Bombyx BLAST Result against human

BLASTX 2.2.12 [Aug-07-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= fcaL-P03_F_I16
         (829 letters)

Database: human 
           237,096 sequences; 76,859,062 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

BC132767-1|AAI32768.1|  544|Homo sapiens cytochrome P450, family...   151   4e-36
AY343323-1|AAQ21380.1|  544|Homo sapiens cytochrome P450 protein.     151   4e-36
X02612-1|CAA26458.1|  512|Homo sapiens cytochrome P(1)-450 protein.   137   5e-32
X04300-1|CAA27843.1|  512|Homo sapiens P-450 c protein.               136   9e-32
EF094025-1|ABK41999.1|  512|Homo sapiens cytochrome P450, family...   136   9e-32
BC023019-1|AAH23019.1|  512|Homo sapiens cytochrome P450, family...   136   9e-32
AK223113-1|BAD96833.1|  512|Homo sapiens cytochrome P450, family...   136   9e-32
AF253322-1|AAK25727.1|  512|Homo sapiens cytochrome P450 protein.     136   9e-32
K03191-1|AAA52139.1|  512|Homo sapiens CYP1A1 protein.                136   1e-31
AK223108-1|BAD96828.1|  512|Homo sapiens cytochrome P450, family...   135   2e-31
BC067430-1|AAH67430.1|  491|Homo sapiens cytochrome P450, family...   133   9e-31
BC067431-1|AAH67431.1|  491|Homo sapiens cytochrome P450, family...   131   3e-30
M29874-1|AAA52144.1|  491|Homo sapiens CYP2B protein.                 131   3e-30
DQ298753-1|ABB84469.1|  491|Homo sapiens cytochrome P450, family...   131   3e-30
AC023172-1|AAF32444.1|  491|Homo sapiens CYP2B6 protein.              131   3e-30
AF182277-1|AAF13602.1|  491|Homo sapiens cytochrome P450-2B6 pro...   130   5e-30
Y00498-1|CAA68550.1|  490|Homo sapiens IIC2 protein.                  128   2e-29
M21941-1|AAA52160.1|  480|Homo sapiens CYP2C protein.                 128   2e-29
BC020596-1|AAH20596.1|  490|Homo sapiens cytochrome P450, family...   128   2e-29
AY514490-1|AAR89907.1|  490|Homo sapiens cytochrome P450, family...   128   2e-29
AL359672-5|CAH71307.1|  490|Homo sapiens cytochrome P450, family...   128   2e-29
M17397-1|AAA35739.1|  490|Homo sapiens protein ( Human cytochrom...   127   6e-29
M21942-1|AAA52161.1|  462|Homo sapiens CYP2C protein.                 126   1e-28
X65962-1|CAA46778.1|  356|Homo sapiens cytochrome P-450 II C pro...   125   2e-28
AY513608-1|AAR90939.1|  494|Homo sapiens cytochrome P450 2A13 va...   124   3e-28
M61858-1|AAA52145.1|  370|Homo sapiens CYP2C17 protein.               124   4e-28
M33388-1|AAA53500.1|  497|Homo sapiens cytochrome P450 IID6 prot...   124   5e-28
M24499-1|AAA36403.1|  373|Homo sapiens cytochrome P450db1 protein.    124   5e-28
DQ282154-1|ABB77902.1|  497|Homo sapiens cytochrome P450 2D6 pro...   124   5e-28
DQ282152-1|ABB77900.1|  497|Homo sapiens cytochrome P450 2D6 pro...   124   5e-28
DQ282146-1|ABB77897.1|  497|Homo sapiens cytochrome P450 2D6 pro...   124   5e-28
DQ282145-1|ABB77896.1|  497|Homo sapiens cytochrome P450 2D6 pro...   124   5e-28
DQ282144-1|ABB77895.1|  497|Homo sapiens cytochrome P450 2D6 pro...   124   5e-28
DQ211354-2|ABB01372.1|  497|Homo sapiens cytochrome P450 2D6 pro...   124   5e-28
DQ211353-2|ABB01371.1|  497|Homo sapiens cytochrome P450 2D6 pro...   124   5e-28
DQ211353-1|ABB01370.1|  497|Homo sapiens cytochrome P450 2D6 pro...   124   5e-28
BC075024-1|AAH75024.1|  497|Homo sapiens cytochrome P450, family...   124   5e-28
BC075023-1|AAH75023.1|  497|Homo sapiens cytochrome P450, family...   124   5e-28
AY545216-1|AAS55001.1|  497|Homo sapiens cytochrome P4502D6 prot...   124   5e-28
AY513606-1|AAR90937.1|  494|Homo sapiens cytochrome P450 2A13 va...   124   5e-28
AY513605-1|AAR90936.1|  494|Homo sapiens cytochrome P450 2A13 va...   124   5e-28
AY513604-1|AAR90935.1|  494|Homo sapiens cytochrome P450 2A13 va...   124   5e-28
AF209774-1|AAG35775.1|  494|Homo sapiens cytochrome P450 2A13 pr...   124   5e-28
DQ282160-1|ABB77908.1|  497|Homo sapiens cytochrome P450 2D6 pro...   123   7e-28
DQ282159-1|ABB77907.1|  497|Homo sapiens cytochrome P450 2D6 pro...   123   7e-28
DQ282158-1|ABB77906.1|  497|Homo sapiens cytochrome P450 2D6 pro...   123   7e-28
DQ282157-1|ABB77905.1|  497|Homo sapiens cytochrome P450 2D6 pro...   123   7e-28
DQ282156-1|ABB77904.1|  497|Homo sapiens cytochrome P450 2D6 pro...   123   7e-28
DQ282147-1|ABB77898.1|  497|Homo sapiens cytochrome P450 2D6 pro...   123   7e-28
BC126858-1|AAI26859.1|  497|Homo sapiens cytochrome P450, family...   123   7e-28
BC067432-1|AAH67432.1|  497|Homo sapiens cytochrome P450, family...   123   7e-28
X08006-1|CAA30807.1|  497|Homo sapiens cytochrome P450 db1 protein.   123   9e-28
M20403-1|AAA52153.1|  497|Homo sapiens CYP2D protein.                 123   9e-28
S46963-1|AAB23864.2|  477|Homo sapiens cytochrome P-450 protein.      122   1e-27
M21940-1|AAA52159.1|  383|Homo sapiens CYP2C protein.                 122   1e-27
M21939-1|AAA52158.1|  485|Homo sapiens CYP2C protein.                 122   1e-27
M15331-1|AAA52157.1|  485|Homo sapiens CYP2C protein.                 122   1e-27
D00173-1|BAA00123.1|  487|Homo sapiens cytochrome P-450 protein.      122   1e-27
DQ282153-1|ABB77901.1|  497|Homo sapiens cytochrome P450 2D6 pro...   122   1e-27
DQ282151-1|ABB77899.1|  496|Homo sapiens cytochrome P450 2D6 pro...   122   1e-27
BC125054-1|AAI25055.1|  490|Homo sapiens cytochrome P450, family...   122   1e-27
AY702706-1|AAT94065.1|  490|Homo sapiens cytochrome P450, family...   122   1e-27
AY513609-1|AAR90940.1|  494|Homo sapiens cytochrome P450 2A13 va...   122   1e-27
AY341248-1|AAP88931.1|  490|Homo sapiens cytochrome P450, family...   122   1e-27
AL359672-1|CAH71303.1|  490|Homo sapiens cytochrome P450, family...   122   1e-27
DQ282155-1|ABB77903.1|  497|Homo sapiens cytochrome P450 2D6 pro...   122   2e-27
BC106758-1|AAI06759.1|  497|Homo sapiens cytochrome P450, family...   122   2e-27
M61854-1|AAB59426.1|  490|Homo sapiens cytochrome protein.            121   4e-27
EF122241-1|ABO41976.1|  491|Homo sapiens cytochrome P450 2F1 var...   121   4e-27
L07093-1|AAA36660.1|  468|Homo sapiens cytochrome P450 protein.       120   5e-27
CR456430-1|CAG30316.1|  446|Homo sapiens CYP2D6 protein.              120   5e-27
BC106757-1|AAI06758.1|  446|Homo sapiens cytochrome P450, family...   120   5e-27
BC066877-1|AAH66877.1|  446|Homo sapiens CYP2D6 protein protein.      120   5e-27
AY796203-1|AAV41877.1|  490|Homo sapiens cytochrome P450, family...   120   5e-27
AL583836-2|CAH74068.1|  490|Homo sapiens cytochrome P450, family...   120   5e-27
AL133513-2|CAH73444.1|  490|Homo sapiens cytochrome P450, family...   120   5e-27
M61856-1|AAB59356.1|  490|Homo sapiens cytochrome protein.            120   6e-27
BC096259-1|AAH96259.1|  443|Homo sapiens CYP2C18 protein protein.     120   6e-27
BC096258-1|AAH96258.1|  490|Homo sapiens cytochrome P450, family...   120   6e-27
BC096257-1|AAH96257.1|  490|Homo sapiens cytochrome P450, family...   120   6e-27
BC069666-1|AAH69666.1|  490|Homo sapiens cytochrome P450, family...   120   6e-27
AL583836-1|CAH74067.1|  490|Homo sapiens cytochrome P450, family...   120   6e-27
AK223510-1|BAD97230.1|  490|Homo sapiens cytochrome P450, family...   120   6e-27
U22028-1|AAB40519.1|  494|Homo sapiens cytochrome P450 protein.       119   1e-26
M33317-1|AAA52138.1|  494|Homo sapiens CYP2A protein.                 119   1e-26
M33189-1|AAA35737.1|  500|Homo sapiens protein ( Human debrisoqu...   118   2e-26
Z00036-1|CAA77335.1|  515|Homo sapiens protein ( Human mRNA for ...   118   3e-26
M55053-1|AAA52146.1|  515|Homo sapiens cytochrome P3-450 protein.     118   3e-26
M31667-1|AAA52163.1|  515|Homo sapiens CYP1A2 protein.                118   3e-26
L00389-1|AAA35738.1|  516|Homo sapiens protein ( Human cytochrom...   118   3e-26
DQ282162-1|ABB77909.1|  500|Homo sapiens cytochrome P450 2D6 pro...   118   3e-26
DQ022432-1|AAY26399.1|  516|Homo sapiens cytochrome P450, family...   118   3e-26
BC117165-1|AAI17166.1|  494|Homo sapiens cytochrome P450, family...   118   3e-26
BC067428-1|AAH67428.1|  516|Homo sapiens cytochrome P450, family...   118   3e-26
BC067427-1|AAH67427.1|  516|Homo sapiens cytochrome P450, family...   118   3e-26
BC067426-1|AAH67426.1|  516|Homo sapiens cytochrome P450, family...   118   3e-26
BC067425-1|AAH67425.1|  516|Homo sapiens cytochrome P450, family...   118   3e-26
BC067424-1|AAH67424.1|  516|Homo sapiens cytochrome P450, family...   118   3e-26
AF253322-2|AAK25728.1|  516|Homo sapiens cytochrome P450 protein.     118   3e-26
L16876-1|AAA02630.1|  490|Homo sapiens cytochrome P-4502C18 prot...   118   3e-26
BC067429-1|AAH67429.1|  516|Homo sapiens cytochrome P450, family...   117   5e-26
AF182274-1|AAF13599.1|  516|Homo sapiens cytochrome P450-1A2 pro...   117   6e-26
AB209492-1|BAD92729.1|  566|Homo sapiens Debrisoquine 4-hydroxyl...   116   1e-25
BC104909-1|AAI04910.1|  501|Homo sapiens cytochrome P450, family...   116   1e-25
BC104907-1|AAI04908.1|  501|Homo sapiens cytochrome P450, family...   116   1e-25
AY323817-1|AAQ23114.1|  501|Homo sapiens cytochrome P450 2R1 pro...   116   1e-25
AB209700-1|BAD92937.1|  336|Homo sapiens cytochrome P450, family...   115   2e-25
BC067433-1|AAH67433.1|  493|Homo sapiens cytochrome P450, family...   115   2e-25
AF182276-1|AAF13601.1|  493|Homo sapiens cytochrome P450-2E1 pro...   115   2e-25
J02843-1|AAA52155.1|  493|Homo sapiens protein ( Human cytochrom...   114   3e-25
J02625-1|AAA35743.1|  493|Homo sapiens protein ( Human cytochrom...   114   3e-25
DQ515958-1|ABF47105.1|  493|Homo sapiens cytochrome P450, family...   114   3e-25
DQ149222-1|AAZ77710.1|  493|Homo sapiens cytochrome P450 2E1 pro...   114   3e-25
BC067435-1|AAH67435.1|  493|Homo sapiens cytochrome P450, family...   114   3e-25
AL161645-2|CAH70047.1|  493|Homo sapiens cytochrome P450, family...   114   3e-25
AF084225-1|AAD13753.1|  462|Homo sapiens cytochrome P450 2E1 pro...   114   3e-25
X13930-1|CAA32118.1|  494|Homo sapiens protein ( Human CYP2A4 mR...   114   4e-25
BC096255-1|AAH96255.1|  494|Homo sapiens cytochrome P450, family...   114   4e-25
AY310359-1|AAQ76692.1|  484|Homo sapiens cytochrome P450 1A1 var...   114   4e-25
AF372573-1|AAL69652.1|  495|Homo sapiens cytochrome P450 2F1 pro...   114   4e-25
X13929-1|CAA32117.1|  448|Homo sapiens P-450 IIA3 protein (1 is ...   113   7e-25
U22029-1|AAB40520.1|  494|Homo sapiens cytochrome P450 protein.       113   7e-25
M33318-1|AAA52067.1|  494|Homo sapiens CYP2A protein.                 113   7e-25
BC096256-1|AAH96256.1|  494|Homo sapiens cytochrome P450, family...   113   7e-25
BC096254-1|AAH96254.1|  494|Homo sapiens cytochrome P450, family...   113   7e-25
BC096253-1|AAH96253.3|  494|Homo sapiens cytochrome P450, family...   113   7e-25
AF182275-1|AAF13600.1|  494|Homo sapiens cytochrome P450-2A6 pro...   113   7e-25
M17398-1|AAA35740.1|  393|Homo sapiens protein ( Human cytochrom...   112   2e-24
X13897-1|CAA32097.1|  489|Homo sapiens protein ( Human mRNA for ...   111   4e-24
J02906-1|AAA52156.1|  491|Homo sapiens CYP2F1 protein.                110   5e-24
U22027-1|AAB40518.1|  494|Homo sapiens cytochrome P450 protein.       109   9e-24
AY871801-1|AAX62803.1|  483|Homo sapiens cytochrome P450 family ...   103   1e-23
U37143-1|AAC50370.2|  502|Homo sapiens cytochrome P450 monooxyge...   108   2e-23
BC032594-1|AAH32594.1|  502|Homo sapiens cytochrome P450, family...   108   2e-23
AY426985-1|AAQ93356.1|  502|Homo sapiens cytochrome P450, family...   108   2e-23
AF272142-1|AAM44456.1|  502|Homo sapiens cytochrome P450 protein.     108   2e-23
AB080265-1|BAB85489.1|  502|Homo sapiens cytochrome P450 2J2 pro...   108   3e-23
AM236047-1|CAJ84704.1|  251|Homo sapiens cytochrome P450 1A1 pro...   107   4e-23
AM233517-1|CAJ80720.1|  175|Homo sapiens cytochrome P450 1A1 pro...   107   4e-23
M12078-1|AAA52154.1|  192|Homo sapiens POR protein.                   105   2e-22
U56438-1|AAC50809.1|  543|Homo sapiens dioxin-inducible cytochro...   103   1e-21
U03688-1|AAA19567.1|  543|Homo sapiens cytochrome P450 protein.       103   1e-21
BT019979-1|AAV38782.1|  543|Homo sapiens cytochrome P450, family...   103   1e-21
BC012049-1|AAH12049.1|  543|Homo sapiens cytochrome P450, family...   103   1e-21
AY393998-1|AAQ87875.1|  543|Homo sapiens cytochrome P450, family...   103   1e-21
AF450132-1|AAM50512.1|  543|Homo sapiens cytochrome P450 CYP1B1 ...   103   1e-21
AC009229-2|AAY15039.1|  543|Homo sapiens unknown protein.             103   1e-21
M29873-1|AAA52143.1|  377|Homo sapiens CYP2B protein.                 102   2e-21
BT020001-1|AAV38804.1|  543|Homo sapiens cytochrome P450, family...   102   2e-21
BC041174-1|AAH41174.1|  377|Homo sapiens CYP2B7P1 protein protein.    102   2e-21
AY220845-1|AAO49806.1|  516|Homo sapiens cytochrome P450 protein.     101   3e-21
M63871-1|AAA59984.1|  508|Homo sapiens CYP17 protein.                 100   6e-21
M31153-1|AAA52140.1|  508|Homo sapiens CYP17 protein.                 100   6e-21
M19489-1|AAA36405.1|  508|Homo sapiens CYP17 protein.                 100   6e-21
M14564-1|AAA52151.1|  508|Homo sapiens CYP17 protein.                 100   6e-21
DQ530598-1|ABF50972.1|  508|Homo sapiens cytochrome P450, family...   100   6e-21
BT020000-1|AAV38803.1|  508|Homo sapiens cytochrome P450, family...   100   6e-21
BC063388-1|AAH63388.1|  508|Homo sapiens cytochrome P450, family...   100   6e-21
BC062997-1|AAH62997.1|  508|Homo sapiens cytochrome P450, family...   100   6e-21
AL358790-3|CAI52498.1|  508|Homo sapiens cytochrome P450, family...   100   6e-21
M12079-1|AAA52152.1|  191|Homo sapiens POR protein.                   100   7e-21
EF122244-1|ABO41979.1|  216|Homo sapiens cytochrome P450 2F1 var...    98   4e-20
BC033691-1|AAH33691.1|  504|Homo sapiens cytochrome P450, family...    95   4e-19
AY358603-1|AAQ88966.1|  504|Homo sapiens Cytochrome p450 protein.      95   4e-19
AK027605-1|BAB55227.1|  564|Homo sapiens protein ( Homo sapiens ...    95   4e-19
AF335278-1|AAK13498.1|  504|Homo sapiens cytochrome P450 2S1 pro...    95   4e-19
K03192-1|AAA52147.1|  331|Homo sapiens CYP1A1 protein.                 94   5e-19
AM233518-1|CAJ80721.1|  157|Homo sapiens cytochrome P450 1A1 pro...    93   1e-18
X51535-1|CAA35915.1|  210|Homo sapiens cytochrome P-450 HPH (120...    92   3e-18
L39102-1|AAL31348.1|  217|Homo sapiens S-mephenytoin 4-hydroxyla...    89   2e-17
AK223008-1|BAD96728.1|  502|Homo sapiens cytochrome P450, family...    87   1e-16
AF040259-1|AAD10199.1|  144|Homo sapiens cytochrome P450 1A1 pro...    86   1e-16
D00408-1|BAA00310.1|  503|Homo sapiens cytochrome P-450 HFLa pro...    86   2e-16
BC067436-1|AAH67436.1|  503|Homo sapiens cytochrome P450, family...    86   2e-16
AF315325-1|AAG48618.1|  535|Homo sapiens cytochrome P450 variant...    86   2e-16
AF280107-3|AAG32289.1|  503|Homo sapiens cytochrome P450 polypep...    86   2e-16
M28548-1|AAA52065.1|  495|Homo sapiens protein ( Human mutant 21...    85   2e-16
M26856-1|AAA52064.1|  495|Homo sapiens protein ( Human 21-hydrox...    85   2e-16
M21550-1|AAA52063.1|  495|Homo sapiens CYP21 protein.                  85   2e-16
M18907-1|AAA35745.1|  503|Homo sapiens protein ( Human P450 mRNA...    85   2e-16
M13936-1|AAA59695.1|  494|Homo sapiens CYP21P protein.                 85   2e-16
M12792-1|AAB59440.1|  494|Homo sapiens steroid 21-hydroxylase pr...    85   2e-16
J04449-1|AAA35747.1|  502|Homo sapiens cytochrome P450 nifedipin...    85   2e-16
DQ924960-1|ABI96208.1|  503|Homo sapiens cytochrome P450 family ...    85   2e-16
DQ005611-1|AAY16980.1|  503|Homo sapiens cytochrome P450, family...    85   2e-16
BX679671-8|CAM26070.1|  494|Homo sapiens cytochrome P450, family...    85   2e-16
BX679671-7|CAM26071.1|  464|Homo sapiens cytochrome P450, family...    85   2e-16
BX538127-1|CAD98029.1|  310|Homo sapiens hypothetical protein pr...    85   2e-16
BC125182-1|AAI25183.1|  494|Homo sapiens cytochrome P450, family...    85   2e-16
BC125181-1|AAI25182.1|  495|Homo sapiens cytochrome P450, family...    85   2e-16
BC101631-1|AAI01632.1|  503|Homo sapiens cytochrome P450, subfam...    85   2e-16
BC096260-1|AAH96260.1|  431|Homo sapiens CYP2C18 protein protein.      85   2e-16
BC069418-1|AAH69418.1|  503|Homo sapiens cytochrome P450, family...    85   2e-16
AM183951-1|CAJ75805.1|  494|Homo sapiens steroid 21-hydroxylase,...    85   2e-16
AM183950-1|CAJ75804.1|  494|Homo sapiens steroid 21-hydroxylase,...    85   2e-16
AM086565-1|CAJ31104.1|  494|Homo sapiens steroid 21-hydroxylase,...    85   2e-16
AL929593-2|CAI41778.1|  465|Homo sapiens cytochrome P450, family...    85   2e-16
AL929593-1|CAI41779.1|  495|Homo sapiens cytochrome P450, family...    85   2e-16
AL662849-19|CAI17480.1|  465|Homo sapiens cytochrome P450, famil...    85   2e-16
AL662849-18|CAI17479.1|  495|Homo sapiens cytochrome P450, famil...    85   2e-16
AL645922-24|CAI41754.1|  495|Homo sapiens cytochrome P450, famil...    85   2e-16
AL645922-23|CAI41755.1|  465|Homo sapiens cytochrome P450, famil...    85   2e-16
AL049547-7|CAB89301.1|  495|Homo sapiens dJ34F7.3 (cytochrome P4...    85   2e-16
AJ563376-2|CAD91645.1|  430|Homo sapiens cytochrome P450 protein.      85   2e-16
AJ563375-1|CAD91343.1|  503|Homo sapiens cytochrome P450 protein.      85   2e-16
AF280107-2|AAG32290.1|  503|Homo sapiens cytochrome P450 polypep...    85   2e-16
AF209389-1|AAF21034.1|  503|Homo sapiens cytochrome P450 IIIA4 p...    85   2e-16
AF182273-1|AAF13598.1|  503|Homo sapiens cytochrome P450-3A4 pro...    85   2e-16
AF077974-1|AAD45405.1|  403|Homo sapiens cytochrome P450 21-hydr...    85   2e-16
AF019413-2|AAB67982.1|  495|Homo sapiens cytochrome P450 21-hydr...    85   2e-16
J04813-1|AAA02993.1|  502|Homo sapiens cytochrome P450 PCN3 prot...    85   3e-16
BC033862-1|AAH33862.1|  502|Homo sapiens cytochrome P450, family...    85   3e-16
AC005020-1|AAS02016.1|  502|Homo sapiens unknown protein.              85   3e-16
X12387-1|CAA30944.1|  503|Homo sapiens protein ( Human mRNA for ...    85   4e-16
M14096-1|AAA35744.1|  503|Homo sapiens protein ( Human cytochrom...    85   4e-16
AM183949-1|CAJ75803.1|  494|Homo sapiens steroid 21-hydroxylase,...    85   4e-16
AM183947-1|CAJ75801.1|  494|Homo sapiens steroid 21-hydroxylase,...    85   4e-16
AM183946-1|CAJ75800.1|  494|Homo sapiens steroid 21-hydroxylase,...    85   4e-16
AM183945-1|CAJ75799.1|  494|Homo sapiens steroid 21-hydroxylase,...    85   4e-16
X58906-1|CAA41709.1|  495|Homo sapiens steroid 21-monooxygenase ...    83   9e-16
AM183948-1|CAJ75802.1|  494|Homo sapiens steroid 21-hydroxylase ...    83   9e-16
AM086564-1|CAJ31103.1|  494|Homo sapiens steroid 21-hydroxylase,...    83   9e-16
AJ563377-1|CAD91345.1|  353|Homo sapiens cytochrome P450 protein.      83   9e-16
AY390424-1|AAQ92352.1|  503|Homo sapiens cytochrome P450 CYP3A43...    81   4e-15
BC100981-1|AAI00982.1|  393|Homo sapiens CYP3A43 protein protein.      81   6e-15
AY390425-1|AAQ92353.1|  503|Homo sapiens cytochrome P450 CYP3A43...    81   6e-15
AF337813-1|AAK38841.1|  503|Homo sapiens cytochrome P450 subfami...    81   6e-15
AF319634-1|AAK00325.1|  503|Homo sapiens cytochrome P450 CYP3A43...    81   6e-15
AF280108-1|AAG33009.1|  503|Homo sapiens cytochrome P450 subfami...    81   6e-15
AC011904-4|AAS07395.1|  503|Homo sapiens unknown protein.              81   6e-15
AK054616-1|BAB70774.1|  465|Homo sapiens protein ( Homo sapiens ...    80   8e-15
M13785-1|AAA35742.1|  504|Homo sapiens protein ( Human liver glu...    80   1e-14
D00003-1|BAA00001.1|  504|Homo sapiens cytochrome P-450 protein.       80   1e-14
BC100982-1|AAI00983.1|  280|Homo sapiens CYP3A43 protein protein.      78   3e-14
AF280110-1|AAG33011.1|  420|Homo sapiens cytochrome P450 subfami...    78   3e-14
BC025761-1|AAH25761.2|  490|Homo sapiens cytochrome P450, family...    77   6e-14
AK000366-1|BAA91114.1|  408|Homo sapiens protein ( Homo sapiens ...    77   1e-13
L16883-1|AAD13467.1|  169|Homo sapiens cytochrome P-450 2C protein.    76   1e-13
AF280109-1|AAG33010.1|  504|Homo sapiens cytochrome P450 subfami...    76   1e-13
AC011904-5|AAS07394.1|  504|Homo sapiens unknown protein.              76   1e-13
BC022539-1|AAH22539.1|  500|Homo sapiens cytochrome P450, family...    73   2e-12
AF094480-1|AAD41244.1|  500|Homo sapiens cholesterol 24-hydroxyl...    73   2e-12
DQ016495-1|AAY34975.1|  195|Homo sapiens cytochrome P450 1B1 pro...    67   6e-11
M17252-1|AAA59985.1|  230|Homo sapiens CYP21 protein.                  66   2e-10
S67623-1|AAB29308.1|  257|Homo sapiens 25-hydroxyvitamin D 24-hy...    64   8e-10
BC060857-1|AAH60857.1|  525|Homo sapiens cytochrome P450, family...    64   8e-10
AY858838-1|AAW50795.1|  372|Homo sapiens vitamin D 24-hydroxylas...    64   8e-10
AY422002-1|AAR31180.1|  525|Homo sapiens cytochrome P450 4V2 pro...    64   8e-10
AL138805-2|CAB91829.1|  514|Homo sapiens cytochrome P450, family...    64   8e-10
AL138805-1|CAM27342.1|  372|Homo sapiens cytochrome P450, family...    64   8e-10
AK126473-1|BAC86562.1|  503|Homo sapiens protein ( Homo sapiens ...    64   8e-10
AK122600-1|BAC85487.1|  525|Homo sapiens protein ( Homo sapiens ...    64   8e-10
AF144566-1|AAD30164.1|  339|Homo sapiens cytochrome P450 epoxyge...    64   8e-10
L13286-1|AAA62379.1|  513|Homo sapiens 1,25-dihydroxyvitamin D3 ...    63   1e-09
BC028102-1|AAH28102.1|  509|Homo sapiens cytochrome P450, family...    63   1e-09
AY358537-1|AAQ88901.1|  509|Homo sapiens EFSW1929 protein.             63   1e-09
AM040940-1|CAJ13826.1|  509|Homo sapiens cytochrome P450 protein.      63   1e-09
AL450996-1|CAH71035.1|  509|Homo sapiens cytochrome P450, family...    63   1e-09
AK131355-1|BAD18508.1|  508|Homo sapiens protein ( Homo sapiens ...    63   1e-09
AK098065-1|BAC05226.1|  509|Homo sapiens protein ( Homo sapiens ...    63   1e-09
AK091806-1|BAC03751.1|  444|Homo sapiens protein ( Homo sapiens ...    63   1e-09
M80647-1|AAA60618.1|  534|Homo sapiens thromboxane synthase prot...    62   3e-09
D34625-1|BAA07011.1|  533|Homo sapiens thromboxane synthase prot...    62   3e-09
BC041157-1|AAH41157.1|  534|Homo sapiens thromboxane A synthase ...    62   3e-09
BC014117-1|AAH14117.1|  466|Homo sapiens TBXAS1 protein protein.       62   3e-09
AK223466-1|BAD97186.1|  534|Homo sapiens thromboxane A synthase ...    62   3e-09
AF233625-1|AAF99279.1|  534|Homo sapiens thromboxane synthase pr...    62   3e-09
AF233623-1|AAF99277.1|  534|Homo sapiens thromboxane synthase pr...    62   3e-09
AF233622-1|AAF99276.1|  534|Homo sapiens thromboxane synthase pr...    62   3e-09
AF233621-1|AAF99275.1|  534|Homo sapiens thromboxane synthase pr...    62   3e-09
AF233620-1|AAF99274.1|  534|Homo sapiens thromboxane synthase pr...    62   3e-09
AF233619-1|AAF99273.1|  534|Homo sapiens thromboxane synthase pr...    62   3e-09
AF233618-1|AAF99272.1|  534|Homo sapiens thromboxane synthase pr...    62   3e-09
AF233617-1|AAF99271.1|  534|Homo sapiens thromboxane synthase pr...    62   3e-09
AF233616-1|AAF99270.1|  534|Homo sapiens thromboxane synthase pr...    62   3e-09
AF233615-1|AAF99269.1|  534|Homo sapiens thromboxane synthase pr...    62   3e-09
AJ563378-3|CAD91347.1|  173|Homo sapiens hypothetical protein pr...    61   5e-09
AJ563378-2|CAD91647.1|  160|Homo sapiens cytochrome P450 protein.      61   5e-09
M80646-1|AAA60617.1|  460|Homo sapiens thromboxane synthase prot...    60   7e-09
BC093896-1|AAH93896.1|  531|Homo sapiens cytochrome P450, family...    60   1e-08
BC093894-1|AAH93894.1|  531|Homo sapiens cytochrome P450, family...    60   1e-08
BC069351-1|AAH69351.1|  531|Homo sapiens cytochrome P450, family...    60   1e-08
AK096820-1|BAC04868.1|  531|Homo sapiens protein ( Homo sapiens ...    60   1e-08
AY288916-1|AAP31972.1|  508|Homo sapiens cytochrome P450, family...    60   1e-08
AK090886-1|BAC03539.1|  337|Homo sapiens protein ( Homo sapiens ...    60   1e-08
AF256213-1|AAG00416.1|  508|Homo sapiens 25- hydroxyvitamin D-1-...    60   1e-08
AF246895-1|AAF64299.1|  508|Homo sapiens 25-hydroxyvitamin D-1-a...    60   1e-08
AF233624-1|AAF99278.1|  534|Homo sapiens thromboxane synthase pr...    60   1e-08
AF027152-1|AAC51854.1|  508|Homo sapiens P450 25-hydroxyvitamin ...    60   1e-08
AF020192-1|AAC51853.1|  508|Homo sapiens 25-hydroxyvitamin D-1-a...    60   1e-08
AB006987-1|BAA23418.1|  508|Homo sapiens 25-hydroxyvitamin D3 1-...    60   1e-08
AB005990-1|BAA22657.1|  508|Homo sapiens 25-hydroxyvitamin D3 1a...    60   1e-08
AB005989-1|BAA22656.1|  508|Homo sapiens 25-hydroxyvitamin D3 1a...    60   1e-08
AB005038-1|BAA23416.1|  508|Homo sapiens 25-hydroxyvitamin D3 1-...    60   1e-08
AY178622-1|AAO21126.1|  531|Homo sapiens steroid hydroxylase pro...    58   5e-08
X59812-1|CAA42481.1|  530|Homo sapiens Vitamin D3 25-hydroxylase...    57   9e-08
M62401-1|AAA52142.1|  531|Homo sapiens sterol 27-hydroxylase pro...    57   9e-08
BC051851-1|AAH51851.1|  531|Homo sapiens cytochrome P450, family...    57   9e-08
BC040430-1|AAH40430.1|  531|Homo sapiens cytochrome P450, family...    57   9e-08
U02388-1|AAC50052.2|  520|Homo sapiens cytochrome P450 4F2 protein.    55   3e-07
BC010358-1|AAH10358.1|  469|Homo sapiens cytochrome P450, family...    55   3e-07
D26480-1|BAA05490.1|  520|Homo sapiens leukotriene B4 omega-hydr...    54   6e-07
BC067440-1|AAH67440.1|  520|Homo sapiens cytochrome P450, family...    54   6e-07
BC067439-1|AAH67439.1|  520|Homo sapiens cytochrome P450, family...    54   6e-07
BC067437-1|AAH67437.1|  520|Homo sapiens cytochrome P450, family...    54   6e-07
AF467894-1|AAL67578.1|  520|Homo sapiens cytochrome P450, subfam...    54   6e-07
AC005336-1|AAC27730.1|  520|Homo sapiens CYP4F2 protein.               54   6e-07
AB015306-1|BAA75823.1|  520|Homo sapiens Leukotriene B4 omega-hy...    54   6e-07
EF122242-1|ABO41977.1|  321|Homo sapiens cytochrome P450 2F1 var...    54   8e-07
D12620-1|BAA02144.1|  520|Homo sapiens cytochrome P-450LTBV prot...    54   8e-07
AF237982-1|AAF63329.1|  469|Homo sapiens oxysterol 7alpha-hydrox...    54   8e-07
AB002461-1|BAA25991.1|  520|Homo sapiens leukotriene B4 omega-hy...    54   8e-07
AB002454-1|BAA25990.1|  520|Homo sapiens leukotriene B4 omega-hy...    54   8e-07
Y07508-1|CAA68807.1|  503|Homo sapiens protein ( Human mRNA for ...    53   1e-06
X13589-1|CAA31929.1|  503|Homo sapiens protein ( Human mRNA for ...    53   1e-06
M30804-1|AAA35728.1|  503|Homo sapiens protein ( Human aromatase...    53   1e-06
M28420-1|AAA52141.1|  419|Homo sapiens cytochrome P-450 aromatas...    53   1e-06
M22246-1|AAA35557.1|  503|Homo sapiens protein ( Human aromatase...    53   1e-06
M18856-1|AAA35556.1|  419|Homo sapiens protein ( Human aromatase...    53   1e-06
J04127-1|AAA52132.1|  503|Homo sapiens CYP19 protein.                  53   1e-06
DQ118405-1|AAZ23558.1|  503|Homo sapiens cytochrome P450 subfami...    53   1e-06
BC107785-1|AAI07786.1|  503|Homo sapiens cytochrome P450, family...    53   1e-06
BC035959-1|AAH35959.1|  503|Homo sapiens cytochrome P450, family...    53   1e-06
AY957953-1|AAX44046.1|  503|Homo sapiens cytochrome P450, family...    53   1e-06
AY904366-1|AAW83816.1|   62|Homo sapiens cytochrome p4502C9 prot...    53   1e-06
AY358631-1|AAQ88994.1|  505|Homo sapiens EPSW3060 protein.             53   1e-06
AY262056-1|AAO89257.1|  505|Homo sapiens cytochrome P450 protein.      53   1e-06
AL591242-1|CAH73899.1|  469|Homo sapiens cytochrome P450, family...    53   1e-06
AL450996-2|CAH71036.1|  505|Homo sapiens cytochrome P450, family...    53   1e-06
AL135960-6|CAI19734.1|  505|Homo sapiens cytochrome P450, family...    53   1e-06
AL035670-1|CAI20276.1|  469|Homo sapiens cytochrome P450, family...    53   1e-06
AY792513-1|AAV40834.1|  520|Homo sapiens cytochrome P450, family...    52   2e-06
AF054821-1|AAC08589.1|  520|Homo sapiens cytochrome P-450 protein.     52   2e-06
AJ877238-1|CAI47002.1|   97|Homo sapiens putative cytochrome P45...    52   3e-06
BC109056-1|AAI09057.1|  320|Homo sapiens CYP2F1 protein protein.       52   3e-06
BC039307-1|AAH39307.1|  372|Homo sapiens cytochrome P450, family...    52   3e-06
AK131190-1|BAD18388.1|  372|Homo sapiens .-.-).  protein.              52   3e-06
BC035350-1|AAH35350.1|  524|Homo sapiens cytochrome P450, family...    51   6e-06
AY358977-1|AAQ89336.1|  524|Homo sapiens CYP4F12 protein.              51   6e-06
AY008841-1|AAG33247.1|  524|Homo sapiens cytochrome P450 isoform...    51   6e-06
AK127151-1|BAC86855.1|  146|Homo sapiens protein ( Homo sapiens ...    51   6e-06
AC004523-1|AAC11543.1|  458|Homo sapiens F22329_1 protein.             51   6e-06
AB035131-1|BAB18270.1|  524|Homo sapiens cytochrome P450 protein.      51   6e-06
AB035130-1|BAB18269.1|  524|Homo sapiens cytochrome P450 protein.      51   6e-06
S67581-1|AAB29503.1|  591|Homo sapiens fatty acid omega-hydroxyl...    50   8e-06
S67580-1|AAB29502.1|  519|Homo sapiens fatty acid omega-hydroxyl...    50   8e-06
BC142607-1|AAI42608.1|  455|Homo sapiens CYP4A22 protein protein.      50   1e-05
BC016853-1|AAH16853.1|  524|Homo sapiens CYP4F11 protein protein.      50   1e-05
AY280372-1|AAQ21368.1|  519|Homo sapiens cytochrome P450 4A22 pr...    50   1e-05
AF236085-1|AAG15889.1|  524|Homo sapiens CYP4F11 protein.              50   1e-05
L04751-1|AAA58436.1|  519|Homo sapiens cytochrome P450 protein.        49   2e-05
D26481-1|BAA05491.1|  519|Homo sapiens fatty acids omega-hydroxy...    49   2e-05
D13705-1|BAA02864.1|  521|Homo sapiens fatty acid omega-hydroxyl...    49   2e-05
BC041158-1|AAH41158.1|  455|Homo sapiens CYP4A11 protein protein.      49   2e-05
AY369778-1|AAQ56847.1|  519|Homo sapiens cytochrome P450, family...    49   2e-05
AY280371-1|AAQ21367.1|  519|Homo sapiens cytochrome P450 4A22K p...    49   2e-05
AL731892-4|CAH72779.1|  455|Homo sapiens cytochrome P450, family...    49   2e-05
AL731892-3|CAH72778.1|  519|Homo sapiens cytochrome P450, family...    49   2e-05
AF525488-1|AAO16078.1|  519|Homo sapiens cytochrome P450, subfam...    49   2e-05
X71480-1|CAA50586.1|  141|Homo sapiens cytochrome P450 protein.        48   4e-05
AF133298-1|AAD49566.1|  520|Homo sapiens cytochrome P450 protein.      48   4e-05
X05367-1|CAA28965.1|  521|Homo sapiens desmolase protein.              47   1e-04
M28253-1|AAA36404.1|  239|Homo sapiens cytochrome P-450-scc prot...    47   1e-04
M14565-1|AAA52162.1|  521|Homo sapiens CYP11A protein.                 47   1e-04
BC032329-1|AAH32329.1|  521|Homo sapiens cytochrome P450, family...    47   1e-04
AL135960-11|CAI19738.1|  455|Homo sapiens cytochrome P450, famil...    46   2e-04
AL135960-9|CAI19737.1|  519|Homo sapiens cytochrome P450, family...    46   2e-04
AF208532-1|AAF76722.1|  519|Homo sapiens fatty acid omega-hydrox...    46   2e-04
L16880-1|AAD13466.1|  273|Homo sapiens cytochrome P-450 2C protein.    46   2e-04
S80997-1|AAB35962.1|   44|Homo sapiens CYP2G1 homolog protein.         42   0.002
AF491285-1|AAM09532.1|  511|Homo sapiens cytochrome P450 protein.      42   0.002
X16699-1|CAA34672.1|  511|Homo sapiens protein ( Human mRNA for ...    42   0.004
J02871-1|AAA35712.1|  511|Homo sapiens protein ( Human lung cyto...    42   0.004
DQ518907-1|ABF47106.1|  511|Homo sapiens cytochrome P450, family...    42   0.004
BC017758-1|AAH17758.1|  512|Homo sapiens cytochrome P450, family...    42   0.004
AY151049-1|AAN72312.1|  497|Homo sapiens pulmonary cytochrome P4...    42   0.004
AY151048-1|AAN72311.1|  512|Homo sapiens pulmonary cytochrome P4...    42   0.004
AY064485-1|AAL57720.1|  511|Homo sapiens cytochrome P450 protein.      42   0.004
AL593856-7|CAI16982.1|  512|Homo sapiens cytochrome P450, family...    42   0.004
AL593856-6|CAI16981.1|  511|Homo sapiens cytochrome P450, family...    42   0.004
AL593856-5|CAI16983.1|  497|Homo sapiens cytochrome P450, family...    42   0.004
AL356793-4|CAI22557.1|  512|Homo sapiens cytochrome P450, family...    42   0.004
AL356793-3|CAI22559.1|  511|Homo sapiens cytochrome P450, family...    42   0.004
AL356793-2|CAI22558.1|  497|Homo sapiens cytochrome P450, family...    42   0.004
AY064486-1|AAL57721.1|  511|Homo sapiens cytochrome P450 protein.      41   0.005
BC142690-1|AAI42691.1|  357|Homo sapiens CYP4A22 protein protein.      40   0.008
AL135960-10|CAI19736.1|  421|Homo sapiens cytochrome P450, famil...    40   0.008
BC128535-1|AAI28536.1|  143|Homo sapiens CYP21A2 protein protein.      38   0.034
L36085-1|AAC01761.1|  441|Homo sapiens thromboxane A2 synthase p...    33   1.3  
DQ680079-1|ABG25922.1|  347|Homo sapiens truncated cytochrome P4...    32   2.2  
BC126134-1|AAI26135.1|  270|Homo sapiens nebulette protein.            30   8.9  
BC126132-1|AAI26133.1|  270|Homo sapiens nebulette protein.            30   8.9  
AL731547-1|CAI15775.1|  270|Homo sapiens nebulette protein.            30   8.9  
AL359175-1|CAH71371.1|  270|Homo sapiens nebulette protein.            30   8.9  
AL157398-1|CAI41189.1|  270|Homo sapiens nebulette protein.            30   8.9  
AK096540-1|BAC04812.1|  234|Homo sapiens protein ( Homo sapiens ...    30   8.9  
AJ580772-1|CAE45323.1|  270|Homo sapiens LIM-nebulette protein.        30   8.9  
AC004914-2|AAP21887.1|  311|Homo sapiens unknown protein.              30   8.9  
AC004914-1|AAD21788.1|  348|Homo sapiens unknown protein.              30   8.9  

>BC132767-1|AAI32768.1|  544|Homo sapiens cytochrome P450, family 2,
           subfamily U, polypeptide 1 protein.
          Length = 544

 Score =  151 bits (365), Expect = 4e-36
 Identities = 86/243 (35%), Positives = 135/243 (55%), Gaps = 6/243 (2%)
 Frame = +1

Query: 115 IVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGIL-NFLPFLRHFVPRLIGFT 291
           + NI+  L  G+R+D  +   KK+   + R  ++   S  +L N  P+L +++P    F 
Sbjct: 228 VSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWL-YYLP-FGPFK 285

Query: 292 ELQEIHNALHQYLREIIKEHQENLQLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXX 471
           EL++I   +  +L++IIK+HQE+L    P+D ID +L+ M E + +              
Sbjct: 286 ELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEEYLFYI 345

Query: 472 XE----AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEA 639
                 AG +T TN+ ++ LL++  N DVQ K+H+EI+ +IG +R   L D+ +M YTEA
Sbjct: 346 IGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEA 405

Query: 640 VILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGPH-WKDPXTFRPE 816
            I+E  R++ V  + IPHM   +  L  Y IPKGT IL +L+ +H  P  W+ P  F P 
Sbjct: 406 TIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPN 465

Query: 817 RFL 825
           RFL
Sbjct: 466 RFL 468


>AY343323-1|AAQ21380.1|  544|Homo sapiens cytochrome P450 protein.
          Length = 544

 Score =  151 bits (365), Expect = 4e-36
 Identities = 86/243 (35%), Positives = 135/243 (55%), Gaps = 6/243 (2%)
 Frame = +1

Query: 115 IVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGIL-NFLPFLRHFVPRLIGFT 291
           + NI+  L  G+R+D  +   KK+   + R  ++   S  +L N  P+L +++P    F 
Sbjct: 228 VSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWL-YYLP-FGPFK 285

Query: 292 ELQEIHNALHQYLREIIKEHQENLQLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXX 471
           EL++I   +  +L++IIK+HQE+L    P+D ID +L+ M E + +              
Sbjct: 286 ELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEEYLFYI 345

Query: 472 XE----AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEA 639
                 AG +T TN+ ++ LL++  N DVQ K+H+EI+ +IG +R   L D+ +M YTEA
Sbjct: 346 IGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEA 405

Query: 640 VILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGPH-WKDPXTFRPE 816
            I+E  R++ V  + IPHM   +  L  Y IPKGT IL +L+ +H  P  W+ P  F P 
Sbjct: 406 TIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPN 465

Query: 817 RFL 825
           RFL
Sbjct: 466 RFL 468


>X02612-1|CAA26458.1|  512|Homo sapiens cytochrome P(1)-450 protein.
          Length = 512

 Score =  137 bits (331), Expect = 5e-32
 Identities = 84/281 (29%), Positives = 139/281 (49%), Gaps = 9/281 (3%)
 Frame = +1

Query: 13  FMNVYIGEECEALVQLRLADAGEPILVNQMFHI--TIVNILWRLVAGKRYDLEDQRLKKL 186
           ++  ++ +E E L+         P   N   ++  ++ N++  +  G+RYD   Q L  L
Sbjct: 158 YLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSL 217

Query: 187 CSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQENL 363
            +L     ++V  SG   +F+P LR+   P L  F +L E     + ++++++KEH +  
Sbjct: 218 VNLNNNFGEVVG-SGNPADFIPILRYLPNPSLNAFKDLNE---KFYSFMQKMVKEHYKTF 273

Query: 364 QLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE-----AGMETVTNTAVFMLLHV 528
           + G  +D+ D+ +    E Q D+                    AG +TVT    + L+++
Sbjct: 274 EKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYL 333

Query: 529 VRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALND 708
           V N  VQRK+ +E+D +IGR R   L DR  + Y EA ILET R S++    IPH    D
Sbjct: 334 VMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSLVPFTIPHSTTRD 393

Query: 709 AKLGNYIIPKGTFILLSLYXLHHGPH-WKDPXTFRPERFLT 828
             L  + IPKG  + ++ + ++H    W +P  F PERFLT
Sbjct: 394 TSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLT 434


>X04300-1|CAA27843.1|  512|Homo sapiens P-450 c protein.
          Length = 512

 Score =  136 bits (329), Expect = 9e-32
 Identities = 84/281 (29%), Positives = 138/281 (49%), Gaps = 9/281 (3%)
 Frame = +1

Query: 13  FMNVYIGEECEALVQLRLADAGEPILVNQMFHI--TIVNILWRLVAGKRYDLEDQRLKKL 186
           ++  ++ +E E L+         P   N   ++  ++ N++  +  G+RYD   Q L  L
Sbjct: 158 YLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSL 217

Query: 187 CSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQENL 363
            +L     ++V  SG   +F+P LR+   P L  F +L E     + ++++++KEH +  
Sbjct: 218 VNLNNNFGEVVG-SGNPADFIPILRYLPNPSLNAFKDLNE---KFYSFMQKMVKEHYKTF 273

Query: 364 QLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE-----AGMETVTNTAVFMLLHV 528
           + G  +D+ D+ +    E Q D+                    AG +TVT    + L+++
Sbjct: 274 EKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYL 333

Query: 529 VRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALND 708
           V N  VQRK+ +E+D +IGR R   L DR  + Y EA ILET R S+     IPH    D
Sbjct: 334 VMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRD 393

Query: 709 AKLGNYIIPKGTFILLSLYXLHHGPH-WKDPXTFRPERFLT 828
             L  + IPKG  + ++ + ++H    W +P  F PERFLT
Sbjct: 394 TSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLT 434


>EF094025-1|ABK41999.1|  512|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 1 protein.
          Length = 512

 Score =  136 bits (329), Expect = 9e-32
 Identities = 84/281 (29%), Positives = 138/281 (49%), Gaps = 9/281 (3%)
 Frame = +1

Query: 13  FMNVYIGEECEALVQLRLADAGEPILVNQMFHI--TIVNILWRLVAGKRYDLEDQRLKKL 186
           ++  ++ +E E L+         P   N   ++  ++ N++  +  G+RYD   Q L  L
Sbjct: 158 YLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSL 217

Query: 187 CSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQENL 363
            +L     ++V  SG   +F+P LR+   P L  F +L E     + ++++++KEH +  
Sbjct: 218 VNLNNNFGEVVG-SGNPADFIPILRYLPNPSLNAFKDLNE---KFYSFMQKMVKEHYKTF 273

Query: 364 QLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE-----AGMETVTNTAVFMLLHV 528
           + G  +D+ D+ +    E Q D+                    AG +TVT    + L+++
Sbjct: 274 EKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYL 333

Query: 529 VRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALND 708
           V N  VQRK+ +E+D +IGR R   L DR  + Y EA ILET R S+     IPH    D
Sbjct: 334 VMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRD 393

Query: 709 AKLGNYIIPKGTFILLSLYXLHHGPH-WKDPXTFRPERFLT 828
             L  + IPKG  + ++ + ++H    W +P  F PERFLT
Sbjct: 394 TSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLT 434


>BC023019-1|AAH23019.1|  512|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 1 protein.
          Length = 512

 Score =  136 bits (329), Expect = 9e-32
 Identities = 84/281 (29%), Positives = 138/281 (49%), Gaps = 9/281 (3%)
 Frame = +1

Query: 13  FMNVYIGEECEALVQLRLADAGEPILVNQMFHI--TIVNILWRLVAGKRYDLEDQRLKKL 186
           ++  ++ +E E L+         P   N   ++  ++ N++  +  G+RYD   Q L  L
Sbjct: 158 YLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSL 217

Query: 187 CSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQENL 363
            +L     ++V  SG   +F+P LR+   P L  F +L E     + ++++++KEH +  
Sbjct: 218 VNLNNNFGEVVG-SGNPADFIPILRYLPNPSLNAFKDLNE---KFYSFMQKMVKEHYKTF 273

Query: 364 QLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE-----AGMETVTNTAVFMLLHV 528
           + G  +D+ D+ +    E Q D+                    AG +TVT    + L+++
Sbjct: 274 EKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYL 333

Query: 529 VRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALND 708
           V N  VQRK+ +E+D +IGR R   L DR  + Y EA ILET R S+     IPH    D
Sbjct: 334 VMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRD 393

Query: 709 AKLGNYIIPKGTFILLSLYXLHHGPH-WKDPXTFRPERFLT 828
             L  + IPKG  + ++ + ++H    W +P  F PERFLT
Sbjct: 394 TSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLT 434


>AK223113-1|BAD96833.1|  512|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 1 variant protein.
          Length = 512

 Score =  136 bits (329), Expect = 9e-32
 Identities = 84/281 (29%), Positives = 138/281 (49%), Gaps = 9/281 (3%)
 Frame = +1

Query: 13  FMNVYIGEECEALVQLRLADAGEPILVNQMFHI--TIVNILWRLVAGKRYDLEDQRLKKL 186
           ++  ++ +E E L+         P   N   ++  ++ N++  +  G+RYD   Q L  L
Sbjct: 158 YLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSL 217

Query: 187 CSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQENL 363
            +L     ++V  SG   +F+P LR+   P L  F +L E     + ++++++KEH +  
Sbjct: 218 VNLNNNFGEVVG-SGNPADFIPILRYLPNPSLNAFKDLNE---KFYSFMQKMVKEHYKTF 273

Query: 364 QLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE-----AGMETVTNTAVFMLLHV 528
           + G  +D+ D+ +    E Q D+                    AG +TVT    + L+++
Sbjct: 274 EKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYL 333

Query: 529 VRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALND 708
           V N  VQRK+ +E+D +IGR R   L DR  + Y EA ILET R S+     IPH    D
Sbjct: 334 VMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRD 393

Query: 709 AKLGNYIIPKGTFILLSLYXLHHGPH-WKDPXTFRPERFLT 828
             L  + IPKG  + ++ + ++H    W +P  F PERFLT
Sbjct: 394 TSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLT 434


>AF253322-1|AAK25727.1|  512|Homo sapiens cytochrome P450 protein.
          Length = 512

 Score =  136 bits (329), Expect = 9e-32
 Identities = 84/281 (29%), Positives = 138/281 (49%), Gaps = 9/281 (3%)
 Frame = +1

Query: 13  FMNVYIGEECEALVQLRLADAGEPILVNQMFHI--TIVNILWRLVAGKRYDLEDQRLKKL 186
           ++  ++ +E E L+         P   N   ++  ++ N++  +  G+RYD   Q L  L
Sbjct: 158 YLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSL 217

Query: 187 CSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQENL 363
            +L     ++V  SG   +F+P LR+   P L  F +L E     + ++++++KEH +  
Sbjct: 218 VNLNNNFGEVVG-SGNPADFIPILRYLPNPSLNAFKDLNE---KFYSFMQKMVKEHYKTF 273

Query: 364 QLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE-----AGMETVTNTAVFMLLHV 528
           + G  +D+ D+ +    E Q D+                    AG +TVT    + L+++
Sbjct: 274 EKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYL 333

Query: 529 VRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALND 708
           V N  VQRK+ +E+D +IGR R   L DR  + Y EA ILET R S+     IPH    D
Sbjct: 334 VMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRD 393

Query: 709 AKLGNYIIPKGTFILLSLYXLHHGPH-WKDPXTFRPERFLT 828
             L  + IPKG  + ++ + ++H    W +P  F PERFLT
Sbjct: 394 TSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLT 434


>K03191-1|AAA52139.1|  512|Homo sapiens CYP1A1 protein.
          Length = 512

 Score =  136 bits (328), Expect = 1e-31
 Identities = 84/281 (29%), Positives = 137/281 (48%), Gaps = 9/281 (3%)
 Frame = +1

Query: 13  FMNVYIGEECEALVQLRLADAGEPILVNQMFHI--TIVNILWRLVAGKRYDLEDQRLKKL 186
           ++  ++ +E E L+         P   N   ++  ++ N++  +  G+RYD   Q L  L
Sbjct: 158 YLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSL 217

Query: 187 CSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQENL 363
            +L     ++V  SG    F+P LR+   P L  F +L E     + ++++++KEH +  
Sbjct: 218 VNLNNNFGEVVG-SGNPAEFIPILRYLPNPSLNAFKDLNE---KFYSFMQKMVKEHYKTF 273

Query: 364 QLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE-----AGMETVTNTAVFMLLHV 528
           + G  +D+ D+ +    E Q D+                    AG +TVT    + L+++
Sbjct: 274 EKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYL 333

Query: 529 VRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALND 708
           V N  VQRK+ +E+D +IGR R   L DR  + Y EA ILET R S+     IPH    D
Sbjct: 334 VMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRD 393

Query: 709 AKLGNYIIPKGTFILLSLYXLHHGPH-WKDPXTFRPERFLT 828
             L  + IPKG  + ++ + ++H    W +P  F PERFLT
Sbjct: 394 TSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLT 434


>AK223108-1|BAD96828.1|  512|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 1 variant protein.
          Length = 512

 Score =  135 bits (326), Expect = 2e-31
 Identities = 79/247 (31%), Positives = 125/247 (50%), Gaps = 7/247 (2%)
 Frame = +1

Query: 109 ITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIG 285
           +++ N++  +  G+RYD   Q L  L +L     ++V  SG   +F+P LR+   P L  
Sbjct: 192 VSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVG-SGNPADFIPILRYLPNPSLNA 250

Query: 286 FTELQEIHNALHQYLREIIKEHQENLQLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXX 465
           F +L E     + ++++++KEH +  + G  +D+ D+ +    E Q D+           
Sbjct: 251 FKDLNE---KFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKI 307

Query: 466 XXXE-----AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVY 630
                    AG +TVT    + L+++V N  VQRK+ +E+D +IGR R   L DR  + Y
Sbjct: 308 INIVLDLFGAGFDTVTTATSWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPY 367

Query: 631 TEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGPH-WKDPXTF 807
            EA ILET R S+     IPH    D  L  + IPKG  + ++ + + H    W +P  F
Sbjct: 368 MEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQIDHDQKLWVNPSEF 427

Query: 808 RPERFLT 828
            PERFLT
Sbjct: 428 LPERFLT 434


>BC067430-1|AAH67430.1|  491|Homo sapiens cytochrome P450, family 2,
           subfamily B, polypeptide 6 protein.
          Length = 491

 Score =  133 bits (321), Expect = 9e-31
 Identities = 88/274 (32%), Positives = 136/274 (49%), Gaps = 8/274 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE + L++      G  +    +FH    NI+  +V GKR+  +DQ   K+ +L  + 
Sbjct: 146 IQEEAQCLIEELRKSKGALMDPTFLFHSITANIICSIVFGKRFHYQDQEFLKMLNLFYQT 205

Query: 208 FKLVDMSGGILN--FLPFLRHF--VPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
           F L+    G L   F  FL++F    R + +  LQEI NA   Y+   +++H+E L   A
Sbjct: 206 FSLISSVFGQLFELFSGFLKYFPGAHRQV-YKNLQEI-NA---YIGHSVEKHRETLDPSA 260

Query: 376 PKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDV 546
           P+D+ID +L+ M + + +                   AG ET + T  +  L +++   V
Sbjct: 261 PRDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHV 320

Query: 547 QRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNY 726
             ++++EI+ +IG  R   L DR +M YTEAVI E  R S +  MG+PH+         Y
Sbjct: 321 AERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGY 380

Query: 727 IIPKGTFILLSLYXLHHGPHW-KDPXTFRPERFL 825
           IIPK T + L L    H PH+ + P  F P+ FL
Sbjct: 381 IIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFL 414


>BC067431-1|AAH67431.1|  491|Homo sapiens cytochrome P450, family 2,
           subfamily B, polypeptide 6 protein.
          Length = 491

 Score =  131 bits (317), Expect = 3e-30
 Identities = 89/274 (32%), Positives = 134/274 (48%), Gaps = 8/274 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE + L++      G  +    +F     NI+  +V GKR+  +DQ   K+ +L  + 
Sbjct: 146 IQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQT 205

Query: 208 FKLVDMSGGILN--FLPFLRHF--VPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
           F L+    G L   F  FL +F    R + +  LQEI NA   Y+   +++H+E L   A
Sbjct: 206 FSLISSVFGQLFELFSGFLTYFPGAHRQV-YKNLQEI-NA---YIGHSVEKHRETLDPSA 260

Query: 376 PKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDV 546
           PKD+ID +L+ M E + +                   AG ET + T  +  L +++   V
Sbjct: 261 PKDLIDTYLLHMEEEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHV 320

Query: 547 QRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNY 726
             ++++EI+ +IG  R   L DR +M YTEAVI E  R S +  MG+PH+         Y
Sbjct: 321 AERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGY 380

Query: 727 IIPKGTFILLSLYXLHHGPHW-KDPXTFRPERFL 825
           IIPK T + L L    H PH+ + P  F P+ FL
Sbjct: 381 IIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFL 414


>M29874-1|AAA52144.1|  491|Homo sapiens CYP2B protein.
          Length = 491

 Score =  131 bits (316), Expect = 3e-30
 Identities = 88/274 (32%), Positives = 135/274 (49%), Gaps = 8/274 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE + L++      G  +    +F     NI+  +V GKR+  +DQ   K+ +L  + 
Sbjct: 146 IQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQT 205

Query: 208 FKLVDMSGGILN--FLPFLRHF--VPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
           F L+    G L   F  FL++F    R + +  LQEI NA   Y+   +++H+E L   A
Sbjct: 206 FSLISSVFGQLFELFSGFLKYFPGAHRQV-YKNLQEI-NA---YIGHSVEKHRETLDPSA 260

Query: 376 PKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDV 546
           PKD+ID +L+ M + + +                   AG ET + T  +  L +++   V
Sbjct: 261 PKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHV 320

Query: 547 QRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNY 726
             ++++EI+ +IG  R   L DR +M YTEAVI E  R S +  MG+PH+         Y
Sbjct: 321 AERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGY 380

Query: 727 IIPKGTFILLSLYXLHHGPHW-KDPXTFRPERFL 825
           IIPK T + L L    H PH+ + P  F P+ FL
Sbjct: 381 IIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFL 414


>DQ298753-1|ABB84469.1|  491|Homo sapiens cytochrome P450, family 2,
           subfamily B, polypeptide 6 protein.
          Length = 491

 Score =  131 bits (316), Expect = 3e-30
 Identities = 88/274 (32%), Positives = 135/274 (49%), Gaps = 8/274 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE + L++      G  +    +F     NI+  +V GKR+  +DQ   K+ +L  + 
Sbjct: 146 IQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQT 205

Query: 208 FKLVDMSGGILN--FLPFLRHF--VPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
           F L+    G L   F  FL++F    R + +  LQEI NA   Y+   +++H+E L   A
Sbjct: 206 FSLISSVFGQLFELFSGFLKYFPGAHRQV-YKNLQEI-NA---YIGHSVEKHRETLDPSA 260

Query: 376 PKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDV 546
           PKD+ID +L+ M + + +                   AG ET + T  +  L +++   V
Sbjct: 261 PKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHV 320

Query: 547 QRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNY 726
             ++++EI+ +IG  R   L DR +M YTEAVI E  R S +  MG+PH+         Y
Sbjct: 321 AERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGY 380

Query: 727 IIPKGTFILLSLYXLHHGPHW-KDPXTFRPERFL 825
           IIPK T + L L    H PH+ + P  F P+ FL
Sbjct: 381 IIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFL 414


>AC023172-1|AAF32444.1|  491|Homo sapiens CYP2B6 protein.
          Length = 491

 Score =  131 bits (316), Expect = 3e-30
 Identities = 88/274 (32%), Positives = 135/274 (49%), Gaps = 8/274 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE + L++      G  +    +F     NI+  +V GKR+  +DQ   K+ +L  + 
Sbjct: 146 IQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQT 205

Query: 208 FKLVDMSGGILN--FLPFLRHF--VPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
           F L+    G L   F  FL++F    R + +  LQEI NA   Y+   +++H+E L   A
Sbjct: 206 FSLISSVFGQLFELFSGFLKYFPGAHRQV-YKNLQEI-NA---YIGHSVEKHRETLDPSA 260

Query: 376 PKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDV 546
           PKD+ID +L+ M + + +                   AG ET + T  +  L +++   V
Sbjct: 261 PKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHV 320

Query: 547 QRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNY 726
             ++++EI+ +IG  R   L DR +M YTEAVI E  R S +  MG+PH+         Y
Sbjct: 321 AERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGY 380

Query: 727 IIPKGTFILLSLYXLHHGPHW-KDPXTFRPERFL 825
           IIPK T + L L    H PH+ + P  F P+ FL
Sbjct: 381 IIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFL 414


>AF182277-1|AAF13602.1|  491|Homo sapiens cytochrome P450-2B6
           protein.
          Length = 491

 Score =  130 bits (315), Expect = 5e-30
 Identities = 80/270 (29%), Positives = 131/270 (48%), Gaps = 6/270 (2%)
 Frame = +1

Query: 34  EECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFK 213
           EE + L++      G  +    +FH    NI+  +V GKR+  +DQ   K+ +L  + F 
Sbjct: 148 EEAQCLIEELRKSKGALMDATFLFHSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFS 207

Query: 214 LVDMSGGILN--FLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKDV 387
           L+    G L   F  FL++F        ++ +    ++ Y+   +++H+E L   AP+D+
Sbjct: 208 LISSVFGQLFELFSGFLKYFPG---AHRQVYKNPQEINAYIGHSVEKHRETLDPSAPRDL 264

Query: 388 IDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQRKL 558
           ID +L+ M + + +                   AG ET + T  +  L +++   V  ++
Sbjct: 265 IDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERV 324

Query: 559 HQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPK 738
           ++EI+ +IG  R   L DR +M YTEAVI E  R S +  MG+PH+         YIIPK
Sbjct: 325 YREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPK 384

Query: 739 GTFILLSLYXLHHGPHW-KDPXTFRPERFL 825
            T + L L    H PH+ + P  F P+ FL
Sbjct: 385 DTEVFLILSTALHDPHYFEKPDAFNPDHFL 414


>Y00498-1|CAA68550.1|  490|Homo sapiens IIC2 protein.
          Length = 490

 Score =  128 bits (309), Expect = 2e-29
 Identities = 84/273 (30%), Positives = 129/273 (47%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           + EE   LV+        P     +      N++  +V  KR+D +DQ    L       
Sbjct: 145 VQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNEN 204

Query: 208 FKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNAL--HQYLREIIKEHQENLQLGAP 378
           F++++     + N  P L    P     T  + + N      Y+RE +KEHQ +L +  P
Sbjct: 205 FRILNSPWIQVCNNFPLLIDCFPG----THNKVLKNVALTRSYIREKVKEHQASLDVNNP 260

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D ID FLI M + +D++              +   AG ET + T  + LL ++++ +V 
Sbjct: 261 RDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVT 320

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            K+ +EID +IGR R+  + DR  M YT+AV+ E  R S +   G+PH    D K  NY+
Sbjct: 321 AKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYL 380

Query: 730 IPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           IPKGT I+  L   LH    + +P  F P  FL
Sbjct: 381 IPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFL 413


>M21941-1|AAA52160.1|  480|Homo sapiens CYP2C protein.
          Length = 480

 Score =  128 bits (309), Expect = 2e-29
 Identities = 84/273 (30%), Positives = 130/273 (47%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           + EE   LV+        P     +      N++  +V  KR+D +DQ+   L       
Sbjct: 135 VQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQKFLTLMKRFNEN 194

Query: 208 FKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNAL--HQYLREIIKEHQENLQLGAP 378
           F++++     + N  P L    P     T  + + N      Y+RE +KEHQ +L +  P
Sbjct: 195 FRILNSPWIQVCNNFPLLIDCFPG----THNKVLKNVALTRSYIREKVKEHQASLDVNNP 250

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D ID FLI M + +D++              +   AG ET + T  + LL ++++ +V 
Sbjct: 251 RDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVT 310

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            K+ +EID +IGR R+  + DR  M YT+AV+ E  R S +   G+PH    D K  NY+
Sbjct: 311 AKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYL 370

Query: 730 IPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           IPKGT I+  L   LH    + +P  F P  FL
Sbjct: 371 IPKGTTIMALLTSVLHDDKEFPNPNIFDPGLFL 403


>BC020596-1|AAH20596.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 8 protein.
          Length = 490

 Score =  128 bits (309), Expect = 2e-29
 Identities = 84/273 (30%), Positives = 129/273 (47%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           + EE   LV+        P     +      N++  +V  KR+D +DQ    L       
Sbjct: 145 VQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNEN 204

Query: 208 FKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNAL--HQYLREIIKEHQENLQLGAP 378
           F++++     + N  P L    P     T  + + N      Y+RE +KEHQ +L +  P
Sbjct: 205 FRILNSPWIQVCNNFPLLIDCFPG----THNKVLKNVALTRSYIREKVKEHQASLDVNNP 260

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D ID FLI M + +D++              +   AG ET + T  + LL ++++ +V 
Sbjct: 261 RDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVT 320

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            K+ +EID +IGR R+  + DR  M YT+AV+ E  R S +   G+PH    D K  NY+
Sbjct: 321 AKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYL 380

Query: 730 IPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           IPKGT I+  L   LH    + +P  F P  FL
Sbjct: 381 IPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFL 413


>AY514490-1|AAR89907.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 8 protein.
          Length = 490

 Score =  128 bits (309), Expect = 2e-29
 Identities = 84/273 (30%), Positives = 129/273 (47%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           + EE   LV+        P     +      N++  +V  KR+D +DQ    L       
Sbjct: 145 VQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNEN 204

Query: 208 FKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNAL--HQYLREIIKEHQENLQLGAP 378
           F++++     + N  P L    P     T  + + N      Y+RE +KEHQ +L +  P
Sbjct: 205 FRILNSPWIQVCNNFPLLIDCFPG----THNKVLKNVALTRSYIREKVKEHQASLDVNNP 260

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D ID FLI M + +D++              +   AG ET + T  + LL ++++ +V 
Sbjct: 261 RDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVT 320

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            K+ +EID +IGR R+  + DR  M YT+AV+ E  R S +   G+PH    D K  NY+
Sbjct: 321 AKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYL 380

Query: 730 IPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           IPKGT I+  L   LH    + +P  F P  FL
Sbjct: 381 IPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFL 413


>AL359672-5|CAH71307.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 8 protein.
          Length = 490

 Score =  128 bits (309), Expect = 2e-29
 Identities = 84/273 (30%), Positives = 129/273 (47%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           + EE   LV+        P     +      N++  +V  KR+D +DQ    L       
Sbjct: 145 VQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNEN 204

Query: 208 FKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNAL--HQYLREIIKEHQENLQLGAP 378
           F++++     + N  P L    P     T  + + N      Y+RE +KEHQ +L +  P
Sbjct: 205 FRILNSPWIQVCNNFPLLIDCFPG----THNKVLKNVALTRSYIREKVKEHQASLDVNNP 260

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D ID FLI M + +D++              +   AG ET + T  + LL ++++ +V 
Sbjct: 261 RDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVT 320

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            K+ +EID +IGR R+  + DR  M YT+AV+ E  R S +   G+PH    D K  NY+
Sbjct: 321 AKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYL 380

Query: 730 IPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           IPKGT I+  L   LH    + +P  F P  FL
Sbjct: 381 IPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFL 413


>M17397-1|AAA35739.1|  490|Homo sapiens protein ( Human cytochrome
           P-450 1 functional form mRNA, complete cds. ).
          Length = 490

 Score =  127 bits (306), Expect = 6e-29
 Identities = 83/273 (30%), Positives = 129/273 (47%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           + EE   LV+        P     +      N++  +V  KR+D +DQ    L       
Sbjct: 145 VQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNEN 204

Query: 208 FKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNAL--HQYLREIIKEHQENLQLGAP 378
           F++++     + N  P L    P     T  + + N      Y+RE +KEHQ +L +  P
Sbjct: 205 FRILNSPWIQVCNNFPLLIDCFPG----THNKVLKNVALTRSYIREKVKEHQASLDVNNP 260

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D +D FLI M + +D++              +   AG ET + T  + LL ++++ +V 
Sbjct: 261 RDFMDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVT 320

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            K+ +EID +IGR R+  + DR  M YT+AV+ E  R S +   G+PH    D K  NY+
Sbjct: 321 AKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYL 380

Query: 730 IPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           IPKGT I+  L   LH    + +P  F P  FL
Sbjct: 381 IPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFL 413


>M21942-1|AAA52161.1|  462|Homo sapiens CYP2C protein.
          Length = 462

 Score =  126 bits (304), Expect = 1e-28
 Identities = 78/242 (32%), Positives = 121/242 (50%), Gaps = 7/242 (2%)
 Frame = +1

Query: 121 NILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSG-GILNFLPFLRHFVPRLIGFTEL 297
           N++  +V  KR+D +DQ    L       F++++     + N  P L    P     T  
Sbjct: 148 NVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPG----THN 203

Query: 298 QEIHNAL--HQYLREIIKEHQENLQLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXX 471
           + + N      Y+RE ++EHQ +L +  P+D ID FLI M + +D++             
Sbjct: 204 KVLKNVALTRSYIREKVREHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTV 263

Query: 472 XE---AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAV 642
            +   AG ET + T  + LL ++++ +V  K+ +EID +IGR R+  + DR  M YT+AV
Sbjct: 264 ADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAV 323

Query: 643 ILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYX-LHHGPHWKDPXTFRPER 819
           + E  R S +   G+PH    D K  NY+IPKGT I+  L   LH    + +P  F P  
Sbjct: 324 VHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGH 383

Query: 820 FL 825
           FL
Sbjct: 384 FL 385


>X65962-1|CAA46778.1|  356|Homo sapiens cytochrome P-450 II C
           protein.
          Length = 356

 Score =  125 bits (301), Expect = 2e-28
 Identities = 82/273 (30%), Positives = 129/273 (47%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           + EE   LV+        P     +      N++  +V  KR+D +DQ    L       
Sbjct: 11  VQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNEN 70

Query: 208 FKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNAL--HQYLREIIKEHQENLQLGAP 378
           F++++     + N  P L    P     T  + + N      Y+RE +KEHQ +L +  P
Sbjct: 71  FRILNSPWIQVCNNFPLLIDCFPG----THNKVLKNVALTRSYIREKVKEHQASLDVNNP 126

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D ID FLI M + +D++              +   AG ET + T  + LL ++++ +V 
Sbjct: 127 RDFIDCFLIKMEQEKDNQKSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVT 186

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            K+ +EI+ ++GR+R+  + DR  M YT+AV+ E  R   +    +PH    D K  NY+
Sbjct: 187 AKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDIKFRNYL 246

Query: 730 IPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           IPKGT IL SL   LH    + +P  F P  FL
Sbjct: 247 IPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFL 279


>AY513608-1|AAR90939.1|  494|Homo sapiens cytochrome P450 2A13
           variant 5 protein.
          Length = 494

 Score =  124 bits (300), Expect = 3e-28
 Identities = 81/273 (29%), Positives = 132/273 (48%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE   L++      G  I        T+ N++  +V G R+D ED+    L  +++  
Sbjct: 149 IQEEAGFLIEALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGS 208

Query: 208 FKLVDMSGGILN--FLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAP 378
           F+    S G L   F   ++H   P+   F ELQ     L  ++ + ++ +Q  L   +P
Sbjct: 209 FQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQ----GLEDFIAKKVEHNQRTLDPNSP 264

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D ID+FLI M E + +                   AG ETV+ T  +  L ++++ +V+
Sbjct: 265 RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVE 324

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            K+H+EID +IG++R    +DR +M YTEAVI E  R   +  MG+ H    D K  ++ 
Sbjct: 325 AKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFF 384

Query: 730 IPKGTFILLSLYXLHHGPH-WKDPXTFRPERFL 825
           +PKGT +   L  +   P  + +P  F P+ FL
Sbjct: 385 LPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFL 417


>M61858-1|AAA52145.1|  370|Homo sapiens CYP2C17 protein.
          Length = 370

 Score =  124 bits (299), Expect = 4e-28
 Identities = 83/272 (30%), Positives = 132/272 (48%), Gaps = 6/272 (2%)
 Frame = +1

Query: 28  IGEECEALVQ-LRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           + EE   LV+ LR  +A  P     +      N++  ++  KR+D +DQ+   L   +  
Sbjct: 25  VQEEARCLVEELRKTNAS-PCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNE 83

Query: 205 LFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPK 381
             ++V      I N    +  + P      +L +    L  Y+ E IKEHQE+L +  P+
Sbjct: 84  NIRIVSTPWIQICNNFSTIIDYFPG--SHNKLLKNLLTLKSYVLERIKEHQESLDMNNPR 141

Query: 382 DVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQR 552
           D ID FLI M + + ++              +   AG ET + T  + LL ++++ +V  
Sbjct: 142 DFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYALLLLLKHPEVTA 201

Query: 553 KLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYII 732
           K+ +EI+ ++GR+R+  + DR  M YT+AV+ E  R   +    +PH    D K  NY+I
Sbjct: 202 KVQEEIERVVGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLI 261

Query: 733 PKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           PKGT IL SL   LH    + +P  F P  FL
Sbjct: 262 PKGTTILTSLTSVLHDNKEFPNPEMFDPRHFL 293


>M33388-1|AAA53500.1|  497|Homo sapiens cytochrome P450 IID6
           protein.
          Length = 497

 Score =  124 bits (298), Expect = 5e-28
 Identities = 82/275 (29%), Positives = 133/275 (48%), Gaps = 8/275 (2%)
 Frame = +1

Query: 25  YIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           ++ EE   L       +G P   N +    + N++  L  G+R++ +D R  +L  L   
Sbjct: 152 WVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE 211

Query: 205 LFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
             K  + SG    +LN +P L H +P L G  ++     A    L E++ EH+       
Sbjct: 212 GLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQ 266

Query: 376 P-KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNED 543
           P +D+ +AFL +M +++ +               +   AGM T + T  + LL ++ + D
Sbjct: 267 PPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPD 326

Query: 544 VQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGN 723
           VQR++ QEIDD+IG+ R   + D+  M YT AVI E  R   +  +G+ HM   D ++  
Sbjct: 327 VQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQG 386

Query: 724 YIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           + IPKGT ++ +L   L     W+ P  F PE FL
Sbjct: 387 FRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 421


>M24499-1|AAA36403.1|  373|Homo sapiens cytochrome P450db1 protein.
          Length = 373

 Score =  124 bits (298), Expect = 5e-28
 Identities = 82/275 (29%), Positives = 133/275 (48%), Gaps = 8/275 (2%)
 Frame = +1

Query: 25  YIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           ++ EE   L       +G P   N +    + N++  L  G+R++ +D R  +L  L   
Sbjct: 28  WVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE 87

Query: 205 LFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
             K  + SG    +LN +P L H +P L G  ++     A    L E++ EH+       
Sbjct: 88  GLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQ 142

Query: 376 P-KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNED 543
           P +D+ +AFL +M +++ +               +   AGM T + T  + LL ++ + D
Sbjct: 143 PPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPD 202

Query: 544 VQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGN 723
           VQR++ QEIDD+IG+ R   + D+  M YT AVI E  R   +  +G+ HM   D ++  
Sbjct: 203 VQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQG 262

Query: 724 YIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           + IPKGT ++ +L   L     W+ P  F PE FL
Sbjct: 263 FRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 297


>DQ282154-1|ABB77902.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  124 bits (298), Expect = 5e-28
 Identities = 82/275 (29%), Positives = 133/275 (48%), Gaps = 8/275 (2%)
 Frame = +1

Query: 25  YIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           ++ EE   L       +G P   N +    + N++  L  G+R++ +D R  +L  L   
Sbjct: 152 WVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE 211

Query: 205 LFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
             K  + SG    +LN +P L H +P L G  ++     A    L E++ EH+       
Sbjct: 212 GLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQ 266

Query: 376 P-KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNED 543
           P +D+ +AFL +M +++ +               +   AGM T + T  + LL ++ + D
Sbjct: 267 PPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPD 326

Query: 544 VQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGN 723
           VQR++ QEIDD+IG+ R   + D+  M YT AVI E  R   +  +G+ HM   D ++  
Sbjct: 327 VQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQG 386

Query: 724 YIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           + IPKGT ++ +L   L     W+ P  F PE FL
Sbjct: 387 FRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 421


>DQ282152-1|ABB77900.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  124 bits (298), Expect = 5e-28
 Identities = 82/275 (29%), Positives = 133/275 (48%), Gaps = 8/275 (2%)
 Frame = +1

Query: 25  YIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           ++ EE   L       +G P   N +    + N++  L  G+R++ +D R  +L  L   
Sbjct: 152 WVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE 211

Query: 205 LFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
             K  + SG    +LN +P L H +P L G  ++     A    L E++ EH+       
Sbjct: 212 GLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQ 266

Query: 376 P-KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNED 543
           P +D+ +AFL +M +++ +               +   AGM T + T  + LL ++ + D
Sbjct: 267 PPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPD 326

Query: 544 VQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGN 723
           VQR++ QEIDD+IG+ R   + D+  M YT AVI E  R   +  +G+ HM   D ++  
Sbjct: 327 VQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQG 386

Query: 724 YIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           + IPKGT ++ +L   L     W+ P  F PE FL
Sbjct: 387 FRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 421


>DQ282146-1|ABB77897.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  124 bits (298), Expect = 5e-28
 Identities = 82/275 (29%), Positives = 133/275 (48%), Gaps = 8/275 (2%)
 Frame = +1

Query: 25  YIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           ++ EE   L       +G P   N +    + N++  L  G+R++ +D R  +L  L   
Sbjct: 152 WVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE 211

Query: 205 LFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
             K  + SG    +LN +P L H +P L G  ++     A    L E++ EH+       
Sbjct: 212 GLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQ 266

Query: 376 P-KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNED 543
           P +D+ +AFL +M +++ +               +   AGM T + T  + LL ++ + D
Sbjct: 267 PPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPD 326

Query: 544 VQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGN 723
           VQR++ QEIDD+IG+ R   + D+  M YT AVI E  R   +  +G+ HM   D ++  
Sbjct: 327 VQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQG 386

Query: 724 YIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           + IPKGT ++ +L   L     W+ P  F PE FL
Sbjct: 387 FRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 421


>DQ282145-1|ABB77896.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  124 bits (298), Expect = 5e-28
 Identities = 82/275 (29%), Positives = 133/275 (48%), Gaps = 8/275 (2%)
 Frame = +1

Query: 25  YIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           ++ EE   L       +G P   N +    + N++  L  G+R++ +D R  +L  L   
Sbjct: 152 WVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE 211

Query: 205 LFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
             K  + SG    +LN +P L H +P L G  ++     A    L E++ EH+       
Sbjct: 212 GLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQ 266

Query: 376 P-KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNED 543
           P +D+ +AFL +M +++ +               +   AGM T + T  + LL ++ + D
Sbjct: 267 PPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPD 326

Query: 544 VQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGN 723
           VQR++ QEIDD+IG+ R   + D+  M YT AVI E  R   +  +G+ HM   D ++  
Sbjct: 327 VQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQG 386

Query: 724 YIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           + IPKGT ++ +L   L     W+ P  F PE FL
Sbjct: 387 FRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 421


>DQ282144-1|ABB77895.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  124 bits (298), Expect = 5e-28
 Identities = 82/275 (29%), Positives = 133/275 (48%), Gaps = 8/275 (2%)
 Frame = +1

Query: 25  YIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           ++ EE   L       +G P   N +    + N++  L  G+R++ +D R  +L  L   
Sbjct: 152 WVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE 211

Query: 205 LFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
             K  + SG    +LN +P L H +P L G  ++     A    L E++ EH+       
Sbjct: 212 GLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQ 266

Query: 376 P-KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNED 543
           P +D+ +AFL +M +++ +               +   AGM T + T  + LL ++ + D
Sbjct: 267 PPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPD 326

Query: 544 VQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGN 723
           VQR++ QEIDD+IG+ R   + D+  M YT AVI E  R   +  +G+ HM   D ++  
Sbjct: 327 VQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQG 386

Query: 724 YIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           + IPKGT ++ +L   L     W+ P  F PE FL
Sbjct: 387 FRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 421


>DQ211354-2|ABB01372.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  124 bits (298), Expect = 5e-28
 Identities = 82/275 (29%), Positives = 133/275 (48%), Gaps = 8/275 (2%)
 Frame = +1

Query: 25  YIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           ++ EE   L       +G P   N +    + N++  L  G+R++ +D R  +L  L   
Sbjct: 152 WVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE 211

Query: 205 LFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
             K  + SG    +LN +P L H +P L G  ++     A    L E++ EH+       
Sbjct: 212 GLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQ 266

Query: 376 P-KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNED 543
           P +D+ +AFL +M +++ +               +   AGM T + T  + LL ++ + D
Sbjct: 267 PPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPD 326

Query: 544 VQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGN 723
           VQR++ QEIDD+IG+ R   + D+  M YT AVI E  R   +  +G+ HM   D ++  
Sbjct: 327 VQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQG 386

Query: 724 YIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           + IPKGT ++ +L   L     W+ P  F PE FL
Sbjct: 387 FRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 421


>DQ211353-2|ABB01371.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  124 bits (298), Expect = 5e-28
 Identities = 82/275 (29%), Positives = 133/275 (48%), Gaps = 8/275 (2%)
 Frame = +1

Query: 25  YIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           ++ EE   L       +G P   N +    + N++  L  G+R++ +D R  +L  L   
Sbjct: 152 WVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE 211

Query: 205 LFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
             K  + SG    +LN +P L H +P L G  ++     A    L E++ EH+       
Sbjct: 212 GLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQ 266

Query: 376 P-KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNED 543
           P +D+ +AFL +M +++ +               +   AGM T + T  + LL ++ + D
Sbjct: 267 PPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPD 326

Query: 544 VQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGN 723
           VQR++ QEIDD+IG+ R   + D+  M YT AVI E  R   +  +G+ HM   D ++  
Sbjct: 327 VQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQG 386

Query: 724 YIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           + IPKGT ++ +L   L     W+ P  F PE FL
Sbjct: 387 FRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 421


>DQ211353-1|ABB01370.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  124 bits (298), Expect = 5e-28
 Identities = 82/275 (29%), Positives = 133/275 (48%), Gaps = 8/275 (2%)
 Frame = +1

Query: 25  YIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           ++ EE   L       +G P   N +    + N++  L  G+R++ +D R  +L  L   
Sbjct: 152 WVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE 211

Query: 205 LFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
             K  + SG    +LN +P L H +P L G  ++     A    L E++ EH+       
Sbjct: 212 GLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQ 266

Query: 376 P-KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNED 543
           P +D+ +AFL +M +++ +               +   AGM T + T  + LL ++ + D
Sbjct: 267 PPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPD 326

Query: 544 VQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGN 723
           VQR++ QEIDD+IG+ R   + D+  M YT AVI E  R   +  +G+ HM   D ++  
Sbjct: 327 VQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQG 386

Query: 724 YIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           + IPKGT ++ +L   L     W+ P  F PE FL
Sbjct: 387 FRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 421


>BC075024-1|AAH75024.1|  497|Homo sapiens cytochrome P450, family 2,
           subfamily D, polypeptide 6 protein.
          Length = 497

 Score =  124 bits (298), Expect = 5e-28
 Identities = 82/275 (29%), Positives = 133/275 (48%), Gaps = 8/275 (2%)
 Frame = +1

Query: 25  YIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           ++ EE   L       +G P   N +    + N++  L  G+R++ +D R  +L  L   
Sbjct: 152 WVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE 211

Query: 205 LFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
             K  + SG    +LN +P L H +P L G  ++     A    L E++ EH+       
Sbjct: 212 GLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQ 266

Query: 376 P-KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNED 543
           P +D+ +AFL +M +++ +               +   AGM T + T  + LL ++ + D
Sbjct: 267 PPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPD 326

Query: 544 VQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGN 723
           VQR++ QEIDD+IG+ R   + D+  M YT AVI E  R   +  +G+ HM   D ++  
Sbjct: 327 VQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQG 386

Query: 724 YIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           + IPKGT ++ +L   L     W+ P  F PE FL
Sbjct: 387 FRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 421


>BC075023-1|AAH75023.1|  497|Homo sapiens cytochrome P450, family 2,
           subfamily D, polypeptide 6 protein.
          Length = 497

 Score =  124 bits (298), Expect = 5e-28
 Identities = 82/275 (29%), Positives = 133/275 (48%), Gaps = 8/275 (2%)
 Frame = +1

Query: 25  YIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           ++ EE   L       +G P   N +    + N++  L  G+R++ +D R  +L  L   
Sbjct: 152 WVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE 211

Query: 205 LFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
             K  + SG    +LN +P L H +P L G  ++     A    L E++ EH+       
Sbjct: 212 GLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQ 266

Query: 376 P-KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNED 543
           P +D+ +AFL +M +++ +               +   AGM T + T  + LL ++ + D
Sbjct: 267 PPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPD 326

Query: 544 VQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGN 723
           VQR++ QEIDD+IG+ R   + D+  M YT AVI E  R   +  +G+ HM   D ++  
Sbjct: 327 VQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQG 386

Query: 724 YIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           + IPKGT ++ +L   L     W+ P  F PE FL
Sbjct: 387 FRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 421


>AY545216-1|AAS55001.1|  497|Homo sapiens cytochrome P4502D6
           protein.
          Length = 497

 Score =  124 bits (298), Expect = 5e-28
 Identities = 82/275 (29%), Positives = 133/275 (48%), Gaps = 8/275 (2%)
 Frame = +1

Query: 25  YIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           ++ EE   L       +G P   N +    + N++  L  G+R++ +D R  +L  L   
Sbjct: 152 WVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE 211

Query: 205 LFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
             K  + SG    +LN +P L H +P L G  ++     A    L E++ EH+       
Sbjct: 212 GLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQ 266

Query: 376 P-KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNED 543
           P +D+ +AFL +M +++ +               +   AGM T + T  + LL ++ + D
Sbjct: 267 PPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPD 326

Query: 544 VQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGN 723
           VQR++ QEIDD+IG+ R   + D+  M YT AVI E  R   +  +G+ HM   D ++  
Sbjct: 327 VQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQG 386

Query: 724 YIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           + IPKGT ++ +L   L     W+ P  F PE FL
Sbjct: 387 FRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 421


>AY513606-1|AAR90937.1|  494|Homo sapiens cytochrome P450 2A13
           variant 3 protein.
          Length = 494

 Score =  124 bits (298), Expect = 5e-28
 Identities = 81/273 (29%), Positives = 131/273 (47%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE   L+       G  I        T+ N++  +V G R+D ED+    L  +++  
Sbjct: 149 IQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGS 208

Query: 208 FKLVDMSGGILN--FLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAP 378
           F+    S G L   F   ++H   P+   F ELQ     L  ++ + ++ +Q  L   +P
Sbjct: 209 FQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQ----GLEDFIAKKVEHNQRTLDPNSP 264

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D ID+FLI M E + +                   AG ETV+ T  +  L ++++ +V+
Sbjct: 265 RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVE 324

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            K+H+EID +IG++R    +DR +M YTEAVI E  R   +  MG+ H    D K  ++ 
Sbjct: 325 AKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFF 384

Query: 730 IPKGTFILLSLYXLHHGPH-WKDPXTFRPERFL 825
           +PKGT +   L  +   P  + +P  F P+ FL
Sbjct: 385 LPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFL 417


>AY513605-1|AAR90936.1|  494|Homo sapiens cytochrome P450 2A13
           variant 2 protein.
          Length = 494

 Score =  124 bits (298), Expect = 5e-28
 Identities = 81/273 (29%), Positives = 131/273 (47%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE   L+       G  I        T+ N++  +V G R+D ED+    L  +++  
Sbjct: 149 IQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGS 208

Query: 208 FKLVDMSGGILN--FLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAP 378
           F+    S G L   F   ++H   P+   F ELQ     L  ++ + ++ +Q  L   +P
Sbjct: 209 FQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQ----GLEDFIAKKVEHNQRTLDPNSP 264

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D ID+FLI M E + +                   AG ETV+ T  +  L ++++ +V+
Sbjct: 265 RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVE 324

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            K+H+EID +IG++R    +DR +M YTEAVI E  R   +  MG+ H    D K  ++ 
Sbjct: 325 AKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFF 384

Query: 730 IPKGTFILLSLYXLHHGPH-WKDPXTFRPERFL 825
           +PKGT +   L  +   P  + +P  F P+ FL
Sbjct: 385 LPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFL 417


>AY513604-1|AAR90935.1|  494|Homo sapiens cytochrome P450 2A13
           variant 1 protein.
          Length = 494

 Score =  124 bits (298), Expect = 5e-28
 Identities = 81/273 (29%), Positives = 131/273 (47%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE   L+       G  I        T+ N++  +V G R+D ED+    L  +++  
Sbjct: 149 IQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGS 208

Query: 208 FKLVDMSGGILN--FLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAP 378
           F+    S G L   F   ++H   P+   F ELQ     L  ++ + ++ +Q  L   +P
Sbjct: 209 FQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQ----GLEDFIAKKVEHNQRTLDPNSP 264

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D ID+FLI M E + +                   AG ETV+ T  +  L ++++ +V+
Sbjct: 265 RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVE 324

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            K+H+EID +IG++R    +DR +M YTEAVI E  R   +  MG+ H    D K  ++ 
Sbjct: 325 AKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFF 384

Query: 730 IPKGTFILLSLYXLHHGPH-WKDPXTFRPERFL 825
           +PKGT +   L  +   P  + +P  F P+ FL
Sbjct: 385 LPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFL 417


>AF209774-1|AAG35775.1|  494|Homo sapiens cytochrome P450 2A13
           protein.
          Length = 494

 Score =  124 bits (298), Expect = 5e-28
 Identities = 81/273 (29%), Positives = 131/273 (47%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE   L+       G  I        T+ N++  +V G R+D ED+    L  +++  
Sbjct: 149 IQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGS 208

Query: 208 FKLVDMSGGILN--FLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAP 378
           F+    S G L   F   ++H   P+   F ELQ     L  ++ + ++ +Q  L   +P
Sbjct: 209 FQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQ----GLEDFIAKKVEHNQRTLDPNSP 264

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D ID+FLI M E + +                   AG ETV+ T  +  L ++++ +V+
Sbjct: 265 RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVE 324

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            K+H+EID +IG++R    +DR +M YTEAVI E  R   +  MG+ H    D K  ++ 
Sbjct: 325 AKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFF 384

Query: 730 IPKGTFILLSLYXLHHGPH-WKDPXTFRPERFL 825
           +PKGT +   L  +   P  + +P  F P+ FL
Sbjct: 385 LPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFL 417


>DQ282160-1|ABB77908.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  123 bits (297), Expect = 7e-28
 Identities = 82/275 (29%), Positives = 133/275 (48%), Gaps = 8/275 (2%)
 Frame = +1

Query: 25  YIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           ++ EE   L       +G P   N +    + N++  L  G+R++ +D R  +L  L   
Sbjct: 152 WVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE 211

Query: 205 LFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
             K  + SG    +LN +P L H +P L G  ++     A    L E++ EH+       
Sbjct: 212 GLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQ 266

Query: 376 P-KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNED 543
           P +D+ +AFL +M +++ +               +   AGM T + T  + LL ++ + D
Sbjct: 267 PPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPD 326

Query: 544 VQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGN 723
           VQR++ QEIDD+IG+ R   + D+  M YT AVI E  R   +  +G+ HM   D ++  
Sbjct: 327 VQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQG 386

Query: 724 YIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           + IPKGT ++ +L   L     W+ P  F PE FL
Sbjct: 387 FRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 421


>DQ282159-1|ABB77907.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  123 bits (297), Expect = 7e-28
 Identities = 82/275 (29%), Positives = 133/275 (48%), Gaps = 8/275 (2%)
 Frame = +1

Query: 25  YIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           ++ EE   L       +G P   N +    + N++  L  G+R++ +D R  +L  L   
Sbjct: 152 WVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE 211

Query: 205 LFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
             K  + SG    +LN +P L H +P L G  ++     A    L E++ EH+       
Sbjct: 212 GLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQ 266

Query: 376 P-KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNED 543
           P +D+ +AFL +M +++ +               +   AGM T + T  + LL ++ + D
Sbjct: 267 PPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPD 326

Query: 544 VQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGN 723
           VQR++ QEIDD+IG+ R   + D+  M YT AVI E  R   +  +G+ HM   D ++  
Sbjct: 327 VQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQG 386

Query: 724 YIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           + IPKGT ++ +L   L     W+ P  F PE FL
Sbjct: 387 FRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 421


>DQ282158-1|ABB77906.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  123 bits (297), Expect = 7e-28
 Identities = 82/275 (29%), Positives = 133/275 (48%), Gaps = 8/275 (2%)
 Frame = +1

Query: 25  YIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           ++ EE   L       +G P   N +    + N++  L  G+R++ +D R  +L  L   
Sbjct: 152 WVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE 211

Query: 205 LFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
             K  + SG    +LN +P L H +P L G  ++     A    L E++ EH+       
Sbjct: 212 GLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQ 266

Query: 376 P-KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNED 543
           P +D+ +AFL +M +++ +               +   AGM T + T  + LL ++ + D
Sbjct: 267 PPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPD 326

Query: 544 VQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGN 723
           VQR++ QEIDD+IG+ R   + D+  M YT AVI E  R   +  +G+ HM   D ++  
Sbjct: 327 VQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQG 386

Query: 724 YIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           + IPKGT ++ +L   L     W+ P  F PE FL
Sbjct: 387 FRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 421


>DQ282157-1|ABB77905.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  123 bits (297), Expect = 7e-28
 Identities = 82/275 (29%), Positives = 133/275 (48%), Gaps = 8/275 (2%)
 Frame = +1

Query: 25  YIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           ++ EE   L       +G P   N +    + N++  L  G+R++ +D R  +L  L   
Sbjct: 152 WVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE 211

Query: 205 LFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
             K  + SG    +LN +P L H +P L G  ++     A    L E++ EH+       
Sbjct: 212 GLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQ 266

Query: 376 P-KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNED 543
           P +D+ +AFL +M +++ +               +   AGM T + T  + LL ++ + D
Sbjct: 267 PPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPD 326

Query: 544 VQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGN 723
           VQR++ QEIDD+IG+ R   + D+  M YT AVI E  R   +  +G+ HM   D ++  
Sbjct: 327 VQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQG 386

Query: 724 YIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           + IPKGT ++ +L   L     W+ P  F PE FL
Sbjct: 387 FRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 421


>DQ282156-1|ABB77904.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  123 bits (297), Expect = 7e-28
 Identities = 82/275 (29%), Positives = 133/275 (48%), Gaps = 8/275 (2%)
 Frame = +1

Query: 25  YIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           ++ EE   L       +G P   N +    + N++  L  G+R++ +D R  +L  L   
Sbjct: 152 WVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE 211

Query: 205 LFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
             K  + SG    +LN +P L H +P L G  ++     A    L E++ EH+       
Sbjct: 212 GLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQ 266

Query: 376 P-KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNED 543
           P +D+ +AFL +M +++ +               +   AGM T + T  + LL ++ + D
Sbjct: 267 PPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPD 326

Query: 544 VQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGN 723
           VQR++ QEIDD+IG+ R   + D+  M YT AVI E  R   +  +G+ HM   D ++  
Sbjct: 327 VQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQG 386

Query: 724 YIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           + IPKGT ++ +L   L     W+ P  F PE FL
Sbjct: 387 FRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 421


>DQ282147-1|ABB77898.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  123 bits (297), Expect = 7e-28
 Identities = 82/275 (29%), Positives = 133/275 (48%), Gaps = 8/275 (2%)
 Frame = +1

Query: 25  YIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           ++ EE   L       +G P   N +    + N++  L  G+R++ +D R  +L  L   
Sbjct: 152 WVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE 211

Query: 205 LFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
             K  + SG    +LN +P L H +P L G  ++     A    L E++ EH+       
Sbjct: 212 GLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQ 266

Query: 376 P-KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNED 543
           P +D+ +AFL +M +++ +               +   AGM T + T  + LL ++ + D
Sbjct: 267 PPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPD 326

Query: 544 VQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGN 723
           VQR++ QEIDD+IG+ R   + D+  M YT AVI E  R   +  +G+ HM   D ++  
Sbjct: 327 VQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQG 386

Query: 724 YIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           + IPKGT ++ +L   L     W+ P  F PE FL
Sbjct: 387 FRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 421


>BC126858-1|AAI26859.1|  497|Homo sapiens cytochrome P450, family 2,
           subfamily D, polypeptide 6 protein.
          Length = 497

 Score =  123 bits (297), Expect = 7e-28
 Identities = 82/275 (29%), Positives = 133/275 (48%), Gaps = 8/275 (2%)
 Frame = +1

Query: 25  YIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           ++ EE   L       +G P   N +    + N++  L  G+R++ +D R  +L  L   
Sbjct: 152 WVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE 211

Query: 205 LFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
             K  + SG    +LN +P L H +P L G  ++     A    L E++ EH+       
Sbjct: 212 GLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQ 266

Query: 376 P-KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNED 543
           P +D+ +AFL +M +++ +               +   AGM T + T  + LL ++ + D
Sbjct: 267 PPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPD 326

Query: 544 VQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGN 723
           VQR++ QEIDD+IG+ R   + D+  M YT AVI E  R   +  +G+ HM   D ++  
Sbjct: 327 VQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQG 386

Query: 724 YIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           + IPKGT ++ +L   L     W+ P  F PE FL
Sbjct: 387 FRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 421


>BC067432-1|AAH67432.1|  497|Homo sapiens cytochrome P450, family 2,
           subfamily D, polypeptide 6 protein.
          Length = 497

 Score =  123 bits (297), Expect = 7e-28
 Identities = 82/275 (29%), Positives = 133/275 (48%), Gaps = 8/275 (2%)
 Frame = +1

Query: 25  YIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           ++ EE   L       +G P   N +    + N++  L  G+R++ +D R  +L  L   
Sbjct: 152 WVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE 211

Query: 205 LFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
             K  + SG    +LN +P L H +P L G  ++     A    L E++ EH+       
Sbjct: 212 GLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQ 266

Query: 376 P-KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNED 543
           P +D+ +AFL +M +++ +               +   AGM T + T  + LL ++ + D
Sbjct: 267 PPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPD 326

Query: 544 VQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGN 723
           VQR++ QEIDD+IG+ R   + D+  M YT AVI E  R   +  +G+ HM   D ++  
Sbjct: 327 VQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQG 386

Query: 724 YIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           + IPKGT ++ +L   L     W+ P  F PE FL
Sbjct: 387 FRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 421


>X08006-1|CAA30807.1|  497|Homo sapiens cytochrome P450 db1 protein.
          Length = 497

 Score =  123 bits (296), Expect = 9e-28
 Identities = 82/275 (29%), Positives = 133/275 (48%), Gaps = 8/275 (2%)
 Frame = +1

Query: 25  YIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           ++ EE   L       +G P   N +    + N++  L  G+R++ +D R  +L  L   
Sbjct: 152 WVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE 211

Query: 205 LFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
             K  + SG    +LN +P L H +P L G  ++     A    L E++ EH+       
Sbjct: 212 GLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQ 266

Query: 376 P-KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNED 543
           P +D+ +AFL +M +++ +               +   AGM T + T  + LL ++ + D
Sbjct: 267 PPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPD 326

Query: 544 VQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGN 723
           VQR++ QEIDD+IG+ R   + D+  M YT AVI E  R   +  +G+ HM   D ++  
Sbjct: 327 VQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQG 386

Query: 724 YIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           + IPKGT ++ +L   L     W+ P  F PE FL
Sbjct: 387 FRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 421


>M20403-1|AAA52153.1|  497|Homo sapiens CYP2D protein.
          Length = 497

 Score =  123 bits (296), Expect = 9e-28
 Identities = 82/275 (29%), Positives = 133/275 (48%), Gaps = 8/275 (2%)
 Frame = +1

Query: 25  YIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           ++ EE   L       +G P   N +    + N++  L  G+R++ +D R  +L  L   
Sbjct: 152 WVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE 211

Query: 205 LFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
             K  + SG    +LN +P L H +P L G  ++     A    L E++ EH+       
Sbjct: 212 GLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQ 266

Query: 376 P-KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNED 543
           P +D+ +AFL +M +++ +               +   AGM T + T  + LL ++ + D
Sbjct: 267 PPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPD 326

Query: 544 VQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGN 723
           VQR++ QEIDD+IG+ R   + D+  M YT AVI E  R   +  +G+ HM   D ++  
Sbjct: 327 VQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQG 386

Query: 724 YIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           + IPKGT ++ +L   L     W+ P  F PE FL
Sbjct: 387 FRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 421


>S46963-1|AAB23864.2|  477|Homo sapiens cytochrome P-450 protein.
          Length = 477

 Score =  122 bits (295), Expect = 1e-27
 Identities = 78/272 (28%), Positives = 131/272 (48%), Gaps = 6/272 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           + EE   LV+        P     +      N++  ++  KR+D +DQ+   L   +   
Sbjct: 132 VQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNEN 191

Query: 208 FKLVDMSGGIL--NFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPK 381
            K++      +  NF P + +F        +L +    +  Y+ E +KEHQE++ +  P+
Sbjct: 192 IKILSSPWIQICNNFSPIIDYFPGT---HNKLLKNVAFMKSYILEKVKEHQESMDMNNPQ 248

Query: 382 DVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQR 552
           D ID FL+ M + + ++              +   AG ET + T  + LL ++++ +V  
Sbjct: 249 DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTA 308

Query: 553 KLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYII 732
           K+ +EI+ +IGR+R+  + DR  M YT+AV+ E  R   +    +PH    D K  NY+I
Sbjct: 309 KVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLI 368

Query: 733 PKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           PKGT IL+SL   LH    + +P  F P  FL
Sbjct: 369 PKGTTILISLTSVLHDNKEFPNPEMFDPHHFL 400


>M21940-1|AAA52159.1|  383|Homo sapiens CYP2C protein.
          Length = 383

 Score =  122 bits (295), Expect = 1e-27
 Identities = 78/272 (28%), Positives = 131/272 (48%), Gaps = 6/272 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           + EE   LV+        P     +      N++  ++  KR+D +DQ+   L   +   
Sbjct: 38  VQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNEN 97

Query: 208 FKLVDMSGGIL--NFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPK 381
            K++      +  NF P + +F        +L +    +  Y+ E +KEHQE++ +  P+
Sbjct: 98  IKILSSPWIQICNNFSPIIDYFPGT---HNKLLKNVAFMKSYILEKVKEHQESMDMNNPQ 154

Query: 382 DVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQR 552
           D ID FL+ M + + ++              +   AG ET + T  + LL ++++ +V  
Sbjct: 155 DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTA 214

Query: 553 KLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYII 732
           K+ +EI+ +IGR+R+  + DR  M YT+AV+ E  R   +    +PH    D K  NY+I
Sbjct: 215 KVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRCIDLLPTSLPHAVTCDIKFRNYLI 274

Query: 733 PKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           PKGT IL+SL   LH    + +P  F P  FL
Sbjct: 275 PKGTTILISLTSVLHDNKEFPNPEMFDPHHFL 306


>M21939-1|AAA52158.1|  485|Homo sapiens CYP2C protein.
          Length = 485

 Score =  122 bits (295), Expect = 1e-27
 Identities = 78/272 (28%), Positives = 131/272 (48%), Gaps = 6/272 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           + EE   LV+        P     +      N++  ++  KR+D +DQ+   L   +   
Sbjct: 140 VQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNEN 199

Query: 208 FKLVDMSGGIL--NFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPK 381
            K++      +  NF P + +F        +L +    +  Y+ E +KEHQE++ +  P+
Sbjct: 200 IKILSSPWIQICNNFSPIIDYFPGT---HNKLLKNVAFMKSYILEKVKEHQESMDMNNPQ 256

Query: 382 DVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQR 552
           D ID FL+ M + + ++              +   AG ET + T  + LL ++++ +V  
Sbjct: 257 DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTA 316

Query: 553 KLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYII 732
           K+ +EI+ +IGR+R+  + DR  M YT+AV+ E  R   +    +PH    D K  NY+I
Sbjct: 317 KVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRCIDLLPTSLPHAVTCDIKFRNYLI 376

Query: 733 PKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           PKGT IL+SL   LH    + +P  F P  FL
Sbjct: 377 PKGTTILISLTSVLHDNKEFPNPEMFDPHHFL 408


>M15331-1|AAA52157.1|  485|Homo sapiens CYP2C protein.
          Length = 485

 Score =  122 bits (295), Expect = 1e-27
 Identities = 78/272 (28%), Positives = 131/272 (48%), Gaps = 6/272 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           + EE   LV+        P     +      N++  ++  KR+D +DQ+   L   +   
Sbjct: 140 VQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNEN 199

Query: 208 FKLVDMSGGIL--NFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPK 381
            K++      +  NF P + +F        +L +    +  Y+ E +KEHQE++ +  P+
Sbjct: 200 IKILSSPWIQICNNFSPIIDYFPGT---HNKLLKNVAFMKSYILEKVKEHQESMDMNNPQ 256

Query: 382 DVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQR 552
           D ID FL+ M + + ++              +   AG ET + T  + LL ++++ +V  
Sbjct: 257 DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTA 316

Query: 553 KLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYII 732
           K+ +EI+ +IGR+R+  + DR  M YT+AV+ E  R   +    +PH    D K  NY+I
Sbjct: 317 KVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRCIDLLPTSLPHAVTCDIKFRNYLI 376

Query: 733 PKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           PKGT IL+SL   LH    + +P  F P  FL
Sbjct: 377 PKGTTILISLTSVLHDNKEFPNPEMFDPHHFL 408


>D00173-1|BAA00123.1|  487|Homo sapiens cytochrome P-450 protein.
          Length = 487

 Score =  122 bits (295), Expect = 1e-27
 Identities = 78/272 (28%), Positives = 131/272 (48%), Gaps = 6/272 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           + EE   LV+        P     +      N++  ++  KR+D +DQ+   L   +   
Sbjct: 142 VQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNEN 201

Query: 208 FKLVDMSGGIL--NFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPK 381
            K++      +  NF P + +F        +L +    +  Y+ E +KEHQE++ +  P+
Sbjct: 202 IKILSSPWIQICNNFSPIIDYFPGT---HNKLLKNVAFMKSYILEKVKEHQESMDMNNPQ 258

Query: 382 DVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQR 552
           D ID FL+ M + + ++              +   AG ET + T  + LL ++++ +V  
Sbjct: 259 DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTA 318

Query: 553 KLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYII 732
           K+ +EI+ +IGR+R+  + DR  M YT+AV+ E  R   +    +PH    D K  NY+I
Sbjct: 319 KVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLI 378

Query: 733 PKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           PKGT IL+SL   LH    + +P  F P  FL
Sbjct: 379 PKGTTILISLTSVLHDNKEFPNPEMFDPHHFL 410


>DQ282153-1|ABB77901.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  122 bits (295), Expect = 1e-27
 Identities = 82/275 (29%), Positives = 133/275 (48%), Gaps = 8/275 (2%)
 Frame = +1

Query: 25  YIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           ++ EE   L       +G P   N +    + N++  L  G+R++ +D R  +L  L   
Sbjct: 152 WVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE 211

Query: 205 LFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
             K  + SG    +LN +P L H +P L G  ++     A    L E++ EH+       
Sbjct: 212 GLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQ 266

Query: 376 P-KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNED 543
           P +D+ +AFL +M +++ +               +   AGM T + T  + LL ++ + D
Sbjct: 267 PPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPD 326

Query: 544 VQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGN 723
           VQR++ QEIDD+IG+ R   + D+  M YT AVI E  R   +  +G+ HM   D ++  
Sbjct: 327 VQRRVQQEIDDMIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQG 386

Query: 724 YIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           + IPKGT ++ +L   L     W+ P  F PE FL
Sbjct: 387 FRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 421


>DQ282151-1|ABB77899.1|  496|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 496

 Score =  122 bits (295), Expect = 1e-27
 Identities = 82/274 (29%), Positives = 130/274 (47%), Gaps = 7/274 (2%)
 Frame = +1

Query: 25  YIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           ++ EE   L       +G P   N +    + N++  L  G+R++ +D R  +L  L   
Sbjct: 152 WVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE 211

Query: 205 LFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
             K  + SG    +LN +P L H +P L G  ++     A    L E++ EH+       
Sbjct: 212 GLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQ 266

Query: 376 P-KDVIDAFLIDMLE--SQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVRNEDV 546
           P +D+ +AFL +M    + +                 AGM T + T  + LL ++ + DV
Sbjct: 267 PPRDLTEAFLAEMEAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDV 326

Query: 547 QRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNY 726
           QR++ QEIDD+IG+ R   + D+  M YT AVI E  R   +  +G+ HM   D ++  +
Sbjct: 327 QRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGF 386

Query: 727 IIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
            IPKGT ++ +L   L     W+ P  F PE FL
Sbjct: 387 RIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 420


>BC125054-1|AAI25055.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 9 protein.
          Length = 490

 Score =  122 bits (295), Expect = 1e-27
 Identities = 78/272 (28%), Positives = 131/272 (48%), Gaps = 6/272 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           + EE   LV+        P     +      N++  ++  KR+D +DQ+   L   +   
Sbjct: 145 VQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNEN 204

Query: 208 FKLVDMSGGIL--NFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPK 381
            K++      +  NF P + +F        +L +    +  Y+ E +KEHQE++ +  P+
Sbjct: 205 IKILSSPWIQICNNFSPIIDYFPGT---HNKLLKNVAFMKSYILEKVKEHQESMDMNNPQ 261

Query: 382 DVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQR 552
           D ID FL+ M + + ++              +   AG ET + T  + LL ++++ +V  
Sbjct: 262 DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTA 321

Query: 553 KLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYII 732
           K+ +EI+ +IGR+R+  + DR  M YT+AV+ E  R   +    +PH    D K  NY+I
Sbjct: 322 KVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLI 381

Query: 733 PKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           PKGT IL+SL   LH    + +P  F P  FL
Sbjct: 382 PKGTTILISLTSVLHDNKEFPNPEMFDPHHFL 413


>AY702706-1|AAT94065.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 9 protein.
          Length = 490

 Score =  122 bits (295), Expect = 1e-27
 Identities = 78/272 (28%), Positives = 131/272 (48%), Gaps = 6/272 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           + EE   LV+        P     +      N++  ++  KR+D +DQ+   L   +   
Sbjct: 145 VQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNEN 204

Query: 208 FKLVDMSGGIL--NFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPK 381
            K++      +  NF P + +F        +L +    +  Y+ E +KEHQE++ +  P+
Sbjct: 205 IKILSSPWIQICNNFSPIIDYFPGT---HNKLLKNVAFMKSYILEKVKEHQESMDMNNPQ 261

Query: 382 DVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQR 552
           D ID FL+ M + + ++              +   AG ET + T  + LL ++++ +V  
Sbjct: 262 DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTA 321

Query: 553 KLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYII 732
           K+ +EI+ +IGR+R+  + DR  M YT+AV+ E  R   +    +PH    D K  NY+I
Sbjct: 322 KVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLI 381

Query: 733 PKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           PKGT IL+SL   LH    + +P  F P  FL
Sbjct: 382 PKGTTILISLTSVLHDNKEFPNPEMFDPHHFL 413


>AY513609-1|AAR90940.1|  494|Homo sapiens cytochrome P450 2A13
           variant 6 protein.
          Length = 494

 Score =  122 bits (295), Expect = 1e-27
 Identities = 80/273 (29%), Positives = 131/273 (47%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE   L+       G  I        T+ N++  +V G R+D ED+    L  +++  
Sbjct: 149 IQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGS 208

Query: 208 FKLVDMSGGILN--FLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAP 378
           F+    S G L   F   ++H   P+   F ELQ     L  ++ + ++ +Q  L   +P
Sbjct: 209 FQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQ----GLEDFIAKKVEHNQRTLDPNSP 264

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D ID+FLI M E + +                   AG ETV+ T  +  L ++++ +++
Sbjct: 265 RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPELE 324

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            K+H+EID +IG++R    +DR +M YTEAVI E  R   +  MG+ H    D K  ++ 
Sbjct: 325 AKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFF 384

Query: 730 IPKGTFILLSLYXLHHGPH-WKDPXTFRPERFL 825
           +PKGT +   L  +   P  + +P  F P+ FL
Sbjct: 385 LPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFL 417


>AY341248-1|AAP88931.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 9 protein.
          Length = 490

 Score =  122 bits (295), Expect = 1e-27
 Identities = 78/272 (28%), Positives = 131/272 (48%), Gaps = 6/272 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           + EE   LV+        P     +      N++  ++  KR+D +DQ+   L   +   
Sbjct: 145 VQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNEN 204

Query: 208 FKLVDMSGGIL--NFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPK 381
            K++      +  NF P + +F        +L +    +  Y+ E +KEHQE++ +  P+
Sbjct: 205 IKILSSPWIQICNNFSPIIDYFPGT---HNKLLKNVAFMKSYILEKVKEHQESMDMNNPQ 261

Query: 382 DVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQR 552
           D ID FL+ M + + ++              +   AG ET + T  + LL ++++ +V  
Sbjct: 262 DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTA 321

Query: 553 KLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYII 732
           K+ +EI+ +IGR+R+  + DR  M YT+AV+ E  R   +    +PH    D K  NY+I
Sbjct: 322 KVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLI 381

Query: 733 PKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           PKGT IL+SL   LH    + +P  F P  FL
Sbjct: 382 PKGTTILISLTSVLHDNKEFPNPEMFDPHHFL 413


>AL359672-1|CAH71303.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 9 protein.
          Length = 490

 Score =  122 bits (295), Expect = 1e-27
 Identities = 78/272 (28%), Positives = 131/272 (48%), Gaps = 6/272 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           + EE   LV+        P     +      N++  ++  KR+D +DQ+   L   +   
Sbjct: 145 VQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNEN 204

Query: 208 FKLVDMSGGIL--NFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPK 381
            K++      +  NF P + +F        +L +    +  Y+ E +KEHQE++ +  P+
Sbjct: 205 IKILSSPWIQICNNFSPIIDYFPGT---HNKLLKNVAFMKSYILEKVKEHQESMDMNNPQ 261

Query: 382 DVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQR 552
           D ID FL+ M + + ++              +   AG ET + T  + LL ++++ +V  
Sbjct: 262 DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTA 321

Query: 553 KLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYII 732
           K+ +EI+ +IGR+R+  + DR  M YT+AV+ E  R   +    +PH    D K  NY+I
Sbjct: 322 KVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLI 381

Query: 733 PKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           PKGT IL+SL   LH    + +P  F P  FL
Sbjct: 382 PKGTTILISLTSVLHDNKEFPNPEMFDPHHFL 413


>DQ282155-1|ABB77903.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  122 bits (293), Expect = 2e-27
 Identities = 81/275 (29%), Positives = 133/275 (48%), Gaps = 8/275 (2%)
 Frame = +1

Query: 25  YIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           ++ +E   L       +G P   N +    + N++  L  G+R++ +D R  +L  L   
Sbjct: 152 WVTKEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE 211

Query: 205 LFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
             K  + SG    +LN +P L H +P L G  ++     A    L E++ EH+       
Sbjct: 212 GLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQ 266

Query: 376 P-KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNED 543
           P +D+ +AFL +M +++ +               +   AGM T + T  + LL ++ + D
Sbjct: 267 PPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPD 326

Query: 544 VQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGN 723
           VQR++ QEIDD+IG+ R   + D+  M YT AVI E  R   +  +G+ HM   D ++  
Sbjct: 327 VQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQG 386

Query: 724 YIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           + IPKGT ++ +L   L     W+ P  F PE FL
Sbjct: 387 FRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 421


>BC106758-1|AAI06759.1|  497|Homo sapiens cytochrome P450, family 2,
           subfamily D, polypeptide 6 protein.
          Length = 497

 Score =  122 bits (293), Expect = 2e-27
 Identities = 81/275 (29%), Positives = 133/275 (48%), Gaps = 8/275 (2%)
 Frame = +1

Query: 25  YIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           ++ EE   L       +G P   N +    + N++  L  G+R++ +D R  +L  L   
Sbjct: 152 WVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE 211

Query: 205 LFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
             K  + SG    +LN +P L H +P L G  ++     A    L E++ EH+       
Sbjct: 212 GLK--EESGFLREVLNAVPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQ 266

Query: 376 P-KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNED 543
           P +D+ +AFL +M +++ +               +   AGM T + T  + LL ++ + D
Sbjct: 267 PPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPD 326

Query: 544 VQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGN 723
           VQR++ QEID++IG+ R   + D+  M YT AVI E  R   +  +G+ HM   D ++  
Sbjct: 327 VQRRVQQEIDEVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQG 386

Query: 724 YIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           + IPKGT ++ +L   L     W+ P  F PE FL
Sbjct: 387 FRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 421


>M61854-1|AAB59426.1|  490|Homo sapiens cytochrome protein.
          Length = 490

 Score =  121 bits (291), Expect = 4e-27
 Identities = 79/271 (29%), Positives = 127/271 (46%), Gaps = 5/271 (1%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           + EE   LV+        P     +      N++  ++  KR+D +DQ+   L   +   
Sbjct: 145 VQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNEN 204

Query: 208 FKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKD 384
            ++V      I N  P +  + P      +L +    +   + E +KEHQE++ +  P+D
Sbjct: 205 IRIVSTPWIQICNNFPTIIDYFPGT--HNKLLKNLAFMESDILEKVKEHQESMDINNPRD 262

Query: 385 VIDAFLIDM---LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVRNEDVQRK 555
            ID FLI M    ++Q  +               AG ET + T  + LL ++++ +V  K
Sbjct: 263 FIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAK 322

Query: 556 LHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIP 735
           + +EI+ +IGR+R+  + DR  M YT+AV+ E  R   +    +PH    D K  NY+IP
Sbjct: 323 VQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIP 382

Query: 736 KGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           KGT IL SL   LH    + +P  F P  FL
Sbjct: 383 KGTTILTSLTSVLHDNKEFPNPEMFDPRHFL 413


>EF122241-1|ABO41976.1|  491|Homo sapiens cytochrome P450 2F1
           variant protein.
          Length = 491

 Score =  121 bits (291), Expect = 4e-27
 Identities = 77/264 (29%), Positives = 125/264 (47%), Gaps = 5/264 (1%)
 Frame = +1

Query: 49  LVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMS 228
           L +LR  + GEP     +   ++ NI+  ++ G R+D +D+RL  +  L+   F+++   
Sbjct: 154 LAELRKTE-GEPFDPTFVLSRSVSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSP 212

Query: 229 GGIL-NFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKDVIDAFLI 405
            G L N  P L  +VP       + +    L   +   + +HQ +L   +P+D I  FL 
Sbjct: 213 WGELYNIFPSLLDWVPG--PHQRIFQNFKCLRDLIAHSVHDHQASLDPRSPRDFIHCFLT 270

Query: 406 DMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDD 576
            M E ++D                    G +TV+ T     L +++   VQ ++ +EID 
Sbjct: 271 KMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTVSTTLHHAFLALMKYPKVQARVQEEIDL 330

Query: 577 IIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILL 756
           ++GR R   L DR  M YT+AVI E  R + +  M +PH    D     ++IPKGT ++ 
Sbjct: 331 VVGRARLPALKDRAAMPYTDAVIHEVQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVIT 390

Query: 757 SLYXLHHGP-HWKDPXTFRPERFL 825
            L  +H+ P  +  P  F PE FL
Sbjct: 391 LLNTVHYDPSQFLTPQEFNPEHFL 414


>L07093-1|AAA36660.1|  468|Homo sapiens cytochrome P450 protein.
          Length = 468

 Score =  120 bits (290), Expect = 5e-27
 Identities = 78/271 (28%), Positives = 127/271 (46%), Gaps = 5/271 (1%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           + EE   LV+        P     +      N++  ++  KR+D +DQ+   L   +   
Sbjct: 123 VQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNEN 182

Query: 208 FKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKD 384
            ++V      I N  P +  + P      +L +    +   + E +KEHQE++ +  P+D
Sbjct: 183 IRIVSTPWIQICNNFPTIIDYFPGT--HNKLLKNLAFMESDILEKVKEHQESMDINNPRD 240

Query: 385 VIDAFLIDM---LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVRNEDVQRK 555
            ID FLI M    ++Q  +               AG ET + T  + LL ++++ +V  K
Sbjct: 241 FIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAK 300

Query: 556 LHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIP 735
           + +EI+ ++GR+R+  + DR  M YT+AV+ E  R   +    +PH    D K  NY+IP
Sbjct: 301 VQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIP 360

Query: 736 KGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           KGT IL SL   LH    + +P  F P  FL
Sbjct: 361 KGTTILTSLTSVLHDNKEFPNPEMFDPRHFL 391


>CR456430-1|CAG30316.1|  446|Homo sapiens CYP2D6 protein.
          Length = 446

 Score =  120 bits (290), Expect = 5e-27
 Identities = 79/258 (30%), Positives = 127/258 (49%), Gaps = 8/258 (3%)
 Frame = +1

Query: 76  GEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSG---GILNF 246
           G P   N +    + N++  L  G+R++ +D R  +L  L     K  + SG    +LN 
Sbjct: 118 GRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLK--EESGFLREVLNA 175

Query: 247 LPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAP-KDVIDAFLIDMLESQ 423
           +P L H +P L G  ++     A    L E++ EH+       P +D+ +AFL +M +++
Sbjct: 176 VPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAK 232

Query: 424 DDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDR 594
            +               +   AGM T + T  + LL ++ + DVQR++ QEIDD+IG+ R
Sbjct: 233 GNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVR 292

Query: 595 NHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYX-L 771
              + D+  M YT AVI E  R   +  +G+ HM   D ++  + IPKGT ++ +L   L
Sbjct: 293 RPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVL 352

Query: 772 HHGPHWKDPXTFRPERFL 825
                W+ P  F PE FL
Sbjct: 353 KDEAVWEKPFRFHPEHFL 370


>BC106757-1|AAI06758.1|  446|Homo sapiens cytochrome P450, family 2,
           subfamily D, polypeptide 6 protein.
          Length = 446

 Score =  120 bits (290), Expect = 5e-27
 Identities = 79/258 (30%), Positives = 127/258 (49%), Gaps = 8/258 (3%)
 Frame = +1

Query: 76  GEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSG---GILNF 246
           G P   N +    + N++  L  G+R++ +D R  +L  L     K  + SG    +LN 
Sbjct: 118 GRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLK--EESGFLREVLNA 175

Query: 247 LPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAP-KDVIDAFLIDMLESQ 423
           +P L H +P L G  ++     A    L E++ EH+       P +D+ +AFL +M +++
Sbjct: 176 VPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAK 232

Query: 424 DDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDR 594
            +               +   AGM T + T  + LL ++ + DVQR++ QEIDD+IG+ R
Sbjct: 233 GNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVR 292

Query: 595 NHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYX-L 771
              + D+  M YT AVI E  R   +  +G+ HM   D ++  + IPKGT ++ +L   L
Sbjct: 293 RPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVL 352

Query: 772 HHGPHWKDPXTFRPERFL 825
                W+ P  F PE FL
Sbjct: 353 KDEAVWEKPFRFHPEHFL 370


>BC066877-1|AAH66877.1|  446|Homo sapiens CYP2D6 protein protein.
          Length = 446

 Score =  120 bits (290), Expect = 5e-27
 Identities = 79/258 (30%), Positives = 127/258 (49%), Gaps = 8/258 (3%)
 Frame = +1

Query: 76  GEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSG---GILNF 246
           G P   N +    + N++  L  G+R++ +D R  +L  L     K  + SG    +LN 
Sbjct: 118 GRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLK--EESGFLREVLNA 175

Query: 247 LPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAP-KDVIDAFLIDMLESQ 423
           +P L H +P L G  ++     A    L E++ EH+       P +D+ +AFL +M +++
Sbjct: 176 VPVLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAK 232

Query: 424 DDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDR 594
            +               +   AGM T + T  + LL ++ + DVQR++ QEIDD+IG+ R
Sbjct: 233 GNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVR 292

Query: 595 NHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYX-L 771
              + D+  M YT AVI E  R   +  +G+ HM   D ++  + IPKGT ++ +L   L
Sbjct: 293 RPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVL 352

Query: 772 HHGPHWKDPXTFRPERFL 825
                W+ P  F PE FL
Sbjct: 353 KDEAVWEKPFRFHPEHFL 370


>AY796203-1|AAV41877.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 19 protein.
          Length = 490

 Score =  120 bits (290), Expect = 5e-27
 Identities = 78/271 (28%), Positives = 127/271 (46%), Gaps = 5/271 (1%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           + EE   LV+        P     +      N++  ++  KR+D +DQ+   L   +   
Sbjct: 145 VQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNEN 204

Query: 208 FKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKD 384
            ++V      I N  P +  + P      +L +    +   + E +KEHQE++ +  P+D
Sbjct: 205 IRIVSTPWIQICNNFPTIIDYFPGT--HNKLLKNLAFMESDILEKVKEHQESMDINNPRD 262

Query: 385 VIDAFLIDM---LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVRNEDVQRK 555
            ID FLI M    ++Q  +               AG ET + T  + LL ++++ +V  K
Sbjct: 263 FIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAK 322

Query: 556 LHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIP 735
           + +EI+ ++GR+R+  + DR  M YT+AV+ E  R   +    +PH    D K  NY+IP
Sbjct: 323 VQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIP 382

Query: 736 KGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           KGT IL SL   LH    + +P  F P  FL
Sbjct: 383 KGTTILTSLTSVLHDNKEFPNPEMFDPRHFL 413


>AL583836-2|CAH74068.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 19 protein.
          Length = 490

 Score =  120 bits (290), Expect = 5e-27
 Identities = 78/271 (28%), Positives = 127/271 (46%), Gaps = 5/271 (1%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           + EE   LV+        P     +      N++  ++  KR+D +DQ+   L   +   
Sbjct: 145 VQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNEN 204

Query: 208 FKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKD 384
            ++V      I N  P +  + P      +L +    +   + E +KEHQE++ +  P+D
Sbjct: 205 IRIVSTPWIQICNNFPTIIDYFPGT--HNKLLKNLAFMESDILEKVKEHQESMDINNPRD 262

Query: 385 VIDAFLIDM---LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVRNEDVQRK 555
            ID FLI M    ++Q  +               AG ET + T  + LL ++++ +V  K
Sbjct: 263 FIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAK 322

Query: 556 LHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIP 735
           + +EI+ ++GR+R+  + DR  M YT+AV+ E  R   +    +PH    D K  NY+IP
Sbjct: 323 VQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIP 382

Query: 736 KGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           KGT IL SL   LH    + +P  F P  FL
Sbjct: 383 KGTTILTSLTSVLHDNKEFPNPEMFDPRHFL 413


>AL133513-2|CAH73444.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 19 protein.
          Length = 490

 Score =  120 bits (290), Expect = 5e-27
 Identities = 78/271 (28%), Positives = 127/271 (46%), Gaps = 5/271 (1%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           + EE   LV+        P     +      N++  ++  KR+D +DQ+   L   +   
Sbjct: 145 VQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNEN 204

Query: 208 FKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKD 384
            ++V      I N  P +  + P      +L +    +   + E +KEHQE++ +  P+D
Sbjct: 205 IRIVSTPWIQICNNFPTIIDYFPGT--HNKLLKNLAFMESDILEKVKEHQESMDINNPRD 262

Query: 385 VIDAFLIDM---LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVRNEDVQRK 555
            ID FLI M    ++Q  +               AG ET + T  + LL ++++ +V  K
Sbjct: 263 FIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAK 322

Query: 556 LHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIP 735
           + +EI+ ++GR+R+  + DR  M YT+AV+ E  R   +    +PH    D K  NY+IP
Sbjct: 323 VQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIP 382

Query: 736 KGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           KGT IL SL   LH    + +P  F P  FL
Sbjct: 383 KGTTILTSLTSVLHDNKEFPNPEMFDPRHFL 413


>M61856-1|AAB59356.1|  490|Homo sapiens cytochrome protein.
          Length = 490

 Score =  120 bits (289), Expect = 6e-27
 Identities = 80/272 (29%), Positives = 132/272 (48%), Gaps = 6/272 (2%)
 Frame = +1

Query: 28  IGEECEALVQ-LRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           + EE   LV+ LR  +A  P     +      N++  ++   R+D +DQR   L      
Sbjct: 145 VQEEARCLVEELRKTNAS-PCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNE 203

Query: 205 LFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPK 381
             +++      + N  P L  ++P      ++ E    +  Y+ E IKEHQE+L + + +
Sbjct: 204 NLRILSSPWIQVCNNFPALIDYLPG--SHNKIAENFAYIKSYVLERIKEHQESLDMNSAR 261

Query: 382 DVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQR 552
           D ID FLI M + + ++              +   AG ET + T  + LL +++  +V  
Sbjct: 262 DFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTA 321

Query: 553 KLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYII 732
           K+ +EI+ ++GR+R+  + DR  M YT+AV+ E  R   +    +PH    D K  NY+I
Sbjct: 322 KVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLI 381

Query: 733 PKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           PKGT I+ SL   LH+   + +P  F P  FL
Sbjct: 382 PKGTTIITSLTSVLHNDKEFPNPEMFDPGHFL 413


>BC096259-1|AAH96259.1|  443|Homo sapiens CYP2C18 protein protein.
          Length = 443

 Score =  120 bits (289), Expect = 6e-27
 Identities = 80/272 (29%), Positives = 132/272 (48%), Gaps = 6/272 (2%)
 Frame = +1

Query: 28  IGEECEALVQ-LRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           + EE   LV+ LR  +A  P     +      N++  ++   R+D +DQR   L      
Sbjct: 145 VQEEARCLVEELRKTNAS-PCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNE 203

Query: 205 LFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPK 381
             +++      + N  P L  ++P      ++ E    +  Y+ E IKEHQE+L + + +
Sbjct: 204 NLRILSSPWIQVCNNFPALIDYLPG--SHNKIAENFAYIKSYVLERIKEHQESLDMNSAR 261

Query: 382 DVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQR 552
           D ID FLI M + + ++              +   AG ET + T  + LL +++  +V  
Sbjct: 262 DFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTA 321

Query: 553 KLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYII 732
           K+ +EI+ ++GR+R+  + DR  M YT+AV+ E  R   +    +PH    D K  NY+I
Sbjct: 322 KVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLI 381

Query: 733 PKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           PKGT I+ SL   LH+   + +P  F P  FL
Sbjct: 382 PKGTTIITSLTSVLHNDKEFPNPEMFDPGHFL 413


>BC096258-1|AAH96258.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 18 protein.
          Length = 490

 Score =  120 bits (289), Expect = 6e-27
 Identities = 80/272 (29%), Positives = 132/272 (48%), Gaps = 6/272 (2%)
 Frame = +1

Query: 28  IGEECEALVQ-LRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           + EE   LV+ LR  +A  P     +      N++  ++   R+D +DQR   L      
Sbjct: 145 VQEEARCLVEELRKTNAS-PCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNE 203

Query: 205 LFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPK 381
             +++      + N  P L  ++P      ++ E    +  Y+ E IKEHQE+L + + +
Sbjct: 204 NLRILSSPWIQVCNNFPALIDYLPG--SHNKIAENFAYIKSYVLERIKEHQESLDMNSAR 261

Query: 382 DVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQR 552
           D ID FLI M + + ++              +   AG ET + T  + LL +++  +V  
Sbjct: 262 DFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTA 321

Query: 553 KLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYII 732
           K+ +EI+ ++GR+R+  + DR  M YT+AV+ E  R   +    +PH    D K  NY+I
Sbjct: 322 KVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLI 381

Query: 733 PKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           PKGT I+ SL   LH+   + +P  F P  FL
Sbjct: 382 PKGTTIITSLTSVLHNDKEFPNPEMFDPGHFL 413


>BC096257-1|AAH96257.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 18 protein.
          Length = 490

 Score =  120 bits (289), Expect = 6e-27
 Identities = 80/272 (29%), Positives = 132/272 (48%), Gaps = 6/272 (2%)
 Frame = +1

Query: 28  IGEECEALVQ-LRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           + EE   LV+ LR  +A  P     +      N++  ++   R+D +DQR   L      
Sbjct: 145 VQEEARCLVEELRKTNAS-PCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNE 203

Query: 205 LFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPK 381
             +++      + N  P L  ++P      ++ E    +  Y+ E IKEHQE+L + + +
Sbjct: 204 NLRILSSPWIQVCNNFPALIDYLPG--SHNKIAENFAYIKSYVLERIKEHQESLDMNSAR 261

Query: 382 DVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQR 552
           D ID FLI M + + ++              +   AG ET + T  + LL +++  +V  
Sbjct: 262 DFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTA 321

Query: 553 KLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYII 732
           K+ +EI+ ++GR+R+  + DR  M YT+AV+ E  R   +    +PH    D K  NY+I
Sbjct: 322 KVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLI 381

Query: 733 PKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           PKGT I+ SL   LH+   + +P  F P  FL
Sbjct: 382 PKGTTIITSLTSVLHNDKEFPNPEMFDPGHFL 413


>BC069666-1|AAH69666.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 18 protein.
          Length = 490

 Score =  120 bits (289), Expect = 6e-27
 Identities = 80/272 (29%), Positives = 132/272 (48%), Gaps = 6/272 (2%)
 Frame = +1

Query: 28  IGEECEALVQ-LRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           + EE   LV+ LR  +A  P     +      N++  ++   R+D +DQR   L      
Sbjct: 145 VQEEARCLVEELRKTNAS-PCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNE 203

Query: 205 LFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPK 381
             +++      + N  P L  ++P      ++ E    +  Y+ E IKEHQE+L + + +
Sbjct: 204 NLRILSSPWIQVCNNFPALIDYLPG--SHNKIAENFAYIKSYVLERIKEHQESLDMNSAR 261

Query: 382 DVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQR 552
           D ID FLI M + + ++              +   AG ET + T  + LL +++  +V  
Sbjct: 262 DFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTA 321

Query: 553 KLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYII 732
           K+ +EI+ ++GR+R+  + DR  M YT+AV+ E  R   +    +PH    D K  NY+I
Sbjct: 322 KVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLI 381

Query: 733 PKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           PKGT I+ SL   LH+   + +P  F P  FL
Sbjct: 382 PKGTTIITSLTSVLHNDKEFPNPEMFDPGHFL 413


>AL583836-1|CAH74067.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 18 protein.
          Length = 490

 Score =  120 bits (289), Expect = 6e-27
 Identities = 80/272 (29%), Positives = 132/272 (48%), Gaps = 6/272 (2%)
 Frame = +1

Query: 28  IGEECEALVQ-LRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           + EE   LV+ LR  +A  P     +      N++  ++   R+D +DQR   L      
Sbjct: 145 VQEEARCLVEELRKTNAS-PCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNE 203

Query: 205 LFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPK 381
             +++      + N  P L  ++P      ++ E    +  Y+ E IKEHQE+L + + +
Sbjct: 204 NLRILSSPWIQVCNNFPALIDYLPG--SHNKIAENFAYIKSYVLERIKEHQESLDMNSAR 261

Query: 382 DVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQR 552
           D ID FLI M + + ++              +   AG ET + T  + LL +++  +V  
Sbjct: 262 DFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTA 321

Query: 553 KLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYII 732
           K+ +EI+ ++GR+R+  + DR  M YT+AV+ E  R   +    +PH    D K  NY+I
Sbjct: 322 KVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLI 381

Query: 733 PKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           PKGT I+ SL   LH+   + +P  F P  FL
Sbjct: 382 PKGTTIITSLTSVLHNDKEFPNPEMFDPGHFL 413


>AK223510-1|BAD97230.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 18 variant protein.
          Length = 490

 Score =  120 bits (289), Expect = 6e-27
 Identities = 80/272 (29%), Positives = 132/272 (48%), Gaps = 6/272 (2%)
 Frame = +1

Query: 28  IGEECEALVQ-LRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           + EE   LV+ LR  +A  P     +      N++  ++   R+D +DQR   L      
Sbjct: 145 VQEEARCLVEELRKTNAS-PCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNE 203

Query: 205 LFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPK 381
             +++      + N  P L  ++P      ++ E    +  Y+ E IKEHQE+L + + +
Sbjct: 204 NLRILSSPWIQVCNNFPALIDYLPG--SHNKIAENFAYIKSYVLERIKEHQESLDMNSAR 261

Query: 382 DVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQR 552
           D ID FLI M + + ++              +   AG ET + T  + LL +++  +V  
Sbjct: 262 DFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTA 321

Query: 553 KLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYII 732
           K+ +EI+ ++GR+R+  + DR  M YT+AV+ E  R   +    +PH    D K  NY+I
Sbjct: 322 KVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLI 381

Query: 733 PKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           PKGT I+ SL   LH+   + +P  F P  FL
Sbjct: 382 PKGTTIITSLTSVLHNDKEFPNPEMFDPGHFL 413


>U22028-1|AAB40519.1|  494|Homo sapiens cytochrome P450 protein.
          Length = 494

 Score =  119 bits (286), Expect = 1e-26
 Identities = 80/273 (29%), Positives = 129/273 (47%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE   L+       G  I        T+ N++  +V G R+D ED+    L  +++  
Sbjct: 149 IQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGR 208

Query: 208 FKLVDMSGGILN--FLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAP 378
           F+    S G L   F   ++H   P+   F ELQ     L  ++ + ++ +Q  L   +P
Sbjct: 209 FQFTGTSTGQLYEMFSSVMKHLPGPQQQAFKELQ----GLEDFIAKKVEHNQRTLDPNSP 264

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D ID+FLI M E + +                   AG ETV+ T  +  L ++++ +V+
Sbjct: 265 RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVE 324

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            K+H+EID +IG++R    +DR +M YTEAVI E  R   +  MG+ H    D K  ++ 
Sbjct: 325 AKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFF 384

Query: 730 IPKGTFILLSLYXLHHGPH-WKDPXTFRPERFL 825
           +PKGT +   L      P  + +P    P+ FL
Sbjct: 385 LPKGTEVFPMLGSELRDPRFFSNPQDCSPQHFL 417


>M33317-1|AAA52138.1|  494|Homo sapiens CYP2A protein.
          Length = 494

 Score =  119 bits (286), Expect = 1e-26
 Identities = 79/273 (28%), Positives = 131/273 (47%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE   L++   +  G  I        T+ N++  +V G R+D ED+    L S+++ +
Sbjct: 149 IQEESGFLIEAIRSSHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGI 208

Query: 208 FKLVDMSGGILN--FLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAP 378
           F+    S G L   F   ++H   P+   F  LQ     L  ++ + ++ +Q  L   +P
Sbjct: 209 FQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQ----GLEDFIAKKVEHNQRTLDPNSP 264

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D ID+FLI M E + +                   AG ETV+ T  +  L ++++ +V+
Sbjct: 265 QDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVE 324

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            K+H+EID +IG++R    +DR +M Y EAVI E  R   V  M +      D K  ++ 
Sbjct: 325 AKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFF 384

Query: 730 IPKGTFILLSLYXLHHGP-HWKDPXTFRPERFL 825
           +PKGT +   L  +   P  + +P  F P+ FL
Sbjct: 385 LPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFL 417


>M33189-1|AAA35737.1|  500|Homo sapiens protein ( Human debrisoquine
           4-hydroxylase mutant allele (CYP2D6-MA1) gene, complete
           cds. ).
          Length = 500

 Score =  118 bits (285), Expect = 2e-26
 Identities = 78/256 (30%), Positives = 126/256 (49%), Gaps = 8/256 (3%)
 Frame = +1

Query: 82  PILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSG---GILNFLP 252
           P   N +    + N++  L  G+R++ +D R  +L  L     K  + SG    +LN +P
Sbjct: 174 PFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLK--EESGFLREVLNAVP 231

Query: 253 FLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAP-KDVIDAFLIDMLESQDD 429
            L H +P L G  ++     A    L E++ EH+       P +D+ +AFL +M +++ +
Sbjct: 232 VLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGN 288

Query: 430 KXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNH 600
                          +   AGM T + T  + LL ++ + DVQR++ QEIDD+IG+ R  
Sbjct: 289 PESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP 348

Query: 601 LLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYX-LHH 777
            + D+  M YT AVI E  R   +  +G+ HM   D ++  + IPKGT ++ +L   L  
Sbjct: 349 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 408

Query: 778 GPHWKDPXTFRPERFL 825
              W+ P  F PE FL
Sbjct: 409 EAVWEKPFRFHPEHFL 424


>Z00036-1|CAA77335.1|  515|Homo sapiens protein ( Human mRNA for
           cytochrome P-3-450. ).
          Length = 515

 Score =  118 bits (284), Expect = 3e-26
 Identities = 78/282 (27%), Positives = 139/282 (49%), Gaps = 10/282 (3%)
 Frame = +1

Query: 13  FMNVYIGEECEALV---QLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKK 183
           ++  ++ +E +AL+   Q  +A  G     NQ+  +++ N++  +  G+ +    +   +
Sbjct: 160 YLEEHVSKEAKALISRLQELMAGPGHFDPYNQVV-VSVANVIGAMCFGQHFP---ESSDE 215

Query: 184 LCSLVMRLFKLVDM--SGGILNFLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQ 354
           + SLV    + V+   SG  L+F P LR+   P L  F   +  +     +L++ ++EH 
Sbjct: 216 MLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRF---KAFNQRFLWFLQKTVQEHY 272

Query: 355 ENLQLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLH 525
           ++    + +D+  A      +                   +   AG +TVT    + L++
Sbjct: 273 QDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMY 332

Query: 526 VVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           +V   ++QRK+ +E+D +IGR+R   L DR ++ Y EA ILET R S+     IPH    
Sbjct: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR 392

Query: 706 DAKLGNYIIPKGTFILLSLYXLHHGPH-WKDPXTFRPERFLT 828
           D  L  + IPK   + ++ + ++H P  W+DP  FRPERFLT
Sbjct: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434


>M55053-1|AAA52146.1|  515|Homo sapiens cytochrome P3-450 protein.
          Length = 515

 Score =  118 bits (284), Expect = 3e-26
 Identities = 78/282 (27%), Positives = 139/282 (49%), Gaps = 10/282 (3%)
 Frame = +1

Query: 13  FMNVYIGEECEALV---QLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKK 183
           ++  ++ +E +AL+   Q  +A  G     NQ+  +++ N++  +  G+ +    +   +
Sbjct: 160 YLEEHVSKEAKALISRLQELMAGPGHFDPYNQVV-VSVANVIGAMCFGQHFP---ESSDE 215

Query: 184 LCSLVMRLFKLVDM--SGGILNFLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQ 354
           + SLV    + V+   SG  L+F P LR+   P L  F   +  +     +L++ ++EH 
Sbjct: 216 MLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRF---KAFNQRFLWFLQKTVQEHY 272

Query: 355 ENLQLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLH 525
           ++    + +D+  A      +                   +   AG +TVT    + L++
Sbjct: 273 QDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMY 332

Query: 526 VVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           +V   ++QRK+ +E+D +IGR+R   L DR ++ Y EA ILET R S+     IPH    
Sbjct: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR 392

Query: 706 DAKLGNYIIPKGTFILLSLYXLHHGPH-WKDPXTFRPERFLT 828
           D  L  + IPK   + ++ + ++H P  W+DP  FRPERFLT
Sbjct: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434


>M31667-1|AAA52163.1|  515|Homo sapiens CYP1A2 protein.
          Length = 515

 Score =  118 bits (284), Expect = 3e-26
 Identities = 78/282 (27%), Positives = 139/282 (49%), Gaps = 10/282 (3%)
 Frame = +1

Query: 13  FMNVYIGEECEALV---QLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKK 183
           ++  ++ +E +AL+   Q  +A  G     NQ+  +++ N++  +  G+ +    +   +
Sbjct: 160 YLEEHVSKEAKALISRLQELMAGPGHFDPYNQVV-VSVANVIGAMCFGQHFP---ESSDE 215

Query: 184 LCSLVMRLFKLVDM--SGGILNFLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQ 354
           + SLV    + V+   SG  L+F P LR+   P L  F   +  +     +L++ ++EH 
Sbjct: 216 MLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRF---KAFNQRFLWFLQKTVQEHY 272

Query: 355 ENLQLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLH 525
           ++    + +D+  A      +                   +   AG +TVT    + L++
Sbjct: 273 QDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMY 332

Query: 526 VVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           +V   ++QRK+ +E+D +IGR+R   L DR ++ Y EA ILET R S+     IPH    
Sbjct: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR 392

Query: 706 DAKLGNYIIPKGTFILLSLYXLHHGPH-WKDPXTFRPERFLT 828
           D  L  + IPK   + ++ + ++H P  W+DP  FRPERFLT
Sbjct: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434


>L00389-1|AAA35738.1|  516|Homo sapiens protein ( Human cytochrome
           P-450 4 gene, exon 7, and three Alu repeats in the 3'
           flank. ).
          Length = 516

 Score =  118 bits (284), Expect = 3e-26
 Identities = 78/282 (27%), Positives = 139/282 (49%), Gaps = 10/282 (3%)
 Frame = +1

Query: 13  FMNVYIGEECEALV---QLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKK 183
           ++  ++ +E +AL+   Q  +A  G     NQ+  +++ N++  +  G+ +    +   +
Sbjct: 160 YLEEHVSKEAKALISRLQELMAGPGHFDPYNQVV-VSVANVIGAMCFGQHFP---ESSDE 215

Query: 184 LCSLVMRLFKLVDM--SGGILNFLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQ 354
           + SLV    + V+   SG  L+F P LR+   P L  F   +  +     +L++ ++EH 
Sbjct: 216 MLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRF---KAFNQRFLWFLQKTVQEHY 272

Query: 355 ENLQLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLH 525
           ++    + +D+  A      +                   +   AG +TVT    + L++
Sbjct: 273 QDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMY 332

Query: 526 VVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           +V   ++QRK+ +E+D +IGR+R   L DR ++ Y EA ILET R S+     IPH    
Sbjct: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR 392

Query: 706 DAKLGNYIIPKGTFILLSLYXLHHGPH-WKDPXTFRPERFLT 828
           D  L  + IPK   + ++ + ++H P  W+DP  FRPERFLT
Sbjct: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434


>DQ282162-1|ABB77909.1|  500|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 500

 Score =  118 bits (284), Expect = 3e-26
 Identities = 78/256 (30%), Positives = 126/256 (49%), Gaps = 8/256 (3%)
 Frame = +1

Query: 82  PILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSG---GILNFLP 252
           P   N +    + N++  L  G+R++ +D R  +L  L     K  + SG    +LN +P
Sbjct: 174 PFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLK--EESGFLREVLNAVP 231

Query: 253 FLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAP-KDVIDAFLIDMLESQDD 429
            L H +P L G  ++     A    L E++ EH+       P +D+ +AFL +M +++ +
Sbjct: 232 VLLH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGN 288

Query: 430 KXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNH 600
                          +   AGM T + T  + LL ++ + DVQR++ QEIDD+IG+ R  
Sbjct: 289 PESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP 348

Query: 601 LLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYX-LHH 777
            + D+  M YT AVI E  R   +  +G+ HM   D ++  + IPKGT ++ +L   L  
Sbjct: 349 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 408

Query: 778 GPHWKDPXTFRPERFL 825
              W+ P  F PE FL
Sbjct: 409 EAVWEKPFRFHPEHFL 424


>DQ022432-1|AAY26399.1|  516|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 2 protein.
          Length = 516

 Score =  118 bits (284), Expect = 3e-26
 Identities = 78/282 (27%), Positives = 139/282 (49%), Gaps = 10/282 (3%)
 Frame = +1

Query: 13  FMNVYIGEECEALV---QLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKK 183
           ++  ++ +E +AL+   Q  +A  G     NQ+  +++ N++  +  G+ +    +   +
Sbjct: 160 YLEEHVSKEAKALISRLQELMAGPGHFDPYNQVV-VSVANVIGAMCFGQHFP---ESSDE 215

Query: 184 LCSLVMRLFKLVDM--SGGILNFLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQ 354
           + SLV    + V+   SG  L+F P LR+   P L  F   +  +     +L++ ++EH 
Sbjct: 216 MLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRF---KAFNQRFLWFLQKTVQEHY 272

Query: 355 ENLQLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLH 525
           ++    + +D+  A      +                   +   AG +TVT    + L++
Sbjct: 273 QDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMY 332

Query: 526 VVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           +V   ++QRK+ +E+D +IGR+R   L DR ++ Y EA ILET R S+     IPH    
Sbjct: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR 392

Query: 706 DAKLGNYIIPKGTFILLSLYXLHHGPH-WKDPXTFRPERFLT 828
           D  L  + IPK   + ++ + ++H P  W+DP  FRPERFLT
Sbjct: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434


>BC117165-1|AAI17166.1|  494|Homo sapiens cytochrome P450, family 2,
           subfamily A, polypeptide 7 protein.
          Length = 494

 Score =  118 bits (284), Expect = 3e-26
 Identities = 79/273 (28%), Positives = 131/273 (47%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE   L++   +  G  I        T+ N++  +V G R+D ED+    L S+++ +
Sbjct: 149 IQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSVMLGI 208

Query: 208 FKLVDMSGGILN--FLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAP 378
           F+    S G L   F   ++H   P+   F  LQ     L  ++ + ++ +Q  L   +P
Sbjct: 209 FQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQ----GLEDFIAKKVEHNQRTLDPNSP 264

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D ID+FLI M E + +                   AG ETV+ T  +  L ++++ +V+
Sbjct: 265 RDFIDSFLIRMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVE 324

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            K+H+EID +IG++R    +DR +M Y EAVI E  R   V  M +      D K  ++ 
Sbjct: 325 AKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFF 384

Query: 730 IPKGTFILLSLYXLHHGP-HWKDPXTFRPERFL 825
           +PKGT +   L  +   P  + +P  F P+ FL
Sbjct: 385 LPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFL 417


>BC067428-1|AAH67428.1|  516|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 2 protein.
          Length = 516

 Score =  118 bits (284), Expect = 3e-26
 Identities = 78/282 (27%), Positives = 139/282 (49%), Gaps = 10/282 (3%)
 Frame = +1

Query: 13  FMNVYIGEECEALV---QLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKK 183
           ++  ++ +E +AL+   Q  +A  G     NQ+  +++ N++  +  G+ +    +   +
Sbjct: 160 YLEEHVSKEAKALISRLQELMAGPGHFDPYNQVV-VSVANVIGAMCFGQHFP---ESSDE 215

Query: 184 LCSLVMRLFKLVDM--SGGILNFLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQ 354
           + SLV    + V+   SG  L+F P LR+   P L  F   +  +     +L++ ++EH 
Sbjct: 216 MLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRF---KAFNQRFLWFLQKTVQEHY 272

Query: 355 ENLQLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLH 525
           ++    + +D+  A      +                   +   AG +TVT    + L++
Sbjct: 273 QDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMY 332

Query: 526 VVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           +V   ++QRK+ +E+D +IGR+R   L DR ++ Y EA ILET R S+     IPH    
Sbjct: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR 392

Query: 706 DAKLGNYIIPKGTFILLSLYXLHHGPH-WKDPXTFRPERFLT 828
           D  L  + IPK   + ++ + ++H P  W+DP  FRPERFLT
Sbjct: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434


>BC067427-1|AAH67427.1|  516|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 2 protein.
          Length = 516

 Score =  118 bits (284), Expect = 3e-26
 Identities = 78/282 (27%), Positives = 139/282 (49%), Gaps = 10/282 (3%)
 Frame = +1

Query: 13  FMNVYIGEECEALV---QLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKK 183
           ++  ++ +E +AL+   Q  +A  G     NQ+  +++ N++  +  G+ +    +   +
Sbjct: 160 YLEEHVSKEAKALISRLQELMAGPGHFDPYNQVV-VSVANVIGAMCFGQHFP---ESSDE 215

Query: 184 LCSLVMRLFKLVDM--SGGILNFLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQ 354
           + SLV    + V+   SG  L+F P LR+   P L  F   +  +     +L++ ++EH 
Sbjct: 216 MLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRF---KAFNQRFLWFLQKTVQEHY 272

Query: 355 ENLQLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLH 525
           ++    + +D+  A      +                   +   AG +TVT    + L++
Sbjct: 273 QDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMY 332

Query: 526 VVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           +V   ++QRK+ +E+D +IGR+R   L DR ++ Y EA ILET R S+     IPH    
Sbjct: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR 392

Query: 706 DAKLGNYIIPKGTFILLSLYXLHHGPH-WKDPXTFRPERFLT 828
           D  L  + IPK   + ++ + ++H P  W+DP  FRPERFLT
Sbjct: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434


>BC067426-1|AAH67426.1|  516|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 2 protein.
          Length = 516

 Score =  118 bits (284), Expect = 3e-26
 Identities = 78/282 (27%), Positives = 139/282 (49%), Gaps = 10/282 (3%)
 Frame = +1

Query: 13  FMNVYIGEECEALV---QLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKK 183
           ++  ++ +E +AL+   Q  +A  G     NQ+  +++ N++  +  G+ +    +   +
Sbjct: 160 YLEEHVSKEAKALISRLQELMAGPGHFDPYNQVV-VSVANVIGAMCFGQHFP---ESSDE 215

Query: 184 LCSLVMRLFKLVDM--SGGILNFLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQ 354
           + SLV    + V+   SG  L+F P LR+   P L  F   +  +     +L++ ++EH 
Sbjct: 216 MLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRF---KAFNQRFLWFLQKTVQEHY 272

Query: 355 ENLQLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLH 525
           ++    + +D+  A      +                   +   AG +TVT    + L++
Sbjct: 273 QDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMY 332

Query: 526 VVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           +V   ++QRK+ +E+D +IGR+R   L DR ++ Y EA ILET R S+     IPH    
Sbjct: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR 392

Query: 706 DAKLGNYIIPKGTFILLSLYXLHHGPH-WKDPXTFRPERFLT 828
           D  L  + IPK   + ++ + ++H P  W+DP  FRPERFLT
Sbjct: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434


>BC067425-1|AAH67425.1|  516|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 2 protein.
          Length = 516

 Score =  118 bits (284), Expect = 3e-26
 Identities = 78/282 (27%), Positives = 139/282 (49%), Gaps = 10/282 (3%)
 Frame = +1

Query: 13  FMNVYIGEECEALV---QLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKK 183
           ++  ++ +E +AL+   Q  +A  G     NQ+  +++ N++  +  G+ +    +   +
Sbjct: 160 YLEEHVSKEAKALISRLQELMAGPGHFDPYNQVV-VSVANVIGAMCFGQHFP---ESSDE 215

Query: 184 LCSLVMRLFKLVDM--SGGILNFLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQ 354
           + SLV    + V+   SG  L+F P LR+   P L  F   +  +     +L++ ++EH 
Sbjct: 216 MLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRF---KAFNQRFLWFLQKTVQEHY 272

Query: 355 ENLQLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLH 525
           ++    + +D+  A      +                   +   AG +TVT    + L++
Sbjct: 273 QDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMY 332

Query: 526 VVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           +V   ++QRK+ +E+D +IGR+R   L DR ++ Y EA ILET R S+     IPH    
Sbjct: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR 392

Query: 706 DAKLGNYIIPKGTFILLSLYXLHHGPH-WKDPXTFRPERFLT 828
           D  L  + IPK   + ++ + ++H P  W+DP  FRPERFLT
Sbjct: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434


>BC067424-1|AAH67424.1|  516|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 2 protein.
          Length = 516

 Score =  118 bits (284), Expect = 3e-26
 Identities = 78/282 (27%), Positives = 139/282 (49%), Gaps = 10/282 (3%)
 Frame = +1

Query: 13  FMNVYIGEECEALV---QLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKK 183
           ++  ++ +E +AL+   Q  +A  G     NQ+  +++ N++  +  G+ +    +   +
Sbjct: 160 YLEEHVSKEAKALISRLQELMAGPGHFDPYNQVV-VSVANVIGAMCFGQHFP---ESSDE 215

Query: 184 LCSLVMRLFKLVDM--SGGILNFLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQ 354
           + SLV    + V+   SG  L+F P LR+   P L  F   +  +     +L++ ++EH 
Sbjct: 216 MLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRF---KAFNQRFLWFLQKTVQEHY 272

Query: 355 ENLQLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLH 525
           ++    + +D+  A      +                   +   AG +TVT    + L++
Sbjct: 273 QDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMY 332

Query: 526 VVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           +V   ++QRK+ +E+D +IGR+R   L DR ++ Y EA ILET R S+     IPH    
Sbjct: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR 392

Query: 706 DAKLGNYIIPKGTFILLSLYXLHHGPH-WKDPXTFRPERFLT 828
           D  L  + IPK   + ++ + ++H P  W+DP  FRPERFLT
Sbjct: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434


>AF253322-2|AAK25728.1|  516|Homo sapiens cytochrome P450 protein.
          Length = 516

 Score =  118 bits (284), Expect = 3e-26
 Identities = 78/282 (27%), Positives = 139/282 (49%), Gaps = 10/282 (3%)
 Frame = +1

Query: 13  FMNVYIGEECEALV---QLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKK 183
           ++  ++ +E +AL+   Q  +A  G     NQ+  +++ N++  +  G+ +    +   +
Sbjct: 160 YLEEHVSKEAKALISRLQELMAGPGHFDPYNQVV-VSVANVIGAMCFGQHFP---ESSDE 215

Query: 184 LCSLVMRLFKLVDM--SGGILNFLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQ 354
           + SLV    + V+   SG  L+F P LR+   P L  F   +  +     +L++ ++EH 
Sbjct: 216 MLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRF---KAFNQRFLWFLQKTVQEHY 272

Query: 355 ENLQLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLH 525
           ++    + +D+  A      +                   +   AG +TVT    + L++
Sbjct: 273 QDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMY 332

Query: 526 VVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           +V   ++QRK+ +E+D +IGR+R   L DR ++ Y EA ILET R S+     IPH    
Sbjct: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR 392

Query: 706 DAKLGNYIIPKGTFILLSLYXLHHGPH-WKDPXTFRPERFLT 828
           D  L  + IPK   + ++ + ++H P  W+DP  FRPERFLT
Sbjct: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434


>L16876-1|AAA02630.1|  490|Homo sapiens cytochrome P-4502C18
           protein.
          Length = 490

 Score =  118 bits (283), Expect = 3e-26
 Identities = 79/272 (29%), Positives = 131/272 (48%), Gaps = 6/272 (2%)
 Frame = +1

Query: 28  IGEECEALVQ-LRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
           + EE   LV+ LR  +A  P     +      N++  ++   R+D +DQR   L      
Sbjct: 145 VQEEARCLVEELRKTNAS-PCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNE 203

Query: 205 LFKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPK 381
             +++      + N  P L  ++P      ++ E    +  Y+ E IKEHQE+L + + +
Sbjct: 204 NLRILSSPWIQVCNNFPALIDYLPG--SHNKIAENFAYIKSYVLERIKEHQESLDMNSAR 261

Query: 382 DVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQR 552
           D ID FLI M + + ++              +   AG ET + T  + LL +++  +V  
Sbjct: 262 DFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTA 321

Query: 553 KLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYII 732
           K+ +EI+ ++GR+R+  + DR  M YT+AV+ E  R   +    +PH    D K  NY+I
Sbjct: 322 KVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLI 381

Query: 733 PKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           PKG  I+ SL   LH+   + +P  F P  FL
Sbjct: 382 PKGMTIITSLTSVLHNDKEFPNPEMFDPGHFL 413


>BC067429-1|AAH67429.1|  516|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 2 protein.
          Length = 516

 Score =  117 bits (282), Expect = 5e-26
 Identities = 78/282 (27%), Positives = 138/282 (48%), Gaps = 10/282 (3%)
 Frame = +1

Query: 13  FMNVYIGEECEALV---QLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKK 183
           ++  ++ +E +AL+   Q  +A  G     NQ+  +++ N++  +  G+ +    +   +
Sbjct: 160 YLEEHVSKEAKALISRLQELMAGPGHFDPYNQVV-VSVANVIGAMCFGQHFP---ESSDE 215

Query: 184 LCSLVMRLFKLVDM--SGGILNFLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQ 354
           + SLV    + V+   SG  L+F P LR+   P L  F   +  +     +L++ ++EH 
Sbjct: 216 MLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRF---KAFNQRFLWFLQKTVQEHY 272

Query: 355 ENLQLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLH 525
           ++    + +D+  A      +                   +   AG +TVT    + L++
Sbjct: 273 QDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMY 332

Query: 526 VVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           +V   ++QRK+ +E+D +IGR+R   L DR ++ Y EA ILET R S      IPH    
Sbjct: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSPFLPFTIPHSTTR 392

Query: 706 DAKLGNYIIPKGTFILLSLYXLHHGPH-WKDPXTFRPERFLT 828
           D  L  + IPK   + ++ + ++H P  W+DP  FRPERFLT
Sbjct: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434


>AF182274-1|AAF13599.1|  516|Homo sapiens cytochrome P450-1A2
           protein.
          Length = 516

 Score =  117 bits (281), Expect = 6e-26
 Identities = 78/282 (27%), Positives = 138/282 (48%), Gaps = 10/282 (3%)
 Frame = +1

Query: 13  FMNVYIGEECEALV---QLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKK 183
           ++  ++ +E  AL+   Q  +A  G     NQ+  +++ N++  +  G+ +    +   +
Sbjct: 160 YLEEHVSKEAMALISRLQELMAGPGHFDPYNQVV-VSVANVIGAMCFGQHFP---ESSDE 215

Query: 184 LCSLVMRLFKLVDM--SGGILNFLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQ 354
           + SLV    + V+   SG  L+F P LR+   P L  F   +  +     +L++ ++EH 
Sbjct: 216 MLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRF---KAFNQRFLWFLQKTVQEHY 272

Query: 355 ENLQLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLH 525
           ++    + +D+  A      +                   +   AG +TVT    + L++
Sbjct: 273 QDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDVFGAGFDTVTTAISWSLMY 332

Query: 526 VVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           +V   ++QRK+ +E+D +IGR+R   L DR ++ Y EA ILET R S+     IPH    
Sbjct: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR 392

Query: 706 DAKLGNYIIPKGTFILLSLYXLHHGPH-WKDPXTFRPERFLT 828
           D  L  + IPK   + ++ + ++H P  W+DP  FRPERFLT
Sbjct: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434


>AB209492-1|BAD92729.1|  566|Homo sapiens Debrisoquine 4-hydroxylase
           mutant allele variant protein.
          Length = 566

 Score =  116 bits (279), Expect = 1e-25
 Identities = 76/243 (31%), Positives = 122/243 (50%), Gaps = 8/243 (3%)
 Frame = +1

Query: 121 NILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSG---GILNFLPFLRHFVPRLIGFT 291
           N++  L  G+R++ +D R  +L  L     K  + SG    +LN +P L H +P L G  
Sbjct: 253 NVIASLTCGRRFEYDDPRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLH-IPALAG-- 307

Query: 292 ELQEIHNALHQYLREIIKEHQENLQLGAP-KDVIDAFLIDMLESQDDKXXXXXXXXXXXX 468
           ++     A    L E++ EH+       P +D+ +AFL +M +++ +             
Sbjct: 308 KVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIV 367

Query: 469 XXE---AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEA 639
             +   AGM T + T  + LL ++ + DVQR++ QEIDD+IG+ R   + D+  M YT A
Sbjct: 368 VADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTA 427

Query: 640 VILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYX-LHHGPHWKDPXTFRPE 816
           VI E  R   +  +G+ HM   D ++  + IPKGT ++ +L   L     W+ P  F PE
Sbjct: 428 VIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPE 487

Query: 817 RFL 825
            FL
Sbjct: 488 HFL 490


>BC104909-1|AAI04910.1|  501|Homo sapiens cytochrome P450, family 2,
           subfamily R, polypeptide 1 protein.
          Length = 501

 Score =  116 bits (278), Expect = 1e-25
 Identities = 75/258 (29%), Positives = 128/258 (49%), Gaps = 8/258 (3%)
 Frame = +1

Query: 76  GEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGIL-NFLP 252
           G P    Q+    + NI   ++ G+R+  ED   + +  L     +L   +   L N  P
Sbjct: 174 GRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFP 233

Query: 253 FLRHFVPRLIGFTELQEI-HNA--LHQYLREIIKEHQENLQLGAPKDVIDAFLIDMLESQ 423
           ++      ++ F + Q++  NA  ++ +L  +I++   N +   P+  +DA+L +M + +
Sbjct: 234 WIG-----ILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGK 288

Query: 424 DDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDR 594
           +D               E   AG ET TN   + +L +    ++Q ++ +EID I+G + 
Sbjct: 289 NDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNG 348

Query: 595 NHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLH 774
               DD+ +M YTEAV+ E LR   +  +GI H    DA +  Y IPKGT ++ +LY +H
Sbjct: 349 KPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVH 408

Query: 775 HG-PHWKDPXTFRPERFL 825
               +W+DP  F PERFL
Sbjct: 409 FDEKYWRDPEVFHPERFL 426


>BC104907-1|AAI04908.1|  501|Homo sapiens cytochrome P450, family 2,
           subfamily R, polypeptide 1 protein.
          Length = 501

 Score =  116 bits (278), Expect = 1e-25
 Identities = 75/258 (29%), Positives = 128/258 (49%), Gaps = 8/258 (3%)
 Frame = +1

Query: 76  GEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGIL-NFLP 252
           G P    Q+    + NI   ++ G+R+  ED   + +  L     +L   +   L N  P
Sbjct: 174 GRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFP 233

Query: 253 FLRHFVPRLIGFTELQEI-HNA--LHQYLREIIKEHQENLQLGAPKDVIDAFLIDMLESQ 423
           ++      ++ F + Q++  NA  ++ +L  +I++   N +   P+  +DA+L +M + +
Sbjct: 234 WIG-----ILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGK 288

Query: 424 DDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDR 594
           +D               E   AG ET TN   + +L +    ++Q ++ +EID I+G + 
Sbjct: 289 NDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNG 348

Query: 595 NHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLH 774
               DD+ +M YTEAV+ E LR   +  +GI H    DA +  Y IPKGT ++ +LY +H
Sbjct: 349 KPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVH 408

Query: 775 HG-PHWKDPXTFRPERFL 825
               +W+DP  F PERFL
Sbjct: 409 FDEKYWRDPEVFHPERFL 426


>AY323817-1|AAQ23114.1|  501|Homo sapiens cytochrome P450 2R1
           protein.
          Length = 501

 Score =  116 bits (278), Expect = 1e-25
 Identities = 75/258 (29%), Positives = 128/258 (49%), Gaps = 8/258 (3%)
 Frame = +1

Query: 76  GEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGIL-NFLP 252
           G P    Q+    + NI   ++ G+R+  ED   + +  L     +L   +   L N  P
Sbjct: 174 GRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFP 233

Query: 253 FLRHFVPRLIGFTELQEI-HNA--LHQYLREIIKEHQENLQLGAPKDVIDAFLIDMLESQ 423
           ++      ++ F + Q++  NA  ++ +L  +I++   N +   P+  +DA+L +M + +
Sbjct: 234 WIG-----ILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGK 288

Query: 424 DDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDR 594
           +D               E   AG ET TN   + +L +    ++Q ++ +EID I+G + 
Sbjct: 289 NDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNG 348

Query: 595 NHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLH 774
               DD+ +M YTEAV+ E LR   +  +GI H    DA +  Y IPKGT ++ +LY +H
Sbjct: 349 KPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVH 408

Query: 775 HG-PHWKDPXTFRPERFL 825
               +W+DP  F PERFL
Sbjct: 409 FDEKYWRDPEVFHPERFL 426


>AB209700-1|BAD92937.1|  336|Homo sapiens cytochrome P450, family 2,
           subfamily E, polypeptide 1 variant protein.
          Length = 336

 Score =  115 bits (277), Expect = 2e-25
 Identities = 74/266 (27%), Positives = 125/266 (46%), Gaps = 7/266 (2%)
 Frame = +1

Query: 49  LVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMS 228
           LV L     G+P     +      N++  ++  K +D  D++  +L  L    F L+   
Sbjct: 50  LVALTACFVGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTP 109

Query: 229 G-GILNFLPFLRHFVPRLIGFTELQEIHNA--LHQYLREIIKEHQENLQLGAPKDVIDAF 399
              + N  P   H++P     +  + I N   + +Y+ E +KEH ++L    P+D+ D  
Sbjct: 110 WLQLYNNFPSFLHYLPG----SHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCL 165

Query: 400 LIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQRKLHQEI 570
           L++M + +                 +   AG ET + T  + LL +++  +++ KLH+EI
Sbjct: 166 LVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEI 225

Query: 571 DDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFI 750
           D +IG  R   + DR  M Y +AV+ E  R  T+    +PH A  D     Y+IPKGT +
Sbjct: 226 DRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVV 285

Query: 751 LLSL-YXLHHGPHWKDPXTFRPERFL 825
           + +L   L+    + DP  F+PE FL
Sbjct: 286 VPTLDSVLYDNQEFPDPEKFKPEHFL 311


>BC067433-1|AAH67433.1|  493|Homo sapiens cytochrome P450, family 2,
           subfamily E, polypeptide 1 protein.
          Length = 493

 Score =  115 bits (276), Expect = 2e-25
 Identities = 74/273 (27%), Positives = 127/273 (46%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I  E   L++      G+P     +      N++  ++  K +D  D++  +L  L    
Sbjct: 147 IQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNEN 206

Query: 208 FKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNA--LHQYLREIIKEHQENLQLGAP 378
           F L+      + N  P   H++P     +  + I N   + +Y+ E +KEH ++L    P
Sbjct: 207 FHLLSTPWLQLYNNFPSFLHYLPG----SHRKVIKNVAEVKEYVSERVKEHHQSLDPNCP 262

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D+ D  L++M + +                 +   AG ET + T  + LL +++  +++
Sbjct: 263 RDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIE 322

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            KLH+EID +IG  R   + DR  M Y +AV+ E  R  T+    +PH A  D     Y+
Sbjct: 323 EKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVREIQRFITLVPSNLPHEATRDTIFRGYL 382

Query: 730 IPKGTFILLSL-YXLHHGPHWKDPXTFRPERFL 825
           IPKGT ++ +L   L+    + DP  F+PE FL
Sbjct: 383 IPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415


>AF182276-1|AAF13601.1|  493|Homo sapiens cytochrome P450-2E1
           protein.
          Length = 493

 Score =  115 bits (276), Expect = 2e-25
 Identities = 74/273 (27%), Positives = 127/273 (46%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I  E   L++      G+P     +      N++  ++  K +D  D++  +L  L    
Sbjct: 147 IQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNEN 206

Query: 208 FKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNA--LHQYLREIIKEHQENLQLGAP 378
           F L+      + N  P   H++P     +  + I N   + +Y+ E +KEH ++L    P
Sbjct: 207 FHLLSTPWLQLYNNFPSFLHYLPG----SHRKAIKNVAEVKEYVSERVKEHHQSLDPNCP 262

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D+ D  L++M + +                 +   AG ET + T  + LL +++  +++
Sbjct: 263 RDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIE 322

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            KLH+EID +IG  R   + DR  M Y +AV+ E  R  T+    +PH A  D     Y+
Sbjct: 323 EKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYL 382

Query: 730 IPKGTFILLSL-YXLHHGPHWKDPXTFRPERFL 825
           IPKGT ++ +L   L+    + DP  F+PE FL
Sbjct: 383 IPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415


>J02843-1|AAA52155.1|  493|Homo sapiens protein ( Human cytochrome
           P450IIE1 (ethanol-inducible) gene, complete cds. ).
          Length = 493

 Score =  114 bits (275), Expect = 3e-25
 Identities = 74/273 (27%), Positives = 127/273 (46%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I  E   L++      G+P     +      N++  ++  K +D  D++  +L  L    
Sbjct: 147 IQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNEN 206

Query: 208 FKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNA--LHQYLREIIKEHQENLQLGAP 378
           F L+      + N  P   H++P     +  + I N   + +Y+ E +KEH ++L    P
Sbjct: 207 FHLLSTPWLQLYNNFPSFLHYLPG----SHRKVIKNVAEVKEYVSERVKEHHQSLDPNCP 262

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D+ D  L++M + +                 +   AG ET + T  + LL +++  +++
Sbjct: 263 RDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIE 322

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            KLH+EID +IG  R   + DR  M Y +AV+ E  R  T+    +PH A  D     Y+
Sbjct: 323 EKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYL 382

Query: 730 IPKGTFILLSL-YXLHHGPHWKDPXTFRPERFL 825
           IPKGT ++ +L   L+    + DP  F+PE FL
Sbjct: 383 IPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415


>J02625-1|AAA35743.1|  493|Homo sapiens protein ( Human cytochrome
           P-450j mRNA, complete cds. ).
          Length = 493

 Score =  114 bits (275), Expect = 3e-25
 Identities = 74/273 (27%), Positives = 127/273 (46%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I  E   L++      G+P     +      N++  ++  K +D  D++  +L  L    
Sbjct: 147 IQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNEN 206

Query: 208 FKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNA--LHQYLREIIKEHQENLQLGAP 378
           F L+      + N  P   H++P     +  + I N   + +Y+ E +KEH ++L    P
Sbjct: 207 FHLLSTPWLQLYNNFPSFLHYLPG----SHRKVIKNVAEVKEYVSERVKEHHQSLDPNCP 262

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D+ D  L++M + +                 +   AG ET + T  + LL +++  +++
Sbjct: 263 RDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIE 322

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            KLH+EID +IG  R   + DR  M Y +AV+ E  R  T+    +PH A  D     Y+
Sbjct: 323 EKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYL 382

Query: 730 IPKGTFILLSL-YXLHHGPHWKDPXTFRPERFL 825
           IPKGT ++ +L   L+    + DP  F+PE FL
Sbjct: 383 IPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415


>DQ515958-1|ABF47105.1|  493|Homo sapiens cytochrome P450, family 2,
           subfamily E, polypeptide 1 protein.
          Length = 493

 Score =  114 bits (275), Expect = 3e-25
 Identities = 74/273 (27%), Positives = 127/273 (46%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I  E   L++      G+P     +      N++  ++  K +D  D++  +L  L    
Sbjct: 147 IQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNEN 206

Query: 208 FKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNA--LHQYLREIIKEHQENLQLGAP 378
           F L+      + N  P   H++P     +  + I N   + +Y+ E +KEH ++L    P
Sbjct: 207 FHLLSTPWLQLYNNFPSFLHYLPG----SHRKVIKNVAEVKEYVSERVKEHHQSLDPNCP 262

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D+ D  L++M + +                 +   AG ET + T  + LL +++  +++
Sbjct: 263 RDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIE 322

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            KLH+EID +IG  R   + DR  M Y +AV+ E  R  T+    +PH A  D     Y+
Sbjct: 323 EKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYL 382

Query: 730 IPKGTFILLSL-YXLHHGPHWKDPXTFRPERFL 825
           IPKGT ++ +L   L+    + DP  F+PE FL
Sbjct: 383 IPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415


>DQ149222-1|AAZ77710.1|  493|Homo sapiens cytochrome P450 2E1
           protein.
          Length = 493

 Score =  114 bits (275), Expect = 3e-25
 Identities = 74/273 (27%), Positives = 127/273 (46%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I  E   L++      G+P     +      N++  ++  K +D  D++  +L  L    
Sbjct: 147 IQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNEN 206

Query: 208 FKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNA--LHQYLREIIKEHQENLQLGAP 378
           F L+      + N  P   H++P     +  + I N   + +Y+ E +KEH ++L    P
Sbjct: 207 FHLLSTPWLQLYNNFPSFLHYLPG----SHRKVIKNVAEVKEYVSERVKEHHQSLDPNCP 262

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D+ D  L++M + +                 +   AG ET + T  + LL +++  +++
Sbjct: 263 RDLADCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIE 322

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            KLH+EID +IG  R   + DR  M Y +AV+ E  R  T+    +PH A  D     Y+
Sbjct: 323 EKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYL 382

Query: 730 IPKGTFILLSL-YXLHHGPHWKDPXTFRPERFL 825
           IPKGT ++ +L   L+    + DP  F+PE FL
Sbjct: 383 IPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415


>BC067435-1|AAH67435.1|  493|Homo sapiens cytochrome P450, family 2,
           subfamily E, polypeptide 1 protein.
          Length = 493

 Score =  114 bits (275), Expect = 3e-25
 Identities = 74/273 (27%), Positives = 127/273 (46%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I  E   L++      G+P     +      N++  ++  K +D  D++  +L  L    
Sbjct: 147 IQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNEN 206

Query: 208 FKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNA--LHQYLREIIKEHQENLQLGAP 378
           F L+      + N  P   H++P     +  + I N   + +Y+ E +KEH ++L    P
Sbjct: 207 FHLLSTPWLQLYNNFPSFLHYLPG----SHRKVIKNVAEVKEYVSERVKEHHQSLDPNCP 262

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D+ D  L++M + +                 +   AG ET + T  + LL +++  +++
Sbjct: 263 RDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIE 322

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            KLH+EID +IG  R   + DR  M Y +AV+ E  R  T+    +PH A  D     Y+
Sbjct: 323 EKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYL 382

Query: 730 IPKGTFILLSL-YXLHHGPHWKDPXTFRPERFL 825
           IPKGT ++ +L   L+    + DP  F+PE FL
Sbjct: 383 IPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415


>AL161645-2|CAH70047.1|  493|Homo sapiens cytochrome P450, family 2,
           subfamily E, polypeptide 1 protein.
          Length = 493

 Score =  114 bits (275), Expect = 3e-25
 Identities = 74/273 (27%), Positives = 127/273 (46%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I  E   L++      G+P     +      N++  ++  K +D  D++  +L  L    
Sbjct: 147 IQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNEN 206

Query: 208 FKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNA--LHQYLREIIKEHQENLQLGAP 378
           F L+      + N  P   H++P     +  + I N   + +Y+ E +KEH ++L    P
Sbjct: 207 FHLLSTPWLQLYNNFPSFLHYLPG----SHRKVIKNVAEVKEYVSERVKEHHQSLDPNCP 262

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D+ D  L++M + +                 +   AG ET + T  + LL +++  +++
Sbjct: 263 RDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIE 322

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            KLH+EID +IG  R   + DR  M Y +AV+ E  R  T+    +PH A  D     Y+
Sbjct: 323 EKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYL 382

Query: 730 IPKGTFILLSL-YXLHHGPHWKDPXTFRPERFL 825
           IPKGT ++ +L   L+    + DP  F+PE FL
Sbjct: 383 IPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415


>AF084225-1|AAD13753.1|  462|Homo sapiens cytochrome P450 2E1
           protein.
          Length = 462

 Score =  114 bits (275), Expect = 3e-25
 Identities = 74/273 (27%), Positives = 127/273 (46%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I  E   L++      G+P     +      N++  ++  K +D  D++  +L  L    
Sbjct: 116 IQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNEN 175

Query: 208 FKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNA--LHQYLREIIKEHQENLQLGAP 378
           F L+      + N  P   H++P     +  + I N   + +Y+ E +KEH ++L    P
Sbjct: 176 FHLLSTPWLQLYNNFPSFLHYLPG----SHRKVIKNVAEVKEYVSERVKEHHQSLDPNCP 231

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D+ D  L++M + +                 +   AG ET + T  + LL +++  +++
Sbjct: 232 RDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIE 291

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            KLH+EID +IG  R   + DR  M Y +AV+ E  R  T+    +PH A  D     Y+
Sbjct: 292 EKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYL 351

Query: 730 IPKGTFILLSL-YXLHHGPHWKDPXTFRPERFL 825
           IPKGT ++ +L   L+    + DP  F+PE FL
Sbjct: 352 IPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 384


>X13930-1|CAA32118.1|  494|Homo sapiens protein ( Human CYP2A4 mRNA
           for P-450 IIA4 protein. ).
          Length = 494

 Score =  114 bits (274), Expect = 4e-25
 Identities = 76/273 (27%), Positives = 127/273 (46%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE   L+       G  I        T+ N++  +V G R+D +D+    L  +++ +
Sbjct: 149 IQEEAGFLIDAHRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGI 208

Query: 208 FKLVDMSGGILN--FLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAP 378
           F+    S G L   F   ++H   P+   F  LQ     L  ++ + ++ +Q  L   +P
Sbjct: 209 FQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQ----GLEDFIAKKVEHNQRTLDPNSP 264

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D ID+FLI M E + +                    G ETV+ T  +  L ++++ +V+
Sbjct: 265 RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVE 324

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            K+H+EID +IG++R    +DR +M Y EAVI E  R   V  M +      D K  ++ 
Sbjct: 325 AKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFF 384

Query: 730 IPKGTFILLSLYXLHHGP-HWKDPXTFRPERFL 825
           +PKGT +   L  +   P  + +P  F P+ FL
Sbjct: 385 LPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFL 417


>BC096255-1|AAH96255.1|  494|Homo sapiens cytochrome P450, family 2,
           subfamily A, polypeptide 6 protein.
          Length = 494

 Score =  114 bits (274), Expect = 4e-25
 Identities = 76/273 (27%), Positives = 127/273 (46%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE   L+       G  I        T+ N++  +V G R+D +D+    L  +++ +
Sbjct: 149 IQEEAGFLIDAHRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGI 208

Query: 208 FKLVDMSGGILN--FLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAP 378
           F+    S G L   F   ++H   P+   F  LQ     L  ++ + ++ +Q  L   +P
Sbjct: 209 FQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQ----GLEDFIAKKVEHNQRTLDPNSP 264

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D ID+FLI M E + +                    G ETV+ T  +  L ++++ +V+
Sbjct: 265 RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVE 324

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            K+H+EID +IG++R    +DR +M Y EAVI E  R   V  M +      D K  ++ 
Sbjct: 325 AKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFF 384

Query: 730 IPKGTFILLSLYXLHHGP-HWKDPXTFRPERFL 825
           +PKGT +   L  +   P  + +P  F P+ FL
Sbjct: 385 LPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFL 417


>AY310359-1|AAQ76692.1|  484|Homo sapiens cytochrome P450 1A1
           variant protein.
          Length = 484

 Score =  114 bits (274), Expect = 4e-25
 Identities = 59/190 (31%), Positives = 97/190 (51%), Gaps = 6/190 (3%)
 Frame = +1

Query: 277 LIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKDVIDAFLIDMLESQDDKXXXXXXXX 456
           L+     ++++   + ++++++KEH +  + G  +D+ D+ +    E Q D+        
Sbjct: 217 LVNLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSD 276

Query: 457 XXXXXXE-----AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIR 621
                       AG +TVT    + L+++V N  VQRK+ +E+D +IGR R   L DR  
Sbjct: 277 EKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSH 336

Query: 622 MVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGPH-WKDP 798
           + Y EA ILET R S+     IPH    D  L  + IPKG  + ++ + ++H    W +P
Sbjct: 337 LPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNP 396

Query: 799 XTFRPERFLT 828
             F PERFLT
Sbjct: 397 SEFLPERFLT 406


>AF372573-1|AAL69652.1|  495|Homo sapiens cytochrome P450 2F1
           protein.
          Length = 495

 Score =  114 bits (274), Expect = 4e-25
 Identities = 76/268 (28%), Positives = 125/268 (46%), Gaps = 9/268 (3%)
 Frame = +1

Query: 49  LVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMS 228
           L +LR  + GEP     +   ++ NI+  ++ G R+D +D+RL  +  L+   F+++   
Sbjct: 154 LAELRKTE-GEPFDPTFVLSRSVSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSP 212

Query: 229 GGILNFL-----PFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKDVID 393
            G L  +     P L  +VP       + +    L   +   + +HQ +L   +P+D I 
Sbjct: 213 WGELYDILDPRFPSLLDWVPG--PHQRIFQNFKCLRDLIAHSVHDHQASLDPRSPRDFIH 270

Query: 394 AFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQRKLHQ 564
            FL  M E ++D                    G +TV+ T     L +++   VQ ++ +
Sbjct: 271 CFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTVSTTLHHAFLALMKYPKVQARVQE 330

Query: 565 EIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGT 744
           EID ++GR R   L DR  M YT+AVI E  R + +  M +PH    D     ++IPKGT
Sbjct: 331 EIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADIIPMNLPHRVTRDTAFRGFLIPKGT 390

Query: 745 FILLSLYXLHHGP-HWKDPXTFRPERFL 825
            ++  L  +H+ P  +  P  F PE FL
Sbjct: 391 DVITLLNTVHYDPSQFLTPQEFNPEHFL 418


>X13929-1|CAA32117.1|  448|Homo sapiens P-450 IIA3 protein (1 is 3rd
           base in codon) protein.
          Length = 448

 Score =  113 bits (272), Expect = 7e-25
 Identities = 76/273 (27%), Positives = 127/273 (46%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE   L+       G  I        T+ N++  +V G R+D +D+    L  +++ +
Sbjct: 103 IQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGI 162

Query: 208 FKLVDMSGGILN--FLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAP 378
           F+    S G L   F   ++H   P+   F  LQ     L  ++ + ++ +Q  L   +P
Sbjct: 163 FQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQ----GLEDFIAKKVEHNQRTLDPNSP 218

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D ID+FLI M E + +                    G ETV+ T  +  L ++++ +V+
Sbjct: 219 RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVE 278

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            K+H+EID +IG++R    +DR +M Y EAVI E  R   V  M +      D K  ++ 
Sbjct: 279 AKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFF 338

Query: 730 IPKGTFILLSLYXLHHGP-HWKDPXTFRPERFL 825
           +PKGT +   L  +   P  + +P  F P+ FL
Sbjct: 339 LPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFL 371


>U22029-1|AAB40520.1|  494|Homo sapiens cytochrome P450 protein.
          Length = 494

 Score =  113 bits (272), Expect = 7e-25
 Identities = 78/273 (28%), Positives = 129/273 (47%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE   L++   +  G  I        T+ N++  +V G R+D ED+    L S+++ +
Sbjct: 149 IQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGI 208

Query: 208 FKLVDMSGGILN--FLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAP 378
           F+    S G L   F   ++H   P+   F  L      L  ++ + ++ +Q  L   +P
Sbjct: 209 FQFTSTSTGQLYEMFSSLMKHLPGPQQQAFKLLL----GLEDFIAKKVEHNQRTLDPNSP 264

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D ID+FLI M E + +                   AG ETV+ T  +  L ++++ +V+
Sbjct: 265 QDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVE 324

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            K+H+EID +IG++R    +DR +M Y EAVI E  R   V  M +      D K  ++ 
Sbjct: 325 AKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFF 384

Query: 730 IPKGTFILLSL-YXLHHGPHWKDPXTFRPERFL 825
           +PKGT +   L   L     + +P  F P+ FL
Sbjct: 385 LPKGTEVFPMLGSVLRDLRFFSNPRDFNPQHFL 417


>M33318-1|AAA52067.1|  494|Homo sapiens CYP2A protein.
          Length = 494

 Score =  113 bits (272), Expect = 7e-25
 Identities = 76/273 (27%), Positives = 127/273 (46%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE   L+       G  I        T+ N++  +V G R+D +D+    L  +++ +
Sbjct: 149 IQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGI 208

Query: 208 FKLVDMSGGILN--FLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAP 378
           F+    S G L   F   ++H   P+   F  LQ     L  ++ + ++ +Q  L   +P
Sbjct: 209 FQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQ----GLEDFIAKKVEHNQRTLDPNSP 264

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D ID+FLI M E + +                    G ETV+ T  +  L ++++ +V+
Sbjct: 265 RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVE 324

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            K+H+EID +IG++R    +DR +M Y EAVI E  R   V  M +      D K  ++ 
Sbjct: 325 AKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFF 384

Query: 730 IPKGTFILLSLYXLHHGP-HWKDPXTFRPERFL 825
           +PKGT +   L  +   P  + +P  F P+ FL
Sbjct: 385 LPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFL 417


>BC096256-1|AAH96256.1|  494|Homo sapiens cytochrome P450, family 2,
           subfamily A, polypeptide 6 protein.
          Length = 494

 Score =  113 bits (272), Expect = 7e-25
 Identities = 76/273 (27%), Positives = 127/273 (46%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE   L+       G  I        T+ N++  +V G R+D +D+    L  +++ +
Sbjct: 149 IQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGI 208

Query: 208 FKLVDMSGGILN--FLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAP 378
           F+    S G L   F   ++H   P+   F  LQ     L  ++ + ++ +Q  L   +P
Sbjct: 209 FQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQ----GLEDFIAKKVEHNQRTLDPNSP 264

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D ID+FLI M E + +                    G ETV+ T  +  L ++++ +V+
Sbjct: 265 RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVE 324

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            K+H+EID +IG++R    +DR +M Y EAVI E  R   V  M +      D K  ++ 
Sbjct: 325 AKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFF 384

Query: 730 IPKGTFILLSLYXLHHGP-HWKDPXTFRPERFL 825
           +PKGT +   L  +   P  + +P  F P+ FL
Sbjct: 385 LPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFL 417


>BC096254-1|AAH96254.1|  494|Homo sapiens cytochrome P450, family 2,
           subfamily A, polypeptide 6 protein.
          Length = 494

 Score =  113 bits (272), Expect = 7e-25
 Identities = 76/273 (27%), Positives = 127/273 (46%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE   L+       G  I        T+ N++  +V G R+D +D+    L  +++ +
Sbjct: 149 IQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGI 208

Query: 208 FKLVDMSGGILN--FLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAP 378
           F+    S G L   F   ++H   P+   F  LQ     L  ++ + ++ +Q  L   +P
Sbjct: 209 FQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQ----GLEDFIAKKVEHNQRTLDPNSP 264

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D ID+FLI M E + +                    G ETV+ T  +  L ++++ +V+
Sbjct: 265 RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVE 324

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            K+H+EID +IG++R    +DR +M Y EAVI E  R   V  M +      D K  ++ 
Sbjct: 325 AKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFF 384

Query: 730 IPKGTFILLSLYXLHHGP-HWKDPXTFRPERFL 825
           +PKGT +   L  +   P  + +P  F P+ FL
Sbjct: 385 LPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFL 417


>BC096253-1|AAH96253.3|  494|Homo sapiens cytochrome P450, family 2,
           subfamily A, polypeptide 6 protein.
          Length = 494

 Score =  113 bits (272), Expect = 7e-25
 Identities = 76/273 (27%), Positives = 127/273 (46%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE   L+       G  I        T+ N++  +V G R+D +D+    L  +++ +
Sbjct: 149 IQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGI 208

Query: 208 FKLVDMSGGILN--FLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAP 378
           F+    S G L   F   ++H   P+   F  LQ     L  ++ + ++ +Q  L   +P
Sbjct: 209 FQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQ----GLEDFIAKKVEHNQRTLDPNSP 264

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D ID+FLI M E + +                    G ETV+ T  +  L ++++ +V+
Sbjct: 265 RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVE 324

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            K+H+EID +IG++R    +DR +M Y EAVI E  R   V  M +      D K  ++ 
Sbjct: 325 AKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFF 384

Query: 730 IPKGTFILLSLYXLHHGP-HWKDPXTFRPERFL 825
           +PKGT +   L  +   P  + +P  F P+ FL
Sbjct: 385 LPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFL 417


>AF182275-1|AAF13600.1|  494|Homo sapiens cytochrome P450-2A6
           protein.
          Length = 494

 Score =  113 bits (272), Expect = 7e-25
 Identities = 76/273 (27%), Positives = 127/273 (46%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE   L+       G  I        T+ N++  +V G R+D +D+    L  +++ +
Sbjct: 149 IQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGI 208

Query: 208 FKLVDMSGGILN--FLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAP 378
           F+    S G L   F   ++H   P+   F  LQ     L  ++ + ++ +Q  L   +P
Sbjct: 209 FQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQ----GLEDFIAKKVEHNQRTLDPNSP 264

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D ID+FLI M E + +                    G ETV+ T  +  L ++++ +V+
Sbjct: 265 RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVE 324

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            K+H+EID +IG++R    +DR +M Y EAVI E  R   V  M +      D K  ++ 
Sbjct: 325 AKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFF 384

Query: 730 IPKGTFILLSLYXLHHGP-HWKDPXTFRPERFL 825
           +PKGT +   L  +   P  + +P  F P+ FL
Sbjct: 385 LPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFL 417


>M17398-1|AAA35740.1|  393|Homo sapiens protein ( Human cytochrome
           P-450 1 mRNA, complete cds, clone Hp1-2. ).
          Length = 393

 Score =  112 bits (269), Expect = 2e-24
 Identities = 72/243 (29%), Positives = 115/243 (47%), Gaps = 6/243 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           + EE   LV+        P     +      N++  +V  KR+D +DQ    L       
Sbjct: 145 VQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNEN 204

Query: 208 FKLVDMSG-GILNFLPFLRHFVPRLIGFTELQEIHNAL--HQYLREIIKEHQENLQLGAP 378
           F++++     + N  P L    P     T  + + N      Y+RE +KEHQ +L +  P
Sbjct: 205 FRILNSPWIQVCNNFPLLIDCFPG----THNKVLKNVALTRSYIREKVKEHQASLDVNNP 260

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D +D FLI M + +D++              +   AG ET + T  + LL ++++ +V 
Sbjct: 261 RDFMDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVT 320

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            K+ +EID +IGR R+  + DR  M YT+AV+ E  R S +   G+PH    D K  NY+
Sbjct: 321 AKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYL 380

Query: 730 IPK 738
           IPK
Sbjct: 381 IPK 383


>X13897-1|CAA32097.1|  489|Homo sapiens protein ( Human mRNA for
           cytochrome P-450IIA. ).
          Length = 489

 Score =  111 bits (266), Expect = 4e-24
 Identities = 75/273 (27%), Positives = 126/273 (46%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE   L+       G  I        T+ N++  +V G R+D +D+    L  +++ +
Sbjct: 144 IQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGI 203

Query: 208 FKLVDMSGGILN--FLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAP 378
           F+    S G L   F   ++H   P+   F  LQ     L  ++ + ++  Q  L   +P
Sbjct: 204 FQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQ----GLEDFIAKKVEHKQRTLDPNSP 259

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D ID+FLI M E + +                    G ETV+ T  +  L ++++ +V+
Sbjct: 260 RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVE 319

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            ++H+EID +IG++R    +DR +M Y EAVI E  R   V  M +      D K  ++ 
Sbjct: 320 AQVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFF 379

Query: 730 IPKGTFILLSLYXLHHGP-HWKDPXTFRPERFL 825
           +PKGT +   L  +   P  + +P  F P+ FL
Sbjct: 380 LPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFL 412


>J02906-1|AAA52156.1|  491|Homo sapiens CYP2F1 protein.
          Length = 491

 Score =  110 bits (265), Expect = 5e-24
 Identities = 74/257 (28%), Positives = 120/257 (46%), Gaps = 7/257 (2%)
 Frame = +1

Query: 76  GEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGILNFLPF 255
           GEP     +   ++ NI+  ++ G R+D +D+RL  +  L+   F+++    G L     
Sbjct: 162 GEPFDPTFVLSRSVSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGEL--YDI 219

Query: 256 LRHFVPRLIGFTELQEIHNALHQY---LREIIKEHQENLQLGAPKDVIDAFLIDMLESQD 426
           L    P L+ +  +   H  + Q    LR++I     + Q  +P+D I  FL  M E ++
Sbjct: 220 LDPRFPSLLDW--VPGPHQRIFQNFKCLRDLIAHSVHDHQASSPRDFIQCFLTKMAEEKE 277

Query: 427 DKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRN 597
           D                    G +TV+ T     L +++   VQ ++ +EID ++GR R 
Sbjct: 278 DPLSHFHMDTLLMTTHNLLFGGTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARL 337

Query: 598 HLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHH 777
             L DR  M YT+AVI E  R + +  M +PH    D     ++IPKGT ++  L  +H+
Sbjct: 338 PALKDRAAMPYTDAVIHEVQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHY 397

Query: 778 GP-HWKDPXTFRPERFL 825
            P  +  P  F PE FL
Sbjct: 398 DPSQFLTPQEFNPEHFL 414


>U22027-1|AAB40518.1|  494|Homo sapiens cytochrome P450 protein.
          Length = 494

 Score =  109 bits (263), Expect = 9e-24
 Identities = 76/273 (27%), Positives = 128/273 (46%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE   L++   +  G  I        T+ N++  +V G R+D +D+    L  +++ +
Sbjct: 149 IQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGI 208

Query: 208 FKLVDMSGGILN--FLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAP 378
           F+    S G L   F   ++H   P+   F  LQ     L  ++ + ++ +Q  L   +P
Sbjct: 209 FQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQ----GLEDFIAKKVEHNQRTLDPNSP 264

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D ID+FLI M E + +                   AG ETV+ T  +  L ++++ +V+
Sbjct: 265 RDFIDSFLIRMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLHYGFLLLMKHPEVE 324

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
            K+H+EID +IG++R    +DR +M Y EAVI E  R   V  M +      D K  ++ 
Sbjct: 325 AKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFF 384

Query: 730 IPKGTFILLSL-YXLHHGPHWKDPXTFRPERFL 825
           +PKG  +   L   L     + +P  F P+ FL
Sbjct: 385 LPKGIEVFPMLGSVLRDLRFFSNPRDFNPQHFL 417


>AY871801-1|AAX62803.1|  483|Homo sapiens cytochrome P450 family 1
           subfamily A polypeptide 1 protein.
          Length = 483

 Score =  103 bits (247), Expect(2) = 1e-23
 Identities = 69/238 (28%), Positives = 114/238 (47%), Gaps = 8/238 (3%)
 Frame = +1

Query: 13  FMNVYIGEECEALVQLRLADAGEPILVNQMFHI--TIVNILWRLVAGKRYDLEDQRLKKL 186
           ++  ++ +E E L+         P   N   ++  ++ N++  +  G+RYD   Q L  L
Sbjct: 158 YLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSL 217

Query: 187 CSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIGFTELQEIHNALHQYLREIIKEHQENL 363
            +L     ++V  SG   +F+P LR+   P L  F +L E     + ++++++KEH +  
Sbjct: 218 VNLNNNFGEVVG-SGNPADFIPILRYLPNPSLNAFKDLNE---KFYSFMQKMVKEHYKTF 273

Query: 364 QLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE-----AGMETVTNTAVFMLLHV 528
           + G  +D+ D+ +    E Q D+                    AG +TVT    + L+++
Sbjct: 274 EKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYL 333

Query: 529 VRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMAL 702
           V N  VQRK+ +E+D +IGR R   L DR    Y EA ILET R S+     IPH  L
Sbjct: 334 VMNPRVQRKIQEELDTVIGRSRRPRLSDRSHPPYMEAFILETFRHSSFVPFTIPHKKL 391



 Score = 27.1 bits (57), Expect(2) = 1e-23
 Identities = 10/22 (45%), Positives = 13/22 (59%)
 Frame = +1

Query: 763 YXLHHGPHWKDPXTFRPERFLT 828
           + + H   W +P  F PERFLT
Sbjct: 384 FTIPHKKLWVNPSEFLPERFLT 405


>U37143-1|AAC50370.2|  502|Homo sapiens cytochrome P450
           monooxygenase CYP2J2 protein.
          Length = 502

 Score =  108 bits (260), Expect = 2e-23
 Identities = 72/271 (26%), Positives = 124/271 (45%), Gaps = 5/271 (1%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE + L +    + G+P   +   +  + NI+  +  G+R++ +D   ++L  L+  +
Sbjct: 159 IQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEV 218

Query: 208 FKL-VDMSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKD 384
             L    +  + N  P++  F+P       L      L  ++  +I +H+++      +D
Sbjct: 219 TYLEASKTCQLYNVFPWIMKFLPG--PHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRD 276

Query: 385 VIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQRK 555
            IDA+L +M +   +               +   AG ET + T  + LL++    ++Q K
Sbjct: 277 FIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEK 336

Query: 556 LHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIP 735
           +  EID +IG+ +      R  M YT AVI E  R+  +  + +P     D  L  Y +P
Sbjct: 337 VQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLP 396

Query: 736 KGTFILLSLYXLHHGP-HWKDPXTFRPERFL 825
           KGT IL +L  LH  P  W  P TF P+ FL
Sbjct: 397 KGTMILTNLTALHRDPTEWATPDTFNPDHFL 427


>BC032594-1|AAH32594.1|  502|Homo sapiens cytochrome P450, family 2,
           subfamily J, polypeptide 2 protein.
          Length = 502

 Score =  108 bits (260), Expect = 2e-23
 Identities = 72/271 (26%), Positives = 124/271 (45%), Gaps = 5/271 (1%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE + L +    + G+P   +   +  + NI+  +  G+R++ +D   ++L  L+  +
Sbjct: 159 IQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEV 218

Query: 208 FKL-VDMSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKD 384
             L    +  + N  P++  F+P       L      L  ++  +I +H+++      +D
Sbjct: 219 TYLEASKTCQLYNVFPWIMKFLPG--PHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRD 276

Query: 385 VIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQRK 555
            IDA+L +M +   +               +   AG ET + T  + LL++    ++Q K
Sbjct: 277 FIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEK 336

Query: 556 LHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIP 735
           +  EID +IG+ +      R  M YT AVI E  R+  +  + +P     D  L  Y +P
Sbjct: 337 VQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLP 396

Query: 736 KGTFILLSLYXLHHGP-HWKDPXTFRPERFL 825
           KGT IL +L  LH  P  W  P TF P+ FL
Sbjct: 397 KGTMILTNLTALHRDPTEWATPDTFNPDHFL 427


>AY426985-1|AAQ93356.1|  502|Homo sapiens cytochrome P450, family 2,
           subfamily J, polypeptide 2 protein.
          Length = 502

 Score =  108 bits (260), Expect = 2e-23
 Identities = 72/271 (26%), Positives = 124/271 (45%), Gaps = 5/271 (1%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE + L +    + G+P   +   +  + NI+  +  G+R++ +D   ++L  L+  +
Sbjct: 159 IQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEV 218

Query: 208 FKL-VDMSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKD 384
             L    +  + N  P++  F+P       L      L  ++  +I +H+++      +D
Sbjct: 219 TYLEASKTCQLYNVFPWIMKFLPG--PHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRD 276

Query: 385 VIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQRK 555
            IDA+L +M +   +               +   AG ET + T  + LL++    ++Q K
Sbjct: 277 FIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEK 336

Query: 556 LHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIP 735
           +  EID +IG+ +      R  M YT AVI E  R+  +  + +P     D  L  Y +P
Sbjct: 337 VQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLP 396

Query: 736 KGTFILLSLYXLHHGP-HWKDPXTFRPERFL 825
           KGT IL +L  LH  P  W  P TF P+ FL
Sbjct: 397 KGTMILTNLTALHRDPTEWATPDTFNPDHFL 427


>AF272142-1|AAM44456.1|  502|Homo sapiens cytochrome P450 protein.
          Length = 502

 Score =  108 bits (260), Expect = 2e-23
 Identities = 72/271 (26%), Positives = 124/271 (45%), Gaps = 5/271 (1%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE + L +    + G+P   +   +  + NI+  +  G+R++ +D   ++L  L+  +
Sbjct: 159 IQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEV 218

Query: 208 FKL-VDMSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKD 384
             L    +  + N  P++  F+P       L      L  ++  +I +H+++      +D
Sbjct: 219 TYLEASKTCQLYNVFPWIMKFLPG--PHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRD 276

Query: 385 VIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQRK 555
            IDA+L +M +   +               +   AG ET + T  + LL++    ++Q K
Sbjct: 277 FIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEK 336

Query: 556 LHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIP 735
           +  EID +IG+ +      R  M YT AVI E  R+  +  + +P     D  L  Y +P
Sbjct: 337 VQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLP 396

Query: 736 KGTFILLSLYXLHHGP-HWKDPXTFRPERFL 825
           KGT IL +L  LH  P  W  P TF P+ FL
Sbjct: 397 KGTMILTNLTALHRDPTEWATPDTFNPDHFL 427


>AB080265-1|BAB85489.1|  502|Homo sapiens cytochrome P450 2J2
           protein.
          Length = 502

 Score =  108 bits (259), Expect = 3e-23
 Identities = 72/271 (26%), Positives = 124/271 (45%), Gaps = 5/271 (1%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I EE + L +    + G+P   +   +  + NI+  +  G+R++ +D   ++L  L+  +
Sbjct: 159 IQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEV 218

Query: 208 FKL-VDMSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKD 384
             L    +  + N  P++  F+P       L      L  ++  +I +H+++      +D
Sbjct: 219 TYLEASKTCQLYNVFPWIMKFLPG--PHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRD 276

Query: 385 VIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQRK 555
            IDA+L +M +   +               +   AG ET + T  + LL++    ++Q K
Sbjct: 277 FIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEK 336

Query: 556 LHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIP 735
           +  EID +IG+ +      R  M YT AVI E  R+  +  + +P     D  L  Y +P
Sbjct: 337 VQVEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLP 396

Query: 736 KGTFILLSLYXLHHGP-HWKDPXTFRPERFL 825
           KGT IL +L  LH  P  W  P TF P+ FL
Sbjct: 397 KGTMILTNLTALHRDPTEWATPDTFNPDHFL 427


>AM236047-1|CAJ84704.1|  251|Homo sapiens cytochrome P450 1A1
           protein.
          Length = 251

 Score =  107 bits (258), Expect = 4e-23
 Identities = 58/173 (33%), Positives = 89/173 (51%), Gaps = 6/173 (3%)
 Frame = +1

Query: 328 LREIIKEHQENLQLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE-----AGMET 492
           +++++KEH +  + G  +D+ D+ +    E Q D+                    AG +T
Sbjct: 1   MQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDT 60

Query: 493 VTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTV 672
           VT    + L+++V N  VQRK+ +E+D +IGR R   L DR  + Y EA ILET R S+ 
Sbjct: 61  VTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSF 120

Query: 673 ASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGPH-WKDPXTFRPERFLT 828
               IPH    D  L  + IPKG  + ++ + ++H    W +P  F PERFLT
Sbjct: 121 VPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLT 173


>AM233517-1|CAJ80720.1|  175|Homo sapiens cytochrome P450 1A1
           protein.
          Length = 175

 Score =  107 bits (258), Expect = 4e-23
 Identities = 58/173 (33%), Positives = 89/173 (51%), Gaps = 6/173 (3%)
 Frame = +1

Query: 328 LREIIKEHQENLQLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE-----AGMET 492
           +++++KEH +  + G  +D+ D+ +    E Q D+                    AG +T
Sbjct: 1   MQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDT 60

Query: 493 VTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTV 672
           VT    + L+++V N  VQRK+ +E+D +IGR R   L DR  + Y EA ILET R S+ 
Sbjct: 61  VTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSF 120

Query: 673 ASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGPH-WKDPXTFRPERFLT 828
               IPH    D  L  + IPKG  + ++ + ++H    W +P  F PERFLT
Sbjct: 121 VPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLT 173


>M12078-1|AAA52154.1|  192|Homo sapiens POR protein.
          Length = 192

 Score =  105 bits (252), Expect = 2e-22
 Identities = 49/118 (41%), Positives = 72/118 (61%), Gaps = 1/118 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           AG +TVT    + L+++V   ++QRK+ +E+D +IGR+R   L DR ++ Y EA ILET 
Sbjct: 23  AGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETF 82

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGPH-WKDPXTFRPERFLT 828
           R S+     IPH    D  L  + IPK   + ++ + ++H P  W+DP  FRPERFLT
Sbjct: 83  RHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 140


>U56438-1|AAC50809.1|  543|Homo sapiens dioxin-inducible cytochrome
           P450 protein.
          Length = 543

 Score =  103 bits (246), Expect = 1e-21
 Identities = 63/249 (25%), Positives = 123/249 (49%), Gaps = 10/249 (4%)
 Frame = +1

Query: 109 ITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIG 285
           + + N++  +  G RY  +D   ++L S      + V  +G +++ +P+L++F  P    
Sbjct: 199 VAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVG-AGSLVDVMPWLQYFPNPVRTV 257

Query: 286 FTELQEIHNALHQYLREIIKEHQENLQLGA-PKDVIDAFLIDM-LESQDD------KXXX 441
           F E ++++     ++ +    H E+L+ GA P+D++DAF++    ++  D      +   
Sbjct: 258 FREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDL 317

Query: 442 XXXXXXXXXXXEAGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIR 621
                       A  +T++    ++LL   R  DVQ ++  E+D ++GRDR   + D+  
Sbjct: 318 ENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPN 377

Query: 622 MVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDP 798
           + Y  A + E +R S+   + IPH    +  +  Y IPK T + ++ + ++H P  W +P
Sbjct: 378 LPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNP 437

Query: 799 XTFRPERFL 825
             F P RFL
Sbjct: 438 ENFDPARFL 446


>U03688-1|AAA19567.1|  543|Homo sapiens cytochrome P450 protein.
          Length = 543

 Score =  103 bits (246), Expect = 1e-21
 Identities = 63/249 (25%), Positives = 123/249 (49%), Gaps = 10/249 (4%)
 Frame = +1

Query: 109 ITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIG 285
           + + N++  +  G RY  +D   ++L S      + V  +G +++ +P+L++F  P    
Sbjct: 199 VAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVG-AGSLVDVMPWLQYFPNPVRTV 257

Query: 286 FTELQEIHNALHQYLREIIKEHQENLQLGA-PKDVIDAFLIDM-LESQDD------KXXX 441
           F E ++++     ++ +    H E+L+ GA P+D++DAF++    ++  D      +   
Sbjct: 258 FREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDL 317

Query: 442 XXXXXXXXXXXEAGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIR 621
                       A  +T++    ++LL   R  DVQ ++  E+D ++GRDR   + D+  
Sbjct: 318 ENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPN 377

Query: 622 MVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDP 798
           + Y  A + E +R S+   + IPH    +  +  Y IPK T + ++ + ++H P  W +P
Sbjct: 378 LPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPVKWPNP 437

Query: 799 XTFRPERFL 825
             F P RFL
Sbjct: 438 ENFDPARFL 446


>BT019979-1|AAV38782.1|  543|Homo sapiens cytochrome P450, family 1,
           subfamily B, polypeptide 1 protein.
          Length = 543

 Score =  103 bits (246), Expect = 1e-21
 Identities = 63/249 (25%), Positives = 123/249 (49%), Gaps = 10/249 (4%)
 Frame = +1

Query: 109 ITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIG 285
           + + N++  +  G RY  +D   ++L S      + V  +G +++ +P+L++F  P    
Sbjct: 199 VAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVG-AGSLVDVMPWLQYFPNPVRTV 257

Query: 286 FTELQEIHNALHQYLREIIKEHQENLQLGA-PKDVIDAFLIDM-LESQDD------KXXX 441
           F E ++++     ++ +    H E+L+ GA P+D++DAF++    ++  D      +   
Sbjct: 258 FREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDL 317

Query: 442 XXXXXXXXXXXEAGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIR 621
                       A  +T++    ++LL   R  DVQ ++  E+D ++GRDR   + D+  
Sbjct: 318 ENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPN 377

Query: 622 MVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDP 798
           + Y  A + E +R S+   + IPH    +  +  Y IPK T + ++ + ++H P  W +P
Sbjct: 378 LPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNP 437

Query: 799 XTFRPERFL 825
             F P RFL
Sbjct: 438 ENFDPARFL 446


>BC012049-1|AAH12049.1|  543|Homo sapiens cytochrome P450, family 1,
           subfamily B, polypeptide 1 protein.
          Length = 543

 Score =  103 bits (246), Expect = 1e-21
 Identities = 63/249 (25%), Positives = 123/249 (49%), Gaps = 10/249 (4%)
 Frame = +1

Query: 109 ITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIG 285
           + + N++  +  G RY  +D   ++L S      + V  +G +++ +P+L++F  P    
Sbjct: 199 VAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVG-AGSLVDVMPWLQYFPNPVRTV 257

Query: 286 FTELQEIHNALHQYLREIIKEHQENLQLGA-PKDVIDAFLIDM-LESQDD------KXXX 441
           F E ++++     ++ +    H E+L+ GA P+D++DAF++    ++  D      +   
Sbjct: 258 FREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDL 317

Query: 442 XXXXXXXXXXXEAGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIR 621
                       A  +T++    ++LL   R  DVQ ++  E+D ++GRDR   + D+  
Sbjct: 318 ENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPN 377

Query: 622 MVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDP 798
           + Y  A + E +R S+   + IPH    +  +  Y IPK T + ++ + ++H P  W +P
Sbjct: 378 LPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPVKWPNP 437

Query: 799 XTFRPERFL 825
             F P RFL
Sbjct: 438 ENFDPARFL 446


>AY393998-1|AAQ87875.1|  543|Homo sapiens cytochrome P450, family 1,
           subfamily B, polypeptide 1 protein.
          Length = 543

 Score =  103 bits (246), Expect = 1e-21
 Identities = 63/249 (25%), Positives = 123/249 (49%), Gaps = 10/249 (4%)
 Frame = +1

Query: 109 ITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIG 285
           + + N++  +  G RY  +D   ++L S      + V  +G +++ +P+L++F  P    
Sbjct: 199 VAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVG-AGSLVDVMPWLQYFPNPVRTV 257

Query: 286 FTELQEIHNALHQYLREIIKEHQENLQLGA-PKDVIDAFLIDM-LESQDD------KXXX 441
           F E ++++     ++ +    H E+L+ GA P+D++DAF++    ++  D      +   
Sbjct: 258 FREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDL 317

Query: 442 XXXXXXXXXXXEAGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIR 621
                       A  +T++    ++LL   R  DVQ ++  E+D ++GRDR   + D+  
Sbjct: 318 ENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPN 377

Query: 622 MVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDP 798
           + Y  A + E +R S+   + IPH    +  +  Y IPK T + ++ + ++H P  W +P
Sbjct: 378 LPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNP 437

Query: 799 XTFRPERFL 825
             F P RFL
Sbjct: 438 ENFDPARFL 446


>AF450132-1|AAM50512.1|  543|Homo sapiens cytochrome P450 CYP1B1
           protein.
          Length = 543

 Score =  103 bits (246), Expect = 1e-21
 Identities = 63/249 (25%), Positives = 123/249 (49%), Gaps = 10/249 (4%)
 Frame = +1

Query: 109 ITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIG 285
           + + N++  +  G RY  +D   ++L S      + V  +G +++ +P+L++F  P    
Sbjct: 199 VAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVG-AGSLVDVMPWLQYFPNPVRTV 257

Query: 286 FTELQEIHNALHQYLREIIKEHQENLQLGA-PKDVIDAFLIDM-LESQDD------KXXX 441
           F E ++++     ++ +    H E+L+ GA P+D++DAF++    ++  D      +   
Sbjct: 258 FREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDL 317

Query: 442 XXXXXXXXXXXEAGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIR 621
                       A  +T++    ++LL   R  DVQ ++  E+D ++GRDR   + D+  
Sbjct: 318 ENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPN 377

Query: 622 MVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDP 798
           + Y  A + E +R S+   + IPH    +  +  Y IPK T + ++ + ++H P  W +P
Sbjct: 378 LPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNP 437

Query: 799 XTFRPERFL 825
             F P RFL
Sbjct: 438 ENFDPARFL 446


>AC009229-2|AAY15039.1|  543|Homo sapiens unknown protein.
          Length = 543

 Score =  103 bits (246), Expect = 1e-21
 Identities = 63/249 (25%), Positives = 123/249 (49%), Gaps = 10/249 (4%)
 Frame = +1

Query: 109 ITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIG 285
           + + N++  +  G RY  +D   ++L S      + V  +G +++ +P+L++F  P    
Sbjct: 199 VAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVG-AGSLVDVMPWLQYFPNPVRTV 257

Query: 286 FTELQEIHNALHQYLREIIKEHQENLQLGA-PKDVIDAFLIDM-LESQDD------KXXX 441
           F E ++++     ++ +    H E+L+ GA P+D++DAF++    ++  D      +   
Sbjct: 258 FREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDL 317

Query: 442 XXXXXXXXXXXEAGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIR 621
                       A  +T++    ++LL   R  DVQ ++  E+D ++GRDR   + D+  
Sbjct: 318 ENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPN 377

Query: 622 MVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDP 798
           + Y  A + E +R S+   + IPH    +  +  Y IPK T + ++ + ++H P  W +P
Sbjct: 378 LPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPVKWPNP 437

Query: 799 XTFRPERFL 825
             F P RFL
Sbjct: 438 ENFDPARFL 446


>M29873-1|AAA52143.1|  377|Homo sapiens CYP2B protein.
          Length = 377

 Score =  102 bits (244), Expect = 2e-21
 Identities = 68/230 (29%), Positives = 117/230 (50%), Gaps = 7/230 (3%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I +E + L++      G  +    +FH    NI+  ++ GKR+  +DQ   K  +L  + 
Sbjct: 146 IQDEAQCLIEELRKSKGALVDPTFLFHSITANIICSIIFGKRFHYQDQEFLKTLNLFCQS 205

Query: 208 FKLVD-MSGGILN-FLPFLRHF--VPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
           F L+  +S  +   F  FL++F    R + +  LQEI NA   Y+   +++H+E L   A
Sbjct: 206 FLLISSISSQLFELFSGFLKYFPGAHRQV-YKNLQEI-NA---YIGHSVEKHRETLDPSA 260

Query: 376 PKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDV 546
           P+D+ID +L+ M + + +                   AG ET + T  +  L +++   V
Sbjct: 261 PRDLIDTYLLHMEKEKSNPHSEFSHQNLIINTLSLFFAGTETTSTTLRYGFLLMLKYPHV 320

Query: 547 QRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHM 696
             ++++EI+ ++G  R   LDDR +M YTEAVI E  R + +  MG+PH+
Sbjct: 321 AERVYKEIEQVVGPHRPPALDDRAKMPYTEAVIREIQRFADLLPMGVPHI 370


>BT020001-1|AAV38804.1|  543|Homo sapiens cytochrome P450, family 1,
           subfamily B, polypeptide 1 protein.
          Length = 543

 Score =  102 bits (244), Expect = 2e-21
 Identities = 63/249 (25%), Positives = 123/249 (49%), Gaps = 10/249 (4%)
 Frame = +1

Query: 109 ITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGILNFLPFLRHFV-PRLIG 285
           + + N++  +  G RY  +D   ++L S      + V  +G +++ +P+L++F  P    
Sbjct: 199 VAMANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVG-AGSLVDVMPWLQYFPNPVRTV 257

Query: 286 FTELQEIHNALHQYLREIIKEHQENLQLGA-PKDVIDAFLIDM-LESQDD------KXXX 441
           F E ++++     ++ +    H E+L+ GA P+D++DAF++    ++  D      +   
Sbjct: 258 FREFEQLNRNFSSFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDL 317

Query: 442 XXXXXXXXXXXEAGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIR 621
                       A  +T++    ++LL   R  DVQ ++  E+D ++GRDR   + D+  
Sbjct: 318 ENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPN 377

Query: 622 MVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDP 798
           + Y  A + E +R S+   + IPH    +  +  Y IPK T + ++ + ++H P  W +P
Sbjct: 378 LPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPVKWPNP 437

Query: 799 XTFRPERFL 825
             F P RFL
Sbjct: 438 ENFDPARFL 446


>BC041174-1|AAH41174.1|  377|Homo sapiens CYP2B7P1 protein protein.
          Length = 377

 Score =  102 bits (244), Expect = 2e-21
 Identities = 68/230 (29%), Positives = 117/230 (50%), Gaps = 7/230 (3%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I +E + L++      G  +    +FH    NI+  ++ GKR+  +DQ   K  +L  + 
Sbjct: 146 IQDEAQCLIEELRKSKGALVDPTFLFHSITANIICSIIFGKRFHYQDQEFLKTLNLFCQS 205

Query: 208 FKLVD-MSGGILN-FLPFLRHF--VPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
           F L+  +S  +   F  FL++F    R + +  LQEI NA   Y+   +++H+E L   A
Sbjct: 206 FLLISSISSQLFELFSGFLKYFPGAHRQV-YKNLQEI-NA---YIGHSVEKHRETLDPSA 260

Query: 376 PKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDV 546
           P+D+ID +L+ M + + +                   AG ET + T  +  L +++   V
Sbjct: 261 PRDLIDTYLLHMEKEKSNPHSEFSHQNLIINTLSLFFAGTETTSTTLRYGFLLMLKYPHV 320

Query: 547 QRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHM 696
             ++++EI+ ++G  R   LDDR +M YTEAVI E  R + +  MG+PH+
Sbjct: 321 AERVYKEIEQVVGPHRPPALDDRAKMPYTEAVIREIQRFADLLPMGVPHI 370


>AY220845-1|AAO49806.1|  516|Homo sapiens cytochrome P450 protein.
          Length = 516

 Score =  101 bits (242), Expect = 3e-21
 Identities = 82/294 (27%), Positives = 129/294 (43%), Gaps = 27/294 (9%)
 Frame = +1

Query: 25   YIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMR 204
            ++ EE   L       AG P   N +    + N++  L  G+R++ +D R  +L  L   
Sbjct: 152  WVTEEAACLCAAFADQAGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE 211

Query: 205  LFKLVDMSG---GILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGA 375
              K  + SG    +LN +P L H +P L G  ++     A    L E++ EH+       
Sbjct: 212  GLK--EESGFLREVLNAVPVLPH-IPALAG--KVLRFQKAFLTQLDELLTEHRMTWDPAQ 266

Query: 376  P-KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNED 543
            P +D+ +AFL    +++                     AGM T   T  + LL ++ + D
Sbjct: 267  PPRDLTEAFLAKKEKAKGSPESSFNDENLRIVVGNLFLAGMVTTLTTLAWGLLLMILHLD 326

Query: 544  VQR-------------------KLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRIS 666
            VQR                   ++ QEIDD+IG+ R   + D++ M YT AVI E  R  
Sbjct: 327  VQRGRRVSPGCSPIVGTHVCPVRVQQEIDDVIGQVRRPEMGDQVHMPYTTAVIHEVQRFG 386

Query: 667  TVASMGIPHMALNDAKLGNYIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
             +  +G+ HM   D ++  + IPKGT ++ +L   L     W+ P  F PE FL
Sbjct: 387  DIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 440


>M63871-1|AAA59984.1|  508|Homo sapiens CYP17 protein.
          Length = 508

 Score =  100 bits (240), Expect = 6e-21
 Identities = 48/117 (41%), Positives = 71/117 (60%), Gaps = 1/117 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           AG+ET T+   + L  ++ N  V++KL++EID  +G  R   + DR R++  EA I E L
Sbjct: 302 AGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVL 361

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHG-PHWKDPXTFRPERFL 825
           R+  VA M IPH A  D+ +G + + KGT ++++L+ LHH    W  P  F PERFL
Sbjct: 362 RLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFL 418


>M31153-1|AAA52140.1|  508|Homo sapiens CYP17 protein.
          Length = 508

 Score =  100 bits (240), Expect = 6e-21
 Identities = 48/117 (41%), Positives = 71/117 (60%), Gaps = 1/117 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           AG+ET T+   + L  ++ N  V++KL++EID  +G  R   + DR R++  EA I E L
Sbjct: 302 AGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVL 361

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHG-PHWKDPXTFRPERFL 825
           R+  VA M IPH A  D+ +G + + KGT ++++L+ LHH    W  P  F PERFL
Sbjct: 362 RLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFL 418


>M19489-1|AAA36405.1|  508|Homo sapiens CYP17 protein.
          Length = 508

 Score =  100 bits (240), Expect = 6e-21
 Identities = 48/117 (41%), Positives = 71/117 (60%), Gaps = 1/117 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           AG+ET T+   + L  ++ N  V++KL++EID  +G  R   + DR R++  EA I E L
Sbjct: 302 AGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVL 361

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHG-PHWKDPXTFRPERFL 825
           R+  VA M IPH A  D+ +G + + KGT ++++L+ LHH    W  P  F PERFL
Sbjct: 362 RLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFL 418


>M14564-1|AAA52151.1|  508|Homo sapiens CYP17 protein.
          Length = 508

 Score =  100 bits (240), Expect = 6e-21
 Identities = 48/117 (41%), Positives = 71/117 (60%), Gaps = 1/117 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           AG+ET T+   + L  ++ N  V++KL++EID  +G  R   + DR R++  EA I E L
Sbjct: 302 AGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVL 361

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHG-PHWKDPXTFRPERFL 825
           R+  VA M IPH A  D+ +G + + KGT ++++L+ LHH    W  P  F PERFL
Sbjct: 362 RLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFL 418


>DQ530598-1|ABF50972.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score =  100 bits (240), Expect = 6e-21
 Identities = 48/117 (41%), Positives = 71/117 (60%), Gaps = 1/117 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           AG+ET T+   + L  ++ N  V++KL++EID  +G  R   + DR R++  EA I E L
Sbjct: 302 AGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVL 361

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHG-PHWKDPXTFRPERFL 825
           R+  VA M IPH A  D+ +G + + KGT ++++L+ LHH    W  P  F PERFL
Sbjct: 362 RLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFL 418


>BT020000-1|AAV38803.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score =  100 bits (240), Expect = 6e-21
 Identities = 48/117 (41%), Positives = 71/117 (60%), Gaps = 1/117 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           AG+ET T+   + L  ++ N  V++KL++EID  +G  R   + DR R++  EA I E L
Sbjct: 302 AGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVL 361

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHG-PHWKDPXTFRPERFL 825
           R+  VA M IPH A  D+ +G + + KGT ++++L+ LHH    W  P  F PERFL
Sbjct: 362 RLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFL 418


>BC063388-1|AAH63388.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score =  100 bits (240), Expect = 6e-21
 Identities = 48/117 (41%), Positives = 71/117 (60%), Gaps = 1/117 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           AG+ET T+   + L  ++ N  V++KL++EID  +G  R   + DR R++  EA I E L
Sbjct: 302 AGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVL 361

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHG-PHWKDPXTFRPERFL 825
           R+  VA M IPH A  D+ +G + + KGT ++++L+ LHH    W  P  F PERFL
Sbjct: 362 RLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFL 418


>BC062997-1|AAH62997.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score =  100 bits (240), Expect = 6e-21
 Identities = 48/117 (41%), Positives = 71/117 (60%), Gaps = 1/117 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           AG+ET T+   + L  ++ N  V++KL++EID  +G  R   + DR R++  EA I E L
Sbjct: 302 AGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVL 361

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHG-PHWKDPXTFRPERFL 825
           R+  VA M IPH A  D+ +G + + KGT ++++L+ LHH    W  P  F PERFL
Sbjct: 362 RLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFL 418


>AL358790-3|CAI52498.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score =  100 bits (240), Expect = 6e-21
 Identities = 48/117 (41%), Positives = 71/117 (60%), Gaps = 1/117 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           AG+ET T+   + L  ++ N  V++KL++EID  +G  R   + DR R++  EA I E L
Sbjct: 302 AGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVL 361

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHG-PHWKDPXTFRPERFL 825
           R+  VA M IPH A  D+ +G + + KGT ++++L+ LHH    W  P  F PERFL
Sbjct: 362 RLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFL 418


>M12079-1|AAA52152.1|  191|Homo sapiens POR protein.
          Length = 191

 Score =  100 bits (239), Expect = 7e-21
 Identities = 49/118 (41%), Positives = 68/118 (57%), Gaps = 1/118 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           AG +TVT    + L+++V N  VQRK+ +E+D +IGR R   L DR  + Y EA ILET 
Sbjct: 23  AGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETF 82

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGPH-WKDPXTFRPERFLT 828
           R S+     IPH    D  L  + IPKG  + ++ + ++H    W +P  F PERFLT
Sbjct: 83  RHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLT 140


>EF122244-1|ABO41979.1|  216|Homo sapiens cytochrome P450 2F1
           variant protein.
          Length = 216

 Score = 97.9 bits (233), Expect = 4e-20
 Identities = 54/174 (31%), Positives = 83/174 (47%), Gaps = 4/174 (2%)
 Frame = +1

Query: 316 LHQYLREIIKEHQENLQLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGM 486
           L   +   + +HQ +L   +P+D I  FL  M E ++D                    G 
Sbjct: 26  LRDLIAHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGT 85

Query: 487 ETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRIS 666
           +TV+ T     L +++   VQ ++ +EID ++GR R   L DR  M YT+AVI E  R +
Sbjct: 86  KTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFA 145

Query: 667 TVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDPXTFRPERFL 825
            +  M +PH    D     ++IPKGT ++  L  +H+ P  +  P  F PE FL
Sbjct: 146 DIIPMNLPHRVTRDTAFRGFLIPKGTDVITPLNTVHYDPSQFLTPQEFNPEHFL 199


>BC033691-1|AAH33691.1|  504|Homo sapiens cytochrome P450, family 2,
           subfamily S, polypeptide 1 protein.
          Length = 504

 Score = 94.7 bits (225), Expect = 4e-19
 Identities = 71/273 (26%), Positives = 121/273 (44%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I  E   LV+      G P   + +      N++  L+ G R+  ED+  + +       
Sbjct: 149 IQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGT 208

Query: 208 FKLVDMSGGILNFLPFLRHFVPRLIGFTELQEIHNA--LHQYLREIIKEHQENLQLGAP- 378
              V   GG          F+  L G    Q +H+   L  +    +++HQ NL    P 
Sbjct: 209 LLGVSSQGG--QTYEMFSWFLRPLPG-PHKQLLHHVSTLAAFTVRQVQQHQGNLDASGPA 265

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D++DAFL+ M + + +                   AG  TV+ T  + LL +++   VQ
Sbjct: 266 RDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQ 325

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
           + + +E++  +G  +   L DR R+ YT+AV+ E  R+  +  MGIP   +   +   Y 
Sbjct: 326 KWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYT 385

Query: 730 IPKGTFILLSLYXLHHGPH-WKDPXTFRPERFL 825
           +P+GT +   L  + H P+ +K P  F P+RFL
Sbjct: 386 LPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFL 418


>AY358603-1|AAQ88966.1|  504|Homo sapiens Cytochrome p450 protein.
          Length = 504

 Score = 94.7 bits (225), Expect = 4e-19
 Identities = 71/273 (26%), Positives = 121/273 (44%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I  E   LV+      G P   + +      N++  L+ G R+  ED+  + +       
Sbjct: 149 IQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGT 208

Query: 208 FKLVDMSGGILNFLPFLRHFVPRLIGFTELQEIHNA--LHQYLREIIKEHQENLQLGAP- 378
              V   GG          F+  L G    Q +H+   L  +    +++HQ NL    P 
Sbjct: 209 LLGVSSQGG--QTYEMFSWFLRPLPG-PHKQLLHHVSTLAAFTVRQVQQHQGNLDASGPA 265

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D++DAFL+ M + + +                   AG  TV+ T  + LL +++   VQ
Sbjct: 266 RDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQ 325

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
           + + +E++  +G  +   L DR R+ YT+AV+ E  R+  +  MGIP   +   +   Y 
Sbjct: 326 KWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYT 385

Query: 730 IPKGTFILLSLYXLHHGPH-WKDPXTFRPERFL 825
           +P+GT +   L  + H P+ +K P  F P+RFL
Sbjct: 386 LPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFL 418


>AK027605-1|BAB55227.1|  564|Homo sapiens protein ( Homo sapiens
           cDNA FLJ14699 fis, clone NT2RP2006571, moderately
           similar to CYTOCHROME P450 2G1 (EC 1.14.14.1). ).
          Length = 564

 Score = 94.7 bits (225), Expect = 4e-19
 Identities = 71/273 (26%), Positives = 121/273 (44%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I  E   LV+      G P   + +      N++  L+ G R+  ED+  + +       
Sbjct: 149 IQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGT 208

Query: 208 FKLVDMSGGILNFLPFLRHFVPRLIGFTELQEIHNA--LHQYLREIIKEHQENLQLGAP- 378
              V   GG          F+  L G    Q +H+   L  +    +++HQ NL    P 
Sbjct: 209 LLGVSSQGG--QTYEMFSWFLRPLPG-PHKQLLHHVSTLAAFTVRQVQQHQGNLDASGPA 265

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D++DAFL+ M + + +                   AG  TV+ T  + LL +++   VQ
Sbjct: 266 RDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQ 325

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
           + + +E++  +G  +   L DR R+ YT+AV+ E  R+  +  MGIP   +   +   Y 
Sbjct: 326 KWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYT 385

Query: 730 IPKGTFILLSLYXLHHGPH-WKDPXTFRPERFL 825
           +P+GT +   L  + H P+ +K P  F P+RFL
Sbjct: 386 LPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFL 418


>AF335278-1|AAK13498.1|  504|Homo sapiens cytochrome P450 2S1
           protein.
          Length = 504

 Score = 94.7 bits (225), Expect = 4e-19
 Identities = 71/273 (26%), Positives = 121/273 (44%), Gaps = 7/273 (2%)
 Frame = +1

Query: 28  IGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           I  E   LV+      G P   + +      N++  L+ G R+  ED+  + +       
Sbjct: 149 IQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGT 208

Query: 208 FKLVDMSGGILNFLPFLRHFVPRLIGFTELQEIHNA--LHQYLREIIKEHQENLQLGAP- 378
              V   GG          F+  L G    Q +H+   L  +    +++HQ NL    P 
Sbjct: 209 LLGVSSQGG--QTYEMFSWFLRPLPG-PHKQLLHHVSTLAAFTVRQVQQHQGNLDASGPA 265

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE---AGMETVTNTAVFMLLHVVRNEDVQ 549
           +D++DAFL+ M + + +                   AG  TV+ T  + LL +++   VQ
Sbjct: 266 RDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQ 325

Query: 550 RKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYI 729
           + + +E++  +G  +   L DR R+ YT+AV+ E  R+  +  MGIP   +   +   Y 
Sbjct: 326 KWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYT 385

Query: 730 IPKGTFILLSLYXLHHGPH-WKDPXTFRPERFL 825
           +P+GT +   L  + H P+ +K P  F P+RFL
Sbjct: 386 LPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFL 418


>K03192-1|AAA52147.1|  331|Homo sapiens CYP1A1 protein.
          Length = 331

 Score = 94.3 bits (224), Expect = 5e-19
 Identities = 64/242 (26%), Positives = 114/242 (47%), Gaps = 5/242 (2%)
 Frame = +1

Query: 112 TIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKL-VDMSGGILNFLPFLRHFVPRLIGF 288
           T  N++  +V G R+D +D+ L  L  +++ +  + V+ +G +      +   +P     
Sbjct: 15  TFSNVISSIVFGDRFDYKDRELLSLFRIMLVIVPVHVNSTGQLYEMFSSVMKQLPG--PQ 72

Query: 289 TELQEIHNALHQYLREIIKEHQENLQLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXX 468
            +  ++   L  ++ + + EH   L   +P+D ID+FLI M E + +             
Sbjct: 73  QQAFQLLQGLEDFIAKKV-EHNTPLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLEKLVMT 131

Query: 469 XXE---AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEA 639
                  G ETV+ T  +  L ++++  V+ K+H+EID +IG++R    +DR +M Y EA
Sbjct: 132 SLNLFIGGTETVSTTLRYGFLLLIKHPGVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEA 191

Query: 640 VILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGPHW-KDPXTFRPE 816
           +I E  R   V  M  P     D K  ++ +PKGT +   L  +   P +   P  F P+
Sbjct: 192 MIHEIQRFGDVIPMIWPGRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPIFLSKPQDFNPQ 251

Query: 817 RF 822
            F
Sbjct: 252 HF 253


>AM233518-1|CAJ80721.1|  157|Homo sapiens cytochrome P450 1A1
           protein.
          Length = 157

 Score = 92.7 bits (220), Expect = 1e-18
 Identities = 49/155 (31%), Positives = 79/155 (50%), Gaps = 5/155 (3%)
 Frame = +1

Query: 328 LREIIKEHQENLQLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE-----AGMET 492
           +++++KEH +  + G  +D+ D+ +    E Q D+                    AG +T
Sbjct: 1   MQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDT 60

Query: 493 VTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTV 672
           VT    + L+++V N  VQRK+ +E+D +IGR R   L DR  + Y EA ILET R S+ 
Sbjct: 61  VTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSF 120

Query: 673 ASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHH 777
               IPH    D  L  + IPKG  + ++ + ++H
Sbjct: 121 VPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINH 155


>X51535-1|CAA35915.1|  210|Homo sapiens cytochrome P-450 HPH (120
           AA) protein.
          Length = 210

 Score = 91.9 bits (218), Expect = 3e-18
 Identities = 47/117 (40%), Positives = 67/117 (57%), Gaps = 1/117 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           AG ET + T  + LL ++++ +V  K+ +EID +IGR R+  + DR  M YT+AV+ E  
Sbjct: 17  AGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQ 76

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           R S +   G+PH    D K  NY+IPKGT I+  L   LH    + +P  F P  FL
Sbjct: 77  RYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDREFPNPNIFDPGHFL 133


>L39102-1|AAL31348.1|  217|Homo sapiens S-mephenytoin 4-hydroxylase
           protein.
          Length = 217

 Score = 89.0 bits (211), Expect = 2e-17
 Identities = 46/117 (39%), Positives = 67/117 (57%), Gaps = 1/117 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           AG ET + T  + LL ++++ +V  K+ +EI+ +IGR+R+  + DR  M YT+AV+ E  
Sbjct: 24  AGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQ 83

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           R   +    +PH    D K  NY+IPKGT IL SL   LH    + +P  F P  FL
Sbjct: 84  RYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFL 140


>AK223008-1|BAD96728.1|  502|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 5 variant protein.
          Length = 502

 Score = 86.6 bits (205), Expect = 1e-16
 Identities = 42/116 (36%), Positives = 66/116 (56%), Gaps = 1/116 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           AG ET ++   F L  +  + DVQ+KL +EID ++        D  ++M Y + V+ ETL
Sbjct: 305 AGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETL 364

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDPXTFRPERF 822
           R+  VA + +    + D ++    IPKG+ +++  Y LHH P +W +P  FRPERF
Sbjct: 365 RLFPVA-IRLERTCMKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF 419


>AF040259-1|AAD10199.1|  144|Homo sapiens cytochrome P450 1A1
           protein.
          Length = 144

 Score = 86.2 bits (204), Expect = 1e-16
 Identities = 42/108 (38%), Positives = 61/108 (56%), Gaps = 1/108 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           AG +TVT    + L+++V N  VQRK+ +E+D +IGR R   L DR  + Y EA ILET 
Sbjct: 36  AGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETF 95

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGPH-WKDP 798
           R S+     IPH    D  L  + IPKG  + ++ + ++H    W +P
Sbjct: 96  RHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNP 143


>D00408-1|BAA00310.1|  503|Homo sapiens cytochrome P-450 HFLa
           protein.
          Length = 503

 Score = 85.8 bits (203), Expect = 2e-16
 Identities = 61/262 (23%), Positives = 116/262 (44%), Gaps = 8/262 (3%)
 Frame = +1

Query: 61  RLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGIL 240
           R A+ G+P+ +  +F    ++++     G   D  +           +L +   +   +L
Sbjct: 162 REAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVL 221

Query: 241 NFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKDVIDAFLIDMLES 420
           +   F   F+  ++    +      +  +L + +K+ +E       K  +D FL  M++S
Sbjct: 222 SIKVF--PFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVD-FLQLMIDS 278

Query: 421 QDDKXXXXXXXXXXXXXXE-------AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDI 579
           Q+ K                      AG ET ++   F++  +  + DVQ+K+ +EID +
Sbjct: 279 QNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTV 338

Query: 580 IGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLS 759
           +        D  +++ Y + V+ ETLR+  VA M +  +   D ++    IPKG  +++ 
Sbjct: 339 LPNKAPPTYDTVLQLEYLDMVVNETLRLFPVA-MRLERVCKKDVEINGMFIPKGVVVMIP 397

Query: 760 LYXLHHGP-HWKDPXTFRPERF 822
            Y LHH P +W +P  F PERF
Sbjct: 398 SYVLHHDPKYWTEPEKFLPERF 419


>BC067436-1|AAH67436.1|  503|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 7 protein.
          Length = 503

 Score = 85.8 bits (203), Expect = 2e-16
 Identities = 61/262 (23%), Positives = 116/262 (44%), Gaps = 8/262 (3%)
 Frame = +1

Query: 61  RLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGIL 240
           R A+ G+P+ +  +F    ++++     G   D  +           +L +   +   +L
Sbjct: 162 REAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVL 221

Query: 241 NFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKDVIDAFLIDMLES 420
           +   F   F+  ++    +      +  +L + +K+ +E       K  +D FL  M++S
Sbjct: 222 SIKVF--PFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVD-FLQLMIDS 278

Query: 421 QDDKXXXXXXXXXXXXXXE-------AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDI 579
           Q+ K                      AG ET ++   F++  +  + DVQ+K+ +EID +
Sbjct: 279 QNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTV 338

Query: 580 IGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLS 759
           +        D  +++ Y + V+ ETLR+  VA M +  +   D ++    IPKG  +++ 
Sbjct: 339 LPNKAPPTYDTVLQLEYLDMVVNETLRLFPVA-MRLERVCKKDVEINGMFIPKGVVVMIP 397

Query: 760 LYXLHHGP-HWKDPXTFRPERF 822
            Y LHH P +W +P  F PERF
Sbjct: 398 SYVLHHDPKYWTEPEKFLPERF 419


>AF315325-1|AAG48618.1|  535|Homo sapiens cytochrome P450 variant
           3A7 protein.
          Length = 535

 Score = 85.8 bits (203), Expect = 2e-16
 Identities = 61/262 (23%), Positives = 116/262 (44%), Gaps = 8/262 (3%)
 Frame = +1

Query: 61  RLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGIL 240
           R A+ G+P+ +  +F    ++++     G   D  +           +L +   +   +L
Sbjct: 162 REAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVL 221

Query: 241 NFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKDVIDAFLIDMLES 420
           +   F   F+  ++    +      +  +L + +K+ +E       K  +D FL  M++S
Sbjct: 222 SIKVF--PFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVD-FLQLMIDS 278

Query: 421 QDDKXXXXXXXXXXXXXXE-------AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDI 579
           Q+ K                      AG ET ++   F++  +  + DVQ+K+ +EID +
Sbjct: 279 QNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTV 338

Query: 580 IGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLS 759
           +        D  +++ Y + V+ ETLR+  VA M +  +   D ++    IPKG  +++ 
Sbjct: 339 LPNKAPPTYDTVLQLEYLDMVVNETLRLFPVA-MRLERVCKKDVEINGMFIPKGVVVMIP 397

Query: 760 LYXLHHGP-HWKDPXTFRPERF 822
            Y LHH P +W +P  F PERF
Sbjct: 398 SYVLHHDPKYWTEPEKFLPERF 419


>AF280107-3|AAG32289.1|  503|Homo sapiens cytochrome P450
           polypeptide 7 protein.
          Length = 503

 Score = 85.8 bits (203), Expect = 2e-16
 Identities = 61/262 (23%), Positives = 116/262 (44%), Gaps = 8/262 (3%)
 Frame = +1

Query: 61  RLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGIL 240
           R A+ G+P+ +  +F    ++++     G   D  +           +L +   +   +L
Sbjct: 162 REAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVL 221

Query: 241 NFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKDVIDAFLIDMLES 420
           +   F   F+  ++    +      +  +L + +K+ +E       K  +D FL  M++S
Sbjct: 222 SIKVF--PFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVD-FLQLMIDS 278

Query: 421 QDDKXXXXXXXXXXXXXXE-------AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDI 579
           Q+ K                      AG ET ++   F++  +  + DVQ+K+ +EID +
Sbjct: 279 QNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTV 338

Query: 580 IGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLS 759
           +        D  +++ Y + V+ ETLR+  VA M +  +   D ++    IPKG  +++ 
Sbjct: 339 LPNKAPPTYDTVLQLEYLDMVVNETLRLFPVA-MRLERVCKKDVEINGMFIPKGVVVMIP 397

Query: 760 LYXLHHGP-HWKDPXTFRPERF 822
            Y LHH P +W +P  F PERF
Sbjct: 398 SYVLHHDPKYWTEPEKFLPERF 419


>M28548-1|AAA52065.1|  495|Homo sapiens protein ( Human mutant
           21-hydroxylase B gene, complete cds. ).
          Length = 495

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 65/281 (23%), Positives = 122/281 (43%), Gaps = 9/281 (3%)
 Frame = +1

Query: 10  DFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLC 189
           D M   + +  +   +   A  G P+ + + F +   +I+  L  G +   +D  +    
Sbjct: 134 DSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYY 192

Query: 190 SLVMRLFKLVD-MSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQ 366
             +  + K     S  I++ +PFLR F P   G   L++        +   +++H+E+L 
Sbjct: 193 KCIQEVLKTWSHWSIQIVDVIPFLRFF-PNP-GLRRLKQAIEKRDHIVEMQLRQHKESLV 250

Query: 367 LGAPKDVIDAFLIDM----LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVR 534
            G  +D++D  L  +    +E    +                G ET  NT  + ++ ++ 
Sbjct: 251 AGQWRDMMDYMLQGVAQPTMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLH 310

Query: 535 NEDVQRKLHQEIDDIIGRDRNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           + ++Q++L +E+D  +G   +       DR R+    A I E LR+  V  + +PH    
Sbjct: 311 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 370

Query: 706 DAKLGNYIIPKGTFILLSLYXLH-HGPHWKDPXTFRPERFL 825
            + +  Y IP+GT I+ +L   H     W+ P  F P+RFL
Sbjct: 371 PSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL 411


>M26856-1|AAA52064.1|  495|Homo sapiens protein ( Human
           21-hydroxylase B gene, complete cds. ).
          Length = 495

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 65/281 (23%), Positives = 122/281 (43%), Gaps = 9/281 (3%)
 Frame = +1

Query: 10  DFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLC 189
           D M   + +  +   +   A  G P+ + + F +   +I+  L  G +   +D  +    
Sbjct: 134 DSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYY 192

Query: 190 SLVMRLFKLVD-MSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQ 366
             +  + K     S  I++ +PFLR F P   G   L++        +   +++H+E+L 
Sbjct: 193 KCIQEVLKTWSHWSIQIVDVIPFLRFF-PNP-GLRRLKQAIEKRDHIVEMQLRQHKESLV 250

Query: 367 LGAPKDVIDAFLIDM----LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVR 534
            G  +D++D  L  +    +E    +                G ET  NT  + ++ ++ 
Sbjct: 251 AGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLH 310

Query: 535 NEDVQRKLHQEIDDIIGRDRNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           + ++Q++L +E+D  +G   +       DR R+    A I E LR+  V  + +PH    
Sbjct: 311 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 370

Query: 706 DAKLGNYIIPKGTFILLSLYXLH-HGPHWKDPXTFRPERFL 825
            + +  Y IP+GT I+ +L   H     W+ P  F P+RFL
Sbjct: 371 PSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL 411


>M21550-1|AAA52063.1|  495|Homo sapiens CYP21 protein.
          Length = 495

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 65/281 (23%), Positives = 122/281 (43%), Gaps = 9/281 (3%)
 Frame = +1

Query: 10  DFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLC 189
           D M   + +  +   +   A  G P+ + + F +   +I+  L  G +   +D  +    
Sbjct: 134 DSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYY 192

Query: 190 SLVMRLFKLVD-MSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQ 366
             +  + K     S  I++ +PFLR F P   G   L++        +   +++H+E+L 
Sbjct: 193 KCIQEVLKTWSHWSIQIVDVIPFLRFF-PNP-GLRRLKQAIEKRDHIVEMQLRQHKESLV 250

Query: 367 LGAPKDVIDAFLIDM----LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVR 534
            G  +D++D  L  +    +E    +                G ET  NT  + ++ ++ 
Sbjct: 251 AGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHLHMAAVDLLIGGTETTANTLSWAVVFLLH 310

Query: 535 NEDVQRKLHQEIDDIIGRDRNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           + ++Q++L +E+D  +G   +       DR R+    A I E LR+  V  + +PH    
Sbjct: 311 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 370

Query: 706 DAKLGNYIIPKGTFILLSLYXLH-HGPHWKDPXTFRPERFL 825
            + +  Y IP+GT I+ +L   H     W+ P  F P+RFL
Sbjct: 371 PSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL 411


>M18907-1|AAA35745.1|  503|Homo sapiens protein ( Human P450 mRNA
           encoding nifedipine oxidase, complete cds. ).
          Length = 503

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 62/262 (23%), Positives = 115/262 (43%), Gaps = 8/262 (3%)
 Frame = +1

Query: 61  RLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGIL 240
           R A+ G+P+ +  +F    ++++     G   D  +           +L +   +    L
Sbjct: 162 REAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFL 221

Query: 241 NFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKDVIDAFLIDMLES 420
           +   F   F+  ++    +      +  +LR+ +K  +E+      K  +D FL  M++S
Sbjct: 222 SITVF--PFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVD-FLQLMIDS 278

Query: 421 QDDKXXXXXXXXXXXXXXE-------AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDI 579
           Q+ K                      AG ET ++   F++  +  + DVQ+KL +EID +
Sbjct: 279 QNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAV 338

Query: 580 IGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLS 759
           +        D  ++M Y + V+ ETLR+  +A M +  +   D ++    IPKG  +++ 
Sbjct: 339 LPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIP 397

Query: 760 LYXLHHGP-HWKDPXTFRPERF 822
            Y LH  P +W +P  F PERF
Sbjct: 398 SYALHRDPKYWTEPEKFLPERF 419


>M13936-1|AAA59695.1|  494|Homo sapiens CYP21P protein.
          Length = 494

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 65/281 (23%), Positives = 122/281 (43%), Gaps = 9/281 (3%)
 Frame = +1

Query: 10  DFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLC 189
           D M   + +  +   +   A  G P+ + + F +   +I+  L  G +   +D  +    
Sbjct: 133 DSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYY 191

Query: 190 SLVMRLFKLVD-MSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQ 366
             +  + K     S  I++ +PFLR F P   G   L++        +   +++H+E+L 
Sbjct: 192 KCIQEVLKTWSHWSIQIVDVIPFLRFF-PNP-GLRRLKQAIEKRDHIVEMQLRQHKESLV 249

Query: 367 LGAPKDVIDAFLIDM----LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVR 534
            G  +D++D  L  +    +E    +                G ET  NT  + ++ ++ 
Sbjct: 250 AGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLH 309

Query: 535 NEDVQRKLHQEIDDIIGRDRNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           + ++Q++L +E+D  +G   +       DR R+    A I E LR+  V  + +PH    
Sbjct: 310 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 369

Query: 706 DAKLGNYIIPKGTFILLSLYXLH-HGPHWKDPXTFRPERFL 825
            + +  Y IP+GT I+ +L   H     W+ P  F P+RFL
Sbjct: 370 PSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL 410


>M12792-1|AAB59440.1|  494|Homo sapiens steroid 21-hydroxylase
           protein.
          Length = 494

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 65/281 (23%), Positives = 122/281 (43%), Gaps = 9/281 (3%)
 Frame = +1

Query: 10  DFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLC 189
           D M   + +  +   +   A  G P+ + + F +   +I+  L  G +   +D  +    
Sbjct: 133 DSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYY 191

Query: 190 SLVMRLFKLVD-MSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQ 366
             +  + K     S  I++ +PFLR F P   G   L++        +   +++H+E+L 
Sbjct: 192 KCIQEVLKTWSHWSIQIVDVIPFLRFF-PNP-GLRRLKQAIEKRDHIVEMQLRQHKESLV 249

Query: 367 LGAPKDVIDAFLIDM----LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVR 534
            G  +D++D  L  +    +E    +                G ET  NT  + ++ ++ 
Sbjct: 250 AGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLH 309

Query: 535 NEDVQRKLHQEIDDIIGRDRNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           + ++Q++L +E+D  +G   +       DR R+    A I E LR+  V  + +PH    
Sbjct: 310 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 369

Query: 706 DAKLGNYIIPKGTFILLSLYXLH-HGPHWKDPXTFRPERFL 825
            + +  Y IP+GT I+ +L   H     W+ P  F P+RFL
Sbjct: 370 PSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL 410


>J04449-1|AAA35747.1|  502|Homo sapiens cytochrome P450 nifedipine
           oxidase protein.
          Length = 502

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 66/263 (25%), Positives = 118/263 (44%), Gaps = 9/263 (3%)
 Frame = +1

Query: 61  RLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGIL 240
           R A+ G+P+ +  +F    ++++     G   D  +           +L +   +    L
Sbjct: 162 REAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFL 221

Query: 241 NFL-PFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKDVIDAFLIDMLE 417
           + + PFL   +  L      +E+ N    +LR+ +K  +E+      K  +D FL  M++
Sbjct: 222 SIIFPFLIPILEVLNICVFPREVTN----FLRKSVKRMKESRLEDTQKHRVD-FLQLMID 276

Query: 418 SQDDKXXXXXXXXXXXXXXE-------AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDD 576
           SQ+ K                      AG ET ++   F++  +  + DVQ+KL +EID 
Sbjct: 277 SQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDA 336

Query: 577 IIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILL 756
           ++        D  ++M Y + V+ ETLR+  +A M +  +   D ++    IPKG  +++
Sbjct: 337 VLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGWVVMI 395

Query: 757 SLYXLHHGP-HWKDPXTFRPERF 822
             Y LH  P +W +P  F PERF
Sbjct: 396 PSYALHRDPKYWTEPEKFLPERF 418


>DQ924960-1|ABI96208.1|  503|Homo sapiens cytochrome P450 family 3
           subfamily A polypeptide 4 protein.
          Length = 503

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 62/262 (23%), Positives = 115/262 (43%), Gaps = 8/262 (3%)
 Frame = +1

Query: 61  RLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGIL 240
           R A+ G+P+ +  +F    ++++     G   D  +           +L +   +    L
Sbjct: 162 REAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFL 221

Query: 241 NFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKDVIDAFLIDMLES 420
           +   F   F+  ++    +      +  +LR+ +K  +E+      K  +D FL  M++S
Sbjct: 222 SITVF--PFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVD-FLQLMIDS 278

Query: 421 QDDKXXXXXXXXXXXXXXE-------AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDI 579
           Q+ K                      AG ET ++   F++  +  + DVQ+KL +EID +
Sbjct: 279 QNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAV 338

Query: 580 IGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLS 759
           +        D  ++M Y + V+ ETLR+  +A M +  +   D ++    IPKG  +++ 
Sbjct: 339 LPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIP 397

Query: 760 LYXLHHGP-HWKDPXTFRPERF 822
            Y LH  P +W +P  F PERF
Sbjct: 398 SYALHRDPKYWTEPEKFLPERF 419


>DQ005611-1|AAY16980.1|  503|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 4 protein.
          Length = 503

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 62/262 (23%), Positives = 115/262 (43%), Gaps = 8/262 (3%)
 Frame = +1

Query: 61  RLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGIL 240
           R A+ G+P+ +  +F    ++++     G   D  +           +L +   +    L
Sbjct: 162 REAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFL 221

Query: 241 NFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKDVIDAFLIDMLES 420
           +   F   F+  ++    +      +  +LR+ +K  +E+      K  +D FL  M++S
Sbjct: 222 SITVF--PFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVD-FLQLMIDS 278

Query: 421 QDDKXXXXXXXXXXXXXXE-------AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDI 579
           Q+ K                      AG ET ++   F++  +  + DVQ+KL +EID +
Sbjct: 279 QNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAV 338

Query: 580 IGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLS 759
           +        D  ++M Y + V+ ETLR+  +A M +  +   D ++    IPKG  +++ 
Sbjct: 339 LPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIP 397

Query: 760 LYXLHHGP-HWKDPXTFRPERF 822
            Y LH  P +W +P  F PERF
Sbjct: 398 SYALHRDPKYWTEPEKFLPERF 419


>BX679671-8|CAM26070.1|  494|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 494

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 65/281 (23%), Positives = 122/281 (43%), Gaps = 9/281 (3%)
 Frame = +1

Query: 10  DFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLC 189
           D M   + +  +   +   A  G P+ + + F +   +I+  L  G +   +D  +    
Sbjct: 133 DSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYY 191

Query: 190 SLVMRLFKLVD-MSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQ 366
             +  + K     S  I++ +PFLR F P   G   L++        +   +++H+E+L 
Sbjct: 192 KCIQEVLKTWSHWSIQIVDVIPFLRFF-PNP-GLRRLKQAIEKRDHIVEMQLRQHKESLV 249

Query: 367 LGAPKDVIDAFLIDM----LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVR 534
            G  +D++D  L  +    +E    +                G ET  NT  + ++ ++ 
Sbjct: 250 AGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLH 309

Query: 535 NEDVQRKLHQEIDDIIGRDRNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           + ++Q++L +E+D  +G   +       DR R+    A I E LR+  V  + +PH    
Sbjct: 310 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 369

Query: 706 DAKLGNYIIPKGTFILLSLYXLH-HGPHWKDPXTFRPERFL 825
            + +  Y IP+GT I+ +L   H     W+ P  F P+RFL
Sbjct: 370 PSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL 410


>BX679671-7|CAM26071.1|  464|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 464

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 65/281 (23%), Positives = 122/281 (43%), Gaps = 9/281 (3%)
 Frame = +1

Query: 10  DFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLC 189
           D M   + +  +   +   A  G P+ + + F +   +I+  L  G +   +D  +    
Sbjct: 103 DSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYY 161

Query: 190 SLVMRLFKLVD-MSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQ 366
             +  + K     S  I++ +PFLR F P   G   L++        +   +++H+E+L 
Sbjct: 162 KCIQEVLKTWSHWSIQIVDVIPFLRFF-PNP-GLRRLKQAIEKRDHIVEMQLRQHKESLV 219

Query: 367 LGAPKDVIDAFLIDM----LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVR 534
            G  +D++D  L  +    +E    +                G ET  NT  + ++ ++ 
Sbjct: 220 AGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLH 279

Query: 535 NEDVQRKLHQEIDDIIGRDRNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           + ++Q++L +E+D  +G   +       DR R+    A I E LR+  V  + +PH    
Sbjct: 280 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 339

Query: 706 DAKLGNYIIPKGTFILLSLYXLH-HGPHWKDPXTFRPERFL 825
            + +  Y IP+GT I+ +L   H     W+ P  F P+RFL
Sbjct: 340 PSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL 380


>BX538127-1|CAD98029.1|  310|Homo sapiens hypothetical protein
           protein.
          Length = 310

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 44/117 (37%), Positives = 67/117 (57%), Gaps = 1/117 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           AG ET + T  + LL +++  +V  K+ +EI+ ++GR+R+  + DR  M YT+AV+ E  
Sbjct: 117 AGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQ 176

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           R   +    +PH    D K  NY+IPKGT I+ SL   LH+   + +P  F P  FL
Sbjct: 177 RYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFL 233


>BC125182-1|AAI25183.1|  494|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 494

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 65/281 (23%), Positives = 122/281 (43%), Gaps = 9/281 (3%)
 Frame = +1

Query: 10  DFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLC 189
           D M   + +  +   +   A  G P+ + + F +   +I+  L  G +   +D  +    
Sbjct: 133 DSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYY 191

Query: 190 SLVMRLFKLVD-MSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQ 366
             +  + K     S  I++ +PFLR F P   G   L++        +   +++H+E+L 
Sbjct: 192 KCIQEVLKTWSHWSIQIVDVIPFLRFF-PNP-GLRRLKQAIEKRDHIVEMQLRQHKESLV 249

Query: 367 LGAPKDVIDAFLIDM----LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVR 534
            G  +D++D  L  +    +E    +                G ET  NT  + ++ ++ 
Sbjct: 250 AGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLH 309

Query: 535 NEDVQRKLHQEIDDIIGRDRNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           + ++Q++L +E+D  +G   +       DR R+    A I E LR+  V  + +PH    
Sbjct: 310 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 369

Query: 706 DAKLGNYIIPKGTFILLSLYXLH-HGPHWKDPXTFRPERFL 825
            + +  Y IP+GT I+ +L   H     W+ P  F P+RFL
Sbjct: 370 PSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL 410


>BC125181-1|AAI25182.1|  495|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 495

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 65/281 (23%), Positives = 122/281 (43%), Gaps = 9/281 (3%)
 Frame = +1

Query: 10  DFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLC 189
           D M   + +  +   +   A  G P+ + + F +   +I+  L  G +   +D  +    
Sbjct: 134 DSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYY 192

Query: 190 SLVMRLFKLVD-MSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQ 366
             +  + K     S  I++ +PFLR F P   G   L++        +   +++H+E+L 
Sbjct: 193 KCIQEVLKTWSHWSIQIVDVIPFLRFF-PNP-GLRRLKQAIEKRDHIVEMQLRQHKESLV 250

Query: 367 LGAPKDVIDAFLIDM----LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVR 534
            G  +D++D  L  +    +E    +                G ET  NT  + ++ ++ 
Sbjct: 251 AGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLH 310

Query: 535 NEDVQRKLHQEIDDIIGRDRNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           + ++Q++L +E+D  +G   +       DR R+    A I E LR+  V  + +PH    
Sbjct: 311 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 370

Query: 706 DAKLGNYIIPKGTFILLSLYXLH-HGPHWKDPXTFRPERFL 825
            + +  Y IP+GT I+ +L   H     W+ P  F P+RFL
Sbjct: 371 PSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL 411


>BC101631-1|AAI01632.1|  503|Homo sapiens cytochrome P450, subfamily
           IIIA, polypeptide 4 protein.
          Length = 503

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 62/262 (23%), Positives = 115/262 (43%), Gaps = 8/262 (3%)
 Frame = +1

Query: 61  RLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGIL 240
           R A+ G+P+ +  +F    ++++     G   D  +           +L +   +    L
Sbjct: 162 REAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFL 221

Query: 241 NFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKDVIDAFLIDMLES 420
           +   F   F+  ++    +      +  +LR+ +K  +E+      K  +D FL  M++S
Sbjct: 222 SITVF--PFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVD-FLQLMIDS 278

Query: 421 QDDKXXXXXXXXXXXXXXE-------AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDI 579
           Q+ K                      AG ET ++   F++  +  + DVQ+KL +EID +
Sbjct: 279 QNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAV 338

Query: 580 IGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLS 759
           +        D  ++M Y + V+ ETLR+  +A M +  +   D ++    IPKG  +++ 
Sbjct: 339 LPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIP 397

Query: 760 LYXLHHGP-HWKDPXTFRPERF 822
            Y LH  P +W +P  F PERF
Sbjct: 398 SYALHRDPKYWTEPEKFLPERF 419


>BC096260-1|AAH96260.1|  431|Homo sapiens CYP2C18 protein protein.
          Length = 431

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 44/117 (37%), Positives = 67/117 (57%), Gaps = 1/117 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           AG ET + T  + LL +++  +V  K+ +EI+ ++GR+R+  + DR  M YT+AV+ E  
Sbjct: 238 AGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQ 297

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           R   +    +PH    D K  NY+IPKGT I+ SL   LH+   + +P  F P  FL
Sbjct: 298 RYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFL 354


>BC069418-1|AAH69418.1|  503|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 4 protein.
          Length = 503

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 62/262 (23%), Positives = 115/262 (43%), Gaps = 8/262 (3%)
 Frame = +1

Query: 61  RLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGIL 240
           R A+ G+P+ +  +F    ++++     G   D  +           +L +   +    L
Sbjct: 162 REAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFL 221

Query: 241 NFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKDVIDAFLIDMLES 420
           +   F   F+  ++    +      +  +LR+ +K  +E+      K  +D FL  M++S
Sbjct: 222 SITVF--PFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVD-FLQLMIDS 278

Query: 421 QDDKXXXXXXXXXXXXXXE-------AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDI 579
           Q+ K                      AG ET ++   F++  +  + DVQ+KL +EID +
Sbjct: 279 QNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAV 338

Query: 580 IGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLS 759
           +        D  ++M Y + V+ ETLR+  +A M +  +   D ++    IPKG  +++ 
Sbjct: 339 LPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIP 397

Query: 760 LYXLHHGP-HWKDPXTFRPERF 822
            Y LH  P +W +P  F PERF
Sbjct: 398 SYALHRDPKYWTEPEKFLPERF 419


>AM183951-1|CAJ75805.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 65/281 (23%), Positives = 122/281 (43%), Gaps = 9/281 (3%)
 Frame = +1

Query: 10  DFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLC 189
           D M   + +  +   +   A  G P+ + + F +   +I+  L  G +   +D  +    
Sbjct: 133 DSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYY 191

Query: 190 SLVMRLFKLVD-MSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQ 366
             +  + K     S  I++ +PFLR F P   G   L++        +   +++H+E+L 
Sbjct: 192 KCIQEVLKTWSHWSIQIVDVIPFLRFF-PNP-GLRRLKQAIEKRDHIVEMQLRQHKESLV 249

Query: 367 LGAPKDVIDAFLIDM----LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVR 534
            G  +D++D  L  +    +E    +                G ET  NT  + ++ ++ 
Sbjct: 250 AGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLH 309

Query: 535 NEDVQRKLHQEIDDIIGRDRNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           + ++Q++L +E+D  +G   +       DR R+    A I E LR+  V  + +PH    
Sbjct: 310 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 369

Query: 706 DAKLGNYIIPKGTFILLSLYXLH-HGPHWKDPXTFRPERFL 825
            + +  Y IP+GT I+ +L   H     W+ P  F P+RFL
Sbjct: 370 PSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL 410


>AM183950-1|CAJ75804.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 65/281 (23%), Positives = 122/281 (43%), Gaps = 9/281 (3%)
 Frame = +1

Query: 10  DFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLC 189
           D M   + +  +   +   A  G P+ + + F +   +I+  L  G +   +D  +    
Sbjct: 133 DSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYY 191

Query: 190 SLVMRLFKLVD-MSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQ 366
             +  + K     S  I++ +PFLR F P   G   L++        +   +++H+E+L 
Sbjct: 192 KCIQEVLKTWSHWSIQIVDVIPFLRFF-PNP-GLRRLKQAIEKRDHIVEMQLRQHKESLV 249

Query: 367 LGAPKDVIDAFLIDM----LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVR 534
            G  +D++D  L  +    +E    +                G ET  NT  + ++ ++ 
Sbjct: 250 AGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLH 309

Query: 535 NEDVQRKLHQEIDDIIGRDRNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           + ++Q++L +E+D  +G   +       DR R+    A I E LR+  V  + +PH    
Sbjct: 310 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHCTTR 369

Query: 706 DAKLGNYIIPKGTFILLSLYXLH-HGPHWKDPXTFRPERFL 825
            + +  Y IP+GT I+ +L   H     W+ P  F P+RFL
Sbjct: 370 PSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL 410


>AM086565-1|CAJ31104.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 65/281 (23%), Positives = 122/281 (43%), Gaps = 9/281 (3%)
 Frame = +1

Query: 10  DFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLC 189
           D M   + +  +   +   A  G P+ + + F +   +I+  L  G +   +D  +    
Sbjct: 133 DSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYY 191

Query: 190 SLVMRLFKLVD-MSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQ 366
             +  + K     S  I++ +PFLR F P   G   L++        +   +++H+E+L 
Sbjct: 192 KCIQEVLKTWSHWSIQIVDVIPFLRFF-PNP-GLRRLKQAIEKRDHIVEMQLRQHKESLV 249

Query: 367 LGAPKDVIDAFLIDM----LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVR 534
            G  +D++D  L  +    +E    +                G ET  NT  + ++ ++ 
Sbjct: 250 AGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLH 309

Query: 535 NEDVQRKLHQEIDDIIGRDRNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           + ++Q++L +E+D  +G   +       DR R+    A I E LR+  V  + +PH    
Sbjct: 310 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 369

Query: 706 DAKLGNYIIPKGTFILLSLYXLH-HGPHWKDPXTFRPERFL 825
            + +  Y IP+GT I+ +L   H     W+ P  F P+RFL
Sbjct: 370 PSSISGYDIPEGTVIIPNLQGTHLDETVWERPHEFWPDRFL 410


>AL929593-2|CAI41778.1|  465|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 465

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 65/281 (23%), Positives = 122/281 (43%), Gaps = 9/281 (3%)
 Frame = +1

Query: 10  DFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLC 189
           D M   + +  +   +   A  G P+ + + F +   +I+  L  G +   +D  +    
Sbjct: 104 DSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYY 162

Query: 190 SLVMRLFKLVD-MSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQ 366
             +  + K     S  I++ +PFLR F P   G   L++        +   +++H+E+L 
Sbjct: 163 KCIQEVLKTWSHWSIQIVDVIPFLRFF-PNP-GLRRLKQAIEKRDHIVEMQLRQHKESLV 220

Query: 367 LGAPKDVIDAFLIDM----LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVR 534
            G  +D++D  L  +    +E    +                G ET  NT  + ++ ++ 
Sbjct: 221 AGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLH 280

Query: 535 NEDVQRKLHQEIDDIIGRDRNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           + ++Q++L +E+D  +G   +       DR R+    A I E LR+  V  + +PH    
Sbjct: 281 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 340

Query: 706 DAKLGNYIIPKGTFILLSLYXLH-HGPHWKDPXTFRPERFL 825
            + +  Y IP+GT I+ +L   H     W+ P  F P+RFL
Sbjct: 341 PSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL 381


>AL929593-1|CAI41779.1|  495|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 495

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 65/281 (23%), Positives = 122/281 (43%), Gaps = 9/281 (3%)
 Frame = +1

Query: 10  DFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLC 189
           D M   + +  +   +   A  G P+ + + F +   +I+  L  G +   +D  +    
Sbjct: 134 DSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYY 192

Query: 190 SLVMRLFKLVD-MSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQ 366
             +  + K     S  I++ +PFLR F P   G   L++        +   +++H+E+L 
Sbjct: 193 KCIQEVLKTWSHWSIQIVDVIPFLRFF-PNP-GLRRLKQAIEKRDHIVEMQLRQHKESLV 250

Query: 367 LGAPKDVIDAFLIDM----LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVR 534
            G  +D++D  L  +    +E    +                G ET  NT  + ++ ++ 
Sbjct: 251 AGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLH 310

Query: 535 NEDVQRKLHQEIDDIIGRDRNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           + ++Q++L +E+D  +G   +       DR R+    A I E LR+  V  + +PH    
Sbjct: 311 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 370

Query: 706 DAKLGNYIIPKGTFILLSLYXLH-HGPHWKDPXTFRPERFL 825
            + +  Y IP+GT I+ +L   H     W+ P  F P+RFL
Sbjct: 371 PSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL 411


>AL662849-19|CAI17480.1|  465|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 465

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 65/281 (23%), Positives = 122/281 (43%), Gaps = 9/281 (3%)
 Frame = +1

Query: 10  DFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLC 189
           D M   + +  +   +   A  G P+ + + F +   +I+  L  G +   +D  +    
Sbjct: 104 DSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYY 162

Query: 190 SLVMRLFKLVD-MSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQ 366
             +  + K     S  I++ +PFLR F P   G   L++        +   +++H+E+L 
Sbjct: 163 KCIQEVLKTWSHWSIQIVDVIPFLRFF-PNP-GLRRLKQAIEKRDHIVEMQLRQHKESLV 220

Query: 367 LGAPKDVIDAFLIDM----LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVR 534
            G  +D++D  L  +    +E    +                G ET  NT  + ++ ++ 
Sbjct: 221 AGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLH 280

Query: 535 NEDVQRKLHQEIDDIIGRDRNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           + ++Q++L +E+D  +G   +       DR R+    A I E LR+  V  + +PH    
Sbjct: 281 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 340

Query: 706 DAKLGNYIIPKGTFILLSLYXLH-HGPHWKDPXTFRPERFL 825
            + +  Y IP+GT I+ +L   H     W+ P  F P+RFL
Sbjct: 341 PSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL 381


>AL662849-18|CAI17479.1|  495|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 495

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 65/281 (23%), Positives = 122/281 (43%), Gaps = 9/281 (3%)
 Frame = +1

Query: 10  DFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLC 189
           D M   + +  +   +   A  G P+ + + F +   +I+  L  G +   +D  +    
Sbjct: 134 DSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYY 192

Query: 190 SLVMRLFKLVD-MSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQ 366
             +  + K     S  I++ +PFLR F P   G   L++        +   +++H+E+L 
Sbjct: 193 KCIQEVLKTWSHWSIQIVDVIPFLRFF-PNP-GLRRLKQAIEKRDHIVEMQLRQHKESLV 250

Query: 367 LGAPKDVIDAFLIDM----LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVR 534
            G  +D++D  L  +    +E    +                G ET  NT  + ++ ++ 
Sbjct: 251 AGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLH 310

Query: 535 NEDVQRKLHQEIDDIIGRDRNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           + ++Q++L +E+D  +G   +       DR R+    A I E LR+  V  + +PH    
Sbjct: 311 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 370

Query: 706 DAKLGNYIIPKGTFILLSLYXLH-HGPHWKDPXTFRPERFL 825
            + +  Y IP+GT I+ +L   H     W+ P  F P+RFL
Sbjct: 371 PSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL 411


>AL645922-24|CAI41754.1|  495|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 495

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 65/281 (23%), Positives = 122/281 (43%), Gaps = 9/281 (3%)
 Frame = +1

Query: 10  DFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLC 189
           D M   + +  +   +   A  G P+ + + F +   +I+  L  G +   +D  +    
Sbjct: 134 DSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYY 192

Query: 190 SLVMRLFKLVD-MSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQ 366
             +  + K     S  I++ +PFLR F P   G   L++        +   +++H+E+L 
Sbjct: 193 KCIQEVLKTWSHWSIQIVDVIPFLRFF-PNP-GLRRLKQAIEKRDHIVEMQLRQHKESLV 250

Query: 367 LGAPKDVIDAFLIDM----LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVR 534
            G  +D++D  L  +    +E    +                G ET  NT  + ++ ++ 
Sbjct: 251 AGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLH 310

Query: 535 NEDVQRKLHQEIDDIIGRDRNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           + ++Q++L +E+D  +G   +       DR R+    A I E LR+  V  + +PH    
Sbjct: 311 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 370

Query: 706 DAKLGNYIIPKGTFILLSLYXLH-HGPHWKDPXTFRPERFL 825
            + +  Y IP+GT I+ +L   H     W+ P  F P+RFL
Sbjct: 371 PSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL 411


>AL645922-23|CAI41755.1|  465|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 465

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 65/281 (23%), Positives = 122/281 (43%), Gaps = 9/281 (3%)
 Frame = +1

Query: 10  DFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLC 189
           D M   + +  +   +   A  G P+ + + F +   +I+  L  G +   +D  +    
Sbjct: 104 DSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYY 162

Query: 190 SLVMRLFKLVD-MSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQ 366
             +  + K     S  I++ +PFLR F P   G   L++        +   +++H+E+L 
Sbjct: 163 KCIQEVLKTWSHWSIQIVDVIPFLRFF-PNP-GLRRLKQAIEKRDHIVEMQLRQHKESLV 220

Query: 367 LGAPKDVIDAFLIDM----LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVR 534
            G  +D++D  L  +    +E    +                G ET  NT  + ++ ++ 
Sbjct: 221 AGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLH 280

Query: 535 NEDVQRKLHQEIDDIIGRDRNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           + ++Q++L +E+D  +G   +       DR R+    A I E LR+  V  + +PH    
Sbjct: 281 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 340

Query: 706 DAKLGNYIIPKGTFILLSLYXLH-HGPHWKDPXTFRPERFL 825
            + +  Y IP+GT I+ +L   H     W+ P  F P+RFL
Sbjct: 341 PSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL 381


>AL049547-7|CAB89301.1|  495|Homo sapiens dJ34F7.3 (cytochrome P450,
           subfamily XXIA (steroid 21-hydroxylase, congenital a
           protein.
          Length = 495

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 65/281 (23%), Positives = 122/281 (43%), Gaps = 9/281 (3%)
 Frame = +1

Query: 10  DFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLC 189
           D M   + +  +   +   A  G P+ + + F +   +I+  L  G +   +D  +    
Sbjct: 134 DSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYY 192

Query: 190 SLVMRLFKLVD-MSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQ 366
             +  + K     S  I++ +PFLR F P   G   L++        +   +++H+E+L 
Sbjct: 193 KCIQEVLKTWSHWSIQIVDVIPFLRFF-PNP-GLRRLKQAIEKRDHIVEMQLRQHKESLV 250

Query: 367 LGAPKDVIDAFLIDM----LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVR 534
            G  +D++D  L  +    +E    +                G ET  NT  + ++ ++ 
Sbjct: 251 AGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLH 310

Query: 535 NEDVQRKLHQEIDDIIGRDRNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           + ++Q++L +E+D  +G   +       DR R+    A I E LR+  V  + +PH    
Sbjct: 311 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 370

Query: 706 DAKLGNYIIPKGTFILLSLYXLH-HGPHWKDPXTFRPERFL 825
            + +  Y IP+GT I+ +L   H     W+ P  F P+RFL
Sbjct: 371 PSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL 411


>AJ563376-2|CAD91645.1|  430|Homo sapiens cytochrome P450 protein.
          Length = 430

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 62/262 (23%), Positives = 115/262 (43%), Gaps = 8/262 (3%)
 Frame = +1

Query: 61  RLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGIL 240
           R A+ G+P+ +  +F    ++++     G   D  +           +L +   +    L
Sbjct: 89  REAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFL 148

Query: 241 NFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKDVIDAFLIDMLES 420
           +   F   F+  ++    +      +  +LR+ +K  +E+      K  +D FL  M++S
Sbjct: 149 SITVF--PFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVD-FLQLMIDS 205

Query: 421 QDDKXXXXXXXXXXXXXXE-------AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDI 579
           Q+ K                      AG ET ++   F++  +  + DVQ+KL +EID +
Sbjct: 206 QNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAV 265

Query: 580 IGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLS 759
           +        D  ++M Y + V+ ETLR+  +A M +  +   D ++    IPKG  +++ 
Sbjct: 266 LPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIP 324

Query: 760 LYXLHHGP-HWKDPXTFRPERF 822
            Y LH  P +W +P  F PERF
Sbjct: 325 SYALHRDPKYWTEPEKFLPERF 346


>AJ563375-1|CAD91343.1|  503|Homo sapiens cytochrome P450 protein.
          Length = 503

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 62/262 (23%), Positives = 115/262 (43%), Gaps = 8/262 (3%)
 Frame = +1

Query: 61  RLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGIL 240
           R A+ G+P+ +  +F    ++++     G   D  +           +L +   +    L
Sbjct: 162 REAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFL 221

Query: 241 NFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKDVIDAFLIDMLES 420
           +   F   F+  ++    +      +  +LR+ +K  +E+      K  +D FL  M++S
Sbjct: 222 SITVF--PFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVD-FLQLMIDS 278

Query: 421 QDDKXXXXXXXXXXXXXXE-------AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDI 579
           Q+ K                      AG ET ++   F++  +  + DVQ+KL +EID +
Sbjct: 279 QNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAV 338

Query: 580 IGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLS 759
           +        D  ++M Y + V+ ETLR+  +A M +  +   D ++    IPKG  +++ 
Sbjct: 339 LPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIP 397

Query: 760 LYXLHHGP-HWKDPXTFRPERF 822
            Y LH  P +W +P  F PERF
Sbjct: 398 SYALHRDPKYWTEPEKFLPERF 419


>AF280107-2|AAG32290.1|  503|Homo sapiens cytochrome P450
           polypeptide 4 protein.
          Length = 503

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 62/262 (23%), Positives = 115/262 (43%), Gaps = 8/262 (3%)
 Frame = +1

Query: 61  RLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGIL 240
           R A+ G+P+ +  +F    ++++     G   D  +           +L +   +    L
Sbjct: 162 REAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFL 221

Query: 241 NFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKDVIDAFLIDMLES 420
           +   F   F+  ++    +      +  +LR+ +K  +E+      K  +D FL  M++S
Sbjct: 222 SITVF--PFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVD-FLQLMIDS 278

Query: 421 QDDKXXXXXXXXXXXXXXE-------AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDI 579
           Q+ K                      AG ET ++   F++  +  + DVQ+KL +EID +
Sbjct: 279 QNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAV 338

Query: 580 IGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLS 759
           +        D  ++M Y + V+ ETLR+  +A M +  +   D ++    IPKG  +++ 
Sbjct: 339 LPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIP 397

Query: 760 LYXLHHGP-HWKDPXTFRPERF 822
            Y LH  P +W +P  F PERF
Sbjct: 398 SYALHRDPKYWTEPEKFLPERF 419


>AF209389-1|AAF21034.1|  503|Homo sapiens cytochrome P450 IIIA4
           protein.
          Length = 503

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 62/262 (23%), Positives = 115/262 (43%), Gaps = 8/262 (3%)
 Frame = +1

Query: 61  RLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGIL 240
           R A+ G+P+ +  +F    ++++     G   D  +           +L +   +    L
Sbjct: 162 REAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFL 221

Query: 241 NFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKDVIDAFLIDMLES 420
           +   F   F+  ++    +      +  +LR+ +K  +E+      K  +D FL  M++S
Sbjct: 222 SITVF--PFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVD-FLQLMIDS 278

Query: 421 QDDKXXXXXXXXXXXXXXE-------AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDI 579
           Q+ K                      AG ET ++   F++  +  + DVQ+KL +EID +
Sbjct: 279 QNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAV 338

Query: 580 IGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLS 759
           +        D  ++M Y + V+ ETLR+  +A M +  +   D ++    IPKG  +++ 
Sbjct: 339 LPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIP 397

Query: 760 LYXLHHGP-HWKDPXTFRPERF 822
            Y LH  P +W +P  F PERF
Sbjct: 398 SYALHRDPKYWTEPEKFLPERF 419


>AF182273-1|AAF13598.1|  503|Homo sapiens cytochrome P450-3A4
           protein.
          Length = 503

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 62/262 (23%), Positives = 115/262 (43%), Gaps = 8/262 (3%)
 Frame = +1

Query: 61  RLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGIL 240
           R A+ G+P+ +  +F    ++++     G   D  +           +L +   +    L
Sbjct: 162 REAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFL 221

Query: 241 NFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKDVIDAFLIDMLES 420
           +   F   F+  ++    +      +  +LR+ +K  +E+      K  +D FL  M++S
Sbjct: 222 SITVF--PFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVD-FLQLMIDS 278

Query: 421 QDDKXXXXXXXXXXXXXXE-------AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDI 579
           Q+ K                      AG ET ++   F++  +  + DVQ+KL +EID +
Sbjct: 279 QNSKETESHKALSDLELVAQSIIFIFAGCETTSSVLSFIMYELATHPDVQQKLQEEIDAV 338

Query: 580 IGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLS 759
           +        D  ++M Y + V+ ETLR+  +A M +  +   D ++    IPKG  +++ 
Sbjct: 339 LPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIP 397

Query: 760 LYXLHHGP-HWKDPXTFRPERF 822
            Y LH  P +W +P  F PERF
Sbjct: 398 SYALHRDPKYWTEPEKFLPERF 419


>AF077974-1|AAD45405.1|  403|Homo sapiens cytochrome P450
           21-hydroxylase protein.
          Length = 403

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 65/281 (23%), Positives = 122/281 (43%), Gaps = 9/281 (3%)
 Frame = +1

Query: 10  DFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLC 189
           D M   + +  +   +   A  G P+ + + F +   +I+  L  G +   +D  +    
Sbjct: 42  DSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYY 100

Query: 190 SLVMRLFKLVD-MSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQ 366
             +  + K     S  I++ +PFLR F P   G   L++        +   +++H+E+L 
Sbjct: 101 KCIQEVLKTWSHWSIQIVDVIPFLRFF-PNP-GLRRLKQAIEKRDHIVEMQLRQHKESLV 158

Query: 367 LGAPKDVIDAFLIDM----LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVR 534
            G  +D++D  L  +    +E    +                G ET  NT  + ++ ++ 
Sbjct: 159 AGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLH 218

Query: 535 NEDVQRKLHQEIDDIIGRDRNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           + ++Q++L +E+D  +G   +       DR R+    A I E LR+  V  + +PH    
Sbjct: 219 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 278

Query: 706 DAKLGNYIIPKGTFILLSLYXLH-HGPHWKDPXTFRPERFL 825
            + +  Y IP+GT I+ +L   H     W+ P  F P+RFL
Sbjct: 279 PSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL 319


>AF019413-2|AAB67982.1|  495|Homo sapiens cytochrome P450
           21-hydroxylase protein.
          Length = 495

 Score = 85.4 bits (202), Expect = 2e-16
 Identities = 65/281 (23%), Positives = 122/281 (43%), Gaps = 9/281 (3%)
 Frame = +1

Query: 10  DFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLC 189
           D M   + +  +   +   A  G P+ + + F +   +I+  L  G +   +D  +    
Sbjct: 134 DSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYY 192

Query: 190 SLVMRLFKLVD-MSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQ 366
             +  + K     S  I++ +PFLR F P   G   L++        +   +++H+E+L 
Sbjct: 193 KCIQEVLKTWSHWSIQIVDVIPFLRFF-PNP-GLRRLKQAIEKRDHIVEMQLRQHKESLV 250

Query: 367 LGAPKDVIDAFLIDM----LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVR 534
            G  +D++D  L  +    +E    +                G ET  NT  + ++ ++ 
Sbjct: 251 AGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLH 310

Query: 535 NEDVQRKLHQEIDDIIGRDRNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           + ++Q++L +E+D  +G   +       DR R+    A I E LR+  V  + +PH    
Sbjct: 311 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 370

Query: 706 DAKLGNYIIPKGTFILLSLYXLH-HGPHWKDPXTFRPERFL 825
            + +  Y IP+GT I+ +L   H     W+ P  F P+RFL
Sbjct: 371 PSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL 411


>J04813-1|AAA02993.1|  502|Homo sapiens cytochrome P450 PCN3
           protein.
          Length = 502

 Score = 85.0 bits (201), Expect = 3e-16
 Identities = 42/116 (36%), Positives = 65/116 (56%), Gaps = 1/116 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           AG ET ++   F L  +  + DVQ+KL +EID ++        D  ++M Y + V+ ETL
Sbjct: 305 AGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETL 364

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDPXTFRPERF 822
           R+  VA + +      D ++    IPKG+ +++  Y LHH P +W +P  FRPERF
Sbjct: 365 RLFPVA-IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF 419


>BC033862-1|AAH33862.1|  502|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 5 protein.
          Length = 502

 Score = 85.0 bits (201), Expect = 3e-16
 Identities = 42/116 (36%), Positives = 65/116 (56%), Gaps = 1/116 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           AG ET ++   F L  +  + DVQ+KL +EID ++        D  ++M Y + V+ ETL
Sbjct: 305 AGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETL 364

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDPXTFRPERF 822
           R+  VA + +      D ++    IPKG+ +++  Y LHH P +W +P  FRPERF
Sbjct: 365 RLFPVA-IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF 419


>AC005020-1|AAS02016.1|  502|Homo sapiens unknown protein.
          Length = 502

 Score = 85.0 bits (201), Expect = 3e-16
 Identities = 42/116 (36%), Positives = 65/116 (56%), Gaps = 1/116 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           AG ET ++   F L  +  + DVQ+KL +EID ++        D  ++M Y + V+ ETL
Sbjct: 305 AGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETL 364

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDPXTFRPERF 822
           R+  VA + +      D ++    IPKG+ +++  Y LHH P +W +P  FRPERF
Sbjct: 365 RLFPVA-IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF 419


>X12387-1|CAA30944.1|  503|Homo sapiens protein ( Human mRNA for
           cytochrome P-450 (cyp3 locus). ).
          Length = 503

 Score = 84.6 bits (200), Expect = 4e-16
 Identities = 62/262 (23%), Positives = 115/262 (43%), Gaps = 8/262 (3%)
 Frame = +1

Query: 61  RLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGIL 240
           R A+ G+P+ +  +F    ++++     G   D  +           +L +   +    L
Sbjct: 162 REAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFL 221

Query: 241 NFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKDVIDAFLIDMLES 420
           +   F   F+  ++    +      +  +LR+ +K  +E+      K  +D FL  M++S
Sbjct: 222 SITVF--PFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVD-FLQLMIDS 278

Query: 421 QDDKXXXXXXXXXXXXXXE-------AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDI 579
           Q+ K                      AG ET ++   F++  +  + DVQ+KL +EID +
Sbjct: 279 QNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAV 338

Query: 580 IGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLS 759
           +        D  ++M Y + V+ ETLR+  +A M +  +   D ++    IPKG  +++ 
Sbjct: 339 LPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGWVVMIP 397

Query: 760 LYXLHHGP-HWKDPXTFRPERF 822
            Y LH  P +W +P  F PERF
Sbjct: 398 SYALHRDPKYWTEPEKFLPERF 419


>M14096-1|AAA35744.1|  503|Homo sapiens protein ( Human cytochrome
           P-450 nifedipine oxidase mRNA, complet cds. ).
          Length = 503

 Score = 84.6 bits (200), Expect = 4e-16
 Identities = 62/262 (23%), Positives = 115/262 (43%), Gaps = 8/262 (3%)
 Frame = +1

Query: 61  RLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSGGIL 240
           R A+ G+P+ +  +F    ++++     G   D  +           +L +   +    L
Sbjct: 162 REAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFL 221

Query: 241 NFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKDVIDAFLIDMLES 420
           +   F   F+  ++    +      +  +LR+ +K  +E+      K  +D FL  M++S
Sbjct: 222 SITVF--PFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVD-FLQLMIDS 278

Query: 421 QDDKXXXXXXXXXXXXXXE-------AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDI 579
           Q+ K                      AG ET ++   F++  +  + DVQ+KL +EID +
Sbjct: 279 QNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAV 338

Query: 580 IGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLS 759
           +        D  ++M Y + V+ ETLR+  +A M +  +   D ++    IPKG  +++ 
Sbjct: 339 LPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGWVVMIP 397

Query: 760 LYXLHHGP-HWKDPXTFRPERF 822
            Y LH  P +W +P  F PERF
Sbjct: 398 SYALHRDPKYWTEPEKFLPERF 419


>AM183949-1|CAJ75803.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 84.6 bits (200), Expect = 4e-16
 Identities = 65/281 (23%), Positives = 121/281 (43%), Gaps = 9/281 (3%)
 Frame = +1

Query: 10  DFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLC 189
           D M   + +  +   +   A  G P+ + + F +   +I+  L  G +   +D  +    
Sbjct: 133 DSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYY 191

Query: 190 SLVMRLFKLVD-MSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQ 366
             +  + K     S  I++ +PFLR F P   G   L++        +   +++H+E+L 
Sbjct: 192 KCIQEVLKTWSHWSIQIVDVIPFLRFF-PNP-GLRRLKQAIEKRDHIVEMQLRQHKESLV 249

Query: 367 LGAPKDVIDAFLIDM----LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVR 534
            G  +D++D  L  +    +E    +                G ET  NT  + ++ +  
Sbjct: 250 AGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLFH 309

Query: 535 NEDVQRKLHQEIDDIIGRDRNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           + ++Q++L +E+D  +G   +       DR R+    A I E LR+  V  + +PH    
Sbjct: 310 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 369

Query: 706 DAKLGNYIIPKGTFILLSLYXLH-HGPHWKDPXTFRPERFL 825
            + +  Y IP+GT I+ +L   H     W+ P  F P+RFL
Sbjct: 370 PSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL 410


>AM183947-1|CAJ75801.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 84.6 bits (200), Expect = 4e-16
 Identities = 65/281 (23%), Positives = 122/281 (43%), Gaps = 9/281 (3%)
 Frame = +1

Query: 10  DFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLC 189
           D M   + +  +   +   A  G P+ + + F +   +I+  L  G +   +D  +    
Sbjct: 133 DSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYY 191

Query: 190 SLVMRLFKLVD-MSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQ 366
             +  + K     S  I++ +PFLR F P   G   L++        +   +++H+E+L 
Sbjct: 192 KCIQEVLKTWSHWSIQIVDVIPFLRFF-PNP-GLRRLKQAIEKGDHIVEMQLRQHKESLV 249

Query: 367 LGAPKDVIDAFLIDM----LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVR 534
            G  +D++D  L  +    +E    +                G ET  NT  + ++ ++ 
Sbjct: 250 AGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLH 309

Query: 535 NEDVQRKLHQEIDDIIGRDRNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           + ++Q++L +E+D  +G   +       DR R+    A I E LR+  V  + +PH    
Sbjct: 310 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 369

Query: 706 DAKLGNYIIPKGTFILLSLYXLH-HGPHWKDPXTFRPERFL 825
            + +  Y IP+GT I+ +L   H     W+ P  F P+RFL
Sbjct: 370 PSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL 410


>AM183946-1|CAJ75800.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 84.6 bits (200), Expect = 4e-16
 Identities = 63/262 (24%), Positives = 116/262 (44%), Gaps = 9/262 (3%)
 Frame = +1

Query: 67  ADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVD-MSGGILN 243
           A  G P+ + + F +   +I+  L  G +   +D  +      +  + K     S  I++
Sbjct: 152 AQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVD 210

Query: 244 FLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKDVIDAFLIDM---- 411
            +PFLR F P   G   L++        +   +++H+E+L  G  +D++D  L  +    
Sbjct: 211 VIPFLRFF-PNP-GLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPS 268

Query: 412 LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRD 591
           +E    +                G ET  NT  + ++ ++ + ++Q++L +E+D  +G  
Sbjct: 269 MEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPG 328

Query: 592 RNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLSL 762
            +       DR R+    A I E LR+  V  + +PH     + +  Y IP+GT I+ +L
Sbjct: 329 ASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNL 388

Query: 763 YXLH-HGPHWKDPXTFRPERFL 825
              H     W+ P  F P+RFL
Sbjct: 389 QGAHLDETVWERPHEFWPDRFL 410


>AM183945-1|CAJ75799.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 84.6 bits (200), Expect = 4e-16
 Identities = 63/262 (24%), Positives = 116/262 (44%), Gaps = 9/262 (3%)
 Frame = +1

Query: 67  ADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVD-MSGGILN 243
           A  G P+ + + F +   +I+  L  G +   +D  +      +  + K     S  I++
Sbjct: 152 AQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVD 210

Query: 244 FLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLGAPKDVIDAFLIDM---- 411
            +PFLR F P   G   L++        +   +++H+E+L  G  +D++D  L  +    
Sbjct: 211 VIPFLRFF-PNP-GLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPS 268

Query: 412 LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRD 591
           +E    +                G ET  NT  + ++ ++ + ++Q++L +E+D  +G  
Sbjct: 269 MEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPG 328

Query: 592 RNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLSL 762
            +       DR R+    A I E LR+  V  + +PH     + +  Y IP+GT I+ +L
Sbjct: 329 ASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNL 388

Query: 763 YXLH-HGPHWKDPXTFRPERFL 825
              H     W+ P  F P+RFL
Sbjct: 389 QGAHLDETVWERPHEFWPDRFL 410


>X58906-1|CAA41709.1|  495|Homo sapiens steroid 21-monooxygenase
           protein.
          Length = 495

 Score = 83.4 bits (197), Expect = 9e-16
 Identities = 64/281 (22%), Positives = 121/281 (43%), Gaps = 9/281 (3%)
 Frame = +1

Query: 10  DFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLC 189
           D M   + +  +   +   A  G P+ + + F +   +I+  L  G +   +D  +    
Sbjct: 134 DSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYY 192

Query: 190 SLVMRLFKLVD-MSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQ 366
             +  + K     S  I++ +PFLR F P   G   L++        +   +++H+E+L 
Sbjct: 193 KCIQEVLKTWSHWSIQIVDVIPFLRFF-PNP-GLRRLKQAIEKRDHIVEMQLRQHKESLV 250

Query: 367 LGAPKDVIDAFLIDM----LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVR 534
            G  +D++D  L  +    +E    +                G ET  NT  + ++ ++ 
Sbjct: 251 AGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLH 310

Query: 535 NEDVQRKLHQEIDDIIGRDRNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           + ++Q++L +E+D  +G   +       D  R+    A I E LR+  V  + +PH    
Sbjct: 311 HPEIQQRLQEELDHELGPGASSSRVPYKDHARLPLLNATIAEVLRLRPVVPLALPHRTTR 370

Query: 706 DAKLGNYIIPKGTFILLSLYXLH-HGPHWKDPXTFRPERFL 825
            + +  Y IP+GT I+ +L   H     W+ P  F P+RFL
Sbjct: 371 PSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL 411


>AM183948-1|CAJ75802.1|  494|Homo sapiens steroid 21-hydroxylase
           protein.
          Length = 494

 Score = 83.4 bits (197), Expect = 9e-16
 Identities = 64/281 (22%), Positives = 121/281 (43%), Gaps = 9/281 (3%)
 Frame = +1

Query: 10  DFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLC 189
           D M   + +  +   +   A  G P+ + + F +   +I+  L  G +   +D  +    
Sbjct: 133 DSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYY 191

Query: 190 SLVMRLFKLVD-MSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQ 366
             +  + K     S  I++ +PFLR F P   G   L++        +   +++H+E+L 
Sbjct: 192 KCIQEVLKTWSHWSIQIVDVIPFLRFF-PNP-GLRRLKQAIEKRDHIVEMQLRQHKESLV 249

Query: 367 LGAPKDVIDAFLIDM----LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVR 534
            G  +D++D  L  +    +E    +                G E   NT  + ++ ++ 
Sbjct: 250 AGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTENTANTLSWAVVFLLH 309

Query: 535 NEDVQRKLHQEIDDIIGRDRNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           + ++Q++L +E+D  +G   +       DR R+    A I E LR+  V  + +PH    
Sbjct: 310 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 369

Query: 706 DAKLGNYIIPKGTFILLSLYXLH-HGPHWKDPXTFRPERFL 825
            + +  Y IP+GT I+ +L   H     W+ P  F P+RFL
Sbjct: 370 PSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL 410


>AM086564-1|CAJ31103.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 83.4 bits (197), Expect = 9e-16
 Identities = 65/281 (23%), Positives = 121/281 (43%), Gaps = 9/281 (3%)
 Frame = +1

Query: 10  DFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLC 189
           D M   + +  +   +   A  G P+ + + F     +I+  L  G +   +D  +    
Sbjct: 133 DSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSPLTCSIICYLTFGDKIK-DDNLMPAYY 191

Query: 190 SLVMRLFKLVD-MSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQ 366
             +  + K     S  I++ +PFLR F P   G   L++        +   +++H+E+L 
Sbjct: 192 KCIQEVLKTWSHWSIQIVDVIPFLRFF-PNP-GLRRLKQAIEKRDHIVEMQLRQHKESLV 249

Query: 367 LGAPKDVIDAFLIDM----LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVR 534
            G  +D++D  L  +    +E    +                G ET  NT  + ++ ++ 
Sbjct: 250 AGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLH 309

Query: 535 NEDVQRKLHQEIDDIIGRDRNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           + ++Q++L +E+D  +G   +       DR R+    A I E LR+  V  + +PH    
Sbjct: 310 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 369

Query: 706 DAKLGNYIIPKGTFILLSLYXLH-HGPHWKDPXTFRPERFL 825
            + +  Y IP+GT I+ +L   H     W+ P  F P+RFL
Sbjct: 370 PSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL 410


>AJ563377-1|CAD91345.1|  353|Homo sapiens cytochrome P450 protein.
          Length = 353

 Score = 83.4 bits (197), Expect = 9e-16
 Identities = 51/174 (29%), Positives = 85/174 (48%), Gaps = 8/174 (4%)
 Frame = +1

Query: 325 YLREIIKEHQENLQLGAPKDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXE-------AG 483
           +LR+ +K  +E+      K  +D FL  M++SQ+ K                      AG
Sbjct: 98  FLRKSVKRMKESRLEDTQKHRVD-FLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAG 156

Query: 484 METVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRI 663
            ET ++   F++  +  + DVQ+KL +EID ++        D  ++M Y + V+ ETLR+
Sbjct: 157 YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL 216

Query: 664 STVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDPXTFRPERF 822
             +A M +  +   D ++    IPKG  +++  Y LH  P +W +P  F PERF
Sbjct: 217 FPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF 269


>AY390424-1|AAQ92352.1|  503|Homo sapiens cytochrome P450 CYP3A43.3
           protein.
          Length = 503

 Score = 81.4 bits (192), Expect = 4e-15
 Identities = 39/116 (33%), Positives = 64/116 (55%), Gaps = 1/116 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           A  +T + T  F++  +  + DVQ+KL +EID ++        D  ++M Y + V+ ETL
Sbjct: 305 AAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLANKAPVTYDALVQMEYLDMVVNETL 364

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDPXTFRPERF 822
           R+  V S  +  +   D ++    IPKG  +++ +Y LHH P +W +P  F PERF
Sbjct: 365 RLFPVVSR-VTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERF 419


>BC100981-1|AAI00982.1|  393|Homo sapiens CYP3A43 protein protein.
          Length = 393

 Score = 80.6 bits (190), Expect = 6e-15
 Identities = 39/116 (33%), Positives = 64/116 (55%), Gaps = 1/116 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           A  +T + T  F++  +  + DVQ+KL +EID ++        D  ++M Y + V+ ETL
Sbjct: 195 AAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETL 254

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDPXTFRPERF 822
           R+  V S  +  +   D ++    IPKG  +++ +Y LHH P +W +P  F PERF
Sbjct: 255 RLFPVVSR-VTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERF 309


>AY390425-1|AAQ92353.1|  503|Homo sapiens cytochrome P450 CYP3A43.1
           protein.
          Length = 503

 Score = 80.6 bits (190), Expect = 6e-15
 Identities = 39/116 (33%), Positives = 64/116 (55%), Gaps = 1/116 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           A  +T + T  F++  +  + DVQ+KL +EID ++        D  ++M Y + V+ ETL
Sbjct: 305 AAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETL 364

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDPXTFRPERF 822
           R+  V S  +  +   D ++    IPKG  +++ +Y LHH P +W +P  F PERF
Sbjct: 365 RLFPVVSR-VTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERF 419


>AF337813-1|AAK38841.1|  503|Homo sapiens cytochrome P450 subfamily
           IIIA polypeptide 43 protein.
          Length = 503

 Score = 80.6 bits (190), Expect = 6e-15
 Identities = 39/116 (33%), Positives = 64/116 (55%), Gaps = 1/116 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           A  +T + T  F++  +  + DVQ+KL +EID ++        D  ++M Y + V+ ETL
Sbjct: 305 AAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETL 364

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDPXTFRPERF 822
           R+  V S  +  +   D ++    IPKG  +++ +Y LHH P +W +P  F PERF
Sbjct: 365 RLFPVVSR-VTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERF 419


>AF319634-1|AAK00325.1|  503|Homo sapiens cytochrome P450 CYP3A43
           protein.
          Length = 503

 Score = 80.6 bits (190), Expect = 6e-15
 Identities = 39/116 (33%), Positives = 64/116 (55%), Gaps = 1/116 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           A  +T + T  F++  +  + DVQ+KL +EID ++        D  ++M Y + V+ ETL
Sbjct: 305 AAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETL 364

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDPXTFRPERF 822
           R+  V S  +  +   D ++    IPKG  +++ +Y LHH P +W +P  F PERF
Sbjct: 365 RLFPVVSR-VTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERF 419


>AF280108-1|AAG33009.1|  503|Homo sapiens cytochrome P450 subfamily
           IIIA polypeptide 43 protein.
          Length = 503

 Score = 80.6 bits (190), Expect = 6e-15
 Identities = 39/116 (33%), Positives = 64/116 (55%), Gaps = 1/116 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           A  +T + T  F++  +  + DVQ+KL +EID ++        D  ++M Y + V+ ETL
Sbjct: 305 AAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETL 364

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDPXTFRPERF 822
           R+  V S  +  +   D ++    IPKG  +++ +Y LHH P +W +P  F PERF
Sbjct: 365 RLFPVVSR-VTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERF 419


>AC011904-4|AAS07395.1|  503|Homo sapiens unknown protein.
          Length = 503

 Score = 80.6 bits (190), Expect = 6e-15
 Identities = 39/116 (33%), Positives = 64/116 (55%), Gaps = 1/116 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           A  +T + T  F++  +  + DVQ+KL +EID ++        D  ++M Y + V+ ETL
Sbjct: 305 AAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETL 364

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDPXTFRPERF 822
           R+  V S  +  +   D ++    IPKG  +++ +Y LHH P +W +P  F PERF
Sbjct: 365 RLFPVVSR-VTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERF 419


>AK054616-1|BAB70774.1|  465|Homo sapiens protein ( Homo sapiens
           cDNA FLJ30054 fis, clone ADRGL1000160, highly similar to
           CYTOCHROME P450 XXIB (EC 1.14.99.10). ).
          Length = 465

 Score = 80.2 bits (189), Expect = 8e-15
 Identities = 64/281 (22%), Positives = 119/281 (42%), Gaps = 9/281 (3%)
 Frame = +1

Query: 10  DFMNVYIGEECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLC 189
           D M   + +  +   +   A    P+ + + F +   +I+  L  G +   +D  +    
Sbjct: 104 DSMEPVVEQLTQEFCERMRAQPDTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYY 162

Query: 190 SLVMRLFKLVD-MSGGILNFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQ 366
             +  + K     S  I++ +PFLR F P   G   L++        +   + +H+E+L 
Sbjct: 163 KCIQEVLKTWSHWSIQIVDVIPFLRFF-PNP-GLRRLKQAIEKRDHIVEMQLGQHKESLV 220

Query: 367 LGAPKDVIDAFLIDM----LESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVR 534
            G  +D++D  L  +    +E    +                G ET  NT  +  + ++ 
Sbjct: 221 AGQWRDMMDYMLQGVAQPSMEEGSGQLQEGHVHMAAVDLLIGGTETTANTLSWAAVFLLH 280

Query: 535 NEDVQRKLHQEIDDIIGRDRNHL---LDDRIRMVYTEAVILETLRISTVASMGIPHMALN 705
           + ++Q++L +E+D  +G   +       DR R+    A I E LR+  V  + +PH    
Sbjct: 281 HPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTR 340

Query: 706 DAKLGNYIIPKGTFILLSLYXLH-HGPHWKDPXTFRPERFL 825
            + +  Y IP+GT I+ +L   H     W+ P  F P+RFL
Sbjct: 341 PSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL 381


>M13785-1|AAA35742.1|  504|Homo sapiens protein ( Human liver
           glucocorticoid-inducible cytochrome P-450 (HLp) mRNA,
           complete cds. ).
          Length = 504

 Score = 79.8 bits (188), Expect = 1e-14
 Identities = 39/116 (33%), Positives = 64/116 (55%), Gaps = 1/116 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           AG ET ++   F++  +  + DVQ+KL +EID ++        D  ++M Y + V+ ETL
Sbjct: 306 AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETL 365

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDPXTFRPERF 822
           R+  +A M +  +   D ++    IPKG  +++  Y LH  P +W +P  F PERF
Sbjct: 366 RLFPIA-MRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERF 420


>D00003-1|BAA00001.1|  504|Homo sapiens cytochrome P-450 protein.
          Length = 504

 Score = 79.8 bits (188), Expect = 1e-14
 Identities = 39/116 (33%), Positives = 64/116 (55%), Gaps = 1/116 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           AG ET ++   F++  +  + DVQ+KL +EID ++        D  ++M Y + V+ ETL
Sbjct: 306 AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETL 365

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDPXTFRPERF 822
           R+  +A M +  +   D ++    IPKG  +++  Y LH  P +W +P  F PERF
Sbjct: 366 RLFPIA-MRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERF 420


>BC100982-1|AAI00983.1|  280|Homo sapiens CYP3A43 protein protein.
          Length = 280

 Score = 78.2 bits (184), Expect = 3e-14
 Identities = 38/115 (33%), Positives = 63/115 (54%), Gaps = 1/115 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           A  +T + T  F++  +  + DVQ+KL +EID ++        D  ++M Y + V+ ETL
Sbjct: 165 AAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETL 224

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDPXTFRPER 819
           R+  V S  +  +   D ++    IPKG  +++ +Y LHH P +W +P  F PER
Sbjct: 225 RLFPVVSR-VTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 278


>AF280110-1|AAG33011.1|  420|Homo sapiens cytochrome P450 subfamily
           IIIA polypeptide 43 protein.
          Length = 420

 Score = 78.2 bits (184), Expect = 3e-14
 Identities = 38/115 (33%), Positives = 63/115 (54%), Gaps = 1/115 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           A  +T + T  F++  +  + DVQ+KL +EID ++        D  ++M Y + V+ ETL
Sbjct: 305 AAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETL 364

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDPXTFRPER 819
           R+  V S  +  +   D ++    IPKG  +++ +Y LHH P +W +P  F PER
Sbjct: 365 RLFPVVSR-VTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418


>BC025761-1|AAH25761.2|  490|Homo sapiens cytochrome P450, family 2,
           subfamily W, polypeptide 1 protein.
          Length = 490

 Score = 77.4 bits (182), Expect = 6e-14
 Identities = 64/240 (26%), Positives = 110/240 (45%), Gaps = 5/240 (2%)
 Frame = +1

Query: 121 NILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSG-GILNFLPFLRHFVPRLIGFTEL 297
           NI + L+ G+R+D  D     L  L+  +  L+   G  + N  P+L   +   +    L
Sbjct: 177 NITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQ--LHRPVL 234

Query: 298 QEIHNALHQYLREIIKEHQENLQLGAPK-DVIDAFLIDMLESQDDKXXXXXXXXXXXXXX 474
           ++I   +   LR +++  + ++  G P    +DA LI   +  D +              
Sbjct: 235 RKIEE-VRAILRTLLEARRPHVCPGDPVCSYVDA-LIQQGQGDDPEGLFAEANAVACTLD 292

Query: 475 E--AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVIL 648
              AG ET + T  +  L + R+ DVQ ++ +E+D ++G  R   L+D+  + YT AV+ 
Sbjct: 293 MVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLH 352

Query: 649 ETLRISTVASMGIPHMALNDAKLGNYIIPKGTFIL-LSLYXLHHGPHWKDPXTFRPERFL 825
           E  R  T+    +P     D +LG +++PKGT ++ L    L     W+ P  F P  FL
Sbjct: 353 EVQRFITLLP-HVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFL 411


>AK000366-1|BAA91114.1|  408|Homo sapiens protein ( Homo sapiens
           cDNA FLJ20359 fis, clone HEP16626. ).
          Length = 408

 Score = 76.6 bits (180), Expect = 1e-13
 Identities = 64/240 (26%), Positives = 110/240 (45%), Gaps = 5/240 (2%)
 Frame = +1

Query: 121 NILWRLVAGKRYDLEDQRLKKLCSLVMRLFKLVDMSG-GILNFLPFLRHFVPRLIGFTEL 297
           NI + L+ G+R+D  D     L  L+  +  L+   G  + N  P+L   +   +    L
Sbjct: 121 NITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVHPWLGALLQ--LHRPVL 178

Query: 298 QEIHNALHQYLREIIKEHQENLQLGAPK-DVIDAFLIDMLESQDDKXXXXXXXXXXXXXX 474
           ++I   +   LR +++  + ++  G P    +DA LI   +  D +              
Sbjct: 179 RKIEE-VRAILRTLLEARRPHVCPGDPVCSYVDA-LIQQGQGDDPEGLFAEANAVACTLD 236

Query: 475 E--AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVIL 648
              AG ET + T  +  L + R+ DVQ ++ +E+D ++G  R   L+D+  + YT AV+ 
Sbjct: 237 MVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLH 296

Query: 649 ETLRISTVASMGIPHMALNDAKLGNYIIPKGTFIL-LSLYXLHHGPHWKDPXTFRPERFL 825
           E  R  T+    +P     D +LG +++PKGT ++ L    L     W+ P  F P  FL
Sbjct: 297 EVQRFITLLP-HVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFL 355


>L16883-1|AAD13467.1|  169|Homo sapiens cytochrome P-450 2C protein.
          Length = 169

 Score = 76.2 bits (179), Expect = 1e-13
 Identities = 38/92 (41%), Positives = 53/92 (57%), Gaps = 1/92 (1%)
 Frame = +1

Query: 553 KLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYII 732
           K+ +EI+ +IGR+R+  + DR  M YT+AV+ E  R   +    +PH    D K  NY+I
Sbjct: 1   KVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYLDLLPTSLPHAVTCDIKFRNYLI 60

Query: 733 PKGTFILLSLYX-LHHGPHWKDPXTFRPERFL 825
           PKGT IL+SL   LH    + +P  F P  FL
Sbjct: 61  PKGTTILISLTSVLHDNKEFPNPEMFDPHHFL 92


>AF280109-1|AAG33010.1|  504|Homo sapiens cytochrome P450 subfamily
           IIIA polypeptide 43 protein.
          Length = 504

 Score = 76.2 bits (179), Expect = 1e-13
 Identities = 37/114 (32%), Positives = 62/114 (54%), Gaps = 1/114 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           A  +T + T  F++  +  + DVQ+KL +EID ++        D  ++M Y + V+ ETL
Sbjct: 305 AAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETL 364

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDPXTFRPE 816
           R+  V S  +  +   D ++    IPKG  +++ +Y LHH P +W +P  F PE
Sbjct: 365 RLFPVVSR-VTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPE 417


>AC011904-5|AAS07394.1|  504|Homo sapiens unknown protein.
          Length = 504

 Score = 76.2 bits (179), Expect = 1e-13
 Identities = 37/114 (32%), Positives = 62/114 (54%), Gaps = 1/114 (0%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           A  +T + T  F++  +  + DVQ+KL +EID ++        D  ++M Y + V+ ETL
Sbjct: 305 AAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETL 364

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDPXTFRPE 816
           R+  V S  +  +   D ++    IPKG  +++ +Y LHH P +W +P  F PE
Sbjct: 365 RLFPVVSR-VTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPE 417


>BC022539-1|AAH22539.1|  500|Homo sapiens cytochrome P450, family
           46, subfamily A, polypeptide 1 protein.
          Length = 500

 Score = 72.5 bits (170), Expect = 2e-12
 Identities = 69/269 (25%), Positives = 117/269 (43%), Gaps = 6/269 (2%)
 Frame = +1

Query: 34  EECEALVQL--RLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           E+ E LV++    AD   P+ +  M   T ++IL +   G    +     K L   V  +
Sbjct: 159 EKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLM 218

Query: 208 FKLVDMSGGIL-NFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLG--AP 378
            + +  S   L  FLP  R  +       E++E    L Q  R+ ++  +E L+ G   P
Sbjct: 219 LEGITASRNTLAKFLPGKRKQL------REVRESIRFLRQVGRDWVQRRREALKRGEEVP 272

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVRNEDVQRKL 558
            D++   L     +QDD+               AG ET  N   F ++ + R  ++  +L
Sbjct: 273 ADILTQILKAEEGAQDDEGLLDNFVTFFI----AGHETSANHLAFTVMELSRQPEIVARL 328

Query: 559 HQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPK 738
             E+D++IG  R    +D  R+ Y   V+ E+LR+   A  G   +   +  +    +P 
Sbjct: 329 QAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPA-WGTFRLLEEETLIDGVRVPG 387

Query: 739 GTFILLSLYXL-HHGPHWKDPXTFRPERF 822
            T +L S Y +     +++DP TF P+RF
Sbjct: 388 NTPLLFSTYVMGRMDTYFEDPLTFNPDRF 416


>AF094480-1|AAD41244.1|  500|Homo sapiens cholesterol 24-hydroxylase
           protein.
          Length = 500

 Score = 72.5 bits (170), Expect = 2e-12
 Identities = 69/269 (25%), Positives = 117/269 (43%), Gaps = 6/269 (2%)
 Frame = +1

Query: 34  EECEALVQL--RLADAGEPILVNQMFHITIVNILWRLVAGKRYDLEDQRLKKLCSLVMRL 207
           E+ E LV++    AD   P+ +  M   T ++IL +   G    +     K L   V  +
Sbjct: 159 EKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLM 218

Query: 208 FKLVDMSGGIL-NFLPFLRHFVPRLIGFTELQEIHNALHQYLREIIKEHQENLQLG--AP 378
            + +  S   L  FLP  R  +       E++E    L Q  R+ ++  +E L+ G   P
Sbjct: 219 LEGITASRNTLAKFLPGKRKQL------REVRESIRFLRQVGRDWVQRRREALKRGEEVP 272

Query: 379 KDVIDAFLIDMLESQDDKXXXXXXXXXXXXXXEAGMETVTNTAVFMLLHVVRNEDVQRKL 558
            D++   L     +QDD+               AG ET  N   F ++ + R  ++  +L
Sbjct: 273 ADILTQILKAEEGAQDDEGLLDNFVTFFI----AGHETSANHLAFTVMELSRQPEIVARL 328

Query: 559 HQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPK 738
             E+D++IG  R    +D  R+ Y   V+ E+LR+   A  G   +   +  +    +P 
Sbjct: 329 QAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPA-WGTFRLLEEETLIDGVRVPG 387

Query: 739 GTFILLSLYXL-HHGPHWKDPXTFRPERF 822
            T +L S Y +     +++DP TF P+RF
Sbjct: 388 NTPLLFSTYVMGRMDTYFEDPLTFNPDRF 416


>DQ016495-1|AAY34975.1|  195|Homo sapiens cytochrome P450 1B1
           protein.
          Length = 195

 Score = 67.3 bits (157), Expect = 6e-11
 Identities = 31/96 (32%), Positives = 52/96 (54%), Gaps = 1/96 (1%)
 Frame = +1

Query: 541 DVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETLRISTVASMGIPHMALNDAKLG 720
           DVQ ++  E+D ++GRDR   + D+  + Y  A + E +R S+   + I H    +  + 
Sbjct: 3   DVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTISHATTANTSVL 62

Query: 721 NYIIPKGTFILLSLYXLHHGP-HWKDPXTFRPERFL 825
            Y IPK T + ++ + ++H P  W +P  F P RFL
Sbjct: 63  GYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFL 98


>M17252-1|AAA59985.1|  230|Homo sapiens CYP21 protein.
          Length = 230

 Score = 65.7 bits (153), Expect = 2e-10
 Identities = 36/119 (30%), Positives = 61/119 (51%), Gaps = 4/119 (3%)
 Frame = +1

Query: 481 GMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHL---LDDRIRMVYTEAVILE 651
           G ET  NT  + ++ ++ + ++Q++L +E+D  +G   +       DR R+    A I E
Sbjct: 28  GTETTANTLSWAVVFLLHHLEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLIATIAE 87

Query: 652 TLRISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLH-HGPHWKDPXTFRPERFL 825
            LR+  V  + +PH     + +  Y IP+GT I+ +L   H     W+ P  F P+RFL
Sbjct: 88  VLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL 146


>S67623-1|AAB29308.1|  257|Homo sapiens 25-hydroxyvitamin D
           24-hydroxylase cytochrome P450 subunit protein.
          Length = 257

 Score = 63.7 bits (148), Expect = 8e-10
 Identities = 38/118 (32%), Positives = 68/118 (57%), Gaps = 2/118 (1%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           A +ET  N+ +++L ++ RN  VQ+KL +EI  ++  ++    +D   M Y +A + E++
Sbjct: 69  AAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESM 128

Query: 658 RISTVASMGIPHMALNDAK-LGNYIIPKGTFILLSLYXLHHG-PHWKDPXTFRPERFL 825
           R++   S+      L+ A  LG Y +PKGT ++L+   L     +++D   FRPER+L
Sbjct: 129 RLTP--SVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWL 184


>BC060857-1|AAH60857.1|  525|Homo sapiens cytochrome P450, family 4,
           subfamily V, polypeptide 2 protein.
          Length = 525

 Score = 63.7 bits (148), Expect = 8e-10
 Identities = 37/116 (31%), Positives = 61/116 (52%), Gaps = 2/116 (1%)
 Frame = +1

Query: 481 GMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGR-DRNHLLDDRIRMVYTEAVILETL 657
           G +T      + L  +  N +VQ+K+  E+DD+ G+ DR   ++D  ++ Y E VI ETL
Sbjct: 330 GHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETL 389

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDPXTFRPERF 822
           R+     +        D ++  Y + KGT  ++  Y LH  P ++ +P  F+PERF
Sbjct: 390 RLFPSVPL-FARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERF 444


>AY858838-1|AAW50795.1|  372|Homo sapiens vitamin D 24-hydroxylase
           splice variant protein.
          Length = 372

 Score = 63.7 bits (148), Expect = 8e-10
 Identities = 38/118 (32%), Positives = 68/118 (57%), Gaps = 2/118 (1%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           A +ET  N+ +++L ++ RN  VQ+KL +EI  ++  ++    +D   M Y +A + E++
Sbjct: 184 AAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESM 243

Query: 658 RISTVASMGIPHMALNDAK-LGNYIIPKGTFILLSLYXLHHG-PHWKDPXTFRPERFL 825
           R++   S+      L+ A  LG Y +PKGT ++L+   L     +++D   FRPER+L
Sbjct: 244 RLTP--SVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWL 299


>AY422002-1|AAR31180.1|  525|Homo sapiens cytochrome P450 4V2
           protein.
          Length = 525

 Score = 63.7 bits (148), Expect = 8e-10
 Identities = 37/116 (31%), Positives = 61/116 (52%), Gaps = 2/116 (1%)
 Frame = +1

Query: 481 GMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGR-DRNHLLDDRIRMVYTEAVILETL 657
           G +T      + L  +  N +VQ+K+  E+DD+ G+ DR   ++D  ++ Y E VI ETL
Sbjct: 330 GHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETL 389

Query: 658 RISTVASMGIPHMALNDAKLGNYIIPKGTFILLSLYXLHHGP-HWKDPXTFRPERF 822
           R+     +        D ++  Y + KGT  ++  Y LH  P ++ +P  F+PERF
Sbjct: 390 RLFPSVPL-FARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERF 444


>AL138805-2|CAB91829.1|  514|Homo sapiens cytochrome P450, family
           24, subfamily A, polypeptide 1 protein.
          Length = 514

 Score = 63.7 bits (148), Expect = 8e-10
 Identities = 38/118 (32%), Positives = 68/118 (57%), Gaps = 2/118 (1%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           A +ET  N+ +++L ++ RN  VQ+KL +EI  ++  ++    +D   M Y +A + E++
Sbjct: 326 AAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESM 385

Query: 658 RISTVASMGIPHMALNDAK-LGNYIIPKGTFILLSLYXLHHG-PHWKDPXTFRPERFL 825
           R++   S+      L+ A  LG Y +PKGT ++L+   L     +++D   FRPER+L
Sbjct: 386 RLTP--SVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWL 441


>AL138805-1|CAM27342.1|  372|Homo sapiens cytochrome P450, family
           24, subfamily A, polypeptide 1 protein.
          Length = 372

 Score = 63.7 bits (148), Expect = 8e-10
 Identities = 38/118 (32%), Positives = 68/118 (57%), Gaps = 2/118 (1%)
 Frame = +1

Query: 478 AGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNHLLDDRIRMVYTEAVILETL 657
           A +ET  N+ +++L ++ RN  VQ+KL +EI  ++  ++    +D   M Y +A + E++
Sbjct: 184 AAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESM 243

Query: 658 RISTVASMGIPHMALNDAK-LGNYIIPKGTFILLSLYXLHHG-PHWKDPXTFRPERFL 825
           R++   S+      L+ A  LG Y +PKGT ++L+   L     +++D   FRPER+L
Sbjct: 244 RLTP--SVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWL 299


  Database: human
    Posted date:  Oct 23, 2007  1:18 PM
  Number of letters in database: 76,859,062
  Number of sequences in database:  237,096
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.279   0.0580    0.190 


Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 122,456,029
Number of Sequences: 237096
Number of extensions: 2582088
Number of successful extensions: 5416
Number of sequences better than 10.0: 399
Number of HSP's better than 10.0 without gapping: 4929
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5059
length of database: 76,859,062
effective HSP length: 89
effective length of database: 55,757,518
effective search space used: 10370898348
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)