Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fcaL-P04_F_F20
(790 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q9XYB0 Cluster: PugilistDominant; n=2; Coelomata|Rep: P... 213 6e-54
UniRef50_UPI00015B59A5 Cluster: PREDICTED: similar to ENSANGP000... 196 4e-49
UniRef50_P11586 Cluster: C-1-tetrahydrofolate synthase, cytoplas... 177 3e-43
UniRef50_Q4T2B9 Cluster: Chromosome undetermined SCAF10300, whol... 148 2e-34
UniRef50_Q21285 Cluster: Dauer or aging adult overexpression pro... 132 1e-29
UniRef50_O65271 Cluster: F6N23.26 protein; n=20; Viridiplantae|R... 123 6e-27
UniRef50_Q9LHH7 Cluster: 5,10-methylenetetrahydrofolate dehydrog... 119 1e-25
UniRef50_Q5IWX9 Cluster: Plastid 5,10-methylene-tetrahydrofolate... 116 5e-25
UniRef50_O84081 Cluster: Bifunctional protein folD [Includes: Me... 116 5e-25
UniRef50_Q8KN38 Cluster: Bifunctional protein folD [Includes: Me... 113 4e-24
UniRef50_Q5PBL6 Cluster: Bifunctional protein folD [Includes: Me... 111 2e-23
UniRef50_Q7MVE9 Cluster: Bifunctional protein folD [Includes: Me... 108 2e-22
UniRef50_A1AL91 Cluster: Bifunctional protein folD [Includes: Me... 107 2e-22
UniRef50_Q24UZ7 Cluster: Bifunctional protein folD 2 [Includes: ... 107 2e-22
UniRef50_Q8DMU0 Cluster: Bifunctional protein folD [Includes: Me... 107 4e-22
UniRef50_Q4FNW1 Cluster: Bifunctional protein folD [Includes: Me... 107 4e-22
UniRef50_Q63SL6 Cluster: Bifunctional protein folD [Includes: Me... 107 4e-22
UniRef50_Q8TK95 Cluster: Bifunctional protein folD [Includes: Me... 105 1e-21
UniRef50_Q16F77 Cluster: Methylenetetrahydrofolate dehydrogenase... 103 4e-21
UniRef50_Q0AZF5 Cluster: Bifunctional protein folD 1 [Includes: ... 103 5e-21
UniRef50_Q6F9E6 Cluster: Bifunctional protein folD 1 [Includes: ... 103 5e-21
UniRef50_Q1II76 Cluster: Bifunctional protein folD [Includes: Me... 103 7e-21
UniRef50_Q8EQ43 Cluster: Bifunctional protein folD [Includes: Me... 102 9e-21
UniRef50_Q9A8Y0 Cluster: Bifunctional protein folD [Includes: Me... 102 9e-21
UniRef50_Q6BNW9 Cluster: Debaryomyces hansenii chromosome E of s... 101 2e-20
UniRef50_Q83FS2 Cluster: Bifunctional protein folD [Includes: Me... 101 2e-20
UniRef50_Q9ZD32 Cluster: Bifunctional protein folD [Includes: Me... 100 4e-20
UniRef50_Q3YRE3 Cluster: Bifunctional protein folD [Includes: Me... 100 5e-20
UniRef50_P13995 Cluster: Bifunctional methylenetetrahydrofolate ... 98 2e-19
UniRef50_A0JTZ0 Cluster: Bifunctional protein folD [Includes: Me... 98 2e-19
UniRef50_A7D6I9 Cluster: Methenyltetrahydrofolate cyclohydrolase... 97 3e-19
UniRef50_Q6ALZ5 Cluster: Bifunctional protein folD [Includes: Me... 97 6e-19
UniRef50_UPI000038C811 Cluster: COG0190: 5,10-methylene-tetrahyd... 96 1e-18
UniRef50_A5CF58 Cluster: Bifunctional protein folD [Includes: Me... 95 2e-18
UniRef50_Q54VK0 Cluster: Methenyl tetrahydrofolate cyclohydrolas... 94 3e-18
UniRef50_P56467 Cluster: Bifunctional protein folD [Includes: Me... 94 3e-18
UniRef50_Q9HPY4 Cluster: Bifunctional protein folD [Includes: Me... 94 3e-18
UniRef50_Q189R8 Cluster: Bifunctional protein folD [Includes: Me... 94 4e-18
UniRef50_Q86F84 Cluster: Clone ZZD1003 mRNA sequence; n=1; Schis... 93 5e-18
UniRef50_Q6F1V0 Cluster: Bifunctional protein folD [Includes: Me... 93 1e-17
UniRef50_A4EAK0 Cluster: Putative uncharacterized protein; n=3; ... 92 2e-17
UniRef50_O83714 Cluster: Bifunctional protein folD [Includes: Me... 92 2e-17
UniRef50_Q4RT28 Cluster: Chromosome 12 SCAF14999, whole genome s... 91 4e-17
UniRef50_Q8RAD0 Cluster: Bifunctional protein folD [Includes: Me... 91 4e-17
UniRef50_Q4FTX6 Cluster: Bifunctional protein folD [Includes: Me... 91 4e-17
UniRef50_A7DNA7 Cluster: Methylenetetrahydrofolate dehydrogenase... 90 5e-17
UniRef50_UPI00015B49ED Cluster: PREDICTED: similar to putative g... 90 7e-17
UniRef50_Q5SJ94 Cluster: Bifunctional protein folD [Includes: Me... 89 9e-17
UniRef50_Q2B9L0 Cluster: Bifunctional protein FolD; n=1; Bacillu... 89 1e-16
UniRef50_Q3AYX2 Cluster: Bifunctional protein folD [Includes: Me... 89 1e-16
UniRef50_A3PVV6 Cluster: Bifunctional protein folD [Includes: Me... 87 4e-16
UniRef50_Q3A1Q7 Cluster: Bifunctional protein folD [Includes: Me... 87 6e-16
UniRef50_A1HML1 Cluster: Methenyltetrahydrofolate cyclohydrolase... 86 8e-16
UniRef50_Q74GN1 Cluster: Bifunctional protein folD 1 [Includes: ... 86 8e-16
UniRef50_Q6D2E6 Cluster: Bifunctional protein folD [Includes: Me... 86 1e-15
UniRef50_UPI000065DF90 Cluster: methylenetetrahydrofolate dehydr... 85 2e-15
UniRef50_Q5FJG5 Cluster: Bifunctional protein folD [Includes: Me... 85 3e-15
UniRef50_Q74J95 Cluster: Bifunctional protein folD 1 [Includes: ... 85 3e-15
UniRef50_Q97HC9 Cluster: Bifunctional protein folD [Includes: Me... 84 4e-15
UniRef50_Q0AWX5 Cluster: Bifunctional protein folD 2 [Includes: ... 84 4e-15
UniRef50_Q9KQQ6 Cluster: Bifunctional protein folD [Includes: Me... 83 6e-15
UniRef50_Q4S6Y9 Cluster: Chromosome 14 SCAF14723, whole genome s... 83 1e-14
UniRef50_Q14NV1 Cluster: Bifunctional protein folD [Includes: Me... 82 2e-14
UniRef50_A5V1H2 Cluster: Methylenetetrahydrofolate dehydrogenase... 80 5e-14
UniRef50_O65269 Cluster: F6N23.28 protein; n=1; Arabidopsis thal... 79 1e-13
UniRef50_O51057 Cluster: Bifunctional protein folD [Includes: Me... 79 2e-13
UniRef50_UPI00006CCCC6 Cluster: methylenetetrahydrofolate dehydr... 78 2e-13
UniRef50_UPI00006CB712 Cluster: tetrahydrofolate dehydrogenase/c... 78 3e-13
UniRef50_Q0SFQ8 Cluster: Bifunctional protein folD 1 [Includes: ... 78 3e-13
UniRef50_Q987T6 Cluster: Bifunctional protein folD 2 [Includes: ... 77 5e-13
UniRef50_UPI0000DB7ABF Cluster: PREDICTED: similar to Bifunction... 76 1e-12
UniRef50_Q6MI74 Cluster: Bifunctional protein folD [Includes: Me... 76 1e-12
UniRef50_Q5RGD2 Cluster: Novel protein similar to vertebrate for... 75 2e-12
UniRef50_Q4A6B1 Cluster: Bifunctional protein folD [Includes: Me... 74 4e-12
UniRef50_A5IXS7 Cluster: FolD bifunctional protein; n=1; Mycopla... 74 5e-12
UniRef50_A0DMT9 Cluster: Chromosome undetermined scaffold_57, wh... 73 1e-11
UniRef50_P47259 Cluster: Bifunctional protein folD [Includes: Me... 72 1e-11
UniRef50_Q7TU81 Cluster: Bifunctional protein folD [Includes: Me... 71 3e-11
UniRef50_Q04FB7 Cluster: Bifunctional protein folD [Includes: Me... 71 3e-11
UniRef50_Q6KID0 Cluster: Bifunctional protein folD [Includes: Me... 71 3e-11
UniRef50_Q979W3 Cluster: Bifunctional protein folD [Includes: Me... 71 3e-11
UniRef50_Q057D7 Cluster: Bifunctional protein folD [Includes: Me... 67 4e-10
UniRef50_A0C3Q0 Cluster: Chromosome undetermined scaffold_147, w... 67 5e-10
UniRef50_Q4DH06 Cluster: Methylenetetrahydrofolate dehydrogenase... 66 7e-10
UniRef50_Q9RW02 Cluster: Bifunctional protein folD [Includes: Me... 66 7e-10
UniRef50_Q8RDM4 Cluster: Bifunctional protein folD [Includes: Me... 65 2e-09
UniRef50_Q1AVQ0 Cluster: Bifunctional protein folD 2 [Includes: ... 64 3e-09
UniRef50_A7AXK7 Cluster: Putative uncharacterized protein; n=1; ... 62 2e-08
UniRef50_Q8ZZK1 Cluster: Bifunctional protein folD [Includes: Me... 61 4e-08
UniRef50_Q8EV80 Cluster: Bifunctional protein folD [Includes: Me... 60 5e-08
UniRef50_Q4QBW1 Cluster: Methylenetetrahydrofolate dehydrogenase... 60 6e-08
UniRef50_Q9X288 Cluster: Bifunctional protein folD [Includes: Me... 60 6e-08
UniRef50_Q6L046 Cluster: Bifunctional protein folD [Includes: Me... 56 1e-06
UniRef50_Q2JCX4 Cluster: Bifunctional protein folD 1 [Includes: ... 55 2e-06
UniRef50_Q6X5D4 Cluster: Methylene-THF dehydrogenase; n=1; Trepo... 51 4e-05
UniRef50_A4M873 Cluster: Tetrahydrofolate dehydrogenase/cyclohyd... 49 1e-04
UniRef50_Q98QV3 Cluster: Bifunctional protein folD [Includes: Me... 48 4e-04
UniRef50_Q2UUX1 Cluster: RIB40 genomic DNA, SC009; n=1; Aspergil... 47 5e-04
UniRef50_Q5KEZ0 Cluster: Methylenetetrahydrofolate dehydrogenase... 46 0.001
UniRef50_Q54Z91 Cluster: Methylenetetrahydrofolate dehydrogenase... 45 0.002
UniRef50_Q4VDG8 Cluster: Putative methylene tetrahydrofolate deh... 44 0.006
UniRef50_Q8W528 Cluster: Methylenetetrahydrofolate dehydrogenase... 42 0.018
UniRef50_Q8KEH0 Cluster: Methylenetetrahydrofolate dehydrogenase... 37 0.66
UniRef50_A6RR95 Cluster: Putative uncharacterized protein; n=1; ... 35 2.0
UniRef50_Q96Q89-2 Cluster: Isoform 2 of Q96Q89 ; n=1; Homo sapie... 34 4.7
UniRef50_Q4S5A6 Cluster: Chromosome 19 SCAF14731, whole genome s... 34 4.7
UniRef50_Q96Q89 Cluster: M-phase phosphoprotein 1; n=11; Eumetaz... 34 4.7
UniRef50_Q7NAE4 Cluster: Bifunctional protein folD [Includes: Me... 34 4.7
UniRef50_Q1IRB8 Cluster: Putative uncharacterized protein precur... 33 8.2
>UniRef50_Q9XYB0 Cluster: PugilistDominant; n=2; Coelomata|Rep:
PugilistDominant - Drosophila melanogaster (Fruit fly)
Length = 268
Score = 213 bits (519), Expect = 6e-54
Identities = 98/145 (67%), Positives = 118/145 (81%)
Frame = +3
Query: 354 AVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHI 533
AV +SI +LR +VT + + + F P L IVQVGGREDSNVYIRMK+KAA +IGI A H+
Sbjct: 11 AVAKSIREELRNEVTAMSKQLADFVPGLRIVQVGGREDSNVYIRMKIKAATEIGIDAAHV 70
Query: 534 RLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTI 713
+LPR ITE+ELL KI LNE P VHGIIVQMPLD D ID+HR+TDAVSP+KDVDGL+T+
Sbjct: 71 QLPRSITEVELLDKINDLNEDPRVHGIIVQMPLDCDTPIDSHRITDAVSPEKDVDGLHTV 130
Query: 714 NEGRVXVGDLSGFIPCTPXGCVELI 788
NEGR+ +GDL GF+PCTP GC+ELI
Sbjct: 131 NEGRLAIGDLGGFLPCTPWGCLELI 155
>UniRef50_UPI00015B59A5 Cluster: PREDICTED: similar to
ENSANGP00000016878; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000016878 - Nasonia
vitripennis
Length = 866
Score = 196 bits (479), Expect = 4e-49
Identities = 89/142 (62%), Positives = 108/142 (76%)
Frame = +3
Query: 363 ESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLP 542
+ I L + V ++ K + P LAIVQVGGREDSNVYIRMK+KAA +IGI A H+++P
Sbjct: 17 KEIRESLAKDVAAIQQKLPNYAPGLAIVQVGGREDSNVYIRMKIKAASEIGIKATHVKMP 76
Query: 543 RDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEG 722
TE ELL K+ LN P HGIIVQMPLDS + I++H +TD VSPDKDVDGLNTINEG
Sbjct: 77 NTTTEHELLTKLNKLNNDPDTHGIIVQMPLDSVNKINSHLITDTVSPDKDVDGLNTINEG 136
Query: 723 RVXVGDLSGFIPCTPXGCVELI 788
RV +GD+SGF+PCTP GC+ELI
Sbjct: 137 RVAIGDMSGFLPCTPNGCIELI 158
>UniRef50_P11586 Cluster: C-1-tetrahydrofolate synthase, cytoplasmic
(C1-THF synthase) [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate
synthetase (EC 6.3.4.3)]; n=86; cellular organisms|Rep:
C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF
synthase) [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate
synthetase (EC 6.3.4.3)] - Homo sapiens (Human)
Length = 935
Score = 177 bits (430), Expect = 3e-43
Identities = 86/152 (56%), Positives = 115/152 (75%), Gaps = 1/152 (0%)
Frame = +3
Query: 336 NSEELEAVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIG 515
N +E+ A I L+ QVT+L+ + GF PRLAI+QVG R+DSN+YI +KLKAAE+IG
Sbjct: 8 NGKEISA---QIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEIG 64
Query: 516 IAAEHIRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDV 695
I A HI+LPR TE E++ ITSLNE +VHG +VQ+PLDS+++I+ V +A++P+KDV
Sbjct: 65 IKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKDV 124
Query: 696 DGLNTINEGRVXVGDLSG-FIPCTPXGCVELI 788
DGL +IN GR+ GDL+ FIPCTP GC+ELI
Sbjct: 125 DGLTSINAGRLARGDLNDCFIPCTPKGCLELI 156
>UniRef50_Q4T2B9 Cluster: Chromosome undetermined SCAF10300, whole
genome shotgun sequence; n=6; Clupeocephala|Rep:
Chromosome undetermined SCAF10300, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 348
Score = 148 bits (358), Expect = 2e-34
Identities = 75/137 (54%), Positives = 98/137 (71%), Gaps = 1/137 (0%)
Frame = +3
Query: 381 LRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEI 560
L Q++ RL S F + ++QVG R+DSN+YI K+KAA +IGI A+H+RLP T+
Sbjct: 68 LGQKLLRLLVLTSVF--LVTLLQVGDRDDSNLYISAKMKAAAEIGIDAKHVRLPSSATQE 125
Query: 561 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 740
E+L I S+NE SVHG+IVQ+PLDS H ID+ +T+ VS DKDVDGL+ IN GR+ GD
Sbjct: 126 EVLLNILSINEDQSVHGLIVQLPLDSVHHIDSECITNTVSADKDVDGLSCINAGRLSRGD 185
Query: 741 LSG-FIPCTPXGCVELI 788
L F+PCTP GC+ELI
Sbjct: 186 LDACFLPCTPSGCLELI 202
>UniRef50_Q21285 Cluster: Dauer or aging adult overexpression
protein 3; n=2; Caenorhabditis|Rep: Dauer or aging adult
overexpression protein 3 - Caenorhabditis elegans
Length = 303
Score = 132 bits (318), Expect = 1e-29
Identities = 67/143 (46%), Positives = 90/143 (62%), Gaps = 1/143 (0%)
Frame = +3
Query: 363 ESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLP 542
+ + +D+ Q++ + R F LAIVQVG R DSNVYI KLK A++IG + I+LP
Sbjct: 13 KKVLHDVGQKIAKTREHHPNFHAVLAIVQVGNRSDSNVYINSKLKKAKEIGADGKLIKLP 72
Query: 543 RDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEG 722
IT+ +L +I +LN + GII+Q+PLD H IDA V D + P KDVDGL IN G
Sbjct: 73 DTITQGDLKREIMALNHDNEIDGIIIQLPLDCKHEIDADSVIDLIDPLKDVDGLTRINAG 132
Query: 723 RVXVGDLSGFI-PCTPXGCVELI 788
R+ G+L I PCTP GC+ L+
Sbjct: 133 RLARGELQRTIFPCTPFGCLYLV 155
>UniRef50_O65271 Cluster: F6N23.26 protein; n=20; Viridiplantae|Rep:
F6N23.26 protein - Arabidopsis thaliana (Mouse-ear
cress)
Length = 360
Score = 123 bits (296), Expect = 6e-27
Identities = 61/147 (41%), Positives = 96/147 (65%), Gaps = 1/147 (0%)
Frame = +3
Query: 351 EAVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEH 530
+AV + I +++ +V+R++ G P LA++ VG R+DS Y+R K KA + +GI +
Sbjct: 75 KAVAKKIRDEITIEVSRMKES-IGVIPGLAVILVGDRKDSATYVRNKKKACDSVGIKSFE 133
Query: 531 IRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 710
+RL D +E E+L ++ N+ PSVHGI+VQ+PL S +D + +AVS +KDVDG +
Sbjct: 134 VRLAEDSSEEEVLKSVSGFNDDPSVHGILVQLPLPSH--MDEQNILNAVSIEKDVDGFHP 191
Query: 711 INEGRVXV-GDLSGFIPCTPXGCVELI 788
+N GR+ + G F+PCTP GC+EL+
Sbjct: 192 LNIGRLAMRGREPLFVPCTPKGCIELL 218
>UniRef50_Q9LHH7 Cluster: 5,10-methylenetetrahydrofolate
dehydrogenase/5,10- methenyltetrahydrofolate
cyclohydrolase; n=7; Eukaryota|Rep:
5,10-methylenetetrahydrofolate dehydrogenase/5,10-
methenyltetrahydrofolate cyclohydrolase - Arabidopsis
thaliana (Mouse-ear cress)
Length = 299
Score = 119 bits (286), Expect = 1e-25
Identities = 59/147 (40%), Positives = 95/147 (64%), Gaps = 1/147 (0%)
Frame = +3
Query: 351 EAVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEH 530
+A+ +I +++ ++V L K G P LA+V VG R+DS Y+ K KA ++GI +
Sbjct: 15 KAIAHTIRSEIAEEVRGLSEK-HGKVPGLAVVIVGSRKDSQTYVNTKRKACAEVGIKSFD 73
Query: 531 IRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 710
+ LP +++E +L++K+ LN +P VHGI+VQ+PL H + H + A+S DKDVDG +
Sbjct: 74 VGLPEEVSEADLISKVHELNSNPDVHGILVQLPLPK-HINEEH-ILGAISIDKDVDGFHP 131
Query: 711 INEGRVXV-GDLSGFIPCTPXGCVELI 788
+N G++ + G F+PCTP GC+EL+
Sbjct: 132 LNIGKLAMKGREPLFLPCTPKGCLELL 158
>UniRef50_Q5IWX9 Cluster: Plastid 5,10-methylene-tetrahydrofolate
dehydrogenase; n=1; Prototheca wickerhamii|Rep: Plastid
5,10-methylene-tetrahydrofolate dehydrogenase -
Prototheca wickerhamii
Length = 248
Score = 116 bits (280), Expect = 5e-25
Identities = 61/145 (42%), Positives = 94/145 (64%), Gaps = 1/145 (0%)
Frame = +3
Query: 357 VQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIR 536
+ E+I +L+ +V LR++++ P LA+V VG R+DS Y+R K KA +++GI +
Sbjct: 70 IAETIRGELKVEVDELRAQYNTV-PGLAVVLVGERKDSQTYVRSKKKACDEVGINSFGAD 128
Query: 537 LPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 716
LP TE E+LA + N+ P+VHGI+VQ+PL +H I+ RV DA+S +KDVDG + N
Sbjct: 129 LPETATEEEVLAVVAKFNDDPNVHGILVQLPL-PEH-INEKRVLDAISLEKDVDGFHPNN 186
Query: 717 EGRVXV-GDLSGFIPCTPXGCVELI 788
G + + G ++ CTP GC+EL+
Sbjct: 187 IGELAMRGRSPTYVSCTPKGCLELL 211
>UniRef50_O84081 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Chlamydiaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Chlamydia trachomatis
Length = 287
Score = 116 bits (280), Expect = 5e-25
Identities = 52/119 (43%), Positives = 77/119 (64%)
Frame = +3
Query: 429 PRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKITSLNESPSVH 608
P LA+V +G S +Y+ MK+K A +G+ ++ R P D T ++LA I LN ++H
Sbjct: 27 PGLAVVLIGNNPASEIYVNMKIKRATDLGMVSKSYRKPSDATLSDILALIHQLNNDENIH 86
Query: 609 GIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGFIPCTPXGCVEL 785
GI+VQ+PL +DA + ++PDKDVDGL+ +N G++ +G+ GFIPCTP G VEL
Sbjct: 87 GILVQLPLPKH--LDAQAILSTITPDKDVDGLHPVNVGKLLLGETDGFIPCTPAGIVEL 143
>UniRef50_Q8KN38 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Sphingobium chlorophenolicum|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Sphingobium
chlorophenolicum
Length = 316
Score = 113 bits (273), Expect = 4e-24
Identities = 60/145 (41%), Positives = 86/145 (59%)
Frame = +3
Query: 354 AVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHI 533
A E + DL + V R S+ G+ P L V VG S++Y+R K++ K+G+ +
Sbjct: 9 AAAEGLLADLTRDVARF-SQVHGYAPTLVAVLVGDDPASHIYVRKKIEQCRKVGMESVEH 67
Query: 534 RLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTI 713
RLP D +E +LLA I SLN VHGI+VQ+PL + ID+ +V D + P KDVDG + +
Sbjct: 68 RLPADCSEEDLLALIASLNADERVHGILVQLPLPAQ--IDSGKVLDTIDPRKDVDGFHPV 125
Query: 714 NEGRVXVGDLSGFIPCTPXGCVELI 788
N R+ G G +PCTP GC+ L+
Sbjct: 126 NVFRLSTG-TGGLVPCTPMGCMILL 149
>UniRef50_Q5PBL6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Alphaproteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Anaplasma marginale (strain St. Maries)
Length = 299
Score = 111 bits (267), Expect = 2e-23
Identities = 59/144 (40%), Positives = 84/144 (58%)
Frame = +3
Query: 357 VQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIR 536
V + + LR V RL+++ G P L +V VG S +Y+ K + AE++G+ + I
Sbjct: 10 VARGLLDRLRVSVDRLKAE-HGIVPHLVVVIVGDDPASKLYVGNKQRKAEELGLQSRTIA 68
Query: 537 LPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 716
L D ++ ELL I LN +VHGI+VQ+PL ID V +A+SP+KDVDG + N
Sbjct: 69 LEHDTSQEELLRIIDELNRDAAVHGILVQLPLPRH--IDKELVINAISPEKDVDGFHNAN 126
Query: 717 EGRVXVGDLSGFIPCTPXGCVELI 788
G++ G L IPCTP GC+ LI
Sbjct: 127 AGKLATGQLDCMIPCTPQGCIHLI 150
>UniRef50_Q7MVE9 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=52; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Porphyromonas gingivalis (Bacteroides gingivalis)
Length = 296
Score = 108 bits (259), Expect = 2e-22
Identities = 61/144 (42%), Positives = 83/144 (57%)
Frame = +3
Query: 357 VQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIR 536
+ I+ ++ V L K G P LA V VG S Y+ K+KA E++G + IR
Sbjct: 13 ISGEIKQEIAAVVNELLEK-GGRRPHLAGVLVGHDGGSETYMASKVKACEEVGFTSSLIR 71
Query: 537 LPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 716
D+TE ELLA + LN+ P+V G IVQ+PL ID ++ +AV P KDVDG + IN
Sbjct: 72 YEDDVTEEELLACVHRLNQDPTVDGFIVQLPLPKH--IDEQKIIEAVDPRKDVDGFHPIN 129
Query: 717 EGRVXVGDLSGFIPCTPXGCVELI 788
GR+ +G L GF+ TP G VEL+
Sbjct: 130 VGRLSIG-LPGFVSATPKGIVELL 152
>UniRef50_A1AL91 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=9; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Pelobacter propionicus (strain DSM 2379)
Length = 283
Score = 107 bits (258), Expect = 2e-22
Identities = 60/146 (41%), Positives = 85/146 (58%)
Frame = +3
Query: 351 EAVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEH 530
+A+ I +++ V L+ K G P LA+V VG + S VY+ MK KA GI +
Sbjct: 8 KAIAAKIRSEIASGVRELQGK--GVTPGLAVVLVGDDQASRVYVSMKEKACNDAGIFSVE 65
Query: 531 IRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 710
+L + +E ELLA + LN P +HGI+VQ+PL S ID +V +A+SP KDVDG +
Sbjct: 66 HKLAAETSEAELLALVELLNNDPKIHGILVQLPLPSQ--IDTDKVLEAISPFKDVDGFHP 123
Query: 711 INEGRVXVGDLSGFIPCTPXGCVELI 788
N GR+ VG F PCTP G + ++
Sbjct: 124 YNVGRLSVGK-PVFQPCTPYGVMVML 148
>UniRef50_Q24UZ7 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Peptococcaceae|Rep: Bifunctional protein folD 2
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Desulfitobacterium hafniense (strain Y51)
Length = 284
Score = 107 bits (258), Expect = 2e-22
Identities = 56/144 (38%), Positives = 87/144 (60%)
Frame = +3
Query: 357 VQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIR 536
+ + ++ +++++V R + + G P+LA+V VG S VY + K K ++ +GI E
Sbjct: 10 ISKVLKEEIKEEVKRWKEQ--GVNPKLAVVLVGDDPASVVYAKSKQKVSDSLGIDFELTV 67
Query: 537 LPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 716
LP D +E +LA I SLN +P VHGI++++PL I RV AV PDKDVDG++ IN
Sbjct: 68 LPADSSEESILALIDSLNANPDVHGIMIELPLPKH--ISKERVMAAVRPDKDVDGVHPIN 125
Query: 717 EGRVXVGDLSGFIPCTPXGCVELI 788
G + G+ G P TP C+E++
Sbjct: 126 RGYILSGE-EGLFPATPESCIEIM 148
>UniRef50_Q8DMU0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=90; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Synechococcus elongatus (Thermosynechococcus
elongatus)
Length = 306
Score = 107 bits (256), Expect = 4e-22
Identities = 60/146 (41%), Positives = 87/146 (59%)
Frame = +3
Query: 351 EAVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEH 530
+++ +SIE L V +++W G P LA+++VG S VY+R K +A ++GI +
Sbjct: 12 KSLAQSIERQLADHVRTFQAQW-GRSPGLAVLRVGNDPASAVYVRAKEQACSRVGIQSFG 70
Query: 531 IRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 710
LP ITE LLAKIT LN+ V GI++Q+PL +D + A+ PDKDVDGL+
Sbjct: 71 AHLPATITEAALLAKITELNQDERVDGILLQLPLPPH--LDPRPLLYAIHPDKDVDGLHP 128
Query: 711 INEGRVXVGDLSGFIPCTPXGCVELI 788
N GR+ V D G CTP G ++L+
Sbjct: 129 ENLGRL-VRDEPGLRSCTPAGVMQLL 153
>UniRef50_Q4FNW1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Pelagibacter ubique
Length = 281
Score = 107 bits (256), Expect = 4e-22
Identities = 55/144 (38%), Positives = 84/144 (58%)
Frame = +3
Query: 357 VQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIR 536
+ + LRQ+V L++K + P L ++ +G S +Y+RMK KAA ++G+ +E IR
Sbjct: 9 IAAELREQLRQEVVELKAKHNKI-PGLTVILIGEMAPSQIYVRMKEKAANEVGLKSEVIR 67
Query: 537 LPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 716
P + E +L KI LN+ S+ GI+VQ+PL ID +V + + P KDVDG + +N
Sbjct: 68 YPEAVEEKTVLDKIEELNKDESISGILVQLPLPKH--IDKQKVIETILPGKDVDGFHPMN 125
Query: 717 EGRVXVGDLSGFIPCTPXGCVELI 788
G + G S +PCTP GC +I
Sbjct: 126 VGNLSSGYESS-VPCTPLGCYLMI 148
>UniRef50_Q63SL6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=226; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Burkholderia pseudomallei (Pseudomonas
pseudomallei)
Length = 285
Score = 107 bits (256), Expect = 4e-22
Identities = 53/122 (43%), Positives = 76/122 (62%)
Frame = +3
Query: 420 GFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKITSLNESP 599
G P LA++ VG S VY+R K+KA E G + R P ++E ELLA+I LN P
Sbjct: 30 GHRPGLAVILVGDNPASEVYVRNKIKACEDNGFFSLKDRYPATLSEPELLARIDELNRDP 89
Query: 600 SVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGFIPCTPXGCV 779
+HGI+VQ+PL + ID+H+V +A++P+KDVDG + N G + G F PCTP G +
Sbjct: 90 KIHGILVQLPLPAH--IDSHKVIEAIAPEKDVDGFHVANAGALLTGK-PLFRPCTPYGVM 146
Query: 780 EL 785
++
Sbjct: 147 KM 148
>UniRef50_Q8TK95 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Methanosarcina acetivorans
Length = 290
Score = 105 bits (253), Expect = 1e-21
Identities = 54/147 (36%), Positives = 84/147 (57%), Gaps = 1/147 (0%)
Frame = +3
Query: 351 EAVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEH 530
+ + + +E ++R V L S G P LA + VG S +Y+R+K +A E++GI AE
Sbjct: 14 KVLAQQVEEEVRSGVEDLESN-RGIVPGLATILVGDDPASKMYVRLKHRACERVGIKAED 72
Query: 531 IRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHA-IDAHRVTDAVSPDKDVDGLN 707
LP D T+ ELL I SLN++ VH I++Q+PL + + +A+SP KD DG +
Sbjct: 73 YLLPGDATQEELLTLIDSLNKNKDVHAILLQLPLPKHFSPQETQEAMEAISPTKDADGFH 132
Query: 708 TINEGRVXVGDLSGFIPCTPXGCVELI 788
N G++ +GD +PCTP G + +
Sbjct: 133 PYNMGKLMIGD-EDLVPCTPHGVIRAL 158
>UniRef50_Q16F77 Cluster: Methylenetetrahydrofolate dehydrogenase;
n=4; cellular organisms|Rep: Methylenetetrahydrofolate
dehydrogenase - Aedes aegypti (Yellowfever mosquito)
Length = 337
Score = 103 bits (248), Expect = 4e-21
Identities = 57/144 (39%), Positives = 83/144 (57%)
Frame = +3
Query: 357 VQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIR 536
+ I +LR+Q+ + P L + +G SN Y+ K+KAA +GI ++ R
Sbjct: 41 IAADIRMELREQIEEWMKQGGNRAPHLTAILIGEDPASNTYVSNKMKAAADVGITSKTER 100
Query: 537 LPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 716
DITE +LL +I LN+ SV GI+VQ+P+ I+ +V ++VS DKDVDG N N
Sbjct: 101 YSADITEEQLLKRIEELNQDDSVDGILVQLPVPGH--INERKVCNSVSCDKDVDGFNERN 158
Query: 717 EGRVXVGDLSGFIPCTPXGCVELI 788
GR+ + D++ IPCTP G ELI
Sbjct: 159 IGRLCL-DMNTLIPCTPLGVQELI 181
>UniRef50_Q0AZF5 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Syntrophomonas wolfei subsp. wolfei str.
Goettingen|Rep: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Syntrophomonas wolfei subsp. wolfei (strain Goettingen)
Length = 277
Score = 103 bits (247), Expect = 5e-21
Identities = 52/140 (37%), Positives = 83/140 (59%)
Frame = +3
Query: 369 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRD 548
I ++RQ++ +++ G P LA++ VGG+++ Y+ +K KAA G + + LP D
Sbjct: 9 IAQEIRQKLKE-KNEREGISPCLAMILVGGQKEDLHYVGLKEKAATATGGKSRLLHLPED 67
Query: 549 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 728
++ EL+AKI LN+ V GI++Q+PL + + A+ PDKDVDG + +N GR+
Sbjct: 68 TSQQELMAKIAELNQDEQVDGILLQLPLPAALEEQTDEILAAIRPDKDVDGFSLVNRGRM 127
Query: 729 XVGDLSGFIPCTPXGCVELI 788
GD GFI C C+E+I
Sbjct: 128 S-GDRPGFISCAALACLEVI 146
>UniRef50_Q6F9E6 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Proteobacteria|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Acinetobacter sp. (strain ADP1)
Length = 297
Score = 103 bits (247), Expect = 5e-21
Identities = 56/146 (38%), Positives = 86/146 (58%)
Frame = +3
Query: 351 EAVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEH 530
+A+ +S+ +++ +V R +++ G EP LA+V VG S VY+R K++ A +GI +
Sbjct: 17 KAIAQSVLEEVKLEVERYKAQ--GIEPCLAVVLVGEDPASQVYVRNKVQKAAFVGIRSLE 74
Query: 531 IRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 710
R D++E ELL +I LN VHGI+VQ+PL I+ RV + + P KDVDG ++
Sbjct: 75 FRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQ--INETRVLERIHPQKDVDGFHS 132
Query: 711 INEGRVXVGDLSGFIPCTPXGCVELI 788
N G + G PCTP GC+ L+
Sbjct: 133 ENVGGLSQG-RDVLTPCTPTGCIRLL 157
>UniRef50_Q1II76 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Acidobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Acidobacteria bacterium (strain Ellin345)
Length = 307
Score = 103 bits (246), Expect = 7e-21
Identities = 53/144 (36%), Positives = 84/144 (58%)
Frame = +3
Query: 357 VQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIR 536
+ I+ ++ +V L++K G P LA+V VG S +Y+R K+KA E GI +E
Sbjct: 11 ISAEIKTEVAAEVAELKAK--GLTPGLAVVLVGHNPASEIYVRNKVKACEMTGIYSEQHT 68
Query: 537 LPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 716
P ++ +LL + SLN + GI+VQ+PL +D+ ++ AVSP+KDVDG + +N
Sbjct: 69 PPDTVSTADLLQLVESLNRRNDIDGILVQLPLPKQ--VDSKKILLAVSPEKDVDGFHPMN 126
Query: 717 EGRVXVGDLSGFIPCTPXGCVELI 788
G + G +PCTP GC+E++
Sbjct: 127 VGYLST-VRPGLVPCTPAGCMEIL 149
>UniRef50_Q8EQ43 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=45; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Oceanobacillus iheyensis
Length = 285
Score = 102 bits (245), Expect = 9e-21
Identities = 54/144 (37%), Positives = 83/144 (57%)
Frame = +3
Query: 357 VQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIR 536
+ E ++ ++ +V L+ K G P L ++ VG S Y++ K KA GI++ I
Sbjct: 10 LSEELKQKMKIEVDELKEK--GLTPHLTVILVGDNPASKSYVKGKEKACAVTGISSNLIE 67
Query: 537 LPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 716
LP +I++ ELL I N SVHGI+VQ+PL +D ++ A+SP KDVDG + IN
Sbjct: 68 LPENISQDELLQIIDEQNNDDSVHGILVQLPLPDQ--MDEQKIIHAISPAKDVDGFHPIN 125
Query: 717 EGRVXVGDLSGFIPCTPXGCVELI 788
G++ G+ FIPCTP G + ++
Sbjct: 126 VGKMMTGE-DTFIPCTPYGILTML 148
>UniRef50_Q9A8Y0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=82; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Caulobacter crescentus (Caulobacter
vibrioides)
Length = 297
Score = 102 bits (245), Expect = 9e-21
Identities = 58/146 (39%), Positives = 80/146 (54%)
Frame = +3
Query: 351 EAVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEH 530
+A + + ++V L+++ G P LA+V VG S VY+R K + G+ +E
Sbjct: 10 KAFAADLRAKIAEEVAALKAE-HGVTPGLAVVLVGEDPASQVYVRNKGEQTTAAGMYSET 68
Query: 531 IRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 710
RLP T+ ELLA + LN P +HG++VQ P+ I V A+SPDKDVDGL
Sbjct: 69 HRLPETTTQDELLAVVAKLNADPKIHGVLVQFPVPPH--ISQMDVVAALSPDKDVDGLTV 126
Query: 711 INEGRVXVGDLSGFIPCTPXGCVELI 788
N GR+ G L PCTP GC+ LI
Sbjct: 127 TNAGRLASG-LPALAPCTPTGCMMLI 151
>UniRef50_Q6BNW9 Cluster: Debaryomyces hansenii chromosome E of
strain CBS767 of Debaryomyces hansenii; n=2;
Debaryomyces hansenii|Rep: Debaryomyces hansenii
chromosome E of strain CBS767 of Debaryomyces hansenii -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 276
Score = 101 bits (242), Expect = 2e-20
Identities = 51/123 (41%), Positives = 76/123 (61%), Gaps = 1/123 (0%)
Frame = +3
Query: 423 FEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKITSLNESPS 602
F P L I+QVGGR DS+ Y++ KLKAA+ I + ++ D++E +LL +I LN+ P
Sbjct: 74 FRPNLTIIQVGGRPDSSAYVKAKLKAAKSSNILSSLLKFDEDMSEEDLLEEIDRLNKDPK 133
Query: 603 VHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVX-VGDLSGFIPCTPXGCV 779
V+G+++Q+PL + +T+AV+ +KDVDG N G + G F PCTP G +
Sbjct: 134 VNGLLIQLPLPKH--FNETLITNAVATEKDVDGFARYNVGELTKKGGAPMFKPCTPNGIM 191
Query: 780 ELI 788
ELI
Sbjct: 192 ELI 194
>UniRef50_Q83FS2 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Tropheryma whipplei|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Tropheryma whipplei (strain Twist)
(Whipple's bacillus)
Length = 295
Score = 101 bits (242), Expect = 2e-20
Identities = 53/124 (42%), Positives = 77/124 (62%)
Frame = +3
Query: 417 SGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKITSLNES 596
+G P+LA V VG S Y+ K + + IGI + I LP + +E EL++K+ LN S
Sbjct: 29 NGVCPKLATVLVGNNPASRSYVLSKHRDCKNIGIQSTLIELPANTSEKELISKVEILNAS 88
Query: 597 PSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGFIPCTPXGC 776
V GIIVQ+PL +ID ++V +A++PDKD DGL+ +N G + G G +PCTP G
Sbjct: 89 SDVSGIIVQLPL--PESIDQNKVIEAINPDKDADGLHPLNLGYLVTGK-QGIVPCTPAGI 145
Query: 777 VELI 788
V+L+
Sbjct: 146 VKLL 149
>UniRef50_Q9ZD32 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Rickettsia|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rickettsia prowazekii
Length = 286
Score = 100 bits (240), Expect = 4e-20
Identities = 57/154 (37%), Positives = 87/154 (56%)
Frame = +3
Query: 327 MWKNSEELEAVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAE 506
M N + +A+ I DL+ ++ + K + P+LAIV VG S +Y++ K+K A
Sbjct: 1 MVNNIIDGKALANEILADLKLEIQGFKEK-TKTSPKLAIVLVGDNPASMIYVKNKIKNAH 59
Query: 507 KIGIAAEHIRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPD 686
++GI + L +I +L+ KI LN + GIIVQ+PL S +ID +++ AV P
Sbjct: 60 QVGIDTLLVNLSTNIYTDDLILKINELNLDKGISGIIVQLPLPS--SIDENKILSAVLPS 117
Query: 687 KDVDGLNTINEGRVXVGDLSGFIPCTPXGCVELI 788
KD DG + +N G + G GFIPCT GC+ +I
Sbjct: 118 KDSDGFHPLNVGYLHSGINQGFIPCTALGCLAVI 151
>UniRef50_Q3YRE3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Proteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Ehrlichia canis (strain Jake)
Length = 300
Score = 100 bits (239), Expect = 5e-20
Identities = 56/147 (38%), Positives = 83/147 (56%), Gaps = 1/147 (0%)
Frame = +3
Query: 351 EAVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEH 530
+A+ E I L + L+ ++S P L +V VG S++Y+R K + AE +G+ +E
Sbjct: 9 KAIAEDITGTLATCINDLKLQYS-LVPCLIVVLVGDDPASHLYVRNKQRKAEMLGLRSET 67
Query: 531 IRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 710
I LP +E L+ KI LN +VHGI+VQ+P+ ID + + + + P KDVDG +
Sbjct: 68 ILLPSTTSESSLIDKIHELNNDDNVHGILVQLPVPKH--IDKNLIINTIDPRKDVDGFHN 125
Query: 711 INEGRVXVGDLSG-FIPCTPXGCVELI 788
N GR+ G IPCTP GC+ LI
Sbjct: 126 DNVGRLFTGQKRNCLIPCTPRGCLYLI 152
>UniRef50_P13995 Cluster: Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor
[Includes: NAD-dependent methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)]; n=66; cellular
organisms|Rep: Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor
[Includes: NAD-dependent methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Homo sapiens (Human)
Length = 350
Score = 98.3 bits (234), Expect = 2e-19
Identities = 57/142 (40%), Positives = 85/142 (59%)
Frame = +3
Query: 363 ESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLP 542
+ I+ ++RQ+V + + P L+++ VG S+ Y+ K +AA +GI +E I P
Sbjct: 47 QQIKQEVRQEVEEWVASGNK-RPHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKP 105
Query: 543 RDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEG 722
I+E ELL I LN +V G++VQ+PL +H ID R+ +AVSPDKDVDG + IN G
Sbjct: 106 ASISEEELLNLINKLNNDDNVDGLLVQLPL-PEH-IDERRICNAVSPDKDVDGFHVINVG 163
Query: 723 RVXVGDLSGFIPCTPXGCVELI 788
R+ + D +P TP G E+I
Sbjct: 164 RMCL-DQYSMLPATPWGVWEII 184
>UniRef50_A0JTZ0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=51; Actinobacteria (class)|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Arthrobacter sp. (strain FB24)
Length = 302
Score = 98.3 bits (234), Expect = 2e-19
Identities = 52/149 (34%), Positives = 88/149 (59%), Gaps = 3/149 (2%)
Frame = +3
Query: 351 EAVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEH 530
+A +I+++L ++V +L+++ G P +A V VG S +Y+ MK K + +IG+ +
Sbjct: 11 KAAAAAIKSELAERVAKLKAR--GVTPGIATVLVGADPASQLYVSMKHKQSVEIGMNSIQ 68
Query: 531 IRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 710
LP D T+ ++ A I LN P+ HG IVQ+PL +D + + + P KD DGL+
Sbjct: 69 RELPADATQAQVEALIDELNADPACHGYIVQLPLPKH--LDTDAILERIDPAKDADGLHP 126
Query: 711 INEGRVXV---GDLSGFIPCTPXGCVELI 788
N GR+ + G+++ +PCTP G +EL+
Sbjct: 127 TNLGRLVLNVSGEITSPLPCTPRGVIELL 155
>UniRef50_A7D6I9 Cluster: Methenyltetrahydrofolate cyclohydrolase;
n=1; Halorubrum lacusprofundi ATCC 49239|Rep:
Methenyltetrahydrofolate cyclohydrolase - Halorubrum
lacusprofundi ATCC 49239
Length = 307
Score = 97.5 bits (232), Expect = 3e-19
Identities = 56/146 (38%), Positives = 79/146 (54%)
Frame = +3
Query: 351 EAVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEH 530
EAV + +D+ V L + G P LA V + S Y+ MK + E++GI + H
Sbjct: 18 EAVAADVRDDVAAHVETLEEE--GVTPGLATVLMSDDPASETYVSMKQRDCEEVGIESVH 75
Query: 531 IRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 710
+ + D EL I LNE VHGI+VQ+P+ DH +D RV ++P KDVDG +
Sbjct: 76 VEIDADAPAEELYETIDDLNEREDVHGILVQLPV-PDH-VDKRRVLRQIAPVKDVDGFHP 133
Query: 711 INEGRVXVGDLSGFIPCTPXGCVELI 788
N GR+ GD + F PCTP G +L+
Sbjct: 134 ENVGRLVAGD-ARFKPCTPHGVQKLL 158
>UniRef50_Q6ALZ5 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=27; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Desulfotalea psychrophila
Length = 296
Score = 96.7 bits (230), Expect = 6e-19
Identities = 51/145 (35%), Positives = 80/145 (55%), Gaps = 1/145 (0%)
Frame = +3
Query: 357 VQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIR 536
+++ I +++ VT ++ K+ G P L + VG S Y+ +K+K A +G
Sbjct: 11 IRKEILGEIKDAVTEMKDKY-GTVPGLVTILVGESPASMSYVSLKIKTALSLGFYEVQES 69
Query: 537 LPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 716
L + TE ELLA I N S+HG++VQ+PL I+ + A+ PDKDVD + +N
Sbjct: 70 LSVETTEAELLALIEKYNNDDSIHGVLVQLPLPKH--INEQNIITAIDPDKDVDAFHPVN 127
Query: 717 EGRVXV-GDLSGFIPCTPXGCVELI 788
GR+ + GD F+PCTP G E++
Sbjct: 128 IGRLMIGGDDVKFLPCTPAGIQEML 152
>UniRef50_UPI000038C811 Cluster: COG0190:
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl
tetrahydrofolate cyclohydrolase; n=1; Nostoc punctiforme
PCC 73102|Rep: COG0190: 5,10-methylene-tetrahydrofolate
dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase -
Nostoc punctiforme PCC 73102
Length = 292
Score = 95.9 bits (228), Expect = 1e-18
Identities = 56/146 (38%), Positives = 84/146 (57%)
Frame = +3
Query: 351 EAVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEH 530
+A+ I+ +L +T+L+ + G P LA++ VG S Y+R K KA K+GIA+
Sbjct: 12 KAIAAKIQQELSVAITQLQPE-IGRPPGLAVLMVGDNPASAAYVRNKEKACAKVGIASFG 70
Query: 531 IRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 710
P + T EL I +LN+ V GI+VQ+PL DH +DA + + PDKD DGL+
Sbjct: 71 KHFPAETTFRELEKVIAALNDDERVDGILVQLPL-PDH-LDAVALLHQIDPDKDADGLHP 128
Query: 711 INEGRVXVGDLSGFIPCTPXGCVELI 788
+N GR+ G++ G CTP G + L+
Sbjct: 129 VNLGRLVRGEI-GLRSCTPDGVMRLL 153
>UniRef50_A5CF58 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Orientia tsutsugamushi Boryong|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Orientia tsutsugamushi
(strain Boryong) (Rickettsia tsutsugamushi)
Length = 301
Score = 94.7 bits (225), Expect = 2e-18
Identities = 53/137 (38%), Positives = 79/137 (57%)
Frame = +3
Query: 378 DLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITE 557
+ + + L+ K+ +L I+ VG + S +Y+ K+ A+ IG+ +E IRL I E
Sbjct: 17 ETKNDLLALKDKYQ-ITVKLVIILVGNNDASLIYVNNKVAKAKAIGMDSEIIRLFEFIEE 75
Query: 558 IELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVXVG 737
+L + I LN +VHGIIVQ+PL IDA ++ + KDVDGLN IN G + +G
Sbjct: 76 KKLFSVIDDLNCDSTVHGIIVQLPLPPH--IDALKLFARIDSRKDVDGLNPINIGYLNIG 133
Query: 738 DLSGFIPCTPXGCVELI 788
G IPCT GC++L+
Sbjct: 134 ANQGLIPCTALGCIDLL 150
>UniRef50_Q54VK0 Cluster: Methenyl tetrahydrofolate cyclohydrolase /
NADP-dependent methylene H4F dehydrogenase; n=1;
Dictyostelium discoideum AX4|Rep: Methenyl
tetrahydrofolate cyclohydrolase / NADP-dependent
methylene H4F dehydrogenase - Dictyostelium discoideum
AX4
Length = 440
Score = 94.3 bits (224), Expect = 3e-18
Identities = 49/126 (38%), Positives = 70/126 (55%)
Frame = +3
Query: 411 KWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKITSLN 590
K SG P L ++ VG + YI+ K E +G R DI E +L+ KI +
Sbjct: 111 KNSGVTPNLVVIYVGDSKQIESYIKAKRTGCEDVGFKFTLDRFSSDIKEDQLIKKIKYHS 170
Query: 591 ESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGFIPCTPX 770
E PSVHGIIVQ+PL + DA + ++ P KDVDGL + N G++ + +IPCTP
Sbjct: 171 EDPSVHGIIVQLPLPDNLNKDA--IIQSIDPKKDVDGLTSTNLGQIMISKKPLYIPCTPL 228
Query: 771 GCVELI 788
G +E++
Sbjct: 229 GILEIL 234
>UniRef50_P56467 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Helicobacter pylori (Campylobacter pylori)
Length = 290
Score = 94.3 bits (224), Expect = 3e-18
Identities = 48/146 (32%), Positives = 87/146 (59%)
Frame = +3
Query: 351 EAVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEH 530
+A+ ++IE DL+ ++ + ++ + P+LA++ VG S Y+ MK+KA E++G+ +
Sbjct: 12 QALADNIEKDLKHKIQIITAQ-THKRPKLAVILVGKDPASITYVNMKIKACERVGMDFDL 70
Query: 531 IRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 710
L +ITE +LL+ I N ++ G++VQ+PL ID + +A+ P+KDVDG +
Sbjct: 71 KTLQENITEAKLLSLIKDYNTDQNISGVLVQLPL--PRHIDTKMILEAIDPNKDVDGFHP 128
Query: 711 INEGRVXVGDLSGFIPCTPXGCVELI 788
+N G++ F+P TP G + L+
Sbjct: 129 LNIGKLCT-QKESFLPATPMGVMRLL 153
>UniRef50_Q9HPY4 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Halobacterium salinarium (Halobacterium
halobium)
Length = 297
Score = 94.3 bits (224), Expect = 3e-18
Identities = 57/146 (39%), Positives = 79/146 (54%)
Frame = +3
Query: 351 EAVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEH 530
+AV + DL V L + +G PRLA V + ++ S Y+ MK + E++GIAAE
Sbjct: 8 DAVAAQLRADLTGAVETLET--AGVTPRLATVLMNDKQASETYVSMKQQDCEEVGIAAED 65
Query: 531 IRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 710
+R+ + + L + LN VHGI+VQ P DH D RV AV P KDVDG +
Sbjct: 66 VRIDPEASADTLFDTVAELNAREDVHGILVQDP-TPDHVPD-ERVLSAVDPAKDVDGFHP 123
Query: 711 INEGRVXVGDLSGFIPCTPXGCVELI 788
N G++ VG F PCTP G +L+
Sbjct: 124 ENVGKL-VGGTPRFKPCTPHGVQKLL 148
>UniRef50_Q189R8 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=11; Clostridiales|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Clostridium difficile (strain 630)
Length = 290
Score = 93.9 bits (223), Expect = 4e-18
Identities = 52/144 (36%), Positives = 79/144 (54%)
Frame = +3
Query: 357 VQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIR 536
V + I +L ++V L + G P+L IV+VG R D Y R LK + IGI E +
Sbjct: 16 VADKISEELIKEVDLLVKE--GINPKLTIVRVGARSDDLSYERGALKRCQNIGITTEVLE 73
Query: 537 LPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 716
L DIT+ E + + +N+ +V+GI+ PL ++ + ++P+KDVD + IN
Sbjct: 74 LAEDITQEEYIDVLKRVNDDKNVNGILCFRPLPKH--LNEEVIKYVIAPEKDVDCFSPIN 131
Query: 717 EGRVXVGDLSGFIPCTPXGCVELI 788
+V GD SGF PCTP VE++
Sbjct: 132 SAKVMEGDKSGFPPCTPTAVVEIL 155
>UniRef50_Q86F84 Cluster: Clone ZZD1003 mRNA sequence; n=1;
Schistosoma japonicum|Rep: Clone ZZD1003 mRNA sequence -
Schistosoma japonicum (Blood fluke)
Length = 332
Score = 93.5 bits (222), Expect = 5e-18
Identities = 48/126 (38%), Positives = 75/126 (59%)
Frame = +3
Query: 357 VQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIR 536
V +++ + ++ V L+S + + P+L +++VG S +YI+ K K A+K GI H+R
Sbjct: 12 VAQAVGHKIKLDVALLKSSFDVY-PKLVVIEVGELPQSKLYIKQKFKFAKKYGILLSHMR 70
Query: 537 LPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 716
LP I+E LL + LN SVHGI +Q+P DSD I+ +AV+ KDV+GLN+ N
Sbjct: 71 LPSHISESLLLDYVYKLNADSSVHGITLQLPFDSDTNINVTNSLNAVATHKDVEGLNSYN 130
Query: 717 EGRVXV 734
+ V
Sbjct: 131 TALLSV 136
>UniRef50_Q6F1V0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Mollicutes|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mesoplasma florum (Acholeplasma florum)
Length = 286
Score = 92.7 bits (220), Expect = 1e-17
Identities = 45/121 (37%), Positives = 72/121 (59%)
Frame = +3
Query: 426 EPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKITSLNESPSV 605
+P+L ++ VG S VY+ K+K A ++GI +E +R +DI + EL KI LN ++
Sbjct: 31 KPKLVVIMVGNDPASEVYVSHKIKVANEVGIYSELLRFDKDIKKEELYNKINELNNDQNI 90
Query: 606 HGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGFIPCTPXGCVEL 785
GI++Q+PL D + + A++P KDVDG + IN+G++ G PCTP G + L
Sbjct: 91 DGILLQLPLPIDFIEEDY--LQAITPSKDVDGFHYINQGKMLQG-YDTVYPCTPLGIINL 147
Query: 786 I 788
+
Sbjct: 148 L 148
>UniRef50_A4EAK0 Cluster: Putative uncharacterized protein; n=3;
Bacteria|Rep: Putative uncharacterized protein -
Collinsella aerofaciens ATCC 25986
Length = 284
Score = 91.9 bits (218), Expect = 2e-17
Identities = 54/144 (37%), Positives = 76/144 (52%)
Frame = +3
Query: 357 VQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIR 536
V ++ +L + LR + G P LAIV+VG RED Y R LK EK+GI A +
Sbjct: 10 VARALTEELAARCAALREQ--GVVPMLAIVRVGEREDDLSYERGALKRCEKVGIEARRVL 67
Query: 537 LPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 716
LP D+++ ELLA I +N P+VHG ++ PL + +D V A+ P KDVD + +
Sbjct: 68 LPVDVSQDELLAAIKDINADPAVHGCLMFRPLPA--GLDEDAVAAALDPAKDVDSMTPAS 125
Query: 717 EGRVXVGDLSGFIPCTPXGCVELI 788
G GF PCT + L+
Sbjct: 126 LLTTLSGRGEGFAPCTAEAVLALL 149
>UniRef50_O83714 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Treponema pallidum
Length = 315
Score = 91.9 bits (218), Expect = 2e-17
Identities = 54/136 (39%), Positives = 76/136 (55%)
Frame = +3
Query: 381 LRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEI 560
L +V LR+ G P LA V VG S Y+ K +A + + E RLP +
Sbjct: 19 LATRVQALRAA-VGTAPFLAAVLVGDDPASCTYVAAKQRALARAHLRGETHRLPAHASHA 77
Query: 561 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 740
++L I LNE VHGI++Q+PL + +DA RV AV+P+KDVDG + +N G + +
Sbjct: 78 QVLELIARLNEDARVHGILIQLPLPAH--LDAARVCRAVAPEKDVDGFHPLNCGALFLAQ 135
Query: 741 LSGFIPCTPXGCVELI 788
GF+PCTP G V L+
Sbjct: 136 -PGFVPCTPAGIVHLL 150
>UniRef50_Q4RT28 Cluster: Chromosome 12 SCAF14999, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 12 SCAF14999, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 342
Score = 90.6 bits (215), Expect = 4e-17
Identities = 57/164 (34%), Positives = 89/164 (54%), Gaps = 3/164 (1%)
Frame = +3
Query: 306 KILRIRIMWKNSEELEAVQESIENDLRQQVTRLRSKW--SGFE-PRLAIVQVGGREDSNV 476
++ ++ + E + + +R++ KW +G P L++V VG S+
Sbjct: 17 QVCKLHMSASRQEAVVISGRKLARQIREEARADVEKWVLTGHRRPHLSVVLVGDDPASHS 76
Query: 477 YIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDA 656
Y+ K +AA IGI++E I DI+E ELL I LN V G++VQ+PL +H ID
Sbjct: 77 YVLNKTRAAADIGISSETILKHSDISEEELLDLIDKLNTDHRVDGLLVQLPL-PEH-IDE 134
Query: 657 HRVTDAVSPDKDVDGLNTINEGRVXVGDLSGFIPCTPXGCVELI 788
+ +AV+P KDVDG + +N GR+ + D S +P TP G E+I
Sbjct: 135 RTICNAVAPTKDVDGFHVVNVGRMCL-DQSSMLPATPWGVWEII 177
>UniRef50_Q8RAD0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Thermoanaerobacter|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermoanaerobacter tengcongensis
Length = 280
Score = 90.6 bits (215), Expect = 4e-17
Identities = 49/142 (34%), Positives = 79/142 (55%)
Frame = +3
Query: 363 ESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLP 542
+ I N ++++V R ++ G++PRLAI+ G E S VY K+KA E +GI A+ +
Sbjct: 9 KEISNRIKEEVKREIQEF-GYKPRLAILMAGDDESSKVYANSKVKACESVGIEAK-VYYF 66
Query: 543 RDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEG 722
+ E + + LNE HGI+++MPL D +V D ++P KDVD ++ N G
Sbjct: 67 SEKEEDKFFDTLEKLNEDKDTHGIMIEMPLPK--GFDVDKVYDTINPYKDVDCISNYNMG 124
Query: 723 RVXVGDLSGFIPCTPXGCVELI 788
R+ G F+PCTP + ++
Sbjct: 125 RLFAGK-PLFVPCTPKAIIHIL 145
>UniRef50_Q4FTX6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=24; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Psychrobacter arcticum
Length = 295
Score = 90.6 bits (215), Expect = 4e-17
Identities = 50/146 (34%), Positives = 82/146 (56%)
Frame = +3
Query: 351 EAVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEH 530
+A+ + IE L +V +++K +G P LA + VG S Y+RMK A +++G+ +
Sbjct: 20 KALAKQIEQQLSTRVDAIKAK-TGRTPSLATILVGDDPASATYVRMKGNACQRVGMDSIR 78
Query: 531 IRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 710
+ +P T EL+AKI LN +P VHGI++Q P+ + ID + + KDVDG+
Sbjct: 79 VEMPSATTTAELMAKIDELNNNPDVHGILLQHPVPAH--IDERACFEQIDLAKDVDGVTC 136
Query: 711 INEGRVXVGDLSGFIPCTPXGCVELI 788
+ GR+ + S + CTP G + L+
Sbjct: 137 LGFGRMAM-QQSAYGSCTPQGIMHLL 161
>UniRef50_A7DNA7 Cluster: Methylenetetrahydrofolate dehydrogenase
(NADP(+)); n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Methylenetetrahydrofolate dehydrogenase
(NADP(+)) - Candidatus Nitrosopumilus maritimus SCM1
Length = 287
Score = 90.2 bits (214), Expect = 5e-17
Identities = 50/145 (34%), Positives = 81/145 (55%)
Frame = +3
Query: 351 EAVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEH 530
+ + +S+++ +++ V L+++ G P LA V VG S Y+R K +A E++GI +
Sbjct: 9 KVISQSVKDRVKKAVEELKNQ--GINPCLATVLVGDNPASATYVRNKHRACEEVGITTKD 66
Query: 531 IRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 710
+L T+ +L I +LN SVHGI+VQ+PL +D T +SP KDVDGL
Sbjct: 67 HKLDASTTQAQLNEIIENLNNDNSVHGILVQLPLPEQ--LDEFTTTSRISPLKDVDGLTP 124
Query: 711 INEGRVXVGDLSGFIPCTPXGCVEL 785
N G + + + + CTP G +E+
Sbjct: 125 HNAGLLAM-KKAALVACTPSGVMEM 148
>UniRef50_UPI00015B49ED Cluster: PREDICTED: similar to putative
glyoxylate reductase/hydroxypyruvate reductase; n=1;
Nasonia vitripennis|Rep: PREDICTED: similar to putative
glyoxylate reductase/hydroxypyruvate reductase - Nasonia
vitripennis
Length = 699
Score = 89.8 bits (213), Expect = 7e-17
Identities = 48/120 (40%), Positives = 71/120 (59%)
Frame = +3
Query: 429 PRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKITSLNESPSVH 608
P+L + VG S Y+ K+KAA+ +GI +E +R IT+ ELL ++ LN+ P+V
Sbjct: 59 PKLIAILVGNNPASKAYVGRKVKAAKTVGIESETLRFEDSITQEELLHEVQKLNDDPTVD 118
Query: 609 GIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGFIPCTPXGCVELI 788
G++VQ+P+ +H I V AV+P KDVDG + N G + + + G IP T G ELI
Sbjct: 119 GLLVQLPV-PEH-ISEREVCQAVTPTKDVDGFHLSNIGNLALNN-KGIIPATALGVKELI 175
>UniRef50_Q5SJ94 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermus thermophilus|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermus thermophilus (strain HB8 / ATCC
27634 / DSM 579)
Length = 282
Score = 89.4 bits (212), Expect = 9e-17
Identities = 50/130 (38%), Positives = 71/130 (54%)
Frame = +3
Query: 399 RLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKI 578
R R + F P L ++++G S Y+R+K K A +G ++ P D+ E LL +I
Sbjct: 20 RARLRSLSFTPSLRVIRLGEDPASVAYVRLKDKRARALGYRSQVEVYPEDLPEEALLERI 79
Query: 579 TSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGFIP 758
+LN V GI+VQ+PL I RV +A+ P KDVDG + +N GR+ G G P
Sbjct: 80 AALNADEEVDGILVQLPLPPH--IRTQRVLEAIHPLKDVDGFHPLNVGRLWSGG-KGLFP 136
Query: 759 CTPXGCVELI 788
CTP G V L+
Sbjct: 137 CTPLGVVRLL 146
>UniRef50_Q2B9L0 Cluster: Bifunctional protein FolD; n=1; Bacillus
sp. NRRL B-14911|Rep: Bifunctional protein FolD -
Bacillus sp. NRRL B-14911
Length = 322
Score = 89.0 bits (211), Expect = 1e-16
Identities = 50/144 (34%), Positives = 76/144 (52%)
Frame = +3
Query: 357 VQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIR 536
V ++ L +V L K G P LA + VG S Y+RMK A ++GI +E I
Sbjct: 51 VAADVKEGLMPRVENLTQK--GITPCLATILVGDDPSSETYVRMKGNACARLGIRSERIH 108
Query: 537 LPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 716
+P++ T EL+ I LNE+ VHGI++Q P+ ID + + +S DKDVDG+ +
Sbjct: 109 MPKETTTEELVKTIEELNENKEVHGILLQHPVPGH--IDERKAFETISIDKDVDGVTSHG 166
Query: 717 EGRVXVGDLSGFIPCTPXGCVELI 788
G+ +G + CTP + +I
Sbjct: 167 YGQTALG-FGTYPSCTPAAIMAII 189
>UniRef50_Q3AYX2 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=36; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Synechococcus sp. (strain CC9902)
Length = 293
Score = 89.0 bits (211), Expect = 1e-16
Identities = 51/146 (34%), Positives = 84/146 (57%)
Frame = +3
Query: 351 EAVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEH 530
+A+ +++E+ L+ Q+ + +G P LA+++VG S VY+ K KA +IG+A+
Sbjct: 8 KALAKAVESRLQAQIESNLPQ-AGRPPGLAVLRVGDDPASAVYVANKEKACARIGVASYG 66
Query: 531 IRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 710
LP E+L+ I LN P V GI++Q+PL +D + A+ P+KD DGL+T
Sbjct: 67 AHLPSSTPFAEVLSTIQQLNADPRVDGILLQLPL--PEGLDEGPLLMAIDPEKDADGLHT 124
Query: 711 INEGRVXVGDLSGFIPCTPXGCVELI 788
+N GR+ G+ G CTP G + ++
Sbjct: 125 LNLGRLLKGE-QGPRSCTPAGVMAML 149
>UniRef50_A3PVV6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; Actinobacteridae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycobacterium sp. (strain JLS)
Length = 288
Score = 87.4 bits (207), Expect = 4e-16
Identities = 53/146 (36%), Positives = 78/146 (53%)
Frame = +3
Query: 351 EAVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEH 530
+A ++ I DL+++V L + G P L V VG S Y+R K K+GI +
Sbjct: 12 KATRDEIFVDLKERVAALTEQ--GRTPGLGTVLVGDDPGSQAYVRGKHSDCAKVGINSIR 69
Query: 531 IRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 710
LP DI++ EL A I LN +P G IVQ+PL +D + + + P KD DGL+
Sbjct: 70 RDLPADISQAELDATIDELNANPECTGYIVQLPLPKH--LDENAALERIDPGKDADGLHP 127
Query: 711 INEGRVXVGDLSGFIPCTPXGCVELI 788
N GR+ + + + +PCTP G V L+
Sbjct: 128 TNLGRLVLNEPAP-LPCTPRGIVHLL 152
>UniRef50_Q3A1Q7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Pelobacter carbinolicus (strain DSM 2380 / Gra Bd 1)
Length = 290
Score = 86.6 bits (205), Expect = 6e-16
Identities = 47/143 (32%), Positives = 77/143 (53%)
Frame = +3
Query: 345 ELEAVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAA 524
E + V ++ D+ ++V L+ K G P L + VG S Y+ K + +++GIA+
Sbjct: 7 EGKVVAAAVLEDVARRVAVLKDK--GISPGLGTILVGDDGPSVSYVNKKRETCKQVGIAS 64
Query: 525 EHIRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGL 704
H +P T+ +LLA + N+SP V I+Q PL D + + + P+KD DGL
Sbjct: 65 FHNEIPASATQSDLLAAVRDFNDSPDVDAYIIQYPLPK--GFDFNEALNLMLPEKDADGL 122
Query: 705 NTINEGRVXVGDLSGFIPCTPXG 773
+ +N GR+ + + G +PCTP G
Sbjct: 123 HPVNLGRLVLQE-PGPVPCTPAG 144
>UniRef50_A1HML1 Cluster: Methenyltetrahydrofolate cyclohydrolase;
n=1; Thermosinus carboxydivorans Nor1|Rep:
Methenyltetrahydrofolate cyclohydrolase - Thermosinus
carboxydivorans Nor1
Length = 279
Score = 86.2 bits (204), Expect = 8e-16
Identities = 49/118 (41%), Positives = 66/118 (55%)
Frame = +3
Query: 435 LAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKITSLNESPSVHGI 614
LAI+ VG S +Y +K A +G+ A LP D TE E+LA + LNE +HGI
Sbjct: 34 LAILLVGNDAASRIYADRLVKLATGLGVQAVVRHLPADATEEEVLALVCELNEDDHIHGI 93
Query: 615 IVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGFIPCTPXGCVELI 788
+ MPL A D RV A++PDKDVD L+ +N G V G S + PCTP + ++
Sbjct: 94 LPMMPLPPHLATD--RVAAALAPDKDVDALHPLNAGLVATGK-SRWAPCTPRAVMAIL 148
>UniRef50_Q74GN1 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Bacteria|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Geobacter sulfurreducens
Length = 290
Score = 86.2 bits (204), Expect = 8e-16
Identities = 44/120 (36%), Positives = 67/120 (55%)
Frame = +3
Query: 429 PRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKITSLNESPSVH 608
P + I+ VG S Y++ K+ + G + +R P I E ELLAKI +NE P+
Sbjct: 32 PHMTIILVGEHAPSESYVKSKIATSGLAGFESTLLRFPETIRESELLAKIKEVNEDPTTD 91
Query: 609 GIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGFIPCTPXGCVELI 788
G+IVQ+PL I+ V +A++P+KD+DG + N GR+ +G F P T G +L+
Sbjct: 92 GLIVQLPLPKH--INQQHVINAIAPEKDIDGFHPANFGRMTLGQ-KAFRPATAYGICKLL 148
>UniRef50_Q6D2E6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Erwinia carotovora subsp. atroseptica (Pectobacterium
atrosepticum)
Length = 287
Score = 85.8 bits (203), Expect = 1e-15
Identities = 49/146 (33%), Positives = 79/146 (54%)
Frame = +3
Query: 351 EAVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEH 530
+ + + +++++ +VT+ ++ P LA+V VG S +Y+ K K E++G +
Sbjct: 9 KTIAQQVKDEVAARVTQRLAEGKR-APGLAVVLVGDNPASQIYVTSKRKVCEEVGFISRS 67
Query: 531 IRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 710
LP TE ELLA I LN ++ GI+VQ+PL ID +V + ++PDKDVDG +
Sbjct: 68 YDLPITTTESELLALIDQLNADQAIDGILVQLPL--PEGIDNTKVIERIAPDKDVDGFHP 125
Query: 711 INEGRVXVGDLSGFIPCTPXGCVELI 788
N GR+ CTP G + L+
Sbjct: 126 YNVGRL-CQRAPLLRACTPRGIITLL 150
>UniRef50_UPI000065DF90 Cluster: methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 2-like; n=1; Takifugu
rubripes|Rep: methylenetetrahydrofolate dehydrogenase
(NADP+ dependent) 2-like - Takifugu rubripes
Length = 400
Score = 85.0 bits (201), Expect = 2e-15
Identities = 48/158 (30%), Positives = 85/158 (53%)
Frame = +3
Query: 315 RIRIMWKNSEELEAVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKL 494
R ++ +E +Q I+ D+ + V + P L +V VG S Y++ K
Sbjct: 5 RAAVVISGTELARQIQREIQRDVEELVAQ-----GNMRPHLGVVLVGEDPASRTYVKNKT 59
Query: 495 KAAEKIGIAAEHIRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDA 674
+AA +GI+++ + P +++ ELL I +N V G++VQ+PL +H I+ V +A
Sbjct: 60 RAASILGISSDTVVRPSSVSQEELLELIDKMNRDWRVSGLLVQLPL-PEH-INERAVCNA 117
Query: 675 VSPDKDVDGLNTINEGRVXVGDLSGFIPCTPXGCVELI 788
++P+KDVDG + +N G++ + D +P TP E+I
Sbjct: 118 IAPEKDVDGFHIVNIGKLCL-DQRSMVPATPAAVWEII 154
>UniRef50_Q5FJG5 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Firmicutes|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Lactobacillus acidophilus
Length = 283
Score = 84.6 bits (200), Expect = 3e-15
Identities = 47/137 (34%), Positives = 77/137 (56%), Gaps = 1/137 (0%)
Frame = +3
Query: 381 LRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEI 560
L+++V L+ + G P ++ +G S +Y+R K + AEK+GI + +LP D +
Sbjct: 18 LKEKVKDLKEE--GITPHFCVINIGDDPASKIYVRTKKRRAEKMGIIQDIYQLPADTKQE 75
Query: 561 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 740
L I LNE P ++G++VQ+P + IDA + + + P+KDVDGL N GR+ +
Sbjct: 76 VALNLIDKLNEDPDINGVMVQLP--APEQIDADELLERIDPNKDVDGLTPSNIGRIWME- 132
Query: 741 LSGFI-PCTPXGCVELI 788
+ FI P T G + L+
Sbjct: 133 -NHFIEPATAEGIIALL 148
>UniRef50_Q74J95 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Lactobacillus|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Lactobacillus johnsonii
Length = 283
Score = 84.6 bits (200), Expect = 3e-15
Identities = 41/145 (28%), Positives = 84/145 (57%), Gaps = 1/145 (0%)
Frame = +3
Query: 357 VQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIR 536
+ + + + + +V +L+ + G P + ++ VG S +Y R K K AEK+G+ + +
Sbjct: 10 IAKQLNQETKTRVDKLKEE--GIIPGIVVILVGDDPASVIYTRNKQKNAEKLGMKSILRK 67
Query: 537 LPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 716
P+D+++ E+L I N+ P++H I++Q+PL ++ + +A++P+KDVDG N+ N
Sbjct: 68 FPKDVSQAEVLQAIHHYNDDPTIHAILIQLPLPKH--LNQTELIEAIAPEKDVDGFNSKN 125
Query: 717 EGRVXVGDLSGF-IPCTPXGCVELI 788
G++ + + + CT G + L+
Sbjct: 126 VGKLYNNEEGHYPVSCTSRGIMTLL 150
>UniRef50_Q97HC9 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; Clostridium|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Clostridium acetobutylicum
Length = 278
Score = 83.8 bits (198), Expect = 4e-15
Identities = 47/120 (39%), Positives = 66/120 (55%)
Frame = +3
Query: 429 PRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKITSLNESPSVH 608
P +A + VG S Y+ + K +E +GI + I L I E EL+ I LN +H
Sbjct: 33 PCIASITVGDDGGSLYYVNNQKKVSESLGIEFKSIFLDESIREEELIKLIEGLNVDNKIH 92
Query: 609 GIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGFIPCTPXGCVELI 788
GI++Q+PL + IDA VT + +KD+D L IN G+ G+ S FIPCTP + LI
Sbjct: 93 GIMLQLPLPNH--IDAKLVTSKIDANKDIDSLTDINTGKFYKGEKS-FIPCTPRSIINLI 149
>UniRef50_Q0AWX5 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Syntrophomonas wolfei subsp. wolfei str.
Goettingen|Rep: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Syntrophomonas wolfei subsp. wolfei (strain Goettingen)
Length = 272
Score = 83.8 bits (198), Expect = 4e-15
Identities = 47/138 (34%), Positives = 78/138 (56%), Gaps = 1/138 (0%)
Frame = +3
Query: 378 DLRQQVT-RLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDIT 554
D+R+Q+ R+R + LAI++VG S Y+R K AE+ G+ E + LP +
Sbjct: 7 DIREQIKERVRQSAEEVKMGLAIIRVGDDPSSMAYVRGIRKFAEETGVKVEIVNLPDAVG 66
Query: 555 EIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVXV 734
E ELL I LN S + GI++Q PL + +++A + +A+ DKDV+G++ N G++ +
Sbjct: 67 ERELLKTIGDLNNSSEITGIMLQTPLPA--SLNASHLVNAIDFDKDVEGIHNYNLGKL-I 123
Query: 735 GDLSGFIPCTPXGCVELI 788
G PCTP + ++
Sbjct: 124 SKEEGVRPCTPKAVISML 141
>UniRef50_Q9KQQ6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=44; Gammaproteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Vibrio cholerae
Length = 286
Score = 83.4 bits (197), Expect = 6e-15
Identities = 43/120 (35%), Positives = 68/120 (56%)
Frame = +3
Query: 429 PRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKITSLNESPSVH 608
P LA+V VG S VY+ K +A E++G ++ LP +E LL+ + LN P +
Sbjct: 34 PGLAVVLVGEDPASQVYVGSKRRACEEVGFVSKSFDLPATASEEALLSLVEELNNDPQID 93
Query: 609 GIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGFIPCTPXGCVELI 788
GI+VQ+PL + +D +V +++ P+KDVDG + N GR+ + CTP G + L+
Sbjct: 94 GILVQLPLPA--GMDTTKVLESIHPEKDVDGFHPYNVGRL-AQRIPKLRSCTPKGIITLL 150
>UniRef50_Q4S6Y9 Cluster: Chromosome 14 SCAF14723, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 14 SCAF14723, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 1066
Score = 82.6 bits (195), Expect = 1e-14
Identities = 47/134 (35%), Positives = 76/134 (56%), Gaps = 1/134 (0%)
Frame = +3
Query: 384 RQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIE 563
++ +T L+ + P LAI+Q G ED + + + K A +IG+ I L ++ +EIE
Sbjct: 8 KEMITVLQRRNPAIRPSLAIIQAG--EDDGL-LEINKKMARRIGLNVTQICLAKECSEIE 64
Query: 564 LLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVXVGDL 743
++ ++ L+E P VHG+ + +P A RV A+ P+KDVDGL+ +N G + GDL
Sbjct: 65 IVTEVLKLSEDPGVHGLYLHLP----QASLTSRVLTALKPEKDVDGLSDLNTGCLIRGDL 120
Query: 744 S-GFIPCTPXGCVE 782
S GF+P +E
Sbjct: 121 SAGFVPPVTSAVLE 134
>UniRef50_Q14NV1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Spiroplasma citri|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Spiroplasma citri
Length = 286
Score = 81.8 bits (193), Expect = 2e-14
Identities = 46/144 (31%), Positives = 78/144 (54%)
Frame = +3
Query: 357 VQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIR 536
V E I+ + +Q+ ++++K P L I+Q+G + S YI+ K A EK+G+ + +
Sbjct: 12 VSELIKAKITEQILKIKAKKQRV-PALTIIQIGNNKASTTYIKNKKIACEKVGVTCKVLN 70
Query: 537 LPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 716
P ITE L+ I LN + + I+VQ+PL S I++ +V + + KDVDG
Sbjct: 71 YPDIITESALIKIINDLNNNSKIDAILVQLPLPSH--INSEKVINTIITKKDVDGFTPKI 128
Query: 717 EGRVXVGDLSGFIPCTPXGCVELI 788
G + +G + +P TP G + L+
Sbjct: 129 LGNLMLGHYN-LLPSTPKGIIALL 151
>UniRef50_A5V1H2 Cluster: Methylenetetrahydrofolate dehydrogenase
(NADP(+)); n=5; Chloroflexi (class)|Rep:
Methylenetetrahydrofolate dehydrogenase (NADP(+)) -
Roseiflexus sp. RS-1
Length = 288
Score = 80.2 bits (189), Expect = 5e-14
Identities = 48/145 (33%), Positives = 80/145 (55%)
Frame = +3
Query: 354 AVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHI 533
A+ +++ +LR T+ + +G P LA+V++ G S+ Y R K E+IGI
Sbjct: 10 ALAKTLREELRAD-TQAFIQNNGIAPSLAVVKIAGDPASDRYTRTIRKGCEEIGITFTDH 68
Query: 534 RLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTI 713
LP + T+ L I++L+ ++HGI++ +PL +D+ R + P KDVDG++
Sbjct: 69 TLPPETTQAMLEETISALSFDRTIHGILLHLPLPP--GLDSARAIAQIDPAKDVDGVHPY 126
Query: 714 NEGRVXVGDLSGFIPCTPXGCVELI 788
N G + +G G IP TP G +EL+
Sbjct: 127 NAGLLAMG-RPGLIPNTPAGGMELL 150
>UniRef50_O65269 Cluster: F6N23.28 protein; n=1; Arabidopsis
thaliana|Rep: F6N23.28 protein - Arabidopsis thaliana
(Mouse-ear cress)
Length = 310
Score = 79.0 bits (186), Expect = 1e-13
Identities = 37/82 (45%), Positives = 56/82 (68%), Gaps = 1/82 (1%)
Frame = +3
Query: 546 DITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGR 725
D +E E+L ++ N+ PSVHG++VQ+PL S +D + +AVS +KDVDG + +N GR
Sbjct: 89 DSSEEEVLKYVSGFNDDPSVHGVLVQLPLPSH--MDEQNILNAVSIEKDVDGFHPLNIGR 146
Query: 726 VXV-GDLSGFIPCTPXGCVELI 788
+ + G F+PCTP GC+EL+
Sbjct: 147 LAMRGREPLFVPCTPKGCIELL 168
>UniRef50_O51057 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Borrelia burgdorferi group|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Borrelia burgdorferi
(Lyme disease spirochete)
Length = 308
Score = 78.6 bits (185), Expect = 2e-13
Identities = 39/118 (33%), Positives = 70/118 (59%)
Frame = +3
Query: 435 LAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKITSLNESPSVHGI 614
L +V SN+Y+ +K + A++IG+ E I+ + + ++L I N++ S GI
Sbjct: 40 LKVVLANDEPASNLYVSIKSRVAKEIGLNVEVIKFSANSVQSDILEVIDRENKNLSTDGI 99
Query: 615 IVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGFIPCTPXGCVELI 788
IVQ+PL +D + + +++ KDVDGL+ +N G++ +GD GFIPCT ++++
Sbjct: 100 IVQLPLLK--GMDLNSILNSIVYSKDVDGLSFVNLGKMILGDKKGFIPCTALAVLKIL 155
>UniRef50_UPI00006CCCC6 Cluster: methylenetetrahydrofolate
dehydrogenase; n=1; Tetrahymena thermophila SB210|Rep:
methylenetetrahydrofolate dehydrogenase - Tetrahymena
thermophila SB210
Length = 342
Score = 78.2 bits (184), Expect = 2e-13
Identities = 43/121 (35%), Positives = 66/121 (54%)
Frame = +3
Query: 426 EPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKITSLNESPSV 605
+P L I+ VG S YI+ KL+A E IGI E DI E ++L+ I +LN +
Sbjct: 48 KPGLGIILVGNNPASLSYIKKKLQACEAIGIRHELYHFSEDIQEYDVLSAIDNLNRKDDI 107
Query: 606 HGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGFIPCTPXGCVEL 785
I+ Q+PL S ID + V + +S +KD DGL +N + + +PCTP C+++
Sbjct: 108 DAIMAQLPLPSH--IDKNNVINMISSEKDADGLK-LNSNN--LDPKANILPCTPAACLKI 162
Query: 786 I 788
+
Sbjct: 163 L 163
>UniRef50_UPI00006CB712 Cluster: tetrahydrofolate
dehydrogenase/cyclohydrolase, NAD(P)-binding domain;
n=1; Tetrahymena thermophila SB210|Rep: tetrahydrofolate
dehydrogenase/cyclohydrolase, NAD(P)-binding domain -
Tetrahymena thermophila SB210
Length = 377
Score = 77.8 bits (183), Expect = 3e-13
Identities = 43/142 (30%), Positives = 75/142 (52%), Gaps = 2/142 (1%)
Frame = +3
Query: 369 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRD 548
I D+ Q+V + + EP+LAI+ VG DS Y+ +K +A +++G+ +E I LP
Sbjct: 36 ISKDVLQKVKERILRVNIREPKLAIILVGNAADSISYVSVKQRACKRVGVQSELIHLPET 95
Query: 549 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT--INEG 722
T+ E++ + LN+ V I+ Q+P + I V + + P KDVDGL + +
Sbjct: 96 TTQKEVIQIVEDLNKREDVDSILTQLPFPAQ--ISKTIVINQIEPSKDVDGLQRCFLTQQ 153
Query: 723 RVXVGDLSGFIPCTPXGCVELI 788
+ + +PCTP C+ ++
Sbjct: 154 LIWDDHNNRALPCTPQSCLHIL 175
>UniRef50_Q0SFQ8 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Actinomycetales|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rhodococcus sp. (strain RHA1)
Length = 297
Score = 77.8 bits (183), Expect = 3e-13
Identities = 48/141 (34%), Positives = 71/141 (50%)
Frame = +3
Query: 366 SIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPR 545
SI ND L G P+LA+VQ E + Y+R AA++ GI + + L
Sbjct: 13 SIRNDASVAAAALNDL--GTRPKLAVVQATDDESTAWYVRSIASAAKRTGILCDIVDLGA 70
Query: 546 DITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGR 725
+ ++ + + L P VHGII+Q PL +DA R +A++P KDVDG N ++ GR
Sbjct: 71 AASTEQIRSTLVELGHDPDVHGIILQTPLPDGTDLDALR--EAINPAKDVDGANPVSLGR 128
Query: 726 VXVGDLSGFIPCTPXGCVELI 788
+ V L F P T + L+
Sbjct: 129 L-VARLPAFAPATAQAVIALL 148
>UniRef50_Q987T6 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Alphaproteobacteria|Rep: Bifunctional protein folD
2 [Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rhizobium loti (Mesorhizobium loti)
Length = 306
Score = 77.0 bits (181), Expect = 5e-13
Identities = 47/127 (37%), Positives = 65/127 (51%)
Frame = +3
Query: 408 SKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKITSL 587
+K GF P+L + VG + +VY+R + A+ GI E R P IT EL A I L
Sbjct: 30 AKAEGFPPKLISITVGDTDAVDVYVRNQRAKAQLAGIDFEERRFPATITSGELEAAIHGL 89
Query: 588 NESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGFIPCTP 767
N P V GII+Q P+ + I + AV P KDV+G++ + G + L PCT
Sbjct: 90 NADPRVTGIIIQRPVPAH--ISVKTLQAAVHPLKDVEGMHPASIGNIVYNQLD-LAPCTA 146
Query: 768 XGCVELI 788
VEL+
Sbjct: 147 AASVELL 153
>UniRef50_UPI0000DB7ABF Cluster: PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor; n=1; Apis mellifera|Rep:
PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor - Apis mellifera
Length = 407
Score = 75.8 bits (178), Expect = 1e-12
Identities = 46/144 (31%), Positives = 77/144 (53%)
Frame = +3
Query: 357 VQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIR 536
+ I+N+L+ V + + P+L ++VG S +Y+ K+KAA IGI I
Sbjct: 118 IANKIQNELKITVDNWIND-NKKRPKLVAIKVGNNPASKIYVEKKIKAANFIGIENYTIH 176
Query: 537 LPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 716
L ++ +++ +I +LN+ +V GI+VQ+PL ++ V A+ P KDVDG + N
Sbjct: 177 LDEKSSQQDIINEIDNLNKDKTVDGILVQLPLIKH--MNEQEVCQAIIPSKDVDGFHLEN 234
Query: 717 EGRVXVGDLSGFIPCTPXGCVELI 788
G + + + +G IP T ELI
Sbjct: 235 LGNLAL-NRNGIIPATALAVKELI 257
>UniRef50_Q6MI74 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Bdellovibrio bacteriovorus|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Bdellovibrio
bacteriovorus
Length = 288
Score = 75.8 bits (178), Expect = 1e-12
Identities = 48/144 (33%), Positives = 75/144 (52%)
Frame = +3
Query: 357 VQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIR 536
V + + L +V + + + G P+L++V VG + S+VY++ K A EKIG+ +
Sbjct: 10 VAKEVRASLVPRVAKFKETY-GRAPQLSVVIVGDDKASHVYVKNKKIACEKIGMTSTIHT 68
Query: 537 LPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 716
LP + T+ EL ++ LN V GI+VQ PL + + V VS +KD DGL +
Sbjct: 69 LPAETTQSELNQILSKLNNDNGVDGILVQFPLPKH--LSSDEVLKLVSAEKDADGLTYES 126
Query: 717 EGRVXVGDLSGFIPCTPXGCVELI 788
G G PCTP G +E++
Sbjct: 127 LGYFFAGK-PLVSPCTPAGVMEIL 149
>UniRef50_Q5RGD2 Cluster: Novel protein similar to vertebrate
formyltetrahydrofolate synthetase domain containing 1;
n=1; Danio rerio|Rep: Novel protein similar to
vertebrate formyltetrahydrofolate synthetase domain
containing 1 - Danio rerio (Zebrafish) (Brachydanio
rerio)
Length = 217
Score = 75.4 bits (177), Expect = 2e-12
Identities = 47/136 (34%), Positives = 71/136 (52%), Gaps = 1/136 (0%)
Frame = +3
Query: 384 RQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIE 563
R+++ + G +P LAI+Q G ED + + M K A KIG+ I LP TE E
Sbjct: 7 REELKSIGENNPGLKPTLAIIQAG--EDDGL-LEMNKKMAGKIGLNVMQICLPHRCTEEE 63
Query: 564 LLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVXVGD- 740
++ ++ LN+ VHGI + +P + V +A+ P KDVDG+ +N GRV +GD
Sbjct: 64 VIEEVLRLNKDSRVHGIFLHLP----QTFLSKSVRNAIKPQKDVDGVCDLNVGRVVLGDK 119
Query: 741 LSGFIPCTPXGCVELI 788
GF +EL+
Sbjct: 120 TDGFTSPVAGAVLELL 135
>UniRef50_Q4A6B1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma synoviae 53|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Mycoplasma synoviae (strain 53)
Length = 278
Score = 74.1 bits (174), Expect = 4e-12
Identities = 50/146 (34%), Positives = 76/146 (52%), Gaps = 3/146 (2%)
Frame = +3
Query: 360 QESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRL 539
+E E DL+Q L +LAI+QVG + +SN Y+ KLK A++IGI A+ +
Sbjct: 7 REKAEQDLKQLKKELDELNLNRPIKLAIIQVGDKMESNRYVEQKLKKAKEIGIEAKCFKF 66
Query: 540 PRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINE 719
+IT+ LL + +NE + GI++Q+PL + + DAV +KD+DGL+ NE
Sbjct: 67 DENITQKRLLLAMDEINE--NWDGILIQLPLPKH--LPKEVILDAVPYEKDIDGLSHRNE 122
Query: 720 ---GRVXVGDLSGFIPCTPXGCVELI 788
D F+P +ELI
Sbjct: 123 FILYNEKNSDDKFFVPAAARAVLELI 148
>UniRef50_A5IXS7 Cluster: FolD bifunctional protein; n=1; Mycoplasma
agalactiae|Rep: FolD bifunctional protein - Mycoplasma
agalactiae
Length = 286
Score = 73.7 bits (173), Expect = 5e-12
Identities = 49/130 (37%), Positives = 74/130 (56%), Gaps = 3/130 (2%)
Frame = +3
Query: 408 SKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKITSL 587
+K G +P L+I+QVG S++YI+ K+K AE++G+ A + DI++ LL K+ L
Sbjct: 25 TKLIGRQPVLSIIQVGDNPASSLYIKNKIKKAEELGVKATLYKFDEDISQNSLLKKLDVL 84
Query: 588 NESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGL---NTINEGRVXVGDLSGFIP 758
NE GIIVQ+PL +H I + + + +KDVDGL +T N +LS F P
Sbjct: 85 NEESD--GIIVQLPL-PEH-ISPKVIMNGIRLEKDVDGLCEKSTFNFYNDKYDELS-FTP 139
Query: 759 CTPXGCVELI 788
T ++LI
Sbjct: 140 ATAAAIIDLI 149
>UniRef50_A0DMT9 Cluster: Chromosome undetermined scaffold_57, whole
genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_57,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 309
Score = 72.5 bits (170), Expect = 1e-11
Identities = 39/121 (32%), Positives = 67/121 (55%), Gaps = 1/121 (0%)
Frame = +3
Query: 429 PRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKITSLNESPSVH 608
P LAI+QVG S Y+R K+ E+ I E P I++ E++ +I SLN+ S+
Sbjct: 37 PGLAIIQVGNNPSSLTYVRKKIALCEEHQIHHELYHFPETISQKEIVHRIKSLNQKGSID 96
Query: 609 GIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN-EGRVXVGDLSGFIPCTPXGCVEL 785
GI+VQ+PL + +++ + +KD+D L+ N + + G+ + IPCTP + +
Sbjct: 97 GILVQLPLPPH--LSRLEISNEIKLNKDIDCLHMANFQNLLQNGEDNDIIPCTPAAVLHI 154
Query: 786 I 788
+
Sbjct: 155 L 155
>UniRef50_P47259 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Mycoplasma|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma genitalium
Length = 273
Score = 72.1 bits (169), Expect = 1e-11
Identities = 38/93 (40%), Positives = 59/93 (63%)
Frame = +3
Query: 432 RLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKITSLNESPSVHG 611
+L I+Q + S+ +I+ KL A +G +E I+L IT+ EL+ KI SLN +V G
Sbjct: 25 KLVIIQANDDDSSDSFIKQKLIACNTVGAKSELIKLSNQITQAELIEKIISLNHDVNVTG 84
Query: 612 IIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 710
II+Q+P+ H +D + + +A++P KDVDGL T
Sbjct: 85 IILQLPV-YPH-LDKNSLLEAINPLKDVDGLTT 115
>UniRef50_Q7TU81 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Prochlorococcus marinus|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Prochlorococcus marinus subsp. pastoris
(strain CCMP 1378 / MED4)
Length = 298
Score = 71.3 bits (167), Expect = 3e-11
Identities = 38/120 (31%), Positives = 65/120 (54%)
Frame = +3
Query: 429 PRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKITSLNESPSVH 608
P LA++++G S VY+ K KA ++GI + L + + E+ + LN ++
Sbjct: 33 PGLAVIRIGEDPASGVYVGNKEKACSRVGIKSYIFHLKDTVEQKEVEQLLNKLNLDNNID 92
Query: 609 GIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGFIPCTPXGCVELI 788
G+++Q+P+ D R+ ++P+KDVDGLN N G++ V + CTP G V L+
Sbjct: 93 GMLLQLPISK--KFDEQRLISFINPEKDVDGLNEQNIGKL-VKNEQAMRSCTPAGIVNLL 149
>UniRef50_Q04FB7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Leuconostocaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Oenococcus oeni (strain BAA-331 / PSU-1)
Length = 285
Score = 71.3 bits (167), Expect = 3e-11
Identities = 42/142 (29%), Positives = 73/142 (51%), Gaps = 1/142 (0%)
Frame = +3
Query: 366 SIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPR 545
S+ + Q+V +K +GF +LA + E S +Y+ MK++ A G+ + ++
Sbjct: 9 SVSKKILQEVKDKVAK-AGFPVKLATIYNEENEGSKMYVGMKIRRATFAGLISVEYKVDN 67
Query: 546 DITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGR 725
++L ++ LN S+ GI+VQ PL ID ++ +A+ P KD DGL+ N+G
Sbjct: 68 SWKTDDILRLLSKLNMDSSICGILVQSPLGD--GIDESKIFNAIDPLKDADGLSAFNQGL 125
Query: 726 VXVGDLSGFI-PCTPXGCVELI 788
+ +I P TP G + L+
Sbjct: 126 LFENAKENYIVPATPAGVISLL 147
>UniRef50_Q6KID0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma mobile|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma mobile
Length = 280
Score = 71.3 bits (167), Expect = 3e-11
Identities = 44/121 (36%), Positives = 67/121 (55%)
Frame = +3
Query: 426 EPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKITSLNESPSV 605
+P IVQVG SN YI+ K+ A +IG+ + I++P I+E +L++ I ES
Sbjct: 27 KPVFTIVQVGNLFSSNKYIKTKMDKALEIGVVSRLIKIPESISEKDLISIIE--EESKIS 84
Query: 606 HGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGFIPCTPXGCVEL 785
HG+IVQ+PL D ++ ++V KD+DGL+ N + G S P T G ++L
Sbjct: 85 HGLIVQLPLPLQ--FDQSKILNSVPITKDIDGLSEKNSKNLYSGK-SCIQPATARGIIDL 141
Query: 786 I 788
I
Sbjct: 142 I 142
>UniRef50_Q979W3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermoplasma|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermoplasma volcanium
Length = 281
Score = 70.9 bits (166), Expect = 3e-11
Identities = 42/146 (28%), Positives = 78/146 (53%)
Frame = +3
Query: 351 EAVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEH 530
E + E +L++++ ++ G PRL ++QVG + +Y R K+K +KIG A
Sbjct: 9 EEIAEKKAEELKERIEKM-----GVSPRLVLLQVGNYSAATIYARAKIKRGKKIG-ADVV 62
Query: 531 IRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 710
+ D+T+ EL+ +I L+ V+GI+V+ PL ID + + ++ KDVD L+
Sbjct: 63 LEKYEDLTKQELVRRIEELSADKDVNGIMVENPLPK--TIDYYDIVKSIPYYKDVDALSP 120
Query: 711 INEGRVXVGDLSGFIPCTPXGCVELI 788
N+G + + + +P T V+++
Sbjct: 121 YNQGSIAI-NREFLVPATAMAVVDIL 145
>UniRef50_Q057D7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Enterobacteriaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Buchnera aphidicola subsp. Cinara cedri
Length = 284
Score = 67.3 bits (157), Expect = 4e-10
Identities = 39/144 (27%), Positives = 74/144 (51%)
Frame = +3
Query: 357 VQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIR 536
+ + I +++++ + + K P LA++ +G S +Y+ K +A + G + +
Sbjct: 11 ISKKIIKKIKKKIEKRKKKRKKI-PGLAMIVIGNNPASLIYVNKKREACNQAGFFSIYWH 69
Query: 537 LPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 716
L I EIEL+ I LN++ + GI++Q+PL I+ ++ ++ P KDVDG + N
Sbjct: 70 LSNQIEEIELINLIKKLNKNKCIDGILIQLPLPI--KINYLKIITSIDPKKDVDGFHPYN 127
Query: 717 EGRVXVGDLSGFIPCTPXGCVELI 788
G + + F CT G + L+
Sbjct: 128 LGSLCQNN-PQFRSCTSKGVITLL 150
>UniRef50_A0C3Q0 Cluster: Chromosome undetermined scaffold_147,
whole genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_147,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 404
Score = 66.9 bits (156), Expect = 5e-10
Identities = 41/139 (29%), Positives = 71/139 (51%), Gaps = 1/139 (0%)
Frame = +3
Query: 375 NDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDIT 554
N L + + S +P+L I VG S Y+ KLKA ++I + AE ++
Sbjct: 123 NQLANTILKTLRITSEIKPKLGICLVGDSPASKSYVNRKLKACQEINVDAEVFNFSENVG 182
Query: 555 EIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVXV 734
+ +L+ I +N GI+VQ+PL S ++ + ++ +KDVD L+ N R+ V
Sbjct: 183 QEQLIKHIQQMNHD----GILVQLPLPSH--LNKLDIIHSIPYEKDVDCLHMHNLQRILV 236
Query: 735 -GDLSGFIPCTPXGCVELI 788
G+L +PCTP ++++
Sbjct: 237 YGELCEMLPCTPAAVLQIL 255
>UniRef50_Q4DH06 Cluster: Methylenetetrahydrofolate
dehydrogenase-like protein, putative; n=1; Trypanosoma
cruzi|Rep: Methylenetetrahydrofolate dehydrogenase-like
protein, putative - Trypanosoma cruzi
Length = 375
Score = 66.5 bits (155), Expect = 7e-10
Identities = 33/98 (33%), Positives = 56/98 (57%)
Frame = +3
Query: 429 PRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKITSLNESPSVH 608
P LA+V VG R+DS Y+ +K + AE GI + LP ++E L ++ +++ +
Sbjct: 30 PSLAVVMVGNRQDSRRYVSVKQRTAEACGIRFHLLSLPETVSEERLHQELRRISDDNAFD 89
Query: 609 GIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEG 722
G+++Q+P+ S + + + P KDVDGL+ IN G
Sbjct: 90 GVLLQLPIPSHLRVRPALL--CIHPGKDVDGLHPINAG 125
>UniRef50_Q9RW02 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Deinococcus|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Deinococcus radiodurans
Length = 299
Score = 66.5 bits (155), Expect = 7e-10
Identities = 37/116 (31%), Positives = 62/116 (53%), Gaps = 1/116 (0%)
Frame = +3
Query: 423 FEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKITSLNESPS 602
FEP+L V E S VY++ K K A+K+G+A + L T+ L + L+ P+
Sbjct: 42 FEPQLVSVLASDDEASQVYVQSKAKRAKKLGVAFRVVDLGAAATQEALEQTLRELSADPA 101
Query: 603 VHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVXVG-DLSGFIPCTP 767
VHGI++++PL + +DA ++ KD++GL+ N + G + +P TP
Sbjct: 102 VHGIVLELPLAA--GLDADAALLHIAARKDIEGLSPANLALIAAGREPEALLPPTP 155
>UniRef50_Q8RDM4 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Fusobacterium nucleatum|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Fusobacterium nucleatum subsp. nucleatum
Length = 283
Score = 64.9 bits (151), Expect = 2e-09
Identities = 40/140 (28%), Positives = 70/140 (50%)
Frame = +3
Query: 369 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRD 548
I+ ++ ++ ++ K P +A + VG S VY+ ++K+ + +GI + +
Sbjct: 12 IKVKIKAEIDNIK-KIHNINPMVATILVGDDPASQVYLNSQVKSYQDLGIGVQKYFFSEE 70
Query: 549 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 728
I+E LL I LN+ V GI++ +PL I+A +V +++ KDVDG N G +
Sbjct: 71 ISEAYLLNLIDKLNKDTEVDGIMINLPLPPQ--INATKVLNSIKLIKDVDGFKAENLGLL 128
Query: 729 XVGDLSGFIPCTPXGCVELI 788
+ P TP G + LI
Sbjct: 129 FQNNEGFTSPSTPAGIMALI 148
>UniRef50_Q1AVQ0 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Rubrobacter xylanophilus DSM 9941|Rep: Bifunctional
protein folD 2 [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Rubrobacter xylanophilus
(strain DSM 9941 / NBRC 16129)
Length = 320
Score = 64.5 bits (150), Expect = 3e-09
Identities = 41/123 (33%), Positives = 60/123 (48%)
Frame = +3
Query: 420 GFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKITSLNESP 599
G P LA V VG + Y R A ++G RLPR+ E ++LA + LN P
Sbjct: 30 GVRPGLATVLVGEDYAARAYERRVGGLAAELGCRYVCERLPREAEEADVLAVVGKLNADP 89
Query: 600 SVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGFIPCTPXGCV 779
V GI+V PL I V A+ P KD++ ++ +N G + +G ++P TP C
Sbjct: 90 RVSGILVLRPLPGH--ISEPAVFSALDPLKDIEAVHPVNAGLLALG-RPRYVPSTPAACF 146
Query: 780 ELI 788
L+
Sbjct: 147 YLL 149
>UniRef50_A7AXK7 Cluster: Putative uncharacterized protein; n=1;
Ruminococcus gnavus ATCC 29149|Rep: Putative
uncharacterized protein - Ruminococcus gnavus ATCC 29149
Length = 276
Score = 61.7 bits (143), Expect = 2e-08
Identities = 42/138 (30%), Positives = 73/138 (52%), Gaps = 1/138 (0%)
Frame = +3
Query: 372 ENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDI 551
+ +L++++ L K P LA++Q+ + SN YI+ K K ++IGI H+ + +
Sbjct: 16 KKELKEEIKHLDKK-----PVLAVIQIDDDQASNSYIKGKQKDCDEIGIEMRHVNIYSNT 70
Query: 552 TEI-ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 728
TE E+ IT + +S + GII+Q+P+ + ++ R+ + P+KDVDG
Sbjct: 71 TEQKEVECVITDIAKSDA-DGIIIQLPIPDKYNLE--RLQHLIPPEKDVDGFRKD----- 122
Query: 729 XVGDLSGFIPCTPXGCVE 782
S F PCTP G ++
Sbjct: 123 -----SCFKPCTPKGIID 135
>UniRef50_Q8ZZK1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Pyrobaculum|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Pyrobaculum aerophilum
Length = 311
Score = 60.9 bits (141), Expect = 4e-08
Identities = 52/163 (31%), Positives = 74/163 (45%), Gaps = 9/163 (5%)
Frame = +3
Query: 324 IMWKNSEELEAVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGR----EDSNVYIRMK 491
+ W EEL A + R V RL G P+LA++ + E ++ +K
Sbjct: 2 VTWIRGEELHA---RTKEWARSHVKRLEEV--GITPKLAVLLLNDDPVELETQRRFVTLK 56
Query: 492 LKAAEKIGIAAEHIRL---PRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHR 662
+ +IG E L P + E L I SLN V G+I+Q PL +D
Sbjct: 57 ARDVREIGGEVEIYELYSAPPERRTKEALRLIESLNRRDDVTGVIIQKPLPP--FVDEKA 114
Query: 663 VTDAVSPDKDVDGLNTINEGRVXVG-DLS-GFIPCTPXGCVEL 785
+ A+SP+KDVD L N+ R+ DL +PCTP G +EL
Sbjct: 115 LFSALSPEKDVDALTPENKKRLLTDFDLDRDVLPCTPAGILEL 157
>UniRef50_Q8EV80 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma penetrans|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma penetrans
Length = 282
Score = 60.5 bits (140), Expect = 5e-08
Identities = 39/145 (26%), Positives = 76/145 (52%), Gaps = 1/145 (0%)
Frame = +3
Query: 357 VQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIR 536
+ +I + + + +L+ K P +AIV++ S+ Y+ +KLK A ++G+ I
Sbjct: 8 IANNILDKFKSDLEKLKKK--KIIPHMAIVKINDDAASDKYVSIKLKKAAELGVKTTLIS 65
Query: 537 LPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 716
T+ +L+ +I LN S+ G I+Q+PL D++ + + + +KD+DGL++
Sbjct: 66 -EGIKTQDDLIKQIHILNNDDSIDGYIIQLPLPK--GFDSNVICEHIDVNKDIDGLSSFA 122
Query: 717 EGR-VXVGDLSGFIPCTPXGCVELI 788
R + +L PCT G +E++
Sbjct: 123 ISRNLANSNLFHPKPCTANGIIEIL 147
>UniRef50_Q4QBW1 Cluster: Methylenetetrahydrofolate
dehydrogenase-like protein; n=2; Leishmania|Rep:
Methylenetetrahydrofolate dehydrogenase-like protein -
Leishmania major
Length = 207
Score = 60.1 bits (139), Expect = 6e-08
Identities = 37/118 (31%), Positives = 59/118 (50%)
Frame = +3
Query: 369 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRD 548
I LRQ++ R + P L +V VG DS Y+ K++AA GI + L
Sbjct: 40 ISKQLRQRI-RASTSVLRRPPCLVVVLVGDGADSIHYVNHKMRAAADCGIEVRLVHLSAT 98
Query: 549 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEG 722
+ +IEL + ++N+ V +++Q+PL + V + P KDVDGL+ +N G
Sbjct: 99 VQQIELHRTLAAVNDDVEVDAVLLQLPLPPHQRTRSALV--HIHPGKDVDGLHPLNAG 154
>UniRef50_Q9X288 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Thermotogaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermotoga maritima
Length = 271
Score = 60.1 bits (139), Expect = 6e-08
Identities = 41/148 (27%), Positives = 74/148 (50%)
Frame = +3
Query: 345 ELEAVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAA 524
+ + + SIE +++V +L GF P+L V + Y++ + K AEK+GIA
Sbjct: 4 DCKTIARSIEERTKERVEKL-----GFTPKLVSVACTDDPSALSYLKSQRKKAEKLGIAF 58
Query: 525 EHIRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGL 704
E + +++ E+++ + L SV+G+ V P +D + +V +KDV+G+
Sbjct: 59 EIM----NVSPEEIVSTLKKLGSDESVNGVFVARPFPL--GLDEKEILSSVPVEKDVEGV 112
Query: 705 NTINEGRVXVGDLSGFIPCTPXGCVELI 788
N N G + + D F PCT V ++
Sbjct: 113 NPANLG-LLLYDEEIFPPCTAEAAVRIL 139
>UniRef50_Q6L046 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermoplasmatales|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Picrophilus torridus
Length = 276
Score = 55.6 bits (128), Expect = 1e-06
Identities = 33/144 (22%), Positives = 75/144 (52%)
Frame = +3
Query: 357 VQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIR 536
+ E+ L+ ++ ++++ +G P++ I+ +G S VY + K++ K+GI + R
Sbjct: 8 ISETKMERLKNEIEKIKN--TGINPKMKIILIGNDYGSVVYSKAKMRRGSKLGIDVDLDR 65
Query: 537 LPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 716
I+ +L+ + ++S +HGI+++ P+ I+ + V + + KDVDG+ + N
Sbjct: 66 YD-SISREDLIKLLKRYSQSDDIHGIMIETPVPG---INYYDVVNEIPFYKDVDGMTSYN 121
Query: 717 EGRVXVGDLSGFIPCTPXGCVELI 788
G + + + P T V+++
Sbjct: 122 LGNLYLKN-EFIAPATARAVVDIL 144
>UniRef50_Q2JCX4 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Frankia|Rep: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Frankia sp. (strain CcI3)
Length = 276
Score = 55.2 bits (127), Expect = 2e-06
Identities = 38/124 (30%), Positives = 61/124 (49%)
Frame = +3
Query: 417 SGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKITSLNES 596
+G P LA+V + Y + + A K+G+ + P+ +L I ++
Sbjct: 27 AGVTPTLAVVLPTADPAAYSYAEIIERTAGKVGVHCV-LHEPKG-EPAAILDTIDTVAAD 84
Query: 597 PSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGFIPCTPXGC 776
P+VHGIIVQ PL + + V + + KDVDG+N + GR+ +G L F P T
Sbjct: 85 PTVHGIIVQTPLPG--GLTSREVGEHIPTAKDVDGMNPSSLGRLALG-LPSFAPATAAAV 141
Query: 777 VELI 788
VE++
Sbjct: 142 VEIL 145
>UniRef50_Q6X5D4 Cluster: Methylene-THF dehydrogenase; n=1;
Treponema primitia|Rep: Methylene-THF dehydrogenase -
Treponema primitia
Length = 97
Score = 50.8 bits (116), Expect = 4e-05
Identities = 28/91 (30%), Positives = 47/91 (51%)
Frame = +3
Query: 351 EAVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEH 530
+ V ++ L++ V L++K G P L I+++G + Y + K AE++G A ++
Sbjct: 8 KVVAAALAESLKKDVEALKAK--GVTPTLGIIRLGEKGPDISYEKGATKRAEEVGAAVKN 65
Query: 531 IRLPRDITEIELLAKITSLNESPSVHGIIVQ 623
LP D T+ LL I N+ VHG + Q
Sbjct: 66 YILPEDTTQEALLKVIKEANDDKGVHGCLAQ 96
>UniRef50_A4M873 Cluster: Tetrahydrofolate
dehydrogenase/cyclohydrolase; n=1; Petrotoga mobilis
SJ95|Rep: Tetrahydrofolate dehydrogenase/cyclohydrolase
- Petrotoga mobilis SJ95
Length = 273
Score = 49.2 bits (112), Expect = 1e-04
Identities = 35/143 (24%), Positives = 71/143 (49%), Gaps = 1/143 (0%)
Frame = +3
Query: 363 ESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLP 542
++I ++++ +++ L+ K +EP+L + V E + Y+ + + A+K GI E +
Sbjct: 6 DNIIDEIKAEISSLKEKVP-YEPKLVSLVVEPDESTKSYLNSQKRNAKKFGINLEIVE-S 63
Query: 543 RDITEIELLAKITSLNESPSVHGIIVQMPLDSDHA-IDAHRVTDAVSPDKDVDGLNTINE 719
D+T + NE I + PL + +D + ++P+KDV+G++ N
Sbjct: 64 NDLTN-----DLRKYNEDDDTDAIFIARPLKKGYTELD---IAKYINPEKDVEGVSLHNI 115
Query: 720 GRVXVGDLSGFIPCTPXGCVELI 788
G + + F+PCT V++I
Sbjct: 116 GSMFY-EKELFVPCTAEAVVKII 137
>UniRef50_Q98QV3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma pulmonis|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma pulmonis
Length = 272
Score = 47.6 bits (108), Expect = 4e-04
Identities = 34/124 (27%), Positives = 65/124 (52%), Gaps = 3/124 (2%)
Frame = +3
Query: 357 VQESIENDLRQ-QVTRLRSKWSGFEPRL--AIVQVGGREDSNVYIRMKLKAAEKIGIAAE 527
+++ + N+L Q + L+ K+S + ++ AIV +G S +Y++ K++ A+ IG+ A+
Sbjct: 2 MKKLLSNELVQIKRAELKEKFSKLDQKVKFAIVLIGDNASSKIYVKKKIEFAQDIGVEAK 61
Query: 528 HIRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLN 707
++ + LL K GII+Q+P+ D + + + +KD+DGLN
Sbjct: 62 LFHFEENV-DFNLL-KDAFKKIDKEYDGIILQLPV---LHFDVNELLLMIDKNKDLDGLN 116
Query: 708 TINE 719
NE
Sbjct: 117 PENE 120
>UniRef50_Q2UUX1 Cluster: RIB40 genomic DNA, SC009; n=1; Aspergillus
oryzae|Rep: RIB40 genomic DNA, SC009 - Aspergillus
oryzae
Length = 275
Score = 47.2 bits (107), Expect = 5e-04
Identities = 39/122 (31%), Positives = 59/122 (48%), Gaps = 10/122 (8%)
Frame = +3
Query: 432 RLAIVQVGGRED--SNVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKITSLNESPSV 605
RL ++ V +D SN Y K ++IG+ H L + ++ + I ++N + SV
Sbjct: 32 RLFLMGVLASDDAGSNQYANWTRKTCQEIGV---HFHLMK-LSPKNVATYIRAINANNSV 87
Query: 606 HGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVX-VGDLS-------GFIPC 761
HGIIV P+ D D + V+P KDV+GLN R+ ++S IPC
Sbjct: 88 HGIIVYYPIFGDRRDD--EIRQLVAPSKDVEGLNHQTLHRISDAAEVSRPPKPGRNVIPC 145
Query: 762 TP 767
TP
Sbjct: 146 TP 147
>UniRef50_Q5KEZ0 Cluster: Methylenetetrahydrofolate dehydrogenase
(NAD+), putative; n=1; Filobasidiella neoformans|Rep:
Methylenetetrahydrofolate dehydrogenase (NAD+), putative
- Cryptococcus neoformans (Filobasidiella neoformans)
Length = 367
Score = 45.6 bits (103), Expect = 0.001
Identities = 35/107 (32%), Positives = 50/107 (46%), Gaps = 8/107 (7%)
Frame = +3
Query: 411 KWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITE--------IEL 566
++S P L + +ED+ Y KA E +GI E +RL + E IE+
Sbjct: 28 RFSSRPPHLVGILATKKEDARTYAEFTKKACETLGITYE-LRLVGEAREGMDGEGVGIEV 86
Query: 567 LAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLN 707
I NE P V G++V P+ D + + VSP KDV+GLN
Sbjct: 87 EEAILEANEDPEVDGMMVYYPIYGGRQ-DQY-LQSVVSPQKDVEGLN 131
>UniRef50_Q54Z91 Cluster: Methylenetetrahydrofolate dehydrogenase;
n=2; Dictyostelium discoideum|Rep:
Methylenetetrahydrofolate dehydrogenase - Dictyostelium
discoideum AX4
Length = 313
Score = 45.2 bits (102), Expect = 0.002
Identities = 44/161 (27%), Positives = 76/161 (47%), Gaps = 9/161 (5%)
Frame = +3
Query: 333 KNSEELEAVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 512
K ++ + +++QQ+T+ + W +PR+ + + Y + A +K
Sbjct: 12 KGKVDVTPIANFFREEVKQQITK--NCW---KPRVVAFLTSDDQGAIDYSKWTKLACQKD 66
Query: 513 GIAAEHIRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKD 692
GI E I L R + ++L I N VHGI+V P+ +D++ + D VSP KD
Sbjct: 67 GI--EFI-LKR-VERVDLEDLIIEANNDSCVHGILVYYPVFGG-MMDSY-LQDVVSPTKD 120
Query: 693 VDGLNTINEGRV--XVGDLSG-------FIPCTPXGCVELI 788
++GL+T N + + + G IPCTP V++I
Sbjct: 121 IEGLSTQNRFNLYHNIRFMDGETATKKCVIPCTPLAMVKII 161
>UniRef50_Q4VDG8 Cluster: Putative methylene tetrahydrofolate
dehydrogenase; n=1; Hyaloperonospora parasitica|Rep:
Putative methylene tetrahydrofolate dehydrogenase -
Hyaloperonospora parasitica
Length = 328
Score = 43.6 bits (98), Expect = 0.006
Identities = 43/162 (26%), Positives = 68/162 (41%), Gaps = 14/162 (8%)
Frame = +3
Query: 345 ELEAVQESIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAA 524
+ + E + +RQ + +G P+L + G + Y KA + GI
Sbjct: 20 DASTIAEPFSSAVRQYIEH---DMAGVGPKLIGLLAHGDPAAKKYAEWTGKACARDGIRY 76
Query: 525 EHIRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDH------AIDAHRVTDAVSPD 686
E +P+D +LLA + NE P VHGI+V P +D + D++S
Sbjct: 77 ELREVPKD----DLLAALQQANEDPDVHGILVYYPCFGTFPSFFGGTMDDF-LRDSISIK 131
Query: 687 KDVDGLNTINEGRV-----XVGD---LSGFIPCTPXGCVELI 788
KDV+GL G + V D +PCTP V+++
Sbjct: 132 KDVEGLGQFYRGNLYRNIRYVDDEKTQKCVLPCTPLAIVKIL 173
>UniRef50_Q8W528 Cluster: Methylenetetrahydrofolate
dehydrogenase/methylenetetrahydrofolate cylcohydrolase
isoform 1; n=11; Viridiplantae|Rep:
Methylenetetrahydrofolate
dehydrogenase/methylenetetrahydrofolate cylcohydrolase
isoform 1 - Zea mays (Maize)
Length = 160
Score = 41.9 bits (94), Expect = 0.018
Identities = 17/36 (47%), Positives = 26/36 (72%), Gaps = 1/36 (2%)
Frame = +3
Query: 684 DKDVDGLNTINEGRVXV-GDLSGFIPCTPXGCVELI 788
+KDVDG + +N G++ + G F+PCTP GC+EL+
Sbjct: 1 EKDVDGFHPLNIGKLAMKGRQPLFLPCTPKGCIELL 36
>UniRef50_Q8KEH0 Cluster: Methylenetetrahydrofolate dehydrogenase;
n=1; Chlorobaculum tepidum|Rep:
Methylenetetrahydrofolate dehydrogenase - Chlorobium
tepidum
Length = 296
Score = 36.7 bits (81), Expect = 0.66
Identities = 24/81 (29%), Positives = 39/81 (48%), Gaps = 8/81 (9%)
Frame = +3
Query: 570 AKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVXVGD--- 740
A + + N +VHGI V P+ D DA + D +SP KDV+GL+ ++ +
Sbjct: 71 ATLEAANRDSAVHGIFVYYPIWGDKR-DAE-LRDLISPHKDVEGLSPHWIKKLYANERFD 128
Query: 741 -----LSGFIPCTPXGCVELI 788
+PCTP ++L+
Sbjct: 129 DTERRFKSILPCTPLAIIKLL 149
>UniRef50_A6RR95 Cluster: Putative uncharacterized protein; n=1;
Botryotinia fuckeliana B05.10|Rep: Putative
uncharacterized protein - Botryotinia fuckeliana B05.10
Length = 923
Score = 35.1 bits (77), Expect = 2.0
Identities = 36/139 (25%), Positives = 67/139 (48%), Gaps = 4/139 (2%)
Frame = +3
Query: 318 IRIMWKNSEELEAVQESIEN--DLRQQVTRLRSKWSGFEPRLAIVQVG--GREDSNVYIR 485
I ++ +N L+ +Q+S+ N D+R V L+ SG + V+ G G S Y
Sbjct: 323 IFLLPENGPVLQEIQKSLRNVKDIRTVVIHLQKGISGGSAKATAVKSGVWGSILSFTYHS 382
Query: 486 MKLKAAEKIGIAAEHIRLPRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRV 665
+K+ A + G+A + + I +LL + T N+ + G + +D + +++ HRV
Sbjct: 383 LKILEALR-GLAGD-----KTIISGKLLGE-TRPNDLLGI-GQAITETIDFERSVEQHRV 434
Query: 666 TDAVSPDKDVDGLNTINEG 722
T D ++DG+ +G
Sbjct: 435 TVRQGVDPELDGMKRTYDG 453
>UniRef50_Q96Q89-2 Cluster: Isoform 2 of Q96Q89 ; n=1; Homo
sapiens|Rep: Isoform 2 of Q96Q89 - Homo sapiens (Human)
Length = 1853
Score = 33.9 bits (74), Expect = 4.7
Identities = 34/141 (24%), Positives = 70/141 (49%), Gaps = 5/141 (3%)
Frame = +3
Query: 300 VIKILRIRIMWKNSEELEAVQESIENDL---RQQVTRLRSKWSGFEPRLAIVQVGGREDS 470
+ +I IR++ +N+E L A +IEN+L +++ L + F+ L++ + S
Sbjct: 904 IAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLS 963
Query: 471 NVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKITSLNESP--SVHGIIVQMPLDSDH 644
++++ I IA H++ ++ + E + K+++ E+ S+ + Q+ L
Sbjct: 964 KEV--QQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKL-MHT 1020
Query: 645 AIDAHRVTDAVSPDKDVDGLN 707
ID R D+VS ++D LN
Sbjct: 1021 KIDELRTLDSVSQISNIDLLN 1041
>UniRef50_Q4S5A6 Cluster: Chromosome 19 SCAF14731, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 19
SCAF14731, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 503
Score = 33.9 bits (74), Expect = 4.7
Identities = 30/118 (25%), Positives = 53/118 (44%), Gaps = 2/118 (1%)
Frame = +3
Query: 18 GASTKFKSLFYSMKAKYLI*IQARTIHLHETKRYQRKFVKLMY*NIKPVCPCLFKCLKPV 197
G K LF+S + + L Q R L ++ Q++ V+L + K + L KC+ +
Sbjct: 388 GKGKKLNKLFFSPEQEMLESCQTRVSKLELQQQQQQQTVQLENTDAKVL---LGKCINIM 444
Query: 198 LLVCQT*LDVFVCSAF*CKISCS--RNRRICIYCCIVIKILRIRIMWKNSEELEAVQE 365
L + + VC + K + R+R C+ + +L + +WKN E L+ E
Sbjct: 445 LAIVTV---ILVCVSMVAKFTAPLLRSRLHLALTCVGVSVLAL--LWKNWEHLQCALE 497
>UniRef50_Q96Q89 Cluster: M-phase phosphoprotein 1; n=11;
Eumetazoa|Rep: M-phase phosphoprotein 1 - Homo sapiens
(Human)
Length = 1820
Score = 33.9 bits (74), Expect = 4.7
Identities = 34/141 (24%), Positives = 70/141 (49%), Gaps = 5/141 (3%)
Frame = +3
Query: 300 VIKILRIRIMWKNSEELEAVQESIENDL---RQQVTRLRSKWSGFEPRLAIVQVGGREDS 470
+ +I IR++ +N+E L A +IEN+L +++ L + F+ L++ + S
Sbjct: 871 IAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLS 930
Query: 471 NVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKITSLNESP--SVHGIIVQMPLDSDH 644
++++ I IA H++ ++ + E + K+++ E+ S+ + Q+ L
Sbjct: 931 KEV--QQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKL-MHT 987
Query: 645 AIDAHRVTDAVSPDKDVDGLN 707
ID R D+VS ++D LN
Sbjct: 988 KIDELRTLDSVSQISNIDLLN 1008
>UniRef50_Q7NAE4 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Mycoplasma gallisepticum|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Mycoplasma gallisepticum
Length = 283
Score = 33.9 bits (74), Expect = 4.7
Identities = 20/99 (20%), Positives = 47/99 (47%)
Frame = +3
Query: 402 LRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITEIELLAKIT 581
L K + + ++ I+ E S +Y+R K+ + +GI E L + + + ++
Sbjct: 18 LAKKVNNQKIKILIIISDPSEASRIYVRNKINYCDSLGIQTEVYDLSKIDDTNQFIVEMN 77
Query: 582 SLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVD 698
+ +G++VQ+P+ +D +++ + + DVD
Sbjct: 78 QKISLSNPNGVLVQLPI--KERLDTNKIIENIPIRLDVD 114
>UniRef50_Q1IRB8 Cluster: Putative uncharacterized protein
precursor; n=1; Acidobacteria bacterium Ellin345|Rep:
Putative uncharacterized protein precursor -
Acidobacteria bacterium (strain Ellin345)
Length = 314
Score = 33.1 bits (72), Expect = 8.2
Identities = 14/43 (32%), Positives = 25/43 (58%)
Frame = -3
Query: 458 PAHLHDGKPGLEARPF*TEPSHLLTQVIFYRFLHSFQFFRILP 330
P+ LH+ + GL+ R F E ++L ++F+ L +F +LP
Sbjct: 2 PSELHNSEQGLKRRSFRAESGYMLLILMFFVALLTFSLMAVLP 44
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 713,760,012
Number of Sequences: 1657284
Number of extensions: 13701621
Number of successful extensions: 32137
Number of sequences better than 10.0: 109
Number of HSP's better than 10.0 without gapping: 31001
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 32005
length of database: 575,637,011
effective HSP length: 99
effective length of database: 411,565,895
effective search space used: 67085240885
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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