRAKRLTVATKSNGIAISMPWWDARAAEMAARYPDVTWDKQHIDILCARFVMQPDR 236
Query: 791 FDVLVMPNLYGDIMSDM---CSG 850
FDV+V NL+GDI+SD+ C+G
Sbjct: 237 FDVVVASNLFGDILSDLGPACTG 259
>UniRef50_O29610 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=15; Archaea|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Archaeoglobus fulgidus
Length = 412
Score = 113 bits (272), Expect = 5e-24
Identities = 102/306 (33%), Positives = 145/306 (47%), Gaps = 54/306 (17%)
Frame = +2
Query: 98 KIVPATRAGAAQYSTG---VRKVTLIP---GHGIGPEITVAVQKIFEAAKVPIEWEEVDV 259
K+ P +Y G V +IP G GIG ++ A ++ +AA I E V
Sbjct: 5 KVKPPENGEKIRYENGKLIVPDNPIIPYFEGDGIGKDVVPAAIRVLDAAADKIGKEVVWF 64
Query: 260 TAVRGPDGK--FG--IPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANV 427
G D +G +P ++++ ++ LKGPL TPVG GYRSLN+ +R+ DLYANV
Sbjct: 65 QVYAGEDAYKLYGNYLPDDTLNAIKEFRVALKGPLTTPVGGGYRSLNVTIRQVLDLYANV 124
Query: 428 RPCKSLEGIKTLY---DNVDVVTIRENTEGEYSGIE-----HEIVD---------GVV-- 550
RP L+G+ + + V+ V RENTE Y+GIE E + GV
Sbjct: 125 RPVYYLKGVPSPIKHPEKVNFVIFRENTEDVYAGIEWPRGSEEALKLIRFLKNEFGVTIR 184
Query: 551 ----QSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSXGLFL--------- 691
IK I+E A+ R+ A ++A EN RK VT VHK NIM+ + G F
Sbjct: 185 EDSGIGIKPISEFATKRLVRMAIRYAIENNRKSVTLVHKGNIMKYTEGAFRDWGYEVAKQ 244
Query: 692 ---RCC---RELATKYPDIKFEXRYL--XTVCLNMVQD----PSKFDVLVMPNLYGDIMS 835
C EL KY + E + + + NM Q ++DV+ +PNL GD +S
Sbjct: 245 EFGEYCITEDELWDKYGGKQPEGKIVVKDRIADNMFQQILTRTDEYDVIALPNLNGDYLS 304
Query: 836 DMCSGL 853
D + L
Sbjct: 305 DAAAAL 310
>UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep: Isocitrate
dehydrogenase (NAD(+)) - Candidatus Nitrosopumilus
maritimus SCM1
Length = 343
Score = 112 bits (270), Expect = 9e-24
Identities = 76/242 (31%), Positives = 126/242 (52%), Gaps = 7/242 (2%)
Frame = +2
Query: 149 RKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVR----GPDGKFGIPQKAIDS 316
+K ++ G GIGPE+ ++ ++ + E + + + G IP +
Sbjct: 3 KKAAVMKGDGIGPEVVDSMLRVLKECNFQSELILCEAGSEQWDKNGRKDASYIPDVTMKI 62
Query: 317 VNANKIGLKGPLMT-PVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIR 493
+ KGP T PV RS+ + LR++FDLYAN+RP K+ + + T +D V R
Sbjct: 63 LEETDCCFKGPTTTIPVPGAPRSVAVTLRQKFDLYANIRPTKTYDRL-TPDRKLDCVCFR 121
Query: 494 ENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRM 673
E TEG Y+G+E +I D +I+ IT + S R+ + A +A + KK+ AV K NI++
Sbjct: 122 EATEGLYTGVEAKITDDAAIAIRKITRQGSRRLIDSAVDWANKFNMKKMVAVTKRNILKQ 181
Query: 674 SXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFD--VLVMPNLYGDIMSDMCS 847
+ G+F ++ A + DI+ Y+ + MV +F+ VLV NL+ DI+S++ S
Sbjct: 182 TDGIFWDETQK-AVEGTDIELSEIYIDNMAQQMVIATEQFNGAVLVSTNLFMDIISELAS 240
Query: 848 GL 853
L
Sbjct: 241 AL 242
>UniRef50_Q6L2P9 Cluster: Isocitrate dehydrogenase [NADP]; n=2;
Thermoplasmatales|Rep: Isocitrate dehydrogenase [NADP] -
Picrophilus torridus
Length = 392
Score = 112 bits (269), Expect = 1e-23
Identities = 82/266 (30%), Positives = 134/266 (50%), Gaps = 38/266 (14%)
Frame = +2
Query: 170 GHGIGPEITVAVQKIFEAA----KVPIEWEEVDVTAVRGPDGKFG-IPQKAIDSVNANKI 334
G GIGPEI A +K+ +AA K I W+E+ + R + K P+++I ++N ++
Sbjct: 24 GDGIGPEIMDATRKVVDAATAMEKKSIAWKEI-LLGDRAEELKGDRFPEESIKAINDYRV 82
Query: 335 GLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN---VDVVTIRENTE 505
LK PL TPVGKG++S+N+ +R DLYAN+RP K + G+++ N V++ RENT+
Sbjct: 83 LLKAPLNTPVGKGFKSINVRIRMLLDLYANIRPVKFMPGLESPLKNPEKVNLTIFRENTD 142
Query: 506 GEYSGIEH--------------------EIVDGVVQSIKLITEEASTRVAEFAFQFAREN 625
Y G E +I D IK ++ + R+ A ++A +N
Sbjct: 143 DLYLGYEWSYDTDEAKRIRKFLKDEFNIDISDDSGIGIKPMSRYKTQRITRLAVKYAMDN 202
Query: 626 KRKKVTAVHKANIMRMSXGLFLRCCRELA----TKYPDIKFEXRYLXT--VCLNMVQD-- 781
KK+T +HK N+M+ + G F E A + Y + + + + NM Q
Sbjct: 203 NLKKITIMHKGNVMKYTEGAFREWAYETALNEFSDYVSRDDDKKIIINDIIADNMFQQII 262
Query: 782 --PSKFDVLVMPNLYGDIMSDMCSGL 853
P ++ +++ PN+ GD +SD L
Sbjct: 263 TRPDEYQLILAPNVDGDYISDAAGAL 288
>UniRef50_Q5HNL1 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=73; cellular organisms|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Staphylococcus epidermidis (strain ATCC 35984 /
RP62A)
Length = 422
Score = 111 bits (267), Expect = 2e-23
Identities = 75/219 (34%), Positives = 117/219 (53%), Gaps = 33/219 (15%)
Frame = +2
Query: 155 VTLIPGHGIGPEITVAVQKIFEAA-------KVPIEWEEVDVTAVRGPDGKFGIPQKAID 313
+ I G GIGP+I A ++ +AA + IEW+EV + +PQ+ ++
Sbjct: 21 IPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAYDETGEWLPQETLE 80
Query: 314 SVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY---DNVDVV 484
++ I +KGPL TP+G G RSLN+ALR+E DL+ +RP + +G+ + ++VD+V
Sbjct: 81 TIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPEDVDMV 140
Query: 485 TIRENTEGEYSGIE--------HEIVD------GVVQ---------SIKLITEEASTRVA 595
RENTE Y+GIE +++D G IK +++E + R+
Sbjct: 141 IFRENTEDIYAGIEFKQGTSEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLV 200
Query: 596 EFAFQFARENKRKKVTAVHKANIMRMSXGLFLRCCRELA 712
A Q+A +N RK VT VHK NIM+ + G F + +LA
Sbjct: 201 RAAIQYALDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLA 239
>UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for
NADP+; n=3; Alteromonadales|Rep: Isocitrate
dehydrogenase, specific for NADP+ - Alteromonadales
bacterium TW-7
Length = 422
Score = 110 bits (264), Expect = 5e-23
Identities = 93/285 (32%), Positives = 141/285 (49%), Gaps = 54/285 (18%)
Frame = +2
Query: 155 VTLIPGHGIGPEITVAVQKIFEAA-------KVPIEWEEV--DVTAVRGPDGKFGIPQKA 307
+ I G G+G ++ ++ I + A K I W +V A + DG + PQ+
Sbjct: 31 IAYINGDGVGQDVMPVMRNIVDCAIKHCYKNKRKIHWMQVFNGEQAAKLYDGDW-FPQET 89
Query: 308 IDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN---VD 478
I +V A KI +KGPL TP+G G+RSLN+ALR+E DL+ N+R K + + N +
Sbjct: 90 IQAVRACKIAIKGPLTTPLGGGFRSLNVALRQEMDLFVNMRTIKGFSALPSPLKNPFLTN 149
Query: 479 VVTIRENTEGEYSGIE--------HEIVD------GVVQ---------SIKLITEEASTR 589
+ +R+++E YSGIE +++D GV + IK I++E S R
Sbjct: 150 ITVLRDSSEDVYSGIEWQAGSIESEKMLDFLCEEMGVTRLRFSQDCGIGIKNISKEGSER 209
Query: 590 VAEFAFQFARENKRKKVTAVHKANIMRMSXGLFLRCCRELATK-YPDIKFE-XRYL---- 751
+ FA FA N R VT VHK N+++ + G F R LA K + I+ E R+L
Sbjct: 210 LTRFALNFALNNNRDSVTFVHKGNVLKFTDGAFKRWGFALAKKEFNAIEHENGRWLKIER 269
Query: 752 ---------XTVCLNMVQ----DPSKFDVLVMPNLYGDIMSDMCS 847
+ NM+Q +P +FDV+ N GD ++DM S
Sbjct: 270 AGQAPLIIKEVIADNMLQQCLMNPEQFDVVATTNQNGDFLADMLS 314
>UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421,
highly similar to PROTEIN KINASE C-BINDING PROTEIN
NELL1; n=2; Homo sapiens|Rep: CDNA FLJ36019 fis, clone
TESTI2016421, highly similar to PROTEIN KINASE C-BINDING
PROTEIN NELL1 - Homo sapiens (Human)
Length = 355
Score = 109 bits (263), Expect = 7e-23
Identities = 50/102 (49%), Positives = 72/102 (70%)
Frame = +2
Query: 395 LRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITE 574
L DLYA+V K+L ++T + +VD++ + ENTEGEYS +EHE V GV +S+K++T+
Sbjct: 2 LHTTLDLYASVIHLKNLPNVETWHKDVDILVVWENTEGEYSNLEHESVKGVTESLKIMTK 61
Query: 575 EASTRVAEFAFQFARENKRKKVTAVHKANIMRMSXGLFLRCC 700
S R+AE+AFQ A++ KKV AVHK NI ++ G FL+CC
Sbjct: 62 AKSLRIAEYAFQLAQKMGCKKVMAVHKVNITKLGDGPFLQCC 103
>UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8; n=1; Pan
troglodytes|Rep: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8 - Pan troglodytes
Length = 331
Score = 109 bits (262), Expect = 9e-23
Identities = 56/135 (41%), Positives = 90/135 (66%), Gaps = 2/135 (1%)
Frame = +2
Query: 155 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKI 334
VT++PG G+GPE+ AV+++F+AA VP+E++E ++ V+ + + Q + S+ NK+
Sbjct: 51 VTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQ-VLSSMKENKV 109
Query: 335 GLKGPLMTPVG-KG-YRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEG 508
+ G + TP+ KG S ++ LR++ DL+ANV KSL G T ++N+D+V IRE TEG
Sbjct: 110 AIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEG 169
Query: 509 EYSGIEHEIVDGVVQ 553
EYS +EHE + V +
Sbjct: 170 EYSSLEHECCEEVAE 184
Score = 70.1 bits (164), Expect = 6e-11
Identities = 28/53 (52%), Positives = 39/53 (73%)
Frame = +2
Query: 695 CCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGL 853
CC E+A YP IKFE + C+ +VQ+P +FDVLVMPNLYG+I+ ++ +GL
Sbjct: 178 CCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGL 230
>UniRef50_A7GLU7 Cluster: Tartrate dehydrogenase; n=3; Bacteria|Rep:
Tartrate dehydrogenase - Bacillus cereus subsp.
cytotoxis NVH 391-98
Length = 364
Score = 107 bits (258), Expect = 3e-22
Identities = 75/254 (29%), Positives = 131/254 (51%), Gaps = 20/254 (7%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVT------AVRGPDGKF----GIPQ 301
KV +I G GIGPE+ K+ + + + + T GK GI Q
Sbjct: 5 KVAVIAGDGIGPEVMDEGVKVLQTIANVSQQFKFEFTYFPWGCEFYSKHGKMMDDDGIEQ 64
Query: 302 -KAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEG----IKTLY 466
KA D++ +G G P L L +R+ FD Y N+RP L+G +K +
Sbjct: 65 LKAFDAIYLGAVGFPG---VPDYISLWDLLLRIRQSFDQYVNIRPVTLLKGAPCPLKDVK 121
Query: 467 -DNVDVVTIRENTEGEYSGIEHEIVDG----VVQSIKLITEEASTRVAEFAFQFARENKR 631
+++D++ IREN+EGEY+G + G VV + + + + R+ +AF+ AR+ +R
Sbjct: 122 REDIDMLFIRENSEGEYAGAGDWLYKGKEHEVVLQNSVFSRKGTERIIRYAFEIARK-ER 180
Query: 632 KKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMP 811
K +T++ K N + S + + E++ +YPD+K + + M+++P +F+V+V
Sbjct: 181 KSLTSISKGNALNYSMVFWDQIFEEISKEYPDVKTASYLVDAAAMLMIKEPHRFEVVVTS 240
Query: 812 NLYGDIMSDMCSGL 853
NL+GDI++D+ + L
Sbjct: 241 NLFGDILTDLGAAL 254
>UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase;
n=106; Bacteria|Rep: Tartrate
dehydrogenase/decarboxylase - Pseudomonas putida
Length = 365
Score = 106 bits (255), Expect = 6e-22
Identities = 78/258 (30%), Positives = 125/258 (48%), Gaps = 25/258 (9%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAAKVP---------IEWEEVDVTAVRG---PDGKFGI 295
++ IPG GIG E+ ++ EAA + EW D G PD +
Sbjct: 7 RIAAIPGDGIGLEVLPEGIRVLEAAALKHGLALEFDTFEWASCDYYLQHGKMMPDD-WAE 65
Query: 296 PQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN- 472
K D++ + + + + SL L R+EFD Y N+RP + G+ N
Sbjct: 66 QLKQYDAIYFGAVDWPDKVPDHISL-WGSL-LKFRREFDQYVNIRPVRLFPGVPCALANR 123
Query: 473 ----VDVVTIRENTEGEYS---GIEHEIVDG-VVQSIKLITEEASTRVAEFAFQFARENK 628
+D V +RENTEGEYS GI E + +V + T R+ ++AF A + +
Sbjct: 124 KVGDIDFVVVRENTEGEYSSLGGIMFENTENEIVIQESIFTRRGVDRILKYAFDLAEKRE 183
Query: 629 RKKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVM 808
RK VT+ K+N M +S + + +A YP + ++ +++ +C V P +FDV+V+
Sbjct: 184 RKHVTSATKSNGMAISMPYWDKRTEAMAAHYPHVSWDKQHIDILCARFVLQPERFDVVVV 243
Query: 809 -PNLYGDIMSDM---CSG 850
NL+GDI+SD+ C+G
Sbjct: 244 ASNLFGDILSDLGPACAG 261
>UniRef50_Q44471 Cluster: Probable tartrate
dehydrogenase/decarboxylase ttuC; n=66; cellular
organisms|Rep: Probable tartrate
dehydrogenase/decarboxylase ttuC - Agrobacterium vitis
(Rhizobium vitis)
Length = 364
Score = 106 bits (255), Expect = 6e-22
Identities = 78/251 (31%), Positives = 120/251 (47%), Gaps = 17/251 (6%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAAKVPI-EWEEVDVTAVRGPD--GKFGI--PQKAIDS 316
K+ IP GIGPE+ A ++ EA + +++ T G D K G+ P +D
Sbjct: 5 KIAAIPADGIGPEVIAAGLQVLEALEQRSGDFKIHTETFDWGSDYYKKHGVMMPADGLDK 64
Query: 317 V---NANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN----- 472
+ +A G G P L L + + FD YANVRP K L GI N
Sbjct: 65 LKKFDAIFFGAVGAPDVPDHITLWGLRLPICQGFDQYANVRPTKILPGITPPLRNCGPGD 124
Query: 473 VDVVTIRENTEGEYSG----IEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKV 640
+D V +REN+EGEYSG + + V + + T TR+ +AF+ A+ RK +
Sbjct: 125 LDWVIVRENSEGEYSGHGGRAHRGLPEEVGTEVAIFTRVGVTRIMRYAFKLAQARPRKLL 184
Query: 641 TAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLY 820
T V K+N R ++ E+AT++PD+ ++ + + + M P D +V NL+
Sbjct: 185 TVVTKSNAQRHGMVMWDEIAAEVATEFPDVTWDKMLVDAMTVRMTLKPETLDTIVATNLH 244
Query: 821 GDIMSDMCSGL 853
DI+SD+ L
Sbjct: 245 ADILSDLAGAL 255
>UniRef50_Q8DTG3 Cluster: 3-isopropylmalate dehydrogenase; n=41;
Bacilli|Rep: 3-isopropylmalate dehydrogenase -
Streptococcus mutans
Length = 344
Score = 105 bits (252), Expect = 1e-21
Identities = 79/254 (31%), Positives = 129/254 (50%), Gaps = 18/254 (7%)
Frame = +2
Query: 146 VRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWE-EVDVTAVRG----------PDGKFG 292
++K+ + G GIGPEI A ++F+A I ++ E++ A G PD
Sbjct: 1 MKKIVTLAGDGIGPEIMAAGLEVFDAVAQKINFDYEIEAKAFGGAGIDASGHPLPDDTLA 60
Query: 293 IPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYD- 469
+ A D++ IG PV + + L LA+RKE +L+AN+RP + + ++ L
Sbjct: 61 AAKTA-DAILLAAIGSPQYDKAPV-RPEQGL-LAIRKELNLFANIRPVRIFDALRHLSPL 117
Query: 470 ------NVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKR 631
VD V +RE T G Y G +H + + I + R+ AF AR +
Sbjct: 118 KAERIAGVDFVVVRELTGGIYFG-QHTLTENSACDINEYSASEIRRIMRKAFAIAR-GRS 175
Query: 632 KKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMP 811
KKVT++ K N++ S L+ + E+A +Y D+ E + + + + M+ +P+ FDV+V
Sbjct: 176 KKVTSIDKQNVLATSK-LWRQIAEEVAKEYSDVTLEHQLVDSAAMVMITNPACFDVVVTE 234
Query: 812 NLYGDIMSDMCSGL 853
NL+GDI+SD S L
Sbjct: 235 NLFGDILSDESSVL 248
>UniRef50_A0P1S6 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Rhodobacterales|Rep: 3-isopropylmalate dehydrogenase -
Stappia aggregata IAM 12614
Length = 369
Score = 105 bits (251), Expect = 2e-21
Identities = 83/259 (32%), Positives = 132/259 (50%), Gaps = 25/259 (9%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAA-----KVPIEWEEVDVTA----VRGPDGKFGIPQK 304
K+ LI G GIG ++ A + E A + ++E+ A G D + G ++
Sbjct: 2 KIALIKGDGIGVDVAEAAIAVLETALKHTGEPAPRYDEIQAGAGYFKETGLDIEDGGEER 61
Query: 305 A--IDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGI-KTLYD-- 469
A D++ IGL P + S +L LR F LYA VRP K+ + L D
Sbjct: 62 AGLADAIFLGAIGL--PSIRHANGTEISPHLRLRDRFGLYAGVRPVKAYPNAPQRLADPR 119
Query: 470 --NVDVVTIRENTEGE-YSGIEHE----IVDGVVQSIKLITEEASTRVAEFAFQFARENK 628
+D+V +RE+TEG YS H+ + D VQ + IT + +T++ FAF AR+ +
Sbjct: 120 AAGIDLVILRESTEGLFYSAAAHKRSLVVNDDEVQDVLRITRKTTTKLHRFAFNLARKRR 179
Query: 629 RK----KVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFD 796
+ ++T V KAN+ S F + E+ +++ D+ Y+ L++V+ P +FD
Sbjct: 180 ERGHPGRLTCVDKANVFT-SLAFFRQIFDEVKSEFADVPVGYNYVDAQALDLVRKPWEFD 238
Query: 797 VLVMPNLYGDIMSDMCSGL 853
VLVM N++GDI+SD+ GL
Sbjct: 239 VLVMENMFGDILSDLAGGL 257
>UniRef50_Q13FQ0 Cluster: Tartrate dehydrogenase; n=3;
Proteobacteria|Rep: Tartrate dehydrogenase -
Burkholderia xenovorans (strain LB400)
Length = 364
Score = 103 bits (248), Expect = 4e-21
Identities = 70/251 (27%), Positives = 119/251 (47%), Gaps = 17/251 (6%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAA-----KVPIEWEEVDVTAVRGPDGKFGIPQKAIDS 316
++ IPG GIG E+ A ++ EA E+E + +P +D+
Sbjct: 5 RIATIPGDGIGKEVIPAGAQVLEALARTSKSFAFEFENFGWGGDYYREHGVMMPADGLDA 64
Query: 317 V---NANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGI-----KTLYDN 472
+ +A G G P L L + + FD YANVRP + L GI + +
Sbjct: 65 IRNKDAILFGSAGDPDIPDHITLWGLRLKICQGFDQYANVRPTRILPGIDGPLKRCKPGD 124
Query: 473 VDVVTIRENTEGEYSGIEHEIVDG----VVQSIKLITEEASTRVAEFAFQFARENKRKKV 640
++ V +REN+EGEYSG+ + G + ++T R+ FAF+ A+ RK +
Sbjct: 125 LNWVIVRENSEGEYSGVGGRVHQGHPIEAATDVSILTRAGVERIMRFAFRLAQSRPRKLL 184
Query: 641 TAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLY 820
T + K+N R + L+ E++ ++PD+K++ + M+ P+ D +V NL+
Sbjct: 185 TVITKSNAQRHAMVLWDEIALEISKEFPDVKWDKELVDASTARMINRPATLDTIVATNLH 244
Query: 821 GDIMSDMCSGL 853
DI+SD+ + L
Sbjct: 245 ADILSDLAAAL 255
>UniRef50_O67480 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=3; Aquificaceae|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Aquifex aeolicus
Length = 426
Score = 103 bits (247), Expect = 6e-21
Identities = 90/285 (31%), Positives = 139/285 (48%), Gaps = 52/285 (18%)
Frame = +2
Query: 155 VTLIPGHGIGPEIT--------VAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFG--IPQK 304
+ I G GIGPEIT AV+K + +K I W V++ A + K G +PQ+
Sbjct: 41 IPFIEGDGIGPEITQAMLLIINTAVEKTYNGSK-KIYW--VELLAGDKAEEKTGERLPQE 97
Query: 305 AIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN---V 475
+D + + +G+KGPL TPVGKG RS+N ALR+ FD Y+ VRP + G T N V
Sbjct: 98 TLDVLKESIVGIKGPLGTPVGKGVRSINSALRRAFDYYSAVRPVYWM-GQATPIPNPERV 156
Query: 476 DVVTIRENTEGEYSGIE-----------HEIV------------DGVVQSIKLITEEAST 586
D+V RENT+ Y+G+E E + + V ++K ++E +
Sbjct: 157 DLVVFRENTDDVYAGVEFFAGTPEAKKVREFLIKEMGAKEEGFPEDVGITVKPMSEFKTK 216
Query: 587 RVAEFAFQFARENKRKKVTAVHKANIMRMSXGLFLRCCRELATK---------YPD---- 727
R A ++A EN +K V + K NIM+ + G F+ E+A + P+
Sbjct: 217 RHVRKALRYALENNKKNVAVIGKGNIMKATEGAFINWAFEVAEEPEFKGKVVTDPEAEPG 276
Query: 728 ---IKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGL 853
+K + + +V P +DV++ NL GD +SD+ + L
Sbjct: 277 EGQVKLTKVITDQMLMQLVLKPEAWDVIIAQNLNGDYVSDLAASL 321
>UniRef50_Q0W5L4 Cluster: 3-isopropylmalate dehydrogenase; n=10;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Uncultured methanogenic archaeon RC-I
Length = 380
Score = 103 bits (246), Expect = 8e-21
Identities = 72/270 (26%), Positives = 131/270 (48%), Gaps = 40/270 (14%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAAK----VPIEWEEVDVTAVRGPDGKFGIPQKAIDSV 319
KV +I G GIGPE+ +K+ AA+ +EW ++ +A I + ++ +
Sbjct: 5 KVPVIAGDGIGPEVIAEGRKVIAAAQEVYNFDVEWIDMPFSADHYVKTGETISESSLKEL 64
Query: 320 NANKIGLKGPL----MTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYD-----N 472
+ + G + G + + L +R +D Y N+RP K +EG++T +
Sbjct: 65 SKYRAIFLGSIGDDRKVKPGVLEKGILLTMRFYYDQYVNLRPVKLMEGVETPLKGKTAAD 124
Query: 473 VDVVTIRENTEGEYSGI-----------EHEIV----------------DGVVQSIKLIT 571
+D +RENTE Y GI E E++ D + + +++
Sbjct: 125 IDFYVVRENTEDFYVGIGGRSKKGTSKQELEVIRQMYSVKFGLDVETDSDEIAYQLGVVS 184
Query: 572 EEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYL 751
+E + R+ E++F A +K +++V KAN++ G + + A KYPD+K + Y+
Sbjct: 185 KEGAKRIIEYSFDLANSRPKKHLSSVDKANVLTDIYGFWREVFTDTAAKYPDVKTDFNYV 244
Query: 752 XTVCLNMVQDPSKFDVLVMPNLYGDIMSDM 841
V + V++P FDV+V PN++GDI++D+
Sbjct: 245 DAVTMWFVKNPEFFDVVVSPNMFGDIITDL 274
>UniRef50_Q8E9N3 Cluster: 3-isopropylmalate dehydrogenase; n=148;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Shewanella oneidensis
Length = 364
Score = 103 bits (246), Expect = 8e-21
Identities = 75/252 (29%), Positives = 129/252 (51%), Gaps = 23/252 (9%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAAK----VPIEWEEVDVTAVRGPDGKFGIPQ------ 301
++ ++ G GIGPE+ +K+ +A + + IE+ E DV + + +P+
Sbjct: 4 QIAVLAGDGIGPEVMAEARKVLKAVEARFGLNIEYTEYDVGGIAIDNHGCPLPEATLKGC 63
Query: 302 KAIDSVNANKIG-LKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCK---SLEGIKTLYD 469
+A D++ +G K + P + R L LR F+L+ N+RP K LE + L
Sbjct: 64 EAADAILFGSVGGPKWEKLPPNEQPERGALLPLRGHFELFCNLRPAKLHDGLEHMSPLRS 123
Query: 470 NV-----DVVTIRENTEGEY----SGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARE 622
++ DV+ +RE T G Y G + E + +R+A AF+ AR
Sbjct: 124 DISARGFDVLCVRELTGGIYFGKPKGRQGEGESEEAFDTMRYSRREISRIARIAFEAAR- 182
Query: 623 NKRKKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVL 802
+RKKVT+V KAN++ S L+ + E+A +PD++ E Y+ + +++ P +FDV+
Sbjct: 183 GRRKKVTSVDKANVLACSV-LWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFDVM 241
Query: 803 VMPNLYGDIMSD 838
+ NL+GDI+SD
Sbjct: 242 LCSNLFGDILSD 253
>UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Saccharopolyspora erythraea NRRL 2338|Rep:
3-isopropylmalate dehydrogenase - Saccharopolyspora
erythraea (strain NRRL 23338)
Length = 407
Score = 102 bits (244), Expect = 1e-20
Identities = 80/246 (32%), Positives = 112/246 (45%), Gaps = 18/246 (7%)
Frame = +2
Query: 155 VTLIPGHGIGPEITVAVQKIFEAAK---VPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNA 325
+ +IPG GIGPE+ + ++ AA V + + D A + ++ +
Sbjct: 9 IAVIPGDGIGPELVRSAVEVLRAAAGRDVELRFTSEDAGADAFRRTGSAMSAATLERIRT 68
Query: 326 NKIG-LKGPL-----MTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN--VDV 481
G LKGP+ P G L LR D YANVRP L G+ VD
Sbjct: 69 RYHGVLKGPVGLPGVRHPDGTEAGLLGGVLRGGLDTYANVRPIALLPGVDAPLRGTAVDY 128
Query: 482 VTIRENTEGEYSGIEHEIV-DGVVQSIKLITEEASTRVAEFAFQFARENKR------KKV 640
V +RENTEG Y + D L+T RV AF+ A ++V
Sbjct: 129 VIVRENTEGLYLSRGRGVGNDRACADQLLMTRHGVERVVVHAFELATRRTGAPADGVRRV 188
Query: 641 TAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLY 820
T V K+N++R S F E+AT+YP ++ + RY ++V DP +FDVLVM N
Sbjct: 189 TCVDKSNVLR-SFAFFREVFDEVATRYPQVEADHRYADAAGHDLVADPGRFDVLVMENFL 247
Query: 821 GDIMSD 838
GDI+SD
Sbjct: 248 GDILSD 253
>UniRef50_Q03UM1 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Leuconostocaceae|Rep: 3-isopropylmalate dehydrogenase -
Leuconostoc mesenteroides subsp. mesenteroides (strain
ATCC 8293 /NCDO 523)
Length = 357
Score = 101 bits (241), Expect = 3e-20
Identities = 74/248 (29%), Positives = 122/248 (49%), Gaps = 15/248 (6%)
Frame = +2
Query: 140 TGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDG--KFG--IPQKA 307
T V+K+ ++ G IGPEI A + +AA + + A G DG + G +PQ
Sbjct: 2 TSVKKIVVLKGDYIGPEIMTAGLAVLDAATKDTTFAYELIDAPFGGDGIDRAGDPLPQST 61
Query: 308 ID-SVNANKIGLK---GPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEG------IK 457
ID S A+ + L GP + L +R + +L+AN+RP K +K
Sbjct: 62 IDVSKQADAVLLSAIGGPKWDNAPRRPEQGLLEIRSKLNLFANIRPTKVTAAQIDRSPLK 121
Query: 458 TLY-DNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRK 634
Y +N D V +RE T G Y G ++ +EE TR+ F+ A++ + K
Sbjct: 122 PEYVENTDFVIVRELTSGAYFGKPRKLEAHQAIDTMYYSEEEVTRIMHQGFKMAQK-RNK 180
Query: 635 KVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPN 814
VT V K+N++ S + + E+ Y D+ + Y+ + + ++ P+ FDV+++PN
Sbjct: 181 HVTIVDKSNVLATSK-FWRKIANEVGKSYQDVTIDYYYVDAMTMAIMAKPTTFDVVIIPN 239
Query: 815 LYGDIMSD 838
L+GDI+SD
Sbjct: 240 LFGDILSD 247
>UniRef50_Q1IZK2 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Deinococcus geothermalis (strain DSM 11300)
Length = 351
Score = 99.5 bits (237), Expect = 9e-20
Identities = 73/249 (29%), Positives = 120/249 (48%), Gaps = 17/249 (6%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 331
KV +PG GIGPE+T A ++ + EE + PQ+ D++
Sbjct: 3 KVVTLPGDGIGPEVTAAAAEVLREVAPDVHIEEHAIGGAAYEQFGDPFPQRTRDALGDAD 62
Query: 332 IGLKGPLMTPVGKGYRSLN---------LALRKEFDLYANVRPCKSLEGIKTLYD----- 469
L G + + SL LALR+ YAN+RP + L G++ L
Sbjct: 63 AVLLGTVGGAQNSPWNSLPRPLRPESGLLALRRALGCYANLRPVRVLPGLEHLSPLKPEL 122
Query: 470 --NVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVT 643
VD++ +RE G Y + +I + T RVA AF +A E +R +VT
Sbjct: 123 ARGVDILIVRELLGGIYFDGDRKIEGDTAYNTMRYTTPEVERVARVAF-WAAEQRRGRVT 181
Query: 644 AVHKANIMRMSXGLFLRCCRELATK-YPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLY 820
+V KAN++ +S L+ R + L + Y ++ Y+ +V + +V +PS++DV++ NL+
Sbjct: 182 SVDKANVLEVSE-LWRRDVQALRDREYRNVHLNHEYVDSVAMLIVANPSRYDVILTENLF 240
Query: 821 GDIMSDMCS 847
GDI+SD+ +
Sbjct: 241 GDILSDLAA 249
>UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: LeuB
protein - Bradyrhizobium japonicum
Length = 359
Score = 99.1 bits (236), Expect = 1e-19
Identities = 73/248 (29%), Positives = 121/248 (48%), Gaps = 19/248 (7%)
Frame = +2
Query: 155 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFG--IPQ------KAI 310
+ ++ G GIGPE+ A + +A VD A K G P +
Sbjct: 7 IAVVHGDGIGPEVARAAVAVLQAGVQAGTLRFVDYPAGADHFLKTGDSFPAASFEGCRTA 66
Query: 311 DSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN---VDV 481
D++ G+ G + + L LR + DL+ANVRP K +G+ + +D
Sbjct: 67 DAILHGAAGIPGVVHPDGTEAGLDFTLTLRFKLDLFANVRPIKLYKGVPSPLGRPGPIDY 126
Query: 482 VTIRENTEGEYS--GIEHEIVDGVVQSIKLITEEASTRVAEFAFQFAR------ENKRKK 637
V +REN+EG Y+ G + + V + T + R+ FAF+ AR ++ R++
Sbjct: 127 VIVRENSEGLYAARGAGALLREEVAVDTLVQTRKGVERIVRFAFELARTRNGSPKDGRRR 186
Query: 638 VTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNL 817
VT KAN++R + F E+A +YPDI+ E + + +++V P+ FDV+V N+
Sbjct: 187 VTCCDKANVLR-TYAFFRAVFDEVAKEYPDIEAEHVLVDAMTVHLVNKPTHFDVIVTENM 245
Query: 818 YGDIMSDM 841
+GDI+SD+
Sbjct: 246 FGDIISDL 253
>UniRef50_Q7UTP0 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodopirellula baltica
Length = 364
Score = 97.5 bits (232), Expect = 4e-19
Identities = 75/250 (30%), Positives = 120/250 (48%), Gaps = 17/250 (6%)
Frame = +2
Query: 155 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKF-----GIPQKAIDSV 319
+ ++ G GIGPE+ ++ E + ++ E + G++ +PQ A D+
Sbjct: 7 LVILGGDGIGPEVCDQSVRLLEIMQPHLDGVEFQLDRHSVGVGEYQRSGEALPQSAYDAC 66
Query: 320 NANKIGLKGPLMTPVGKGYRSLNLA----LRKEFDLYANVRPCKSLEGIKTLYDN----- 472
A+ L G + P + +A LR+ LY VRP + T
Sbjct: 67 LASDAVLLGAMGLPNVRYPNGKEIAPQLDLRERLQLYGGVRPIRLYHEADTPLKGHGPGE 126
Query: 473 VDVVTIRENTEGEYSGIEH--EIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKK-VT 643
+D V +RE+TEG + G + ++ ++ IT AS RV AF+ AR KK VT
Sbjct: 127 IDFVLVRESTEGLFYGRDAIADLEADEATNLLRITRSASERVCRLAFETARRRDGKKTVT 186
Query: 644 AVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYG 823
+ KAN++ S F E+A ++ DIK E Y+ L +V+ P FDV+V N++G
Sbjct: 187 LIDKANVLS-SMVYFRHVFDEVAKEFLDIKAEHVYVDAAALFLVRRPQDFDVMVTENMFG 245
Query: 824 DIMSDMCSGL 853
DI+SD+ +GL
Sbjct: 246 DILSDLAAGL 255
>UniRef50_Q8A6M0 Cluster: 3-isopropylmalate dehydrogenase; n=42;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
- Bacteroides thetaiotaomicron
Length = 353
Score = 97.1 bits (231), Expect = 5e-19
Identities = 71/248 (28%), Positives = 126/248 (50%), Gaps = 19/248 (7%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAA------KVPIEW-----EEVDVTAVRGPDGKFGIP 298
K+ ++ G GIGPEI+V + A KV E+ + +D P+ + +
Sbjct: 4 KIAVLAGDGIGPEISVQGVDVMSAVCEKFGHKVSYEYAICGADAIDKVGDPFPEETYEVC 63
Query: 299 QKAIDSVNANKIGLKGPLMTPVGKGYRSLNL-ALRKEFDLYANVRPCKSLEGI------- 454
+ A D+V + +G P K L A+RK+ L+AN+RP ++ + +
Sbjct: 64 KNA-DAVLFSAVGDPKFDNDPTAKVRPEQGLLAMRKKLGLFANIRPVQTFKCLIHKSPLR 122
Query: 455 KTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRK 634
L +N D + IRE T G Y G +++ D + T R+ + AF++A + +RK
Sbjct: 123 AELVENADFICIRELTGGMYFGEKYQDNDKAYDT-NYYTRPEIERILKVAFEYAMK-RRK 180
Query: 635 KVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPN 814
+T V KAN++ S L+ + +E+A YP++ + ++ + M+Q+P+ FDV+V N
Sbjct: 181 HLTVVDKANVLASSR-LWRQIAQEMAPNYPEVTTDYMFVDNAAMKMIQEPAFFDVMVTEN 239
Query: 815 LYGDIMSD 838
+GDI++D
Sbjct: 240 TFGDILTD 247
>UniRef50_Q81T67 Cluster: 3-isopropylmalate dehydrogenase; n=9;
Bacillus cereus group|Rep: 3-isopropylmalate
dehydrogenase - Bacillus anthracis
Length = 354
Score = 96.7 bits (230), Expect = 7e-19
Identities = 72/250 (28%), Positives = 119/250 (47%), Gaps = 15/250 (6%)
Frame = +2
Query: 149 RKVTLIPGHGIGPEITVAVQKIFEAAK------VPIEWEEVDVTAVRGPDGKFGIPQKAI 310
+++ + G G+GPE+ + +++ + ++ E A+ G+ +PQ+ +
Sbjct: 3 KRIVCLAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEHFGGVAI-DLTGQ-PLPQRTL 60
Query: 311 DSVNANKIGLKGPLMTPVGKGYRSLN----LALRKEFDLYANVRPCKSLEGIKTLY---- 466
+ A+ L G + P G + LALRK ++ANVRP L
Sbjct: 61 AACLASDAVLLGAVGGPRWDGAKERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLKK 120
Query: 467 -DNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVT 643
D +D V +RE T G Y E D V R+ AFQ A + K KKVT
Sbjct: 121 ADEIDFVVVRELTGGIYFSYPKERTDEVATDTLTYHRHEIERIVSCAFQLASKRK-KKVT 179
Query: 644 AVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYG 823
++ KAN++ S L+ E+A +YPD++ E + + ++++P +FDV+V NL+G
Sbjct: 180 SIDKANVLESSK-LWRIVTEEVALRYPDVELEHILVDAAAMELIRNPGRFDVIVTENLFG 238
Query: 824 DIMSDMCSGL 853
DI+SD S L
Sbjct: 239 DILSDEASVL 248
>UniRef50_Q89RJ1 Cluster: 3-isopropylmalate dehydrogenase; n=7;
Alphaproteobacteria|Rep: 3-isopropylmalate dehydrogenase
- Bradyrhizobium japonicum
Length = 368
Score = 95.9 bits (228), Expect = 1e-18
Identities = 72/263 (27%), Positives = 128/263 (48%), Gaps = 18/263 (6%)
Frame = +2
Query: 119 AGAAQYSTGVRKVTLIPGHGIGPEITV----AVQKIFEAAKVPIEWEEVDVTAVRGPDGK 286
AG + + ++ G GIGPE+ ++KI + + + + E A
Sbjct: 6 AGTPMSANNAFHIAVLAGDGIGPEVMAPAIEVLRKIEQKSDLRFRFTEAPAGANNYLATG 65
Query: 287 FGIPQKAI---DSVNANKIGLKG-PLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGI 454
+P++ I + +A +G G P + + + LR FDLYA VRP + + G+
Sbjct: 66 KSMPERTIKLCEEADAILLGACGLPSVRYPDNTEIAPQIELRFIFDLYAGVRPARLIPGV 125
Query: 455 KTLY-----DNVDVVTIRENTEGEYSGIEHEIVDGV-VQSIKLITEEASTRVAEFAFQFA 616
+ +D+V IRE+TEG ++ + +V + +IT S R+ EF+F+ A
Sbjct: 126 PSPIVGADTRGIDLVVIRESTEGLFASMGKGVVTHEDARETMVITRRTSERLFEFSFRLA 185
Query: 617 RENKRK----KVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDP 784
K + +T V KAN+ + + F E+A K+P+++ + Y+ +V+ P
Sbjct: 186 ARRKARGKPGMLTCVDKANVFK-AFAFFRGIFDEIAKKHPEVRTDRLYVDACSAMLVKRP 244
Query: 785 SKFDVLVMPNLYGDIMSDMCSGL 853
FDV+VM N++GDI+SD+ + L
Sbjct: 245 WDFDVMVMENMFGDIVSDITASL 267
>UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;
n=4; Thermococcaceae|Rep: LeuB-2 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 346
Score = 95.5 bits (227), Expect = 2e-18
Identities = 71/235 (30%), Positives = 118/235 (50%), Gaps = 3/235 (1%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANK 331
+V +I G GIGPE+ + ++ + I + E + + G P D K
Sbjct: 3 RVAVIKGDGIGPEVVDSAIRVVNSVTDRIRFYEFE--GGFEVFKRIGSPISEDDLKEIRK 60
Query: 332 IG--LKGPLMTPVG-KGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENT 502
+ L G TP GYRSL + LRKE DLYAN+R I L + ++V +RENT
Sbjct: 61 MDAILFGATTTPFNVPGYRSLIVTLRKELDLYANLRI------IPDLSNGKEIVIVRENT 114
Query: 503 EGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSXG 682
EG Y+ D + ++IT E + R+A+FA A+E + +T VHKAN+++
Sbjct: 115 EGLYARDGIGFSDRAI-DFRIITLEGARRIAKFAINLAKE-RNSFITFVHKANVLK-GDR 171
Query: 683 LFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCS 847
F E+A + ++ + + + +V++P V++ N++GDI+SD+ +
Sbjct: 172 FFREIVLEIAER-EGVEVREAIIDSFMIKLVKNPWDHGVILTENMFGDIISDLAT 225
>UniRef50_Q48806 Cluster: Protein dlpA; n=4; Legionella
pneumophila|Rep: Protein dlpA - Legionella pneumophila
subsp. pneumophila (strain Philadelphia 1 /ATCC 33152 /
DSM 7513)
Length = 615
Score = 94.7 bits (225), Expect = 3e-18
Identities = 76/273 (27%), Positives = 128/273 (46%), Gaps = 34/273 (12%)
Frame = +2
Query: 137 STGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDS 316
ST K+ ++PG GIG E+T A +FE VP+ D+ IP +
Sbjct: 3 STDPIKIAVLPGDGIGIEVTEATLPVFEVLDVPVILNYGDIGWEFWKKEGAAIPSRTWQL 62
Query: 317 VNANKIGLKGPLMT-PVGKGYRSLNLALRKE--------------FDLYANVRPCKSLEG 451
+ ++ L G + + P + + L+ AL+K DL+ANVRPC S++
Sbjct: 63 IASSDTVLLGAITSKPQREAKQELSNALKKSNPYYVSPVIQLRQGLDLFANVRPCFSIDD 122
Query: 452 IKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSI--------KLITEEAS-------- 583
++ IREN+EG Y G ++ + + S+ + +EAS
Sbjct: 123 QSKPFN---FCIIRENSEGLYCGFDYFPLPKAIHSLLAESQHWQTIPADEASCALRLQSK 179
Query: 584 ---TRVAEFAFQFARENKRKKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLX 754
TR+ +FAF+ A + +VT K N++R S + A +YP I+ + +
Sbjct: 180 SGLTRLFDFAFKHAMQTGMPRVTLADKPNVLRESGEFTRKIFESTAQRYPKIQADILNVD 239
Query: 755 TVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGL 853
V L +++ P KF V+V N++GDI+SD+ +G+
Sbjct: 240 AVALWLIKSPEKFGVIVAENMFGDILSDVGAGV 272
>UniRef50_Q9FMT1 Cluster: 3-isopropylmalate dehydrogenase 3,
chloroplast precursor; n=186; cellular organisms|Rep:
3-isopropylmalate dehydrogenase 3, chloroplast precursor
- Arabidopsis thaliana (Mouse-ear cress)
Length = 409
Score = 92.7 bits (220), Expect = 1e-17
Identities = 80/269 (29%), Positives = 131/269 (48%), Gaps = 25/269 (9%)
Frame = +2
Query: 116 RAGAAQYSTGVRKVTLIPGHGIGPE-ITVA---VQKI-------FEAAKVPIEWEEVDVT 262
R AA + L+PG GIGPE I+VA +QK F+ ++P+ +D+
Sbjct: 36 RCAAASPGKKRYNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFKEMPVGGAALDLV 95
Query: 263 AVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRS--LNLALRKEFDLYANVRPC 436
V P+ F K D++ IG G K R LR++ ++AN+RP
Sbjct: 96 GVPLPEETF-TAAKLSDAILLGAIG--GYKWDKNEKHLRPEMALFYLRRDLKVFANLRPA 152
Query: 437 KSLEGI-------KTLYDNVDVVTIRENTEGEYSGIEHEIV-----DGVVQSIKLITEEA 580
L + K + + VD++ +RE T G Y G I + V S ++
Sbjct: 153 TVLPQLVDASTLKKEVAEGVDMMIVRELTGGIYFGEPRGITINENGEEVGVSTEIYAAHE 212
Query: 581 STRVAEFAFQFARENKRKKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTV 760
R+A AF+ AR+ +R K+ +V KAN++ S L+ + LA++YPD++ Y+
Sbjct: 213 IDRIARVAFETARK-RRGKLCSVDKANVLDASI-LWRKRVTALASEYPDVELSHMYVDNA 270
Query: 761 CLNMVQDPSKFDVLVMPNLYGDIMSDMCS 847
+ +++DP +FD +V N++GDI+SD S
Sbjct: 271 AMQLIRDPKQFDTIVTNNIFGDILSDEAS 299
>UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=504; root|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Helicobacter pylori (Campylobacter pylori)
Length = 425
Score = 92.3 bits (219), Expect = 1e-17
Identities = 72/230 (31%), Positives = 118/230 (51%), Gaps = 42/230 (18%)
Frame = +2
Query: 155 VTLIPGHGIGPEITVAVQKIFEAA-------KVPIEWEEVDVTAV----------RGPDG 283
+ I G GIG +IT A+ K+ ++A + I W EV V P+
Sbjct: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQKFKDYKELSPEE 91
Query: 284 KFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTL 463
++ +P I+++N K+ +KGPL TP+G+G+RSLN+ALR++ DLY +RP + +
Sbjct: 92 QWLLPD-TIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQKMDLYVCLRPVRWYGSPSPV 150
Query: 464 YD--NVDVVTIRENTEGEYSGIE----------------HEIVDGVVQ-------SIKLI 568
+ VD+V REN+E Y+GIE +E+ ++ +K I
Sbjct: 151 KEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVKKIRFPESSGIGVKPI 210
Query: 569 TEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSXGLFLRCCRELATK 718
++E + R+ A ++A +N + VT VHK NIM+ + G F++ LA K
Sbjct: 211 SKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQK 260
>UniRef50_Q9CKK6 Cluster: Idp; n=2; Pasteurellaceae|Rep: Idp -
Pasteurella multocida
Length = 415
Score = 91.1 bits (216), Expect = 3e-17
Identities = 67/226 (29%), Positives = 114/226 (50%), Gaps = 37/226 (16%)
Frame = +2
Query: 155 VTLIPGHGIGPEITVAVQKIFEAA-------KVPIEWEEV----DVTAVRGPDGKFGIPQ 301
+ I G GIG ++T A++ + +AA K I W E+ V G + +P
Sbjct: 29 IPFIEGDGIGVDVTPAMRTVIDAAVEKAYGGKRKISWMEIYAGGKANEVYGENT--WLPD 86
Query: 302 KAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN--- 472
+ + + + +KGPLMTPVG G RSLN+A+R+ DLY +RP + +G + +
Sbjct: 87 ETMTFIRDYHVAIKGPLMTPVGGGIRSLNVAMRQGLDLYNCLRPIRYYDGTPSPVKHPEL 146
Query: 473 VDVVTIRENTEGEYSGIE--------HEIVDGVVQ---------------SIKLITEEAS 583
VD+V REN+E Y+G+E ++++ + Q IK ++++ +
Sbjct: 147 VDMVIFRENSEDIYAGVEWVAGSAEANKVIAFLQQEMGVKKIRFTEDCGIGIKPVSKQGT 206
Query: 584 TRVAEFAFQFARENKRKKVTAVHKANIMRMSXGLFLRCCRELATKY 721
R+ A Q+ +N RK +T VHK NIM+ + G F ++A ++
Sbjct: 207 QRLVRAALQYVIDNDRKSLTLVHKGNIMKFTEGAFKEWGYQVAQEF 252
>UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2;
Bacillaceae|Rep: Tartrate dehydrogenase - Bacillus sp.
B14905
Length = 362
Score = 91.1 bits (216), Expect = 3e-17
Identities = 69/253 (27%), Positives = 123/253 (48%), Gaps = 19/253 (7%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGP--------DGKFGIPQKA 307
K+ +IPG GIG E+ K+ + V + +T + P G+ +P+ A
Sbjct: 5 KMAVIPGDGIGKEVMQEALKVVKC--VQERDSSLQITTMVFPWSSDYYLAHGRM-MPEDA 61
Query: 308 IDSV---NANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY---D 469
++++ +A G G P L + +RK F Y N RP KSL GI + +
Sbjct: 62 LETLQKYDAILFGAIGDARVPDDVTVWELIMPIRKNFQQYVNFRPIKSLPGISSPLAGGN 121
Query: 470 NVDVVTIRENTEGEYSGIEHEIVDGVVQSIKL----ITEEASTRVAEFAFQFARENKRKK 637
++D V REN EGEYS + Q + + +T ++ A ++A+++ + K
Sbjct: 122 DIDFVIFRENAEGEYSDSGGRLYQQQPQEMTIQNTIMTRIGIEKIVRAACEYAQQHGKTK 181
Query: 638 VTAVHKANIMRMSXGLFLRCCRELATKY-PDIKFEXRYLXTVCLNMVQDPSKFDVLVMPN 814
+T+ K+N + S + R+ T+ P+++ E Y+ + V+ P +F+V+V N
Sbjct: 182 LTSATKSNAIIHSMKFWDEYTRKTVTQIAPELQLEAIYIDALVAYFVERPQEFEVVVASN 241
Query: 815 LYGDIMSDMCSGL 853
L+GDI+SD+ S +
Sbjct: 242 LFGDILSDLGSAI 254
>UniRef50_Q7VH33 Cluster: 3-isopropylmalate dehydrogenase; n=11;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Helicobacter hepaticus
Length = 357
Score = 89.0 bits (211), Expect = 1e-16
Identities = 73/255 (28%), Positives = 121/255 (47%), Gaps = 22/255 (8%)
Frame = +2
Query: 149 RKVTLIPGHGIGPEITVAVQKIFEAAKVPIE----WEEVDVTAVRGPDGKFGIPQKAIDS 316
+++ +I G GIG E+ KI +A E +EEV + +P K++
Sbjct: 3 KRIAVIYGDGIGKEVITQALKILKAVAKKYEHTFIFEEVLAGGAAIDECGECLPMKSLQI 62
Query: 317 VNANKIGLKGPLMTPVGKGYRSLN------LALRKEFDLYANVRPCKSLEGI-------- 454
+ L G + P S N L LRKE L+AN+RP L +
Sbjct: 63 CKQSDSVLLGAVGGPKWDNEPSHNRPEKALLTLRKELGLFANIRPATLLPQLSKASPLKD 122
Query: 455 KTLYDNVDVVTIRENTEGEYSGIEHEI--VDGVVQSIKLITEEAST--RVAEFAFQFARE 622
+ L +D + +RE G Y G EH++ ++G + +T AS +A+ AF AR
Sbjct: 123 EILNRGIDFIIVRELIGGVYFG-EHKLEEINGEKVASDAMTYSASQIESIAKVAFNIAR- 180
Query: 623 NKRKKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVL 802
N++K++ V KAN++ S L+ ++A Y D+ Y+ + + + PS+FDV+
Sbjct: 181 NRKKEIVCVDKANVLSSSR-LWREVVDKVAQNYKDVHLSYMYVDNAAMQICRAPSQFDVI 239
Query: 803 VMPNLYGDIMSDMCS 847
+ N++GDI+SD S
Sbjct: 240 LTENMFGDILSDEAS 254
>UniRef50_A6GJ83 Cluster: Isocitrate dehydrogenase; n=1;
Plesiocystis pacifica SIR-1|Rep: Isocitrate
dehydrogenase - Plesiocystis pacifica SIR-1
Length = 344
Score = 87.8 bits (208), Expect = 3e-16
Identities = 65/229 (28%), Positives = 100/229 (43%), Gaps = 1/229 (0%)
Frame = +2
Query: 170 GHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGP 349
G GI E++ AV + +A IE+ VD++ I +A ++ LK P
Sbjct: 16 GDGIARELSQAVHTVADALPFEIEFIPVDLSDESREAKGDAIYDEAEAAMRRYGTSLKYP 75
Query: 350 LMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY-DNVDVVTIRENTEGEYSGIE 526
T S N LR+ + RP ++ GI+T Y + + + +R T G Y
Sbjct: 76 TATTK----ESPNRVLRERCNFAVIHRPVATIPGIQTHYNERIHLDIVRIATGGTYEDAG 131
Query: 527 HEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSXGLFLRCCRE 706
I SI+ I S + FAF+ A + + V A K I + + GLF R
Sbjct: 132 RRINRDTAVSIRAIERRPSVLASRFAFRLA-QLRDSNVIATSKYTIQKATDGLFQEAARG 190
Query: 707 LATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGL 853
+A YP +F + ++ P ++ V+V PN YGD +SDM GL
Sbjct: 191 VARDYPATEFREELFDALLAGIIMRPERYGVIVCPNEYGDFLSDMAYGL 239
>UniRef50_Q2JTN8 Cluster: 3-isopropylmalate dehydrogenase; n=72;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria
bacteriumYellowstone A-Prime)
Length = 381
Score = 87.0 bits (206), Expect = 5e-16
Identities = 75/260 (28%), Positives = 128/260 (49%), Gaps = 26/260 (10%)
Frame = +2
Query: 137 STGVR--KVTLIPGHGIGPEITVAVQKIFEAAKVPI----EWEE-------VDVTAVRGP 277
S+ VR ++T + G GIGPEI + + +A + +W+E + T P
Sbjct: 5 SSAVRTYRITALAGDGIGPEIMQVGRAVLDAVAAQVGFSLQWQEGLIGGAAYEATGDPLP 64
Query: 278 DGKFGIPQKAIDSVNANKIG-LKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCK----- 439
+ Q++ D+V +G K + + R+L L LR L+AN+RP K
Sbjct: 65 PETLKMAQES-DAVYLAAVGDFKYDTLPREKRPERAL-LGLRAGLGLFANLRPVKIFPQL 122
Query: 440 -SLEGIKT-LYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLI-----TEEASTRVAE 598
+K + +D+V +RE T G Y G I S + + +E R+A
Sbjct: 123 VQASSLKPEVVAGIDLVVVRELTGGIYFGQPKGIFTDAKGSRRGVNTMAYSEAEVDRIAR 182
Query: 599 FAFQFARENKRKKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQ 778
AF+ AR+ +R+K+ +V KAN++ +S L+ +A +YPD++ Y+ + +V+
Sbjct: 183 VAFELARK-RRRKLCSVDKANVLEVSQ-LWRERVTAIAAEYPDVELSHLYVDNAAMQLVR 240
Query: 779 DPSKFDVLVMPNLYGDIMSD 838
P +FDV++ NL+GDI+SD
Sbjct: 241 WPKQFDVILTENLFGDILSD 260
>UniRef50_Q1IMD5 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Acidobacteria bacterium Ellin345|Rep: 3-isopropylmalate
dehydrogenase - Acidobacteria bacterium (strain
Ellin345)
Length = 403
Score = 85.4 bits (202), Expect = 2e-15
Identities = 70/281 (24%), Positives = 129/281 (45%), Gaps = 48/281 (17%)
Frame = +2
Query: 155 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKI 334
V +PG GIG ++ ++ EA + D+ + +P + I + +K+
Sbjct: 6 VVTMPGDGIGNQVLPQAIRVLEAVGFEANYVHADIGWECWCNEGNALPDRTIQLLRKHKL 65
Query: 335 GLKGPLMTPV-------------GKG--YRSLNLALRKEFDLYANVRPCKSLEGIKTLY- 466
GL G + + GKG Y S + +R+ F+L +RPC S G +
Sbjct: 66 GLFGAITSKPKKAADAELKPELRGKGLSYFSPIVTMRQLFNLDVCMRPCLSFPGNPLNFI 125
Query: 467 ----------DNVDVVTIRENTEGEYSGIE--------------HEIV--------DGVV 550
VDVV R+NTEG Y+G+E H+ + +
Sbjct: 126 RQTTCGGFEEPQVDVVVFRQNTEGLYAGVEWTNPPENVRTALASHKKFAAFANTPGEELA 185
Query: 551 QSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSXGLFLRCCRELATKYPDI 730
S+++IT++ + R+ E AF+ A++ + K VT K N++R + G+ +++ +YP+I
Sbjct: 186 VSVRIITKKNAQRICEAAFKHAKKYRYKNVTICEKPNVLRETSGMMEEVAKQVQKQYPEI 245
Query: 731 KFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGL 853
+ + + ++P ++ V+V NL+GD++SD +GL
Sbjct: 246 ALWSTNIDAQTMWLTKNPEEYGVIVASNLFGDVISDAFAGL 286
>UniRef50_A7T3D9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 419
Score = 85.4 bits (202), Expect = 2e-15
Identities = 57/162 (35%), Positives = 85/162 (52%), Gaps = 13/162 (8%)
Frame = +2
Query: 155 VTLIPGHGIGPEITVAVQKIFEAA-------KVPIEWEEVDV--TAVRGPDGKFGIPQKA 307
+ I G GIG +I+ + K+ +AA + I W EV A + D +PQ+
Sbjct: 31 IPFIEGDGIGIDISPVMIKVVDAAVQKAYGGERKISWMEVYAGEKATQVYDQDTWLPQET 90
Query: 308 IDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY---DNVD 478
+D+V + +KGPL TPVG G RSLN+ALR++ DLY +RP + EG+ + +VD
Sbjct: 91 LDAVKDYVVSIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRWFEGVPSPVKKPGDVD 150
Query: 479 VVTIRENTEGEYSGIEHEI-VDGVVQSIKLITEEASTRVAEF 601
+ REN+E Y+GIE + + IK + EE F
Sbjct: 151 MTIFRENSEDIYAGIEWKAGSPEATKVIKFLKEEMGVTKIRF 192
>UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma;
n=1; Danio rerio|Rep: Isocitrate dehydrogenase 3 (NAD+)
gamma - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 289
Score = 85.0 bits (201), Expect = 2e-15
Identities = 55/173 (31%), Positives = 91/173 (52%), Gaps = 3/173 (1%)
Frame = +2
Query: 128 AQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKA 307
A+Y G VTLIPG GIGPE+ V+++F + VP+++E V V + + A
Sbjct: 45 AKYG-GRHTVTLIPGDGIGPELLNHVRELFRFSCVPVDFEVVHVNSSSTSEDDIS---NA 100
Query: 308 IDSVNANKIGLKGPLMT--PVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDV 481
I ++ N + LKG + T + ++S N LR DLYANV C+SL G++T + N+D+
Sbjct: 101 IMAIRRNGVALKGNIETNHTMPPNHKSRNNLLRTSLDLYANVMHCQSLPGVQTRHKNIDI 160
Query: 482 VTIRENTEGEYSGIEHEIVDGVVQSIKL-ITEEASTRVAEFAFQFARENKRKK 637
+ I E +E E+E + + +++ + + + R A+ E R K
Sbjct: 161 IIILEKSEFSALLAENEKIKVELLQLRIQLADVINKRRADIILDLNIEKSRVK 213
>UniRef50_Q8YCX4 Cluster: 3-isopropylmalate dehydrogenase; n=126;
Bacteria|Rep: 3-isopropylmalate dehydrogenase - Brucella
melitensis
Length = 370
Score = 85.0 bits (201), Expect = 2e-15
Identities = 78/259 (30%), Positives = 121/259 (46%), Gaps = 24/259 (9%)
Frame = +2
Query: 149 RKVTLIPGHGIGPEITVAVQKIF----EAAKVPIEWEEVDVTA----VRGPDGKFGIPQK 304
RK+ L+PG GIGPE V+K+ + E EE V G +K
Sbjct: 4 RKLLLLPGDGIGPEAMAEVRKVIAFLNSDLNLGFETEEGLVGGCAYDAHGQAISDADMEK 63
Query: 305 AI--DSVNANKIGLKGPLMTPVGKGYRSLN--LALRKEFDLYANVRPCKSLEGIK----- 457
A+ D+V +G GP V R L LRK+ LYAN+RP +
Sbjct: 64 ALAADAVLFGAVG--GPKWDSVPYEVRPEGGLLRLRKDMQLYANLRPAICYPALAHSSSL 121
Query: 458 --TLYDNVDVVTIRENTEGEYSGIEHEIVD-GVVQSIKLITEEAST----RVAEFAFQFA 616
+ + +D++ +RE T G Y G EI+D G Q + T+ T R+A+ AF+ A
Sbjct: 122 KPEVIEGLDILILRELTGGVYFGEPKEIIDLGNGQKRGIDTQVYDTYEIERIADVAFELA 181
Query: 617 RENKRKKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFD 796
R +R KVT++ K N+M+ K+ D++ E + +V+ P +FD
Sbjct: 182 R-TRRNKVTSMEKRNVMKSGVLWNQGVTARHKEKHADVQLEHMLADAGGMQLVRWPKQFD 240
Query: 797 VLVMPNLYGDIMSDMCSGL 853
V++ NL+GD++SD+ + L
Sbjct: 241 VILTDNLFGDLLSDVAAML 259
>UniRef50_Q67LW7 Cluster: Tartrate dehydrogenase; n=2; Bacteria|Rep:
Tartrate dehydrogenase - Symbiobacterium thermophilum
Length = 359
Score = 84.6 bits (200), Expect = 3e-15
Identities = 69/251 (27%), Positives = 116/251 (46%), Gaps = 22/251 (8%)
Frame = +2
Query: 155 VTLIPGHGIGPEITVAVQKIFEAAK-----VPIEWEEVDVTAV-------RGPDGKFGIP 298
V +IPG GIG E A +++ +AA + E+ E + P G F
Sbjct: 6 VAVIPGDGIGNETVRAGRRVLDAAAELDGGIKFEYTEFEWGCAYYLRHGEMAPKG-FLNT 64
Query: 299 QKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY---- 466
D++ +G G P L L +R+ F+ Y N+RP + L G+ +
Sbjct: 65 LANFDTILLGAVGYPG---VPDHVSLWGLLLPIRRGFEQYVNLRPVRILRGVVSPLRGRN 121
Query: 467 -DNVDVVTIRENTEGEYSGIEHEIVDG----VVQSIKLITEEASTRVAEFAFQFARENKR 631
+V+ V IRENTEGEYS + + G VV + T + R+ +A+Q A R
Sbjct: 122 PGDVNFVCIRENTEGEYSNMGGRLHAGLPHEVVVQNTVFTRVGTERIIRYAYQLAANAPR 181
Query: 632 KKVTAVHKANIMRMSXGLFLRCCRELATK-YPDIKFEXRYLXTVCLNMVQDPSKFDVLVM 808
K++ K+N + + + E+ + +P++ ++ + N V P +FDV+V
Sbjct: 182 KRLCGATKSNGINYTMPYWDEIFNEIGEREFPEVNRWLCHIDALAANFVLKPDEFDVVVA 241
Query: 809 PNLYGDIMSDM 841
NL+GDI++D+
Sbjct: 242 SNLFGDILTDL 252
>UniRef50_Q7UIE1 Cluster: 3-isopropylmalate dehydrogenase; n=4;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodopirellula baltica
Length = 359
Score = 84.2 bits (199), Expect = 4e-15
Identities = 73/255 (28%), Positives = 123/255 (48%), Gaps = 22/255 (8%)
Frame = +2
Query: 155 VTLIPGHGIGPEIT----VAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSV- 319
+ L+PG GIGPEI + + K+ E ++ + + + +PQ ID+
Sbjct: 5 IVLLPGDGIGPEIVEQARLVLVKVAERFGHTFDFSSHQIGGIAIDETGDPLPQPTIDACR 64
Query: 320 NANKI---GLKGPLMT-PVGKGYRSLNLA-LRKEFDLYANVRPCKSLEGIKT-------L 463
NA I + GP P K L +RKE L+AN+RP K + + +
Sbjct: 65 NAAAILLGAVGGPKWDDPSAKTRPEAGLLKIRKELGLFANLRPIKLFDELADASPLRADI 124
Query: 464 YDNVDVVTIRENTEGEYSGIEHEIVDG----VVQSIKLITEEASTRVAEFAFQFARENKR 631
D++ RE T G Y G G QS+ E R+ A Q AR +
Sbjct: 125 VKGTDILFFRELTGGIYFGESGTSGSGEEETAFQSMTYSVGEVK-RIVRMAAQAAR-GRS 182
Query: 632 KKVTAVHKANIMRMSXGLFLRCCRE-LATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVM 808
++T+V KAN++ S L+ R E +A ++PD++++ + ++ ++++ PS+FDV+V
Sbjct: 183 NRLTSVDKANVLEPSR-LWRRVAAEVMANEFPDVQYDVVLVDSMAMHLINRPSEFDVVVT 241
Query: 809 PNLYGDIMSDMCSGL 853
N++GDI++D S L
Sbjct: 242 GNMFGDILTDEASML 256
>UniRef50_Q05FQ8 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Candidatus Carsonella ruddii PV|Rep: 3-isopropylmalate
dehydrogenase - Carsonella ruddii (strain PV)
Length = 349
Score = 83.0 bits (196), Expect = 9e-15
Identities = 67/246 (27%), Positives = 121/246 (49%), Gaps = 17/246 (6%)
Frame = +2
Query: 161 LIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPD-GKFGIPQ--------KAID 313
++PG GIGPEI V KI ++ + + G KF P K ID
Sbjct: 6 ILPGDGIGPEIIKQVIKIVKSCIYTGYKINIIYNYIGGISIDKFNTPITNNLISIIKYID 65
Query: 314 SVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIR 493
++ +G + K L L LRK+F+ + N+RP IK + N+D++ +R
Sbjct: 66 TIFLGCVG-GYKWNHSIFKPEYGL-LKLRKKFNFFTNIRP------IKCPFKNIDIIIVR 117
Query: 494 ENTEGEY----SGIEHEIVDGV----VQSIKLITEEASTRVAEFAFQFARENKRKKVTAV 649
E G Y G +I++ + + K+ E+ R+A +F A N++KK+ ++
Sbjct: 118 ELNGGIYYGKPKGFSKQIINQIPTWYAYNTKIYNEQEIIRLARISFNLAL-NRKKKLCSI 176
Query: 650 HKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDI 829
K+N++ + L+ + + Y +K Y+ ++++++ +KFDV++ NL+GDI
Sbjct: 177 DKSNVLE-TFKLWKKTINYVHKFYNKVKLSHIYIDYATIDLIKNFNKFDVIITSNLFGDI 235
Query: 830 MSDMCS 847
+SD+CS
Sbjct: 236 ISDLCS 241
>UniRef50_A0ZF75 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Nostocaceae|Rep: 3-isopropylmalate dehydrogenase -
Nodularia spumigena CCY 9414
Length = 422
Score = 82.6 bits (195), Expect = 1e-14
Identities = 72/252 (28%), Positives = 119/252 (47%), Gaps = 18/252 (7%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVA-VQKIFEAAKVP-----IEWEEVDVTAVRGPDGKFG--IPQKA 307
++ IPG GIGPE+ A +Q + + AK+ +++ + TA+ KFG PQ
Sbjct: 69 RIVAIPGEGIGPEVVAASLQLLQQVAKLEGFTLQVDYGWLGTTALE----KFGTYFPQAT 124
Query: 308 IDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYD------ 469
+ N G G + V +G L LRK +D + N+RP + ++ +
Sbjct: 125 AELCN----GSDGIVFGAVTQGGL---LELRKHYDFFCNLRPIRIVDSLVNKSSLRPEKI 177
Query: 470 -NVDVVTIRENTEGEYSGIEHEIVD---GVVQSIKLITEEASTRVAEFAFQFARENKRKK 637
+D++ IRE G Y G D L + R+A A Q A++ +R K
Sbjct: 178 KGLDILVIRELVSGIYFGSAGRASDEKGAYGYHTMLYYDHEIRRLARQALQKAQQ-RRGK 236
Query: 638 VTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNL 817
+T HK N + + R +E A ++PD+ E + + + MV +P +FDV++ NL
Sbjct: 237 LTVAHKENALPNLP--WTRLVQEEAAQFPDVIVEPMLVDNLAMQMVMNPQRFDVILASNL 294
Query: 818 YGDIMSDMCSGL 853
+GDI+SD+ L
Sbjct: 295 FGDILSDIGGAL 306
>UniRef50_A5URE6 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=4; Chloroflexaceae|Rep: Isocitrate dehydrogenase,
NADP-dependent - Roseiflexus sp. RS-1
Length = 453
Score = 81.8 bits (193), Expect = 2e-14
Identities = 48/135 (35%), Positives = 75/135 (55%), Gaps = 10/135 (7%)
Frame = +2
Query: 155 VTLIPGHGIGPEITVAVQKIFEAA-------KVPIEWEEVDVTAVRGPDGKFGIPQKAID 313
+ + G G GP+I A ++F+AA + + W EV +P + ++
Sbjct: 29 IPYVEGDGTGPDIWRASVRVFDAAVERAYGGRRKLMWYEVLAGEKAFNLTGNWLPDETVE 88
Query: 314 SVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY---DNVDVV 484
+ +G+KGPL TPVG+G RSLN+ALR+ DLY +RP + +G+ + + VD+V
Sbjct: 89 AFRQYLVGIKGPLTTPVGRGIRSLNVALRQLLDLYVCLRPVRYFQGVPSPVKRPELVDMV 148
Query: 485 TIRENTEGEYSGIEH 529
RENTE Y+GIE+
Sbjct: 149 IFRENTEDIYAGIEY 163
Score = 37.9 bits (84), Expect = 0.32
Identities = 17/44 (38%), Positives = 27/44 (61%)
Frame = +2
Query: 557 IKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSXGLF 688
IK ++ + R+ A Q+A ++R+ VT VHK NIM+ + G F
Sbjct: 218 IKPVSRLGTERLVAAAIQYAITHRRRSVTFVHKGNIMKFTEGAF 261
>UniRef50_A6PN62 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Victivallis vadensis ATCC BAA-548|Rep: 3-isopropylmalate
dehydrogenase - Victivallis vadensis ATCC BAA-548
Length = 369
Score = 80.6 bits (190), Expect = 5e-14
Identities = 70/266 (26%), Positives = 116/266 (43%), Gaps = 34/266 (12%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAAK----VPIEWEEVDVTAVRGPDGKFGIPQKAIDSV 319
K+ ++PG G GPE+ K+ +AA E E + +P A + +
Sbjct: 6 KIAVLPGDGTGPEVIAEAVKVLDAAGRKFGFTTEKEYYNWGGAHYLATGETLPADAKEQL 65
Query: 320 NANKIGLKGPLMTP-VGKGYRSLNLALRKEFDL--YANVRPCKSLEGIKTLYDN-----V 475
+ L G + P V G + L+ FDL Y N+RP K G++T N +
Sbjct: 66 ARHDAVLLGAIGHPDVKPGVLEKGILLKLRFDLDQYINLRPVKLFPGVETPLANKKPEDI 125
Query: 476 DVVTIRENTEGEYSGIEHEIVDGVVQSIK----LITEEASTRVAEFAFQFARENKRKK-- 637
D V +REN+ G Y+G+ + + + + T R +FAF+ A + K+
Sbjct: 126 DYVVVRENSGGVYTGMGGNVQIDTPEEVACQNWIYTRSQVDRCLKFAFELAEKRHTKENP 185
Query: 638 ----------------VTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLN 769
+T V K N++ GL+ R +A YP +K ++ +
Sbjct: 186 WRGLSEEDKKAGYTSQLTLVGKTNVLTYVCGLWERAFNAMAKNYPTVKTAYCHVDAATMW 245
Query: 770 MVQDPSKFDVLVMPNLYGDIMSDMCS 847
MV++P FDV+V NL GDI++D+ +
Sbjct: 246 MVKNPEWFDVVVTENLMGDIITDLAA 271
>UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=38; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Synechocystis sp. (strain PCC 6803)
Length = 475
Score = 79.8 bits (188), Expect = 8e-14
Identities = 55/154 (35%), Positives = 81/154 (52%), Gaps = 13/154 (8%)
Frame = +2
Query: 155 VTLIPGHGIGPEITVAVQKIFEAA--KVPIEWEEVDVTAVRGPD------GKFGI-PQKA 307
+ I G G G +I A + + AA K EE++ V D G + I P+
Sbjct: 29 IPYIRGDGTGVDIWPATELVINAAIAKAYGGREEINWFKVYAGDEACELYGTYQIFPEDT 88
Query: 308 IDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY---DNVD 478
+ ++ + +KGPL TPVG G RSLN+ALR+ FDLY VRPC+ G + + + +D
Sbjct: 89 LTAIKEYGVAIKGPLTTPVGGGIRSLNVALRQIFDLYTCVRPCRYYPGTPSPHKTPEKLD 148
Query: 479 VVTIRENTEGEYSGIE-HEIVDGVVQSIKLITEE 577
++ RENTE Y GIE E +G + I + +E
Sbjct: 149 IIVYRENTEDIYLGIEWAEGTEGAKKLIAYLNDE 182
>UniRef50_Q89XA0 Cluster: 3-isopropylmalate dehydrogenase 1; n=3;
Bacteria|Rep: 3-isopropylmalate dehydrogenase 1 -
Bradyrhizobium japonicum
Length = 379
Score = 78.6 bits (185), Expect = 2e-13
Identities = 74/256 (28%), Positives = 117/256 (45%), Gaps = 23/256 (8%)
Frame = +2
Query: 155 VTLIPGHGIGPEITVAVQKIF----EAAKVPIEWEEVDVTAVRG-PDGKFGIPQKAIDSV 319
V ++ G GIGPE+T +I + P+ E + GK +P ++++
Sbjct: 10 VAVVGGEGIGPEVTDQSHRILKWFSDRRGAPVILREAQYGLIPYLATGKV-LPDDTVEAM 68
Query: 320 N-ANKI---GLKGPLMTPVGKGYRSLN--LALRKEFDLYANVRPCKSLEGIK-------T 460
A+ I GP T V R L+LR ++DLYAN+RP + +
Sbjct: 69 EEADAILWGATGGPETTEVPPAARKAGSLLSLRSKYDLYANLRPIVANPALADSAPLKAA 128
Query: 461 LYDNVDVVTIRENTEGEYSGIEHEIV---DGVVQSIKL--ITEEASTRVAEFAFQFAREN 625
+ +VD + IRE T G Y G I DG + T RVA AF+ AR
Sbjct: 129 VLKDVDFIIIRELTSGIYFGEPRGIETLPDGQRRGFNTQQYTTSQIRRVARTAFELARTR 188
Query: 626 KRKKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLV 805
K + V +V KAN++ S ++ D++ Y+ + +V+ PS+FDV+V
Sbjct: 189 KGR-VCSVDKANVLETSVLWREEVTALHEAEFSDVELTHLYVDNAAMQIVRAPSQFDVMV 247
Query: 806 MPNLYGDIMSDMCSGL 853
N++GDI+SD C+ +
Sbjct: 248 TCNIFGDILSD-CAAM 262
>UniRef50_A0Q405 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Francisella tularensis|Rep: 3-isopropylmalate
dehydrogenase - Francisella tularensis subsp. novicida
(strain U112)
Length = 359
Score = 77.8 bits (183), Expect = 3e-13
Identities = 69/259 (26%), Positives = 116/259 (44%), Gaps = 24/259 (9%)
Frame = +2
Query: 149 RKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDG----KFGIPQKAIDS 316
+ + ++ G GIGPE+ + K+ + + + A+ G K P++ ++
Sbjct: 3 KNIAILAGDGIGPEVMESAIKVLDTIAKKYNHKFNYIEALIGGAAYVKYKSHCPEETLEI 62
Query: 317 VNANKIGLKGPLMTPVG-------KGYRSLN-LALRKEFDLYANVRPCKSLEGIKT---- 460
+ L G + PV +G + + LALRK F N+RP K ++
Sbjct: 63 CKNSDAILFGSVGGPVEAQNEEKWQGCEANSILALRKHFGFNINIRPSKIFPALREACPL 122
Query: 461 ----LYDNVDVVTIRENTEGEYSGIEHEIVD--GV--VQSIKLITEEASTRVAEFAFQFA 616
+ + D+ RE + Y G D GV I E + AF+ A
Sbjct: 123 KDSRIANGADIEIFRELSRDIYFGEHRTFTDEHGVKCATDIAEYDEHTIRNIVVQAFERA 182
Query: 617 RENKRKKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFD 796
+ + ++T+V KAN++ S L+ E+A YP +K Y+ + MV +PS+FD
Sbjct: 183 TQ-RSNRLTSVDKANVLDTSR-LWRNIVNEVAKDYPSVKVNHMYVDNCAMQMVLNPSQFD 240
Query: 797 VLVMPNLYGDIMSDMCSGL 853
V+V NL+GDI+SD+ S L
Sbjct: 241 VMVTGNLFGDIISDLASVL 259
>UniRef50_Q12545 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Hypocreales|Rep: 3-isopropylmalate dehydrogenase -
Cephalosporium acremonium (Acremonium chrysogenum)
Length = 380
Score = 77.8 bits (183), Expect = 3e-13
Identities = 74/264 (28%), Positives = 122/264 (46%), Gaps = 26/264 (9%)
Frame = +2
Query: 140 TGVRKVTLIPGHGIGPEITVAVQKIFEAAKV--PIEWEEVDVTAVRGPD-GKFGIP--QK 304
T K+ ++PG IGPEI K+ + P + V G G+P Q
Sbjct: 2 TTTYKILVLPGDHIGPEIMAEAIKVLTTIETHRPNLHFNLTTDLVGGTSIDTHGVPITQS 61
Query: 305 AIDSVNANKIGLKGPLMTPVGKGYR----SLNLALRKEFDLYANVRPCK----SLEGIKT 460
+D+ A+ L G + P G S L LR+ D +AN+RPC+ SL G
Sbjct: 62 VLDAAKASDAVLFGSIGGPEWAGVHPTPESGLLQLRQHLDAFANLRPCEFLVPSLVGASP 121
Query: 461 LYDNV----DVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFAR--- 619
+ ++V + +REN G Y G + E D V + + T R+A + AR
Sbjct: 122 IREHVVKGTRFIVVRENCGGAYFGEKKEEED-VASDLWVYTRPEIERLARVSAAVARIMG 180
Query: 620 ----ENKRKKVTAVHKANIMRMSXGLFLRCCREL-ATKYPDIKFEXRYLXTVCLNMVQDP 784
+N+ V + KAN++ S L+ R ++ A ++PDI + + ++ + MV+DP
Sbjct: 181 RSEDDNQAATVWSADKANVL-ASGRLWRRITSDIFAKEFPDITLQHQLADSMAMLMVRDP 239
Query: 785 SKFD-VLVMPNLYGDIMSDMCSGL 853
+F+ V+ N +GDI+SD+ +
Sbjct: 240 RRFNGVIHTDNTFGDILSDISGAI 263
>UniRef50_Q3ZXI7 Cluster: 3-isopropylmalate dehydrogenase; n=66;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Dehalococcoides sp. (strain CBDB1)
Length = 365
Score = 76.2 bits (179), Expect = 1e-12
Identities = 56/167 (33%), Positives = 89/167 (53%), Gaps = 12/167 (7%)
Frame = +2
Query: 389 LALRKEFDLYANVRPCK---SLEG---IKT-LYDNVDVVTIRENTEGEYSGIEHE---IV 538
LALRK L+AN+RP K SL IK + D + IRE T G Y +
Sbjct: 93 LALRKGLGLFANIRPVKVAPSLVNSTPIKAEIVKGTDFIFIRELTGGVYFAKPKKRWTTP 152
Query: 539 DGVVQSIKLIT--EEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSXGLFLRCCRELA 712
G+ ++ +T E R+ F+ A+ N++KK+ +V KAN++ +S L+ + E+A
Sbjct: 153 AGIRKATDSMTYSENEIERIVRVGFELAK-NRKKKLVSVDKANVL-LSSRLWRQIVIEVA 210
Query: 713 TKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGL 853
YP++K E + + ++ P+ FDV+V NL+GDI++D S L
Sbjct: 211 KDYPEVKVEHVLVDACAMKLILAPTYFDVIVTENLFGDILTDEASML 257
>UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9;
Euteleostomi|Rep: NAD+-isocitrate dehydrogenase - Homo
sapiens (Human)
Length = 133
Score = 75.8 bits (178), Expect = 1e-12
Identities = 40/107 (37%), Positives = 69/107 (64%), Gaps = 2/107 (1%)
Frame = +2
Query: 143 GVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVN 322
G VT++PG G+GPE+ AV+++F+AA VP+E++E ++ V+ + + Q + S+
Sbjct: 15 GAFPVTMLPGDGVGPELMHAVKEVFKAASVPVEFQEHHLSEVQNMASEEKLEQ-VLSSMK 73
Query: 323 ANKIGLKGPLMTPVG-KG-YRSLNLALRKEFDLYANVRPCKSLEGIK 457
NK+ + G + TP+ KG S ++ LR++ DL+ANV KSL G++
Sbjct: 74 ENKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVIHVKSLPGVQ 120
>UniRef50_A1SWV5 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Psychromonas ingrahamii 37|Rep: 3-isopropylmalate
dehydrogenase - Psychromonas ingrahamii (strain 37)
Length = 368
Score = 74.9 bits (176), Expect = 2e-12
Identities = 72/262 (27%), Positives = 122/262 (46%), Gaps = 29/262 (11%)
Frame = +2
Query: 155 VTLIPGHGIGPEI---TVAVQKIFEAAKVPIEWEEVDVTAVRG---------PDGKFGIP 298
+ L+ G GIGPE+ V V K+ E + +E DV PD
Sbjct: 6 IALLAGDGIGPEVMKEAVKVLKLIEQRNEDVNFELNDVLFGAAAYFAMGHAFPDETKAAC 65
Query: 299 QKAIDSVNANKIGL--KGPLMTPVGKG-YRSLNLALRKEFDLYANVRPCKSLEGI----- 454
KA D++ IGL + P+ + R L LR+ ++ +AN RP +G+
Sbjct: 66 DKA-DAILKGTIGLNHEDSKKIPIDEQPERGALLPLRRRYNTFANFRPVYLPKGLAHFSP 124
Query: 455 ---KTLYDNVDVVTIRENTEGEYSGIEHEI---VDG--VVQSIKLITEEASTRVAEFAFQ 610
+ + +D++ IRE G Y G E E+ DG V+ + E+ ++ + F+
Sbjct: 125 LKASVIGEGIDIMIIRELVGGLYFG-EKEMGVNADGKRFVREVLEYDEDQIRQIVKVGFE 183
Query: 611 FARENKRKKVTA-VHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPS 787
+ KRKKV +HK+N+++ S L+ E + YP+++ + + + +P
Sbjct: 184 VSM--KRKKVMHNIHKSNVLKSSV-LWNEIVEEESKNYPEVEVKNILVDAAATYLCLNPG 240
Query: 788 KFDVLVMPNLYGDIMSDMCSGL 853
FDV+VM N++GDI+SD G+
Sbjct: 241 MFDVMVMENMFGDILSDQGGGI 262
>UniRef50_A6G3V7 Cluster: Probable 3-isopropylmalate dehydrogenase;
n=1; Plesiocystis pacifica SIR-1|Rep: Probable
3-isopropylmalate dehydrogenase - Plesiocystis pacifica
SIR-1
Length = 368
Score = 74.5 bits (175), Expect = 3e-12
Identities = 61/196 (31%), Positives = 97/196 (49%), Gaps = 23/196 (11%)
Frame = +2
Query: 335 GLKGPLMTPVGK--GYRSLNLALRKEFDLYANVRPCKSLEGI--------KTLYD--NVD 478
G GP++ K G+ + + R +LYANVRP K G+ K +++ VD
Sbjct: 65 GTGGPVLMKDNKMAGFSPV-IGNRMRLNLYANVRPIKLYPGVQHRIHGGHKQIWEAGKVD 123
Query: 479 VVTIRENTEGEYSGIEHEIVDG----VVQSIKLITEEASTRVAEFAFQFA-RENK----- 628
+V IRENTEG Y+ ++ G V ++IT A +V AF+ R NK
Sbjct: 124 MVIIRENTEGLYAPTGGKLAPGGKADVAIDTRVITRRACEQVIRHAFELCKRRNKGAPKD 183
Query: 629 -RKKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLV 805
+ +VTA+ K N++ LF E+ +YP+I+ + + +V P +DV V
Sbjct: 184 GKLRVTAIIKDNVLH-GCQLFRDVFFEIGAEYPEIEKDTAIVDAFTQWLVGQPEYYDVCV 242
Query: 806 MPNLYGDIMSDMCSGL 853
N++GDI++D+ S L
Sbjct: 243 TSNMFGDIVTDLASTL 258
>UniRef50_P04173 Cluster: 3-isopropylmalate dehydrogenase; n=41;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
- Saccharomyces cerevisiae (Baker's yeast)
Length = 364
Score = 73.7 bits (173), Expect = 5e-12
Identities = 69/257 (26%), Positives = 117/257 (45%), Gaps = 24/257 (9%)
Frame = +2
Query: 149 RKVTLIPGHGIGPEITVAVQKIFEA-----AKVPIEWEE-------VDVTAVRGPDGKFG 292
+K+ ++PG +G EIT K+ +A + V ++E +D T V PD
Sbjct: 5 KKIVVLPGDHVGQEITAEAIKVLKAISDVRSNVKFDFENHLIGGAAIDATGVPLPDEALE 64
Query: 293 IPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCK-------SLEG 451
+KA D+V +G GP L +RKE LYAN+RPC L
Sbjct: 65 ASKKA-DAVLLGAVG--GPKWGTGSVRPEQGLLKIRKELQLYANLRPCNFASDSLLDLSP 121
Query: 452 IKTLY-DNVDVVTIRENTEGEYSGIEHE-IVDGVVQSIKLITEEASTRVAEF-AFQFARE 622
IK + D V +RE G Y G E DGV + T R+ AF +
Sbjct: 122 IKPQFAKGTDFVVVRELVGGIYFGKRKEDDGDGVAWDSEQYTVPEVQRITRMAAFMALQH 181
Query: 623 NKRKKVTAVHKANIMRMSXGLFLRCCRE-LATKYPDIKFEXRYLXTVCLNMVQDPSKFD- 796
+ ++ KAN++ S L+ + E + ++P +K + + + + + +V++P+ +
Sbjct: 182 EPPLPIWSLDKANVL-ASSRLWRKTVEETIKNEFPTLKVQHQLIDSAAMILVKNPTHLNG 240
Query: 797 VLVMPNLYGDIMSDMCS 847
+++ N++GDI+SD S
Sbjct: 241 IIITSNMFGDIISDEAS 257
>UniRef50_Q6L0K7 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Thermoplasmatales|Rep: 3-isopropylmalate dehydrogenase -
Picrophilus torridus
Length = 335
Score = 72.9 bits (171), Expect = 9e-12
Identities = 69/251 (27%), Positives = 115/251 (45%), Gaps = 18/251 (7%)
Frame = +2
Query: 155 VTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKI 334
V LIPG GIG EI V + I + D+++ R I ++ + +
Sbjct: 4 VALIPGDGIGREIMPGVAAAISSIS-DINFVTFDISSERYIKTGIIIKDDELEELKNYRA 62
Query: 335 GLKGPLMTP-VGKGY--RSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTE 505
L G + P V G + + L LR+E +LY N+RP +S + D + + +RENT+
Sbjct: 63 ILFGAIGDPRVRPGIMEQGVILRLRRELELYMNIRPVRSFD------DKIKITILRENTQ 116
Query: 506 GEYSGIEHEI-------VDGV-VQSIKLITEEASTRVAEFAFQFARE--NKR-----KKV 640
Y+ I I V+G ++ +E + ++++ ++ NK V
Sbjct: 117 DFYTDISGIIPGKRSFNVNGTRIEIDGSSCDEVYYTMGMLSYRYLKKFFNKAFSICDSTV 176
Query: 641 TAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLY 820
T KAN ++M L+ E A + +I Y + NM+ +P K+ ++ PNLY
Sbjct: 177 TVTDKANAVKM-YNLWRSTAMEAAIE-KNINISFEYADALAYNMILNPKKYRYIIAPNLY 234
Query: 821 GDIMSDMCSGL 853
GDI+SDM + L
Sbjct: 235 GDIISDMGAAL 245
>UniRef50_A1WV93 Cluster: 3-isopropylmalate dehydrogenase; n=7;
Gammaproteobacteria|Rep: 3-isopropylmalate dehydrogenase
- Halorhodospira halophila (strain DSM 244 / SL1)
(Ectothiorhodospirahalophila (strain DSM 244 / SL1))
Length = 389
Score = 68.9 bits (161), Expect = 2e-10
Identities = 75/276 (27%), Positives = 116/276 (42%), Gaps = 42/276 (15%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAAKVP------IEWEEVDVTAVRGP--DGKFGIPQKA 307
+V ++PG GIGPE+ A + EA P + W G +
Sbjct: 9 QVAVMPGDGIGPEVMAATRHALEALPGPALVLTELGWPAHAWHRDHGEMMPADWRGQLAG 68
Query: 308 IDSVNANKIGLKGP------LMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKT-LY 466
D++ +G GP P G L L LRK DL+A RP L G L
Sbjct: 69 YDALLLGALGDPGPSHDAQRYCLPDGVSLAPL-LQLRKGLDLWACERPAVPLAGAPMPLS 127
Query: 467 D----NVDVVTIRENTEGEYSGIEHEIVDGVVQS----IKLITEEASTRVAEFAFQFA-- 616
D + D++ IREN+EGEY + G + +++ T + R+ AF+ A
Sbjct: 128 DPRALHTDLLVIRENSEGEYVDQGGRLAAGTPRETATQLEVFTRAGTERIIRHAFERAAR 187
Query: 617 RENKRKK-----------------VTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXR 745
R +R++ V V K N ++ + L+ E+A +YP I
Sbjct: 188 RAEERRQGLRAPRYAAADGAADAAVCVVTKRNAVQYAGELWSEVFAEVAAEYPGIATHHE 247
Query: 746 YLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGL 853
+ C+ V P +FDV+V NL+GDI++D+ + L
Sbjct: 248 LIDACCMKFVSQPWQFDVVVASNLHGDILTDLAAVL 283
>UniRef50_Q6B458 Cluster: 3-isopropylmalate dehydrogenase; n=30;
Ascomycota|Rep: 3-isopropylmalate dehydrogenase -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 382
Score = 66.1 bits (154), Expect = 1e-09
Identities = 59/258 (22%), Positives = 115/258 (44%), Gaps = 25/258 (9%)
Frame = +2
Query: 149 RKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGI-------PQKA 307
+ +T++PG +G E+ K+ +A + + + + G I P ++
Sbjct: 15 KTITVLPGDHVGEEVCNEAIKVLQAIEDATPYRNIKFNLQKHLIGGAAIDATGTPLPDES 74
Query: 308 IDSVNANKIGLKGPLMTPV-GKGYRSLN---LALRKEFDLYANVRPCK-------SLEGI 454
+++ + L G + P G G L +RKE +LYAN+RPC L +
Sbjct: 75 LEAAKNSDAVLLGAVGGPKWGTGSVRPEQGLLKIRKELNLYANLRPCNFASDSLLELSPL 134
Query: 455 KT-LYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEAS----TRVAEF-AFQFA 616
K+ + D +RE G Y G E + + TE+ S TR+ AF
Sbjct: 135 KSEIVKGTDFTVVRELVGGIYFGERQEQAESEDKQTAWDTEKYSTEEVTRITRMAAFMAL 194
Query: 617 RENKRKKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFD 796
+ N + ++ KAN++ S + ++ ++P + + + + + + +VQ P+K +
Sbjct: 195 QHNPPLPIWSLDKANVLASSRLWRTTVDKVMSEEFPQLTIQHQLIDSAAMILVQSPTKLN 254
Query: 797 -VLVMPNLYGDIMSDMCS 847
+++ N++GDI+SD S
Sbjct: 255 GIIITSNMFGDIISDEAS 272
>UniRef50_A5DIP7 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 173
Score = 65.3 bits (152), Expect = 2e-09
Identities = 46/102 (45%), Positives = 54/102 (52%)
Frame = -2
Query: 456 LIPSKLLQGLTLAYKSNSFLRAKLSDL*PLPTGVIRGPFKPILLAFTESIAFWGIPNLPS 277
L P L A SNSFL A +DL P GV + PF P L F +S A P S
Sbjct: 7 LTPGMFLIKTNEAKISNSFLNATFNDLPDDPVGVNKIPFNPTLFLFNDSTAS-ATPVPLS 65
Query: 276 GPLTAVTSTSSHSIGTLAASKIF*TATVISGPIPCPGMSVTL 151
P TST SHS+GT + K+ T +VIS PIP PGM VT+
Sbjct: 66 KP---ETSTVSHSMGTFSDLKMVLTESVISLPIPSPGMRVTV 104
>UniRef50_O59930 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Dikarya|Rep: 3-isopropylmalate dehydrogenase -
Phanerochaete chrysosporium (White-rot fungus)
(Sporotrichumpruinosum)
Length = 380
Score = 64.5 bits (150), Expect = 3e-09
Identities = 67/257 (26%), Positives = 109/257 (42%), Gaps = 25/257 (9%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTA--VRGPD-GKFGIPQKAIDSVN 322
K+ ++PG GIGPE+ ++ E E+ + G K G P A ++
Sbjct: 7 KIVILPGDGIGPEVVAEATRVLEVVSASSSDVEIKLETHDFGGCSIDKHGEPLTAA-TLE 65
Query: 323 ANKIG---LKGPLMTP---VGKGYRSLN--LALRKEFDLYANVRPCKSLEGIKTLYD--- 469
A K+ L G + P V R LALRK LYAN+RP Y
Sbjct: 66 ACKLADAILLGAIGGPKWGVNSKVRPEQALLALRKALGLYANIRPANFASDSLLAYSPLK 125
Query: 470 -----NVDVVTIRENTEGEYSGIEHEI----VDGVVQSIKLITEEASTRVAEFAFQFARE 622
VD++ IRE G Y G E+ + + + R+ Q A
Sbjct: 126 PSVARGVDIIVIRELIGGAYFGERKELGARAQEDAAWDTMIYSVPEVQRITRSRRQVASP 185
Query: 623 NKRKKVTAVHKANIMRMSXGLFLRCCRE-LATKYPDIKFEXRYLXTVCLNMVQDPSKFD- 796
+ V ++ KAN++ S L+ + E + ++P +K + + + + +V +P K +
Sbjct: 186 DPPLPVHSIDKANVL-ASSRLWRKVATETIQNEFPQLKLDHHLVDSASMLIVANPKKLNG 244
Query: 797 VLVMPNLYGDIMSDMCS 847
V++ NL+GDI+SD S
Sbjct: 245 VILTENLFGDILSDESS 261
>UniRef50_UPI00003C8595 Cluster: hypothetical protein Faci_03000731;
n=1; Ferroplasma acidarmanus fer1|Rep: hypothetical
protein Faci_03000731 - Ferroplasma acidarmanus fer1
Length = 377
Score = 60.9 bits (141), Expect = 4e-08
Identities = 63/258 (24%), Positives = 113/258 (43%), Gaps = 29/258 (11%)
Frame = +2
Query: 164 IPGHGIGPEITVAVQKIFEAA-------KVPIEWEEVDVTAVRGPDGKFG--IPQKAIDS 316
I G GIGPEIT A+ + +A IEW ++ + KFG +P+ +I
Sbjct: 29 IDGDGIGPEITGAMIGVVNSAIELAYQGSRSIEWHKILIGTEAYE--KFGTYVPEDSIKE 86
Query: 317 VNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIK---TLYDNVDVVT 487
+ I +K L K R LN LRK LY+N+R K +EG+ ++ +++
Sbjct: 87 IQKMYIAMKSTLNFMPDK--RDLNTILRKRLGLYSNIRILKYIEGMDIPVNTFNRLNLTI 144
Query: 488 IRENTEGEYSGI-EHEIVDGVVQSIK-----LITEEA-----------STRVAEFAFQFA 616
IR++T + E D +++ I IT ++ + ++A+ A +++
Sbjct: 145 IRDSTPNSHIFYHSSESTDDLIRFISDNYGLNITPDSGIYMMPQSKFRTRKIAKQAVRYS 204
Query: 617 RENKRKKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFD 796
R N +KK+T + F C E A+ D+ +E ++ P F+
Sbjct: 205 RRNGKKKITILES-----QQNHEFANWCIEEASAQEDVGYEVLKTREFMKRLISSPEDFE 259
Query: 797 VLVMPNLYGDIMSDMCSG 850
V+++ N+ + D +G
Sbjct: 260 VILVDNVLSQTLVDYLAG 277
>UniRef50_A5DIP6 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 230
Score = 60.5 bits (140), Expect = 5e-08
Identities = 57/212 (26%), Positives = 92/212 (43%)
Frame = -1
Query: 796 VKLGGVLHHVEADRVQVSLFELDVRVLGGELATTAQEEAV*HTHNISFVYGRDLLPLVFS 617
++LG LH D + +LD RV + E+ + H+I V G D L +V
Sbjct: 1 MRLGHSLHRGIVDN---KIIDLDSRVQLTHIFHGLTEQTISQFHDIGLVDGGDQLTVVLL 57
Query: 616 GELEGELRHSRTGLLRDQLDGLHDSVDDLVLDTGILTLGVLSDRDHVNVVV*CLDPF*TL 437
G+++ +L S L L+ + LV + I T V SD VN + LD
Sbjct: 58 GKVKCKLGDSLGFEPGHDLHRLNHTRVRLVFQSRIFTFSVFSDEGKVNALQTRLDAGNVF 117
Query: 436 ARSDISIQVKLLPEGQVE*SVAFTDWSHQGTLQANFIGIYRVNRFLGNTEFAIWTPNSCY 257
+ S ++ + ++ + WS Q T Q++ + + R + LGN + T N
Sbjct: 118 DQDQRSKNIQFFSQRNIQRFAGRSSWSKQDTFQSHLVSLQRFHS-LGNPGTLVQTRN--- 173
Query: 256 IHFLPFDRYFSCFEDFLNGDRDLGPNTMSRDE 161
I+ PFD E+ L+G D NT+S +E
Sbjct: 174 INSFPFDGDVFRLENGLDGIGDFLTNTISWNE 205
>UniRef50_P34738 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Sordariomycetes|Rep: 3-isopropylmalate dehydrogenase -
Neurospora crassa
Length = 368
Score = 58.4 bits (135), Expect = 2e-07
Identities = 49/165 (29%), Positives = 81/165 (49%), Gaps = 12/165 (7%)
Frame = +2
Query: 389 LALRKEFDLYANVRPC----KSLEGIKTLYDNV----DVVTIRENTEGEYSGIEHE-IVD 541
L LRKE Y N+RPC +SL L V D + +RE T G Y G E
Sbjct: 95 LKLRKELGTYGNLRPCNFASESLVDSSPLKAEVCRGTDFIVVRELTGGIYFGDRTEDDGS 154
Query: 542 GVVQSIKLITEEASTRVAEFA-FQFARENKRKKVTAVHKANIMRMSXGLFLRCCRELATK 718
G + + R+A A F +N KV ++ KAN++ S L+ + ++ +K
Sbjct: 155 GYACDTEPYSRAEIVRIARLAGFLALAKNPPAKVWSLDKANVLATSR-LWRKTVTDVISK 213
Query: 719 -YPDIKFEXRYLXTVCLNMVQDPSKFD-VLVMPNLYGDIMSDMCS 847
+P ++ E + + + + +V++P + V++ NL+GDI+SD S
Sbjct: 214 EFPQLQLEHQLIDSAAMLLVKNPRALNGVVITSNLFGDIISDEAS 258
>UniRef50_A0FP11 Cluster: Isocitrate/isopropylmalate dehydrogenase
precursor; n=1; Burkholderia phymatum STM815|Rep:
Isocitrate/isopropylmalate dehydrogenase precursor -
Burkholderia phymatum STM815
Length = 253
Score = 58.0 bits (134), Expect = 3e-07
Identities = 28/84 (33%), Positives = 50/84 (59%)
Frame = +2
Query: 587 RVAEFAFQFARENKRKKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCL 766
R + AFQ A + + KK+T+V KAN++ S + +++ +Y D++ Y+ +
Sbjct: 80 RASHVAFQ-AAQKRGKKLTSVDKANVLETSQ-FWKDIMIDVSKEYADVELSHMYVDNAAM 137
Query: 767 NMVQDPSKFDVLVMPNLYGDIMSD 838
+V+ P FDV+V N++GDI+SD
Sbjct: 138 QLVKAPKSFDVIVTGNMFGDILSD 161
>UniRef50_Q4V533 Cluster: IP13250p; n=4; Drosophila
melanogaster|Rep: IP13250p - Drosophila melanogaster
(Fruit fly)
Length = 475
Score = 58.0 bits (134), Expect = 3e-07
Identities = 39/170 (22%), Positives = 83/170 (48%), Gaps = 1/170 (0%)
Frame = +2
Query: 143 GVRKVTLIPGHGI-GPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSV 319
G+ V+L+ G I G + V + +++VP+E + ++ G D ++ SV
Sbjct: 61 GINTVSLVTGTTIIGQQGAQFVSSLLSSSRVPVEVQVIEA----GQDDEY------FHSV 110
Query: 320 NANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIREN 499
N+ + ++L + + DLY +S G K + VD+ I +N
Sbjct: 111 LRNRTAVHVDNQADAEAKQKALKIC--NDLDLYVFKTRTRSFPGFKCRFPGVDIQLIGQN 168
Query: 500 TEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAV 649
G ++ +E+ V+GVV+++ +++++ + + +AF+ A + RK+VT +
Sbjct: 169 NMGIFNELEYSPVEGVVEALSVVSQKGNDKYLRYAFKAAAKAGRKRVTLI 218
>UniRef50_Q18WQ3 Cluster: Isocitrate/isopropylmalate dehydrogenase;
n=2; Desulfitobacterium hafniense|Rep:
Isocitrate/isopropylmalate dehydrogenase -
Desulfitobacterium hafniense (strain DCB-2)
Length = 374
Score = 57.6 bits (133), Expect = 4e-07
Identities = 37/148 (25%), Positives = 72/148 (48%), Gaps = 9/148 (6%)
Frame = +2
Query: 425 VRPCKSLEGIKTLYDN---VDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVA 595
+RP + +GI N +DV+ +R+ EG Y H I + ++T + + A
Sbjct: 111 LRPLRLRKGIDCPLRNREEIDVLLVRQLAEGFYIRPGHMIGEDAAYDTIVVTRNVTEKFA 170
Query: 596 EFAFQFAR------ENKRKKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXT 757
+ F+ AR ++ +K VT +K + + + E++ YPDI + +
Sbjct: 171 DTCFRLARGRHGRRQDGKKMVTLGNKHGNVTC-FDFYRKIFTEVSAGYPDIGLQFTQVDA 229
Query: 758 VCLNMVQDPSKFDVLVMPNLYGDIMSDM 841
+ ++++DP +FDV+ N+ GDI+ D+
Sbjct: 230 LAEHLIKDPDRFDVIACENMIGDIIGDI 257
>UniRef50_P56471 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 90
Score = 54.0 bits (124), Expect = 5e-06
Identities = 24/33 (72%), Positives = 28/33 (84%)
Frame = +2
Query: 143 GVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIE 241
GV+ VTLIPG GIGPEI+ AV KIF+AAK PI+
Sbjct: 3 GVKTVTLIPGDGIGPEISAAVMKIFDAAKAPIQ 35
>UniRef50_Q0A635 Cluster: Isocitrate/isopropylmalate dehydrogenase;
n=1; Alkalilimnicola ehrlichei MLHE-1|Rep:
Isocitrate/isopropylmalate dehydrogenase -
Alkalilimnicola ehrlichei (strain MLHE-1)
Length = 382
Score = 53.2 bits (122), Expect = 8e-06
Identities = 59/248 (23%), Positives = 103/248 (41%), Gaps = 15/248 (6%)
Frame = +2
Query: 155 VTLIPGHGIGPE-ITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKF----GIPQKAIDSV 319
V ++PG G+GPE I VA+ + + + EV G + G+ + D
Sbjct: 30 VGVLPGEGVGPEVIDVALSLLRLLGEATGQRFEVRTGGPIGRQAERLTGRGLTPEVRDFC 89
Query: 320 NANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCK---SLEGIKTLYD----NVD 478
A G ++ G G +L R+ FDLY + P + +L L + D
Sbjct: 90 -AQVFAQGGAVLCGPGGGRFVYDL--RRHFDLYCKLIPLRHWPALADAGVLRPEAARSAD 146
Query: 479 VVTIRENTEGEYSGIEHEIVDGVVQSIKLITE---EASTRVAEFAFQFARENKRKKVTAV 649
V+ +REN G Y G +G +S + + R+ A + A + + V
Sbjct: 147 VLIVRENASGLYCGEWGSEGEGAARSAYQVCRYRADEVERILRTALRLAGQRRGDLVVVT 206
Query: 650 HKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDI 829
+ +S L+ +A ++ ++ + ++ DP +FDV+V PN++GDI
Sbjct: 207 KPGGVPAISA-LWHDALTAVAGEHGAVRCRTLEVDNAAYQLIADPRQFDVIVCPNMFGDI 265
Query: 830 MSDMCSGL 853
+ D C L
Sbjct: 266 LGD-CGSL 272
>UniRef50_Q300E7 Cluster: Isocitrate/isopropylmalate dehydrogenase;
n=1; Streptococcus suis 89/1591|Rep:
Isocitrate/isopropylmalate dehydrogenase - Streptococcus
suis 89/1591
Length = 207
Score = 52.8 bits (121), Expect = 1e-05
Identities = 50/193 (25%), Positives = 80/193 (41%), Gaps = 15/193 (7%)
Frame = +2
Query: 149 RKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWE-EVDVTAVRGPD---GKFGIPQKAIDS 316
+K+ + G GIGPEI A ++ EA + ++ E++ A G +P + +
Sbjct: 3 KKIVALAGDGIGPEIMEAGLEVLEAVAGQVGFDYEIEERAFGGAGIDAAGHPLPNATLQA 62
Query: 317 VN-ANKI---GLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTL------- 463
A+ I + P L LRKE L+AN+RP K + +K
Sbjct: 63 CRQADAILLAAIGSPQYDDAAVRPEQGLLQLRKELGLFANIRPVKIFDSLKDYSPLKADR 122
Query: 464 YDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVT 643
D VD+V +RE T G Y G +H + E RV AF A++ ++K
Sbjct: 123 LDGVDLVMVRELTGGIYFG-KHILETYQASDSNTYQAEEIERVVRSAFDLAQKRQKKSPA 181
Query: 644 AVHKANIMRMSXG 682
+ + R + G
Sbjct: 182 LISRMYWRRQNYG 194
>UniRef50_Q67N12 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Symbiobacterium thermophilum
Length = 357
Score = 52.4 bits (120), Expect = 1e-05
Identities = 54/243 (22%), Positives = 99/243 (40%), Gaps = 7/243 (2%)
Frame = +2
Query: 146 VRKVTLIPGHGIGPEITVAVQKIF--EAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSV 319
V + ++ G G E+ ++ + +P+ D++ + +A ++
Sbjct: 4 VPTIVVLEGDQTGQELLEEAVRLLSPDVIGLPLHLVRYDLSLENRRATSNRVVYEAAAAM 63
Query: 320 NANKIGLKGPLMTPVGKG-YRSLNLALRKEFDLYANVRPCKSLEGIKTLYD-NVDVVTIR 493
+ GLK +TP G+G S N LR+E D +R + L G++T+ + +R
Sbjct: 64 REHGYGLKAATITPEGRGDVGSPNAILRREIDGTVILRTGRPLPGVETIGGITAPIAVVR 123
Query: 494 ENTEGEYSGIEHEIVDGVVQSI---KLITEEASTRVAEFAFQFARENKRKKVTAVHKANI 664
TE Y E +G + I+ AEFAF+ AR+ V K +
Sbjct: 124 MATEDAYEAKEWREGEGDEERAFRTTYISARNCRATAEFAFRLARQ-MGALVFGGPKWTV 182
Query: 665 MRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIMSDMC 844
GL E A + PD+ ++ + + ++ ++ V+ N GDI+SD+
Sbjct: 183 SPTYEGLLKEAMDEAARRNPDVPYDPQLIDAAYALLIARATRPLVIPCLNRDGDILSDLV 242
Query: 845 SGL 853
L
Sbjct: 243 LAL 245
>UniRef50_Q4P2R4 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 363
Score = 52.4 bits (120), Expect = 1e-05
Identities = 64/254 (25%), Positives = 110/254 (43%), Gaps = 22/254 (8%)
Frame = +2
Query: 152 KVTLIPGHGIGPEITVAVQKIFEAAK----VPIEWEEVDVTAVRGPDGKFGIPQKAIDSV 319
KV ++ G IGPE+ V +F+ + + +E E + I + +
Sbjct: 14 KVMVLQGDHIGPEVMAEVLPLFDVIQSHFGIKVETFERLIGGSCLDQHDCPIQESTLQEA 73
Query: 320 NANKIGLKGPLMTP---VGKGYRSLN---LALRKEFDLYANVRPCK-------SLEGIKT 460
+ L G + P VG R L +RK +LYANVRP K L +K
Sbjct: 74 SECHAVLLGSVGGPKWDVGDSSRRPETGILRMRKHLNLYANVRPAKIISERQLELSSLKE 133
Query: 461 -LYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKK 637
+ V+++T+REN G Y G + +E + A A +
Sbjct: 134 HVVRGVNIITLRENAGGIYFGRK---------------QEPDPLAHKAALSLASSHGPLP 178
Query: 638 VTAVHKANIMRMSXGLFLRCCRE-LATKYPDI--KFEXRYLXTVCLNMVQDPSKFD-VLV 805
+ +V KAN+M S L+ + E + ++P + K + + + + + +DP K + V++
Sbjct: 179 IISVDKANVMATSR-LWRQVVTETIRDEFPQLMDKLSHQLVDSAAMLLAKDPRKLNGVVL 237
Query: 806 MPNLYGDIMSDMCS 847
NL+GDI+SD+ S
Sbjct: 238 TENLFGDILSDLTS 251
>UniRef50_Q12592 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Ascomycota|Rep: 3-isopropylmalate dehydrogenase -
Candida maltosa (Yeast)
Length = 251
Score = 51.2 bits (117), Expect = 3e-05
Identities = 55/244 (22%), Positives = 103/244 (42%), Gaps = 24/244 (9%)
Frame = +2
Query: 137 STGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGI------- 295
S + +T++PG +G EI K+ EA + ++++ G I
Sbjct: 2 SVKTKTITILPGDHVGTEIVNEAIKVLEAIEAATPYQKIHFDFKHHLIGGAAIDATGVPL 61
Query: 296 PQKAIDSVNANKIGLKGPLMTPV-GKGYRSLN---LALRKEFDLYANVRPCK----SLEG 451
P A++S + L G + P G G L +RKE +LYAN+RPC SL
Sbjct: 62 PDDALESAKNSDAVLLGAVGGPKWGTGALRPEQGLLKIRKELNLYANIRPCNFASDSLLE 121
Query: 452 IKTLYDNV----DVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEAS----TRVAEF-A 604
+ L V +++ +RE G Y G E + + TE+ + TR+ A
Sbjct: 122 LSPLRPEVVKGTNLIIVRELVGGIYFGDREEQEESEDKQTAWDTEKYTVDEVTRITRMAA 181
Query: 605 FQFARENKRKKVTAVHKANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDP 784
F + N + ++ KAN++ S + ++ ++P + + + + + C + P
Sbjct: 182 FMALQHNPPLPIWSLDKANVLASSRLWRRTVDKVISEEFPTLSVQHQLIDSACHDFNSKP 241
Query: 785 SKFD 796
++ +
Sbjct: 242 NQIE 245
>UniRef50_Q2Q9C5 Cluster: Isocitrate dehydrogenase 3 gamma; n=8;
Eutheria|Rep: Isocitrate dehydrogenase 3 gamma - Homo
sapiens (Human)
Length = 88
Score = 48.0 bits (109), Expect = 3e-04
Identities = 27/73 (36%), Positives = 44/73 (60%)
Frame = +2
Query: 125 AAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTAVRGPDGKFGIPQK 304
+A+Y G VT+IPG GIGPE+ + V+ +F A VP+++EEV V++ +
Sbjct: 21 SAKYG-GRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVSSNADEEDIC----N 75
Query: 305 AIDSVNANKIGLK 343
AI ++ N++ LK
Sbjct: 76 AIMAIRRNRVALK 88
>UniRef50_Q08522 Cluster: Putative uncharacterized protein YOR135C;
n=1; Saccharomyces cerevisiae|Rep: Putative
uncharacterized protein YOR135C - Saccharomyces
cerevisiae (Baker's yeast)
Length = 113
Score = 46.8 bits (106), Expect = 7e-04
Identities = 25/43 (58%), Positives = 29/43 (67%), Gaps = 2/43 (4%)
Frame = -2
Query: 273 PLTAV--TSTSSHSIGTLAASKIF*TATVISGPIPCPGMSVTL 151
PLT + TS SHS+GT AA KIF T ISGPIP P M+ T+
Sbjct: 5 PLTKIGLTSQDSHSMGTFAALKIFFTDLEISGPIPSPSMNETV 47
>UniRef50_Q5IWY1 Cluster: Plastid 3-isopropylmalate dehydrogenase;
n=1; Prototheca wickerhamii|Rep: Plastid
3-isopropylmalate dehydrogenase - Prototheca wickerhamii
Length = 211
Score = 42.7 bits (96), Expect = 0.011
Identities = 42/153 (27%), Positives = 63/153 (41%), Gaps = 18/153 (11%)
Frame = +2
Query: 116 RAGAAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAA-----------KVPIEWEEVDVT 262
RA A + +VT++PG GIGPEIT + EAA + I D T
Sbjct: 28 RARPALATCAAHRVTVLPGDGIGPEITAVTLSVLEAAGKAEGESFTFTEALIGGAAYDAT 87
Query: 263 AVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKS 442
PD + + + A G K + V K L L LR + +AN+RP
Sbjct: 88 GDPYPDATYRACADSDAVLLAAIGGYKWDALPSVSKPETGL-LRLRSSLNAFANLRPATV 146
Query: 443 LEGI-------KTLYDNVDVVTIRENTEGEYSG 520
+ + + + + VD++ +RE G Y G
Sbjct: 147 IPELADASSLKREVLEGVDLLIVRELVGGIYFG 179
>UniRef50_Q5A9E0 Cluster: Putative uncharacterized protein; n=1;
Candida albicans|Rep: Putative uncharacterized protein -
Candida albicans (Yeast)
Length = 150
Score = 42.3 bits (95), Expect = 0.015
Identities = 45/124 (36%), Positives = 55/124 (44%), Gaps = 7/124 (5%)
Frame = -2
Query: 513 YSPSVFSLIVTTSTLSYSVLIPSKLLQGLTLAYKSNSFLRAKLSDL*P--LPTGVIRGPF 340
Y SVFS +T ST + IPS L G TLAYK N FL A + + P L G P
Sbjct: 2 YKSSVFSRTITIST---GLPIPSTDLTGSTLAYKPNFFLNATIGEEYPATLVVGDETAPN 58
Query: 339 K-PILLAFTESIAFWG--IPNLPSGPLTAVTSTSSHSIGTLAA--SKIF*TATVISGPIP 175
P F S G +P + A T+S+ LA SK A + S PIP
Sbjct: 59 NAPSHSFFKTSTVSSGKAVPVFLNNSKPASKLTNSNCKSCLAGKFSKTALPAGITSRPIP 118
Query: 174 CPGM 163
PG+
Sbjct: 119 SPGI 122
>UniRef50_P41566 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 106
Score = 39.1 bits (87), Expect = 0.14
Identities = 19/47 (40%), Positives = 31/47 (65%)
Frame = +2
Query: 125 AAQYSTGVRKVTLIPGHGIGPEITVAVQKIFEAAKVPIEWEEVDVTA 265
+A+Y G+ VT+ PG G GPE+ + V +A VP+++EEV V++
Sbjct: 9 SAKYG-GILTVTMSPGDGDGPELMLTVXXXXXSACVPVDFEEVVVSS 54
>UniRef50_A2E7S3 Cluster: Putative uncharacterized protein; n=1;
Trichomonas vaginalis G3|Rep: Putative uncharacterized
protein - Trichomonas vaginalis G3
Length = 1175
Score = 36.3 bits (80), Expect = 0.98
Identities = 20/75 (26%), Positives = 40/75 (53%), Gaps = 3/75 (4%)
Frame = +2
Query: 326 NKIGLKGPLMTPVGKGYRSLNLALRKEFDL---YANVRPCKSLEGIKTLYDNVDVVTIRE 496
NK+ L G + V KG+ + L++ K+ + Y +V + L + T N+ +++ +
Sbjct: 533 NKLNLNGSALIAVVKGFLNGELSMWKKISMDTNYMHVSDLQLLTALFTRMPNLRELSLSD 592
Query: 497 NTEGEYSGIEHEIVD 541
N + +GIE+E+ D
Sbjct: 593 NFDASMAGIEYELPD 607
>UniRef50_Q8WWQ4 Cluster: Mucin 5; n=5; Catarrhini|Rep: Mucin 5 - Homo
sapiens (Human)
Length = 1349
Score = 36.3 bits (80), Expect = 0.98
Identities = 39/157 (24%), Positives = 63/157 (40%), Gaps = 1/157 (0%)
Frame = -2
Query: 621 SLANW-KANSATLVLASSVISLMDCTTPSTISCSIPEYSPSVFSLIVTTSTLSYSVLIPS 445
S ++W K+ + TLV S+ + TT + + +IP +PS S T++T + + S
Sbjct: 1056 STSSWQKSRTTTLVTTSTTSTPQTSTTSAPTTSTIPASTPSTTSAPTTSTTSAPTTSTTS 1115
Query: 444 KLLQGLTLAYKSNSFLRAKLSDL*PLPTGVIRGPFKPILLAFTESIAFWGIPNLPSGPLT 265
T +++ L S T P + A T S + S P +
Sbjct: 1116 APTHRTTSGPTTSTTLAPTTSTTSAPTTSTNSAPTTSTISASTTSTISAPTTSTISSPTS 1175
Query: 264 AVTSTSSHSIGTLAASKIF*TATVISGPIPCPGMSVT 154
+ TST S + A S T+ + P P P S T
Sbjct: 1176 STTSTPQTSKTSAATSST--TSGSGTTPSPVPTTSTT 1210
>UniRef50_O59395 Cluster: Putative uncharacterized protein PH1723;
n=1; Pyrococcus horikoshii|Rep: Putative uncharacterized
protein PH1723 - Pyrococcus horikoshii
Length = 122
Score = 36.3 bits (80), Expect = 0.98
Identities = 31/78 (39%), Positives = 40/78 (51%)
Frame = -2
Query: 630 LLFSLANWKANSATLVLASSVISLMDCTTPSTISCSIPEYSPSVFSLIVTTSTLSYSVLI 451
+L S A++ AN A L VI L T + + S P YSPS+FSL + S L+ I
Sbjct: 1 MLLSFASFTANLAILSAPFLVIILKSTTLLLSYAPS-PLYSPSLFSLTIIISFLNLKFGI 59
Query: 450 PSKLLQGLTLAYKSNSFL 397
L AYKS+SFL
Sbjct: 60 I------LRFAYKSSSFL 71
>UniRef50_Q0P4K8 Cluster: NFATC2-interacting protein; n=1; Xenopus
tropicalis|Rep: NFATC2-interacting protein - Xenopus
tropicalis (Western clawed frog) (Silurana tropicalis)
Length = 434
Score = 36.3 bits (80), Expect = 0.98
Identities = 24/70 (34%), Positives = 32/70 (45%)
Frame = +2
Query: 2 GRPMPPPPPFTASYRSSSQFAKILEMAARIIRKIVPATRAGAAQYSTGVRKVTLIPGHGI 181
G P PPP P T R + KI EM AR +R + T Q T ++ G
Sbjct: 217 GSPSPPPTPKTPVRRKGRAYNKIREMDAR-LRDL--GTVLSPGQKVTTEENDVIVVGSSP 273
Query: 182 GPEITVAVQK 211
PE+TV V++
Sbjct: 274 APELTVKVRR 283
>UniRef50_Q2Q0B6 Cluster: Putative 3-isopropylmalate dehydrogenase;
n=1; uncultured organism HF10_3D09|Rep: Putative
3-isopropylmalate dehydrogenase - uncultured organism
HF10_3D09
Length = 175
Score = 35.5 bits (78), Expect = 1.7
Identities = 19/67 (28%), Positives = 35/67 (52%)
Frame = +2
Query: 653 KANIMRMSXGLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPNLYGDIM 832
K+N+ R LF R +A + ++ + Y+ + + P +DV+V N++GDI
Sbjct: 1 KSNVTR-GCQLFRRTFDAVAASHAHVEKDYGYIDAFTQWLTRTPEFYDVVVTSNMFGDIA 59
Query: 833 SDMCSGL 853
+D+ S L
Sbjct: 60 TDLASVL 66
>UniRef50_Q6AGK4 Cluster: Putative uncharacterized protein; n=1;
Leifsonia xyli subsp. xyli|Rep: Putative uncharacterized
protein - Leifsonia xyli subsp. xyli
Length = 257
Score = 35.1 bits (77), Expect = 2.3
Identities = 31/123 (25%), Positives = 58/123 (47%), Gaps = 4/123 (3%)
Frame = -2
Query: 600 NSATLVLASSVISLMDCTTPSTISCSIPEYSPSVFSLIVTTSTLSYS--VLIPSKLLQGL 427
NSA V A++ + ++ P ++ + P SP+ L++ STL+ S +++ L L
Sbjct: 48 NSARTVAAAAAMGVLVSGFPLLLTVTSPHASPTALGLLLLVSTLTRSPLIVVAMALQSYL 107
Query: 426 TLAYKSNSFLRAKLSDL--*PLPTGVIRGPFKPILLAFTESIAFWGIPNLPSGPLTAVTS 253
+ ++ + R LS L L G + G +L S+ F G P P+ + + +
Sbjct: 108 IVFFRQSPNPRRALSALLGLALAAGGVLGVLGLLLGEAVFSLLFPGQPVPPAWLIAVLVA 167
Query: 252 TSS 244
TS+
Sbjct: 168 TSA 170
>UniRef50_Q6JAD6 Cluster: Putative uncharacterized protein; n=1; Zea
mays|Rep: Putative uncharacterized protein - Zea mays
(Maize)
Length = 725
Score = 35.1 bits (77), Expect = 2.3
Identities = 18/62 (29%), Positives = 32/62 (51%)
Frame = -2
Query: 354 IRGPFKPILLAFTESIAFWGIPNLPSGPLTAVTSTSSHSIGTLAASKIF*TATVISGPIP 175
+ P +P+ LAFT + P P P +AV ST++ ++ A++ + A +S +P
Sbjct: 627 VTSPLRPVTLAFTSPVLSSVCPQPPVPPASAV-STTAVAVSVTASAPVAPAALPVSESVP 685
Query: 174 CP 169
P
Sbjct: 686 AP 687
>UniRef50_A5FB87 Cluster: Von Willebrand factor, type A precursor;
n=1; Flavobacterium johnsoniae UW101|Rep: Von Willebrand
factor, type A precursor - Flavobacterium johnsoniae
UW101
Length = 2588
Score = 34.3 bits (75), Expect = 4.0
Identities = 18/60 (30%), Positives = 29/60 (48%)
Frame = -2
Query: 615 ANWKANSATLVLASSVISLMDCTTPSTISCSIPEYSPSVFSLIVTTSTLSYSVLIPSKLL 436
AN A + TL AS V +CT +T+ + PEY+ + I+ T + +P L+
Sbjct: 1646 ANLPAGTYTLTAASPVSETQNCTASTTVVITQPEYTVKISGHIINVDTHTGIANVPVTLI 1705
>UniRef50_A3DDD4 Cluster: Phage integrase; n=5; Clostridia|Rep:
Phage integrase - Clostridium thermocellum (strain ATCC
27405 / DSM 1237)
Length = 330
Score = 34.3 bits (75), Expect = 4.0
Identities = 19/54 (35%), Positives = 27/54 (50%), Gaps = 4/54 (7%)
Frame = +2
Query: 317 VNANKIGLKGPLMTPVGKGYRS----LNLALRKEFDLYANVRPCKSLEGIKTLY 466
VN N +K ++T VGKG + LN A +K D Y VRP ++ L+
Sbjct: 177 VNINLSNIKNDVLTVVGKGNKERTIYLNAACKKALDAYLKVRPVDGVKDKNALF 230
>UniRef50_A7PLS7 Cluster: Chromosome chr14 scaffold_21, whole genome
shotgun sequence; n=4; core eudicotyledons|Rep:
Chromosome chr14 scaffold_21, whole genome shotgun
sequence - Vitis vinifera (Grape)
Length = 252
Score = 34.3 bits (75), Expect = 4.0
Identities = 18/45 (40%), Positives = 25/45 (55%)
Frame = +2
Query: 680 GLFLRCCRELATKYPDIKFEXRYLXTVCLNMVQDPSKFDVLVMPN 814
GL +RC ELAT+YP KF + + T C+ D + +LV N
Sbjct: 136 GLLMRCLEELATRYPATKF-VKIISTDCIPNYPDRNLPTLLVYNN 179
>UniRef50_A2TU03 Cluster: Ribonuclease HII; n=1; Dokdonia
donghaensis MED134|Rep: Ribonuclease HII - Dokdonia
donghaensis MED134
Length = 818
Score = 33.9 bits (74), Expect = 5.2
Identities = 22/64 (34%), Positives = 35/64 (54%), Gaps = 4/64 (6%)
Frame = -2
Query: 588 LVLASSVISLMDCTTPSTISCSIPEYSPSVFSLIVTTSTLS--YSVLIPSKLLQ--GLTL 421
L L++ V+ L CTT + S S+ +Y P S++V T+ L S L+ + +Q G T
Sbjct: 5 LYLSAVVVLLASCTTSTKNSSSLTKYIPRKASVVVKTTDLKDFKSALVNNDFIQELGTTS 64
Query: 420 AYKS 409
YK+
Sbjct: 65 LYKT 68
>UniRef50_Q7RB56 Cluster: Fulmal1; n=2; Plasmodium (Vinckeia)|Rep:
Fulmal1 - Plasmodium yoelii yoelii
Length = 835
Score = 33.9 bits (74), Expect = 5.2
Identities = 11/22 (50%), Positives = 16/22 (72%)
Frame = +1
Query: 61 CENS*NGCKNNQENCASDQSRR 126
C+N NGCKN + NC +DQ+ +
Sbjct: 213 CKNGENGCKNGEHNCKNDQNSK 234
>UniRef50_A7SWW3 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 441
Score = 33.9 bits (74), Expect = 5.2
Identities = 24/65 (36%), Positives = 35/65 (53%)
Frame = -2
Query: 597 SATLVLASSVISLMDCTTPSTISCSIPEYSPSVFSLIVTTSTLSYSVLIPSKLLQGLTLA 418
+A ++L SSVI + P++ SIP + + IVT +TL Y L+P L+ LT A
Sbjct: 307 AALIILFSSVIYYSESVDPNSNFTSIPA---TFWYTIVTMTTLGYGDLVPESLVGRLTGA 363
Query: 417 YKSNS 403
S S
Sbjct: 364 LCSLS 368
>UniRef50_Q2UNH1 Cluster: Predicted protein; n=2;
Trichocomaceae|Rep: Predicted protein - Aspergillus
oryzae
Length = 238
Score = 33.9 bits (74), Expect = 5.2
Identities = 32/145 (22%), Positives = 63/145 (43%), Gaps = 8/145 (5%)
Frame = +2
Query: 233 PIEWEEVDVTAVRGPDGKFGIPQKAID--SVNANKIGLKGPLMTPVGKGYRSLNL-ALRK 403
P+E VD++ V GP G P+ +D S + P ++P + S NL A R
Sbjct: 94 PVEVSSVDISPVEGPSSP-GAPEMTMDPSSPGGFSVSPVFPPLSPAVESNGSRNLDAERT 152
Query: 404 EFDLYANVRPCKSLEGIKT-LYDNVDV----VTIRENTEGEYSGIEHEIVDGVVQSIKLI 568
FD+ + P S +++ L D D+ + + +N+ +G +H I + +
Sbjct: 153 SFDVGSADTPTWSDASLRSYLDDESDIRDLFIIVHDNSNVPPAGPDHPITGSLFKEESKR 212
Query: 569 TEEASTRVAEFAFQFARENKRKKVT 643
+E ++++ + RK ++
Sbjct: 213 LKEMNSQLDSMLADWVGRKMRKSIS 237
>UniRef50_A5DW24 Cluster: Putative uncharacterized protein; n=2;
Saccharomycetales|Rep: Putative uncharacterized protein -
Lodderomyces elongisporus (Yeast) (Saccharomyces
elongisporus)
Length = 1274
Score = 33.9 bits (74), Expect = 5.2
Identities = 18/60 (30%), Positives = 35/60 (58%), Gaps = 1/60 (1%)
Frame = -1
Query: 439 LARSDISIQVKLLPEGQVE*SVA-FTDWSHQGTLQANFIGIYRVNRFLGNTEFAIWTPNS 263
+ R ++ +Q+KLL + + E S+A +T+W + Q ++I +++F GN WT +S
Sbjct: 1189 IKRHELLVQLKLLNKMEKEISMAEYTNWLYAEVQQCDYIQESILSQFSGNNPRGDWTESS 1248
>UniRef50_Q9RA19 Cluster: ORF10; n=1; Moritella marina|Rep: ORF10 -
Vibrio marinus (Moritella marina)
Length = 2011
Score = 33.5 bits (73), Expect = 6.9
Identities = 17/48 (35%), Positives = 26/48 (54%), Gaps = 2/48 (4%)
Frame = +2
Query: 461 LYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEE--ASTRVAE 598
+YD D+V E G+ G E+ I+DG + ++L T + TRV E
Sbjct: 1156 IYDQADLVEFAEGDIGKVFGAEYNIIDGYSRRVRLPTSDYLLVTRVTE 1203
>UniRef50_Q1QFN8 Cluster: Glycosidase, PH1107-related; n=2;
Bradyrhizobiaceae|Rep: Glycosidase, PH1107-related -
Nitrobacter hamburgensis (strain X14 / DSM 10229)
Length = 373
Score = 33.5 bits (73), Expect = 6.9
Identities = 21/63 (33%), Positives = 32/63 (50%), Gaps = 3/63 (4%)
Frame = +2
Query: 233 PIEWEEV-DVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGK--GYRSLNLALRK 403
P+E E V + A RGPDG+ + + + N ++IG+ L +G G L +AL
Sbjct: 20 PLEAEGVLNPAAARGPDGQLYLFPRLVARGNHSRIGIARVLFNEIGDPVGVERLGIALEP 79
Query: 404 EFD 412
E D
Sbjct: 80 EMD 82
>UniRef50_A7R2H9 Cluster: Chromosome undetermined scaffold_430,
whole genome shotgun sequence; n=1; Vitis vinifera|Rep:
Chromosome undetermined scaffold_430, whole genome
shotgun sequence - Vitis vinifera (Grape)
Length = 84
Score = 33.5 bits (73), Expect = 6.9
Identities = 20/71 (28%), Positives = 31/71 (43%)
Frame = +2
Query: 518 GIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMRMSXGLFLRC 697
G+ + +DG IK E+ + E + N+ KK++ K + M G F RC
Sbjct: 15 GVHYSPLDGSDIQIKTSEEQDPCKNKEIKIESKLHNQLKKISGKKKEESLAMK-GTFRRC 73
Query: 698 CRELATKYPDI 730
C + T P I
Sbjct: 74 CLQSVTCNPHI 84
>UniRef50_Q2VF40 Cluster: Isocitrate dehydrogenase 3 gamma subunit;
n=1; Pan troglodytes|Rep: Isocitrate dehydrogenase 3
gamma subunit - Pan troglodytes (Chimpanzee)
Length = 165
Score = 33.5 bits (73), Expect = 6.9
Identities = 15/31 (48%), Positives = 22/31 (70%)
Frame = +2
Query: 125 AAQYSTGVRKVTLIPGHGIGPEITVAVQKIF 217
+A+Y G VT+IPG GIGPE+ + V+ +F
Sbjct: 106 SAKYG-GRHTVTMIPGDGIGPELMLHVKSVF 135
>UniRef50_UPI0000D5678D Cluster: PREDICTED: similar to CG33087-PC;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG33087-PC - Tribolium castaneum
Length = 1872
Score = 33.1 bits (72), Expect = 9.1
Identities = 17/47 (36%), Positives = 26/47 (55%), Gaps = 1/47 (2%)
Frame = +1
Query: 40 LPLVFAICENS*NGCKNNQENCASDQSRRCSVQHWR-AQGYAHPWTW 177
+P V+ +C+ N C +N + QSR CS QH+R + G P +W
Sbjct: 776 IPAVW-VCDTD-NDCGDNSDEQQDCQSRTCSPQHYRCSSGRCIPMSW 820
>UniRef50_Q8D4B1 Cluster: Putative uncharacterized protein; n=2;
Vibrio vulnificus|Rep: Putative uncharacterized protein
- Vibrio vulnificus
Length = 1222
Score = 33.1 bits (72), Expect = 9.1
Identities = 15/58 (25%), Positives = 35/58 (60%)
Frame = +2
Query: 467 DNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKV 640
D + VT+ + T+GE + + ++ VV K+ ++A+T V ++A++ E +R+++
Sbjct: 527 DTIQYVTVTQGTDGELASVTTQLDQFVVNGFKI--DDATTHVKDYAYR-GVEKRREQI 581
>UniRef50_Q5NXI3 Cluster: Putative uncharacterized protein; n=1;
Azoarcus sp. EbN1|Rep: Putative uncharacterized protein
- Azoarcus sp. (strain EbN1) (Aromatoleum aromaticum
(strain EbN1))
Length = 1082
Score = 33.1 bits (72), Expect = 9.1
Identities = 15/52 (28%), Positives = 27/52 (51%)
Frame = +2
Query: 8 PMPPPPPFTASYRSSSQFAKILEMAARIIRKIVPATRAGAAQYSTGVRKVTL 163
P+P P + +YR+ + ++L+ + + P+ AG Y+TG VTL
Sbjct: 323 PIPAPGTLSVAYRAQDNWYELLDNGSGQLVGSDPSIGAGTINYTTGAMSVTL 374
>UniRef50_Q1D919 Cluster: Putative uncharacterized protein; n=1;
Myxococcus xanthus DK 1622|Rep: Putative uncharacterized
protein - Myxococcus xanthus (strain DK 1622)
Length = 476
Score = 33.1 bits (72), Expect = 9.1
Identities = 26/100 (26%), Positives = 40/100 (40%), Gaps = 1/100 (1%)
Frame = +2
Query: 2 GRPMPPPPPFTASYRSSSQFAKILEMAARIIRKIVPATRAGAAQYSTGVRKVTLIPGHGI 181
G P+ PP S A L+ + R VPAT G + +T + T +PG +
Sbjct: 258 GAPVTASPPPAPSAIGGGGTAGALQDTGAVTRVTVPATAPG--RLATAPVQTTTVPGVPV 315
Query: 182 GPEITVAVQKIFEAAKVPIEWE-EVDVTAVRGPDGKFGIP 298
PEI + P+ + ++ VT + G G P
Sbjct: 316 TPEIISGGLPVPMVTNTPVTYSGQLPVTPLDGTTVVAGTP 355
>UniRef50_A6DSS2 Cluster: NOL1/NOP2/sun family putative RNA
methylase; n=1; Lentisphaera araneosa HTCC2155|Rep:
NOL1/NOP2/sun family putative RNA methylase -
Lentisphaera araneosa HTCC2155
Length = 434
Score = 33.1 bits (72), Expect = 9.1
Identities = 28/110 (25%), Positives = 49/110 (44%), Gaps = 1/110 (0%)
Frame = -2
Query: 816 KLGITSTSNLEGSCTMLRQTVXRYRXSNLMSGYLVASSRQQRRKRPXDIRIILALCTAVT 637
K GITST E L++ R R SN+ + L +R +KRP D ++ A C+
Sbjct: 270 KGGITSTDIREWKLDDLKKRARRARFSNITTKNL-KKTRSASKKRPYDGVLVDAPCSCTG 328
Query: 636 FFLLFSLANWKANSATL-VLASSVISLMDCTTPSTISCSIPEYSPSVFSL 490
+ A W + + LA+ +++ + P + + Y+ FS+
Sbjct: 329 TWRRNPDARWSSTAKDCEELATIQADILEKSAPGVKADGVLVYATCSFSV 378
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 853,228,741
Number of Sequences: 1657284
Number of extensions: 17933530
Number of successful extensions: 73168
Number of sequences better than 10.0: 151
Number of HSP's better than 10.0 without gapping: 65484
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 72525
length of database: 575,637,011
effective HSP length: 100
effective length of database: 409,908,611
effective search space used: 75013275813
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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