Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fcaL-P04_F_B05
(828 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
BC067430-1|AAH67430.1| 491|Homo sapiens cytochrome P450, family... 109 9e-24
AK223113-1|BAD96833.1| 512|Homo sapiens cytochrome P450, family... 109 1e-23
X04300-1|CAA27843.1| 512|Homo sapiens P-450 c protein. 109 2e-23
X02612-1|CAA26458.1| 512|Homo sapiens cytochrome P(1)-450 protein. 109 2e-23
EF094025-1|ABK41999.1| 512|Homo sapiens cytochrome P450, family... 109 2e-23
BC023019-1|AAH23019.1| 512|Homo sapiens cytochrome P450, family... 109 2e-23
AF253322-1|AAK25727.1| 512|Homo sapiens cytochrome P450 protein. 109 2e-23
K03191-1|AAA52139.1| 512|Homo sapiens CYP1A1 protein. 108 2e-23
AY871801-1|AAX62803.1| 483|Homo sapiens cytochrome P450 family ... 108 2e-23
M29874-1|AAA52144.1| 491|Homo sapiens CYP2B protein. 107 4e-23
DQ298753-1|ABB84469.1| 491|Homo sapiens cytochrome P450, family... 107 4e-23
AF182277-1|AAF13602.1| 491|Homo sapiens cytochrome P450-2B6 pro... 107 4e-23
AC023172-1|AAF32444.1| 491|Homo sapiens CYP2B6 protein. 107 4e-23
M29873-1|AAA52143.1| 377|Homo sapiens CYP2B protein. 106 8e-23
BC067431-1|AAH67431.1| 491|Homo sapiens cytochrome P450, family... 106 8e-23
BC041174-1|AAH41174.1| 377|Homo sapiens CYP2B7P1 protein protein. 106 8e-23
AK223108-1|BAD96828.1| 512|Homo sapiens cytochrome P450, family... 106 8e-23
U37143-1|AAC50370.2| 502|Homo sapiens cytochrome P450 monooxyge... 105 3e-22
EF122242-1|ABO41977.1| 321|Homo sapiens cytochrome P450 2F1 var... 105 3e-22
BC032594-1|AAH32594.1| 502|Homo sapiens cytochrome P450, family... 105 3e-22
AY426985-1|AAQ93356.1| 502|Homo sapiens cytochrome P450, family... 105 3e-22
AF272142-1|AAM44456.1| 502|Homo sapiens cytochrome P450 protein. 105 3e-22
AB080265-1|BAB85489.1| 502|Homo sapiens cytochrome P450 2J2 pro... 105 3e-22
AF144566-1|AAD30164.1| 339|Homo sapiens cytochrome P450 epoxyge... 104 3e-22
AY220845-1|AAO49806.1| 516|Homo sapiens cytochrome P450 protein. 103 8e-22
M21941-1|AAA52160.1| 480|Homo sapiens CYP2C protein. 102 2e-21
EF122241-1|ABO41976.1| 491|Homo sapiens cytochrome P450 2F1 var... 101 2e-21
Y00498-1|CAA68550.1| 490|Homo sapiens IIC2 protein. 101 3e-21
AY514490-1|AAR89907.1| 490|Homo sapiens cytochrome P450, family... 101 3e-21
AL359672-5|CAH71307.1| 490|Homo sapiens cytochrome P450, family... 101 3e-21
BC020596-1|AAH20596.1| 490|Homo sapiens cytochrome P450, family... 101 4e-21
M17398-1|AAA35740.1| 393|Homo sapiens protein ( Human cytochrom... 100 7e-21
M17397-1|AAA35739.1| 490|Homo sapiens protein ( Human cytochrom... 100 7e-21
BC109056-1|AAI09057.1| 320|Homo sapiens CYP2F1 protein protein. 99 1e-20
M21942-1|AAA52161.1| 462|Homo sapiens CYP2C protein. 100 1e-20
S46963-1|AAB23864.2| 477|Homo sapiens cytochrome P-450 protein. 98 3e-20
M21939-1|AAA52158.1| 485|Homo sapiens CYP2C protein. 98 3e-20
M15331-1|AAA52157.1| 485|Homo sapiens CYP2C protein. 98 3e-20
L16880-1|AAD13466.1| 273|Homo sapiens cytochrome P-450 2C protein. 98 3e-20
D00173-1|BAA00123.1| 487|Homo sapiens cytochrome P-450 protein. 98 3e-20
BC125054-1|AAI25055.1| 490|Homo sapiens cytochrome P450, family... 98 3e-20
AY702706-1|AAT94065.1| 490|Homo sapiens cytochrome P450, family... 98 3e-20
AY341248-1|AAP88931.1| 490|Homo sapiens cytochrome P450, family... 98 3e-20
AL359672-1|CAH71303.1| 490|Homo sapiens cytochrome P450, family... 98 3e-20
DQ282158-1|ABB77906.1| 497|Homo sapiens cytochrome P450 2D6 pro... 97 9e-20
DQ282157-1|ABB77905.1| 497|Homo sapiens cytochrome P450 2D6 pro... 97 9e-20
DQ282153-1|ABB77901.1| 497|Homo sapiens cytochrome P450 2D6 pro... 97 9e-20
X08006-1|CAA30807.1| 497|Homo sapiens cytochrome P450 db1 protein. 96 1e-19
M61856-1|AAB59356.1| 490|Homo sapiens cytochrome protein. 96 1e-19
M33388-1|AAA53500.1| 497|Homo sapiens cytochrome P450 IID6 prot... 96 1e-19
M20403-1|AAA52153.1| 497|Homo sapiens CYP2D protein. 96 1e-19
L16876-1|AAA02630.1| 490|Homo sapiens cytochrome P-4502C18 prot... 96 1e-19
DQ282160-1|ABB77908.1| 497|Homo sapiens cytochrome P450 2D6 pro... 96 1e-19
DQ282159-1|ABB77907.1| 497|Homo sapiens cytochrome P450 2D6 pro... 96 1e-19
DQ282156-1|ABB77904.1| 497|Homo sapiens cytochrome P450 2D6 pro... 96 1e-19
DQ282151-1|ABB77899.1| 496|Homo sapiens cytochrome P450 2D6 pro... 96 1e-19
DQ282147-1|ABB77898.1| 497|Homo sapiens cytochrome P450 2D6 pro... 96 1e-19
DQ282146-1|ABB77897.1| 497|Homo sapiens cytochrome P450 2D6 pro... 96 1e-19
DQ282145-1|ABB77896.1| 497|Homo sapiens cytochrome P450 2D6 pro... 96 1e-19
DQ282144-1|ABB77895.1| 497|Homo sapiens cytochrome P450 2D6 pro... 96 1e-19
BC126858-1|AAI26859.1| 497|Homo sapiens cytochrome P450, family... 96 1e-19
BC106758-1|AAI06759.1| 497|Homo sapiens cytochrome P450, family... 96 1e-19
BC096259-1|AAH96259.1| 443|Homo sapiens CYP2C18 protein protein. 96 1e-19
BC096258-1|AAH96258.1| 490|Homo sapiens cytochrome P450, family... 96 1e-19
BC096257-1|AAH96257.1| 490|Homo sapiens cytochrome P450, family... 96 1e-19
BC075024-1|AAH75024.1| 497|Homo sapiens cytochrome P450, family... 96 1e-19
BC075023-1|AAH75023.1| 497|Homo sapiens cytochrome P450, family... 96 1e-19
BC069666-1|AAH69666.1| 490|Homo sapiens cytochrome P450, family... 96 1e-19
BC067432-1|AAH67432.1| 497|Homo sapiens cytochrome P450, family... 96 1e-19
AY545216-1|AAS55001.1| 497|Homo sapiens cytochrome P4502D6 prot... 96 1e-19
AL583836-1|CAH74067.1| 490|Homo sapiens cytochrome P450, family... 96 1e-19
DQ282154-1|ABB77902.1| 497|Homo sapiens cytochrome P450 2D6 pro... 96 2e-19
M61854-1|AAB59426.1| 490|Homo sapiens cytochrome protein. 95 2e-19
AY796203-1|AAV41877.1| 490|Homo sapiens cytochrome P450, family... 95 2e-19
AL583836-2|CAH74068.1| 490|Homo sapiens cytochrome P450, family... 95 2e-19
AL133513-2|CAH73444.1| 490|Homo sapiens cytochrome P450, family... 95 2e-19
X13930-1|CAA32118.1| 494|Homo sapiens protein ( Human CYP2A4 mR... 95 3e-19
BC096255-1|AAH96255.1| 494|Homo sapiens cytochrome P450, family... 95 3e-19
AK223510-1|BAD97230.1| 490|Homo sapiens cytochrome P450, family... 95 3e-19
AF372573-1|AAL69652.1| 495|Homo sapiens cytochrome P450 2F1 pro... 95 3e-19
DQ282155-1|ABB77903.1| 497|Homo sapiens cytochrome P450 2D6 pro... 95 4e-19
X13897-1|CAA32097.1| 489|Homo sapiens protein ( Human mRNA for ... 94 5e-19
M33318-1|AAA52067.1| 494|Homo sapiens CYP2A protein. 94 5e-19
M33317-1|AAA52138.1| 494|Homo sapiens CYP2A protein. 94 5e-19
BC096256-1|AAH96256.1| 494|Homo sapiens cytochrome P450, family... 94 5e-19
BC096254-1|AAH96254.1| 494|Homo sapiens cytochrome P450, family... 94 5e-19
BC096253-1|AAH96253.3| 494|Homo sapiens cytochrome P450, family... 94 5e-19
AF182275-1|AAF13600.1| 494|Homo sapiens cytochrome P450-2A6 pro... 94 5e-19
AY513608-1|AAR90939.1| 494|Homo sapiens cytochrome P450 2A13 va... 93 8e-19
U22028-1|AAB40519.1| 494|Homo sapiens cytochrome P450 protein. 93 1e-18
DQ282152-1|ABB77900.1| 497|Homo sapiens cytochrome P450 2D6 pro... 93 1e-18
DQ211354-2|ABB01372.1| 497|Homo sapiens cytochrome P450 2D6 pro... 93 1e-18
DQ211353-2|ABB01371.1| 497|Homo sapiens cytochrome P450 2D6 pro... 93 1e-18
DQ211353-1|ABB01370.1| 497|Homo sapiens cytochrome P450 2D6 pro... 93 1e-18
J02906-1|AAA52156.1| 491|Homo sapiens CYP2F1 protein. 93 1e-18
AY513609-1|AAR90940.1| 494|Homo sapiens cytochrome P450 2A13 va... 93 1e-18
AY513606-1|AAR90937.1| 494|Homo sapiens cytochrome P450 2A13 va... 93 1e-18
AY513605-1|AAR90936.1| 494|Homo sapiens cytochrome P450 2A13 va... 93 1e-18
AY513604-1|AAR90935.1| 494|Homo sapiens cytochrome P450 2A13 va... 93 1e-18
AF209774-1|AAG35775.1| 494|Homo sapiens cytochrome P450 2A13 pr... 93 1e-18
AF182276-1|AAF13601.1| 493|Homo sapiens cytochrome P450-2E1 pro... 93 1e-18
U22029-1|AAB40520.1| 494|Homo sapiens cytochrome P450 protein. 92 2e-18
J02843-1|AAA52155.1| 493|Homo sapiens protein ( Human cytochrom... 92 2e-18
J02625-1|AAA35743.1| 493|Homo sapiens protein ( Human cytochrom... 92 2e-18
DQ515958-1|ABF47105.1| 493|Homo sapiens cytochrome P450, family... 92 2e-18
DQ149222-1|AAZ77710.1| 493|Homo sapiens cytochrome P450 2E1 pro... 92 2e-18
BC117165-1|AAI17166.1| 494|Homo sapiens cytochrome P450, family... 92 2e-18
AL161645-2|CAH70047.1| 493|Homo sapiens cytochrome P450, family... 92 2e-18
U22027-1|AAB40518.1| 494|Homo sapiens cytochrome P450 protein. 92 3e-18
BC067433-1|AAH67433.1| 493|Homo sapiens cytochrome P450, family... 92 3e-18
AF084225-1|AAD13753.1| 462|Homo sapiens cytochrome P450 2E1 pro... 92 3e-18
DQ282162-1|ABB77909.1| 500|Homo sapiens cytochrome P450 2D6 pro... 91 6e-18
BC132767-1|AAI32768.1| 544|Homo sapiens cytochrome P450, family... 91 6e-18
AY343323-1|AAQ21380.1| 544|Homo sapiens cytochrome P450 protein. 91 6e-18
AY310359-1|AAQ76692.1| 484|Homo sapiens cytochrome P450 1A1 var... 91 6e-18
BC067435-1|AAH67435.1| 493|Homo sapiens cytochrome P450, family... 90 8e-18
AM236046-1|CAJ84703.1| 229|Homo sapiens cytochrome P450 1A1 pro... 89 2e-17
BC096260-1|AAH96260.1| 431|Homo sapiens CYP2C18 protein protein. 84 5e-16
Z00036-1|CAA77335.1| 515|Homo sapiens protein ( Human mRNA for ... 83 2e-15
M55053-1|AAA52146.1| 515|Homo sapiens cytochrome P3-450 protein. 83 2e-15
M31667-1|AAA52163.1| 515|Homo sapiens CYP1A2 protein. 83 2e-15
DQ022432-1|AAY26399.1| 516|Homo sapiens cytochrome P450, family... 83 2e-15
BC067429-1|AAH67429.1| 516|Homo sapiens cytochrome P450, family... 83 2e-15
BC067428-1|AAH67428.1| 516|Homo sapiens cytochrome P450, family... 83 2e-15
BC067426-1|AAH67426.1| 516|Homo sapiens cytochrome P450, family... 83 2e-15
BC067425-1|AAH67425.1| 516|Homo sapiens cytochrome P450, family... 83 2e-15
BC067424-1|AAH67424.1| 516|Homo sapiens cytochrome P450, family... 83 2e-15
AF253322-2|AAK25728.1| 516|Homo sapiens cytochrome P450 protein. 83 2e-15
AF182274-1|AAF13599.1| 516|Homo sapiens cytochrome P450-1A2 pro... 81 4e-15
L00389-1|AAA35738.1| 516|Homo sapiens protein ( Human cytochrom... 80 8e-15
BC067427-1|AAH67427.1| 516|Homo sapiens cytochrome P450, family... 80 1e-14
S63426-1|ABB76283.1| 214|Homo sapiens (S)-mephenytoin hydroxyla... 79 2e-14
AM233520-1|CAJ80723.1| 189|Homo sapiens cytochrome P450 1A1 pro... 79 3e-14
AM233519-1|CAJ80722.1| 189|Homo sapiens cytochrome P450 1A1 pro... 79 3e-14
X13929-1|CAA32117.1| 448|Homo sapiens P-450 IIA3 protein (1 is ... 77 6e-14
L07093-1|AAA36660.1| 468|Homo sapiens cytochrome P450 protein. 77 6e-14
BC070317-1|AAH70317.1| 162|Homo sapiens CYP2C9 protein protein. 77 6e-14
BC020754-1|AAH20754.1| 162|Homo sapiens CYP2C9 protein protein. 77 6e-14
L39098-1|AAL31347.1| 160|Homo sapiens S-mephenytoin 4-hydroxyla... 77 8e-14
BC104909-1|AAI04910.1| 501|Homo sapiens cytochrome P450, family... 76 1e-13
BC104907-1|AAI04908.1| 501|Homo sapiens cytochrome P450, family... 76 1e-13
AY323817-1|AAQ23114.1| 501|Homo sapiens cytochrome P450 2R1 pro... 76 1e-13
AB209492-1|BAD92729.1| 566|Homo sapiens Debrisoquine 4-hydroxyl... 63 9e-13
BC033691-1|AAH33691.1| 504|Homo sapiens cytochrome P450, family... 73 1e-12
AY358603-1|AAQ88966.1| 504|Homo sapiens Cytochrome p450 protein. 73 1e-12
AK027605-1|BAB55227.1| 564|Homo sapiens protein ( Homo sapiens ... 73 1e-12
AF335278-1|AAK13498.1| 504|Homo sapiens cytochrome P450 2S1 pro... 73 1e-12
BC025761-1|AAH25761.2| 490|Homo sapiens cytochrome P450, family... 69 2e-11
U56438-1|AAC50809.1| 543|Homo sapiens dioxin-inducible cytochro... 64 8e-10
U03688-1|AAA19567.1| 543|Homo sapiens cytochrome P450 protein. 64 8e-10
BT019979-1|AAV38782.1| 543|Homo sapiens cytochrome P450, family... 64 8e-10
BC012049-1|AAH12049.1| 543|Homo sapiens cytochrome P450, family... 64 8e-10
AY393998-1|AAQ87875.1| 543|Homo sapiens cytochrome P450, family... 64 8e-10
AF450132-1|AAM50512.1| 543|Homo sapiens cytochrome P450 CYP1B1 ... 64 8e-10
AC009229-2|AAY15039.1| 543|Homo sapiens unknown protein. 64 8e-10
M21940-1|AAA52159.1| 383|Homo sapiens CYP2C protein. 63 1e-09
DQ359216-1|ABC95161.1| 347|Homo sapiens dioxin-inducible cytoch... 63 1e-09
BT020001-1|AAV38804.1| 543|Homo sapiens cytochrome P450, family... 63 1e-09
M33189-1|AAA35737.1| 500|Homo sapiens protein ( Human debrisoqu... 62 2e-09
M24499-1|AAA36403.1| 373|Homo sapiens cytochrome P450db1 protein. 61 5e-09
AK000366-1|BAA91114.1| 408|Homo sapiens protein ( Homo sapiens ... 52 2e-06
M63871-1|AAA59984.1| 508|Homo sapiens CYP17 protein. 51 6e-06
M19489-1|AAA36405.1| 508|Homo sapiens CYP17 protein. 51 6e-06
M14564-1|AAA52151.1| 508|Homo sapiens CYP17 protein. 50 8e-06
DQ530598-1|ABF50972.1| 508|Homo sapiens cytochrome P450, family... 50 8e-06
BT020000-1|AAV38803.1| 508|Homo sapiens cytochrome P450, family... 50 8e-06
BC063388-1|AAH63388.1| 508|Homo sapiens cytochrome P450, family... 50 8e-06
BC062997-1|AAH62997.1| 508|Homo sapiens cytochrome P450, family... 50 8e-06
AL358790-3|CAI52498.1| 508|Homo sapiens cytochrome P450, family... 50 8e-06
M31153-1|AAA52140.1| 508|Homo sapiens CYP17 protein. 50 1e-05
M61858-1|AAA52145.1| 370|Homo sapiens CYP2C17 protein. 48 4e-05
BC109084-1|AAI09085.1| 448|Homo sapiens CYP24A1 protein protein. 47 1e-04
BC109083-1|AAI09084.1| 448|Homo sapiens CYP24A1 protein protein. 47 1e-04
AL138805-3|CAM27343.1| 448|Homo sapiens cytochrome P450, family... 47 1e-04
AL138805-2|CAB91829.1| 514|Homo sapiens cytochrome P450, family... 47 1e-04
L13286-1|AAA62379.1| 513|Homo sapiens 1,25-dihydroxyvitamin D3 ... 46 1e-04
CR456430-1|CAG30316.1| 446|Homo sapiens CYP2D6 protein. 46 2e-04
BC106757-1|AAI06758.1| 446|Homo sapiens cytochrome P450, family... 46 2e-04
BC066877-1|AAH66877.1| 446|Homo sapiens CYP2D6 protein protein. 46 2e-04
AY513607-1|AAR90938.1| 100|Homo sapiens truncated cytochrome P4... 45 3e-04
J04813-1|AAA02993.1| 502|Homo sapiens cytochrome P450 PCN3 prot... 45 4e-04
DQ680079-1|ABG25922.1| 347|Homo sapiens truncated cytochrome P4... 45 4e-04
BC033862-1|AAH33862.1| 502|Homo sapiens cytochrome P450, family... 45 4e-04
AC005020-1|AAS02016.1| 502|Homo sapiens unknown protein. 45 4e-04
AK223008-1|BAD96728.1| 502|Homo sapiens cytochrome P450, family... 44 5e-04
DQ211355-2|ABB01373.1| 117|Homo sapiens cytochrome P450 2D6 pro... 42 0.002
J04449-1|AAA35747.1| 502|Homo sapiens cytochrome P450 nifedipin... 42 0.004
DQ372705-1|ABD16216.1| 150|Homo sapiens mutant cytochrome p450 ... 42 0.004
AF280107-4|AAG32288.1| 106|Homo sapiens cytochrome P450 polypep... 42 0.004
X12387-1|CAA30944.1| 503|Homo sapiens protein ( Human mRNA for ... 41 0.005
M18907-1|AAA35745.1| 503|Homo sapiens protein ( Human P450 mRNA... 41 0.005
M14096-1|AAA35744.1| 503|Homo sapiens protein ( Human cytochrom... 41 0.005
DQ924960-1|ABI96208.1| 503|Homo sapiens cytochrome P450 family ... 41 0.005
DQ005611-1|AAY16980.1| 503|Homo sapiens cytochrome P450, family... 41 0.005
BC101631-1|AAI01632.1| 503|Homo sapiens cytochrome P450, subfam... 41 0.005
BC069418-1|AAH69418.1| 503|Homo sapiens cytochrome P450, family... 41 0.005
AJ563375-1|CAD91343.1| 503|Homo sapiens cytochrome P450 protein. 41 0.005
AF280107-2|AAG32290.1| 503|Homo sapiens cytochrome P450 polypep... 41 0.005
AF209389-1|AAF21034.1| 503|Homo sapiens cytochrome P450 IIIA4 p... 41 0.005
AF182273-1|AAF13598.1| 503|Homo sapiens cytochrome P450-3A4 pro... 41 0.005
AF171066-1|AAG43404.1| 112|Homo sapiens CYP1B1 variant protein. 39 0.019
X65962-1|CAA46778.1| 356|Homo sapiens cytochrome P-450 II C pro... 39 0.025
BC022539-1|AAH22539.1| 500|Homo sapiens cytochrome P450, family... 38 0.034
AF094480-1|AAD41244.1| 500|Homo sapiens cholesterol 24-hydroxyl... 38 0.034
BC012027-1|AAH12027.1| 168|Homo sapiens CYP2U1 protein protein. 38 0.044
AY390425-1|AAQ92353.1| 503|Homo sapiens cytochrome P450 CYP3A43... 38 0.059
AY390424-1|AAQ92352.1| 503|Homo sapiens cytochrome P450 CYP3A43... 38 0.059
AF337813-1|AAK38841.1| 503|Homo sapiens cytochrome P450 subfami... 38 0.059
AF319634-1|AAK00325.1| 503|Homo sapiens cytochrome P450 CYP3A43... 38 0.059
AF280111-1|AAG33012.1| 250|Homo sapiens cytochrome P450 subfami... 38 0.059
AF280110-1|AAG33011.1| 420|Homo sapiens cytochrome P450 subfami... 38 0.059
AF280109-1|AAG33010.1| 504|Homo sapiens cytochrome P450 subfami... 38 0.059
AF280108-1|AAG33009.1| 503|Homo sapiens cytochrome P450 subfami... 38 0.059
AC011904-5|AAS07394.1| 504|Homo sapiens unknown protein. 38 0.059
AC011904-4|AAS07395.1| 503|Homo sapiens unknown protein. 38 0.059
M13785-1|AAA35742.1| 504|Homo sapiens protein ( Human liver glu... 37 0.10
D00003-1|BAA00001.1| 504|Homo sapiens cytochrome P-450 protein. 37 0.10
X58906-1|CAA41709.1| 495|Homo sapiens steroid 21-monooxygenase ... 36 0.24
X58904-1|CAA41707.1| 371|Homo sapiens steroid 21-monooxygenase ... 36 0.24
X58902-1|CAA41706.1| 372|Homo sapiens steroid 21-monooxygenase ... 36 0.24
X58900-1|CAA41704.1| 372|Homo sapiens steroid 21-monooxygenase ... 36 0.24
X54807-1|CAA38578.1| 56|Homo sapiens unspecific monooxygenase ... 36 0.24
M28548-1|AAA52065.1| 495|Homo sapiens protein ( Human mutant 21... 36 0.24
M26856-1|AAA52064.1| 495|Homo sapiens protein ( Human 21-hydrox... 36 0.24
M21550-1|AAA52063.1| 495|Homo sapiens CYP21 protein. 36 0.24
M13936-1|AAA59695.1| 494|Homo sapiens CYP21P protein. 36 0.24
M12792-1|AAB59440.1| 494|Homo sapiens steroid 21-hydroxylase pr... 36 0.24
BX679671-8|CAM26070.1| 494|Homo sapiens cytochrome P450, family... 36 0.24
BC125182-1|AAI25183.1| 494|Homo sapiens cytochrome P450, family... 36 0.24
BC125181-1|AAI25182.1| 495|Homo sapiens cytochrome P450, family... 36 0.24
AM183951-1|CAJ75805.1| 494|Homo sapiens steroid 21-hydroxylase,... 36 0.24
AM183950-1|CAJ75804.1| 494|Homo sapiens steroid 21-hydroxylase,... 36 0.24
AM183949-1|CAJ75803.1| 494|Homo sapiens steroid 21-hydroxylase,... 36 0.24
AM183948-1|CAJ75802.1| 494|Homo sapiens steroid 21-hydroxylase ... 36 0.24
AM086565-1|CAJ31104.1| 494|Homo sapiens steroid 21-hydroxylase,... 36 0.24
AL929593-1|CAI41779.1| 495|Homo sapiens cytochrome P450, family... 36 0.24
AL662849-18|CAI17479.1| 495|Homo sapiens cytochrome P450, famil... 36 0.24
AL645922-24|CAI41754.1| 495|Homo sapiens cytochrome P450, famil... 36 0.24
AL049547-7|CAB89301.1| 495|Homo sapiens dJ34F7.3 (cytochrome P4... 36 0.24
AF280107-1|AAG32291.1| 106|Homo sapiens cytochrome P450 polypep... 36 0.24
AF019413-2|AAB67982.1| 495|Homo sapiens cytochrome P450 21-hydr... 36 0.24
AM183947-1|CAJ75801.1| 494|Homo sapiens steroid 21-hydroxylase,... 35 0.31
AB209700-1|BAD92937.1| 336|Homo sapiens cytochrome P450, family... 35 0.31
AM183946-1|CAJ75800.1| 494|Homo sapiens steroid 21-hydroxylase,... 35 0.41
BX538127-1|CAD98029.1| 310|Homo sapiens hypothetical protein pr... 34 0.55
AL512656-1|CAI15290.1| 488|Homo sapiens annexin A7 protein. 34 0.55
AL353731-3|CAI52484.1| 488|Homo sapiens annexin A7 protein. 34 0.55
AM183945-1|CAJ75799.1| 494|Homo sapiens steroid 21-hydroxylase,... 34 0.72
X58898-1|CAA41702.1| 371|Homo sapiens steroid 21-monooxygenase ... 33 0.95
AM086564-1|CAJ31103.1| 494|Homo sapiens steroid 21-hydroxylase,... 33 0.95
X56452-1|CAA39833.1| 56|Homo sapiens unspecific monooxygenase ... 31 3.9
AF081569-1|AAD25924.1| 52|Homo sapiens cytochrome P450 protein. 31 3.9
D00408-1|BAA00310.1| 503|Homo sapiens cytochrome P-450 HFLa pro... 31 6.7
BC067436-1|AAH67436.1| 503|Homo sapiens cytochrome P450, family... 31 6.7
AF315325-1|AAG48618.1| 535|Homo sapiens cytochrome P450 variant... 31 6.7
AF280107-3|AAG32289.1| 503|Homo sapiens cytochrome P450 polypep... 31 6.7
BC001964-1|AAH01964.1| 415|Homo sapiens acyl-Coenzyme A dehydro... 25 8.7
AK000359-1|BAA91109.1| 415|Homo sapiens protein ( Homo sapiens ... 25 8.7
AF260689-1|AAF97922.1| 415|Homo sapiens acyl-CoA dehydrogenase ... 25 8.7
AF126245-1|AAF12736.1| 415|Homo sapiens acyl-Coenzyme A dehydro... 25 8.7
AK074640-1|BAC11107.1| 288|Homo sapiens protein ( Homo sapiens ... 25 8.9
>BC067430-1|AAH67430.1| 491|Homo sapiens cytochrome P450, family 2,
subfamily B, polypeptide 6 protein.
Length = 491
Score = 109 bits (263), Expect = 9e-24
Identities = 79/247 (31%), Positives = 126/247 (51%), Gaps = 6/247 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGP PLP++GNLL + R+ + + +KYG++ + LG VV++ G+E IR
Sbjct: 31 PPGPRPLPLLGNLLQM---DRRGLLKSFL--RFREKYGDVFTVHLGPRPVVMLCGVEAIR 85
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E V E F GR G + F + G++F++G W RRF + +++FG R +
Sbjct: 86 EALVDKAEAFSGR--GKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVE 143
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
I EE + L++ G + +FH NI+ +V GKR+ DQ K+ +L
Sbjct: 144 ERIQEEAQCLIEELRKSKGALMDPTFLFHSITANIICSIVFGKRFHYQDQEFLKMLNLFY 203
Query: 638 RLFKLVDMSGGIL--NFLPFLRHF--VPRLIGFTELQXIHNALHQYLREIIKEHQXNLQL 805
+ F L+ G L F FL++F R + + LQ I NA Y+ +++H+ L
Sbjct: 204 QTFSLISSVFGQLFELFSGFLKYFPGAHRQV-YKNLQEI-NA---YIGHSVEKHRETLDP 258
Query: 806 GAPKDVI 826
AP+D+I
Sbjct: 259 SAPRDLI 265
>AK223113-1|BAD96833.1| 512|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 1 variant protein.
Length = 512
Score = 109 bits (262), Expect = 1e-23
Identities = 74/257 (28%), Positives = 131/257 (50%), Gaps = 12/257 (4%)
Frame = +2
Query: 89 RGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTG 268
+GL PPGP P++G++L++ K HL SQ+YG++L +R+GS VVV++G
Sbjct: 35 KGLKNPPGPWDWPLIGHMLTL------GKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSG 88
Query: 269 IELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGY- 439
++ IR+ V + F+GRPD + +T+ S G+ + GP W RR LK+F
Sbjct: 89 LDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIA 148
Query: 440 ------NSRFMNVYIGEECEALVQLRLADAGEPILVNQMFH--ITIVNILWRLVAGKRYD 595
S ++ ++ +E E L+ P N + +++ N++ + G+RYD
Sbjct: 149 SDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYD 208
Query: 596 LXDQRLKKLCSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIGFTELQXIHNALHQYLRE 772
Q L L +L ++V SG +F+P LR+ P L F +L + + ++++
Sbjct: 209 HNHQELLSLVNLNNNFGEVVG-SGNPADFIPILRYLPNPSLNAFKDL---NEKFYSFMQK 264
Query: 773 IIKEHQXNLQLGAPKDV 823
++KEH + G +D+
Sbjct: 265 MVKEHYKTFEKGHIRDI 281
>X04300-1|CAA27843.1| 512|Homo sapiens P-450 c protein.
Length = 512
Score = 109 bits (261), Expect = 2e-23
Identities = 74/257 (28%), Positives = 131/257 (50%), Gaps = 12/257 (4%)
Frame = +2
Query: 89 RGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTG 268
+GL PPGP P++G++L++ K HL SQ+YG++L +R+GS VVV++G
Sbjct: 35 KGLKNPPGPWGWPLIGHMLTL------GKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSG 88
Query: 269 IELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGY- 439
++ IR+ V + F+GRPD + +T+ S G+ + GP W RR LK+F
Sbjct: 89 LDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIA 148
Query: 440 ------NSRFMNVYIGEECEALVQLRLADAGEPILVNQMFH--ITIVNILWRLVAGKRYD 595
S ++ ++ +E E L+ P N + +++ N++ + G+RYD
Sbjct: 149 SDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYD 208
Query: 596 LXDQRLKKLCSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIGFTELQXIHNALHQYLRE 772
Q L L +L ++V SG +F+P LR+ P L F +L + + ++++
Sbjct: 209 HNHQELLSLVNLNNNFGEVVG-SGNPADFIPILRYLPNPSLNAFKDL---NEKFYSFMQK 264
Query: 773 IIKEHQXNLQLGAPKDV 823
++KEH + G +D+
Sbjct: 265 MVKEHYKTFEKGHIRDI 281
>X02612-1|CAA26458.1| 512|Homo sapiens cytochrome P(1)-450 protein.
Length = 512
Score = 109 bits (261), Expect = 2e-23
Identities = 74/257 (28%), Positives = 131/257 (50%), Gaps = 12/257 (4%)
Frame = +2
Query: 89 RGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTG 268
+GL PPGP P++G++L++ K HL SQ+YG++L +R+GS VVV++G
Sbjct: 35 KGLKNPPGPWGWPLIGHMLTL------GKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSG 88
Query: 269 IELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGY- 439
++ IR+ V + F+GRPD + +T+ S G+ + GP W RR LK+F
Sbjct: 89 LDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIA 148
Query: 440 ------NSRFMNVYIGEECEALVQLRLADAGEPILVNQMFH--ITIVNILWRLVAGKRYD 595
S ++ ++ +E E L+ P N + +++ N++ + G+RYD
Sbjct: 149 SDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYD 208
Query: 596 LXDQRLKKLCSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIGFTELQXIHNALHQYLRE 772
Q L L +L ++V SG +F+P LR+ P L F +L + + ++++
Sbjct: 209 HNHQELLSLVNLNNNFGEVVG-SGNPADFIPILRYLPNPSLNAFKDL---NEKFYSFMQK 264
Query: 773 IIKEHQXNLQLGAPKDV 823
++KEH + G +D+
Sbjct: 265 MVKEHYKTFEKGHIRDI 281
>EF094025-1|ABK41999.1| 512|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 1 protein.
Length = 512
Score = 109 bits (261), Expect = 2e-23
Identities = 74/257 (28%), Positives = 131/257 (50%), Gaps = 12/257 (4%)
Frame = +2
Query: 89 RGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTG 268
+GL PPGP P++G++L++ K HL SQ+YG++L +R+GS VVV++G
Sbjct: 35 KGLKNPPGPWGWPLIGHMLTL------GKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSG 88
Query: 269 IELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGY- 439
++ IR+ V + F+GRPD + +T+ S G+ + GP W RR LK+F
Sbjct: 89 LDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIA 148
Query: 440 ------NSRFMNVYIGEECEALVQLRLADAGEPILVNQMFH--ITIVNILWRLVAGKRYD 595
S ++ ++ +E E L+ P N + +++ N++ + G+RYD
Sbjct: 149 SDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYD 208
Query: 596 LXDQRLKKLCSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIGFTELQXIHNALHQYLRE 772
Q L L +L ++V SG +F+P LR+ P L F +L + + ++++
Sbjct: 209 HNHQELLSLVNLNNNFGEVVG-SGNPADFIPILRYLPNPSLNAFKDL---NEKFYSFMQK 264
Query: 773 IIKEHQXNLQLGAPKDV 823
++KEH + G +D+
Sbjct: 265 MVKEHYKTFEKGHIRDI 281
>BC023019-1|AAH23019.1| 512|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 1 protein.
Length = 512
Score = 109 bits (261), Expect = 2e-23
Identities = 74/257 (28%), Positives = 131/257 (50%), Gaps = 12/257 (4%)
Frame = +2
Query: 89 RGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTG 268
+GL PPGP P++G++L++ K HL SQ+YG++L +R+GS VVV++G
Sbjct: 35 KGLKNPPGPWGWPLIGHMLTL------GKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSG 88
Query: 269 IELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGY- 439
++ IR+ V + F+GRPD + +T+ S G+ + GP W RR LK+F
Sbjct: 89 LDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIA 148
Query: 440 ------NSRFMNVYIGEECEALVQLRLADAGEPILVNQMFH--ITIVNILWRLVAGKRYD 595
S ++ ++ +E E L+ P N + +++ N++ + G+RYD
Sbjct: 149 SDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYD 208
Query: 596 LXDQRLKKLCSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIGFTELQXIHNALHQYLRE 772
Q L L +L ++V SG +F+P LR+ P L F +L + + ++++
Sbjct: 209 HNHQELLSLVNLNNNFGEVVG-SGNPADFIPILRYLPNPSLNAFKDL---NEKFYSFMQK 264
Query: 773 IIKEHQXNLQLGAPKDV 823
++KEH + G +D+
Sbjct: 265 MVKEHYKTFEKGHIRDI 281
>AF253322-1|AAK25727.1| 512|Homo sapiens cytochrome P450 protein.
Length = 512
Score = 109 bits (261), Expect = 2e-23
Identities = 74/257 (28%), Positives = 131/257 (50%), Gaps = 12/257 (4%)
Frame = +2
Query: 89 RGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTG 268
+GL PPGP P++G++L++ K HL SQ+YG++L +R+GS VVV++G
Sbjct: 35 KGLKNPPGPWGWPLIGHMLTL------GKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSG 88
Query: 269 IELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGY- 439
++ IR+ V + F+GRPD + +T+ S G+ + GP W RR LK+F
Sbjct: 89 LDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIA 148
Query: 440 ------NSRFMNVYIGEECEALVQLRLADAGEPILVNQMFH--ITIVNILWRLVAGKRYD 595
S ++ ++ +E E L+ P N + +++ N++ + G+RYD
Sbjct: 149 SDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYD 208
Query: 596 LXDQRLKKLCSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIGFTELQXIHNALHQYLRE 772
Q L L +L ++V SG +F+P LR+ P L F +L + + ++++
Sbjct: 209 HNHQELLSLVNLNNNFGEVVG-SGNPADFIPILRYLPNPSLNAFKDL---NEKFYSFMQK 264
Query: 773 IIKEHQXNLQLGAPKDV 823
++KEH + G +D+
Sbjct: 265 MVKEHYKTFEKGHIRDI 281
>K03191-1|AAA52139.1| 512|Homo sapiens CYP1A1 protein.
Length = 512
Score = 108 bits (260), Expect = 2e-23
Identities = 74/257 (28%), Positives = 130/257 (50%), Gaps = 12/257 (4%)
Frame = +2
Query: 89 RGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTG 268
+GL PPGP P++G++L++ K HL SQ+YG++L +R+GS VVV++G
Sbjct: 35 KGLKNPPGPWGWPLIGHMLTL------GKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSG 88
Query: 269 IELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGY- 439
++ IR+ V + F+GRPD + +T+ S G+ + GP W RR LK+F
Sbjct: 89 LDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIA 148
Query: 440 ------NSRFMNVYIGEECEALVQLRLADAGEPILVNQMFH--ITIVNILWRLVAGKRYD 595
S ++ ++ +E E L+ P N + +++ N++ + G+RYD
Sbjct: 149 SDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYD 208
Query: 596 LXDQRLKKLCSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIGFTELQXIHNALHQYLRE 772
Q L L +L ++V SG F+P LR+ P L F +L + + ++++
Sbjct: 209 HNHQELLSLVNLNNNFGEVVG-SGNPAEFIPILRYLPNPSLNAFKDL---NEKFYSFMQK 264
Query: 773 IIKEHQXNLQLGAPKDV 823
++KEH + G +D+
Sbjct: 265 MVKEHYKTFEKGHIRDI 281
>AY871801-1|AAX62803.1| 483|Homo sapiens cytochrome P450 family 1
subfamily A polypeptide 1 protein.
Length = 483
Score = 108 bits (260), Expect = 2e-23
Identities = 74/257 (28%), Positives = 131/257 (50%), Gaps = 12/257 (4%)
Frame = +2
Query: 89 RGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTG 268
+GL PPGP P++G++L++ K HL SQ+YG++L +R+GS VVV++G
Sbjct: 35 KGLENPPGPWGWPLIGHMLTL------GKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSG 88
Query: 269 IELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGY- 439
++ IR+ V + F+GRPD + +T+ S G+ + GP W RR LK+F
Sbjct: 89 LDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIA 148
Query: 440 ------NSRFMNVYIGEECEALVQLRLADAGEPILVNQMFH--ITIVNILWRLVAGKRYD 595
S ++ ++ +E E L+ P N + +++ N++ + G+RYD
Sbjct: 149 SDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYD 208
Query: 596 LXDQRLKKLCSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIGFTELQXIHNALHQYLRE 772
Q L L +L ++V SG +F+P LR+ P L F +L + + ++++
Sbjct: 209 HNHQELLSLVNLNNNFGEVVG-SGNPADFIPILRYLPNPSLNAFKDL---NEKFYSFMQK 264
Query: 773 IIKEHQXNLQLGAPKDV 823
++KEH + G +D+
Sbjct: 265 MVKEHYKTFEKGHIRDI 281
>M29874-1|AAA52144.1| 491|Homo sapiens CYP2B protein.
Length = 491
Score = 107 bits (258), Expect = 4e-23
Identities = 79/247 (31%), Positives = 125/247 (50%), Gaps = 6/247 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGP PLP++GNLL + R+ + + +KYG++ + LG VV++ G+E IR
Sbjct: 31 PPGPRPLPLLGNLLQM---DRRGLLKSFL--RFREKYGDVFTVHLGPRPVVMLCGVEAIR 85
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E V E F GR G + F + G++F++G W RRF + +++FG R +
Sbjct: 86 EALVDKAEAFSGR--GKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVE 143
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
I EE + L++ G + +F NI+ +V GKR+ DQ K+ +L
Sbjct: 144 ERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFY 203
Query: 638 RLFKLVDMSGGIL--NFLPFLRHF--VPRLIGFTELQXIHNALHQYLREIIKEHQXNLQL 805
+ F L+ G L F FL++F R + + LQ I NA Y+ +++H+ L
Sbjct: 204 QTFSLISSVFGQLFELFSGFLKYFPGAHRQV-YKNLQEI-NA---YIGHSVEKHRETLDP 258
Query: 806 GAPKDVI 826
APKD+I
Sbjct: 259 SAPKDLI 265
>DQ298753-1|ABB84469.1| 491|Homo sapiens cytochrome P450, family 2,
subfamily B, polypeptide 6 protein.
Length = 491
Score = 107 bits (258), Expect = 4e-23
Identities = 79/247 (31%), Positives = 125/247 (50%), Gaps = 6/247 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGP PLP++GNLL + R+ + + +KYG++ + LG VV++ G+E IR
Sbjct: 31 PPGPRPLPLLGNLLQM---DRRGLLKSFL--RFREKYGDVFTVHLGPRPVVMLCGVEAIR 85
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E V E F GR G + F + G++F++G W RRF + +++FG R +
Sbjct: 86 EALVDKAEAFSGR--GKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVE 143
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
I EE + L++ G + +F NI+ +V GKR+ DQ K+ +L
Sbjct: 144 ERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFY 203
Query: 638 RLFKLVDMSGGIL--NFLPFLRHF--VPRLIGFTELQXIHNALHQYLREIIKEHQXNLQL 805
+ F L+ G L F FL++F R + + LQ I NA Y+ +++H+ L
Sbjct: 204 QTFSLISSVFGQLFELFSGFLKYFPGAHRQV-YKNLQEI-NA---YIGHSVEKHRETLDP 258
Query: 806 GAPKDVI 826
APKD+I
Sbjct: 259 SAPKDLI 265
>AF182277-1|AAF13602.1| 491|Homo sapiens cytochrome P450-2B6
protein.
Length = 491
Score = 107 bits (258), Expect = 4e-23
Identities = 72/245 (29%), Positives = 121/245 (49%), Gaps = 4/245 (1%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGP PLP++GNLL + R+ + + +KYG++ + LG VV++ G+E IR
Sbjct: 31 PPGPRPLPLLGNLLQM---DRRGLLKSFL--RFREKYGDVFTVHLGPRPVVMLCGVEAIR 85
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E V E F GR G + F + G++F++G W RRF + +++FG R +
Sbjct: 86 EALVDKAEAFSGR--GKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVE 143
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
EE + L++ G + +FH NI+ +V GKR+ DQ K+ +L
Sbjct: 144 ERTQEEAQCLIEELRKSKGALMDATFLFHSITANIICSIVFGKRFHYQDQEFLKMLNLFY 203
Query: 638 RLFKLVDMSGGIL--NFLPFLRHFVPRLIGFTELQXIHNALHQYLREIIKEHQXNLQLGA 811
+ F L+ G L F FL++F ++ ++ Y+ +++H+ L A
Sbjct: 204 QTFSLISSVFGQLFELFSGFLKYFPG---AHRQVYKNPQEINAYIGHSVEKHRETLDPSA 260
Query: 812 PKDVI 826
P+D+I
Sbjct: 261 PRDLI 265
>AC023172-1|AAF32444.1| 491|Homo sapiens CYP2B6 protein.
Length = 491
Score = 107 bits (258), Expect = 4e-23
Identities = 79/247 (31%), Positives = 125/247 (50%), Gaps = 6/247 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGP PLP++GNLL + R+ + + +KYG++ + LG VV++ G+E IR
Sbjct: 31 PPGPRPLPLLGNLLQM---DRRGLLKSFL--RFREKYGDVFTVHLGPRPVVMLCGVEAIR 85
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E V E F GR G + F + G++F++G W RRF + +++FG R +
Sbjct: 86 EALVDKAEAFSGR--GKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVE 143
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
I EE + L++ G + +F NI+ +V GKR+ DQ K+ +L
Sbjct: 144 ERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFY 203
Query: 638 RLFKLVDMSGGIL--NFLPFLRHF--VPRLIGFTELQXIHNALHQYLREIIKEHQXNLQL 805
+ F L+ G L F FL++F R + + LQ I NA Y+ +++H+ L
Sbjct: 204 QTFSLISSVFGQLFELFSGFLKYFPGAHRQV-YKNLQEI-NA---YIGHSVEKHRETLDP 258
Query: 806 GAPKDVI 826
APKD+I
Sbjct: 259 SAPKDLI 265
>M29873-1|AAA52143.1| 377|Homo sapiens CYP2B protein.
Length = 377
Score = 106 bits (255), Expect = 8e-23
Identities = 77/247 (31%), Positives = 126/247 (51%), Gaps = 6/247 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGP PLP++GNLL + R+ + + +KYG++ + LG VV++ G+E IR
Sbjct: 31 PPGPRPLPLLGNLLQM---DRRGLLKSFL--RFREKYGDVFTVHLGPRPVVMLCGVEAIR 85
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E V N E F GR G M + G++F++G W RRF + +++FG R +
Sbjct: 86 EALVDNAEAFSGR--GKIVIMDPVYQGYGMLFANGNRWKVLRRFSVTTMRDFGMGKRSVE 143
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
I +E + L++ G + +FH NI+ ++ GKR+ DQ K +L
Sbjct: 144 ERIQDEAQCLIEELRKSKGALVDPTFLFHSITANIICSIIFGKRFHYQDQEFLKTLNLFC 203
Query: 638 RLFKLV-DMSGGILN-FLPFLRHF--VPRLIGFTELQXIHNALHQYLREIIKEHQXNLQL 805
+ F L+ +S + F FL++F R + + LQ I NA Y+ +++H+ L
Sbjct: 204 QSFLLISSISSQLFELFSGFLKYFPGAHRQV-YKNLQEI-NA---YIGHSVEKHRETLDP 258
Query: 806 GAPKDVI 826
AP+D+I
Sbjct: 259 SAPRDLI 265
>BC067431-1|AAH67431.1| 491|Homo sapiens cytochrome P450, family 2,
subfamily B, polypeptide 6 protein.
Length = 491
Score = 106 bits (255), Expect = 8e-23
Identities = 79/247 (31%), Positives = 124/247 (50%), Gaps = 6/247 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGP PLP++GNLL + R+ + + +KYG++ + LG VV++ G+E IR
Sbjct: 31 PPGPRPLPLLGNLLQM---DRRGLLKSFL--RFREKYGDVFTVHLGPRPVVMLCGVEAIR 85
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E V E F GR G + F + G++F++G W RRF + +++FG R +
Sbjct: 86 EALVDKAEAFSGR--GKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVE 143
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
I EE + L++ G + +F NI+ +V GKR+ DQ K+ +L
Sbjct: 144 ERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFY 203
Query: 638 RLFKLVDMSGGIL--NFLPFLRHF--VPRLIGFTELQXIHNALHQYLREIIKEHQXNLQL 805
+ F L+ G L F FL +F R + + LQ I NA Y+ +++H+ L
Sbjct: 204 QTFSLISSVFGQLFELFSGFLTYFPGAHRQV-YKNLQEI-NA---YIGHSVEKHRETLDP 258
Query: 806 GAPKDVI 826
APKD+I
Sbjct: 259 SAPKDLI 265
>BC041174-1|AAH41174.1| 377|Homo sapiens CYP2B7P1 protein protein.
Length = 377
Score = 106 bits (255), Expect = 8e-23
Identities = 77/247 (31%), Positives = 126/247 (51%), Gaps = 6/247 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGP PLP++GNLL + R+ + + +KYG++ + LG VV++ G+E IR
Sbjct: 31 PPGPRPLPLLGNLLQM---DRRGLLKSFL--RFREKYGDVFTVHLGPRPVVMLCGVEAIR 85
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E V N E F GR G M + G++F++G W RRF + +++FG R +
Sbjct: 86 EALVDNAEAFSGR--GKIVIMDPVYQGYGMLFANGNRWKVLRRFSVTTMRDFGMGKRSVE 143
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
I +E + L++ G + +FH NI+ ++ GKR+ DQ K +L
Sbjct: 144 ERIQDEAQCLIEELRKSKGALVDPTFLFHSITANIICSIIFGKRFHYQDQEFLKTLNLFC 203
Query: 638 RLFKLV-DMSGGILN-FLPFLRHF--VPRLIGFTELQXIHNALHQYLREIIKEHQXNLQL 805
+ F L+ +S + F FL++F R + + LQ I NA Y+ +++H+ L
Sbjct: 204 QSFLLISSISSQLFELFSGFLKYFPGAHRQV-YKNLQEI-NA---YIGHSVEKHRETLDP 258
Query: 806 GAPKDVI 826
AP+D+I
Sbjct: 259 SAPRDLI 265
>AK223108-1|BAD96828.1| 512|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 1 variant protein.
Length = 512
Score = 106 bits (255), Expect = 8e-23
Identities = 73/257 (28%), Positives = 130/257 (50%), Gaps = 12/257 (4%)
Frame = +2
Query: 89 RGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTG 268
+GL PPGP P++G++L++ K HL SQ+YG++L +R+GS VVV++G
Sbjct: 35 KGLKNPPGPWDWPLIGHMLTL------GKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSG 88
Query: 269 IELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGY- 439
++ IR+ V + F+GRPD + +T+ S G+ + GP W RR LK+F
Sbjct: 89 LDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIA 148
Query: 440 ------NSRFMNVYIGEECEALVQLRLADAGEPILVNQMFH--ITIVNILWRLVAGKRYD 595
S ++ ++ + E L+ P N + +++ N++ + G+RYD
Sbjct: 149 SDPASSTSCYLEEHVSKGAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYD 208
Query: 596 LXDQRLKKLCSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIGFTELQXIHNALHQYLRE 772
Q L L +L ++V SG +F+P LR+ P L F +L + + ++++
Sbjct: 209 HNHQELLSLVNLNNNFGEVVG-SGNPADFIPILRYLPNPSLNAFKDL---NEKFYSFMQK 264
Query: 773 IIKEHQXNLQLGAPKDV 823
++KEH + G +D+
Sbjct: 265 MVKEHYKTFEKGHIRDI 281
>U37143-1|AAC50370.2| 502|Homo sapiens cytochrome P450
monooxygenase CYP2J2 protein.
Length = 502
Score = 105 bits (251), Expect = 3e-22
Identities = 69/214 (32%), Positives = 106/214 (49%), Gaps = 4/214 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
+R R YPPGP LP +GN V F+ HL Q + +KYGNL L LG I+ V+
Sbjct: 36 KRRRPKNYPPGPWRLPFLGNFFLV-----DFEQSHLEVQLFVKKYGNLFSLELGDISAVL 90
Query: 260 VTGIELIRE--VSNREVFEGRPDGFFYTMRS-FGKKLGLVFSDGPTWHRTRRFVLKYLKN 430
+TG+ LI+E + + F RP MR KK GL+ S G W RRF L L+N
Sbjct: 91 ITGLPLIKEALIHMDQNFGNRP---VTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRN 147
Query: 431 FGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQR 610
FG + + I EE + L + + G+P + + + NI+ + G+R++ D
Sbjct: 148 FGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSW 207
Query: 611 LKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVP 709
++L L+ + L + + N P++ F+P
Sbjct: 208 FQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLP 241
>EF122242-1|ABO41977.1| 321|Homo sapiens cytochrome P450 2F1
variant protein.
Length = 321
Score = 105 bits (251), Expect = 3e-22
Identities = 76/253 (30%), Positives = 121/253 (47%), Gaps = 3/253 (1%)
Frame = +2
Query: 77 SRRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
S R +G PPGP PLPI+GNLL + + L S++YG++ + LG VV
Sbjct: 23 SSRDKGKL-PPGPRPLPILGNLLLLCSQDMLTSLTKL-----SKEYGSMYTVHLGPRRVV 76
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKN 430
V++G + ++E V E F GR D + +F K G+ FS G W R+F ++ L+N
Sbjct: 77 VLSGYQAVKEALVDQGEEFSGRGD--YPAFFNFTKGNGIAFSSGDRWKVLRQFSIQILRN 134
Query: 431 FGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQR 610
FG R + I EE L+ GEP + ++ NI+ ++ G R+D D+R
Sbjct: 135 FGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVLFGSRFDYDDER 194
Query: 611 LKKLCSLVMRLFKLVDMS-GGILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREIIKEH 787
L + L+ F+++ G + N P L +VP + L + + +H
Sbjct: 195 LLTIIRLINDNFQIMSSPWGELYNIFPSLLDWVPG--PHQRIFQNFKCLRDLIAHSVHDH 252
Query: 788 QXNLQLGAPKDVI 826
Q +L +P+D I
Sbjct: 253 QASLDPRSPRDFI 265
>BC032594-1|AAH32594.1| 502|Homo sapiens cytochrome P450, family 2,
subfamily J, polypeptide 2 protein.
Length = 502
Score = 105 bits (251), Expect = 3e-22
Identities = 69/214 (32%), Positives = 106/214 (49%), Gaps = 4/214 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
+R R YPPGP LP +GN V F+ HL Q + +KYGNL L LG I+ V+
Sbjct: 36 KRRRPKNYPPGPWRLPFLGNFFLV-----DFEQSHLEVQLFVKKYGNLFSLELGDISAVL 90
Query: 260 VTGIELIRE--VSNREVFEGRPDGFFYTMRS-FGKKLGLVFSDGPTWHRTRRFVLKYLKN 430
+TG+ LI+E + + F RP MR KK GL+ S G W RRF L L+N
Sbjct: 91 ITGLPLIKEALIHMDQNFGNRP---VTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRN 147
Query: 431 FGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQR 610
FG + + I EE + L + + G+P + + + NI+ + G+R++ D
Sbjct: 148 FGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSW 207
Query: 611 LKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVP 709
++L L+ + L + + N P++ F+P
Sbjct: 208 FQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLP 241
>AY426985-1|AAQ93356.1| 502|Homo sapiens cytochrome P450, family 2,
subfamily J, polypeptide 2 protein.
Length = 502
Score = 105 bits (251), Expect = 3e-22
Identities = 69/214 (32%), Positives = 106/214 (49%), Gaps = 4/214 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
+R R YPPGP LP +GN V F+ HL Q + +KYGNL L LG I+ V+
Sbjct: 36 KRRRPKNYPPGPWRLPFLGNFFLV-----DFEQSHLEVQLFVKKYGNLFSLELGDISAVL 90
Query: 260 VTGIELIRE--VSNREVFEGRPDGFFYTMRS-FGKKLGLVFSDGPTWHRTRRFVLKYLKN 430
+TG+ LI+E + + F RP MR KK GL+ S G W RRF L L+N
Sbjct: 91 ITGLPLIKEALIHMDQNFGNRP---VTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRN 147
Query: 431 FGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQR 610
FG + + I EE + L + + G+P + + + NI+ + G+R++ D
Sbjct: 148 FGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSW 207
Query: 611 LKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVP 709
++L L+ + L + + N P++ F+P
Sbjct: 208 FQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLP 241
>AF272142-1|AAM44456.1| 502|Homo sapiens cytochrome P450 protein.
Length = 502
Score = 105 bits (251), Expect = 3e-22
Identities = 69/214 (32%), Positives = 106/214 (49%), Gaps = 4/214 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
+R R YPPGP LP +GN V F+ HL Q + +KYGNL L LG I+ V+
Sbjct: 36 KRRRPKNYPPGPWRLPFLGNFFLV-----DFEQSHLEVQLFVKKYGNLFSLELGDISAVL 90
Query: 260 VTGIELIRE--VSNREVFEGRPDGFFYTMRS-FGKKLGLVFSDGPTWHRTRRFVLKYLKN 430
+TG+ LI+E + + F RP MR KK GL+ S G W RRF L L+N
Sbjct: 91 ITGLPLIKEALIHMDQNFGNRP---VTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRN 147
Query: 431 FGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQR 610
FG + + I EE + L + + G+P + + + NI+ + G+R++ D
Sbjct: 148 FGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSW 207
Query: 611 LKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVP 709
++L L+ + L + + N P++ F+P
Sbjct: 208 FQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLP 241
>AB080265-1|BAB85489.1| 502|Homo sapiens cytochrome P450 2J2
protein.
Length = 502
Score = 105 bits (251), Expect = 3e-22
Identities = 69/214 (32%), Positives = 106/214 (49%), Gaps = 4/214 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
+R R YPPGP LP +GN V F+ HL Q + +KYGNL L LG I+ V+
Sbjct: 36 KRRRPKNYPPGPWRLPFLGNFFLV-----DFEQSHLEVQLFVKKYGNLFSLELGDISAVL 90
Query: 260 VTGIELIRE--VSNREVFEGRPDGFFYTMRS-FGKKLGLVFSDGPTWHRTRRFVLKYLKN 430
+TG+ LI+E + + F RP MR KK GL+ S G W RRF L L+N
Sbjct: 91 ITGLPLIKEALIHMDQNFGNRP---VTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRN 147
Query: 431 FGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQR 610
FG + + I EE + L + + G+P + + + NI+ + G+R++ D
Sbjct: 148 FGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSW 207
Query: 611 LKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVP 709
++L L+ + L + + N P++ F+P
Sbjct: 208 FQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLP 241
>AF144566-1|AAD30164.1| 339|Homo sapiens cytochrome P450
epoxygenase protein.
Length = 339
Score = 104 bits (250), Expect = 3e-22
Identities = 69/214 (32%), Positives = 106/214 (49%), Gaps = 4/214 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
+R R YPPGP LP +GN V F+ HL Q + +KYGNL L LG I+ V+
Sbjct: 5 KRRRPKNYPPGPWRLPFLGNFFLV-----DFEQSHLEVQLFVKKYGNLFSLELGDISAVL 59
Query: 260 VTGIELIRE--VSNREVFEGRPDGFFYTMRS-FGKKLGLVFSDGPTWHRTRRFVLKYLKN 430
+TG+ LI+E + + F RP MR KK GL+ S G W RRF L L+N
Sbjct: 60 ITGLPLIKEALIHMDQNFGNRP---VTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRN 116
Query: 431 FGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQR 610
FG + + I EE + L + + G+P + + + NI+ + G+R++ D
Sbjct: 117 FGLGKKGLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSW 176
Query: 611 LKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVP 709
++L L+ + L + + N P++ F+P
Sbjct: 177 FQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLP 210
>AY220845-1|AAO49806.1| 516|Homo sapiens cytochrome P450 protein.
Length = 516
Score = 103 bits (247), Expect = 8e-22
Identities = 72/237 (30%), Positives = 115/237 (48%), Gaps = 7/237 (2%)
Frame = +2
Query: 101 YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELI 280
YPPGP PLP +GNLL V +++ + C + +++G++ L+L VVV+ G+ +
Sbjct: 33 YPPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFNLQLAWTPVVVLNGLAAV 87
Query: 281 RE--VSNREVFEGRPDGFFYTMRSFG-KKLGLVFSD-GPTWHRTRRFVLKYLKNFGYNSR 448
RE V+ E RP Y + FG + G++ S GP W RRF + L+N G +
Sbjct: 88 REAMVTRGEDTADRPPAPIYQVLGFGPRSQGVILSRYGPAWREQRRFSVSTLRNLGLGKK 147
Query: 449 FMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCS 628
+ ++ EE L AG P N + + N++ L G+R++ D R +L
Sbjct: 148 SLEQWVTEEAACLCAAFADQAGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLD 207
Query: 629 LVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREIIKEHQ 790
L K + SG +LN +P L H +P L G ++ A L E++ EH+
Sbjct: 208 LAQEGLK--EESGFLREVLNAVPVLPH-IPALAG--KVLRFQKAFLTQLDELLTEHR 259
>M21941-1|AAA52160.1| 480|Homo sapiens CYP2C protein.
Length = 480
Score = 102 bits (244), Expect = 2e-21
Identities = 75/246 (30%), Positives = 114/246 (46%), Gaps = 5/246 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLPI+GN+L + K C + ++S+ YG + + G +VV G E ++
Sbjct: 20 PPGPTPLPIIGNMLQI---DVKDICKS--FTNFSKVYGPVFTVYFGMNPIVVFHGYEAVK 74
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + N E F GR G + K LG++ S+G W RRF L L+NFG R +
Sbjct: 75 EALIDNGEEFSGR--GNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIE 132
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
+ EE LV+ P + N++ +V KR+D DQ+ L
Sbjct: 133 DRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQKFLTLMKRFN 192
Query: 638 RLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEHQXNLQLG 808
F++++ + N P L P T + + N Y+RE +KEHQ +L +
Sbjct: 193 ENFRILNSPWIQVCNNFPLLIDCFPG----THNKVLKNVALTRSYIREKVKEHQASLDVN 248
Query: 809 APKDVI 826
P+D I
Sbjct: 249 NPRDFI 254
>EF122241-1|ABO41976.1| 491|Homo sapiens cytochrome P450 2F1
variant protein.
Length = 491
Score = 101 bits (243), Expect = 2e-21
Identities = 75/253 (29%), Positives = 120/253 (47%), Gaps = 3/253 (1%)
Frame = +2
Query: 77 SRRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
S R +G PPGP PL I+GNLL + + L S++YG++ + LG VV
Sbjct: 23 SSRDKGKL-PPGPRPLSILGNLLLLCSQDMLTSLTKL-----SKEYGSMYTVHLGPRRVV 76
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKN 430
V++G + ++E V E F GR D + +F K G+ FS G W R+F ++ L+N
Sbjct: 77 VLSGYQAVKEALVDQGEEFSGRGD--YPAFFNFTKGNGIAFSSGDRWKVLRQFSIQILRN 134
Query: 431 FGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQR 610
FG R + I EE L+ GEP + ++ NI+ ++ G R+D D+R
Sbjct: 135 FGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVLFGSRFDYDDER 194
Query: 611 LKKLCSLVMRLFKLVDMS-GGILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREIIKEH 787
L + L+ F+++ G + N P L +VP + L + + +H
Sbjct: 195 LLTIIRLINDNFQIMSSPWGELYNIFPSLLDWVPG--PHQRIFQNFKCLRDLIAHSVHDH 252
Query: 788 QXNLQLGAPKDVI 826
Q +L +P+D I
Sbjct: 253 QASLDPRSPRDFI 265
>Y00498-1|CAA68550.1| 490|Homo sapiens IIC2 protein.
Length = 490
Score = 101 bits (242), Expect = 3e-21
Identities = 75/246 (30%), Positives = 113/246 (45%), Gaps = 5/246 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLPI+GN+L + K C + ++S+ YG + + G +VV G E ++
Sbjct: 30 PPGPTPLPIIGNMLQI---DVKDICKS--FTNFSKVYGPVFTVYFGMNPIVVFHGYEAVK 84
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + N E F GR G + K LG++ S+G W RRF L L+NFG R +
Sbjct: 85 EALIDNGEEFSGR--GNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIE 142
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
+ EE LV+ P + N++ +V KR+D DQ L
Sbjct: 143 DRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFN 202
Query: 638 RLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEHQXNLQLG 808
F++++ + N P L P T + + N Y+RE +KEHQ +L +
Sbjct: 203 ENFRILNSPWIQVCNNFPLLIDCFPG----THNKVLKNVALTRSYIREKVKEHQASLDVN 258
Query: 809 APKDVI 826
P+D I
Sbjct: 259 NPRDFI 264
>AY514490-1|AAR89907.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 8 protein.
Length = 490
Score = 101 bits (242), Expect = 3e-21
Identities = 75/246 (30%), Positives = 113/246 (45%), Gaps = 5/246 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLPI+GN+L + K C + ++S+ YG + + G +VV G E ++
Sbjct: 30 PPGPTPLPIIGNMLQI---DVKDICKS--FTNFSKVYGPVFTVYFGMNPIVVFHGYEAVK 84
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + N E F GR G + K LG++ S+G W RRF L L+NFG R +
Sbjct: 85 EALIDNGEEFSGR--GNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIE 142
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
+ EE LV+ P + N++ +V KR+D DQ L
Sbjct: 143 DRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFN 202
Query: 638 RLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEHQXNLQLG 808
F++++ + N P L P T + + N Y+RE +KEHQ +L +
Sbjct: 203 ENFRILNSPWIQVCNNFPLLIDCFPG----THNKVLKNVALTRSYIREKVKEHQASLDVN 258
Query: 809 APKDVI 826
P+D I
Sbjct: 259 NPRDFI 264
>AL359672-5|CAH71307.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 8 protein.
Length = 490
Score = 101 bits (242), Expect = 3e-21
Identities = 75/246 (30%), Positives = 113/246 (45%), Gaps = 5/246 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLPI+GN+L + K C + ++S+ YG + + G +VV G E ++
Sbjct: 30 PPGPTPLPIIGNMLQI---DVKDICKS--FTNFSKVYGPVFTVYFGMNPIVVFHGYEAVK 84
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + N E F GR G + K LG++ S+G W RRF L L+NFG R +
Sbjct: 85 EALIDNGEEFSGR--GNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIE 142
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
+ EE LV+ P + N++ +V KR+D DQ L
Sbjct: 143 DRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFN 202
Query: 638 RLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEHQXNLQLG 808
F++++ + N P L P T + + N Y+RE +KEHQ +L +
Sbjct: 203 ENFRILNSPWIQVCNNFPLLIDCFPG----THNKVLKNVALTRSYIREKVKEHQASLDVN 258
Query: 809 APKDVI 826
P+D I
Sbjct: 259 NPRDFI 264
>BC020596-1|AAH20596.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 8 protein.
Length = 490
Score = 101 bits (241), Expect = 4e-21
Identities = 75/246 (30%), Positives = 113/246 (45%), Gaps = 5/246 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLPI+GN+L + K C + ++S+ YG + + G +VV G E ++
Sbjct: 30 PPGPTPLPIIGNMLQI---DVKDICKS--FTNFSKVYGPVFTVYFGMNPIVVFHGYESVK 84
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + N E F GR G + K LG++ S+G W RRF L L+NFG R +
Sbjct: 85 EALIDNGEEFSGR--GNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIE 142
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
+ EE LV+ P + N++ +V KR+D DQ L
Sbjct: 143 DRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFN 202
Query: 638 RLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEHQXNLQLG 808
F++++ + N P L P T + + N Y+RE +KEHQ +L +
Sbjct: 203 ENFRILNSPWIQVCNNFPLLIDCFPG----THNKVLKNVALTRSYIREKVKEHQASLDVN 258
Query: 809 APKDVI 826
P+D I
Sbjct: 259 NPRDFI 264
>M17398-1|AAA35740.1| 393|Homo sapiens protein ( Human cytochrome
P-450 1 mRNA, complete cds, clone Hp1-2. ).
Length = 393
Score = 100 bits (239), Expect = 7e-21
Identities = 74/244 (30%), Positives = 112/244 (45%), Gaps = 5/244 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLPI+GN+L + K C + ++S+ YG + + G +VV G E ++
Sbjct: 30 PPGPTPLPIIGNMLQI---DVKDICKS--FTNFSKVYGPVFTVYFGMNPIVVFHGYEAVK 84
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + N E F GR G + K LG++ S+G W RRF L L+NFG R +
Sbjct: 85 EALIDNGEEFSGR--GNSPISQRITKGLGIISSNGKRWKEIRRFSLTNLRNFGMGKRSIE 142
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
+ EE LV+ P + N++ +V KR+D DQ L
Sbjct: 143 DRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFN 202
Query: 638 RLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEHQXNLQLG 808
F++++ + N P L P T + + N Y+RE +KEHQ +L +
Sbjct: 203 ENFRILNSPWIQVCNNFPLLIDCFPG----THNKVLKNVALTRSYIREKVKEHQASLDVN 258
Query: 809 APKD 820
P+D
Sbjct: 259 NPRD 262
>M17397-1|AAA35739.1| 490|Homo sapiens protein ( Human cytochrome
P-450 1 functional form mRNA, complete cds. ).
Length = 490
Score = 100 bits (239), Expect = 7e-21
Identities = 74/244 (30%), Positives = 112/244 (45%), Gaps = 5/244 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLPI+GN+L + K C + ++S+ YG + + G +VV G E ++
Sbjct: 30 PPGPTPLPIIGNMLQI---DVKDICKS--FTNFSKVYGPVFTVYFGMNPIVVFHGYEAVK 84
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + N E F GR G + K LG++ S+G W RRF L L+NFG R +
Sbjct: 85 EALIDNGEEFSGR--GNSPISQRITKGLGIISSNGKRWKEIRRFSLTNLRNFGMGKRSIE 142
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
+ EE LV+ P + N++ +V KR+D DQ L
Sbjct: 143 DRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFN 202
Query: 638 RLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEHQXNLQLG 808
F++++ + N P L P T + + N Y+RE +KEHQ +L +
Sbjct: 203 ENFRILNSPWIQVCNNFPLLIDCFPG----THNKVLKNVALTRSYIREKVKEHQASLDVN 258
Query: 809 APKD 820
P+D
Sbjct: 259 NPRD 262
>BC109056-1|AAI09057.1| 320|Homo sapiens CYP2F1 protein protein.
Length = 320
Score = 99 bits (238), Expect = 1e-20
Identities = 74/253 (29%), Positives = 120/253 (47%), Gaps = 3/253 (1%)
Frame = +2
Query: 77 SRRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
S R +G PPGP PL I+GNLL + + L S++YG++ + LG VV
Sbjct: 23 SSRDKGKL-PPGPRPLSILGNLLLLCSQDMLTSLTKL-----SKEYGSMYTVHLGPRRVV 76
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKN 430
V++G + ++E V E F GR D + +F K G+ FS G W R+F ++ L+N
Sbjct: 77 VLSGYQAVKEALVDQGEEFSGRGD--YPAFFNFTKGNGIAFSSGDRWKVLRQFSIQILRN 134
Query: 431 FGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQR 610
FG R + I EE L+ GEP + ++ NI+ ++ G R+D D+R
Sbjct: 135 FGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVLFGSRFDYDDER 194
Query: 611 LKKLCSLVMRLFKLVDMS-GGILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREIIKEH 787
L + L+ F+++ G + + P L +VP + L + + +H
Sbjct: 195 LLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPG--PHQRIFQNFKCLRDLIAHSVHDH 252
Query: 788 QXNLQLGAPKDVI 826
Q +L +P+D I
Sbjct: 253 QASLDPRSPRDFI 265
>M21942-1|AAA52161.1| 462|Homo sapiens CYP2C protein.
Length = 462
Score = 99.5 bits (237), Expect = 1e-20
Identities = 74/246 (30%), Positives = 112/246 (45%), Gaps = 5/246 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLPI+GN+L + K C + ++S+ YG + + G +VV G E ++
Sbjct: 2 PPGPTPLPIIGNMLQI---DVKDICKS--FTNFSKVYGPVFTVYFGMNPIVVFHGYEAVK 56
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + N E F GR G + K LG++ S+G W RRF L L+NFG R +
Sbjct: 57 EALIDNGEEFSGR--GNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIE 114
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
+ EE LV P + N++ +V KR+D DQ L
Sbjct: 115 DRVQEEAHCLVDELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFN 174
Query: 638 RLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEHQXNLQLG 808
F++++ + N P L P T + + N Y+RE ++EHQ +L +
Sbjct: 175 ENFRILNSPWIQVCNNFPLLIDCFPG----THNKVLKNVALTRSYIREKVREHQASLDVN 230
Query: 809 APKDVI 826
P+D I
Sbjct: 231 NPRDFI 236
>S46963-1|AAB23864.2| 477|Homo sapiens cytochrome P-450 protein.
Length = 477
Score = 98.3 bits (234), Expect = 3e-20
Identities = 71/247 (28%), Positives = 113/247 (45%), Gaps = 6/247 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLP++GN+L + + +L S+ YG + L G +VV+ G E ++
Sbjct: 17 PPGPTPLPVIGNILQIGIKDISKSLTNL-----SKVYGPVFTLYFGLKPIVVLHGYEAVK 71
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + E F GR G F + G+VFS+G W RRF L L+NFG R +
Sbjct: 72 EALIDLGEEFSGR--GIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIE 129
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
+ EE LV+ P + N++ ++ KR+D DQ+ L +
Sbjct: 130 DRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLN 189
Query: 638 RLFKLVDMSGGIL--NFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEHQXNLQL 805
K++ + NF P + +F T + + N + Y+ E +KEHQ ++ +
Sbjct: 190 ENIKILSSPWIQICNNFSPIIDYFPG-----THNKLLKNVAFMKSYILEKVKEHQESMDM 244
Query: 806 GAPKDVI 826
P+D I
Sbjct: 245 NNPQDFI 251
>M21939-1|AAA52158.1| 485|Homo sapiens CYP2C protein.
Length = 485
Score = 98.3 bits (234), Expect = 3e-20
Identities = 71/247 (28%), Positives = 113/247 (45%), Gaps = 6/247 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLP++GN+L + + +L S+ YG + L G +VV+ G E ++
Sbjct: 25 PPGPTPLPVIGNILQIGIKDISKSLTNL-----SKVYGPVFTLYFGLKPIVVLHGYEAVK 79
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + E F GR G F + G+VFS+G W RRF L L+NFG R +
Sbjct: 80 EALIDLGEEFSGR--GIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIE 137
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
+ EE LV+ P + N++ ++ KR+D DQ+ L +
Sbjct: 138 DRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLN 197
Query: 638 RLFKLVDMSGGIL--NFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEHQXNLQL 805
K++ + NF P + +F T + + N + Y+ E +KEHQ ++ +
Sbjct: 198 ENIKILSSPWIQICNNFSPIIDYFPG-----THNKLLKNVAFMKSYILEKVKEHQESMDM 252
Query: 806 GAPKDVI 826
P+D I
Sbjct: 253 NNPQDFI 259
>M15331-1|AAA52157.1| 485|Homo sapiens CYP2C protein.
Length = 485
Score = 98.3 bits (234), Expect = 3e-20
Identities = 71/247 (28%), Positives = 113/247 (45%), Gaps = 6/247 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLP++GN+L + + +L S+ YG + L G +VV+ G E ++
Sbjct: 25 PPGPTPLPVIGNILQIGIKDISKSLTNL-----SKVYGPVFTLYFGLKPIVVLHGYEAVK 79
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + E F GR G F + G+VFS+G W RRF L L+NFG R +
Sbjct: 80 EALIDLGEEFSGR--GIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIE 137
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
+ EE LV+ P + N++ ++ KR+D DQ+ L +
Sbjct: 138 DRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLN 197
Query: 638 RLFKLVDMSGGIL--NFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEHQXNLQL 805
K++ + NF P + +F T + + N + Y+ E +KEHQ ++ +
Sbjct: 198 ENIKILSSPWIQICNNFSPIIDYFPG-----THNKLLKNVAFMKSYILEKVKEHQESMDM 252
Query: 806 GAPKDVI 826
P+D I
Sbjct: 253 NNPQDFI 259
>L16880-1|AAD13466.1| 273|Homo sapiens cytochrome P-450 2C protein.
Length = 273
Score = 98.3 bits (234), Expect = 3e-20
Identities = 71/247 (28%), Positives = 113/247 (45%), Gaps = 6/247 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLP++GN+L + + +L S+ YG + L G +VV+ G E ++
Sbjct: 30 PPGPTPLPVIGNILQIGIKDISKSLTNL-----SKVYGPVFTLYFGLKPIVVLHGYEAVK 84
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + E F GR G F + G+VFS+G W RRF L L+NFG R +
Sbjct: 85 EALIDLGEEFSGR--GIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIE 142
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
+ EE LV+ P + N++ ++ KR+D DQ+ L +
Sbjct: 143 DRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLN 202
Query: 638 RLFKLVDMSGGIL--NFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEHQXNLQL 805
K++ + NF P + +F T + + N + Y+ E +KEHQ ++ +
Sbjct: 203 ENIKILSSPWIQICNNFSPIIDYFPG-----THNKLLKNVAFMKSYILEKVKEHQESMDM 257
Query: 806 GAPKDVI 826
P+D I
Sbjct: 258 NNPQDFI 264
>D00173-1|BAA00123.1| 487|Homo sapiens cytochrome P-450 protein.
Length = 487
Score = 98.3 bits (234), Expect = 3e-20
Identities = 71/247 (28%), Positives = 113/247 (45%), Gaps = 6/247 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLP++GN+L + + +L S+ YG + L G +VV+ G E ++
Sbjct: 27 PPGPTPLPVIGNILQIGIKDISKSLTNL-----SKVYGPVFTLYFGLKPIVVLHGYEAVK 81
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + E F GR G F + G+VFS+G W RRF L L+NFG R +
Sbjct: 82 EALIDLGEEFSGR--GIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIE 139
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
+ EE LV+ P + N++ ++ KR+D DQ+ L +
Sbjct: 140 DRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLN 199
Query: 638 RLFKLVDMSGGIL--NFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEHQXNLQL 805
K++ + NF P + +F T + + N + Y+ E +KEHQ ++ +
Sbjct: 200 ENIKILSSPWIQICNNFSPIIDYFPG-----THNKLLKNVAFMKSYILEKVKEHQESMDM 254
Query: 806 GAPKDVI 826
P+D I
Sbjct: 255 NNPQDFI 261
>BC125054-1|AAI25055.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 98.3 bits (234), Expect = 3e-20
Identities = 71/247 (28%), Positives = 113/247 (45%), Gaps = 6/247 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLP++GN+L + + +L S+ YG + L G +VV+ G E ++
Sbjct: 30 PPGPTPLPVIGNILQIGIKDISKSLTNL-----SKVYGPVFTLYFGLKPIVVLHGYEAVK 84
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + E F GR G F + G+VFS+G W RRF L L+NFG R +
Sbjct: 85 EALIDLGEEFSGR--GIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIE 142
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
+ EE LV+ P + N++ ++ KR+D DQ+ L +
Sbjct: 143 DRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLN 202
Query: 638 RLFKLVDMSGGIL--NFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEHQXNLQL 805
K++ + NF P + +F T + + N + Y+ E +KEHQ ++ +
Sbjct: 203 ENIKILSSPWIQICNNFSPIIDYFPG-----THNKLLKNVAFMKSYILEKVKEHQESMDM 257
Query: 806 GAPKDVI 826
P+D I
Sbjct: 258 NNPQDFI 264
>AY702706-1|AAT94065.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 98.3 bits (234), Expect = 3e-20
Identities = 71/247 (28%), Positives = 113/247 (45%), Gaps = 6/247 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLP++GN+L + + +L S+ YG + L G +VV+ G E ++
Sbjct: 30 PPGPTPLPVIGNILQIGIKDISKSLTNL-----SKVYGPVFTLYFGLKPIVVLHGYEAVK 84
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + E F GR G F + G+VFS+G W RRF L L+NFG R +
Sbjct: 85 EALIDLGEEFSGR--GIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIE 142
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
+ EE LV+ P + N++ ++ KR+D DQ+ L +
Sbjct: 143 DRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLN 202
Query: 638 RLFKLVDMSGGIL--NFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEHQXNLQL 805
K++ + NF P + +F T + + N + Y+ E +KEHQ ++ +
Sbjct: 203 ENIKILSSPWIQICNNFSPIIDYFPG-----THNKLLKNVAFMKSYILEKVKEHQESMDM 257
Query: 806 GAPKDVI 826
P+D I
Sbjct: 258 NNPQDFI 264
>AY341248-1|AAP88931.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 98.3 bits (234), Expect = 3e-20
Identities = 71/247 (28%), Positives = 113/247 (45%), Gaps = 6/247 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLP++GN+L + + +L S+ YG + L G +VV+ G E ++
Sbjct: 30 PPGPTPLPVIGNILQIGIKDISKSLTNL-----SKVYGPVFTLYFGLKPIVVLHGYEAVK 84
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + E F GR G F + G+VFS+G W RRF L L+NFG R +
Sbjct: 85 EALIDLGEEFSGR--GIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIE 142
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
+ EE LV+ P + N++ ++ KR+D DQ+ L +
Sbjct: 143 DRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLN 202
Query: 638 RLFKLVDMSGGIL--NFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEHQXNLQL 805
K++ + NF P + +F T + + N + Y+ E +KEHQ ++ +
Sbjct: 203 ENIKILSSPWIQICNNFSPIIDYFPG-----THNKLLKNVAFMKSYILEKVKEHQESMDM 257
Query: 806 GAPKDVI 826
P+D I
Sbjct: 258 NNPQDFI 264
>AL359672-1|CAH71303.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 98.3 bits (234), Expect = 3e-20
Identities = 71/247 (28%), Positives = 113/247 (45%), Gaps = 6/247 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLP++GN+L + + +L S+ YG + L G +VV+ G E ++
Sbjct: 30 PPGPTPLPVIGNILQIGIKDISKSLTNL-----SKVYGPVFTLYFGLKPIVVLHGYEAVK 84
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + E F GR G F + G+VFS+G W RRF L L+NFG R +
Sbjct: 85 EALIDLGEEFSGR--GIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIE 142
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
+ EE LV+ P + N++ ++ KR+D DQ+ L +
Sbjct: 143 DRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLN 202
Query: 638 RLFKLVDMSGGIL--NFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEHQXNLQL 805
K++ + NF P + +F T + + N + Y+ E +KEHQ ++ +
Sbjct: 203 ENIKILSSPWIQICNNFSPIIDYFPG-----THNKLLKNVAFMKSYILEKVKEHQESMDM 257
Query: 806 GAPKDVI 826
P+D I
Sbjct: 258 NNPQDFI 264
>DQ282158-1|ABB77906.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 96.7 bits (230), Expect = 9e-20
Identities = 73/245 (29%), Positives = 116/245 (47%), Gaps = 8/245 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R YPPGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYPPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD--GPTWHRTRRFVLKYL 424
V+ G+ +RE V++ E RP + FG + VF GP W RRF + L
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPIIQILGFGPRSQGVFLARYGPAWREQRRFSVSTL 139
Query: 425 KNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXD 604
+N G + + ++ EE L +G P N + + N++ L G+R++ D
Sbjct: 140 RNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 605 QRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREI 775
R +L L K + SG +LN +P L H +P L G ++ A L E+
Sbjct: 200 PRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDEL 254
Query: 776 IKEHQ 790
+ EH+
Sbjct: 255 LTEHR 259
>DQ282157-1|ABB77905.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 96.7 bits (230), Expect = 9e-20
Identities = 73/245 (29%), Positives = 116/245 (47%), Gaps = 8/245 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R YPPGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYPPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD--GPTWHRTRRFVLKYL 424
V+ G+ +RE V++ E RP + FG + VF GP W RRF + L
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPIIQILGFGPRSQGVFLARYGPAWREQRRFSVSTL 139
Query: 425 KNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXD 604
+N G + + ++ EE L +G P N + + N++ L G+R++ D
Sbjct: 140 RNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 605 QRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREI 775
R +L L K + SG +LN +P L H +P L G ++ A L E+
Sbjct: 200 PRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDEL 254
Query: 776 IKEHQ 790
+ EH+
Sbjct: 255 LTEHR 259
>DQ282153-1|ABB77901.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 96.7 bits (230), Expect = 9e-20
Identities = 73/245 (29%), Positives = 116/245 (47%), Gaps = 8/245 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R YPPGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYPPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD--GPTWHRTRRFVLKYL 424
V+ G+ +RE V++ E RP + FG + VF GP W RRF + L
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSISTL 139
Query: 425 KNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXD 604
+N G + + ++ EE L +G P N + + N++ L G+R++ D
Sbjct: 140 RNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 605 QRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREI 775
R +L L K + SG +LN +P L H +P L G ++ A L E+
Sbjct: 200 PRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDEL 254
Query: 776 IKEHQ 790
+ EH+
Sbjct: 255 LTEHR 259
>X08006-1|CAA30807.1| 497|Homo sapiens cytochrome P450 db1 protein.
Length = 497
Score = 96.3 bits (229), Expect = 1e-19
Identities = 73/245 (29%), Positives = 116/245 (47%), Gaps = 8/245 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R YPPGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYPPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD--GPTWHRTRRFVLKYL 424
V+ G+ +RE V++ E RP + FG + VF GP W RRF + L
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTL 139
Query: 425 KNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXD 604
+N G + + ++ EE L +G P N + + N++ L G+R++ D
Sbjct: 140 RNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 605 QRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREI 775
R +L L K + SG +LN +P L H +P L G ++ A L E+
Sbjct: 200 PRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDEL 254
Query: 776 IKEHQ 790
+ EH+
Sbjct: 255 LTEHR 259
>M61856-1|AAB59356.1| 490|Homo sapiens cytochrome protein.
Length = 490
Score = 96.3 bits (229), Expect = 1e-19
Identities = 72/245 (29%), Positives = 114/245 (46%), Gaps = 4/245 (1%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
P GPTPLPI+GN+L + K ++S+ YG + + G +VV+ G E ++
Sbjct: 30 PSGPTPLPIIGNILQL-----DVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVK 84
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + + E F GR G F K LG++FS+G W RRF L L+NFG R +
Sbjct: 85 EALIDHGEEFSGR--GSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIE 142
Query: 458 VYIGEECEALV-QLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLV 634
+ EE LV +LR +A P + N++ ++ R+D DQR L
Sbjct: 143 DRVQEEARCLVEELRKTNA-SPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKF 201
Query: 635 MRLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREIIKEHQXNLQLGA 811
+++ + N P L ++P ++ + Y+ E IKEHQ +L + +
Sbjct: 202 NENLRILSSPWIQVCNNFPALIDYLPG--SHNKIAENFAYIKSYVLERIKEHQESLDMNS 259
Query: 812 PKDVI 826
+D I
Sbjct: 260 ARDFI 264
>M33388-1|AAA53500.1| 497|Homo sapiens cytochrome P450 IID6
protein.
Length = 497
Score = 96.3 bits (229), Expect = 1e-19
Identities = 73/245 (29%), Positives = 116/245 (47%), Gaps = 8/245 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R YPPGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYPPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD--GPTWHRTRRFVLKYL 424
V+ G+ +RE V++ E RP + FG + VF GP W RRF + L
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTL 139
Query: 425 KNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXD 604
+N G + + ++ EE L +G P N + + N++ L G+R++ D
Sbjct: 140 RNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 605 QRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREI 775
R +L L K + SG +LN +P L H +P L G ++ A L E+
Sbjct: 200 PRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDEL 254
Query: 776 IKEHQ 790
+ EH+
Sbjct: 255 LTEHR 259
>M20403-1|AAA52153.1| 497|Homo sapiens CYP2D protein.
Length = 497
Score = 96.3 bits (229), Expect = 1e-19
Identities = 73/245 (29%), Positives = 116/245 (47%), Gaps = 8/245 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R YPPGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYPPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD--GPTWHRTRRFVLKYL 424
V+ G+ +RE V++ E RP + FG + VF GP W RRF + L
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTL 139
Query: 425 KNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXD 604
+N G + + ++ EE L +G P N + + N++ L G+R++ D
Sbjct: 140 RNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 605 QRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREI 775
R +L L K + SG +LN +P L H +P L G ++ A L E+
Sbjct: 200 PRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDEL 254
Query: 776 IKEHQ 790
+ EH+
Sbjct: 255 LTEHR 259
>L16876-1|AAA02630.1| 490|Homo sapiens cytochrome P-4502C18
protein.
Length = 490
Score = 96.3 bits (229), Expect = 1e-19
Identities = 72/245 (29%), Positives = 114/245 (46%), Gaps = 4/245 (1%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
P GPTPLPI+GN+L + K ++S+ YG + + G +VV+ G E ++
Sbjct: 30 PSGPTPLPIIGNILQL-----DVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVK 84
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + + E F GR G F K LG++FS+G W RRF L L+NFG R +
Sbjct: 85 EALIDHGEEFSGR--GSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIE 142
Query: 458 VYIGEECEALV-QLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLV 634
+ EE LV +LR +A P + N++ ++ R+D DQR L
Sbjct: 143 DRVQEEARCLVEELRKTNA-SPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKF 201
Query: 635 MRLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREIIKEHQXNLQLGA 811
+++ + N P L ++P ++ + Y+ E IKEHQ +L + +
Sbjct: 202 NENLRILSSPWIQVCNNFPALIDYLPG--SHNKIAENFAYIKSYVLERIKEHQESLDMNS 259
Query: 812 PKDVI 826
+D I
Sbjct: 260 ARDFI 264
>DQ282160-1|ABB77908.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 96.3 bits (229), Expect = 1e-19
Identities = 73/245 (29%), Positives = 116/245 (47%), Gaps = 8/245 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R YPPGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYPPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD--GPTWHRTRRFVLKYL 424
V+ G+ +RE V++ E RP + FG + VF GP W RRF + L
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTL 139
Query: 425 KNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXD 604
+N G + + ++ EE L +G P N + + N++ L G+R++ D
Sbjct: 140 RNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 605 QRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREI 775
R +L L K + SG +LN +P L H +P L G ++ A L E+
Sbjct: 200 PRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDEL 254
Query: 776 IKEHQ 790
+ EH+
Sbjct: 255 LTEHR 259
>DQ282159-1|ABB77907.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 96.3 bits (229), Expect = 1e-19
Identities = 73/245 (29%), Positives = 116/245 (47%), Gaps = 8/245 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R YPPGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYPPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD--GPTWHRTRRFVLKYL 424
V+ G+ +RE V++ E RP + FG + VF GP W RRF + L
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTL 139
Query: 425 KNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXD 604
+N G + + ++ EE L +G P N + + N++ L G+R++ D
Sbjct: 140 RNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 605 QRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREI 775
R +L L K + SG +LN +P L H +P L G ++ A L E+
Sbjct: 200 PRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDEL 254
Query: 776 IKEHQ 790
+ EH+
Sbjct: 255 LTEHR 259
>DQ282156-1|ABB77904.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 96.3 bits (229), Expect = 1e-19
Identities = 73/245 (29%), Positives = 116/245 (47%), Gaps = 8/245 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R YPPGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYPPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD--GPTWHRTRRFVLKYL 424
V+ G+ +RE V++ E RP + FG + VF GP W RRF + L
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTL 139
Query: 425 KNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXD 604
+N G + + ++ EE L +G P N + + N++ L G+R++ D
Sbjct: 140 RNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 605 QRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREI 775
R +L L K + SG +LN +P L H +P L G ++ A L E+
Sbjct: 200 PRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDEL 254
Query: 776 IKEHQ 790
+ EH+
Sbjct: 255 LTEHR 259
>DQ282151-1|ABB77899.1| 496|Homo sapiens cytochrome P450 2D6
protein.
Length = 496
Score = 96.3 bits (229), Expect = 1e-19
Identities = 73/245 (29%), Positives = 116/245 (47%), Gaps = 8/245 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R YPPGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYPPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD--GPTWHRTRRFVLKYL 424
V+ G+ +RE V++ E RP + FG + VF GP W RRF + L
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTL 139
Query: 425 KNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXD 604
+N G + + ++ EE L +G P N + + N++ L G+R++ D
Sbjct: 140 RNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 605 QRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREI 775
R +L L K + SG +LN +P L H +P L G ++ A L E+
Sbjct: 200 PRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDEL 254
Query: 776 IKEHQ 790
+ EH+
Sbjct: 255 LTEHR 259
>DQ282147-1|ABB77898.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 96.3 bits (229), Expect = 1e-19
Identities = 73/245 (29%), Positives = 116/245 (47%), Gaps = 8/245 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R YPPGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYPPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD--GPTWHRTRRFVLKYL 424
V+ G+ +RE V++ E RP + FG + VF GP W RRF + L
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTL 139
Query: 425 KNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXD 604
+N G + + ++ EE L +G P N + + N++ L G+R++ D
Sbjct: 140 RNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 605 QRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREI 775
R +L L K + SG +LN +P L H +P L G ++ A L E+
Sbjct: 200 PRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDEL 254
Query: 776 IKEHQ 790
+ EH+
Sbjct: 255 LTEHR 259
>DQ282146-1|ABB77897.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 96.3 bits (229), Expect = 1e-19
Identities = 73/245 (29%), Positives = 116/245 (47%), Gaps = 8/245 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R YPPGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYPPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD--GPTWHRTRRFVLKYL 424
V+ G+ +RE V++ E RP + FG + VF GP W RRF + L
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTL 139
Query: 425 KNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXD 604
+N G + + ++ EE L +G P N + + N++ L G+R++ D
Sbjct: 140 RNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 605 QRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREI 775
R +L L K + SG +LN +P L H +P L G ++ A L E+
Sbjct: 200 PRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDEL 254
Query: 776 IKEHQ 790
+ EH+
Sbjct: 255 LTEHR 259
>DQ282145-1|ABB77896.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 96.3 bits (229), Expect = 1e-19
Identities = 73/245 (29%), Positives = 116/245 (47%), Gaps = 8/245 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R YPPGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYPPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD--GPTWHRTRRFVLKYL 424
V+ G+ +RE V++ E RP + FG + VF GP W RRF + L
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTL 139
Query: 425 KNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXD 604
+N G + + ++ EE L +G P N + + N++ L G+R++ D
Sbjct: 140 RNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 605 QRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREI 775
R +L L K + SG +LN +P L H +P L G ++ A L E+
Sbjct: 200 PRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDEL 254
Query: 776 IKEHQ 790
+ EH+
Sbjct: 255 LTEHR 259
>DQ282144-1|ABB77895.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 96.3 bits (229), Expect = 1e-19
Identities = 73/245 (29%), Positives = 116/245 (47%), Gaps = 8/245 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R YPPGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYPPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD--GPTWHRTRRFVLKYL 424
V+ G+ +RE V++ E RP + FG + VF GP W RRF + L
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTL 139
Query: 425 KNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXD 604
+N G + + ++ EE L +G P N + + N++ L G+R++ D
Sbjct: 140 RNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 605 QRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREI 775
R +L L K + SG +LN +P L H +P L G ++ A L E+
Sbjct: 200 PRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDEL 254
Query: 776 IKEHQ 790
+ EH+
Sbjct: 255 LTEHR 259
>BC126858-1|AAI26859.1| 497|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 497
Score = 96.3 bits (229), Expect = 1e-19
Identities = 73/245 (29%), Positives = 116/245 (47%), Gaps = 8/245 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R YPPGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYPPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD--GPTWHRTRRFVLKYL 424
V+ G+ +RE V++ E RP + FG + VF GP W RRF + L
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTL 139
Query: 425 KNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXD 604
+N G + + ++ EE L +G P N + + N++ L G+R++ D
Sbjct: 140 RNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 605 QRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREI 775
R +L L K + SG +LN +P L H +P L G ++ A L E+
Sbjct: 200 PRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDEL 254
Query: 776 IKEHQ 790
+ EH+
Sbjct: 255 LTEHR 259
>BC106758-1|AAI06759.1| 497|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 497
Score = 96.3 bits (229), Expect = 1e-19
Identities = 73/245 (29%), Positives = 116/245 (47%), Gaps = 8/245 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R YPPGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYPPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD--GPTWHRTRRFVLKYL 424
V+ G+ +RE V++ E RP + FG + VF GP W RRF + L
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTL 139
Query: 425 KNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXD 604
+N G + + ++ EE L +G P N + + N++ L G+R++ D
Sbjct: 140 RNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 605 QRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREI 775
R +L L K + SG +LN +P L H +P L G ++ A L E+
Sbjct: 200 PRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDEL 254
Query: 776 IKEHQ 790
+ EH+
Sbjct: 255 LTEHR 259
>BC096259-1|AAH96259.1| 443|Homo sapiens CYP2C18 protein protein.
Length = 443
Score = 96.3 bits (229), Expect = 1e-19
Identities = 72/245 (29%), Positives = 114/245 (46%), Gaps = 4/245 (1%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
P GPTPLPI+GN+L + K ++S+ YG + + G +VV+ G E ++
Sbjct: 30 PSGPTPLPIIGNILQL-----DVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVK 84
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + + E F GR G F K LG++FS+G W RRF L L+NFG R +
Sbjct: 85 EALIDHGEEFSGR--GSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIE 142
Query: 458 VYIGEECEALV-QLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLV 634
+ EE LV +LR +A P + N++ ++ R+D DQR L
Sbjct: 143 DRVQEEARCLVEELRKTNA-SPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKF 201
Query: 635 MRLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREIIKEHQXNLQLGA 811
+++ + N P L ++P ++ + Y+ E IKEHQ +L + +
Sbjct: 202 NENLRILSSPWIQVCNNFPALIDYLPG--SHNKIAENFAYIKSYVLERIKEHQESLDMNS 259
Query: 812 PKDVI 826
+D I
Sbjct: 260 ARDFI 264
>BC096258-1|AAH96258.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 protein.
Length = 490
Score = 96.3 bits (229), Expect = 1e-19
Identities = 72/245 (29%), Positives = 114/245 (46%), Gaps = 4/245 (1%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
P GPTPLPI+GN+L + K ++S+ YG + + G +VV+ G E ++
Sbjct: 30 PSGPTPLPIIGNILQL-----DVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVK 84
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + + E F GR G F K LG++FS+G W RRF L L+NFG R +
Sbjct: 85 EALIDHGEEFSGR--GSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIE 142
Query: 458 VYIGEECEALV-QLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLV 634
+ EE LV +LR +A P + N++ ++ R+D DQR L
Sbjct: 143 DRVQEEARCLVEELRKTNA-SPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKF 201
Query: 635 MRLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREIIKEHQXNLQLGA 811
+++ + N P L ++P ++ + Y+ E IKEHQ +L + +
Sbjct: 202 NENLRILSSPWIQVCNNFPALIDYLPG--SHNKIAENFAYIKSYVLERIKEHQESLDMNS 259
Query: 812 PKDVI 826
+D I
Sbjct: 260 ARDFI 264
>BC096257-1|AAH96257.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 protein.
Length = 490
Score = 96.3 bits (229), Expect = 1e-19
Identities = 72/245 (29%), Positives = 114/245 (46%), Gaps = 4/245 (1%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
P GPTPLPI+GN+L + K ++S+ YG + + G +VV+ G E ++
Sbjct: 30 PSGPTPLPIIGNILQL-----DVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVK 84
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + + E F GR G F K LG++FS+G W RRF L L+NFG R +
Sbjct: 85 EALIDHGEEFSGR--GSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIE 142
Query: 458 VYIGEECEALV-QLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLV 634
+ EE LV +LR +A P + N++ ++ R+D DQR L
Sbjct: 143 DRVQEEARCLVEELRKTNA-SPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKF 201
Query: 635 MRLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREIIKEHQXNLQLGA 811
+++ + N P L ++P ++ + Y+ E IKEHQ +L + +
Sbjct: 202 NENLRILSSPWIQVCNNFPALIDYLPG--SHNKIAENFAYIKSYVLERIKEHQESLDMNS 259
Query: 812 PKDVI 826
+D I
Sbjct: 260 ARDFI 264
>BC075024-1|AAH75024.1| 497|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 497
Score = 96.3 bits (229), Expect = 1e-19
Identities = 73/245 (29%), Positives = 116/245 (47%), Gaps = 8/245 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R YPPGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYPPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD--GPTWHRTRRFVLKYL 424
V+ G+ +RE V++ E RP + FG + VF GP W RRF + L
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTL 139
Query: 425 KNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXD 604
+N G + + ++ EE L +G P N + + N++ L G+R++ D
Sbjct: 140 RNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 605 QRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREI 775
R +L L K + SG +LN +P L H +P L G ++ A L E+
Sbjct: 200 PRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDEL 254
Query: 776 IKEHQ 790
+ EH+
Sbjct: 255 LTEHR 259
>BC075023-1|AAH75023.1| 497|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 497
Score = 96.3 bits (229), Expect = 1e-19
Identities = 73/245 (29%), Positives = 116/245 (47%), Gaps = 8/245 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R YPPGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYPPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD--GPTWHRTRRFVLKYL 424
V+ G+ +RE V++ E RP + FG + VF GP W RRF + L
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTL 139
Query: 425 KNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXD 604
+N G + + ++ EE L +G P N + + N++ L G+R++ D
Sbjct: 140 RNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 605 QRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREI 775
R +L L K + SG +LN +P L H +P L G ++ A L E+
Sbjct: 200 PRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDEL 254
Query: 776 IKEHQ 790
+ EH+
Sbjct: 255 LTEHR 259
>BC069666-1|AAH69666.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 protein.
Length = 490
Score = 96.3 bits (229), Expect = 1e-19
Identities = 72/245 (29%), Positives = 114/245 (46%), Gaps = 4/245 (1%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
P GPTPLPI+GN+L + K ++S+ YG + + G +VV+ G E ++
Sbjct: 30 PSGPTPLPIIGNILQL-----DVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVK 84
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + + E F GR G F K LG++FS+G W RRF L L+NFG R +
Sbjct: 85 EALIDHGEEFSGR--GSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIE 142
Query: 458 VYIGEECEALV-QLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLV 634
+ EE LV +LR +A P + N++ ++ R+D DQR L
Sbjct: 143 DRVQEEARCLVEELRKTNA-SPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKF 201
Query: 635 MRLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREIIKEHQXNLQLGA 811
+++ + N P L ++P ++ + Y+ E IKEHQ +L + +
Sbjct: 202 NENLRILSSPWIQVCNNFPALIDYLPG--SHNKIAENFAYIKSYVLERIKEHQESLDMNS 259
Query: 812 PKDVI 826
+D I
Sbjct: 260 ARDFI 264
>BC067432-1|AAH67432.1| 497|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 497
Score = 96.3 bits (229), Expect = 1e-19
Identities = 73/245 (29%), Positives = 116/245 (47%), Gaps = 8/245 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R YPPGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYPPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD--GPTWHRTRRFVLKYL 424
V+ G+ +RE V++ E RP + FG + VF GP W RRF + L
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTL 139
Query: 425 KNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXD 604
+N G + + ++ EE L +G P N + + N++ L G+R++ D
Sbjct: 140 RNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 605 QRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREI 775
R +L L K + SG +LN +P L H +P L G ++ A L E+
Sbjct: 200 PRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDEL 254
Query: 776 IKEHQ 790
+ EH+
Sbjct: 255 LTEHR 259
>AY545216-1|AAS55001.1| 497|Homo sapiens cytochrome P4502D6
protein.
Length = 497
Score = 96.3 bits (229), Expect = 1e-19
Identities = 73/245 (29%), Positives = 116/245 (47%), Gaps = 8/245 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R YPPGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYPPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD--GPTWHRTRRFVLKYL 424
V+ G+ +RE V++ E RP + FG + VF GP W RRF + L
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTL 139
Query: 425 KNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXD 604
+N G + + ++ EE L +G P N + + N++ L G+R++ D
Sbjct: 140 RNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 605 QRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREI 775
R +L L K + SG +LN +P L H +P L G ++ A L E+
Sbjct: 200 PRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDEL 254
Query: 776 IKEHQ 790
+ EH+
Sbjct: 255 LTEHR 259
>AL583836-1|CAH74067.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 protein.
Length = 490
Score = 96.3 bits (229), Expect = 1e-19
Identities = 72/245 (29%), Positives = 114/245 (46%), Gaps = 4/245 (1%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
P GPTPLPI+GN+L + K ++S+ YG + + G +VV+ G E ++
Sbjct: 30 PSGPTPLPIIGNILQL-----DVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVK 84
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + + E F GR G F K LG++FS+G W RRF L L+NFG R +
Sbjct: 85 EALIDHGEEFSGR--GSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIE 142
Query: 458 VYIGEECEALV-QLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLV 634
+ EE LV +LR +A P + N++ ++ R+D DQR L
Sbjct: 143 DRVQEEARCLVEELRKTNA-SPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKF 201
Query: 635 MRLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREIIKEHQXNLQLGA 811
+++ + N P L ++P ++ + Y+ E IKEHQ +L + +
Sbjct: 202 NENLRILSSPWIQVCNNFPALIDYLPG--SHNKIAENFAYIKSYVLERIKEHQESLDMNS 259
Query: 812 PKDVI 826
+D I
Sbjct: 260 ARDFI 264
>DQ282154-1|ABB77902.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 95.9 bits (228), Expect = 2e-19
Identities = 70/237 (29%), Positives = 113/237 (47%), Gaps = 7/237 (2%)
Frame = +2
Query: 101 YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELI 280
YPPGP PLP +GNLL V +++ + C + +++G++ L+L VVV+ G+ +
Sbjct: 33 YPPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVVVLNGLAAV 87
Query: 281 RE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD--GPTWHRTRRFVLKYLKNFGYNSR 448
RE V++ E RP + FG + VF GP W RRF + L+N G +
Sbjct: 88 REALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKK 147
Query: 449 FMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCS 628
+ ++ EE L +G P N + + N++ L G+R++ D R +L
Sbjct: 148 SLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLD 207
Query: 629 LVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREIIKEHQ 790
L K + SG +LN +P L H +P L G ++ A L E++ EH+
Sbjct: 208 LAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHR 259
>M61854-1|AAB59426.1| 490|Homo sapiens cytochrome protein.
Length = 490
Score = 95.5 bits (227), Expect = 2e-19
Identities = 70/246 (28%), Positives = 112/246 (45%), Gaps = 5/246 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLP++GN+L + + +L S+ YG + L G +VV+ G E+++
Sbjct: 30 PPGPTPLPVIGNILQIDIKDVSKSLTNL-----SKIYGPVFTLYFGLERMVVLHGYEVVK 84
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + E F GR G F + G+VFS+G W RRF L L+NFG R +
Sbjct: 85 EALIDLGEEFSGR--GHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIE 142
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
+ EE LV+ P + N++ ++ KR+D DQ+ L +
Sbjct: 143 DRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLN 202
Query: 638 RLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEHQXNLQLG 808
++V I N P + + P T + + N + + E +KEHQ ++ +
Sbjct: 203 ENIRIVSTPWIQICNNFPTIIDYFPG----THNKLLKNLAFMESDILEKVKEHQESMDIN 258
Query: 809 APKDVI 826
P+D I
Sbjct: 259 NPRDFI 264
>AY796203-1|AAV41877.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 19 protein.
Length = 490
Score = 95.5 bits (227), Expect = 2e-19
Identities = 70/246 (28%), Positives = 112/246 (45%), Gaps = 5/246 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLP++GN+L + + +L S+ YG + L G +VV+ G E+++
Sbjct: 30 PPGPTPLPVIGNILQIDIKDVSKSLTNL-----SKIYGPVFTLYFGLERMVVLHGYEVVK 84
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + E F GR G F + G+VFS+G W RRF L L+NFG R +
Sbjct: 85 EALIDLGEEFSGR--GHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIE 142
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
+ EE LV+ P + N++ ++ KR+D DQ+ L +
Sbjct: 143 DRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLN 202
Query: 638 RLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEHQXNLQLG 808
++V I N P + + P T + + N + + E +KEHQ ++ +
Sbjct: 203 ENIRIVSTPWIQICNNFPTIIDYFPG----THNKLLKNLAFMESDILEKVKEHQESMDIN 258
Query: 809 APKDVI 826
P+D I
Sbjct: 259 NPRDFI 264
>AL583836-2|CAH74068.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 19 protein.
Length = 490
Score = 95.5 bits (227), Expect = 2e-19
Identities = 70/246 (28%), Positives = 112/246 (45%), Gaps = 5/246 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLP++GN+L + + +L S+ YG + L G +VV+ G E+++
Sbjct: 30 PPGPTPLPVIGNILQIDIKDVSKSLTNL-----SKIYGPVFTLYFGLERMVVLHGYEVVK 84
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + E F GR G F + G+VFS+G W RRF L L+NFG R +
Sbjct: 85 EALIDLGEEFSGR--GHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIE 142
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
+ EE LV+ P + N++ ++ KR+D DQ+ L +
Sbjct: 143 DRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLN 202
Query: 638 RLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEHQXNLQLG 808
++V I N P + + P T + + N + + E +KEHQ ++ +
Sbjct: 203 ENIRIVSTPWIQICNNFPTIIDYFPG----THNKLLKNLAFMESDILEKVKEHQESMDIN 258
Query: 809 APKDVI 826
P+D I
Sbjct: 259 NPRDFI 264
>AL133513-2|CAH73444.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 19 protein.
Length = 490
Score = 95.5 bits (227), Expect = 2e-19
Identities = 70/246 (28%), Positives = 112/246 (45%), Gaps = 5/246 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLP++GN+L + + +L S+ YG + L G +VV+ G E+++
Sbjct: 30 PPGPTPLPVIGNILQIDIKDVSKSLTNL-----SKIYGPVFTLYFGLERMVVLHGYEVVK 84
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + E F GR G F + G+VFS+G W RRF L L+NFG R +
Sbjct: 85 EALIDLGEEFSGR--GHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIE 142
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
+ EE LV+ P + N++ ++ KR+D DQ+ L +
Sbjct: 143 DRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLN 202
Query: 638 RLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEHQXNLQLG 808
++V I N P + + P T + + N + + E +KEHQ ++ +
Sbjct: 203 ENIRIVSTPWIQICNNFPTIIDYFPG----THNKLLKNLAFMESDILEKVKEHQESMDIN 258
Query: 809 APKDVI 826
P+D I
Sbjct: 259 NPRDFI 264
>X13930-1|CAA32118.1| 494|Homo sapiens protein ( Human CYP2A4 mRNA
for P-450 IIA4 protein. ).
Length = 494
Score = 95.1 bits (226), Expect = 3e-19
Identities = 73/246 (29%), Positives = 113/246 (45%), Gaps = 5/246 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLP +GN L + E + S++YG + + LG VVV+ G + +R
Sbjct: 34 PPGPTPLPFIGNYLQLNTEQMYNSLMKI-----SERYGPVFTIHLGPRRVVVLCGHDAVR 88
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E V E F GR G T K G+VFS+G + RRF + L++FG R +
Sbjct: 89 EALVDQAEEFSGR--GEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIE 146
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
I EE L+ G I T+ N++ +V G R+D D+ L +++
Sbjct: 147 ERIQEEAGFLIDAHRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMML 206
Query: 638 RLFKLVDMSGGIL--NFLPFLRHFV-PRLIGFTELQXIHNALHQYLREIIKEHQXNLQLG 808
+F+ S G L F ++H P+ F LQ L ++ + ++ +Q L
Sbjct: 207 GIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQ----GLEDFIAKKVEHNQRTLDPN 262
Query: 809 APKDVI 826
+P+D I
Sbjct: 263 SPRDFI 268
>BC096255-1|AAH96255.1| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 6 protein.
Length = 494
Score = 95.1 bits (226), Expect = 3e-19
Identities = 73/246 (29%), Positives = 113/246 (45%), Gaps = 5/246 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLP +GN L + E + S++YG + + LG VVV+ G + +R
Sbjct: 34 PPGPTPLPFIGNYLQLNTEQMYNSLMKI-----SERYGPVFTIHLGPRRVVVLCGHDAVR 88
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E V E F GR G T K G+VFS+G + RRF + L++FG R +
Sbjct: 89 EALVDQAEEFSGR--GEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIE 146
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
I EE L+ G I T+ N++ +V G R+D D+ L +++
Sbjct: 147 ERIQEEAGFLIDAHRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMML 206
Query: 638 RLFKLVDMSGGIL--NFLPFLRHFV-PRLIGFTELQXIHNALHQYLREIIKEHQXNLQLG 808
+F+ S G L F ++H P+ F LQ L ++ + ++ +Q L
Sbjct: 207 GIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQ----GLEDFIAKKVEHNQRTLDPN 262
Query: 809 APKDVI 826
+P+D I
Sbjct: 263 SPRDFI 268
>AK223510-1|BAD97230.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 variant protein.
Length = 490
Score = 95.1 bits (226), Expect = 3e-19
Identities = 72/245 (29%), Positives = 114/245 (46%), Gaps = 4/245 (1%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
P GPTPLPI+GN+L + K ++S+ YG + + G +VV+ G E ++
Sbjct: 30 PSGPTPLPIIGNILQL-----DVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVK 84
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + + E F GR G F K LG++FS+G W RRF L L+NFG R +
Sbjct: 85 EALIDHGEEFFGR--GSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIE 142
Query: 458 VYIGEECEALV-QLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLV 634
+ EE LV +LR +A P + N++ ++ R+D DQR L
Sbjct: 143 DRVQEEARCLVEELRKTNA-SPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKF 201
Query: 635 MRLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREIIKEHQXNLQLGA 811
+++ + N P L ++P ++ + Y+ E IKEHQ +L + +
Sbjct: 202 NENLRILSSPWIQVCNNFPALIDYLPG--SHNKIAENFAYIKSYVLERIKEHQESLDMNS 259
Query: 812 PKDVI 826
+D I
Sbjct: 260 ARDFI 264
>AF372573-1|AAL69652.1| 495|Homo sapiens cytochrome P450 2F1
protein.
Length = 495
Score = 95.1 bits (226), Expect = 3e-19
Identities = 75/257 (29%), Positives = 120/257 (46%), Gaps = 7/257 (2%)
Frame = +2
Query: 77 SRRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
S R +G PPGP PL I+GNLL + + L S++YG++ + LG VV
Sbjct: 23 SSRDKGKL-PPGPRPLSILGNLLLLCSQDMLTSLTKL-----SKEYGSMYTVHLGPRRVV 76
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKN 430
V++G + ++E V E F GR D + +F K G+ FS G W R+F ++ L+N
Sbjct: 77 VLSGYQAVKEALVDQGEEFSGRGD--YPAFFNFTKGNGIAFSSGDRWKVLRQFSIQILRN 134
Query: 431 FGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQR 610
FG R + I EE L+ GEP + ++ NI+ ++ G R+D D+R
Sbjct: 135 FGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVLFGSRFDYDDER 194
Query: 611 LKKLCSLVMRLFKLVDMSGGILNFL-----PFLRHFVPRLIGFTELQXIHNALHQYLREI 775
L + L+ F+++ G L + P L +VP + L +
Sbjct: 195 LLTIIRLINDNFQIMSSPWGELYDILDPRFPSLLDWVPG--PHQRIFQNFKCLRDLIAHS 252
Query: 776 IKEHQXNLQLGAPKDVI 826
+ +HQ +L +P+D I
Sbjct: 253 VHDHQASLDPRSPRDFI 269
>DQ282155-1|ABB77903.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 94.7 bits (225), Expect = 4e-19
Identities = 72/245 (29%), Positives = 116/245 (47%), Gaps = 8/245 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R YPPGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYPPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD--GPTWHRTRRFVLKYL 424
V+ G+ +RE V++ E RP + FG + VF GP W RRF + L
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTL 139
Query: 425 KNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXD 604
+N G + + ++ +E L +G P N + + N++ L G+R++ D
Sbjct: 140 RNLGLGKKSLEQWVTKEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 605 QRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREI 775
R +L L K + SG +LN +P L H +P L G ++ A L E+
Sbjct: 200 PRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDEL 254
Query: 776 IKEHQ 790
+ EH+
Sbjct: 255 LTEHR 259
>X13897-1|CAA32097.1| 489|Homo sapiens protein ( Human mRNA for
cytochrome P-450IIA. ).
Length = 489
Score = 94.3 bits (224), Expect = 5e-19
Identities = 75/254 (29%), Positives = 117/254 (46%), Gaps = 5/254 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
R+++G PPGPTPLP +GN L + E + S++YG + + LG VVV
Sbjct: 22 RKNKGKL-PPGPTPLPFIGNYLQLNTEQMYNSLMKI-----SERYGPVFTIHLGPRRVVV 75
Query: 260 VTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNF 433
+ G + +RE V E F GR G T K G+VFS+G + RRF + L++F
Sbjct: 76 LCGHDAVREALVDQAEEFSGR--GEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDF 133
Query: 434 GYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRL 613
G R + I EE L+ G I T+ N++ +V G R+D D+
Sbjct: 134 GVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEF 193
Query: 614 KKLCSLVMRLFKLVDMSGGIL--NFLPFLRHFV-PRLIGFTELQXIHNALHQYLREIIKE 784
L +++ +F+ S G L F ++H P+ F LQ L ++ + ++
Sbjct: 194 LSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQ----GLEDFIAKKVEH 249
Query: 785 HQXNLQLGAPKDVI 826
Q L +P+D I
Sbjct: 250 KQRTLDPNSPRDFI 263
>M33318-1|AAA52067.1| 494|Homo sapiens CYP2A protein.
Length = 494
Score = 94.3 bits (224), Expect = 5e-19
Identities = 73/246 (29%), Positives = 113/246 (45%), Gaps = 5/246 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLP +GN L + E + S++YG + + LG VVV+ G + +R
Sbjct: 34 PPGPTPLPFIGNYLQLNTEQMYNSLMKI-----SERYGPVFTIHLGPRRVVVLCGHDAVR 88
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E V E F GR G T K G+VFS+G + RRF + L++FG R +
Sbjct: 89 EALVDQAEEFSGR--GEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIE 146
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
I EE L+ G I T+ N++ +V G R+D D+ L +++
Sbjct: 147 ERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMML 206
Query: 638 RLFKLVDMSGGIL--NFLPFLRHFV-PRLIGFTELQXIHNALHQYLREIIKEHQXNLQLG 808
+F+ S G L F ++H P+ F LQ L ++ + ++ +Q L
Sbjct: 207 GIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQ----GLEDFIAKKVEHNQRTLDPN 262
Query: 809 APKDVI 826
+P+D I
Sbjct: 263 SPRDFI 268
>M33317-1|AAA52138.1| 494|Homo sapiens CYP2A protein.
Length = 494
Score = 94.3 bits (224), Expect = 5e-19
Identities = 75/254 (29%), Positives = 121/254 (47%), Gaps = 5/254 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
R+ RG PPGPTPLP +GN L + + + C ++ +S+ YG + + LG VVV
Sbjct: 27 RKSRGKL-PPGPTPLPFIGNYLQL---NTEHICDSIM--KFSECYGPVFTIHLGPRRVVV 80
Query: 260 VTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNF 433
+ G + +RE V E F GR G T K G+ FS+G + RF + L++F
Sbjct: 81 LCGHDAVREALVDQAEEFSGR--GEQATFDWVFKGYGVAFSNGERAKQLLRFAIATLRDF 138
Query: 434 GYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRL 613
G R + I EE L++ + G I T+ N++ +V G R+D D+
Sbjct: 139 GVGKRGIEERIQEESGFLIEAIRSSHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEF 198
Query: 614 KKLCSLVMRLFKLVDMSGGIL--NFLPFLRHFV-PRLIGFTELQXIHNALHQYLREIIKE 784
L S+++ +F+ S G L F ++H P+ F LQ L ++ + ++
Sbjct: 199 LSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQ----GLEDFIAKKVEH 254
Query: 785 HQXNLQLGAPKDVI 826
+Q L +P+D I
Sbjct: 255 NQRTLDPNSPQDFI 268
>BC096256-1|AAH96256.1| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 6 protein.
Length = 494
Score = 94.3 bits (224), Expect = 5e-19
Identities = 73/246 (29%), Positives = 113/246 (45%), Gaps = 5/246 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLP +GN L + E + S++YG + + LG VVV+ G + +R
Sbjct: 34 PPGPTPLPFIGNYLQLNTEQMYNSLMKI-----SERYGPVFTIHLGPRRVVVLCGHDAVR 88
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E V E F GR G T K G+VFS+G + RRF + L++FG R +
Sbjct: 89 EALVDQAEEFSGR--GEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIE 146
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
I EE L+ G I T+ N++ +V G R+D D+ L +++
Sbjct: 147 ERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMML 206
Query: 638 RLFKLVDMSGGIL--NFLPFLRHFV-PRLIGFTELQXIHNALHQYLREIIKEHQXNLQLG 808
+F+ S G L F ++H P+ F LQ L ++ + ++ +Q L
Sbjct: 207 GIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQ----GLEDFIAKKVEHNQRTLDPN 262
Query: 809 APKDVI 826
+P+D I
Sbjct: 263 SPRDFI 268
>BC096254-1|AAH96254.1| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 6 protein.
Length = 494
Score = 94.3 bits (224), Expect = 5e-19
Identities = 73/246 (29%), Positives = 113/246 (45%), Gaps = 5/246 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLP +GN L + E + S++YG + + LG VVV+ G + +R
Sbjct: 34 PPGPTPLPFIGNYLQLNTEQMYNSLMKI-----SERYGPVFTIHLGPRRVVVLCGHDAVR 88
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E V E F GR G T K G+VFS+G + RRF + L++FG R +
Sbjct: 89 EALVDQAEEFSGR--GEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIE 146
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
I EE L+ G I T+ N++ +V G R+D D+ L +++
Sbjct: 147 ERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMML 206
Query: 638 RLFKLVDMSGGIL--NFLPFLRHFV-PRLIGFTELQXIHNALHQYLREIIKEHQXNLQLG 808
+F+ S G L F ++H P+ F LQ L ++ + ++ +Q L
Sbjct: 207 GIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQ----GLEDFIAKKVEHNQRTLDPN 262
Query: 809 APKDVI 826
+P+D I
Sbjct: 263 SPRDFI 268
>BC096253-1|AAH96253.3| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 6 protein.
Length = 494
Score = 94.3 bits (224), Expect = 5e-19
Identities = 73/246 (29%), Positives = 113/246 (45%), Gaps = 5/246 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLP +GN L + E + S++YG + + LG VVV+ G + +R
Sbjct: 34 PPGPTPLPFIGNYLQLNTEQMYNSLMKI-----SERYGPVFTIHLGPRRVVVLCGHDAVR 88
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E V E F GR G T K G+VFS+G + RRF + L++FG R +
Sbjct: 89 EALVDQAEEFSGR--GEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIE 146
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
I EE L+ G I T+ N++ +V G R+D D+ L +++
Sbjct: 147 ERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMML 206
Query: 638 RLFKLVDMSGGIL--NFLPFLRHFV-PRLIGFTELQXIHNALHQYLREIIKEHQXNLQLG 808
+F+ S G L F ++H P+ F LQ L ++ + ++ +Q L
Sbjct: 207 GIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQ----GLEDFIAKKVEHNQRTLDPN 262
Query: 809 APKDVI 826
+P+D I
Sbjct: 263 SPRDFI 268
>AF182275-1|AAF13600.1| 494|Homo sapiens cytochrome P450-2A6
protein.
Length = 494
Score = 94.3 bits (224), Expect = 5e-19
Identities = 73/246 (29%), Positives = 113/246 (45%), Gaps = 5/246 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLP +GN L + E + S++YG + + LG VVV+ G + +R
Sbjct: 34 PPGPTPLPFIGNYLQLNTEQMYNSLMKI-----SERYGPVFTIHLGPRRVVVLCGHDAVR 88
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E V E F GR G T K G+VFS+G + RRF + L++FG R +
Sbjct: 89 EALVDQAEEFSGR--GEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIE 146
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
I EE L+ G I T+ N++ +V G R+D D+ L +++
Sbjct: 147 ERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMML 206
Query: 638 RLFKLVDMSGGIL--NFLPFLRHFV-PRLIGFTELQXIHNALHQYLREIIKEHQXNLQLG 808
+F+ S G L F ++H P+ F LQ L ++ + ++ +Q L
Sbjct: 207 GIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQ----GLEDFIAKKVEHNQRTLDPN 262
Query: 809 APKDVI 826
+P+D I
Sbjct: 263 SPRDFI 268
>AY513608-1|AAR90939.1| 494|Homo sapiens cytochrome P450 2A13
variant 5 protein.
Length = 494
Score = 93.5 bits (222), Expect = 8e-19
Identities = 75/254 (29%), Positives = 116/254 (45%), Gaps = 5/254 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
R+ RG PPGPTPLP +GN L + E + S++YG + + LG VVV
Sbjct: 27 RKSRGKL-PPGPTPLPFIGNYLQLNTEQMYNSLMKI-----SERYGPVFTIHLGPRRVVV 80
Query: 260 VTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNF 433
+ G + ++E V E F GR G T K G+ FS+G + RRF + L+ F
Sbjct: 81 LCGHDAVKEALVDQAEEFSGR--GEQATFDWLFKGYGVAFSNGERAKQLRRFSIATLRGF 138
Query: 434 GYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRL 613
G R + I EE L++ G I T+ N++ +V G R+D D+
Sbjct: 139 GVGKRGIEERIQEEAGFLIEALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEF 198
Query: 614 KKLCSLVMRLFKLVDMSGGIL--NFLPFLRHFV-PRLIGFTELQXIHNALHQYLREIIKE 784
L +++ F+ S G L F ++H P+ F ELQ L ++ + ++
Sbjct: 199 LSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQ----GLEDFIAKKVEH 254
Query: 785 HQXNLQLGAPKDVI 826
+Q L +P+D I
Sbjct: 255 NQRTLDPNSPRDFI 268
>U22028-1|AAB40519.1| 494|Homo sapiens cytochrome P450 protein.
Length = 494
Score = 93.1 bits (221), Expect = 1e-18
Identities = 75/254 (29%), Positives = 115/254 (45%), Gaps = 5/254 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
R+ RG PPGPTPLP +GN L + E + S++YG + + LG VVV
Sbjct: 27 RKSRGKL-PPGPTPLPFIGNYLQLNTEQMYNSLMKI-----SERYGPVFTIHLGPRRVVV 80
Query: 260 VTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNF 433
+ G + ++E V E F GR G T K G+ FS+G + RRF + L+ F
Sbjct: 81 LCGHDAVKEALVDQAEEFSGR--GEQATFDWLFKGYGVAFSNGERAKQLRRFSIATLRGF 138
Query: 434 GYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRL 613
G R + I EE L+ G I T+ N++ +V G R+D D+
Sbjct: 139 GVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEF 198
Query: 614 KKLCSLVMRLFKLVDMSGGIL--NFLPFLRHFV-PRLIGFTELQXIHNALHQYLREIIKE 784
L +++ F+ S G L F ++H P+ F ELQ L ++ + ++
Sbjct: 199 LSLLRMMLGRFQFTGTSTGQLYEMFSSVMKHLPGPQQQAFKELQ----GLEDFIAKKVEH 254
Query: 785 HQXNLQLGAPKDVI 826
+Q L +P+D I
Sbjct: 255 NQRTLDPNSPRDFI 268
>DQ282152-1|ABB77900.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 93.1 bits (221), Expect = 1e-18
Identities = 72/245 (29%), Positives = 115/245 (46%), Gaps = 8/245 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R Y PGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYSPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD--GPTWHRTRRFVLKYL 424
V+ G+ +RE V++ E RP + FG + VF GP W RRF + L
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTL 139
Query: 425 KNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXD 604
+N G + + ++ EE L +G P N + + N++ L G+R++ D
Sbjct: 140 RNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 605 QRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREI 775
R +L L K + SG +LN +P L H +P L G ++ A L E+
Sbjct: 200 PRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDEL 254
Query: 776 IKEHQ 790
+ EH+
Sbjct: 255 LTEHR 259
>DQ211354-2|ABB01372.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 93.1 bits (221), Expect = 1e-18
Identities = 72/245 (29%), Positives = 115/245 (46%), Gaps = 8/245 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R Y PGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYSPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD--GPTWHRTRRFVLKYL 424
V+ G+ +RE V++ E RP + FG + VF GP W RRF + L
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTL 139
Query: 425 KNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXD 604
+N G + + ++ EE L +G P N + + N++ L G+R++ D
Sbjct: 140 RNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 605 QRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREI 775
R +L L K + SG +LN +P L H +P L G ++ A L E+
Sbjct: 200 PRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDEL 254
Query: 776 IKEHQ 790
+ EH+
Sbjct: 255 LTEHR 259
>DQ211353-2|ABB01371.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 93.1 bits (221), Expect = 1e-18
Identities = 72/245 (29%), Positives = 115/245 (46%), Gaps = 8/245 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R Y PGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYSPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD--GPTWHRTRRFVLKYL 424
V+ G+ +RE V++ E RP + FG + VF GP W RRF + L
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTL 139
Query: 425 KNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXD 604
+N G + + ++ EE L +G P N + + N++ L G+R++ D
Sbjct: 140 RNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 605 QRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREI 775
R +L L K + SG +LN +P L H +P L G ++ A L E+
Sbjct: 200 PRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDEL 254
Query: 776 IKEHQ 790
+ EH+
Sbjct: 255 LTEHR 259
>DQ211353-1|ABB01370.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 93.1 bits (221), Expect = 1e-18
Identities = 72/245 (29%), Positives = 115/245 (46%), Gaps = 8/245 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R Y PGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYSPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD--GPTWHRTRRFVLKYL 424
V+ G+ +RE V++ E RP + FG + VF GP W RRF + L
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTL 139
Query: 425 KNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXD 604
+N G + + ++ EE L +G P N + + N++ L G+R++ D
Sbjct: 140 RNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 199
Query: 605 QRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREI 775
R +L L K + SG +LN +P L H +P L G ++ A L E+
Sbjct: 200 PRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDEL 254
Query: 776 IKEHQ 790
+ EH+
Sbjct: 255 LTEHR 259
>J02906-1|AAA52156.1| 491|Homo sapiens CYP2F1 protein.
Length = 491
Score = 92.7 bits (220), Expect = 1e-18
Identities = 76/255 (29%), Positives = 121/255 (47%), Gaps = 5/255 (1%)
Frame = +2
Query: 77 SRRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
S R +G PPGP PL I+GNLL + + L S++YG++ + LG VV
Sbjct: 23 SSRDKGKL-PPGPRPLSILGNLLLLCSQDMLTSLTKL-----SKEYGSMYTVHLGPRRVV 76
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKN 430
V++G + ++E V E F GR D + +F K G+ FS G W R+F ++ L+N
Sbjct: 77 VLSGYQAVKEALVDQGEEFSGRGD--YPAFFNFTKGNGIAFSSGDRWKVLRQFSIQILRN 134
Query: 431 FGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQR 610
FG R + I EE L+ GEP + ++ NI+ ++ G R+D D+R
Sbjct: 135 FGMGKRSIEERILEEGSFLLADVRKTEGEPFDPTFVLSRSVSNIICSVLFGSRFDYDDER 194
Query: 611 LKKLCSLVMRLFKLVDMSGGILNFLPFLRHFVPRLIGFTELQXIHNALHQ---YLREIIK 781
L + L+ F+++ G L L P L+ + + H + Q LR++I
Sbjct: 195 LLTIIRLINDNFQIMSSPWGEL--YDILDPRFPSLLDW--VPGPHQRIFQNFKCLRDLIA 250
Query: 782 EHQXNLQLGAPKDVI 826
+ Q +P+D I
Sbjct: 251 HSVHDHQASSPRDFI 265
>AY513609-1|AAR90940.1| 494|Homo sapiens cytochrome P450 2A13
variant 6 protein.
Length = 494
Score = 92.7 bits (220), Expect = 1e-18
Identities = 75/254 (29%), Positives = 115/254 (45%), Gaps = 5/254 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
R+ RG PPGPTPLP +GN L + E + S++YG + + LG VVV
Sbjct: 27 RKSRGKL-PPGPTPLPFIGNYLQLNTEQMYNSLMKI-----SERYGPVFTIHLGPRRVVV 80
Query: 260 VTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNF 433
+ G + ++E V E F GR G T K G+ FS+G + RRF + L+ F
Sbjct: 81 LCGHDAVKEALVDQAEEFSGR--GEQATFDWLFKGYGVAFSNGERAKQLRRFSIATLRGF 138
Query: 434 GYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRL 613
G R + I EE L+ G I T+ N++ +V G R+D D+
Sbjct: 139 GVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEF 198
Query: 614 KKLCSLVMRLFKLVDMSGGIL--NFLPFLRHFV-PRLIGFTELQXIHNALHQYLREIIKE 784
L +++ F+ S G L F ++H P+ F ELQ L ++ + ++
Sbjct: 199 LSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQ----GLEDFIAKKVEH 254
Query: 785 HQXNLQLGAPKDVI 826
+Q L +P+D I
Sbjct: 255 NQRTLDPNSPRDFI 268
>AY513606-1|AAR90937.1| 494|Homo sapiens cytochrome P450 2A13
variant 3 protein.
Length = 494
Score = 92.7 bits (220), Expect = 1e-18
Identities = 75/254 (29%), Positives = 115/254 (45%), Gaps = 5/254 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
R+ RG PPGPTPLP +GN L + E + S++YG + + LG VVV
Sbjct: 27 RKSRGKL-PPGPTPLPFIGNYLQLNTEQMYNSLMKI-----SERYGPVFTIHLGPRRVVV 80
Query: 260 VTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNF 433
+ G + ++E V E F GR G T K G+ FS+G + RRF + L+ F
Sbjct: 81 LCGHDAVKEALVDQAEEFSGR--GEQATFDWLFKGYGVAFSNGERAKQLRRFSIATLRGF 138
Query: 434 GYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRL 613
G R + I EE L+ G I T+ N++ +V G R+D D+
Sbjct: 139 GVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEF 198
Query: 614 KKLCSLVMRLFKLVDMSGGIL--NFLPFLRHFV-PRLIGFTELQXIHNALHQYLREIIKE 784
L +++ F+ S G L F ++H P+ F ELQ L ++ + ++
Sbjct: 199 LSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQ----GLEDFIAKKVEH 254
Query: 785 HQXNLQLGAPKDVI 826
+Q L +P+D I
Sbjct: 255 NQRTLDPNSPRDFI 268
>AY513605-1|AAR90936.1| 494|Homo sapiens cytochrome P450 2A13
variant 2 protein.
Length = 494
Score = 92.7 bits (220), Expect = 1e-18
Identities = 75/254 (29%), Positives = 115/254 (45%), Gaps = 5/254 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
R+ RG PPGPTPLP +GN L + E + S++YG + + LG VVV
Sbjct: 27 RKSRGKL-PPGPTPLPFIGNYLQLNTEQMYNSLMKI-----SERYGPVFTIHLGPRRVVV 80
Query: 260 VTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNF 433
+ G + ++E V E F GR G T K G+ FS+G + RRF + L+ F
Sbjct: 81 LCGHDAVKEALVDQAEEFSGR--GEQATFDWLFKGYGVAFSNGERAKQLRRFSIATLRGF 138
Query: 434 GYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRL 613
G R + I EE L+ G I T+ N++ +V G R+D D+
Sbjct: 139 GVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEF 198
Query: 614 KKLCSLVMRLFKLVDMSGGIL--NFLPFLRHFV-PRLIGFTELQXIHNALHQYLREIIKE 784
L +++ F+ S G L F ++H P+ F ELQ L ++ + ++
Sbjct: 199 LSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQ----GLEDFIAKKVEH 254
Query: 785 HQXNLQLGAPKDVI 826
+Q L +P+D I
Sbjct: 255 NQRTLDPNSPRDFI 268
>AY513604-1|AAR90935.1| 494|Homo sapiens cytochrome P450 2A13
variant 1 protein.
Length = 494
Score = 92.7 bits (220), Expect = 1e-18
Identities = 75/254 (29%), Positives = 115/254 (45%), Gaps = 5/254 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
R+ RG PPGPTPLP +GN L + E + S++YG + + LG VVV
Sbjct: 27 RKSRGKL-PPGPTPLPFIGNYLQLNTEQMYNSLMKI-----SERYGPVFTIHLGPRRVVV 80
Query: 260 VTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNF 433
+ G + ++E V E F GR G T K G+ FS+G + RRF + L+ F
Sbjct: 81 LCGHDAVKEALVDQAEEFSGR--GEQATFDWLFKGYGVAFSNGERAKQLRRFSIATLRGF 138
Query: 434 GYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRL 613
G R + I EE L+ G I T+ N++ +V G R+D D+
Sbjct: 139 GVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEF 198
Query: 614 KKLCSLVMRLFKLVDMSGGIL--NFLPFLRHFV-PRLIGFTELQXIHNALHQYLREIIKE 784
L +++ F+ S G L F ++H P+ F ELQ L ++ + ++
Sbjct: 199 LSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQ----GLEDFIAKKVEH 254
Query: 785 HQXNLQLGAPKDVI 826
+Q L +P+D I
Sbjct: 255 NQRTLDPNSPRDFI 268
>AF209774-1|AAG35775.1| 494|Homo sapiens cytochrome P450 2A13
protein.
Length = 494
Score = 92.7 bits (220), Expect = 1e-18
Identities = 75/254 (29%), Positives = 115/254 (45%), Gaps = 5/254 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
R+ RG PPGPTPLP +GN L + E + S++YG + + LG VVV
Sbjct: 27 RKSRGKL-PPGPTPLPFIGNYLQLNTEQMYNSLMKI-----SERYGPVFTIHLGPRRVVV 80
Query: 260 VTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNF 433
+ G + ++E V E F GR G T K G+ FS+G + RRF + L+ F
Sbjct: 81 LCGHDAVKEALVDQAEEFSGR--GEQATFDWLFKGYGVAFSNGERAKQLRRFSIATLRGF 138
Query: 434 GYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRL 613
G R + I EE L+ G I T+ N++ +V G R+D D+
Sbjct: 139 GVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEF 198
Query: 614 KKLCSLVMRLFKLVDMSGGIL--NFLPFLRHFV-PRLIGFTELQXIHNALHQYLREIIKE 784
L +++ F+ S G L F ++H P+ F ELQ L ++ + ++
Sbjct: 199 LSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQ----GLEDFIAKKVEH 254
Query: 785 HQXNLQLGAPKDVI 826
+Q L +P+D I
Sbjct: 255 NQRTLDPNSPRDFI 268
>AF182276-1|AAF13601.1| 493|Homo sapiens cytochrome P450-2E1
protein.
Length = 493
Score = 92.7 bits (220), Expect = 1e-18
Identities = 68/252 (26%), Positives = 118/252 (46%), Gaps = 6/252 (2%)
Frame = +2
Query: 86 HRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVT 265
H PPGP PLPI+GNL + + K + +Q++G + L +GS +VV+
Sbjct: 27 HSSWNLPPGPFPLPIIGNLFQL-----ELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 81
Query: 266 GIELIRE--VSNREVFEGRPD-GFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFG 436
G + ++E + ++ F GR D F+ R G++F++GPTW RRF L L+N+G
Sbjct: 82 GYKAVKEALLDYKDEFSGRGDLPAFHAHRD----RGIIFNNGPTWKDIRRFSLTTLRNYG 137
Query: 437 YNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLK 616
+ I E L++ G+P + N++ ++ K +D D++
Sbjct: 138 MGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFL 197
Query: 617 KLCSLVMRLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEH 787
+L L F L+ + N P H++P + + I N + +Y+ E +KEH
Sbjct: 198 RLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPG----SHRKAIKNVAEVKEYVSERVKEH 253
Query: 788 QXNLQLGAPKDV 823
+L P+D+
Sbjct: 254 HQSLDPNCPRDL 265
>U22029-1|AAB40520.1| 494|Homo sapiens cytochrome P450 protein.
Length = 494
Score = 92.3 bits (219), Expect = 2e-18
Identities = 74/254 (29%), Positives = 120/254 (47%), Gaps = 5/254 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
R+ RG PPGPTPLP +GN L + + + C ++ +S+ YG + + LG VVV
Sbjct: 27 RKSRGKL-PPGPTPLPFIGNYLQL---NTEHICDSIM--KFSECYGPVFTIHLGPRRVVV 80
Query: 260 VTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNF 433
+ G + +RE V E F GR G T K G+ FS+G + RF + L++F
Sbjct: 81 LCGHDAVREALVDQAEEFSGR--GEQATFEWVFKGYGVAFSNGERAKQLLRFAIATLRDF 138
Query: 434 GYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRL 613
G R + I EE L++ + G I T+ N++ +V G R+D D+
Sbjct: 139 GVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEF 198
Query: 614 KKLCSLVMRLFKLVDMSGGIL--NFLPFLRHFV-PRLIGFTELQXIHNALHQYLREIIKE 784
L S+++ +F+ S G L F ++H P+ F L L ++ + ++
Sbjct: 199 LSLLSMMLGIFQFTSTSTGQLYEMFSSLMKHLPGPQQQAFKLLL----GLEDFIAKKVEH 254
Query: 785 HQXNLQLGAPKDVI 826
+Q L +P+D I
Sbjct: 255 NQRTLDPNSPQDFI 268
>J02843-1|AAA52155.1| 493|Homo sapiens protein ( Human cytochrome
P450IIE1 (ethanol-inducible) gene, complete cds. ).
Length = 493
Score = 92.3 bits (219), Expect = 2e-18
Identities = 68/252 (26%), Positives = 118/252 (46%), Gaps = 6/252 (2%)
Frame = +2
Query: 86 HRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVT 265
H PPGP PLPI+GNL + + K + +Q++G + L +GS +VV+
Sbjct: 27 HSSWNLPPGPFPLPIIGNLFQL-----ELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 81
Query: 266 GIELIRE--VSNREVFEGRPD-GFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFG 436
G + ++E + ++ F GR D F+ R G++F++GPTW RRF L L+N+G
Sbjct: 82 GYKAVKEALLDYKDEFSGRGDLPAFHAHRD----RGIIFNNGPTWKDIRRFSLTTLRNYG 137
Query: 437 YNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLK 616
+ I E L++ G+P + N++ ++ K +D D++
Sbjct: 138 MGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFL 197
Query: 617 KLCSLVMRLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEH 787
+L L F L+ + N P H++P + + I N + +Y+ E +KEH
Sbjct: 198 RLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPG----SHRKVIKNVAEVKEYVSERVKEH 253
Query: 788 QXNLQLGAPKDV 823
+L P+D+
Sbjct: 254 HQSLDPNCPRDL 265
>J02625-1|AAA35743.1| 493|Homo sapiens protein ( Human cytochrome
P-450j mRNA, complete cds. ).
Length = 493
Score = 92.3 bits (219), Expect = 2e-18
Identities = 68/252 (26%), Positives = 118/252 (46%), Gaps = 6/252 (2%)
Frame = +2
Query: 86 HRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVT 265
H PPGP PLPI+GNL + + K + +Q++G + L +GS +VV+
Sbjct: 27 HSSWNLPPGPFPLPIIGNLFQL-----ELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 81
Query: 266 GIELIRE--VSNREVFEGRPD-GFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFG 436
G + ++E + ++ F GR D F+ R G++F++GPTW RRF L L+N+G
Sbjct: 82 GYKAVKEALLDYKDEFSGRGDLPAFHAHRD----RGIIFNNGPTWKDIRRFSLTTLRNYG 137
Query: 437 YNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLK 616
+ I E L++ G+P + N++ ++ K +D D++
Sbjct: 138 MGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFL 197
Query: 617 KLCSLVMRLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEH 787
+L L F L+ + N P H++P + + I N + +Y+ E +KEH
Sbjct: 198 RLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPG----SHRKVIKNVAEVKEYVSERVKEH 253
Query: 788 QXNLQLGAPKDV 823
+L P+D+
Sbjct: 254 HQSLDPNCPRDL 265
>DQ515958-1|ABF47105.1| 493|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 1 protein.
Length = 493
Score = 92.3 bits (219), Expect = 2e-18
Identities = 68/252 (26%), Positives = 118/252 (46%), Gaps = 6/252 (2%)
Frame = +2
Query: 86 HRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVT 265
H PPGP PLPI+GNL + + K + +Q++G + L +GS +VV+
Sbjct: 27 HSSWNLPPGPFPLPIIGNLFQL-----ELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 81
Query: 266 GIELIRE--VSNREVFEGRPD-GFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFG 436
G + ++E + ++ F GR D F+ R G++F++GPTW RRF L L+N+G
Sbjct: 82 GYKAVKEALLDYKDEFSGRGDLPAFHAHRD----RGIIFNNGPTWKDIRRFSLTTLRNYG 137
Query: 437 YNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLK 616
+ I E L++ G+P + N++ ++ K +D D++
Sbjct: 138 MGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFL 197
Query: 617 KLCSLVMRLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEH 787
+L L F L+ + N P H++P + + I N + +Y+ E +KEH
Sbjct: 198 RLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPG----SHRKVIKNVAEVKEYVSERVKEH 253
Query: 788 QXNLQLGAPKDV 823
+L P+D+
Sbjct: 254 HQSLDPNCPRDL 265
>DQ149222-1|AAZ77710.1| 493|Homo sapiens cytochrome P450 2E1
protein.
Length = 493
Score = 92.3 bits (219), Expect = 2e-18
Identities = 68/252 (26%), Positives = 118/252 (46%), Gaps = 6/252 (2%)
Frame = +2
Query: 86 HRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVT 265
H PPGP PLPI+GNL + + K + +Q++G + L +GS +VV+
Sbjct: 27 HSSWNLPPGPFPLPIIGNLFQL-----ELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 81
Query: 266 GIELIRE--VSNREVFEGRPD-GFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFG 436
G + ++E + ++ F GR D F+ R G++F++GPTW RRF L L+N+G
Sbjct: 82 GYKAVKEALLDYKDEFSGRGDLPAFHAHRD----RGIIFNNGPTWKDIRRFSLTTLRNYG 137
Query: 437 YNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLK 616
+ I E L++ G+P + N++ ++ K +D D++
Sbjct: 138 MGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFL 197
Query: 617 KLCSLVMRLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEH 787
+L L F L+ + N P H++P + + I N + +Y+ E +KEH
Sbjct: 198 RLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPG----SHRKVIKNVAEVKEYVSERVKEH 253
Query: 788 QXNLQLGAPKDV 823
+L P+D+
Sbjct: 254 HQSLDPNCPRDL 265
>BC117165-1|AAI17166.1| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 7 protein.
Length = 494
Score = 92.3 bits (219), Expect = 2e-18
Identities = 74/254 (29%), Positives = 120/254 (47%), Gaps = 5/254 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
R+ RG PPGPTPLP +GN L + + + C ++ +S+ YG + + LG VV
Sbjct: 27 RKSRGKL-PPGPTPLPFIGNYLQL---NTEHICDSIM--KFSECYGPVFTIHLGPRRAVV 80
Query: 260 VTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNF 433
+ G + +RE V E F GR G T K G+ FS+G + RF + L++F
Sbjct: 81 LCGHDAVREALVDQAEEFSGR--GEQATFDWVFKGYGVAFSNGERAKQLLRFAIATLRDF 138
Query: 434 GYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRL 613
G R + I EE L++ + G I T+ N++ +V G R+D D+
Sbjct: 139 GVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEF 198
Query: 614 KKLCSLVMRLFKLVDMSGGIL--NFLPFLRHFV-PRLIGFTELQXIHNALHQYLREIIKE 784
L S+++ +F+ S G L F ++H P+ F LQ L ++ + ++
Sbjct: 199 LSLLSVMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQ----GLEDFIAKKVEH 254
Query: 785 HQXNLQLGAPKDVI 826
+Q L +P+D I
Sbjct: 255 NQRTLDPNSPRDFI 268
>AL161645-2|CAH70047.1| 493|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 1 protein.
Length = 493
Score = 92.3 bits (219), Expect = 2e-18
Identities = 68/252 (26%), Positives = 118/252 (46%), Gaps = 6/252 (2%)
Frame = +2
Query: 86 HRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVT 265
H PPGP PLPI+GNL + + K + +Q++G + L +GS +VV+
Sbjct: 27 HSSWNLPPGPFPLPIIGNLFQL-----ELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 81
Query: 266 GIELIRE--VSNREVFEGRPD-GFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFG 436
G + ++E + ++ F GR D F+ R G++F++GPTW RRF L L+N+G
Sbjct: 82 GYKAVKEALLDYKDEFSGRGDLPAFHAHRD----RGIIFNNGPTWKDIRRFSLTTLRNYG 137
Query: 437 YNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLK 616
+ I E L++ G+P + N++ ++ K +D D++
Sbjct: 138 MGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFL 197
Query: 617 KLCSLVMRLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEH 787
+L L F L+ + N P H++P + + I N + +Y+ E +KEH
Sbjct: 198 RLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPG----SHRKVIKNVAEVKEYVSERVKEH 253
Query: 788 QXNLQLGAPKDV 823
+L P+D+
Sbjct: 254 HQSLDPNCPRDL 265
>U22027-1|AAB40518.1| 494|Homo sapiens cytochrome P450 protein.
Length = 494
Score = 91.9 bits (218), Expect = 3e-18
Identities = 72/246 (29%), Positives = 114/246 (46%), Gaps = 5/246 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLP +GN L + E + S++YG + + LG VVV+ G + +R
Sbjct: 34 PPGPTPLPFIGNYLQLNTEQMYNSLMKI-----SERYGPVFTIHLGPRRVVVLCGHDAVR 88
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E V E F GR G T K G+VFS+G + RF + L++FG R +
Sbjct: 89 EALVDQAEEFSGR--GEQATFDWVFKGYGVVFSNGERAKQLLRFAIATLRDFGVGKRGIE 146
Query: 458 VYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVM 637
I EE L++ + G I T+ N++ +V G R+D D+ L +++
Sbjct: 147 ERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMML 206
Query: 638 RLFKLVDMSGGIL--NFLPFLRHFV-PRLIGFTELQXIHNALHQYLREIIKEHQXNLQLG 808
+F+ S G L F ++H P+ F LQ L ++ + ++ +Q L
Sbjct: 207 GIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQ----GLEDFIAKKVEHNQRTLDPN 262
Query: 809 APKDVI 826
+P+D I
Sbjct: 263 SPRDFI 268
>BC067433-1|AAH67433.1| 493|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 1 protein.
Length = 493
Score = 91.9 bits (218), Expect = 3e-18
Identities = 68/252 (26%), Positives = 118/252 (46%), Gaps = 6/252 (2%)
Frame = +2
Query: 86 HRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVT 265
H PPGP PLPI+GNL + + K + +Q++G + L +GS +VV+
Sbjct: 27 HSSWNLPPGPFPLPIIGNLFQL-----ELKNIPKSFTRLAQRFGPVFTLCVGSQRMVVMH 81
Query: 266 GIELIRE--VSNREVFEGRPD-GFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFG 436
G + ++E + ++ F GR D F+ R G++F++GPTW RRF L L+N+G
Sbjct: 82 GYKAVKEALLDYKDEFSGRGDLPAFHAHRD----RGIIFNNGPTWKDIRRFSLTTLRNYG 137
Query: 437 YNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLK 616
+ I E L++ G+P + N++ ++ K +D D++
Sbjct: 138 MGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFL 197
Query: 617 KLCSLVMRLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEH 787
+L L F L+ + N P H++P + + I N + +Y+ E +KEH
Sbjct: 198 RLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPG----SHRKVIKNVAEVKEYVSERVKEH 253
Query: 788 QXNLQLGAPKDV 823
+L P+D+
Sbjct: 254 HQSLDPNCPRDL 265
>AF084225-1|AAD13753.1| 462|Homo sapiens cytochrome P450 2E1
protein.
Length = 462
Score = 91.9 bits (218), Expect = 3e-18
Identities = 67/246 (27%), Positives = 117/246 (47%), Gaps = 6/246 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGP PLPI+GNL + + K + +Q++G + L +GS +VV+ G + ++
Sbjct: 2 PPGPFPLPIIGNLFQL-----ELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVK 56
Query: 284 E--VSNREVFEGRPD-GFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFM 454
E + ++ F GR D F+ R G++F++GPTW RRF L L+N+G +
Sbjct: 57 EALLDYKDEFSGRGDLPAFHAHRD----RGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGN 112
Query: 455 NVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLV 634
I E L++ G+P + N++ ++ K +D D++ +L L
Sbjct: 113 ESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLF 172
Query: 635 MRLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEHQXNLQL 805
F L+ + N P H++P + + I N + +Y+ E +KEH +L
Sbjct: 173 NENFHLLSTPWLQLYNNFPSFLHYLPG----SHRKVIKNVAEVKEYVSERVKEHHQSLDP 228
Query: 806 GAPKDV 823
P+D+
Sbjct: 229 NCPRDL 234
>DQ282162-1|ABB77909.1| 500|Homo sapiens cytochrome P450 2D6
protein.
Length = 500
Score = 90.6 bits (215), Expect = 6e-18
Identities = 73/248 (29%), Positives = 116/248 (46%), Gaps = 11/248 (4%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R YPPGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYPPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD--GPTWHRTRRFVLKYL 424
V+ G+ +RE V++ E RP + FG + VF GP W RRF + L
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPIIQILGFGPRSQGVFLARYGPAWREQRRFSVSTL 139
Query: 425 KNFGYNSRFMNVYIGEECEALVQLRLADAG---EPILVNQMFHITIVNILWRLVAGKRYD 595
+N G + + ++ EE L +G P N + + N++ L G+R++
Sbjct: 140 RNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPFRPNGLLDKAVSNVIASLTCGRRFE 199
Query: 596 LXDQRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNALHQYL 766
D R +L L K + SG +LN +P L H +P L G ++ A L
Sbjct: 200 YDDPRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQL 254
Query: 767 REIIKEHQ 790
E++ EH+
Sbjct: 255 DELLTEHR 262
>BC132767-1|AAI32768.1| 544|Homo sapiens cytochrome P450, family 2,
subfamily U, polypeptide 1 protein.
Length = 544
Score = 90.6 bits (215), Expect = 6e-18
Identities = 79/272 (29%), Positives = 129/272 (47%), Gaps = 23/272 (8%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVL---------WESRKFKCH---------HLIWQSWS 205
RR R PPGPTP P+VGN VL W S + + ++ +
Sbjct: 52 RRRRARGIPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLA 111
Query: 206 QKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD 379
+ YG++ +G VVV++ +RE V EVF RP ++ + K+ G+VF+
Sbjct: 112 RVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVT--KEKGVVFAH 169
Query: 380 -GPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGE-PILVNQMFHITI 553
GP W + R+F L++FG + I EE + V+ + GE P + +
Sbjct: 170 YGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFK-YVKAEMQKHGEDPFCPFSIISNAV 228
Query: 554 VNILWRLVAGKRYDLXDQRLKKLCSLVMRLFKLVDMSGGIL-NFLPFLRHFVPRLIGFTE 730
NI+ L G+R+D + KK+ + R ++ S +L N P+L +++P F E
Sbjct: 229 SNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWL-YYLP-FGPFKE 286
Query: 731 LQXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
L+ I + +L++IIK+HQ +L P+D I
Sbjct: 287 LRQIEKDITSFLKKIIKDHQESLDRENPQDFI 318
>AY343323-1|AAQ21380.1| 544|Homo sapiens cytochrome P450 protein.
Length = 544
Score = 90.6 bits (215), Expect = 6e-18
Identities = 79/272 (29%), Positives = 129/272 (47%), Gaps = 23/272 (8%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVL---------WESRKFKCH---------HLIWQSWS 205
RR R PPGPTP P+VGN VL W S + + ++ +
Sbjct: 52 RRRRARGIPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLA 111
Query: 206 QKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD 379
+ YG++ +G VVV++ +RE V EVF RP ++ + K+ G+VF+
Sbjct: 112 RVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVT--KEKGVVFAH 169
Query: 380 -GPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGE-PILVNQMFHITI 553
GP W + R+F L++FG + I EE + V+ + GE P + +
Sbjct: 170 YGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFK-YVKAEMQKHGEDPFCPFSIISNAV 228
Query: 554 VNILWRLVAGKRYDLXDQRLKKLCSLVMRLFKLVDMSGGIL-NFLPFLRHFVPRLIGFTE 730
NI+ L G+R+D + KK+ + R ++ S +L N P+L +++P F E
Sbjct: 229 SNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWL-YYLP-FGPFKE 286
Query: 731 LQXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
L+ I + +L++IIK+HQ +L P+D I
Sbjct: 287 LRQIEKDITSFLKKIIKDHQESLDRENPQDFI 318
>AY310359-1|AAQ76692.1| 484|Homo sapiens cytochrome P450 1A1
variant protein.
Length = 484
Score = 90.6 bits (215), Expect = 6e-18
Identities = 69/254 (27%), Positives = 124/254 (48%), Gaps = 11/254 (4%)
Frame = +2
Query: 89 RGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTG 268
+GL PPGP P++G++L++ K HL SQ+YG++L +R+GS VVV++G
Sbjct: 35 KGLKNPPGPWGWPLIGHMLTL------GKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSG 88
Query: 269 IELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGY- 439
++ IR+ V + F+GRPD + +T+ S G+ + GP W RR LK+F
Sbjct: 89 LDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIA 148
Query: 440 ------NSRFMNVYIGEECEALVQLRLADAGEPILVNQMFH--ITIVNILWRLVAGKRYD 595
S ++ ++ +E E L+ P N + +++ N++ + G+RYD
Sbjct: 149 SDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYD 208
Query: 596 LXDQRLKKLCSLVMRLFKLVDMSGGILNFLPFLRHFVPRLIGFTELQXIHNALHQYLREI 775
Q L L +L FK D++ +F+ + + ++ I ++L ++ +E
Sbjct: 209 HNHQELLSLVNL--NAFK--DLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEK 264
Query: 776 IKEHQXNLQLGAPK 817
+ N+QL K
Sbjct: 265 QLDENANVQLSDEK 278
>BC067435-1|AAH67435.1| 493|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 1 protein.
Length = 493
Score = 90.2 bits (214), Expect = 8e-18
Identities = 67/252 (26%), Positives = 117/252 (46%), Gaps = 6/252 (2%)
Frame = +2
Query: 86 HRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVT 265
H PPGP PLPI+GNL + + K + +Q++G + L +GS +VV+
Sbjct: 27 HSSWNLPPGPFPLPIIGNLFQL-----ELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 81
Query: 266 GIELIRE--VSNREVFEGRPD-GFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFG 436
G + ++E + ++ F GR D F+ R G++F++GP W RRF L L+N+G
Sbjct: 82 GYKAVKEALLDYKDEFSGRGDLPAFHAHRD----RGIIFNNGPAWKDIRRFSLTTLRNYG 137
Query: 437 YNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLK 616
+ I E L++ G+P + N++ ++ K +D D++
Sbjct: 138 MGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFL 197
Query: 617 KLCSLVMRLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEH 787
+L L F L+ + N P H++P + + I N + +Y+ E +KEH
Sbjct: 198 RLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPG----SHRKVIKNVAEVKEYVSERVKEH 253
Query: 788 QXNLQLGAPKDV 823
+L P+D+
Sbjct: 254 HQSLDPNCPRDL 265
>AM236046-1|CAJ84703.1| 229|Homo sapiens cytochrome P450 1A1
protein.
Length = 229
Score = 89.0 bits (211), Expect = 2e-17
Identities = 58/192 (30%), Positives = 98/192 (51%), Gaps = 11/192 (5%)
Frame = +2
Query: 89 RGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTG 268
+GL PPGP P++G++L++ K HL SQ+YG++L +R+GS VVV++G
Sbjct: 35 KGLKNPPGPWGWPLIGHMLTL------GKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSG 88
Query: 269 IELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGY- 439
++ IR+ V + F+GRPD + +T+ S G+ + GP W RR LK+F
Sbjct: 89 LDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIA 148
Query: 440 ------NSRFMNVYIGEECEALVQLRLADAGEPILVNQMFH--ITIVNILWRLVAGKRYD 595
S ++ ++ +E E L+ P N + +++ N++ + G+RYD
Sbjct: 149 SDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYD 208
Query: 596 LXDQRLKKLCSL 631
Q L L +L
Sbjct: 209 HNHQELLSLVNL 220
>BC096260-1|AAH96260.1| 431|Homo sapiens CYP2C18 protein protein.
Length = 431
Score = 84.2 bits (199), Expect = 5e-16
Identities = 58/176 (32%), Positives = 86/176 (48%), Gaps = 3/176 (1%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
P GPTPLPI+GN+L + K ++S+ YG + + G +VV+ G E ++
Sbjct: 30 PSGPTPLPIIGNILQL-----DVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVK 84
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + + E F GR G F K LG++FS+G W RRF L L+NFG R +
Sbjct: 85 EALIDHGEEFSGR--GSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIE 142
Query: 458 VYIGEECEALV-QLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKL 622
+ EE LV +LR +A P + N++ ++ R+D DQR L
Sbjct: 143 DRVQEEARCLVEELRKTNA-SPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNL 197
>Z00036-1|CAA77335.1| 515|Homo sapiens protein ( Human mRNA for
cytochrome P-3-450. ).
Length = 515
Score = 82.6 bits (195), Expect = 2e-15
Identities = 66/259 (25%), Positives = 127/259 (49%), Gaps = 14/259 (5%)
Frame = +2
Query: 89 RGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTG 268
+GL PP P P++G++L++ K HL SQ+YG++L +R+GS V+V++
Sbjct: 37 KGLKSPPEPWGWPLLGHVLTL------GKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSR 90
Query: 269 IELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGY- 439
++ IR+ V + F+GRPD + T+ + G+ L GP W RR L F
Sbjct: 91 LDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIA 150
Query: 440 ------NSRFMNVYIGEECEALV---QLRLADAGEPILVNQMFHITIVNILWRLVAGKRY 592
+S ++ ++ +E +AL+ Q +A G NQ+ +++ N++ + G+ +
Sbjct: 151 SDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVV-VSVANVIGAMCFGQHF 209
Query: 593 DLXDQRLKKLCSLVMRLFKLVD--MSGGILNFLPFLRHFVPRLIGFTELQXIHNALHQYL 766
+ ++ SLV + V+ SG L+F P LR ++P + + +L
Sbjct: 210 ---PESSDEMLSLVKNTHEFVETASSGNPLDFFPILR-YLPN-PALQRFKAFNQRFLWFL 264
Query: 767 REIIKEHQXNLQLGAPKDV 823
++ ++EH + + +D+
Sbjct: 265 QKTVQEHYQDFDKNSVRDI 283
>M55053-1|AAA52146.1| 515|Homo sapiens cytochrome P3-450 protein.
Length = 515
Score = 82.6 bits (195), Expect = 2e-15
Identities = 66/259 (25%), Positives = 127/259 (49%), Gaps = 14/259 (5%)
Frame = +2
Query: 89 RGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTG 268
+GL PP P P++G++L++ K HL SQ+YG++L +R+GS V+V++
Sbjct: 37 KGLKSPPEPWGWPLLGHVLTL------GKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSR 90
Query: 269 IELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGY- 439
++ IR+ V + F+GRPD + T+ + G+ L GP W RR L F
Sbjct: 91 LDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIA 150
Query: 440 ------NSRFMNVYIGEECEALV---QLRLADAGEPILVNQMFHITIVNILWRLVAGKRY 592
+S ++ ++ +E +AL+ Q +A G NQ+ +++ N++ + G+ +
Sbjct: 151 SDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVV-VSVANVIGAMCFGQHF 209
Query: 593 DLXDQRLKKLCSLVMRLFKLVD--MSGGILNFLPFLRHFVPRLIGFTELQXIHNALHQYL 766
+ ++ SLV + V+ SG L+F P LR ++P + + +L
Sbjct: 210 ---PESSDEMLSLVKNTHEFVETASSGNPLDFFPILR-YLPN-PALQRFKAFNQRFLWFL 264
Query: 767 REIIKEHQXNLQLGAPKDV 823
++ ++EH + + +D+
Sbjct: 265 QKTVQEHYQDFDKNSVRDI 283
>M31667-1|AAA52163.1| 515|Homo sapiens CYP1A2 protein.
Length = 515
Score = 82.6 bits (195), Expect = 2e-15
Identities = 66/259 (25%), Positives = 127/259 (49%), Gaps = 14/259 (5%)
Frame = +2
Query: 89 RGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTG 268
+GL PP P P++G++L++ K HL SQ+YG++L +R+GS V+V++
Sbjct: 37 KGLKSPPEPWGWPLLGHVLTL------GKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSR 90
Query: 269 IELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGY- 439
++ IR+ V + F+GRPD + T+ + G+ L GP W RR L F
Sbjct: 91 LDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIA 150
Query: 440 ------NSRFMNVYIGEECEALV---QLRLADAGEPILVNQMFHITIVNILWRLVAGKRY 592
+S ++ ++ +E +AL+ Q +A G NQ+ +++ N++ + G+ +
Sbjct: 151 SDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVV-VSVANVIGAMCFGQHF 209
Query: 593 DLXDQRLKKLCSLVMRLFKLVD--MSGGILNFLPFLRHFVPRLIGFTELQXIHNALHQYL 766
+ ++ SLV + V+ SG L+F P LR ++P + + +L
Sbjct: 210 ---PESSDEMLSLVKNTHEFVETASSGNPLDFFPILR-YLPN-PALQRFKAFNQRFLWFL 264
Query: 767 REIIKEHQXNLQLGAPKDV 823
++ ++EH + + +D+
Sbjct: 265 QKTVQEHYQDFDKNSVRDI 283
>DQ022432-1|AAY26399.1| 516|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 2 protein.
Length = 516
Score = 82.6 bits (195), Expect = 2e-15
Identities = 66/259 (25%), Positives = 127/259 (49%), Gaps = 14/259 (5%)
Frame = +2
Query: 89 RGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTG 268
+GL PP P P++G++L++ K HL SQ+YG++L +R+GS V+V++
Sbjct: 37 KGLKSPPEPWGWPLLGHVLTL------GKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSR 90
Query: 269 IELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGY- 439
++ IR+ V + F+GRPD + T+ + G+ L GP W RR L F
Sbjct: 91 LDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIA 150
Query: 440 ------NSRFMNVYIGEECEALV---QLRLADAGEPILVNQMFHITIVNILWRLVAGKRY 592
+S ++ ++ +E +AL+ Q +A G NQ+ +++ N++ + G+ +
Sbjct: 151 SDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVV-VSVANVIGAMCFGQHF 209
Query: 593 DLXDQRLKKLCSLVMRLFKLVD--MSGGILNFLPFLRHFVPRLIGFTELQXIHNALHQYL 766
+ ++ SLV + V+ SG L+F P LR ++P + + +L
Sbjct: 210 ---PESSDEMLSLVKNTHEFVETASSGNPLDFFPILR-YLPN-PALQRFKAFNQRFLWFL 264
Query: 767 REIIKEHQXNLQLGAPKDV 823
++ ++EH + + +D+
Sbjct: 265 QKTVQEHYQDFDKNSVRDI 283
>BC067429-1|AAH67429.1| 516|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 2 protein.
Length = 516
Score = 82.6 bits (195), Expect = 2e-15
Identities = 66/259 (25%), Positives = 127/259 (49%), Gaps = 14/259 (5%)
Frame = +2
Query: 89 RGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTG 268
+GL PP P P++G++L++ K HL SQ+YG++L +R+GS V+V++
Sbjct: 37 KGLKSPPEPWGWPLLGHVLTL------GKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSR 90
Query: 269 IELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGY- 439
++ IR+ V + F+GRPD + T+ + G+ L GP W RR L F
Sbjct: 91 LDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIA 150
Query: 440 ------NSRFMNVYIGEECEALV---QLRLADAGEPILVNQMFHITIVNILWRLVAGKRY 592
+S ++ ++ +E +AL+ Q +A G NQ+ +++ N++ + G+ +
Sbjct: 151 SDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVV-VSVANVIGAMCFGQHF 209
Query: 593 DLXDQRLKKLCSLVMRLFKLVD--MSGGILNFLPFLRHFVPRLIGFTELQXIHNALHQYL 766
+ ++ SLV + V+ SG L+F P LR ++P + + +L
Sbjct: 210 ---PESSDEMLSLVKNTHEFVETASSGNPLDFFPILR-YLPN-PALQRFKAFNQRFLWFL 264
Query: 767 REIIKEHQXNLQLGAPKDV 823
++ ++EH + + +D+
Sbjct: 265 QKTVQEHYQDFDKNSVRDI 283
>BC067428-1|AAH67428.1| 516|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 2 protein.
Length = 516
Score = 82.6 bits (195), Expect = 2e-15
Identities = 66/259 (25%), Positives = 127/259 (49%), Gaps = 14/259 (5%)
Frame = +2
Query: 89 RGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTG 268
+GL PP P P++G++L++ K HL SQ+YG++L +R+GS V+V++
Sbjct: 37 KGLKSPPEPWGWPLLGHVLTL------GKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSR 90
Query: 269 IELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGY- 439
++ IR+ V + F+GRPD + T+ + G+ L GP W RR L F
Sbjct: 91 LDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIA 150
Query: 440 ------NSRFMNVYIGEECEALV---QLRLADAGEPILVNQMFHITIVNILWRLVAGKRY 592
+S ++ ++ +E +AL+ Q +A G NQ+ +++ N++ + G+ +
Sbjct: 151 SDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVV-VSVANVIGAMCFGQHF 209
Query: 593 DLXDQRLKKLCSLVMRLFKLVD--MSGGILNFLPFLRHFVPRLIGFTELQXIHNALHQYL 766
+ ++ SLV + V+ SG L+F P LR ++P + + +L
Sbjct: 210 ---PESSDEMLSLVKNTHEFVETASSGNPLDFFPILR-YLPN-PALQRFKAFNQRFLWFL 264
Query: 767 REIIKEHQXNLQLGAPKDV 823
++ ++EH + + +D+
Sbjct: 265 QKTVQEHYQDFDKNSVRDI 283
>BC067426-1|AAH67426.1| 516|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 2 protein.
Length = 516
Score = 82.6 bits (195), Expect = 2e-15
Identities = 66/259 (25%), Positives = 127/259 (49%), Gaps = 14/259 (5%)
Frame = +2
Query: 89 RGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTG 268
+GL PP P P++G++L++ K HL SQ+YG++L +R+GS V+V++
Sbjct: 37 KGLKSPPEPWGWPLLGHVLTL------GKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSR 90
Query: 269 IELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGY- 439
++ IR+ V + F+GRPD + T+ + G+ L GP W RR L F
Sbjct: 91 LDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIA 150
Query: 440 ------NSRFMNVYIGEECEALV---QLRLADAGEPILVNQMFHITIVNILWRLVAGKRY 592
+S ++ ++ +E +AL+ Q +A G NQ+ +++ N++ + G+ +
Sbjct: 151 SDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVV-VSVANVIGAMCFGQHF 209
Query: 593 DLXDQRLKKLCSLVMRLFKLVD--MSGGILNFLPFLRHFVPRLIGFTELQXIHNALHQYL 766
+ ++ SLV + V+ SG L+F P LR ++P + + +L
Sbjct: 210 ---PESSDEMLSLVKNTHEFVETASSGNPLDFFPILR-YLPN-PALQRFKAFNQRFLWFL 264
Query: 767 REIIKEHQXNLQLGAPKDV 823
++ ++EH + + +D+
Sbjct: 265 QKTVQEHYQDFDKNSVRDI 283
>BC067425-1|AAH67425.1| 516|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 2 protein.
Length = 516
Score = 82.6 bits (195), Expect = 2e-15
Identities = 66/259 (25%), Positives = 127/259 (49%), Gaps = 14/259 (5%)
Frame = +2
Query: 89 RGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTG 268
+GL PP P P++G++L++ K HL SQ+YG++L +R+GS V+V++
Sbjct: 37 KGLKSPPEPWGWPLLGHVLTL------GKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSR 90
Query: 269 IELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGY- 439
++ IR+ V + F+GRPD + T+ + G+ L GP W RR L F
Sbjct: 91 LDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIA 150
Query: 440 ------NSRFMNVYIGEECEALV---QLRLADAGEPILVNQMFHITIVNILWRLVAGKRY 592
+S ++ ++ +E +AL+ Q +A G NQ+ +++ N++ + G+ +
Sbjct: 151 SDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVV-VSVANVIGAMCFGQHF 209
Query: 593 DLXDQRLKKLCSLVMRLFKLVD--MSGGILNFLPFLRHFVPRLIGFTELQXIHNALHQYL 766
+ ++ SLV + V+ SG L+F P LR ++P + + +L
Sbjct: 210 ---PESSDEMLSLVKNTHEFVETASSGNPLDFFPILR-YLPN-PALQRFKAFNQRFLWFL 264
Query: 767 REIIKEHQXNLQLGAPKDV 823
++ ++EH + + +D+
Sbjct: 265 QKTVQEHYQDFDKNSVRDI 283
>BC067424-1|AAH67424.1| 516|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 2 protein.
Length = 516
Score = 82.6 bits (195), Expect = 2e-15
Identities = 66/259 (25%), Positives = 127/259 (49%), Gaps = 14/259 (5%)
Frame = +2
Query: 89 RGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTG 268
+GL PP P P++G++L++ K HL SQ+YG++L +R+GS V+V++
Sbjct: 37 KGLKSPPEPWGWPLLGHVLTL------GKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSR 90
Query: 269 IELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGY- 439
++ IR+ V + F+GRPD + T+ + G+ L GP W RR L F
Sbjct: 91 LDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIA 150
Query: 440 ------NSRFMNVYIGEECEALV---QLRLADAGEPILVNQMFHITIVNILWRLVAGKRY 592
+S ++ ++ +E +AL+ Q +A G NQ+ +++ N++ + G+ +
Sbjct: 151 SDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVV-VSVANVIGAMCFGQHF 209
Query: 593 DLXDQRLKKLCSLVMRLFKLVD--MSGGILNFLPFLRHFVPRLIGFTELQXIHNALHQYL 766
+ ++ SLV + V+ SG L+F P LR ++P + + +L
Sbjct: 210 ---PESSDEMLSLVKNTHEFVETASSGNPLDFFPILR-YLPN-PALQRFKAFNQRFLWFL 264
Query: 767 REIIKEHQXNLQLGAPKDV 823
++ ++EH + + +D+
Sbjct: 265 QKTVQEHYQDFDKNSVRDI 283
>AF253322-2|AAK25728.1| 516|Homo sapiens cytochrome P450 protein.
Length = 516
Score = 82.6 bits (195), Expect = 2e-15
Identities = 66/259 (25%), Positives = 127/259 (49%), Gaps = 14/259 (5%)
Frame = +2
Query: 89 RGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTG 268
+GL PP P P++G++L++ K HL SQ+YG++L +R+GS V+V++
Sbjct: 37 KGLKSPPEPWGWPLLGHVLTL------GKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSR 90
Query: 269 IELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGY- 439
++ IR+ V + F+GRPD + T+ + G+ L GP W RR L F
Sbjct: 91 LDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIA 150
Query: 440 ------NSRFMNVYIGEECEALV---QLRLADAGEPILVNQMFHITIVNILWRLVAGKRY 592
+S ++ ++ +E +AL+ Q +A G NQ+ +++ N++ + G+ +
Sbjct: 151 SDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVV-VSVANVIGAMCFGQHF 209
Query: 593 DLXDQRLKKLCSLVMRLFKLVD--MSGGILNFLPFLRHFVPRLIGFTELQXIHNALHQYL 766
+ ++ SLV + V+ SG L+F P LR ++P + + +L
Sbjct: 210 ---PESSDEMLSLVKNTHEFVETASSGNPLDFFPILR-YLPN-PALQRFKAFNQRFLWFL 264
Query: 767 REIIKEHQXNLQLGAPKDV 823
++ ++EH + + +D+
Sbjct: 265 QKTVQEHYQDFDKNSVRDI 283
>AF182274-1|AAF13599.1| 516|Homo sapiens cytochrome P450-1A2
protein.
Length = 516
Score = 81.4 bits (192), Expect = 4e-15
Identities = 66/259 (25%), Positives = 126/259 (48%), Gaps = 14/259 (5%)
Frame = +2
Query: 89 RGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTG 268
+GL PP P P++G++L++ K HL SQ+YG++L +R+GS V+V++
Sbjct: 37 KGLKSPPEPWGWPLLGHVLTL------GKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSR 90
Query: 269 IELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGY- 439
++ IR+ V + F+GRPD + T+ + G+ L GP W RR L F
Sbjct: 91 LDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIA 150
Query: 440 ------NSRFMNVYIGEECEALV---QLRLADAGEPILVNQMFHITIVNILWRLVAGKRY 592
+S ++ ++ +E AL+ Q +A G NQ+ +++ N++ + G+ +
Sbjct: 151 SDPASSSSCYLEEHVSKEAMALISRLQELMAGPGHFDPYNQVV-VSVANVIGAMCFGQHF 209
Query: 593 DLXDQRLKKLCSLVMRLFKLVD--MSGGILNFLPFLRHFVPRLIGFTELQXIHNALHQYL 766
+ ++ SLV + V+ SG L+F P LR ++P + + +L
Sbjct: 210 ---PESSDEMLSLVKNTHEFVETASSGNPLDFFPILR-YLPN-PALQRFKAFNQRFLWFL 264
Query: 767 REIIKEHQXNLQLGAPKDV 823
++ ++EH + + +D+
Sbjct: 265 QKTVQEHYQDFDKNSVRDI 283
>L00389-1|AAA35738.1| 516|Homo sapiens protein ( Human cytochrome
P-450 4 gene, exon 7, and three Alu repeats in the 3'
flank. ).
Length = 516
Score = 80.2 bits (189), Expect = 8e-15
Identities = 65/259 (25%), Positives = 126/259 (48%), Gaps = 14/259 (5%)
Frame = +2
Query: 89 RGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTG 268
+GL PP P P++G++L++ K HL SQ+YG++L + +GS V+V++
Sbjct: 37 KGLKSPPEPWGWPLLGHVLTL------GKNPHLALSRMSQRYGDVLQISIGSTPVLVLSR 90
Query: 269 IELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGY- 439
++ IR+ V + F+GRPD + T+ + G+ L GP W RR L F
Sbjct: 91 LDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIA 150
Query: 440 ------NSRFMNVYIGEECEALV---QLRLADAGEPILVNQMFHITIVNILWRLVAGKRY 592
+S ++ ++ +E +AL+ Q +A G NQ+ +++ N++ + G+ +
Sbjct: 151 SDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVV-VSVANVIGAMCFGQHF 209
Query: 593 DLXDQRLKKLCSLVMRLFKLVD--MSGGILNFLPFLRHFVPRLIGFTELQXIHNALHQYL 766
+ ++ SLV + V+ SG L+F P LR ++P + + +L
Sbjct: 210 ---PESSDEMLSLVKNTHEFVETASSGNPLDFFPILR-YLPN-PALQRFKAFNQRFLWFL 264
Query: 767 REIIKEHQXNLQLGAPKDV 823
++ ++EH + + +D+
Sbjct: 265 QKTVQEHYQDFDKNSVRDI 283
>BC067427-1|AAH67427.1| 516|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 2 protein.
Length = 516
Score = 79.8 bits (188), Expect = 1e-14
Identities = 65/259 (25%), Positives = 126/259 (48%), Gaps = 14/259 (5%)
Frame = +2
Query: 89 RGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTG 268
+GL PP P P++G++L++ K HL SQ+YG++L +R+ S V+V++
Sbjct: 37 KGLKSPPEPWGWPLLGHVLTL------GKNPHLALSRMSQRYGDVLQIRIDSTPVLVLSR 90
Query: 269 IELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGY- 439
++ IR+ V + F+GRPD + T+ + G+ L GP W RR L F
Sbjct: 91 LDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIA 150
Query: 440 ------NSRFMNVYIGEECEALV---QLRLADAGEPILVNQMFHITIVNILWRLVAGKRY 592
+S ++ ++ +E +AL+ Q +A G NQ+ +++ N++ + G+ +
Sbjct: 151 SDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVV-VSVANVIGAMCFGQHF 209
Query: 593 DLXDQRLKKLCSLVMRLFKLVD--MSGGILNFLPFLRHFVPRLIGFTELQXIHNALHQYL 766
+ ++ SLV + V+ SG L+F P LR ++P + + +L
Sbjct: 210 ---PESSDEMLSLVKNTHEFVETASSGNPLDFFPILR-YLPN-PALQRFKAFNQRFLWFL 264
Query: 767 REIIKEHQXNLQLGAPKDV 823
++ ++EH + + +D+
Sbjct: 265 QKTVQEHYQDFDKNSVRDI 283
>S63426-1|ABB76283.1| 214|Homo sapiens (S)-mephenytoin hydroxylase
associated cytochrome P450 protein.
Length = 214
Score = 79.0 bits (186), Expect = 2e-14
Identities = 56/172 (32%), Positives = 83/172 (48%), Gaps = 3/172 (1%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
P GPTPLPI+GN+L + K ++S+ YG + + G +VV+ G E ++
Sbjct: 30 PSGPTPLPIIGNILQL-----DVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVK 84
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + + E F GR G F K LG++FS+G W RF L L+NFG R +
Sbjct: 85 EALIDHGEEFSGR--GSFPVAEKVNKGLGILFSNGKRWKEIWRFCLMTLRNFGMGKRSIE 142
Query: 458 VYIGEECEALV-QLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQR 610
+ EE LV +LR +A P + N+ ++ R+D DQR
Sbjct: 143 DRVQEEARCLVEELRKTNA-SPCDPTFILGCAPCNVTCSVIFHDRFDYKDQR 193
>AM233520-1|CAJ80723.1| 189|Homo sapiens cytochrome P450 1A1
protein.
Length = 189
Score = 78.6 bits (185), Expect = 3e-14
Identities = 47/143 (32%), Positives = 78/143 (54%), Gaps = 9/143 (6%)
Frame = +2
Query: 89 RGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTG 268
+GL PPGP P++G++L++ K HL SQ+YG++L +R+GS VVV++G
Sbjct: 35 KGLKNPPGPWGWPLIGHMLTL------GKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSG 88
Query: 269 IELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGY- 439
++ IR+ V + F+GRPD + +T+ S G+ + GP W RR LK+F
Sbjct: 89 LDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIA 148
Query: 440 ------NSRFMNVYIGEECEALV 490
S ++ ++ +E E L+
Sbjct: 149 SDPASSTSCYLEEHVSKEAEVLI 171
>AM233519-1|CAJ80722.1| 189|Homo sapiens cytochrome P450 1A1
protein.
Length = 189
Score = 78.6 bits (185), Expect = 3e-14
Identities = 47/143 (32%), Positives = 78/143 (54%), Gaps = 9/143 (6%)
Frame = +2
Query: 89 RGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTG 268
+GL PPGP P++G++L++ K HL SQ+YG++L +R+GS VVV++G
Sbjct: 35 KGLKNPPGPWGWPLIGHMLTL------GKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSG 88
Query: 269 IELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGY- 439
++ IR+ V + F+GRPD + +T+ S G+ + GP W RR LK+F
Sbjct: 89 LDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIA 148
Query: 440 ------NSRFMNVYIGEECEALV 490
S ++ ++ +E E L+
Sbjct: 149 SDPASSTSCYLEEHVSKEAEVLI 171
>X13929-1|CAA32117.1| 448|Homo sapiens P-450 IIA3 protein (1 is 3rd
base in codon) protein.
Length = 448
Score = 77.4 bits (182), Expect = 6e-14
Identities = 61/213 (28%), Positives = 98/213 (46%), Gaps = 5/213 (2%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFS 376
S++YG + + LG VVV+ G + +RE V E F GR G T K G+VFS
Sbjct: 16 SERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGR--GEQATFDWVFKGYGVVFS 73
Query: 377 DGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIV 556
+G + RRF + L++FG R + I EE L+ G I T+
Sbjct: 74 NGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVS 133
Query: 557 NILWRLVAGKRYDLXDQRLKKLCSLVMRLFKLVDMSGGIL--NFLPFLRHFV-PRLIGFT 727
N++ +V G R+D D+ L +++ +F+ S G L F ++H P+ F
Sbjct: 134 NVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQ 193
Query: 728 ELQXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
LQ L ++ + ++ +Q L +P+D I
Sbjct: 194 LLQ----GLEDFIAKKVEHNQRTLDPNSPRDFI 222
>L07093-1|AAA36660.1| 468|Homo sapiens cytochrome P450 protein.
Length = 468
Score = 77.4 bits (182), Expect = 6e-14
Identities = 59/216 (27%), Positives = 95/216 (43%), Gaps = 5/216 (2%)
Frame = +2
Query: 194 QSWSQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGL 367
Q S+ YG + L G +VV+ G E+++E + E F GR G F + G+
Sbjct: 33 QQLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGR--GHFPLAERANRGFGI 90
Query: 368 VFSDGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHI 547
VFS+G W RRF L L+NFG R + + EE LV+ P +
Sbjct: 91 VFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC 150
Query: 548 TIVNILWRLVAGKRYDLXDQRLKKLCSLVMRLFKLVDMSG-GILNFLPFLRHFVPRLIGF 724
N++ ++ KR+D DQ+ L + ++V I N P + + P
Sbjct: 151 APCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPG---- 206
Query: 725 TELQXIHNA--LHQYLREIIKEHQXNLQLGAPKDVI 826
T + + N + + E +KEHQ ++ + P+D I
Sbjct: 207 THNKLLKNLAFMESDILEKVKEHQESMDINNPRDFI 242
>BC070317-1|AAH70317.1| 162|Homo sapiens CYP2C9 protein protein.
Length = 162
Score = 77.4 bits (182), Expect = 6e-14
Identities = 50/140 (35%), Positives = 70/140 (50%), Gaps = 3/140 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLP++GN+L + + +L S+ YG + L G +VV+ G E ++
Sbjct: 30 PPGPTPLPVIGNILQIGIKDISKSLTNL-----SKVYGPVFTLYFGLKPIVVLHGYEAVK 84
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + E F GR G F + G+VFS+G W RRF L L+NFG R +
Sbjct: 85 EALIDLGEEFSGR--GIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIE 142
Query: 458 VYIGEECEALV-QLRLADAG 514
+ EE LV +LR G
Sbjct: 143 DCVQEEARCLVEELRKTKGG 162
>BC020754-1|AAH20754.1| 162|Homo sapiens CYP2C9 protein protein.
Length = 162
Score = 77.4 bits (182), Expect = 6e-14
Identities = 50/140 (35%), Positives = 70/140 (50%), Gaps = 3/140 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLP++GN+L + + +L S+ YG + L G +VV+ G E ++
Sbjct: 30 PPGPTPLPVIGNILQIGIKDISKSLTNL-----SKVYGPVFTLYFGLKPIVVLHGYEAVK 84
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + E F GR G F + G+VFS+G W RRF L L+NFG R +
Sbjct: 85 EALIDLGEEFSGR--GIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIE 142
Query: 458 VYIGEECEALV-QLRLADAG 514
+ EE LV +LR G
Sbjct: 143 DRVQEEARCLVEELRKTKGG 162
>L39098-1|AAL31347.1| 160|Homo sapiens S-mephenytoin 4-hydroxylase
protein.
Length = 160
Score = 77.0 bits (181), Expect = 8e-14
Identities = 47/132 (35%), Positives = 68/132 (51%), Gaps = 2/132 (1%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIR 283
PPGPTPLP++GN+L + + +L S+ YG + L G +VV+ G E+++
Sbjct: 30 PPGPTPLPVIGNILQIDIKDVSKSLTNL-----SKIYGPVFTLYFGLERMVVLHGYEVVK 84
Query: 284 E--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMN 457
E + E F GR G F + G+VFS+G W RRF L L+NFG R +
Sbjct: 85 EALIDLGEEFSGR--GHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIE 142
Query: 458 VYIGEECEALVQ 493
+ EE LV+
Sbjct: 143 DRVQEEARCLVE 154
>BC104909-1|AAI04910.1| 501|Homo sapiens cytochrome P450, family 2,
subfamily R, polypeptide 1 protein.
Length = 501
Score = 76.2 bits (179), Expect = 1e-13
Identities = 56/209 (26%), Positives = 91/209 (43%), Gaps = 4/209 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
++ R + +PPGP LP +GN+ S+ S + H+ + SQ YG + L LG I+ VV
Sbjct: 32 KQRRPMGFPPGPPGLPFIGNIYSLAASS---ELPHVYMRKQSQVYGEIFSLDLGGISTVV 88
Query: 260 VTGIELIRE--VSNREVFEGRPD-GFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKN 430
+ G ++++E V E+F RP F M G L + G W RR + +
Sbjct: 89 LNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRG--WVDHRRLAVNSFRY 146
Query: 431 FGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQR 610
FGY + I EE + G P Q+ + NI ++ G+R+ D
Sbjct: 147 FGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTD 206
Query: 611 LKKLCSLVMRLFKLVDMSGGIL-NFLPFL 694
+ + L +L + L N P++
Sbjct: 207 FQHMIELFSENVELAASASVFLYNAFPWI 235
>BC104907-1|AAI04908.1| 501|Homo sapiens cytochrome P450, family 2,
subfamily R, polypeptide 1 protein.
Length = 501
Score = 76.2 bits (179), Expect = 1e-13
Identities = 56/209 (26%), Positives = 91/209 (43%), Gaps = 4/209 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
++ R + +PPGP LP +GN+ S+ S + H+ + SQ YG + L LG I+ VV
Sbjct: 32 KQRRPMGFPPGPPGLPFIGNIYSLAASS---ELPHVYMRKQSQVYGEIFSLDLGGISTVV 88
Query: 260 VTGIELIRE--VSNREVFEGRPD-GFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKN 430
+ G ++++E V E+F RP F M G L + G W RR + +
Sbjct: 89 LNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRG--WVDHRRLAVNSFRY 146
Query: 431 FGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQR 610
FGY + I EE + G P Q+ + NI ++ G+R+ D
Sbjct: 147 FGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTD 206
Query: 611 LKKLCSLVMRLFKLVDMSGGIL-NFLPFL 694
+ + L +L + L N P++
Sbjct: 207 FQHMIELFSENVELAASASVFLYNAFPWI 235
>AY323817-1|AAQ23114.1| 501|Homo sapiens cytochrome P450 2R1
protein.
Length = 501
Score = 76.2 bits (179), Expect = 1e-13
Identities = 56/209 (26%), Positives = 91/209 (43%), Gaps = 4/209 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
++ R + +PPGP LP +GN+ S+ S + H+ + SQ YG + L LG I+ VV
Sbjct: 32 KQRRPMGFPPGPPGLPFIGNIYSLAASS---ELPHVYMRKQSQVYGEIFSLDLGGISTVV 88
Query: 260 VTGIELIRE--VSNREVFEGRPD-GFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKN 430
+ G ++++E V E+F RP F M G L + G W RR + +
Sbjct: 89 LNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRG--WVDHRRLAVNSFRY 146
Query: 431 FGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQR 610
FGY + I EE + G P Q+ + NI ++ G+R+ D
Sbjct: 147 FGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTD 206
Query: 611 LKKLCSLVMRLFKLVDMSGGIL-NFLPFL 694
+ + L +L + L N P++
Sbjct: 207 FQHMIELFSENVELAASASVFLYNAFPWI 235
>AB209492-1|BAD92729.1| 566|Homo sapiens Debrisoquine 4-hydroxylase
mutant allele variant protein.
Length = 566
Score = 63.3 bits (147), Expect(2) = 9e-13
Identities = 54/202 (26%), Positives = 90/202 (44%), Gaps = 7/202 (3%)
Frame = +2
Query: 206 QKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSD 379
+++G++ L+L VVV+ G+ +RE V+ E RP + FG + VF
Sbjct: 133 RRFGDVFSLQLAWTPVVVLNGLAAVREAMVTRGEDTADRPPVPITQILGFGPRSQGVFLA 192
Query: 380 --GPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITI 553
GP W RRF + L+N G + + ++ EE L A+ + +
Sbjct: 193 RYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLC-AAFANHSDAPFAPTVSWTKP 251
Query: 554 VNILWRLVAGKRYDLXDQRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGF 724
N++ L G+R++ D R +L L K + SG +LN +P L H +P L G
Sbjct: 252 SNVIASLTCGRRFEYDDPRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG- 307
Query: 725 TELQXIHNALHQYLREIIKEHQ 790
++ A L E++ EH+
Sbjct: 308 -KVLRFQKAFLTQLDELLTEHR 328
Score = 30.3 bits (65), Expect(2) = 9e-13
Identities = 15/32 (46%), Positives = 20/32 (62%), Gaps = 1/32 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKF 172
RR R Y PGP PLP +GNLL V +++ +
Sbjct: 62 RRQRWAARYSPGPLPLPGLGNLLHVDFQNTPY 93
>BC033691-1|AAH33691.1| 504|Homo sapiens cytochrome P450, family 2,
subfamily S, polypeptide 1 protein.
Length = 504
Score = 72.9 bits (171), Expect = 1e-12
Identities = 67/247 (27%), Positives = 106/247 (42%), Gaps = 6/247 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSIN-VVVVTGIELI 280
PPGPTPLP++GNLL + R + + + S+KYG + + LG VVV+ G E +
Sbjct: 33 PPGPTPLPLLGNLLQL----RPGALYSGLMRL-SKKYGPVFTIYLGPWRPVVVLVGQEAV 87
Query: 281 REV--SNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFM 454
RE E F GR G + G+ FS+G W + R+F + L++ G R
Sbjct: 88 REALGGQAEEFSGR--GTVAMLEGTFDGHGVFFSNGERWRQLRKFTMLALRDLGMGKREG 145
Query: 455 NVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLV 634
I E LV+ G P + + N++ L+ G R+ D+ + +
Sbjct: 146 EELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAA 205
Query: 635 MRLFKLVDMSGGILNFLPFLRHFVPRLIGFTELQXIH--NALHQYLREIIKEHQXNLQLG 808
V GG F+ L G Q +H + L + +++HQ NL
Sbjct: 206 GGTLLGVSSQGG--QTYEMFSWFLRPLPG-PHKQLLHHVSTLAAFTVRQVQQHQGNLDAS 262
Query: 809 AP-KDVI 826
P +D++
Sbjct: 263 GPARDLV 269
>AY358603-1|AAQ88966.1| 504|Homo sapiens Cytochrome p450 protein.
Length = 504
Score = 72.9 bits (171), Expect = 1e-12
Identities = 67/247 (27%), Positives = 106/247 (42%), Gaps = 6/247 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSIN-VVVVTGIELI 280
PPGPTPLP++GNLL + R + + + S+KYG + + LG VVV+ G E +
Sbjct: 33 PPGPTPLPLLGNLLQL----RPGALYSGLMRL-SKKYGPVFTIYLGPWRPVVVLVGQEAV 87
Query: 281 REV--SNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFM 454
RE E F GR G + G+ FS+G W + R+F + L++ G R
Sbjct: 88 REALGGQAEEFSGR--GTVAMLEGTFDGHGVFFSNGERWRQLRKFTMLALRDLGMGKREG 145
Query: 455 NVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLV 634
I E LV+ G P + + N++ L+ G R+ D+ + +
Sbjct: 146 EELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAA 205
Query: 635 MRLFKLVDMSGGILNFLPFLRHFVPRLIGFTELQXIH--NALHQYLREIIKEHQXNLQLG 808
V GG F+ L G Q +H + L + +++HQ NL
Sbjct: 206 GGTLLGVSSQGG--QTYEMFSWFLRPLPG-PHKQLLHHVSTLAAFTVRQVQQHQGNLDAS 262
Query: 809 AP-KDVI 826
P +D++
Sbjct: 263 GPARDLV 269
>AK027605-1|BAB55227.1| 564|Homo sapiens protein ( Homo sapiens
cDNA FLJ14699 fis, clone NT2RP2006571, moderately
similar to CYTOCHROME P450 2G1 (EC 1.14.14.1). ).
Length = 564
Score = 72.9 bits (171), Expect = 1e-12
Identities = 67/247 (27%), Positives = 106/247 (42%), Gaps = 6/247 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSIN-VVVVTGIELI 280
PPGPTPLP++GNLL + R + + + S+KYG + + LG VVV+ G E +
Sbjct: 33 PPGPTPLPLLGNLLQL----RPGALYSGLMRL-SKKYGPVFTIYLGPWRPVVVLVGQEAV 87
Query: 281 REV--SNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFM 454
RE E F GR G + G+ FS+G W + R+F + L++ G R
Sbjct: 88 REALGGQAEEFSGR--GTVAMLEGTFDGHGVFFSNGERWRQLRKFTMLALRDLGMGKREG 145
Query: 455 NVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLV 634
I E LV+ G P + + N++ L+ G R+ D+ + +
Sbjct: 146 EELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAA 205
Query: 635 MRLFKLVDMSGGILNFLPFLRHFVPRLIGFTELQXIH--NALHQYLREIIKEHQXNLQLG 808
V GG F+ L G Q +H + L + +++HQ NL
Sbjct: 206 GGTLLGVSSQGG--QTYEMFSWFLRPLPG-PHKQLLHHVSTLAAFTVRQVQQHQGNLDAS 262
Query: 809 AP-KDVI 826
P +D++
Sbjct: 263 GPARDLV 269
>AF335278-1|AAK13498.1| 504|Homo sapiens cytochrome P450 2S1
protein.
Length = 504
Score = 72.9 bits (171), Expect = 1e-12
Identities = 67/247 (27%), Positives = 106/247 (42%), Gaps = 6/247 (2%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSIN-VVVVTGIELI 280
PPGPTPLP++GNLL + R + + + S+KYG + + LG VVV+ G E +
Sbjct: 33 PPGPTPLPLLGNLLQL----RPGALYSGLMRL-SKKYGPVFTIYLGPWRPVVVLVGQEAV 87
Query: 281 REV--SNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFM 454
RE E F GR G + G+ FS+G W + R+F + L++ G R
Sbjct: 88 REALGGQAEEFSGR--GTVAMLEGTFDGHGVFFSNGERWRQLRKFTMLALRDLGMGKREG 145
Query: 455 NVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLV 634
I E LV+ G P + + N++ L+ G R+ D+ + +
Sbjct: 146 EELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAA 205
Query: 635 MRLFKLVDMSGGILNFLPFLRHFVPRLIGFTELQXIH--NALHQYLREIIKEHQXNLQLG 808
V GG F+ L G Q +H + L + +++HQ NL
Sbjct: 206 GGTLLGVSSQGG--QTYEMFSWFLRPLPG-PHKQLLHHVSTLAAFTVRQVQQHQGNLDAS 262
Query: 809 AP-KDVI 826
P +D++
Sbjct: 263 GPARDLV 269
>BC025761-1|AAH25761.2| 490|Homo sapiens cytochrome P450, family 2,
subfamily W, polypeptide 1 protein.
Length = 490
Score = 68.9 bits (161), Expect = 2e-11
Identities = 55/202 (27%), Positives = 90/202 (44%), Gaps = 4/202 (1%)
Frame = +2
Query: 101 YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELI 280
+PPGP PLP+VGNL + + L S++YG + + LG VV+TG E +
Sbjct: 31 WPPGPRPLPLVGNLHLLRLSQQDRSLMEL-----SERYGPVFTVHLGRQKTVVLTGFEAV 85
Query: 281 REV---SNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRF 451
+E +E+ + P F ++ G G+ FS G W R+F ++ L + G
Sbjct: 86 KEALAGPGQELADRPPIAIFQLIQRGG---GIFFSSGARWRAARQFTVRALHSLGVGREP 142
Query: 452 MNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSL 631
+ I +E + L G P + + NI + L+ G+R+D D L L
Sbjct: 143 VADKILQELKCLSGQLDGYRGRPFPL-ALLGWAPSNITFALLFGRRFDYRDPVFVSLLGL 201
Query: 632 VMRLFKLVDMSG-GILNFLPFL 694
+ + L+ G + N P+L
Sbjct: 202 IDEVMVLLGSPGLQLFNVYPWL 223
>U56438-1|AAC50809.1| 543|Homo sapiens dioxin-inducible cytochrome
P450 protein.
Length = 543
Score = 63.7 bits (148), Expect = 8e-10
Identities = 58/259 (22%), Positives = 117/259 (45%), Gaps = 10/259 (3%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
RR + PPGP P++GN +V + HL + +++YG++ +RLGS +VV
Sbjct: 43 RRRQLRSAPPGPFAWPLIGNAAAV------GQAAHLSFARLARRYGDVFQIRLGSCPIVV 96
Query: 260 VTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNF 433
+ G I + V F RP + + S G+ + W RR ++NF
Sbjct: 97 LNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHY-SEHWKVQRRAAHSMMRNF 155
Query: 434 ----GYNSRFMNVYIGEECEALVQLRLADAGEPILVN--QMFHITIVNILWRLVAGKRYD 595
+ + + ++ E LV L + + + ++ + + + N++ + G RY
Sbjct: 156 FTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYS 215
Query: 596 LXDQRLKKLCSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIGFTELQXIHNALHQYLRE 772
D ++L S + V +G +++ +P+L++F P F E + ++ ++ +
Sbjct: 216 HDDPEFRELLSHNEEFGRTVG-AGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILD 274
Query: 773 IIKEHQXNLQLG-APKDVI 826
H +L+ G AP+D++
Sbjct: 275 KFLRHCESLRPGAAPRDMM 293
>U03688-1|AAA19567.1| 543|Homo sapiens cytochrome P450 protein.
Length = 543
Score = 63.7 bits (148), Expect = 8e-10
Identities = 58/259 (22%), Positives = 117/259 (45%), Gaps = 10/259 (3%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
RR + PPGP P++GN +V + HL + +++YG++ +RLGS +VV
Sbjct: 43 RRRQLRSAPPGPFAWPLIGNAAAV------GQAAHLSFARLARRYGDVFQIRLGSCPIVV 96
Query: 260 VTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNF 433
+ G I + V F RP + + S G+ + W RR ++NF
Sbjct: 97 LNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHY-SEHWKVQRRAAHSMMRNF 155
Query: 434 ----GYNSRFMNVYIGEECEALVQLRLADAGEPILVN--QMFHITIVNILWRLVAGKRYD 595
+ + + ++ E LV L + + + ++ + + + N++ + G RY
Sbjct: 156 FTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYS 215
Query: 596 LXDQRLKKLCSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIGFTELQXIHNALHQYLRE 772
D ++L S + V +G +++ +P+L++F P F E + ++ ++ +
Sbjct: 216 HDDPEFRELLSHNEEFGRTVG-AGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILD 274
Query: 773 IIKEHQXNLQLG-APKDVI 826
H +L+ G AP+D++
Sbjct: 275 KFLRHCESLRPGAAPRDMM 293
>BT019979-1|AAV38782.1| 543|Homo sapiens cytochrome P450, family 1,
subfamily B, polypeptide 1 protein.
Length = 543
Score = 63.7 bits (148), Expect = 8e-10
Identities = 58/259 (22%), Positives = 117/259 (45%), Gaps = 10/259 (3%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
RR + PPGP P++GN +V + HL + +++YG++ +RLGS +VV
Sbjct: 43 RRRQLRSAPPGPFAWPLIGNAAAV------GQAAHLSFARLARRYGDVFQIRLGSCPIVV 96
Query: 260 VTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNF 433
+ G I + V F RP + + S G+ + W RR ++NF
Sbjct: 97 LNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHY-SEHWKVQRRAAHSMMRNF 155
Query: 434 ----GYNSRFMNVYIGEECEALVQLRLADAGEPILVN--QMFHITIVNILWRLVAGKRYD 595
+ + + ++ E LV L + + + ++ + + + N++ + G RY
Sbjct: 156 FTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYS 215
Query: 596 LXDQRLKKLCSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIGFTELQXIHNALHQYLRE 772
D ++L S + V +G +++ +P+L++F P F E + ++ ++ +
Sbjct: 216 HDDPEFRELLSHNEEFGRTVG-AGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILD 274
Query: 773 IIKEHQXNLQLG-APKDVI 826
H +L+ G AP+D++
Sbjct: 275 KFLRHCESLRPGAAPRDMM 293
>BC012049-1|AAH12049.1| 543|Homo sapiens cytochrome P450, family 1,
subfamily B, polypeptide 1 protein.
Length = 543
Score = 63.7 bits (148), Expect = 8e-10
Identities = 58/259 (22%), Positives = 117/259 (45%), Gaps = 10/259 (3%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
RR + PPGP P++GN +V + HL + +++YG++ +RLGS +VV
Sbjct: 43 RRRQLRSAPPGPFAWPLIGNAAAV------GQAAHLSFARLARRYGDVFQIRLGSCPIVV 96
Query: 260 VTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNF 433
+ G I + V F RP + + S G+ + W RR ++NF
Sbjct: 97 LNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHY-SEHWKVQRRAAHSMMRNF 155
Query: 434 ----GYNSRFMNVYIGEECEALVQLRLADAGEPILVN--QMFHITIVNILWRLVAGKRYD 595
+ + + ++ E LV L + + + ++ + + + N++ + G RY
Sbjct: 156 FTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYS 215
Query: 596 LXDQRLKKLCSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIGFTELQXIHNALHQYLRE 772
D ++L S + V +G +++ +P+L++F P F E + ++ ++ +
Sbjct: 216 HDDPEFRELLSHNEEFGRTVG-AGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILD 274
Query: 773 IIKEHQXNLQLG-APKDVI 826
H +L+ G AP+D++
Sbjct: 275 KFLRHCESLRPGAAPRDMM 293
>AY393998-1|AAQ87875.1| 543|Homo sapiens cytochrome P450, family 1,
subfamily B, polypeptide 1 protein.
Length = 543
Score = 63.7 bits (148), Expect = 8e-10
Identities = 58/259 (22%), Positives = 117/259 (45%), Gaps = 10/259 (3%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
RR + PPGP P++GN +V + HL + +++YG++ +RLGS +VV
Sbjct: 43 RRRQLRSAPPGPFAWPLIGNAAAV------GQAAHLSFARLARRYGDVFQIRLGSCPIVV 96
Query: 260 VTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNF 433
+ G I + V F RP + + S G+ + W RR ++NF
Sbjct: 97 LNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHY-SEHWKVQRRAAHSMMRNF 155
Query: 434 ----GYNSRFMNVYIGEECEALVQLRLADAGEPILVN--QMFHITIVNILWRLVAGKRYD 595
+ + + ++ E LV L + + + ++ + + + N++ + G RY
Sbjct: 156 FTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYS 215
Query: 596 LXDQRLKKLCSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIGFTELQXIHNALHQYLRE 772
D ++L S + V +G +++ +P+L++F P F E + ++ ++ +
Sbjct: 216 HDDPEFRELLSHNEEFGRTVG-AGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILD 274
Query: 773 IIKEHQXNLQLG-APKDVI 826
H +L+ G AP+D++
Sbjct: 275 KFLRHCESLRPGAAPRDMM 293
>AF450132-1|AAM50512.1| 543|Homo sapiens cytochrome P450 CYP1B1
protein.
Length = 543
Score = 63.7 bits (148), Expect = 8e-10
Identities = 58/259 (22%), Positives = 117/259 (45%), Gaps = 10/259 (3%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
RR + PPGP P++GN +V + HL + +++YG++ +RLGS +VV
Sbjct: 43 RRRQLRSAPPGPFAWPLIGNAAAV------GQAAHLSFARLARRYGDVFQIRLGSCPIVV 96
Query: 260 VTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNF 433
+ G I + V F RP + + S G+ + W RR ++NF
Sbjct: 97 LNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHY-SEHWKVQRRAAHSMMRNF 155
Query: 434 ----GYNSRFMNVYIGEECEALVQLRLADAGEPILVN--QMFHITIVNILWRLVAGKRYD 595
+ + + ++ E LV L + + + ++ + + + N++ + G RY
Sbjct: 156 FTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYS 215
Query: 596 LXDQRLKKLCSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIGFTELQXIHNALHQYLRE 772
D ++L S + V +G +++ +P+L++F P F E + ++ ++ +
Sbjct: 216 HDDPEFRELLSHNEEFGRTVG-AGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILD 274
Query: 773 IIKEHQXNLQLG-APKDVI 826
H +L+ G AP+D++
Sbjct: 275 KFLRHCESLRPGAAPRDMM 293
>AC009229-2|AAY15039.1| 543|Homo sapiens unknown protein.
Length = 543
Score = 63.7 bits (148), Expect = 8e-10
Identities = 58/259 (22%), Positives = 117/259 (45%), Gaps = 10/259 (3%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
RR + PPGP P++GN +V + HL + +++YG++ +RLGS +VV
Sbjct: 43 RRRQLRSAPPGPFAWPLIGNAAAV------GQAAHLSFARLARRYGDVFQIRLGSCPIVV 96
Query: 260 VTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNF 433
+ G I + V F RP + + S G+ + W RR ++NF
Sbjct: 97 LNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHY-SEHWKVQRRAAHSMMRNF 155
Query: 434 ----GYNSRFMNVYIGEECEALVQLRLADAGEPILVN--QMFHITIVNILWRLVAGKRYD 595
+ + + ++ E LV L + + + ++ + + + N++ + G RY
Sbjct: 156 FTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYS 215
Query: 596 LXDQRLKKLCSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIGFTELQXIHNALHQYLRE 772
D ++L S + V +G +++ +P+L++F P F E + ++ ++ +
Sbjct: 216 HDDPEFRELLSHNEEFGRTVG-AGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILD 274
Query: 773 IIKEHQXNLQLG-APKDVI 826
H +L+ G AP+D++
Sbjct: 275 KFLRHCESLRPGAAPRDMM 293
>M21940-1|AAA52159.1| 383|Homo sapiens CYP2C protein.
Length = 383
Score = 63.3 bits (147), Expect = 1e-09
Identities = 43/159 (27%), Positives = 71/159 (44%), Gaps = 4/159 (2%)
Frame = +2
Query: 362 GLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMF 541
G+VFS+G W RRF L L+NFG R + + EE LV+ P +
Sbjct: 4 GIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFIL 63
Query: 542 HITIVNILWRLVAGKRYDLXDQRLKKLCSLVMRLFKLVDMSGGIL--NFLPFLRHFVPRL 715
N++ ++ KR+D DQ+ L + K++ + NF P + +F
Sbjct: 64 GCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPG-- 121
Query: 716 IGFTELQXIHNA--LHQYLREIIKEHQXNLQLGAPKDVI 826
T + + N + Y+ E +KEHQ ++ + P+D I
Sbjct: 122 ---THNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFI 157
>DQ359216-1|ABC95161.1| 347|Homo sapiens dioxin-inducible
cytochrome P450 protein.
Length = 347
Score = 62.9 bits (146), Expect = 1e-09
Identities = 58/257 (22%), Positives = 115/257 (44%), Gaps = 10/257 (3%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
RR + PPGP P++GN +V + HL + +++YG++ +RLGS +VV
Sbjct: 43 RRRQLRSAPPGPFAWPLIGNAAAV------GQAAHLSFARLARRYGDVFQIRLGSCPIVV 96
Query: 260 VTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNF 433
+ G I + V F RP + + S G+ + W RR ++NF
Sbjct: 97 LNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHY-SEHWKVQRRAAHSMMRNF 155
Query: 434 ----GYNSRFMNVYIGEECEALVQLRLADAGEPILVN--QMFHITIVNILWRLVAGKRYD 595
+ + + ++ E LV L + + + ++ + + + N++ + G RY
Sbjct: 156 FTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYS 215
Query: 596 LXDQRLKKLCSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIGFTELQXIHNALHQYLRE 772
D ++L S + V +G +++ +P+L++F P F E + ++ ++ +
Sbjct: 216 HDDPEFRELLSHNEEFGRTVG-AGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILD 274
Query: 773 IIKEHQXNLQLG-APKD 820
H +L+ G AP+D
Sbjct: 275 KFLRHCESLRPGAAPRD 291
>BT020001-1|AAV38804.1| 543|Homo sapiens cytochrome P450, family 1,
subfamily B, polypeptide 1 protein.
Length = 543
Score = 62.9 bits (146), Expect = 1e-09
Identities = 58/259 (22%), Positives = 117/259 (45%), Gaps = 10/259 (3%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
RR + PPGP P++GN +V + HL + +++YG++ +RLGS +VV
Sbjct: 43 RRRQLRSAPPGPFAWPLIGNAAAV------GQAAHLSFARLARRYGDVFQIRLGSCPIVV 96
Query: 260 VTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNF 433
+ G I + V F RP + + S G+ + W RR ++NF
Sbjct: 97 LNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHY-SEHWKVQRRAAHSMMRNF 155
Query: 434 ----GYNSRFMNVYIGEECEALVQLRLADAGEPILVN--QMFHITIVNILWRLVAGKRYD 595
+ + + ++ E LV L + + + ++ + + + N++ + G RY
Sbjct: 156 FTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVAMANVMSAVCFGCRYS 215
Query: 596 LXDQRLKKLCSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIGFTELQXIHNALHQYLRE 772
D ++L S + V +G +++ +P+L++F P F E + ++ ++ +
Sbjct: 216 HDDPEFRELLSHNEEFGRTVG-AGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSSFILD 274
Query: 773 IIKEHQXNLQLG-APKDVI 826
H +L+ G AP+D++
Sbjct: 275 KFLRHCESLRPGAAPRDMM 293
>M33189-1|AAA35737.1| 500|Homo sapiens protein ( Human debrisoquine
4-hydroxylase mutant allele (CYP2D6-MA1) gene, complete
cds. ).
Length = 500
Score = 62.5 bits (145), Expect = 2e-09
Identities = 70/252 (27%), Positives = 110/252 (43%), Gaps = 15/252 (5%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R Y PGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYSPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRP-----DGFFYTMRSFGKKLGLVFSDGPTWHRTRR--- 406
V+ G+ +RE V+ E RP + RS GK+ G+ G W R R
Sbjct: 80 VLNGLAAVREAMVTRGEDTADRPPVPITQILGFGPRSQGKQRGV---PGALWARVARAEA 136
Query: 407 FVLKYLKNFGYNSRFMNVYIGEECEALVQLRLAD-AGEPILVNQMFHITIVNILWRLVAG 583
+ +L G +G+ L RL P N + + N++ L G
Sbjct: 137 LLRLHLAQLGPGQEVAGA-VGDRGGRLPLCRLRQPLRRPFRPNGLLDKAVSNVIASLTCG 195
Query: 584 KRYDLXDQRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQXIHNAL 754
+R++ D R +L L K + SG +LN +P L H +P L G ++ A
Sbjct: 196 RRFEYDDPRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAF 250
Query: 755 HQYLREIIKEHQ 790
L E++ EH+
Sbjct: 251 LTQLDELLTEHR 262
>M24499-1|AAA36403.1| 373|Homo sapiens cytochrome P450db1 protein.
Length = 373
Score = 60.9 bits (141), Expect = 5e-09
Identities = 39/140 (27%), Positives = 63/140 (45%), Gaps = 3/140 (2%)
Frame = +2
Query: 380 GPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVN 559
GP W RRF + L+N G + + ++ EE L +G P N + + N
Sbjct: 1 GPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSN 60
Query: 560 ILWRLVAGKRYDLXDQRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFTE 730
++ L G+R++ D R +L L K + SG +LN +P L H +P L G +
Sbjct: 61 VIASLTCGRRFEYDDPRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG--K 115
Query: 731 LQXIHNALHQYLREIIKEHQ 790
+ A L E++ EH+
Sbjct: 116 VLRFQKAFLTQLDELLTEHR 135
>AK000366-1|BAA91114.1| 408|Homo sapiens protein ( Homo sapiens
cDNA FLJ20359 fis, clone HEP16626. ).
Length = 408
Score = 52.4 bits (120), Expect = 2e-06
Identities = 43/168 (25%), Positives = 74/168 (44%), Gaps = 4/168 (2%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIREV---SNREVFEGRPDGFFYTMRSFGKKLGLVF 373
S++YG + + LG VV+TG E ++E +E+ + P F ++ G G+ F
Sbjct: 4 SERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGG---GIFF 60
Query: 374 SDGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITI 553
S G W R+F ++ L + G + I +E + L G P + +
Sbjct: 61 SSGARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPFPL-ALLGWAP 119
Query: 554 VNILWRLVAGKRYDLXDQRLKKLCSLVMRLFKLVDMSG-GILNFLPFL 694
NI + L+ G+R+D D L L+ + L+ G + N P+L
Sbjct: 120 SNITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVHPWL 167
>M63871-1|AAA59984.1| 508|Homo sapiens CYP17 protein.
Length = 508
Score = 50.8 bits (116), Expect = 6e-06
Identities = 45/181 (24%), Positives = 77/181 (42%), Gaps = 3/181 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
RR G YP LP+VG+L + R H+ ++ +KYG + +R+G+ V+
Sbjct: 20 RRWPGAKYPKSLLSLPLVGSLPFL---PRHGHMHNNFFKL-QKKYGPIYSVRMGTKTTVI 75
Query: 260 VTGIELIREV--SNREVFEGRPDGFFYTMRSFGKKLGLVFSD-GPTWHRTRRFVLKYLKN 430
V +L +EV + F GRP + S +K G+ F+D G W RR +
Sbjct: 76 VGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRK-GIAFADSGAHWQLHRRLAMATFAL 134
Query: 431 FGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQR 610
F + + I +E L + G+ I ++ + + N++ + Y D
Sbjct: 135 FKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPE 194
Query: 611 L 613
L
Sbjct: 195 L 195
>M19489-1|AAA36405.1| 508|Homo sapiens CYP17 protein.
Length = 508
Score = 50.8 bits (116), Expect = 6e-06
Identities = 45/181 (24%), Positives = 77/181 (42%), Gaps = 3/181 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
RR G YP LP+VG+L + R H+ ++ +KYG + +R+G+ V+
Sbjct: 20 RRWPGAKYPKSLLSLPLVGSLPFL---PRHGHMHNNFFKL-QKKYGPIYSVRMGTKTTVI 75
Query: 260 VTGIELIREV--SNREVFEGRPDGFFYTMRSFGKKLGLVFSD-GPTWHRTRRFVLKYLKN 430
V +L +EV + F GRP + S +K G+ F+D G W RR +
Sbjct: 76 VGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRK-GIAFADSGAHWQLHRRLAMATFAL 134
Query: 431 FGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQR 610
F + + I +E L + G+ I ++ + + N++ + Y D
Sbjct: 135 FKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPE 194
Query: 611 L 613
L
Sbjct: 195 L 195
>M14564-1|AAA52151.1| 508|Homo sapiens CYP17 protein.
Length = 508
Score = 50.4 bits (115), Expect = 8e-06
Identities = 45/181 (24%), Positives = 77/181 (42%), Gaps = 3/181 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
RR G YP LP+VG+L + R H+ ++ +KYG + +R+G+ V+
Sbjct: 20 RRCPGAKYPKSLLSLPLVGSLPFL---PRHGHMHNNFFKL-QKKYGPIYSVRMGTKTTVI 75
Query: 260 VTGIELIREV--SNREVFEGRPDGFFYTMRSFGKKLGLVFSD-GPTWHRTRRFVLKYLKN 430
V +L +EV + F GRP + S +K G+ F+D G W RR +
Sbjct: 76 VGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRK-GIAFADSGAHWQLHRRLAMATFAL 134
Query: 431 FGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQR 610
F + + I +E L + G+ I ++ + + N++ + Y D
Sbjct: 135 FKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPE 194
Query: 611 L 613
L
Sbjct: 195 L 195
>DQ530598-1|ABF50972.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 50.4 bits (115), Expect = 8e-06
Identities = 45/181 (24%), Positives = 77/181 (42%), Gaps = 3/181 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
RR G YP LP+VG+L + R H+ ++ +KYG + +R+G+ V+
Sbjct: 20 RRCPGAKYPKSLLSLPLVGSLPFL---PRHGHMHNNFFKL-QKKYGPIYSVRMGTKTTVI 75
Query: 260 VTGIELIREV--SNREVFEGRPDGFFYTMRSFGKKLGLVFSD-GPTWHRTRRFVLKYLKN 430
V +L +EV + F GRP + S +K G+ F+D G W RR +
Sbjct: 76 VGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRK-GIAFADSGAHWQLHRRLAMATFAL 134
Query: 431 FGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQR 610
F + + I +E L + G+ I ++ + + N++ + Y D
Sbjct: 135 FKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPE 194
Query: 611 L 613
L
Sbjct: 195 L 195
>BT020000-1|AAV38803.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 50.4 bits (115), Expect = 8e-06
Identities = 45/181 (24%), Positives = 77/181 (42%), Gaps = 3/181 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
RR G YP LP+VG+L + R H+ ++ +KYG + +R+G+ V+
Sbjct: 20 RRCPGAKYPKSLLSLPLVGSLPFL---PRHGHMHNNFFKL-QKKYGPIYSVRMGTKTTVI 75
Query: 260 VTGIELIREV--SNREVFEGRPDGFFYTMRSFGKKLGLVFSD-GPTWHRTRRFVLKYLKN 430
V +L +EV + F GRP + S +K G+ F+D G W RR +
Sbjct: 76 VGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRK-GIAFADSGAHWQLHRRLAMATFAL 134
Query: 431 FGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQR 610
F + + I +E L + G+ I ++ + + N++ + Y D
Sbjct: 135 FKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPE 194
Query: 611 L 613
L
Sbjct: 195 L 195
>BC063388-1|AAH63388.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 50.4 bits (115), Expect = 8e-06
Identities = 45/181 (24%), Positives = 77/181 (42%), Gaps = 3/181 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
RR G YP LP+VG+L + R H+ ++ +KYG + +R+G+ V+
Sbjct: 20 RRCPGAKYPKSLLSLPLVGSLPFL---PRHGHMHNNFFKL-QKKYGPIYSVRMGTKTTVI 75
Query: 260 VTGIELIREV--SNREVFEGRPDGFFYTMRSFGKKLGLVFSD-GPTWHRTRRFVLKYLKN 430
V +L +EV + F GRP + S +K G+ F+D G W RR +
Sbjct: 76 VGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRK-GIAFADSGAHWQLHRRLAMATFAL 134
Query: 431 FGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQR 610
F + + I +E L + G+ I ++ + + N++ + Y D
Sbjct: 135 FKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPE 194
Query: 611 L 613
L
Sbjct: 195 L 195
>BC062997-1|AAH62997.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 50.4 bits (115), Expect = 8e-06
Identities = 45/181 (24%), Positives = 77/181 (42%), Gaps = 3/181 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
RR G YP LP+VG+L + R H+ ++ +KYG + +R+G+ V+
Sbjct: 20 RRCPGAKYPKSLLSLPLVGSLPFL---PRHGHMHNNFFKL-QKKYGPIYSVRMGTKTTVI 75
Query: 260 VTGIELIREV--SNREVFEGRPDGFFYTMRSFGKKLGLVFSD-GPTWHRTRRFVLKYLKN 430
V +L +EV + F GRP + S +K G+ F+D G W RR +
Sbjct: 76 VGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRK-GIAFADSGAHWQLHRRLAMATFAL 134
Query: 431 FGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQR 610
F + + I +E L + G+ I ++ + + N++ + Y D
Sbjct: 135 FKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPE 194
Query: 611 L 613
L
Sbjct: 195 L 195
>AL358790-3|CAI52498.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 50.4 bits (115), Expect = 8e-06
Identities = 45/181 (24%), Positives = 77/181 (42%), Gaps = 3/181 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
RR G YP LP+VG+L + R H+ ++ +KYG + +R+G+ V+
Sbjct: 20 RRCPGAKYPKSLLSLPLVGSLPFL---PRHGHMHNNFFKL-QKKYGPIYSVRMGTKTTVI 75
Query: 260 VTGIELIREV--SNREVFEGRPDGFFYTMRSFGKKLGLVFSD-GPTWHRTRRFVLKYLKN 430
V +L +EV + F GRP + S +K G+ F+D G W RR +
Sbjct: 76 VGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRK-GIAFADSGAHWQLHRRLAMATFAL 134
Query: 431 FGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQR 610
F + + I +E L + G+ I ++ + + N++ + Y D
Sbjct: 135 FKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPE 194
Query: 611 L 613
L
Sbjct: 195 L 195
>M31153-1|AAA52140.1| 508|Homo sapiens CYP17 protein.
Length = 508
Score = 50.0 bits (114), Expect = 1e-05
Identities = 45/181 (24%), Positives = 77/181 (42%), Gaps = 3/181 (1%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
RR G YP LP+VG+L + R H+ ++ +KYG + +R+G+ V+
Sbjct: 20 RRCPGAKYPKSLLSLPLVGSLPFL---PRHGHMHNNFFKL-QKKYGPIYSVRMGTKTTVI 75
Query: 260 VTGIELIREV--SNREVFEGRPDGFFYTMRSFGKKLGLVFSD-GPTWHRTRRFVLKYLKN 430
V +L +EV + F GRP + S +K G+ F+D G W RR +
Sbjct: 76 VGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRK-GIAFADSGAHWQLHRRLAMATFAL 134
Query: 431 FGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQR 610
F + + I +E L + G+ I ++ + + N++ + Y D
Sbjct: 135 FKDGDQKLEKIICQEISTLSDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPE 194
Query: 611 L 613
L
Sbjct: 195 L 195
>M61858-1|AAA52145.1| 370|Homo sapiens CYP2C17 protein.
Length = 370
Score = 48.0 bits (109), Expect = 4e-05
Identities = 41/144 (28%), Positives = 63/144 (43%), Gaps = 2/144 (1%)
Frame = +2
Query: 401 RRFVLKYLKNFGYNSRFMNVYIGEECEALVQ-LRLADAGEPILVNQMFHITIVNILWRLV 577
RRF L L+NFG R + + EE LV+ LR +A P + N++ ++
Sbjct: 4 RRFCLITLRNFGMGKRSIEDRVQEEARCLVEELRKTNAS-PCDPTFILGCAPCNVICSII 62
Query: 578 AGKRYDLXDQRLKKLCSLVMRLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNAL 754
KR+D DQ+ L + ++V I N + + P +L L
Sbjct: 63 FHKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFSTIIDYFPG--SHNKLLKNLLTL 120
Query: 755 HQYLREIIKEHQXNLQLGAPKDVI 826
Y+ E IKEHQ +L + P+D I
Sbjct: 121 KSYVLERIKEHQESLDMNNPRDFI 144
>BC109084-1|AAI09085.1| 448|Homo sapiens CYP24A1 protein protein.
Length = 448
Score = 46.8 bits (106), Expect = 1e-04
Identities = 34/115 (29%), Positives = 53/115 (46%), Gaps = 5/115 (4%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPT P++G+LL +LW+ K H + + + +KYG + ++LGS V + L+
Sbjct: 59 PGPTSWPLLGSLLQILWKGGLKKQHDTLVE-YHKKYGKIFRMKLGSFESVHLGSPCLLEA 117
Query: 287 VSNREV-----FEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFG 436
+ E E +P + R G GL+ +G W R R K L G
Sbjct: 118 LYRTESAYPQRLEIKPWKAYRDYRKEG--YGLLILEGEDWQRVRSAFQKKLMKPG 170
>BC109083-1|AAI09084.1| 448|Homo sapiens CYP24A1 protein protein.
Length = 448
Score = 46.8 bits (106), Expect = 1e-04
Identities = 34/115 (29%), Positives = 53/115 (46%), Gaps = 5/115 (4%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPT P++G+LL +LW+ K H + + + +KYG + ++LGS V + L+
Sbjct: 59 PGPTSWPLLGSLLQILWKGGLKKQHDTLVE-YHKKYGKIFRMKLGSFESVHLGSPCLLEA 117
Query: 287 VSNREV-----FEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFG 436
+ E E +P + R G GL+ +G W R R K L G
Sbjct: 118 LYRTESAYPQRLEIKPWKAYRDYRKEG--YGLLILEGEDWQRVRSAFQKKLMKPG 170
>AL138805-3|CAM27343.1| 448|Homo sapiens cytochrome P450, family
24, subfamily A, polypeptide 1 protein.
Length = 448
Score = 46.8 bits (106), Expect = 1e-04
Identities = 34/115 (29%), Positives = 53/115 (46%), Gaps = 5/115 (4%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPT P++G+LL +LW+ K H + + + +KYG + ++LGS V + L+
Sbjct: 59 PGPTSWPLLGSLLQILWKGGLKKQHDTLVE-YHKKYGKIFRMKLGSFESVHLGSPCLLEA 117
Query: 287 VSNREV-----FEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFG 436
+ E E +P + R G GL+ +G W R R K L G
Sbjct: 118 LYRTESAYPQRLEIKPWKAYRDYRKEG--YGLLILEGEDWQRVRSAFQKKLMKPG 170
>AL138805-2|CAB91829.1| 514|Homo sapiens cytochrome P450, family
24, subfamily A, polypeptide 1 protein.
Length = 514
Score = 46.8 bits (106), Expect = 1e-04
Identities = 34/115 (29%), Positives = 53/115 (46%), Gaps = 5/115 (4%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPT P++G+LL +LW+ K H + + + +KYG + ++LGS V + L+
Sbjct: 59 PGPTSWPLLGSLLQILWKGGLKKQHDTLVE-YHKKYGKIFRMKLGSFESVHLGSPCLLEA 117
Query: 287 VSNREV-----FEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTRRFVLKYLKNFG 436
+ E E +P + R G GL+ +G W R R K L G
Sbjct: 118 LYRTESAYPQRLEIKPWKAYRDYRKEG--YGLLILEGEDWQRVRSAFQKKLMKPG 170
>L13286-1|AAA62379.1| 513|Homo sapiens 1,25-dihydroxyvitamin D3
24-hydroxylase protein.
Length = 513
Score = 46.4 bits (105), Expect = 1e-04
Identities = 32/112 (28%), Positives = 53/112 (47%), Gaps = 2/112 (1%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPT P++ +LL +LW+ K H + + + +KYG + ++LGS V + L+
Sbjct: 59 PGPTSWPLLASLLQILWKGGLKKQHDTLVE-YHKKYGKIFRMKLGSFESVHLGSPCLLEA 117
Query: 287 VSNREVFEGRPD-GFFYTMRSFGKK-LGLVFSDGPTWHRTRRFVLKYLKNFG 436
+ E R + + R + K+ GL+ +G W R R K L G
Sbjct: 118 LYRTESVPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPG 169
>CR456430-1|CAG30316.1| 446|Homo sapiens CYP2D6 protein.
Length = 446
Score = 45.6 bits (103), Expect = 2e-04
Identities = 32/96 (33%), Positives = 51/96 (53%), Gaps = 3/96 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R YPPGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYPPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKK 358
V+ G+ +RE V++ E RP + FG +
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPITQILGFGPR 115
Score = 36.7 bits (81), Expect = 0.10
Identities = 27/96 (28%), Positives = 44/96 (45%), Gaps = 3/96 (3%)
Frame = +2
Query: 512 GEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVMRLFKLVDMSG---GILNF 682
G P N + + N++ L G+R++ D R +L L K + SG +LN
Sbjct: 118 GRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLK--EESGFLREVLNA 175
Query: 683 LPFLRHFVPRLIGFTELQXIHNALHQYLREIIKEHQ 790
+P L H +P L G ++ A L E++ EH+
Sbjct: 176 VPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHR 208
>BC106757-1|AAI06758.1| 446|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 446
Score = 45.6 bits (103), Expect = 2e-04
Identities = 32/96 (33%), Positives = 51/96 (53%), Gaps = 3/96 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R YPPGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYPPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKK 358
V+ G+ +RE V++ E RP + FG +
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPITQILGFGPR 115
Score = 36.7 bits (81), Expect = 0.10
Identities = 27/96 (28%), Positives = 44/96 (45%), Gaps = 3/96 (3%)
Frame = +2
Query: 512 GEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVMRLFKLVDMSG---GILNF 682
G P N + + N++ L G+R++ D R +L L K + SG +LN
Sbjct: 118 GRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLK--EESGFLREVLNA 175
Query: 683 LPFLRHFVPRLIGFTELQXIHNALHQYLREIIKEHQ 790
+P L H +P L G ++ A L E++ EH+
Sbjct: 176 VPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHR 208
>BC066877-1|AAH66877.1| 446|Homo sapiens CYP2D6 protein protein.
Length = 446
Score = 45.6 bits (103), Expect = 2e-04
Identities = 32/96 (33%), Positives = 51/96 (53%), Gaps = 3/96 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R YPPGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYPPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKK 358
V+ G+ +RE V++ E RP + FG +
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPITQILGFGPR 115
Score = 36.7 bits (81), Expect = 0.10
Identities = 27/96 (28%), Positives = 44/96 (45%), Gaps = 3/96 (3%)
Frame = +2
Query: 512 GEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVMRLFKLVDMSG---GILNF 682
G P N + + N++ L G+R++ D R +L L K + SG +LN
Sbjct: 118 GRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLK--EESGFLREVLNA 175
Query: 683 LPFLRHFVPRLIGFTELQXIHNALHQYLREIIKEHQ 790
+P L H +P L G ++ A L E++ EH+
Sbjct: 176 VPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHR 208
>AY513607-1|AAR90938.1| 100|Homo sapiens truncated cytochrome P450
2A13 variant 4 protein.
Length = 100
Score = 45.2 bits (102), Expect = 3e-04
Identities = 29/80 (36%), Positives = 41/80 (51%), Gaps = 2/80 (2%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
R+ RG PPGPTPLP +GN L + E + S++YG + + LG VVV
Sbjct: 27 RKSRGKL-PPGPTPLPFIGNYLQLNTEQMYNSLMKI-----SERYGPVFTIHLGPRRVVV 80
Query: 260 VTGIELIRE--VSNREVFEG 313
+ G + ++E V E F G
Sbjct: 81 LCGHDAVKEALVDQAEEFSG 100
>J04813-1|AAA02993.1| 502|Homo sapiens cytochrome P450 PCN3
protein.
Length = 502
Score = 44.8 bits (101), Expect = 4e-04
Identities = 42/153 (27%), Positives = 69/153 (45%), Gaps = 8/153 (5%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKF--KCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELI 280
PGPTPLP++GN+LS KF +C+ +KYG + G G + V+ +T ++I
Sbjct: 39 PGPTPLPLLGNVLSYRQGLWKFDTECY--------KKYGKMWGTYEGQLPVLAITDPDVI 90
Query: 281 REVSNREVFEGRPDGFFYTMRSFG----KKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSR 448
R V +E + F RS G K + ++ W R R + +
Sbjct: 91 RTVLVKECY-----SVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEM 145
Query: 449 FMNVYIGEECEALVQ--LRLADAGEPILVNQMF 541
F I + + LV+ R A+ G+P+ + +F
Sbjct: 146 F--PIIAQYGDVLVRNLRREAEKGKPVTLKDIF 176
>DQ680079-1|ABG25922.1| 347|Homo sapiens truncated cytochrome P450,
family 3, subfamily A, polypeptide 5 protein.
Length = 347
Score = 44.8 bits (101), Expect = 4e-04
Identities = 42/153 (27%), Positives = 69/153 (45%), Gaps = 8/153 (5%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKF--KCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELI 280
PGPTPLP++GN+LS KF +C+ +KYG + G G + V+ +T ++I
Sbjct: 39 PGPTPLPLLGNVLSYRQGLWKFDTECY--------KKYGKMWGTYEGQLPVLAITDPDVI 90
Query: 281 REVSNREVFEGRPDGFFYTMRSFG----KKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSR 448
R V +E + F RS G K + ++ W R R + +
Sbjct: 91 RTVLVKECY-----SVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEM 145
Query: 449 FMNVYIGEECEALVQ--LRLADAGEPILVNQMF 541
F I + + LV+ R A+ G+P+ + +F
Sbjct: 146 F--PIIAQYGDVLVRNLRREAEKGKPVTLKDIF 176
>BC033862-1|AAH33862.1| 502|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 5 protein.
Length = 502
Score = 44.8 bits (101), Expect = 4e-04
Identities = 42/153 (27%), Positives = 69/153 (45%), Gaps = 8/153 (5%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKF--KCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELI 280
PGPTPLP++GN+LS KF +C+ +KYG + G G + V+ +T ++I
Sbjct: 39 PGPTPLPLLGNVLSYRQGLWKFDTECY--------KKYGKMWGTYEGQLPVLAITDPDVI 90
Query: 281 REVSNREVFEGRPDGFFYTMRSFG----KKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSR 448
R V +E + F RS G K + ++ W R R + +
Sbjct: 91 RTVLVKECY-----SVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEM 145
Query: 449 FMNVYIGEECEALVQ--LRLADAGEPILVNQMF 541
F I + + LV+ R A+ G+P+ + +F
Sbjct: 146 F--PIIAQYGDVLVRNLRREAEKGKPVTLKDIF 176
>AC005020-1|AAS02016.1| 502|Homo sapiens unknown protein.
Length = 502
Score = 44.8 bits (101), Expect = 4e-04
Identities = 42/153 (27%), Positives = 69/153 (45%), Gaps = 8/153 (5%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKF--KCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELI 280
PGPTPLP++GN+LS KF +C+ +KYG + G G + V+ +T ++I
Sbjct: 39 PGPTPLPLLGNVLSYRQGLWKFDTECY--------KKYGKMWGTYEGQLPVLAITDPDVI 90
Query: 281 REVSNREVFEGRPDGFFYTMRSFG----KKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSR 448
R V +E + F RS G K + ++ W R R + +
Sbjct: 91 RTVLVKECY-----SVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEM 145
Query: 449 FMNVYIGEECEALVQ--LRLADAGEPILVNQMF 541
F I + + LV+ R A+ G+P+ + +F
Sbjct: 146 F--PIIAQYGDVLVRNLRREAEKGKPVTLKDIF 176
>AK223008-1|BAD96728.1| 502|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 5 variant protein.
Length = 502
Score = 44.4 bits (100), Expect = 5e-04
Identities = 42/153 (27%), Positives = 69/153 (45%), Gaps = 8/153 (5%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKF--KCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELI 280
PGPTPLP++GN+LS KF +C+ +KYG + G G + V+ +T ++I
Sbjct: 39 PGPTPLPLLGNVLSYRQGLWKFDTECY--------KKYGKMWGTYEGQLPVLAITDPDVI 90
Query: 281 REVSNREVFEGRPDGFFYTMRSFG----KKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSR 448
R V +E + F RS G K + ++ W R R + +
Sbjct: 91 RTVLVKECY-----SVFTNRRSLGPVGFMKSAISLAEDEEWKRIRPLLSPTFTSGKLKEM 145
Query: 449 FMNVYIGEECEALVQ--LRLADAGEPILVNQMF 541
F I + + LV+ R A+ G+P+ + +F
Sbjct: 146 F--PIIAQYGDVLVRNLRREAEKGKPVTLKDIF 176
>DQ211355-2|ABB01373.1| 117|Homo sapiens cytochrome P450 2D6
protein.
Length = 117
Score = 42.3 bits (95), Expect = 0.002
Identities = 31/96 (32%), Positives = 50/96 (52%), Gaps = 3/96 (3%)
Frame = +2
Query: 80 RRHRGLC-YPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVV 256
RR R Y PGP PLP +GNLL V +++ + C + +++G++ L+L VV
Sbjct: 25 RRQRWAARYSPGPLPLPGLGNLLHVDFQNTPY-C----FDQLRRRFGDVFSLQLAWTPVV 79
Query: 257 VVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKK 358
V+ G+ +RE V++ E RP + FG +
Sbjct: 80 VLNGLAAVREALVTHGEDTADRPPVPITQILGFGPR 115
>J04449-1|AAA35747.1| 502|Homo sapiens cytochrome P450 nifedipine
oxidase protein.
Length = 502
Score = 41.5 bits (93), Expect = 0.004
Identities = 43/169 (25%), Positives = 73/169 (43%), Gaps = 6/169 (3%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPTPLP +GN+LS K C + +KYG + G G V+ +T ++I+
Sbjct: 39 PGPTPLPFLGNILSY----HKGFC--MFDMECHKKYGKVCGFYDGQQPVLAITDPDMIKT 92
Query: 287 VSNREVFEGRPDGFFYTMRSFG----KKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFM 454
V +E + F R FG K + ++ W R R +L G +
Sbjct: 93 VLVKECY-----SVFTNRRPFGPVGFMKSAISIAEDEEWKRLRS-LLSPTFTSGKLKEMV 146
Query: 455 NVYIGEECEALVQ--LRLADAGEPILVNQMFHITIVNILWRLVAGKRYD 595
+ I + + LV+ R A+ G+P+ + +F ++++ G D
Sbjct: 147 PI-IAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNID 194
>DQ372705-1|ABD16216.1| 150|Homo sapiens mutant cytochrome p450
protein.
Length = 150
Score = 41.5 bits (93), Expect = 0.004
Identities = 26/82 (31%), Positives = 41/82 (50%), Gaps = 2/82 (2%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
RR + PPGP P++GN +V + HL + +++YG++ +RLGS +VV
Sbjct: 43 RRRQLRSAPPGPFAWPLIGNAAAV------GQAAHLSFARLARRYGDVFQIRLGSCPIVV 96
Query: 260 VTGIELIRE--VSNREVFEGRP 319
+ G I + V F RP
Sbjct: 97 LNGERAIHQALVQQGSAFADRP 118
>AF280107-4|AAG32288.1| 106|Homo sapiens cytochrome P450
polypeptide 5 protein.
Length = 106
Score = 41.5 bits (93), Expect = 0.004
Identities = 25/69 (36%), Positives = 39/69 (56%), Gaps = 2/69 (2%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKF--KCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELI 280
PGPTPLP++GN+LS KF +C+ +KYG + G G + V+ +T ++I
Sbjct: 39 PGPTPLPLLGNVLSYRQGLWKFDTECY--------KKYGKMWGTYEGQLPVLAITDPDVI 90
Query: 281 REVSNREVF 307
R V +E +
Sbjct: 91 RTVLVKECY 99
>X12387-1|CAA30944.1| 503|Homo sapiens protein ( Human mRNA for
cytochrome P-450 (cyp3 locus). ).
Length = 503
Score = 41.1 bits (92), Expect = 0.005
Identities = 43/169 (25%), Positives = 73/169 (43%), Gaps = 6/169 (3%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPTPLP +GN+LS K C + +KYG + G G V+ +T ++I+
Sbjct: 39 PGPTPLPFLGNILSY----HKGFC--MFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKT 92
Query: 287 VSNREVFEGRPDGFFYTMRSFG----KKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFM 454
V +E + F R FG K + ++ W R R +L G +
Sbjct: 93 VLVKECY-----SVFTNRRPFGPVGFMKSAISIAEDEEWKRLRS-LLSPTFTSGKLKEMV 146
Query: 455 NVYIGEECEALVQ--LRLADAGEPILVNQMFHITIVNILWRLVAGKRYD 595
+ I + + LV+ R A+ G+P+ + +F ++++ G D
Sbjct: 147 PI-IAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNID 194
>M18907-1|AAA35745.1| 503|Homo sapiens protein ( Human P450 mRNA
encoding nifedipine oxidase, complete cds. ).
Length = 503
Score = 41.1 bits (92), Expect = 0.005
Identities = 43/169 (25%), Positives = 73/169 (43%), Gaps = 6/169 (3%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPTPLP +GN+LS K C + +KYG + G G V+ +T ++I+
Sbjct: 39 PGPTPLPFLGNILSY----HKGFC--MFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKT 92
Query: 287 VSNREVFEGRPDGFFYTMRSFG----KKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFM 454
V +E + F R FG K + ++ W R R +L G +
Sbjct: 93 VLVKECY-----SVFTNRRPFGPVGFMKSAISIAEDEEWKRLRS-LLSPTFTSGKLKEMV 146
Query: 455 NVYIGEECEALVQ--LRLADAGEPILVNQMFHITIVNILWRLVAGKRYD 595
+ I + + LV+ R A+ G+P+ + +F ++++ G D
Sbjct: 147 PI-IAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNID 194
>M14096-1|AAA35744.1| 503|Homo sapiens protein ( Human cytochrome
P-450 nifedipine oxidase mRNA, complet cds. ).
Length = 503
Score = 41.1 bits (92), Expect = 0.005
Identities = 43/169 (25%), Positives = 73/169 (43%), Gaps = 6/169 (3%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPTPLP +GN+LS K C + +KYG + G G V+ +T ++I+
Sbjct: 39 PGPTPLPFLGNILSY----HKGFC--MFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKT 92
Query: 287 VSNREVFEGRPDGFFYTMRSFG----KKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFM 454
V +E + F R FG K + ++ W R R +L G +
Sbjct: 93 VLVKECY-----SVFTNRRPFGPVGFMKSAISIAEDEEWKRLRS-LLSPTFTSGKLKEMV 146
Query: 455 NVYIGEECEALVQ--LRLADAGEPILVNQMFHITIVNILWRLVAGKRYD 595
+ I + + LV+ R A+ G+P+ + +F ++++ G D
Sbjct: 147 PI-IAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNID 194
>DQ924960-1|ABI96208.1| 503|Homo sapiens cytochrome P450 family 3
subfamily A polypeptide 4 protein.
Length = 503
Score = 41.1 bits (92), Expect = 0.005
Identities = 43/169 (25%), Positives = 73/169 (43%), Gaps = 6/169 (3%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPTPLP +GN+LS K C + +KYG + G G V+ +T ++I+
Sbjct: 39 PGPTPLPFLGNILSY----HKGFC--MFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKT 92
Query: 287 VSNREVFEGRPDGFFYTMRSFG----KKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFM 454
V +E + F R FG K + ++ W R R +L G +
Sbjct: 93 VLVKECY-----SVFTNRRPFGPVGFMKSAISIAEDEEWKRLRS-LLSPTFTSGKLKEMV 146
Query: 455 NVYIGEECEALVQ--LRLADAGEPILVNQMFHITIVNILWRLVAGKRYD 595
+ I + + LV+ R A+ G+P+ + +F ++++ G D
Sbjct: 147 PI-IAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNID 194
>DQ005611-1|AAY16980.1| 503|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 4 protein.
Length = 503
Score = 41.1 bits (92), Expect = 0.005
Identities = 43/169 (25%), Positives = 73/169 (43%), Gaps = 6/169 (3%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPTPLP +GN+LS K C + +KYG + G G V+ +T ++I+
Sbjct: 39 PGPTPLPFLGNILSY----HKGFC--MFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKT 92
Query: 287 VSNREVFEGRPDGFFYTMRSFG----KKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFM 454
V +E + F R FG K + ++ W R R +L G +
Sbjct: 93 VLVKECY-----SVFTNRRPFGPVGFMKSAISIAEDEEWKRLRS-LLSPTFTSGKLKEMV 146
Query: 455 NVYIGEECEALVQ--LRLADAGEPILVNQMFHITIVNILWRLVAGKRYD 595
+ I + + LV+ R A+ G+P+ + +F ++++ G D
Sbjct: 147 PI-IAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNID 194
>BC101631-1|AAI01632.1| 503|Homo sapiens cytochrome P450, subfamily
IIIA, polypeptide 4 protein.
Length = 503
Score = 41.1 bits (92), Expect = 0.005
Identities = 43/169 (25%), Positives = 73/169 (43%), Gaps = 6/169 (3%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPTPLP +GN+LS K C + +KYG + G G V+ +T ++I+
Sbjct: 39 PGPTPLPFLGNILSY----HKGFC--MFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKT 92
Query: 287 VSNREVFEGRPDGFFYTMRSFG----KKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFM 454
V +E + F R FG K + ++ W R R +L G +
Sbjct: 93 VLVKECY-----SVFTNRRPFGPVGFMKSAISIAEDEEWKRLRS-LLSPTFTSGKLKEMV 146
Query: 455 NVYIGEECEALVQ--LRLADAGEPILVNQMFHITIVNILWRLVAGKRYD 595
+ I + + LV+ R A+ G+P+ + +F ++++ G D
Sbjct: 147 PI-IAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNID 194
>BC069418-1|AAH69418.1| 503|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 4 protein.
Length = 503
Score = 41.1 bits (92), Expect = 0.005
Identities = 43/169 (25%), Positives = 73/169 (43%), Gaps = 6/169 (3%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPTPLP +GN+LS K C + +KYG + G G V+ +T ++I+
Sbjct: 39 PGPTPLPFLGNILSY----HKGFC--MFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKT 92
Query: 287 VSNREVFEGRPDGFFYTMRSFG----KKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFM 454
V +E + F R FG K + ++ W R R +L G +
Sbjct: 93 VLVKECY-----SVFTNRRPFGPVGFMKSAISIAEDEEWKRLRS-LLSPTFTSGKLKEMV 146
Query: 455 NVYIGEECEALVQ--LRLADAGEPILVNQMFHITIVNILWRLVAGKRYD 595
+ I + + LV+ R A+ G+P+ + +F ++++ G D
Sbjct: 147 PI-IAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNID 194
>AJ563375-1|CAD91343.1| 503|Homo sapiens cytochrome P450 protein.
Length = 503
Score = 41.1 bits (92), Expect = 0.005
Identities = 43/169 (25%), Positives = 73/169 (43%), Gaps = 6/169 (3%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPTPLP +GN+LS K C + +KYG + G G V+ +T ++I+
Sbjct: 39 PGPTPLPFLGNILSY----HKGFC--MFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKT 92
Query: 287 VSNREVFEGRPDGFFYTMRSFG----KKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFM 454
V +E + F R FG K + ++ W R R +L G +
Sbjct: 93 VLVKECY-----SVFTNRRPFGPVGFMKSAISIAEDEEWKRLRS-LLSPTFTSGKLKEMV 146
Query: 455 NVYIGEECEALVQ--LRLADAGEPILVNQMFHITIVNILWRLVAGKRYD 595
+ I + + LV+ R A+ G+P+ + +F ++++ G D
Sbjct: 147 PI-IAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNID 194
>AF280107-2|AAG32290.1| 503|Homo sapiens cytochrome P450
polypeptide 4 protein.
Length = 503
Score = 41.1 bits (92), Expect = 0.005
Identities = 43/169 (25%), Positives = 73/169 (43%), Gaps = 6/169 (3%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPTPLP +GN+LS K C + +KYG + G G V+ +T ++I+
Sbjct: 39 PGPTPLPFLGNILSY----HKGFC--MFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKT 92
Query: 287 VSNREVFEGRPDGFFYTMRSFG----KKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFM 454
V +E + F R FG K + ++ W R R +L G +
Sbjct: 93 VLVKECY-----SVFTNRRPFGPVGFMKSAISIAEDEEWKRLRS-LLSPTFTSGKLKEMV 146
Query: 455 NVYIGEECEALVQ--LRLADAGEPILVNQMFHITIVNILWRLVAGKRYD 595
+ I + + LV+ R A+ G+P+ + +F ++++ G D
Sbjct: 147 PI-IAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNID 194
>AF209389-1|AAF21034.1| 503|Homo sapiens cytochrome P450 IIIA4
protein.
Length = 503
Score = 41.1 bits (92), Expect = 0.005
Identities = 43/169 (25%), Positives = 73/169 (43%), Gaps = 6/169 (3%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPTPLP +GN+LS K C + +KYG + G G V+ +T ++I+
Sbjct: 39 PGPTPLPFLGNILSY----HKGFC--MFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKT 92
Query: 287 VSNREVFEGRPDGFFYTMRSFG----KKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFM 454
V +E + F R FG K + ++ W R R +L G +
Sbjct: 93 VLVKECY-----SVFTNRRPFGPVGFMKSAISIAEDEEWKRLRS-LLSPTFTSGKLKEMV 146
Query: 455 NVYIGEECEALVQ--LRLADAGEPILVNQMFHITIVNILWRLVAGKRYD 595
+ I + + LV+ R A+ G+P+ + +F ++++ G D
Sbjct: 147 PI-IAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNID 194
>AF182273-1|AAF13598.1| 503|Homo sapiens cytochrome P450-3A4
protein.
Length = 503
Score = 41.1 bits (92), Expect = 0.005
Identities = 43/169 (25%), Positives = 73/169 (43%), Gaps = 6/169 (3%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPTPLP +GN+LS K C + +KYG + G G V+ +T ++I+
Sbjct: 39 PGPTPLPFLGNILSY----HKGFC--MFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKT 92
Query: 287 VSNREVFEGRPDGFFYTMRSFG----KKLGLVFSDGPTWHRTRRFVLKYLKNFGYNSRFM 454
V +E + F R FG K + ++ W R R +L G +
Sbjct: 93 VLVKECY-----SVFTNRRPFGPVGFMKSAISIAEDEEWKRLRS-LLSPTFTSGKLKEMV 146
Query: 455 NVYIGEECEALVQ--LRLADAGEPILVNQMFHITIVNILWRLVAGKRYD 595
+ I + + LV+ R A+ G+P+ + +F ++++ G D
Sbjct: 147 PI-IAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNID 194
>AF171066-1|AAG43404.1| 112|Homo sapiens CYP1B1 variant protein.
Length = 112
Score = 39.1 bits (87), Expect = 0.019
Identities = 23/69 (33%), Positives = 37/69 (53%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVV 259
RR G PPGP P++GN +V + HL + +++YG++ +RLGS +VV
Sbjct: 44 RRQLGSA-PPGPFAWPLIGNAAAV------GQAAHLSFARLARRYGDVFQIRLGSCPIVV 96
Query: 260 VTGIELIRE 286
+ G I +
Sbjct: 97 LNGERAIHQ 105
>X65962-1|CAA46778.1| 356|Homo sapiens cytochrome P-450 II C
protein.
Length = 356
Score = 38.7 bits (86), Expect = 0.025
Identities = 33/134 (24%), Positives = 53/134 (39%), Gaps = 3/134 (2%)
Frame = +2
Query: 434 GYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRL 613
G R + + EE LV+ P + N++ +V KR+D DQ
Sbjct: 1 GMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNF 60
Query: 614 KKLCSLVMRLFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQXIHNAL--HQYLREIIKE 784
L F++++ + N P L P T + + N Y+RE +KE
Sbjct: 61 LTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPG----THNKVLKNVALTRSYIREKVKE 116
Query: 785 HQXNLQLGAPKDVI 826
HQ +L + P+D I
Sbjct: 117 HQASLDVNNPRDFI 130
>BC022539-1|AAH22539.1| 500|Homo sapiens cytochrome P450, family
46, subfamily A, polypeptide 1 protein.
Length = 500
Score = 38.3 bits (85), Expect = 0.034
Identities = 47/204 (23%), Positives = 84/204 (41%), Gaps = 9/204 (4%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHL--IWQSWSQKYGNLLGLRLGSINVVVVTGIEL 277
P P P ++G+L W+ + L ++ W++KYG ++ + + V+VT E
Sbjct: 34 PGPPRPSFLLGHL-PCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPES 92
Query: 278 IREVSNREVFEGRPDGFFYTMRSFGKKL---GLVFS-DGPTWHRTRRFVLKYLKNFGYNS 445
+++ + + FG++L GLV + WH+ RR + S
Sbjct: 93 VKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVS 152
Query: 446 RFMNVYIGEECEALVQL--RLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKK 619
M + E+ E LV++ AD P+ + M T ++IL + G + K
Sbjct: 153 -LMETF-NEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKP 210
Query: 620 LCSLVMRLFKLVDMSGGIL-NFLP 688
L V + + + S L FLP
Sbjct: 211 LSQAVKLMLEGITASRNTLAKFLP 234
>AF094480-1|AAD41244.1| 500|Homo sapiens cholesterol 24-hydroxylase
protein.
Length = 500
Score = 38.3 bits (85), Expect = 0.034
Identities = 47/204 (23%), Positives = 84/204 (41%), Gaps = 9/204 (4%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSVLWESRKFKCHHL--IWQSWSQKYGNLLGLRLGSINVVVVTGIEL 277
P P P ++G+L W+ + L ++ W++KYG ++ + + V+VT E
Sbjct: 34 PGPPRPSFLLGHL-PCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPES 92
Query: 278 IREVSNREVFEGRPDGFFYTMRSFGKKL---GLVFS-DGPTWHRTRRFVLKYLKNFGYNS 445
+++ + + FG++L GLV + WH+ RR + S
Sbjct: 93 VKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVS 152
Query: 446 RFMNVYIGEECEALVQL--RLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKK 619
M + E+ E LV++ AD P+ + M T ++IL + G + K
Sbjct: 153 -LMETF-NEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKP 210
Query: 620 LCSLVMRLFKLVDMSGGIL-NFLP 688
L V + + + S L FLP
Sbjct: 211 LSQAVKLMLEGITASRNTLAKFLP 234
>BC012027-1|AAH12027.1| 168|Homo sapiens CYP2U1 protein protein.
Length = 168
Score = 37.9 bits (84), Expect = 0.044
Identities = 31/100 (31%), Positives = 44/100 (44%), Gaps = 20/100 (20%)
Frame = +2
Query: 80 RRHRGLCYPPGPTPLPIVGNLLSVL---------WESRKFKC---------HHLIWQSWS 205
RR R PPGPTP P+VGN VL W S + + ++ +
Sbjct: 52 RRRRARGIPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLA 111
Query: 206 QKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRP 319
+ YG++ +G VVV++ +RE V EVF RP
Sbjct: 112 RVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRP 151
>AY390425-1|AAQ92353.1| 503|Homo sapiens cytochrome P450 CYP3A43.1
protein.
Length = 503
Score = 37.5 bits (83), Expect = 0.059
Identities = 28/99 (28%), Positives = 45/99 (45%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPTPLP +G +L L F + ++KYG + GL G ++V+ ++I+
Sbjct: 39 PGPTPLPFLGTILFYLRGLWNFD------RECNEKYGEMWGLYEGQQPMLVIMDPDMIKT 92
Query: 287 VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTR 403
V +E + + F K L F++ W R R
Sbjct: 93 VLVKECYSVFTNQMPLGPMGF-LKSALSFAEDEEWKRIR 130
>AY390424-1|AAQ92352.1| 503|Homo sapiens cytochrome P450 CYP3A43.3
protein.
Length = 503
Score = 37.5 bits (83), Expect = 0.059
Identities = 28/99 (28%), Positives = 45/99 (45%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPTPLP +G +L L F + ++KYG + GL G ++V+ ++I+
Sbjct: 39 PGPTPLPFLGTILFYLRGLWNFD------RECNEKYGEMWGLYEGQQPMLVIMDPDMIKT 92
Query: 287 VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTR 403
V +E + + F K L F++ W R R
Sbjct: 93 VLVKECYSVFTNQMPLGPMGF-LKSALSFAEDEEWKRIR 130
>AF337813-1|AAK38841.1| 503|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 503
Score = 37.5 bits (83), Expect = 0.059
Identities = 28/99 (28%), Positives = 45/99 (45%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPTPLP +G +L L F + ++KYG + GL G ++V+ ++I+
Sbjct: 39 PGPTPLPFLGTILFYLRGLWNFD------RECNEKYGEMWGLYEGQQPMLVIMDPDMIKT 92
Query: 287 VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTR 403
V +E + + F K L F++ W R R
Sbjct: 93 VLVKECYSVFTNQMPLGPMGF-LKSALSFAEDEEWKRIR 130
>AF319634-1|AAK00325.1| 503|Homo sapiens cytochrome P450 CYP3A43
protein.
Length = 503
Score = 37.5 bits (83), Expect = 0.059
Identities = 28/99 (28%), Positives = 45/99 (45%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPTPLP +G +L L F + ++KYG + GL G ++V+ ++I+
Sbjct: 39 PGPTPLPFLGTILFYLRGLWNFD------RECNEKYGEMWGLYEGQQPMLVIMDPDMIKT 92
Query: 287 VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTR 403
V +E + + F K L F++ W R R
Sbjct: 93 VLVKECYSVFTNQMPLGPMGF-LKSALSFAEDEEWKRIR 130
>AF280111-1|AAG33012.1| 250|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 250
Score = 37.5 bits (83), Expect = 0.059
Identities = 28/99 (28%), Positives = 45/99 (45%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPTPLP +G +L L F + ++KYG + GL G ++V+ ++I+
Sbjct: 39 PGPTPLPFLGTILFYLRGLWNFD------RECNEKYGEMWGLYEGQQPMLVIMDPDMIKT 92
Query: 287 VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTR 403
V +E + + F K L F++ W R R
Sbjct: 93 VLVKECYSVFTNQMPLGPMGF-LKSALSFAEDEEWKRIR 130
>AF280110-1|AAG33011.1| 420|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 420
Score = 37.5 bits (83), Expect = 0.059
Identities = 28/99 (28%), Positives = 45/99 (45%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPTPLP +G +L L F + ++KYG + GL G ++V+ ++I+
Sbjct: 39 PGPTPLPFLGTILFYLRGLWNFD------RECNEKYGEMWGLYEGQQPMLVIMDPDMIKT 92
Query: 287 VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTR 403
V +E + + F K L F++ W R R
Sbjct: 93 VLVKECYSVFTNQMPLGPMGF-LKSALSFAEDEEWKRIR 130
>AF280109-1|AAG33010.1| 504|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 504
Score = 37.5 bits (83), Expect = 0.059
Identities = 28/99 (28%), Positives = 45/99 (45%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPTPLP +G +L L F + ++KYG + GL G ++V+ ++I+
Sbjct: 39 PGPTPLPFLGTILFYLRGLWNFD------RECNEKYGEMWGLYEGQQPMLVIMDPDMIKT 92
Query: 287 VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTR 403
V +E + + F K L F++ W R R
Sbjct: 93 VLVKECYSVFTNQMPLGPMGF-LKSALSFAEDEEWKRIR 130
>AF280108-1|AAG33009.1| 503|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 503
Score = 37.5 bits (83), Expect = 0.059
Identities = 28/99 (28%), Positives = 45/99 (45%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPTPLP +G +L L F + ++KYG + GL G ++V+ ++I+
Sbjct: 39 PGPTPLPFLGTILFYLRGLWNFD------RECNEKYGEMWGLYEGQQPMLVIMDPDMIKT 92
Query: 287 VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTR 403
V +E + + F K L F++ W R R
Sbjct: 93 VLVKECYSVFTNQMPLGPMGF-LKSALSFAEDEEWKRIR 130
>AC011904-5|AAS07394.1| 504|Homo sapiens unknown protein.
Length = 504
Score = 37.5 bits (83), Expect = 0.059
Identities = 28/99 (28%), Positives = 45/99 (45%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPTPLP +G +L L F + ++KYG + GL G ++V+ ++I+
Sbjct: 39 PGPTPLPFLGTILFYLRGLWNFD------RECNEKYGEMWGLYEGQQPMLVIMDPDMIKT 92
Query: 287 VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTR 403
V +E + + F K L F++ W R R
Sbjct: 93 VLVKECYSVFTNQMPLGPMGF-LKSALSFAEDEEWKRIR 130
>AC011904-4|AAS07395.1| 503|Homo sapiens unknown protein.
Length = 503
Score = 37.5 bits (83), Expect = 0.059
Identities = 28/99 (28%), Positives = 45/99 (45%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPTPLP +G +L L F + ++KYG + GL G ++V+ ++I+
Sbjct: 39 PGPTPLPFLGTILFYLRGLWNFD------RECNEKYGEMWGLYEGQQPMLVIMDPDMIKT 92
Query: 287 VSNREVFEGRPDGFFYTMRSFGKKLGLVFSDGPTWHRTR 403
V +E + + F K L F++ W R R
Sbjct: 93 VLVKECYSVFTNQMPLGPMGF-LKSALSFAEDEEWKRIR 130
>M13785-1|AAA35742.1| 504|Homo sapiens protein ( Human liver
glucocorticoid-inducible cytochrome P-450 (HLp) mRNA,
complete cds. ).
Length = 504
Score = 36.7 bits (81), Expect = 0.10
Identities = 23/67 (34%), Positives = 35/67 (52%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPTPLP +GN+LS K C + +KYG + G G V+ +T ++I+
Sbjct: 39 PGPTPLPFLGNILSY----HKGFC--MFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKL 92
Query: 287 VSNREVF 307
V +E +
Sbjct: 93 VLVKECY 99
>D00003-1|BAA00001.1| 504|Homo sapiens cytochrome P-450 protein.
Length = 504
Score = 36.7 bits (81), Expect = 0.10
Identities = 23/67 (34%), Positives = 35/67 (52%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPTPLP +GN+LS K C + +KYG + G G V+ +T ++I+
Sbjct: 39 PGPTPLPFLGNILSY----HKGFC--MFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKL 92
Query: 287 VSNREVF 307
V +E +
Sbjct: 93 VLVKECY 99
>X58906-1|CAA41709.1| 495|Homo sapiens steroid 21-monooxygenase
protein.
Length = 495
Score = 35.5 bits (78), Expect = 0.24
Identities = 45/211 (21%), Positives = 83/211 (39%), Gaps = 3/211 (1%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFS 376
+QK+G + L LG +VVV+ I E V F GRP+ Y + S L
Sbjct: 53 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYP-DLSLG 111
Query: 377 DGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIV 556
D + + + + G M + + + + A G P+ + + F +
Sbjct: 112 DYSLLWKAHKKLTRSALLLGIRDS-MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 170
Query: 557 NILWRLVAGKRYDLXDQRLKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVPRLIGFTEL 733
+I+ L G + D + + + K S I++ +PFLR F P G L
Sbjct: 171 SIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR-FFPN-PGLRRL 227
Query: 734 QXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
+ + +++H+ +L G +D++
Sbjct: 228 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 258
>X58904-1|CAA41707.1| 371|Homo sapiens steroid 21-monooxygenase
protein.
Length = 371
Score = 35.5 bits (78), Expect = 0.24
Identities = 45/211 (21%), Positives = 83/211 (39%), Gaps = 3/211 (1%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFS 376
+QK+G + L LG +VVV+ I E V F GRP+ Y + S L
Sbjct: 52 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYP-DLSLG 110
Query: 377 DGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIV 556
D + + + + G M + + + + A G P+ + + F +
Sbjct: 111 DYSLLWKAHKKLTRSALLLGIRDS-MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 169
Query: 557 NILWRLVAGKRYDLXDQRLKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVPRLIGFTEL 733
+I+ L G + D + + + K S I++ +PFLR F P G L
Sbjct: 170 SIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR-FFPN-PGLRRL 226
Query: 734 QXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
+ + +++H+ +L G +D++
Sbjct: 227 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 257
>X58902-1|CAA41706.1| 372|Homo sapiens steroid 21-monooxygenase
protein.
Length = 372
Score = 35.5 bits (78), Expect = 0.24
Identities = 45/211 (21%), Positives = 83/211 (39%), Gaps = 3/211 (1%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFS 376
+QK+G + L LG +VVV+ I E V F GRP+ Y + S L
Sbjct: 53 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYP-DLSLG 111
Query: 377 DGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIV 556
D + + + + G M + + + + A G P+ + + F +
Sbjct: 112 DYSLLWKAHKKLTRSALLLGIRDS-MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 170
Query: 557 NILWRLVAGKRYDLXDQRLKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVPRLIGFTEL 733
+I+ L G + D + + + K S I++ +PFLR F P G L
Sbjct: 171 SIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR-FFPN-PGLRRL 227
Query: 734 QXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
+ + +++H+ +L G +D++
Sbjct: 228 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 258
>X58900-1|CAA41704.1| 372|Homo sapiens steroid 21-monooxygenase
protein.
Length = 372
Score = 35.5 bits (78), Expect = 0.24
Identities = 45/211 (21%), Positives = 83/211 (39%), Gaps = 3/211 (1%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFS 376
+QK+G + L LG +VVV+ I E V F GRP+ Y + S L
Sbjct: 53 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYP-DLSLG 111
Query: 377 DGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIV 556
D + + + + G M + + + + A G P+ + + F +
Sbjct: 112 DYSLLWKAHKKLTRSALLLGIRDS-MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 170
Query: 557 NILWRLVAGKRYDLXDQRLKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVPRLIGFTEL 733
+I+ L G + D + + + K S I++ +PFLR F P G L
Sbjct: 171 SIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR-FFPN-PGLRRL 227
Query: 734 QXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
+ + +++H+ +L G +D++
Sbjct: 228 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 258
>X54807-1|CAA38578.1| 56|Homo sapiens unspecific monooxygenase
protein.
Length = 56
Score = 35.5 bits (78), Expect = 0.24
Identities = 12/16 (75%), Positives = 15/16 (93%)
Frame = +2
Query: 104 PPGPTPLPIVGNLLSV 151
PPGPTPLPI+GN+L +
Sbjct: 30 PPGPTPLPIIGNMLQI 45
>M28548-1|AAA52065.1| 495|Homo sapiens protein ( Human mutant
21-hydroxylase B gene, complete cds. ).
Length = 495
Score = 35.5 bits (78), Expect = 0.24
Identities = 45/211 (21%), Positives = 83/211 (39%), Gaps = 3/211 (1%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFS 376
+QK+G + L LG +VVV+ I E V F GRP+ Y + S L
Sbjct: 53 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYP-DLSLG 111
Query: 377 DGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIV 556
D + + + + G M + + + + A G P+ + + F +
Sbjct: 112 DYSLLWKAHKKLTRSALLLGIRDS-MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 170
Query: 557 NILWRLVAGKRYDLXDQRLKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVPRLIGFTEL 733
+I+ L G + D + + + K S I++ +PFLR F P G L
Sbjct: 171 SIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR-FFPN-PGLRRL 227
Query: 734 QXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
+ + +++H+ +L G +D++
Sbjct: 228 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 258
>M26856-1|AAA52064.1| 495|Homo sapiens protein ( Human
21-hydroxylase B gene, complete cds. ).
Length = 495
Score = 35.5 bits (78), Expect = 0.24
Identities = 45/211 (21%), Positives = 83/211 (39%), Gaps = 3/211 (1%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFS 376
+QK+G + L LG +VVV+ I E V F GRP+ Y + S L
Sbjct: 53 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYP-DLSLG 111
Query: 377 DGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIV 556
D + + + + G M + + + + A G P+ + + F +
Sbjct: 112 DYSLLWKAHKKLTRSALLLGIRDS-MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 170
Query: 557 NILWRLVAGKRYDLXDQRLKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVPRLIGFTEL 733
+I+ L G + D + + + K S I++ +PFLR F P G L
Sbjct: 171 SIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR-FFPN-PGLRRL 227
Query: 734 QXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
+ + +++H+ +L G +D++
Sbjct: 228 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 258
>M21550-1|AAA52063.1| 495|Homo sapiens CYP21 protein.
Length = 495
Score = 35.5 bits (78), Expect = 0.24
Identities = 45/211 (21%), Positives = 83/211 (39%), Gaps = 3/211 (1%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFS 376
+QK+G + L LG +VVV+ I E V F GRP+ Y + S L
Sbjct: 53 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYP-DLSLG 111
Query: 377 DGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIV 556
D + + + + G M + + + + A G P+ + + F +
Sbjct: 112 DYSLLWKAHKKLTRSALLLGIRDS-MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 170
Query: 557 NILWRLVAGKRYDLXDQRLKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVPRLIGFTEL 733
+I+ L G + D + + + K S I++ +PFLR F P G L
Sbjct: 171 SIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR-FFPN-PGLRRL 227
Query: 734 QXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
+ + +++H+ +L G +D++
Sbjct: 228 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 258
>M13936-1|AAA59695.1| 494|Homo sapiens CYP21P protein.
Length = 494
Score = 35.5 bits (78), Expect = 0.24
Identities = 45/211 (21%), Positives = 83/211 (39%), Gaps = 3/211 (1%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFS 376
+QK+G + L LG +VVV+ I E V F GRP+ Y + S L
Sbjct: 52 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYP-DLSLG 110
Query: 377 DGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIV 556
D + + + + G M + + + + A G P+ + + F +
Sbjct: 111 DYSLLWKAHKKLTRSALLLGIRDS-MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 169
Query: 557 NILWRLVAGKRYDLXDQRLKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVPRLIGFTEL 733
+I+ L G + D + + + K S I++ +PFLR F P G L
Sbjct: 170 SIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR-FFPN-PGLRRL 226
Query: 734 QXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
+ + +++H+ +L G +D++
Sbjct: 227 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 257
>M12792-1|AAB59440.1| 494|Homo sapiens steroid 21-hydroxylase
protein.
Length = 494
Score = 35.5 bits (78), Expect = 0.24
Identities = 45/211 (21%), Positives = 83/211 (39%), Gaps = 3/211 (1%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFS 376
+QK+G + L LG +VVV+ I E V F GRP+ Y + S L
Sbjct: 52 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYP-DLSLG 110
Query: 377 DGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIV 556
D + + + + G M + + + + A G P+ + + F +
Sbjct: 111 DYSLLWKAHKKLTRSALLLGIRDS-MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 169
Query: 557 NILWRLVAGKRYDLXDQRLKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVPRLIGFTEL 733
+I+ L G + D + + + K S I++ +PFLR F P G L
Sbjct: 170 SIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR-FFPN-PGLRRL 226
Query: 734 QXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
+ + +++H+ +L G +D++
Sbjct: 227 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 257
>BX679671-8|CAM26070.1| 494|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 494
Score = 35.5 bits (78), Expect = 0.24
Identities = 45/211 (21%), Positives = 83/211 (39%), Gaps = 3/211 (1%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFS 376
+QK+G + L LG +VVV+ I E V F GRP+ Y + S L
Sbjct: 52 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYP-DLSLG 110
Query: 377 DGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIV 556
D + + + + G M + + + + A G P+ + + F +
Sbjct: 111 DYSLLWKAHKKLTRSALLLGIRDS-MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 169
Query: 557 NILWRLVAGKRYDLXDQRLKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVPRLIGFTEL 733
+I+ L G + D + + + K S I++ +PFLR F P G L
Sbjct: 170 SIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR-FFPN-PGLRRL 226
Query: 734 QXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
+ + +++H+ +L G +D++
Sbjct: 227 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 257
>BC125182-1|AAI25183.1| 494|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 494
Score = 35.5 bits (78), Expect = 0.24
Identities = 45/211 (21%), Positives = 83/211 (39%), Gaps = 3/211 (1%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFS 376
+QK+G + L LG +VVV+ I E V F GRP+ Y + S L
Sbjct: 52 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYP-DLSLG 110
Query: 377 DGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIV 556
D + + + + G M + + + + A G P+ + + F +
Sbjct: 111 DYSLLWKAHKKLTRSALLLGIRDS-MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 169
Query: 557 NILWRLVAGKRYDLXDQRLKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVPRLIGFTEL 733
+I+ L G + D + + + K S I++ +PFLR F P G L
Sbjct: 170 SIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR-FFPN-PGLRRL 226
Query: 734 QXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
+ + +++H+ +L G +D++
Sbjct: 227 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 257
>BC125181-1|AAI25182.1| 495|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 495
Score = 35.5 bits (78), Expect = 0.24
Identities = 45/211 (21%), Positives = 83/211 (39%), Gaps = 3/211 (1%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFS 376
+QK+G + L LG +VVV+ I E V F GRP+ Y + S L
Sbjct: 53 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYP-DLSLG 111
Query: 377 DGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIV 556
D + + + + G M + + + + A G P+ + + F +
Sbjct: 112 DYSLLWKAHKKLTRSALLLGIRDS-MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 170
Query: 557 NILWRLVAGKRYDLXDQRLKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVPRLIGFTEL 733
+I+ L G + D + + + K S I++ +PFLR F P G L
Sbjct: 171 SIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR-FFPN-PGLRRL 227
Query: 734 QXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
+ + +++H+ +L G +D++
Sbjct: 228 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 258
>AM183951-1|CAJ75805.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 35.5 bits (78), Expect = 0.24
Identities = 45/211 (21%), Positives = 83/211 (39%), Gaps = 3/211 (1%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFS 376
+QK+G + L LG +VVV+ I E V F GRP+ Y + S L
Sbjct: 52 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYP-DLSLG 110
Query: 377 DGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIV 556
D + + + + G M + + + + A G P+ + + F +
Sbjct: 111 DYSLLWKAHKKLTRSALLLGIRDS-MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 169
Query: 557 NILWRLVAGKRYDLXDQRLKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVPRLIGFTEL 733
+I+ L G + D + + + K S I++ +PFLR F P G L
Sbjct: 170 SIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR-FFPN-PGLRRL 226
Query: 734 QXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
+ + +++H+ +L G +D++
Sbjct: 227 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 257
>AM183950-1|CAJ75804.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 35.5 bits (78), Expect = 0.24
Identities = 45/211 (21%), Positives = 83/211 (39%), Gaps = 3/211 (1%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFS 376
+QK+G + L LG +VVV+ I E V F GRP+ Y + S L
Sbjct: 52 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYP-DLSLG 110
Query: 377 DGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIV 556
D + + + + G M + + + + A G P+ + + F +
Sbjct: 111 DYSLLWKAHKKLTRSALLLGIRDS-MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 169
Query: 557 NILWRLVAGKRYDLXDQRLKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVPRLIGFTEL 733
+I+ L G + D + + + K S I++ +PFLR F P G L
Sbjct: 170 SIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR-FFPN-PGLRRL 226
Query: 734 QXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
+ + +++H+ +L G +D++
Sbjct: 227 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 257
>AM183949-1|CAJ75803.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 35.5 bits (78), Expect = 0.24
Identities = 45/211 (21%), Positives = 83/211 (39%), Gaps = 3/211 (1%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFS 376
+QK+G + L LG +VVV+ I E V F GRP+ Y + S L
Sbjct: 52 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYP-DLSLG 110
Query: 377 DGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIV 556
D + + + + G M + + + + A G P+ + + F +
Sbjct: 111 DYSLLWKAHKKLTRSALLLGIRDS-MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 169
Query: 557 NILWRLVAGKRYDLXDQRLKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVPRLIGFTEL 733
+I+ L G + D + + + K S I++ +PFLR F P G L
Sbjct: 170 SIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR-FFPN-PGLRRL 226
Query: 734 QXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
+ + +++H+ +L G +D++
Sbjct: 227 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 257
>AM183948-1|CAJ75802.1| 494|Homo sapiens steroid 21-hydroxylase
protein.
Length = 494
Score = 35.5 bits (78), Expect = 0.24
Identities = 45/211 (21%), Positives = 83/211 (39%), Gaps = 3/211 (1%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFS 376
+QK+G + L LG +VVV+ I E V F GRP+ Y + S L
Sbjct: 52 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYP-DLSLG 110
Query: 377 DGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIV 556
D + + + + G M + + + + A G P+ + + F +
Sbjct: 111 DYSLLWKAHKKLTRSALLLGIRDS-MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 169
Query: 557 NILWRLVAGKRYDLXDQRLKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVPRLIGFTEL 733
+I+ L G + D + + + K S I++ +PFLR F P G L
Sbjct: 170 SIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR-FFPN-PGLRRL 226
Query: 734 QXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
+ + +++H+ +L G +D++
Sbjct: 227 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 257
>AM086565-1|CAJ31104.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 35.5 bits (78), Expect = 0.24
Identities = 45/211 (21%), Positives = 83/211 (39%), Gaps = 3/211 (1%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFS 376
+QK+G + L LG +VVV+ I E V F GRP+ Y + S L
Sbjct: 52 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYP-DLSLG 110
Query: 377 DGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIV 556
D + + + + G M + + + + A G P+ + + F +
Sbjct: 111 DYSLLWKAHKKLTRSALLLGIRDS-MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 169
Query: 557 NILWRLVAGKRYDLXDQRLKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVPRLIGFTEL 733
+I+ L G + D + + + K S I++ +PFLR F P G L
Sbjct: 170 SIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR-FFPN-PGLRRL 226
Query: 734 QXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
+ + +++H+ +L G +D++
Sbjct: 227 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 257
>AL929593-1|CAI41779.1| 495|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 495
Score = 35.5 bits (78), Expect = 0.24
Identities = 45/211 (21%), Positives = 83/211 (39%), Gaps = 3/211 (1%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFS 376
+QK+G + L LG +VVV+ I E V F GRP+ Y + S L
Sbjct: 53 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYP-DLSLG 111
Query: 377 DGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIV 556
D + + + + G M + + + + A G P+ + + F +
Sbjct: 112 DYSLLWKAHKKLTRSALLLGIRDS-MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 170
Query: 557 NILWRLVAGKRYDLXDQRLKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVPRLIGFTEL 733
+I+ L G + D + + + K S I++ +PFLR F P G L
Sbjct: 171 SIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR-FFPN-PGLRRL 227
Query: 734 QXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
+ + +++H+ +L G +D++
Sbjct: 228 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 258
>AL662849-18|CAI17479.1| 495|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 495
Score = 35.5 bits (78), Expect = 0.24
Identities = 45/211 (21%), Positives = 83/211 (39%), Gaps = 3/211 (1%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFS 376
+QK+G + L LG +VVV+ I E V F GRP+ Y + S L
Sbjct: 53 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYP-DLSLG 111
Query: 377 DGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIV 556
D + + + + G M + + + + A G P+ + + F +
Sbjct: 112 DYSLLWKAHKKLTRSALLLGIRDS-MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 170
Query: 557 NILWRLVAGKRYDLXDQRLKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVPRLIGFTEL 733
+I+ L G + D + + + K S I++ +PFLR F P G L
Sbjct: 171 SIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR-FFPN-PGLRRL 227
Query: 734 QXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
+ + +++H+ +L G +D++
Sbjct: 228 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 258
>AL645922-24|CAI41754.1| 495|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 495
Score = 35.5 bits (78), Expect = 0.24
Identities = 45/211 (21%), Positives = 83/211 (39%), Gaps = 3/211 (1%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFS 376
+QK+G + L LG +VVV+ I E V F GRP+ Y + S L
Sbjct: 53 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYP-DLSLG 111
Query: 377 DGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIV 556
D + + + + G M + + + + A G P+ + + F +
Sbjct: 112 DYSLLWKAHKKLTRSALLLGIRDS-MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 170
Query: 557 NILWRLVAGKRYDLXDQRLKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVPRLIGFTEL 733
+I+ L G + D + + + K S I++ +PFLR F P G L
Sbjct: 171 SIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR-FFPN-PGLRRL 227
Query: 734 QXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
+ + +++H+ +L G +D++
Sbjct: 228 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 258
>AL049547-7|CAB89301.1| 495|Homo sapiens dJ34F7.3 (cytochrome P450,
subfamily XXIA (steroid 21-hydroxylase, congenital a
protein.
Length = 495
Score = 35.5 bits (78), Expect = 0.24
Identities = 45/211 (21%), Positives = 83/211 (39%), Gaps = 3/211 (1%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFS 376
+QK+G + L LG +VVV+ I E V F GRP+ Y + S L
Sbjct: 53 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYP-DLSLG 111
Query: 377 DGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIV 556
D + + + + G M + + + + A G P+ + + F +
Sbjct: 112 DYSLLWKAHKKLTRSALLLGIRDS-MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 170
Query: 557 NILWRLVAGKRYDLXDQRLKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVPRLIGFTEL 733
+I+ L G + D + + + K S I++ +PFLR F P G L
Sbjct: 171 SIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR-FFPN-PGLRRL 227
Query: 734 QXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
+ + +++H+ +L G +D++
Sbjct: 228 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 258
>AF280107-1|AAG32291.1| 106|Homo sapiens cytochrome P450
polypeptide 43 protein.
Length = 106
Score = 35.5 bits (78), Expect = 0.24
Identities = 21/67 (31%), Positives = 35/67 (52%)
Frame = +2
Query: 107 PGPTPLPIVGNLLSVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIRE 286
PGPTPLP +G +L L F + ++KYG + GL G ++V+ ++I+
Sbjct: 39 PGPTPLPFLGTILFYLRGLWNFD------RECNEKYGEMWGLYEGQQPMLVIMDPDMIKT 92
Query: 287 VSNREVF 307
V +E +
Sbjct: 93 VLVKECY 99
>AF019413-2|AAB67982.1| 495|Homo sapiens cytochrome P450
21-hydroxylase protein.
Length = 495
Score = 35.5 bits (78), Expect = 0.24
Identities = 45/211 (21%), Positives = 83/211 (39%), Gaps = 3/211 (1%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFS 376
+QK+G + L LG +VVV+ I E V F GRP+ Y + S L
Sbjct: 53 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYP-DLSLG 111
Query: 377 DGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIV 556
D + + + + G M + + + + A G P+ + + F +
Sbjct: 112 DYSLLWKAHKKLTRSALLLGIRDS-MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 170
Query: 557 NILWRLVAGKRYDLXDQRLKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVPRLIGFTEL 733
+I+ L G + D + + + K S I++ +PFLR F P G L
Sbjct: 171 SIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR-FFPN-PGLRRL 227
Query: 734 QXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
+ + +++H+ +L G +D++
Sbjct: 228 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 258
>AM183947-1|CAJ75801.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 35.1 bits (77), Expect = 0.31
Identities = 48/212 (22%), Positives = 85/212 (40%), Gaps = 4/212 (1%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFS 376
+QK+G + L LG +VVV+ I E V F GRP+ Y + S L
Sbjct: 52 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYP-DLSLG 110
Query: 377 DGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIV 556
D + + + + G M + + + + A G P+ + + F +
Sbjct: 111 DYSLLWKAHKKLTRSALLLGIRDS-MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 169
Query: 557 NILWRLVAGKRYDLXDQRLKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVPRLIGFTEL 733
+I+ L G + D + + + K S I++ +PFLR F P G L
Sbjct: 170 SIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR-FFPN-PGLRRL 226
Query: 734 -QXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
Q I H + +++H+ +L G +D++
Sbjct: 227 KQAIEKGDH-IVEMQLRQHKESLVAGQWRDMM 257
>AB209700-1|BAD92937.1| 336|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 1 variant protein.
Length = 336
Score = 35.1 bits (77), Expect = 0.31
Identities = 27/116 (23%), Positives = 50/116 (43%), Gaps = 3/116 (2%)
Frame = +2
Query: 485 LVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLXDQRLKKLCSLVMRLFKLVDMS 664
LV L G+P + N++ ++ K +D D++ +L L F L+
Sbjct: 50 LVALTACFVGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTP 109
Query: 665 G-GILNFLPFLRHFVPRLIGFTELQXIHNA--LHQYLREIIKEHQXNLQLGAPKDV 823
+ N P H++P + + I N + +Y+ E +KEH +L P+D+
Sbjct: 110 WLQLYNNFPSFLHYLPG----SHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDL 161
>AM183946-1|CAJ75800.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 34.7 bits (76), Expect = 0.41
Identities = 45/211 (21%), Positives = 83/211 (39%), Gaps = 3/211 (1%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFS 376
+QK+G + L LG +VVV+ I E V F GRP+ Y + S L
Sbjct: 52 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYP-DLSLG 110
Query: 377 DGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIV 556
D + + + + G M + + + + A G P+ + + F +
Sbjct: 111 DYSLLWKAHKKLTRSALLLGIRDS-MEPVVEQLTQEFRERMRAQPGTPVAIEEEFSLLTC 169
Query: 557 NILWRLVAGKRYDLXDQRLKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVPRLIGFTEL 733
+I+ L G + D + + + K S I++ +PFLR F P G L
Sbjct: 170 SIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR-FFPN-PGLRRL 226
Query: 734 QXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
+ + +++H+ +L G +D++
Sbjct: 227 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 257
>BX538127-1|CAD98029.1| 310|Homo sapiens hypothetical protein
protein.
Length = 310
Score = 34.3 bits (75), Expect = 0.55
Identities = 24/75 (32%), Positives = 35/75 (46%), Gaps = 1/75 (1%)
Frame = +2
Query: 401 RRFVLKYLKNFGYNSRFMNVYIGEECEALV-QLRLADAGEPILVNQMFHITIVNILWRLV 577
RRF L L+NFG R + + EE LV +LR +A P + N++ ++
Sbjct: 3 RRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNA-SPCDPAFILGCAPCNVICSVI 61
Query: 578 AGKRYDLXDQRLKKL 622
R+D DQR L
Sbjct: 62 FHDRFDYKDQRFLNL 76
>AL512656-1|CAI15290.1| 488|Homo sapiens annexin A7 protein.
Length = 488
Score = 34.3 bits (75), Expect = 0.55
Identities = 18/53 (33%), Positives = 26/53 (49%)
Frame = -1
Query: 384 GPSEKTNPSFFPNDLMV*KNPSGLPSNTSRFETSLMSSIPVTTTTLMDPSLKP 226
GP++ P FP M + P G P+ S+ T SS PV + +D S +P
Sbjct: 116 GPAQVPLPGGFPGGQMPSQYPGGQPTYPSQINTDSFSSYPVFSPVSLDYSSEP 168
>AL353731-3|CAI52484.1| 488|Homo sapiens annexin A7 protein.
Length = 488
Score = 34.3 bits (75), Expect = 0.55
Identities = 18/53 (33%), Positives = 26/53 (49%)
Frame = -1
Query: 384 GPSEKTNPSFFPNDLMV*KNPSGLPSNTSRFETSLMSSIPVTTTTLMDPSLKP 226
GP++ P FP M + P G P+ S+ T SS PV + +D S +P
Sbjct: 116 GPAQVPLPGGFPGGQMPSQYPGGQPTYPSQINTDSFSSYPVFSPVSLDYSSEP 168
>AM183945-1|CAJ75799.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 33.9 bits (74), Expect = 0.72
Identities = 47/211 (22%), Positives = 83/211 (39%), Gaps = 3/211 (1%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFS 376
+QK+G + L LG +VVV+ I E V F GRP+ Y + S L
Sbjct: 52 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYP-DLSLG 110
Query: 377 DGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIV 556
D + + + + G V E ++R A G P+ + + F +
Sbjct: 111 DYSLLWKAHKKLTRSALLLGIRDSMEPVEEQLTQEFCERMR-AQPGTPVAIEEEFSLLTC 169
Query: 557 NILWRLVAGKRYDLXDQRLKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVPRLIGFTEL 733
+I+ L G + D + + + K S I++ +PFLR F P G L
Sbjct: 170 SIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR-FFPN-PGLRRL 226
Query: 734 QXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
+ + +++H+ +L G +D++
Sbjct: 227 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 257
>X58898-1|CAA41702.1| 371|Homo sapiens steroid 21-monooxygenase
protein.
Length = 371
Score = 33.5 bits (73), Expect = 0.95
Identities = 45/211 (21%), Positives = 82/211 (38%), Gaps = 3/211 (1%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFS 376
+QK+G + L LG +VVV+ I E V F GRP+ Y + S L
Sbjct: 52 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYP-DLSLG 110
Query: 377 DGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIV 556
D + + + + G M + + + + A G P+ + + F +
Sbjct: 111 DYSLLWKAHKKLTRSALLLGIRDS-MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 169
Query: 557 NILWRLVAGKRYDLXDQRLKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVPRLIGFTEL 733
+I L G + D + + + K S I++ +PFLR F P G L
Sbjct: 170 SINCYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR-FFPN-PGLRRL 226
Query: 734 QXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
+ + +++H+ +L G +D++
Sbjct: 227 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 257
>AM086564-1|CAJ31103.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 33.5 bits (73), Expect = 0.95
Identities = 45/211 (21%), Positives = 82/211 (38%), Gaps = 3/211 (1%)
Frame = +2
Query: 203 SQKYGNLLGLRLGSINVVVVTGIELIRE--VSNREVFEGRPDGFFYTMRSFGKKLGLVFS 376
+QK+G + L LG +VVV+ I E V F GRP+ Y + S L
Sbjct: 52 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYP-DLSLG 110
Query: 377 DGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIV 556
D + + + + G M + + + + A G P+ + + F
Sbjct: 111 DYSLLWKAHKKLTRSALLLGIRDS-MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSPLTC 169
Query: 557 NILWRLVAGKRYDLXDQRLKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVPRLIGFTEL 733
+I+ L G + D + + + K S I++ +PFLR F P G L
Sbjct: 170 SIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR-FFPN-PGLRRL 226
Query: 734 QXIHNALHQYLREIIKEHQXNLQLGAPKDVI 826
+ + +++H+ +L G +D++
Sbjct: 227 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 257
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 132,435,758
Number of Sequences: 237096
Number of extensions: 3089386
Number of successful extensions: 6988
Number of sequences better than 10.0: 261
Number of HSP's better than 10.0 without gapping: 6250
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6664
length of database: 76,859,062
effective HSP length: 89
effective length of database: 55,757,518
effective search space used: 10370898348
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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