Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fcaL-P04_F_E06
(840 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
X05344-1|CAA28955.1| 412|Homo sapiens cathepsin D protein. 235 1e-61
M63138-1|AAA51922.1| 412|Homo sapiens cathepsin D protein. 235 1e-61
M11233-1|AAB59529.1| 412|Homo sapiens CTSD protein. 235 1e-61
CR456947-1|CAG33228.1| 412|Homo sapiens CTSD protein. 235 1e-61
BT020155-1|AAV38957.1| 412|Homo sapiens cathepsin D (lysosomal ... 235 1e-61
BT006910-1|AAP35556.1| 412|Homo sapiens cathepsin D (lysosomal ... 235 1e-61
BC016320-1|AAH16320.1| 412|Homo sapiens cathepsin D protein. 235 1e-61
BC017842-1|AAH17842.1| 420|Homo sapiens napsin A aspartic pepti... 209 8e-54
AF200345-1|AAF17081.1| 420|Homo sapiens aspartyl protease 4 pro... 209 1e-53
AF098484-1|AAD13215.1| 420|Homo sapiens napsin 1 precursor prot... 209 1e-53
AF090386-1|AAD04917.1| 420|Homo sapiens napsin A protein. 209 1e-53
BC111705-1|AAI11706.1| 464|Homo sapiens NAPSB protein protein. 190 4e-48
AF200344-1|AAF17080.1| 450|Homo sapiens aspartyl protease 3 pro... 190 4e-48
M84424-1|AAA52300.1| 396|Homo sapiens cathepsin E protein. 188 2e-47
J05036-1|AAA52130.1| 396|Homo sapiens CTSE protein. 188 2e-47
BX571818-5|CAH73265.1| 363|Homo sapiens cathepsin E protein. 188 2e-47
BX571818-4|CAH73264.1| 396|Homo sapiens cathepsin E protein. 188 2e-47
BC042537-1|AAH42537.1| 396|Homo sapiens cathepsin E protein. 188 2e-47
AJ250717-1|CAB82850.1| 396|Homo sapiens procathepsin E protein. 188 2e-47
AJ250716-1|CAB82849.1| 363|Homo sapiens cathepsin E, alternativ... 188 2e-47
M10152-1|AAD03461.1| 406|Homo sapiens renin protein. 187 4e-47
L00073-1|AAA60363.1| 406|Homo sapiens renin protein. 187 4e-47
CR536498-1|CAG38737.1| 406|Homo sapiens REN protein. 187 4e-47
BC047752-1|AAH47752.1| 406|Homo sapiens renin protein. 187 4e-47
BC033474-1|AAH33474.1| 406|Homo sapiens renin protein. 187 4e-47
AL592146-1|CAI16594.1| 406|Homo sapiens renin protein. 187 4e-47
AL592114-1|CAH71224.1| 406|Homo sapiens renin protein. 187 4e-47
M26901-1|AAA60364.1| 403|Homo sapiens renin protein. 185 2e-46
AY436324-1|AAR03502.1| 403|Homo sapiens renin protein. 185 2e-46
U75272-1|AAB18273.1| 388|Homo sapiens gastricsin protein. 173 9e-43
M23077-1|AAA60063.1| 388|Homo sapiens pepsinogen C protein. 173 9e-43
M18667-1|AAA60062.1| 385|Homo sapiens pepsinogen protein. 173 9e-43
J04443-1|AAA60074.1| 388|Homo sapiens pepsinogen protein. 173 9e-43
BC073740-1|AAH73740.1| 388|Homo sapiens progastricsin (pepsinog... 173 9e-43
AL365205-1|CAI13181.1| 388|Homo sapiens progastricsin (pepsinog... 173 9e-43
J00287-1|AAA98529.1| 388|Homo sapiens PEP protein. 169 1e-41
BC029055-1|AAH29055.1| 388|Homo sapiens pepsinogen 5, group I (... 169 1e-41
M26032-1|AAA60061.1| 388|Homo sapiens pepsinogen A protein. 167 4e-41
X00063-1|CAA24937.1| 300|Homo sapiens protein ( Human kidney mR... 133 7e-31
BC014453-1|AAH14453.1| 518|Homo sapiens beta-site APP-cleaving ... 71 7e-12
AY358927-1|AAQ89286.1| 518|Homo sapiens BACE2 protein. 71 7e-12
AF212252-1|AAG41783.1| 439|Homo sapiens CDA13 protein. 71 7e-12
AF204944-1|AAF26368.1| 518|Homo sapiens transmembrane aspartic ... 71 7e-12
AF200342-1|AAF17078.1| 518|Homo sapiens aspartyl protease 1 pro... 71 7e-12
AF200192-1|AAF13714.1| 518|Homo sapiens memapsin 1 protein. 71 7e-12
AF188277-1|AAF35836.1| 396|Homo sapiens aspartyl protease protein. 71 7e-12
AF188276-1|AAF35835.1| 468|Homo sapiens aspartyl protease protein. 71 7e-12
AF178532-1|AAF29494.1| 518|Homo sapiens aspartyl protease protein. 71 7e-12
AF117892-1|AAD45240.1| 518|Homo sapiens aspartic-like protease ... 71 7e-12
AF050171-1|AAD45963.1| 518|Homo sapiens aspartyl protease protein. 71 7e-12
AK075539-1|BAC11682.1| 423|Homo sapiens protein ( Homo sapiens ... 69 2e-11
DQ007053-1|AAY16982.1| 501|Homo sapiens beta-site APP-cleaving ... 66 1e-10
BC065492-1|AAH65492.1| 501|Homo sapiens beta-site APP-cleaving ... 66 1e-10
AF204943-1|AAF26367.1| 501|Homo sapiens transmembrane aspartic ... 66 1e-10
AF201468-1|AAF18982.1| 501|Homo sapiens APP beta-secretase prot... 66 1e-10
AF200343-1|AAF17079.1| 501|Homo sapiens aspartyl protease 2 pro... 66 1e-10
AF200193-1|AAF13715.1| 488|Homo sapiens memapsin 2 protein. 66 1e-10
AF190725-1|AAF04142.1| 501|Homo sapiens beta-site APP cleaving ... 66 1e-10
AB032975-1|BAA86463.2| 532|Homo sapiens KIAA1149 protein protein. 66 1e-10
BC036084-1|AAH36084.1| 501|Homo sapiens beta-site APP-cleaving ... 64 8e-10
AL365205-2|CAI95135.1| 140|Homo sapiens progastricsin (pepsinog... 62 3e-09
BC042578-1|AAH42578.1| 104|Homo sapiens PGC protein protein. 60 1e-08
AF338816-1|AAK38374.1| 476|Homo sapiens beta-site APP cleaving ... 55 3e-07
AB050436-1|BAB40931.1| 476|Homo sapiens beta-site APP cleaving ... 55 3e-07
AL163285-1|CAB90554.1| 415|Homo sapiens beta-site APP-cleaving ... 54 6e-07
AB177847-1|BAD66825.1| 396|Homo sapiens KIAA1149 splice variant... 41 0.005
AB050438-1|BAB40933.1| 432|Homo sapiens beta-site APP cleaving ... 41 0.005
AF338817-1|AAK38375.1| 457|Homo sapiens beta-site APP cleaving ... 41 0.006
AB050437-1|BAB40932.1| 457|Homo sapiens beta-site APP cleaving ... 41 0.006
AL365205-3|CAM16152.1| 86|Homo sapiens progastricsin (pepsinog... 39 0.026
AB089958-1|BAC81826.1| 127|Homo sapiens beta-site APP cleaving ... 36 0.24
BC104851-1|AAI04852.1| 147|Homo sapiens LOC283174 protein protein. 31 5.2
BC101691-1|AAI01692.1| 147|Homo sapiens LOC283174 protein protein. 31 5.2
BC030606-1|AAH30606.2| 514|Homo sapiens coiled-coil domain cont... 31 6.9
>X05344-1|CAA28955.1| 412|Homo sapiens cathepsin D protein.
Length = 412
Score = 235 bits (576), Expect = 1e-61
Identities = 125/229 (54%), Positives = 153/229 (66%), Gaps = 23/229 (10%)
Frame = +3
Query: 213 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 359
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 360 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTS 539
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS++
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 540 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 686
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 687 VAAKFDGILGMAFSTIAVDHVTPVFDNMVAQGLVXP-VFSFYLNRDPGA 830
+AAKFDGILGMA+ I+V++V PVFDN++ Q LV +FSFYL+RDP A
Sbjct: 191 IAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDA 239
>M63138-1|AAA51922.1| 412|Homo sapiens cathepsin D protein.
Length = 412
Score = 235 bits (576), Expect = 1e-61
Identities = 125/229 (54%), Positives = 153/229 (66%), Gaps = 23/229 (10%)
Frame = +3
Query: 213 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 359
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 360 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTS 539
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS++
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 540 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 686
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 687 VAAKFDGILGMAFSTIAVDHVTPVFDNMVAQGLVXP-VFSFYLNRDPGA 830
+AAKFDGILGMA+ I+V++V PVFDN++ Q LV +FSFYL+RDP A
Sbjct: 191 IAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDA 239
>M11233-1|AAB59529.1| 412|Homo sapiens CTSD protein.
Length = 412
Score = 235 bits (576), Expect = 1e-61
Identities = 125/229 (54%), Positives = 153/229 (66%), Gaps = 23/229 (10%)
Frame = +3
Query: 213 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 359
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 360 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTS 539
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS++
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 540 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 686
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 687 VAAKFDGILGMAFSTIAVDHVTPVFDNMVAQGLVXP-VFSFYLNRDPGA 830
+AAKFDGILGMA+ I+V++V PVFDN++ Q LV +FSFYL+RDP A
Sbjct: 191 IAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDA 239
>CR456947-1|CAG33228.1| 412|Homo sapiens CTSD protein.
Length = 412
Score = 235 bits (576), Expect = 1e-61
Identities = 125/229 (54%), Positives = 153/229 (66%), Gaps = 23/229 (10%)
Frame = +3
Query: 213 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 359
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 360 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTS 539
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS++
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 540 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 686
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 687 VAAKFDGILGMAFSTIAVDHVTPVFDNMVAQGLVXP-VFSFYLNRDPGA 830
+AAKFDGILGMA+ I+V++V PVFDN++ Q LV +FSFYL+RDP A
Sbjct: 191 IAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDA 239
>BT020155-1|AAV38957.1| 412|Homo sapiens cathepsin D (lysosomal
aspartyl protease) protein.
Length = 412
Score = 235 bits (576), Expect = 1e-61
Identities = 125/229 (54%), Positives = 153/229 (66%), Gaps = 23/229 (10%)
Frame = +3
Query: 213 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 359
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 360 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTS 539
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS++
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 540 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 686
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 687 VAAKFDGILGMAFSTIAVDHVTPVFDNMVAQGLVXP-VFSFYLNRDPGA 830
+AAKFDGILGMA+ I+V++V PVFDN++ Q LV +FSFYL+RDP A
Sbjct: 191 IAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDA 239
>BT006910-1|AAP35556.1| 412|Homo sapiens cathepsin D (lysosomal
aspartyl protease) protein.
Length = 412
Score = 235 bits (576), Expect = 1e-61
Identities = 125/229 (54%), Positives = 153/229 (66%), Gaps = 23/229 (10%)
Frame = +3
Query: 213 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 359
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 360 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTS 539
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS++
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 540 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 686
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 687 VAAKFDGILGMAFSTIAVDHVTPVFDNMVAQGLVXP-VFSFYLNRDPGA 830
+AAKFDGILGMA+ I+V++V PVFDN++ Q LV +FSFYL+RDP A
Sbjct: 191 IAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDA 239
>BC016320-1|AAH16320.1| 412|Homo sapiens cathepsin D protein.
Length = 412
Score = 235 bits (576), Expect = 1e-61
Identities = 125/229 (54%), Positives = 153/229 (66%), Gaps = 23/229 (10%)
Frame = +3
Query: 213 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 359
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 360 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTS 539
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS++
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 540 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 686
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 687 VAAKFDGILGMAFSTIAVDHVTPVFDNMVAQGLVXP-VFSFYLNRDPGA 830
+AAKFDGILGMA+ I+V++V PVFDN++ Q LV +FSFYL+RDP A
Sbjct: 191 IAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDA 239
>BC017842-1|AAH17842.1| 420|Homo sapiens napsin A aspartic
peptidase protein.
Length = 420
Score = 209 bits (511), Expect = 8e-54
Identities = 103/207 (49%), Positives = 137/207 (66%), Gaps = 6/207 (2%)
Frame = +3
Query: 222 IASSVMALYRVPLHRMKTARTHFHEVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 386
+ S L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 19 VEPSGATLIRIPLHRVQPGRRTLNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 387 YGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQFA 566
+G I +GTPPQ+F V FDTGSSNLWVPS++CH+ ++ C LH+++D + S+S+ ANGT+FA
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFA 138
Query: 567 IQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDH 746
IQYG+G + G LS D +T+GG+K F EA+ EP L F A FDGILG+ F ++V+
Sbjct: 139 IQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHFDGILGLGFPILSVEG 198
Query: 747 VTPVFDNMVAQGLV-XPVFSFYLNRDP 824
V P D +V QGL+ PVFSFYLNRDP
Sbjct: 199 VRPPMDVLVEQGLLDKPVFSFYLNRDP 225
>AF200345-1|AAF17081.1| 420|Homo sapiens aspartyl protease 4
protein.
Length = 420
Score = 209 bits (510), Expect = 1e-53
Identities = 103/207 (49%), Positives = 137/207 (66%), Gaps = 6/207 (2%)
Frame = +3
Query: 222 IASSVMALYRVPLHRMKTARTHFHEVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 386
+ S L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 19 VEPSGATLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 387 YGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQFA 566
+G I +GTPPQ+F V FDTGSSNLWVPS++CH+ ++ C LH+++D + S+S+ ANGT+FA
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFA 138
Query: 567 IQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDH 746
IQYG+G + G LS D +T+GG+K F EA+ EP L F A FDGILG+ F ++V+
Sbjct: 139 IQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHFDGILGLGFPILSVEG 198
Query: 747 VTPVFDNMVAQGLV-XPVFSFYLNRDP 824
V P D +V QGL+ PVFSFYLNRDP
Sbjct: 199 VRPPMDVLVEQGLLDKPVFSFYLNRDP 225
>AF098484-1|AAD13215.1| 420|Homo sapiens napsin 1 precursor
protein.
Length = 420
Score = 209 bits (510), Expect = 1e-53
Identities = 103/207 (49%), Positives = 137/207 (66%), Gaps = 6/207 (2%)
Frame = +3
Query: 222 IASSVMALYRVPLHRMKTARTHFHEVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 386
+ S L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 19 VEPSGATLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 387 YGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQFA 566
+G I +GTPPQ+F V FDTGSSNLWVPS++CH+ ++ C LH+++D + S+S+ ANGT+FA
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFA 138
Query: 567 IQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDH 746
IQYG+G + G LS D +T+GG+K F EA+ EP L F A FDGILG+ F ++V+
Sbjct: 139 IQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHFDGILGLGFPILSVEG 198
Query: 747 VTPVFDNMVAQGLV-XPVFSFYLNRDP 824
V P D +V QGL+ PVFSFYLNRDP
Sbjct: 199 VRPPMDVLVEQGLLDKPVFSFYLNRDP 225
>AF090386-1|AAD04917.1| 420|Homo sapiens napsin A protein.
Length = 420
Score = 209 bits (510), Expect = 1e-53
Identities = 103/207 (49%), Positives = 137/207 (66%), Gaps = 6/207 (2%)
Frame = +3
Query: 222 IASSVMALYRVPLHRMKTARTHFHEVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 386
+ S L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 19 VEPSGATLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 387 YGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQFA 566
+G I +GTPPQ+F V FDTGSSNLWVPS++CH+ ++ C LH+++D + S+S+ ANGT+FA
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFA 138
Query: 567 IQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDH 746
IQYG+G + G LS D +T+GG+K F EA+ EP L F A FDGILG+ F ++V+
Sbjct: 139 IQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHFDGILGLGFPILSVEG 198
Query: 747 VTPVFDNMVAQGLV-XPVFSFYLNRDP 824
V P D +V QGL+ PVFSFYLNRDP
Sbjct: 199 VRPPMDVLVEQGLLDKPVFSFYLNRDP 225
>BC111705-1|AAI11706.1| 464|Homo sapiens NAPSB protein protein.
Length = 464
Score = 190 bits (464), Expect = 4e-48
Identities = 93/200 (46%), Positives = 130/200 (65%), Gaps = 6/200 (3%)
Frame = +3
Query: 243 LYRVPLHRMKTARTHFHEV---GTELELLRLKYDVTGPSPE--PLSNYLDAQYYGVISIG 407
L R+PL ++ R + + G EL +L G P PLS +LDAQY+G I +G
Sbjct: 22 LIRIPLRQVHPGRRTLNLLRGWGKPAELPKLGAPSPGDKPASVPLSKFLDAQYFGEIGLG 81
Query: 408 TPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQFAIQYGSGS 587
TPPQ+F V FDTGSSNLWVPS++CH+ ++ C H++++ S+S+ +GT+FAIQYG+G
Sbjct: 82 TPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWFHHRFNPNASSSFKPSGTKFAIQYGTGR 141
Query: 588 LSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPVFDN 767
+ G LS D +T+GG+K F EA+ E L F ++ DGILG+ F ++V+ V P D
Sbjct: 142 VDGILSEDKLTIGGIKGASVIFGEALWESSLVFTVSRPDGILGLGFPILSVEGVRPPLDV 201
Query: 768 MVAQGLV-XPVFSFYLNRDP 824
+V QGL+ PVFSFY NRDP
Sbjct: 202 LVEQGLLDKPVFSFYFNRDP 221
>AF200344-1|AAF17080.1| 450|Homo sapiens aspartyl protease 3
protein.
Length = 450
Score = 190 bits (464), Expect = 4e-48
Identities = 93/200 (46%), Positives = 130/200 (65%), Gaps = 6/200 (3%)
Frame = +3
Query: 243 LYRVPLHRMKTARTHFHEV---GTELELLRLKYDVTGPSPE--PLSNYLDAQYYGVISIG 407
L R+PL ++ R + + G EL +L G P PLS +LDAQY+G I +G
Sbjct: 26 LIRIPLRQVHPGRRTLNLLRGWGKPAELPKLGAPSPGDKPASVPLSKFLDAQYFGEIGLG 85
Query: 408 TPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQFAIQYGSGS 587
TPPQ+F V FDTGSSNLWVPS++CH+ ++ C H++++ S+S+ +GT+FAIQYG+G
Sbjct: 86 TPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWFHHRFNPNASSSFKPSGTKFAIQYGTGR 145
Query: 588 LSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPVFDN 767
+ G LS D +T+GG+K F EA+ E L F ++ DGILG+ F ++V+ V P D
Sbjct: 146 VDGILSEDKLTIGGIKGASVIFGEALWESSLVFTVSRPDGILGLGFPILSVEGVRPPLDV 205
Query: 768 MVAQGLV-XPVFSFYLNRDP 824
+V QGL+ PVFSFY NRDP
Sbjct: 206 LVEQGLLDKPVFSFYFNRDP 225
>M84424-1|AAA52300.1| 396|Homo sapiens cathepsin E protein.
Length = 396
Score = 188 bits (459), Expect = 2e-47
Identities = 101/218 (46%), Positives = 140/218 (64%), Gaps = 11/218 (5%)
Frame = +3
Query: 204 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 353
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 354 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 533
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 534 TSYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGIL 713
++Y G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGIL
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 185
Query: 714 GMAFSTIAVDHVTPVFDNMVAQGLV-XPVFSFYLNRDP 824
G+ + ++AV VTPVFDNM+AQ LV P+FS Y++ +P
Sbjct: 186 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNP 223
>J05036-1|AAA52130.1| 396|Homo sapiens CTSE protein.
Length = 396
Score = 188 bits (459), Expect = 2e-47
Identities = 101/218 (46%), Positives = 140/218 (64%), Gaps = 11/218 (5%)
Frame = +3
Query: 204 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 353
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 354 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 533
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 534 TSYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGIL 713
++Y G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGIL
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 185
Query: 714 GMAFSTIAVDHVTPVFDNMVAQGLV-XPVFSFYLNRDP 824
G+ + ++AV VTPVFDNM+AQ LV P+FS Y++ +P
Sbjct: 186 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNP 223
>BX571818-5|CAH73265.1| 363|Homo sapiens cathepsin E protein.
Length = 363
Score = 188 bits (459), Expect = 2e-47
Identities = 101/218 (46%), Positives = 140/218 (64%), Gaps = 11/218 (5%)
Frame = +3
Query: 204 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 353
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 354 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 533
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 534 TSYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGIL 713
++Y G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGIL
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 185
Query: 714 GMAFSTIAVDHVTPVFDNMVAQGLV-XPVFSFYLNRDP 824
G+ + ++AV VTPVFDNM+AQ LV P+FS Y++ +P
Sbjct: 186 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNP 223
>BX571818-4|CAH73264.1| 396|Homo sapiens cathepsin E protein.
Length = 396
Score = 188 bits (459), Expect = 2e-47
Identities = 101/218 (46%), Positives = 140/218 (64%), Gaps = 11/218 (5%)
Frame = +3
Query: 204 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 353
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 354 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 533
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 534 TSYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGIL 713
++Y G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGIL
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 185
Query: 714 GMAFSTIAVDHVTPVFDNMVAQGLV-XPVFSFYLNRDP 824
G+ + ++AV VTPVFDNM+AQ LV P+FS Y++ +P
Sbjct: 186 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNP 223
>BC042537-1|AAH42537.1| 396|Homo sapiens cathepsin E protein.
Length = 396
Score = 188 bits (459), Expect = 2e-47
Identities = 101/218 (46%), Positives = 140/218 (64%), Gaps = 11/218 (5%)
Frame = +3
Query: 204 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 353
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 354 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 533
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 534 TSYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGIL 713
++Y G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGIL
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 185
Query: 714 GMAFSTIAVDHVTPVFDNMVAQGLV-XPVFSFYLNRDP 824
G+ + ++AV VTPVFDNM+AQ LV P+FS Y++ +P
Sbjct: 186 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNP 223
>AJ250717-1|CAB82850.1| 396|Homo sapiens procathepsin E protein.
Length = 396
Score = 188 bits (459), Expect = 2e-47
Identities = 101/218 (46%), Positives = 140/218 (64%), Gaps = 11/218 (5%)
Frame = +3
Query: 204 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 353
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 354 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 533
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 534 TSYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGIL 713
++Y G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGIL
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 185
Query: 714 GMAFSTIAVDHVTPVFDNMVAQGLV-XPVFSFYLNRDP 824
G+ + ++AV VTPVFDNM+AQ LV P+FS Y++ +P
Sbjct: 186 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNP 223
>AJ250716-1|CAB82849.1| 363|Homo sapiens cathepsin E, alternative
protein.
Length = 363
Score = 188 bits (459), Expect = 2e-47
Identities = 101/218 (46%), Positives = 140/218 (64%), Gaps = 11/218 (5%)
Frame = +3
Query: 204 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 353
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 354 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 533
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 534 TSYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGIL 713
++Y G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+FDGIL
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGIL 185
Query: 714 GMAFSTIAVDHVTPVFDNMVAQGLV-XPVFSFYLNRDP 824
G+ + ++AV VTPVFDNM+AQ LV P+FS Y++ +P
Sbjct: 186 GLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNP 223
>M10152-1|AAD03461.1| 406|Homo sapiens renin protein.
Length = 406
Score = 187 bits (456), Expect = 4e-47
Identities = 86/155 (55%), Positives = 111/155 (71%), Gaps = 1/155 (0%)
Frame = +3
Query: 360 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTS 539
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S+S
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 540 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 719
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 720 AFSTIAVDHVTPVFDNMVAQG-LVXPVFSFYLNRD 821
F A+ VTP+FDN+++QG L VFSFY NRD
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRD 231
>L00073-1|AAA60363.1| 406|Homo sapiens renin protein.
Length = 406
Score = 187 bits (456), Expect = 4e-47
Identities = 86/155 (55%), Positives = 111/155 (71%), Gaps = 1/155 (0%)
Frame = +3
Query: 360 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTS 539
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S+S
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 540 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 719
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 720 AFSTIAVDHVTPVFDNMVAQG-LVXPVFSFYLNRD 821
F A+ VTP+FDN+++QG L VFSFY NRD
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRD 231
>CR536498-1|CAG38737.1| 406|Homo sapiens REN protein.
Length = 406
Score = 187 bits (456), Expect = 4e-47
Identities = 86/155 (55%), Positives = 111/155 (71%), Gaps = 1/155 (0%)
Frame = +3
Query: 360 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTS 539
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S+S
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 540 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 719
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 720 AFSTIAVDHVTPVFDNMVAQG-LVXPVFSFYLNRD 821
F A+ VTP+FDN+++QG L VFSFY NRD
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRD 231
>BC047752-1|AAH47752.1| 406|Homo sapiens renin protein.
Length = 406
Score = 187 bits (456), Expect = 4e-47
Identities = 86/155 (55%), Positives = 111/155 (71%), Gaps = 1/155 (0%)
Frame = +3
Query: 360 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTS 539
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S+S
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 540 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 719
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 720 AFSTIAVDHVTPVFDNMVAQG-LVXPVFSFYLNRD 821
F A+ VTP+FDN+++QG L VFSFY NRD
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRD 231
>BC033474-1|AAH33474.1| 406|Homo sapiens renin protein.
Length = 406
Score = 187 bits (456), Expect = 4e-47
Identities = 86/155 (55%), Positives = 111/155 (71%), Gaps = 1/155 (0%)
Frame = +3
Query: 360 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTS 539
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S+S
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 540 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 719
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 720 AFSTIAVDHVTPVFDNMVAQG-LVXPVFSFYLNRD 821
F A+ VTP+FDN+++QG L VFSFY NRD
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRD 231
>AL592146-1|CAI16594.1| 406|Homo sapiens renin protein.
Length = 406
Score = 187 bits (456), Expect = 4e-47
Identities = 86/155 (55%), Positives = 111/155 (71%), Gaps = 1/155 (0%)
Frame = +3
Query: 360 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTS 539
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S+S
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 540 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 719
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 720 AFSTIAVDHVTPVFDNMVAQG-LVXPVFSFYLNRD 821
F A+ VTP+FDN+++QG L VFSFY NRD
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRD 231
>AL592114-1|CAH71224.1| 406|Homo sapiens renin protein.
Length = 406
Score = 187 bits (456), Expect = 4e-47
Identities = 86/155 (55%), Positives = 111/155 (71%), Gaps = 1/155 (0%)
Frame = +3
Query: 360 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTS 539
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S+S
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 540 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 719
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 720 AFSTIAVDHVTPVFDNMVAQG-LVXPVFSFYLNRD 821
F A+ VTP+FDN+++QG L VFSFY NRD
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRD 231
>M26901-1|AAA60364.1| 403|Homo sapiens renin protein.
Length = 403
Score = 185 bits (451), Expect = 2e-46
Identities = 85/155 (54%), Positives = 111/155 (71%), Gaps = 1/155 (0%)
Frame = +3
Query: 360 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTS 539
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S+S
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 540 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 719
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAQFDGVVGM 196
Query: 720 AFSTIAVDHVTPVFDNMVAQG-LVXPVFSFYLNRD 821
F A+ VTP+FDN+++QG L VFSFY NR+
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRN 231
>AY436324-1|AAR03502.1| 403|Homo sapiens renin protein.
Length = 403
Score = 185 bits (451), Expect = 2e-46
Identities = 85/155 (54%), Positives = 111/155 (71%), Gaps = 1/155 (0%)
Frame = +3
Query: 360 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTS 539
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S+S
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 540 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGM 719
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+FDG++GM
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGM 196
Query: 720 AFSTIAVDHVTPVFDNMVAQG-LVXPVFSFYLNRD 821
F A+ VTP+FDN+++QG L VFSFY NR+
Sbjct: 197 GFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRN 231
>U75272-1|AAB18273.1| 388|Homo sapiens gastricsin protein.
Length = 388
Score = 173 bits (420), Expect = 9e-43
Identities = 93/208 (44%), Positives = 130/208 (62%), Gaps = 10/208 (4%)
Frame = +3
Query: 240 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 392
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 393 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQFAIQ 572
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S++Y NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 573 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVT 752
YGSGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEAT 193
Query: 753 PVFDNMVAQG-LVXPVFSFYLNRDPGAT 833
MV +G L PVFS YL+ G++
Sbjct: 194 TAMQGMVQEGALTSPVFSVYLSNQQGSS 221
>M23077-1|AAA60063.1| 388|Homo sapiens pepsinogen C protein.
Length = 388
Score = 173 bits (420), Expect = 9e-43
Identities = 93/208 (44%), Positives = 130/208 (62%), Gaps = 10/208 (4%)
Frame = +3
Query: 240 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 392
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 393 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQFAIQ 572
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S++Y NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 573 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVT 752
YGSGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEAT 193
Query: 753 PVFDNMVAQG-LVXPVFSFYLNRDPGAT 833
MV +G L PVFS YL+ G++
Sbjct: 194 TAMQGMVQEGALTSPVFSVYLSNQQGSS 221
>M18667-1|AAA60062.1| 385|Homo sapiens pepsinogen protein.
Length = 385
Score = 173 bits (420), Expect = 9e-43
Identities = 93/208 (44%), Positives = 130/208 (62%), Gaps = 10/208 (4%)
Frame = +3
Query: 240 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 392
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 14 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 72
Query: 393 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQFAIQ 572
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S++Y NG F++Q
Sbjct: 73 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 130
Query: 573 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVT 752
YGSGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 131 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEAT 190
Query: 753 PVFDNMVAQG-LVXPVFSFYLNRDPGAT 833
MV +G L PVFS YL+ G++
Sbjct: 191 TAMQGMVQEGALTSPVFSVYLSNQQGSS 218
>J04443-1|AAA60074.1| 388|Homo sapiens pepsinogen protein.
Length = 388
Score = 173 bits (420), Expect = 9e-43
Identities = 93/208 (44%), Positives = 130/208 (62%), Gaps = 10/208 (4%)
Frame = +3
Query: 240 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 392
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 393 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQFAIQ 572
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S++Y NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 573 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVT 752
YGSGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEAT 193
Query: 753 PVFDNMVAQG-LVXPVFSFYLNRDPGAT 833
MV +G L PVFS YL+ G++
Sbjct: 194 TAMQGMVQEGALTSPVFSVYLSNQQGSS 221
>BC073740-1|AAH73740.1| 388|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 388
Score = 173 bits (420), Expect = 9e-43
Identities = 93/208 (44%), Positives = 130/208 (62%), Gaps = 10/208 (4%)
Frame = +3
Query: 240 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 392
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 393 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQFAIQ 572
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S++Y NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 573 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVT 752
YGSGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEAT 193
Query: 753 PVFDNMVAQG-LVXPVFSFYLNRDPGAT 833
MV +G L PVFS YL+ G++
Sbjct: 194 TAMQGMVQEGALTSPVFSVYLSNQQGSS 221
>AL365205-1|CAI13181.1| 388|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 388
Score = 173 bits (420), Expect = 9e-43
Identities = 93/208 (44%), Positives = 130/208 (62%), Gaps = 10/208 (4%)
Frame = +3
Query: 240 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 392
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 393 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQFAIQ 572
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S++Y NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 573 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVT 752
YGSGSL+GF D +TV ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEAT 193
Query: 753 PVFDNMVAQG-LVXPVFSFYLNRDPGAT 833
MV +G L PVFS YL+ G++
Sbjct: 194 TAMQGMVQEGALTSPVFSVYLSNQQGSS 221
>J00287-1|AAA98529.1| 388|Homo sapiens PEP protein.
Length = 388
Score = 169 bits (410), Expect = 1e-41
Identities = 95/219 (43%), Positives = 128/219 (58%), Gaps = 13/219 (5%)
Frame = +3
Query: 204 LFFLALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRL-------KYDVTGPSP--- 353
L L L+A S +Y+VPL R K+ R E G + L+ KY +P
Sbjct: 4 LLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPTLV 63
Query: 354 --EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSR 527
+PL NYLD +Y+G I IGTP Q F VVFDTGSSNLWVPS C +++AC HN+++
Sbjct: 64 DEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYC--SSLACTNHNRFNPE 121
Query: 528 KSTSYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDG 707
S++Y + +I YG+GS++G L D V VGG+ Q F + +EPG A FDG
Sbjct: 122 DSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDG 181
Query: 708 ILGMAFSTIAVDHVTPVFDNMVAQGLVX-PVFSFYLNRD 821
ILG+A+ +I+ TPVFDN+ QGLV +FS YL+ D
Sbjct: 182 ILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSAD 220
>BC029055-1|AAH29055.1| 388|Homo sapiens pepsinogen 5, group I
(pepsinogen A) protein.
Length = 388
Score = 169 bits (410), Expect = 1e-41
Identities = 95/219 (43%), Positives = 128/219 (58%), Gaps = 13/219 (5%)
Frame = +3
Query: 204 LFFLALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRL-------KYDVTGPSP--- 353
L L L+A S +Y+VPL R K+ R E G + L+ KY +P
Sbjct: 4 LLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPTLV 63
Query: 354 --EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSR 527
+PL NYLD +Y+G I IGTP Q F VVFDTGSSNLWVPS C +++AC HN+++
Sbjct: 64 DEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYC--SSLACTNHNRFNPE 121
Query: 528 KSTSYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDG 707
S++Y + +I YG+GS++G L D V VGG+ Q F + +EPG A FDG
Sbjct: 122 DSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDG 181
Query: 708 ILGMAFSTIAVDHVTPVFDNMVAQGLVX-PVFSFYLNRD 821
ILG+A+ +I+ TPVFDN+ QGLV +FS YL+ D
Sbjct: 182 ILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSAD 220
>M26032-1|AAA60061.1| 388|Homo sapiens pepsinogen A protein.
Length = 388
Score = 167 bits (406), Expect = 4e-41
Identities = 94/219 (42%), Positives = 128/219 (58%), Gaps = 13/219 (5%)
Frame = +3
Query: 204 LFFLALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRL-------KYDVTGPSP--- 353
L L L+A S +Y+VPL R K+ R E G + L+ KY +P
Sbjct: 4 LLLLGLVALSECIMYKVPLIRKKSFRRTLSERGLLKDFLKKHNLNPARKYFPQWKAPTLV 63
Query: 354 --EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSR 527
+PL NYLD +Y+G I IGTP Q F V+FDTGSSNLWVPS C +++AC HN+++
Sbjct: 64 DEQPLENYLDMEYFGTIGIGTPAQDFTVLFDTGSSNLWVPSVYC--SSLACTNHNRFNPE 121
Query: 528 KSTSYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDG 707
S++Y + +I YG+GS++G L D V VGG+ Q F + +EPG A FDG
Sbjct: 122 DSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDG 181
Query: 708 ILGMAFSTIAVDHVTPVFDNMVAQGLVX-PVFSFYLNRD 821
ILG+A+ +I+ TPVFDN+ QGLV +FS YL+ D
Sbjct: 182 ILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSAD 220
>X00063-1|CAA24937.1| 300|Homo sapiens protein ( Human kidney mRNA
fragment for renin (aa 105-401). ).
Length = 300
Score = 133 bits (322), Expect = 7e-31
Identities = 62/125 (49%), Positives = 84/125 (67%), Gaps = 1/125 (0%)
Frame = +3
Query: 450 SNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQFAIQYGSGSLSGFLSTDDVTVGG 629
SN+WVPS KC AC+ H +D+ S+SY NGT+ ++Y +G++SGFLS D +TVGG
Sbjct: 1 SNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGG 60
Query: 630 LKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPVFDNMVAQG-LVXPVFSF 806
+ V Q F E P L F+ A+FDG++GM F A+ VTP+FDN+++QG L VFSF
Sbjct: 61 ITV-TQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSF 119
Query: 807 YLNRD 821
Y NRD
Sbjct: 120 YYNRD 124
>BC014453-1|AAH14453.1| 518|Homo sapiens beta-site APP-cleaving
enzyme 2 protein.
Length = 518
Score = 70.5 bits (165), Expect = 7e-12
Identities = 46/147 (31%), Positives = 75/147 (51%), Gaps = 4/147 (2%)
Frame = +3
Query: 384 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQF 563
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S++Y + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 564 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 737
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 738 --VDHVTPVFDNMVAQGLVXPVFSFYL 812
+ FD++V Q + VFS +
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFSMQM 232
>AY358927-1|AAQ89286.1| 518|Homo sapiens BACE2 protein.
Length = 518
Score = 70.5 bits (165), Expect = 7e-12
Identities = 46/147 (31%), Positives = 75/147 (51%), Gaps = 4/147 (2%)
Frame = +3
Query: 384 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQF 563
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S++Y + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 564 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 737
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 738 --VDHVTPVFDNMVAQGLVXPVFSFYL 812
+ FD++V Q + VFS +
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFSMQM 232
>AF212252-1|AAG41783.1| 439|Homo sapiens CDA13 protein.
Length = 439
Score = 70.5 bits (165), Expect = 7e-12
Identities = 46/147 (31%), Positives = 75/147 (51%), Gaps = 4/147 (2%)
Frame = +3
Query: 384 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQF 563
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S++Y + G
Sbjct: 13 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 66
Query: 564 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 737
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 67 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 126
Query: 738 --VDHVTPVFDNMVAQGLVXPVFSFYL 812
+ FD++V Q + VFS +
Sbjct: 127 KPSSSLETFFDSLVTQANIPNVFSMQM 153
>AF204944-1|AAF26368.1| 518|Homo sapiens transmembrane aspartic
proteinase Asp 1 protein.
Length = 518
Score = 70.5 bits (165), Expect = 7e-12
Identities = 46/147 (31%), Positives = 75/147 (51%), Gaps = 4/147 (2%)
Frame = +3
Query: 384 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQF 563
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S++Y + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 564 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 737
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 738 --VDHVTPVFDNMVAQGLVXPVFSFYL 812
+ FD++V Q + VFS +
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFSMQM 232
>AF200342-1|AAF17078.1| 518|Homo sapiens aspartyl protease 1
protein.
Length = 518
Score = 70.5 bits (165), Expect = 7e-12
Identities = 46/147 (31%), Positives = 75/147 (51%), Gaps = 4/147 (2%)
Frame = +3
Query: 384 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQF 563
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S++Y + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 564 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 737
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 738 --VDHVTPVFDNMVAQGLVXPVFSFYL 812
+ FD++V Q + VFS +
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFSMQM 232
>AF200192-1|AAF13714.1| 518|Homo sapiens memapsin 1 protein.
Length = 518
Score = 70.5 bits (165), Expect = 7e-12
Identities = 46/147 (31%), Positives = 75/147 (51%), Gaps = 4/147 (2%)
Frame = +3
Query: 384 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQF 563
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S++Y + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 564 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 737
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 738 --VDHVTPVFDNMVAQGLVXPVFSFYL 812
+ FD++V Q + VFS +
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFSMQM 232
>AF188277-1|AAF35836.1| 396|Homo sapiens aspartyl protease protein.
Length = 396
Score = 70.5 bits (165), Expect = 7e-12
Identities = 46/147 (31%), Positives = 75/147 (51%), Gaps = 4/147 (2%)
Frame = +3
Query: 384 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQF 563
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S++Y + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 564 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 737
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 738 --VDHVTPVFDNMVAQGLVXPVFSFYL 812
+ FD++V Q + VFS +
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFSMQM 232
>AF188276-1|AAF35835.1| 468|Homo sapiens aspartyl protease protein.
Length = 468
Score = 70.5 bits (165), Expect = 7e-12
Identities = 46/147 (31%), Positives = 75/147 (51%), Gaps = 4/147 (2%)
Frame = +3
Query: 384 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQF 563
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S++Y + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 564 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 737
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 738 --VDHVTPVFDNMVAQGLVXPVFSFYL 812
+ FD++V Q + VFS +
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFSMQM 232
>AF178532-1|AAF29494.1| 518|Homo sapiens aspartyl protease protein.
Length = 518
Score = 70.5 bits (165), Expect = 7e-12
Identities = 46/147 (31%), Positives = 75/147 (51%), Gaps = 4/147 (2%)
Frame = +3
Query: 384 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQF 563
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S++Y + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 564 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 737
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 738 --VDHVTPVFDNMVAQGLVXPVFSFYL 812
+ FD++V Q + VFS +
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFSMQM 232
>AF117892-1|AAD45240.1| 518|Homo sapiens aspartic-like protease
protein.
Length = 518
Score = 70.5 bits (165), Expect = 7e-12
Identities = 46/147 (31%), Positives = 75/147 (51%), Gaps = 4/147 (2%)
Frame = +3
Query: 384 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQF 563
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S++Y + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 564 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 737
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 738 --VDHVTPVFDNMVAQGLVXPVFSFYL 812
+ FD++V Q + VFS +
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFSMQM 232
>AF050171-1|AAD45963.1| 518|Homo sapiens aspartyl protease protein.
Length = 518
Score = 70.5 bits (165), Expect = 7e-12
Identities = 46/147 (31%), Positives = 75/147 (51%), Gaps = 4/147 (2%)
Frame = +3
Query: 384 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQF 563
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S++Y + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 564 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 737
++Y GS +GF+ D VT+ G + E F+ K++GILG+A++T+A
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 738 --VDHVTPVFDNMVAQGLVXPVFSFYL 812
+ FD++V Q + VFS +
Sbjct: 206 KPSSSLETFFDSLVTQANIPNVFSMQM 232
>AK075539-1|BAC11682.1| 423|Homo sapiens protein ( Homo sapiens
cDNA PSEC0239 fis, clone OVARC1000363, highly similar to
Homo sapiens aspartyl protease mRNA. ).
Length = 423
Score = 69.3 bits (162), Expect = 2e-11
Identities = 44/141 (31%), Positives = 73/141 (51%), Gaps = 4/141 (2%)
Frame = +3
Query: 402 IGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQFAIQYGS 581
IGTPPQ +++ DTGSSN V Y + +D+ +S++Y + G ++Y
Sbjct: 3 IGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDVTVKYTQ 56
Query: 582 GSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA--VDHV 749
GS +GF+ D VT+ G + E G F+ +++GILG+A++T+A +
Sbjct: 57 GSWTGFVGEDLVTIPKGFNTSFLVNIATIFESGNFFLPGIQWNGILGLAYATLAKPSSSL 116
Query: 750 TPVFDNMVAQGLVXPVFSFYL 812
FD++V Q + VFS +
Sbjct: 117 ETFFDSLVTQANIPNVFSMQM 137
>DQ007053-1|AAY16982.1| 501|Homo sapiens beta-site APP-cleaving
enzyme 1 protein.
Length = 501
Score = 66.1 bits (154), Expect = 1e-10
Identities = 47/147 (31%), Positives = 76/147 (51%), Gaps = 4/147 (2%)
Frame = +3
Query: 384 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQF 563
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S++Y
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 564 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 737
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 738 --VDHVTPVFDNMVAQGLVXPVFSFYL 812
D + P FD++V Q V +FS L
Sbjct: 189 RPDDSLEPFFDSLVKQTHVPNLFSLQL 215
>BC065492-1|AAH65492.1| 501|Homo sapiens beta-site APP-cleaving
enzyme 1 protein.
Length = 501
Score = 66.1 bits (154), Expect = 1e-10
Identities = 47/147 (31%), Positives = 76/147 (51%), Gaps = 4/147 (2%)
Frame = +3
Query: 384 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQF 563
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S++Y
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 564 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 737
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 738 --VDHVTPVFDNMVAQGLVXPVFSFYL 812
D + P FD++V Q V +FS L
Sbjct: 189 RPDDSLEPFFDSLVKQTHVPNLFSLQL 215
>AF204943-1|AAF26367.1| 501|Homo sapiens transmembrane aspartic
proteinase Asp 2 protein.
Length = 501
Score = 66.1 bits (154), Expect = 1e-10
Identities = 47/147 (31%), Positives = 76/147 (51%), Gaps = 4/147 (2%)
Frame = +3
Query: 384 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQF 563
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S++Y
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 564 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 737
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 738 --VDHVTPVFDNMVAQGLVXPVFSFYL 812
D + P FD++V Q V +FS L
Sbjct: 189 RPDDSLEPFFDSLVKQTHVPNLFSLQL 215
>AF201468-1|AAF18982.1| 501|Homo sapiens APP beta-secretase
protein.
Length = 501
Score = 66.1 bits (154), Expect = 1e-10
Identities = 47/147 (31%), Positives = 76/147 (51%), Gaps = 4/147 (2%)
Frame = +3
Query: 384 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQF 563
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S++Y
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 564 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 737
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 738 --VDHVTPVFDNMVAQGLVXPVFSFYL 812
D + P FD++V Q V +FS L
Sbjct: 189 RPDDSLEPFFDSLVKQTHVPNLFSLQL 215
>AF200343-1|AAF17079.1| 501|Homo sapiens aspartyl protease 2
protein.
Length = 501
Score = 66.1 bits (154), Expect = 1e-10
Identities = 47/147 (31%), Positives = 76/147 (51%), Gaps = 4/147 (2%)
Frame = +3
Query: 384 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQF 563
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S++Y
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 564 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 737
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 738 --VDHVTPVFDNMVAQGLVXPVFSFYL 812
D + P FD++V Q V +FS L
Sbjct: 189 RPDDSLEPFFDSLVKQTHVPNLFSLQL 215
>AF200193-1|AAF13715.1| 488|Homo sapiens memapsin 2 protein.
Length = 488
Score = 66.1 bits (154), Expect = 1e-10
Identities = 47/147 (31%), Positives = 76/147 (51%), Gaps = 4/147 (2%)
Frame = +3
Query: 384 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQF 563
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S++Y
Sbjct: 62 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 115
Query: 564 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 737
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 116 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 175
Query: 738 --VDHVTPVFDNMVAQGLVXPVFSFYL 812
D + P FD++V Q V +FS L
Sbjct: 176 RPDDSLEPFFDSLVKQTHVPNLFSLQL 202
>AF190725-1|AAF04142.1| 501|Homo sapiens beta-site APP cleaving
enzyme protein.
Length = 501
Score = 66.1 bits (154), Expect = 1e-10
Identities = 47/147 (31%), Positives = 76/147 (51%), Gaps = 4/147 (2%)
Frame = +3
Query: 384 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQF 563
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S++Y
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 564 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 737
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 738 --VDHVTPVFDNMVAQGLVXPVFSFYL 812
D + P FD++V Q V +FS L
Sbjct: 189 RPDDSLEPFFDSLVKQTHVPNLFSLQL 215
>AB032975-1|BAA86463.2| 532|Homo sapiens KIAA1149 protein protein.
Length = 532
Score = 66.1 bits (154), Expect = 1e-10
Identities = 47/147 (31%), Positives = 76/147 (51%), Gaps = 4/147 (2%)
Frame = +3
Query: 384 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQF 563
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S++Y
Sbjct: 106 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 159
Query: 564 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 737
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 160 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 219
Query: 738 --VDHVTPVFDNMVAQGLVXPVFSFYL 812
D + P FD++V Q V +FS L
Sbjct: 220 RPDDSLEPFFDSLVKQTHVPNLFSLQL 246
>BC036084-1|AAH36084.1| 501|Homo sapiens beta-site APP-cleaving
enzyme 1 protein.
Length = 501
Score = 63.7 bits (148), Expect = 8e-10
Identities = 46/147 (31%), Positives = 75/147 (51%), Gaps = 4/147 (2%)
Frame = +3
Query: 384 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQF 563
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + ++Y
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLFSTYRDLRKGV 128
Query: 564 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 737
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 738 --VDHVTPVFDNMVAQGLVXPVFSFYL 812
D + P FD++V Q V +FS L
Sbjct: 189 RPDDSLEPFFDSLVKQTHVPNLFSLQL 215
>AL365205-2|CAI95135.1| 140|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 140
Score = 61.7 bits (143), Expect = 3e-09
Identities = 30/70 (42%), Positives = 42/70 (60%), Gaps = 1/70 (1%)
Frame = +3
Query: 621 VGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPVFDNMVAQG-LVXPV 797
V ++V Q F + +EPG FV A+FDGI+G+A+ ++VD T MV +G L PV
Sbjct: 71 VQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPV 130
Query: 798 FSFYLNRDPG 827
FS YL+ G
Sbjct: 131 FSVYLSNQQG 140
>BC042578-1|AAH42578.1| 104|Homo sapiens PGC protein protein.
Length = 104
Score = 60.1 bits (139), Expect = 1e-08
Identities = 38/82 (46%), Positives = 49/82 (59%), Gaps = 9/82 (10%)
Frame = +3
Query: 240 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 392
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 393 VISIGTPPQSFKVVFDTGSSNL 458
ISIGTPPQ+F V+FDTGSS L
Sbjct: 76 EISIGTPPQNFLVLFDTGSSPL 97
>AF338816-1|AAK38374.1| 476|Homo sapiens beta-site APP cleaving
enzyme type B protein.
Length = 476
Score = 55.2 bits (127), Expect = 3e-07
Identities = 37/120 (30%), Positives = 62/120 (51%), Gaps = 2/120 (1%)
Frame = +3
Query: 384 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQF 563
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S++Y
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 564 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 737
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
>AB050436-1|BAB40931.1| 476|Homo sapiens beta-site APP cleaving
enzyme I-476 protein.
Length = 476
Score = 55.2 bits (127), Expect = 3e-07
Identities = 37/120 (30%), Positives = 62/120 (51%), Gaps = 2/120 (1%)
Frame = +3
Query: 384 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQF 563
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S++Y
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 564 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA 737
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
>AL163285-1|CAB90554.1| 415|Homo sapiens beta-site APP-cleaving
enzyme 2, EC 3.4.23. protein.
Length = 415
Score = 54.0 bits (124), Expect = 6e-07
Identities = 38/133 (28%), Positives = 66/133 (49%), Gaps = 4/133 (3%)
Frame = +3
Query: 426 KVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQFAIQYGSGSLSGFLS 605
+++ DTGSSN V Y + +D+ +S++Y + G ++Y GS +GF+
Sbjct: 3 QILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVG 56
Query: 606 TDDVTV-GGLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA--VDHVTPVFDNMV 773
D VT+ G + E F+ K++GILG+A++T+A + FD++V
Sbjct: 57 EDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLV 116
Query: 774 AQGLVXPVFSFYL 812
Q + VFS +
Sbjct: 117 TQANIPNVFSMQM 129
>AB177847-1|BAD66825.1| 396|Homo sapiens KIAA1149 splice variant 1
protein.
Length = 396
Score = 41.1 bits (92), Expect = 0.005
Identities = 29/86 (33%), Positives = 46/86 (53%), Gaps = 4/86 (4%)
Frame = +3
Query: 567 IQYGSGSLSGFLSTDDVTVG-GLKVRRQTFAEAVSEPGLAFV-AAKFDGILGMAFSTIA- 737
+ Y G G L TD V++ G V + A++E F+ + ++GILG+A++ IA
Sbjct: 25 VPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIAR 84
Query: 738 -VDHVTPVFDNMVAQGLVXPVFSFYL 812
D + P FD++V Q V +FS L
Sbjct: 85 PDDSLEPFFDSLVKQTHVPNLFSLQL 110
>AB050438-1|BAB40933.1| 432|Homo sapiens beta-site APP cleaving
enzyme I-432 protein.
Length = 432
Score = 41.1 bits (92), Expect = 0.005
Identities = 26/94 (27%), Positives = 43/94 (45%)
Frame = +3
Query: 384 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQF 563
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S++Y
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 564 AIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAV 665
+ Y G G L TD + G + + +V
Sbjct: 129 YVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASV 162
>AF338817-1|AAK38375.1| 457|Homo sapiens beta-site APP cleaving
enzyme type C protein.
Length = 457
Score = 40.7 bits (91), Expect = 0.006
Identities = 24/76 (31%), Positives = 37/76 (48%)
Frame = +3
Query: 384 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQF 563
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S++Y
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 564 AIQYGSGSLSGFLSTD 611
+ Y G G L TD
Sbjct: 129 YVPYTQGKWEGELGTD 144
>AB050437-1|BAB40932.1| 457|Homo sapiens beta-site APP cleaving
enzyme I-457 protein.
Length = 457
Score = 40.7 bits (91), Expect = 0.006
Identities = 24/76 (31%), Positives = 37/76 (48%)
Frame = +3
Query: 384 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQF 563
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S++Y
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 564 AIQYGSGSLSGFLSTD 611
+ Y G G L TD
Sbjct: 129 YVPYTQGKWEGELGTD 144
>AL365205-3|CAM16152.1| 86|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 86
Score = 38.7 bits (86), Expect = 0.026
Identities = 28/70 (40%), Positives = 37/70 (52%), Gaps = 9/70 (12%)
Frame = +3
Query: 231 SVMALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQ 383
+V+ RVPL + K+ R E G E LR KYD + EP++ Y+DA
Sbjct: 18 AVICKQRVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAA 76
Query: 384 YYGVISIGTP 413
Y+G ISIGTP
Sbjct: 77 YFGEISIGTP 86
>AB089958-1|BAC81826.1| 127|Homo sapiens beta-site APP cleaving
enzyme isoform I-127 protein.
Length = 127
Score = 35.5 bits (78), Expect = 0.24
Identities = 18/53 (33%), Positives = 30/53 (56%)
Frame = +3
Query: 384 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSY 542
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S++Y
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTY 121
>BC104851-1|AAI04852.1| 147|Homo sapiens LOC283174 protein protein.
Length = 147
Score = 31.1 bits (67), Expect = 5.2
Identities = 20/75 (26%), Positives = 32/75 (42%)
Frame = +3
Query: 441 TGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQFAIQYGSGSLSGFLSTDDVT 620
T + LW + + C L N S+ TS++ G+ Q S S FL+ ++
Sbjct: 7 THNGRLWGAGVHLYLSRKQCALKNTSLSKFQTSHICKGSALQPQQASPGASSFLTCPELG 66
Query: 621 VGGLKVRRQTFAEAV 665
V LK+ +AV
Sbjct: 67 VMYLKLVLGQMVQAV 81
>BC101691-1|AAI01692.1| 147|Homo sapiens LOC283174 protein protein.
Length = 147
Score = 31.1 bits (67), Expect = 5.2
Identities = 20/75 (26%), Positives = 32/75 (42%)
Frame = +3
Query: 441 TGSSNLWVPSKKCHYTNIACLLHNKYDSRKSTSYVANGTQFAIQYGSGSLSGFLSTDDVT 620
T + LW + + C L N S+ TS++ G+ Q S S FL+ ++
Sbjct: 7 THNGRLWGAGVHLYLSRKQCALKNTSLSKFQTSHICKGSALQPQQASPGASSFLTCPELG 66
Query: 621 VGGLKVRRQTFAEAV 665
V LK+ +AV
Sbjct: 67 VMYLKLVLGQMVQAV 81
>BC030606-1|AAH30606.2| 514|Homo sapiens coiled-coil domain
containing 11 protein.
Length = 514
Score = 30.7 bits (66), Expect = 6.9
Identities = 12/26 (46%), Positives = 18/26 (69%)
Frame = -2
Query: 449 GSGVEYHLERLRRRADTDHSVVLSIK 372
G G E+HLER+RR ++++ SIK
Sbjct: 30 GQGAEHHLERIRRSHQKHNAILASIK 55
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 118,735,605
Number of Sequences: 237096
Number of extensions: 2539537
Number of successful extensions: 6673
Number of sequences better than 10.0: 74
Number of HSP's better than 10.0 without gapping: 6053
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6563
length of database: 76,859,062
effective HSP length: 89
effective length of database: 55,757,518
effective search space used: 10593928420
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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