Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fbpv0935
(649 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q9XYB0 Cluster: PugilistDominant; n=2; Coelomata|Rep: P... 142 9e-33
UniRef50_UPI00015B59A5 Cluster: PREDICTED: similar to ENSANGP000... 133 4e-30
UniRef50_P11586 Cluster: C-1-tetrahydrofolate synthase, cytoplas... 110 2e-23
UniRef50_Q4T2B9 Cluster: Chromosome undetermined SCAF10300, whol... 106 4e-22
UniRef50_O84081 Cluster: Bifunctional protein folD [Includes: Me... 91 3e-17
UniRef50_Q5PBL6 Cluster: Bifunctional protein folD [Includes: Me... 90 5e-17
UniRef50_Q21285 Cluster: Dauer or aging adult overexpression pro... 84 2e-15
UniRef50_O65271 Cluster: F6N23.26 protein; n=20; Viridiplantae|R... 84 3e-15
UniRef50_Q7MVE9 Cluster: Bifunctional protein folD [Includes: Me... 83 6e-15
UniRef50_Q9LHH7 Cluster: 5,10-methylenetetrahydrofolate dehydrog... 81 2e-14
UniRef50_O65269 Cluster: F6N23.28 protein; n=1; Arabidopsis thal... 81 2e-14
UniRef50_Q16F77 Cluster: Methylenetetrahydrofolate dehydrogenase... 80 4e-14
UniRef50_Q9A8Y0 Cluster: Bifunctional protein folD [Includes: Me... 80 5e-14
UniRef50_Q63SL6 Cluster: Bifunctional protein folD [Includes: Me... 80 5e-14
UniRef50_Q83FS2 Cluster: Bifunctional protein folD [Includes: Me... 79 7e-14
UniRef50_Q8KN38 Cluster: Bifunctional protein folD [Includes: Me... 79 7e-14
UniRef50_Q5IWX9 Cluster: Plastid 5,10-methylene-tetrahydrofolate... 79 1e-13
UniRef50_A1AL91 Cluster: Bifunctional protein folD [Includes: Me... 79 1e-13
UniRef50_O83714 Cluster: Bifunctional protein folD [Includes: Me... 78 2e-13
UniRef50_Q24UZ7 Cluster: Bifunctional protein folD 2 [Includes: ... 77 5e-13
UniRef50_Q0AZF5 Cluster: Bifunctional protein folD 1 [Includes: ... 77 5e-13
UniRef50_Q54VK0 Cluster: Methenyl tetrahydrofolate cyclohydrolas... 76 6e-13
UniRef50_Q6ALZ5 Cluster: Bifunctional protein folD [Includes: Me... 76 6e-13
UniRef50_P13995 Cluster: Bifunctional methylenetetrahydrofolate ... 75 1e-12
UniRef50_Q9ZD32 Cluster: Bifunctional protein folD [Includes: Me... 75 1e-12
UniRef50_Q8EQ43 Cluster: Bifunctional protein folD [Includes: Me... 72 1e-11
UniRef50_Q4RT28 Cluster: Chromosome 12 SCAF14999, whole genome s... 71 2e-11
UniRef50_Q3YRE3 Cluster: Bifunctional protein folD [Includes: Me... 71 2e-11
UniRef50_Q1II76 Cluster: Bifunctional protein folD [Includes: Me... 71 2e-11
UniRef50_Q6F9E6 Cluster: Bifunctional protein folD 1 [Includes: ... 71 2e-11
UniRef50_Q5SJ94 Cluster: Bifunctional protein folD [Includes: Me... 71 3e-11
UniRef50_Q8DMU0 Cluster: Bifunctional protein folD [Includes: Me... 71 3e-11
UniRef50_A5CF58 Cluster: Bifunctional protein folD [Includes: Me... 71 3e-11
UniRef50_A1HML1 Cluster: Methenyltetrahydrofolate cyclohydrolase... 70 4e-11
UniRef50_Q8TK95 Cluster: Bifunctional protein folD [Includes: Me... 69 1e-10
UniRef50_Q4FNW1 Cluster: Bifunctional protein folD [Includes: Me... 69 1e-10
UniRef50_Q97HC9 Cluster: Bifunctional protein folD [Includes: Me... 69 1e-10
UniRef50_A0JTZ0 Cluster: Bifunctional protein folD [Includes: Me... 69 1e-10
UniRef50_A7D6I9 Cluster: Methenyltetrahydrofolate cyclohydrolase... 67 4e-10
UniRef50_Q6BNW9 Cluster: Debaryomyces hansenii chromosome E of s... 66 7e-10
UniRef50_Q74GN1 Cluster: Bifunctional protein folD 1 [Includes: ... 66 7e-10
UniRef50_Q4S6Y9 Cluster: Chromosome 14 SCAF14723, whole genome s... 65 2e-09
UniRef50_UPI00015B49ED Cluster: PREDICTED: similar to putative g... 64 3e-09
UniRef50_Q6D2E6 Cluster: Bifunctional protein folD [Includes: Me... 64 3e-09
UniRef50_Q189R8 Cluster: Bifunctional protein folD [Includes: Me... 64 3e-09
UniRef50_A3PVV6 Cluster: Bifunctional protein folD [Includes: Me... 64 4e-09
UniRef50_Q6F1V0 Cluster: Bifunctional protein folD [Includes: Me... 62 9e-09
UniRef50_P56467 Cluster: Bifunctional protein folD [Includes: Me... 62 9e-09
UniRef50_UPI000038C811 Cluster: COG0190: 5,10-methylene-tetrahyd... 62 1e-08
UniRef50_Q9KQQ6 Cluster: Bifunctional protein folD [Includes: Me... 61 2e-08
UniRef50_Q3AYX2 Cluster: Bifunctional protein folD [Includes: Me... 61 2e-08
UniRef50_Q5FJG5 Cluster: Bifunctional protein folD [Includes: Me... 61 2e-08
UniRef50_A7DNA7 Cluster: Methylenetetrahydrofolate dehydrogenase... 61 3e-08
UniRef50_Q14NV1 Cluster: Bifunctional protein folD [Includes: Me... 61 3e-08
UniRef50_Q6MI74 Cluster: Bifunctional protein folD [Includes: Me... 61 3e-08
UniRef50_UPI000065DF90 Cluster: methylenetetrahydrofolate dehydr... 60 3e-08
UniRef50_UPI00006CCCC6 Cluster: methylenetetrahydrofolate dehydr... 60 6e-08
UniRef50_Q3A1Q7 Cluster: Bifunctional protein folD [Includes: Me... 60 6e-08
UniRef50_Q987T6 Cluster: Bifunctional protein folD 2 [Includes: ... 59 8e-08
UniRef50_O51057 Cluster: Bifunctional protein folD [Includes: Me... 59 1e-07
UniRef50_Q8RAD0 Cluster: Bifunctional protein folD [Includes: Me... 58 1e-07
UniRef50_Q4FTX6 Cluster: Bifunctional protein folD [Includes: Me... 58 1e-07
UniRef50_A6LP88 Cluster: Tetrahydrofolate dehydrogenase/cyclohyd... 58 2e-07
UniRef50_Q74J95 Cluster: Bifunctional protein folD 1 [Includes: ... 58 2e-07
UniRef50_Q9HPY4 Cluster: Bifunctional protein folD [Includes: Me... 57 3e-07
UniRef50_Q2B9L0 Cluster: Bifunctional protein FolD; n=1; Bacillu... 57 4e-07
UniRef50_A5V1H2 Cluster: Methylenetetrahydrofolate dehydrogenase... 56 6e-07
UniRef50_A4M873 Cluster: Tetrahydrofolate dehydrogenase/cyclohyd... 56 7e-07
UniRef50_Q8ZZK1 Cluster: Bifunctional protein folD [Includes: Me... 56 7e-07
UniRef50_Q0AWX5 Cluster: Bifunctional protein folD 2 [Includes: ... 55 1e-06
UniRef50_Q0SFQ8 Cluster: Bifunctional protein folD 1 [Includes: ... 55 1e-06
UniRef50_Q8W528 Cluster: Methylenetetrahydrofolate dehydrogenase... 55 2e-06
UniRef50_Q04FB7 Cluster: Bifunctional protein folD [Includes: Me... 54 2e-06
UniRef50_Q057D7 Cluster: Bifunctional protein folD [Includes: Me... 54 2e-06
UniRef50_Q1AVQ0 Cluster: Bifunctional protein folD 2 [Includes: ... 54 2e-06
UniRef50_Q2JCX4 Cluster: Bifunctional protein folD 1 [Includes: ... 54 2e-06
UniRef50_A4EAK0 Cluster: Putative uncharacterized protein; n=3; ... 54 4e-06
UniRef50_Q8EV80 Cluster: Bifunctional protein folD [Includes: Me... 54 4e-06
UniRef50_Q86F84 Cluster: Clone ZZD1003 mRNA sequence; n=1; Schis... 53 5e-06
UniRef50_Q5RGD2 Cluster: Novel protein similar to vertebrate for... 52 9e-06
UniRef50_Q7TU81 Cluster: Bifunctional protein folD [Includes: Me... 52 9e-06
UniRef50_Q9X288 Cluster: Bifunctional protein folD [Includes: Me... 52 1e-05
UniRef50_A0DMT9 Cluster: Chromosome undetermined scaffold_57, wh... 51 2e-05
UniRef50_A0C3Q0 Cluster: Chromosome undetermined scaffold_147, w... 51 2e-05
UniRef50_P47259 Cluster: Bifunctional protein folD [Includes: Me... 51 2e-05
UniRef50_UPI0000DB7ABF Cluster: PREDICTED: similar to Bifunction... 51 3e-05
UniRef50_Q6L046 Cluster: Bifunctional protein folD [Includes: Me... 51 3e-05
UniRef50_Q8RDM4 Cluster: Bifunctional protein folD [Includes: Me... 51 3e-05
UniRef50_Q979W3 Cluster: Bifunctional protein folD [Includes: Me... 49 1e-04
UniRef50_UPI00006CB712 Cluster: tetrahydrofolate dehydrogenase/c... 46 8e-04
UniRef50_Q6KID0 Cluster: Bifunctional protein folD [Includes: Me... 44 0.003
UniRef50_Q4A6B1 Cluster: Bifunctional protein folD [Includes: Me... 43 0.006
UniRef50_Q2UUX1 Cluster: RIB40 genomic DNA, SC009; n=1; Aspergil... 41 0.022
UniRef50_Q9RW02 Cluster: Bifunctional protein folD [Includes: Me... 41 0.022
UniRef50_A7AXK7 Cluster: Putative uncharacterized protein; n=1; ... 41 0.030
UniRef50_A5IXS7 Cluster: FolD bifunctional protein; n=1; Mycopla... 41 0.030
UniRef50_Q54Z91 Cluster: Methylenetetrahydrofolate dehydrogenase... 40 0.039
UniRef50_Q8KEH0 Cluster: Methylenetetrahydrofolate dehydrogenase... 38 0.21
UniRef50_Q4QBW1 Cluster: Methylenetetrahydrofolate dehydrogenase... 38 0.21
UniRef50_Q4VDG8 Cluster: Putative methylene tetrahydrofolate deh... 38 0.28
UniRef50_Q98QV3 Cluster: Bifunctional protein folD [Includes: Me... 37 0.37
UniRef50_A6NP56 Cluster: Uncharacterized protein ENSP00000372121... 36 1.1
UniRef50_UPI0000D9D4E1 Cluster: PREDICTED: similar to Bifunction... 35 1.5
UniRef50_Q4DH06 Cluster: Methylenetetrahydrofolate dehydrogenase... 34 2.6
UniRef50_Q5KEZ0 Cluster: Methylenetetrahydrofolate dehydrogenase... 34 2.6
UniRef50_Q89QU6 Cluster: Bll3028 protein; n=6; Proteobacteria|Re... 33 6.0
UniRef50_A6FY71 Cluster: Histone deacetylase superfamily protein... 33 7.9
>UniRef50_Q9XYB0 Cluster: PugilistDominant; n=2; Coelomata|Rep:
PugilistDominant - Drosophila melanogaster (Fruit fly)
Length = 268
Score = 142 bits (343), Expect = 9e-33
Identities = 62/87 (71%), Positives = 75/87 (86%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L R ITE+ELL KI LNE P VHGIIVQMPLD D ID+HR+TDAVSP+KDVDGL+T+N
Sbjct: 72 LPRSITEVELLDKINDLNEDPRVHGIIVQMPLDCDTPIDSHRITDAVSPEKDVDGLHTVN 131
Query: 428 EGRVAVGDLSGFIPCTPAGCVELIKKT 508
EGR+A+GDL GF+PCTP GC+ELI+++
Sbjct: 132 EGRLAIGDLGGFLPCTPWGCLELIRRS 158
Score = 87.0 bits (206), Expect = 3e-16
Identities = 43/70 (61%), Positives = 53/70 (75%)
Frame = +3
Query: 45 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 224
A+IISG VA SI +LR +VT + + + F P L IVQVGGREDSNVYIRMK+KAA +I
Sbjct: 4 AKIISGTAVAKSIREELRNEVTAMSKQLADFVPGLRIVQVGGREDSNVYIRMKIKAATEI 63
Query: 225 GIAAEHIRLP 254
GI A H++LP
Sbjct: 64 GIDAAHVQLP 73
Score = 34.3 bits (75), Expect = 2.6
Identities = 16/22 (72%), Positives = 17/22 (77%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVS 576
V IAG VVLGRS+IVGTP S
Sbjct: 160 VEIAGARAVVLGRSKIVGTPAS 181
>UniRef50_UPI00015B59A5 Cluster: PREDICTED: similar to
ENSANGP00000016878; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000016878 - Nasonia
vitripennis
Length = 866
Score = 133 bits (321), Expect = 4e-30
Identities = 58/82 (70%), Positives = 69/82 (84%)
Frame = +2
Query: 263 TEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVA 442
TE ELL K+ LN P HGIIVQMPLDS + I++H +TD VSPDKDVDGLNTINEGRVA
Sbjct: 80 TEHELLTKLNKLNNDPDTHGIIVQMPLDSVNKINSHLITDTVSPDKDVDGLNTINEGRVA 139
Query: 443 VGDLSGFIPCTPAGCVELIKKT 508
+GD+SGF+PCTP GC+ELIK++
Sbjct: 140 IGDMSGFLPCTPNGCIELIKRS 161
Score = 82.6 bits (195), Expect = 7e-15
Identities = 37/71 (52%), Positives = 51/71 (71%)
Frame = +3
Query: 51 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGI 230
++SG ++A I L + V ++ K + P LAIVQVGGREDSNVYIRMK+KAA +IGI
Sbjct: 9 VLSGTDLAKEIRESLAKDVAAIQQKLPNYAPGLAIVQVGGREDSNVYIRMKIKAASEIGI 68
Query: 231 AAEHIRLPGTS 263
A H+++P T+
Sbjct: 69 KATHVKMPNTT 79
Score = 71.7 bits (168), Expect = 1e-11
Identities = 32/45 (71%), Positives = 38/45 (84%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEI 645
V IAG VVLGRS+IVGTPV+ELLKW +ATVTVCHS+TK+L +
Sbjct: 163 VPIAGAQAVVLGRSKIVGTPVAELLKWHNATVTVCHSRTKDLPSV 207
>UniRef50_P11586 Cluster: C-1-tetrahydrofolate synthase, cytoplasmic
(C1-THF synthase) [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate
synthetase (EC 6.3.4.3)]; n=86; cellular organisms|Rep:
C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF
synthase) [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate
synthetase (EC 6.3.4.3)] - Homo sapiens (Human)
Length = 935
Score = 110 bits (265), Expect = 2e-23
Identities = 51/88 (57%), Positives = 69/88 (78%), Gaps = 1/88 (1%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L R TE E++ ITSLNE +VHG +VQ+PLDS+++I+ V +A++P+KDVDGL +IN
Sbjct: 72 LPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKDVDGLTSIN 131
Query: 428 EGRVAVGDLSG-FIPCTPAGCVELIKKT 508
GR+A GDL+ FIPCTP GC+ELIK+T
Sbjct: 132 AGRLARGDLNDCFIPCTPKGCLELIKET 159
Score = 88.2 bits (209), Expect = 1e-16
Identities = 41/73 (56%), Positives = 57/73 (78%)
Frame = +3
Query: 45 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 224
A+I++G E++ I L+ QVT+L+ + GF PRLAI+QVG R+DSN+YI +KLKAAE+I
Sbjct: 4 AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63
Query: 225 GIAAEHIRLPGTS 263
GI A HI+LP T+
Sbjct: 64 GIKATHIKLPRTT 76
Score = 63.3 bits (147), Expect = 5e-09
Identities = 28/47 (59%), Positives = 36/47 (76%)
Frame = +1
Query: 502 EDRVTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSE 642
E V IAG++ VV+GRS+IVG P+ +LL W +ATVT CHSKT +L E
Sbjct: 158 ETGVPIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTAHLDE 204
>UniRef50_Q4T2B9 Cluster: Chromosome undetermined SCAF10300, whole
genome shotgun sequence; n=6; Clupeocephala|Rep:
Chromosome undetermined SCAF10300, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 348
Score = 106 bits (255), Expect = 4e-22
Identities = 50/88 (56%), Positives = 66/88 (75%), Gaps = 1/88 (1%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L T+ E+L I S+NE SVHG+IVQ+PLDS H ID+ +T+ VS DKDVDGL+ IN
Sbjct: 118 LPSSATQEEVLLNILSINEDQSVHGLIVQLPLDSVHHIDSECITNTVSADKDVDGLSCIN 177
Query: 428 EGRVAVGDLSG-FIPCTPAGCVELIKKT 508
GR++ GDL F+PCTP+GC+ELI++T
Sbjct: 178 AGRLSRGDLDACFLPCTPSGCLELIRQT 205
Score = 64.1 bits (149), Expect = 3e-09
Identities = 27/44 (61%), Positives = 34/44 (77%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSE 642
V++ GK VV+GRS+IVG P+ +LL W HATVT CHSKT +L E
Sbjct: 207 VSLEGKQAVVIGRSKIVGAPMHDLLLWNHATVTTCHSKTPDLPE 250
Score = 51.6 bits (118), Expect = 2e-05
Identities = 27/57 (47%), Positives = 40/57 (70%)
Frame = +3
Query: 93 LRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPGTS 263
L Q++ RL S F + ++QVG R+DSN+YI K+KAA +IGI A+H+RLP ++
Sbjct: 68 LGQKLLRLLVLTSVF--LVTLLQVGDRDDSNLYISAKMKAAAEIGIDAKHVRLPSSA 122
>UniRef50_O84081 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Chlamydiaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Chlamydia trachomatis
Length = 287
Score = 90.6 bits (215), Expect = 3e-17
Identities = 41/89 (46%), Positives = 59/89 (66%)
Frame = +2
Query: 236 RTYPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGL 415
++Y D T ++LA I LN ++HGI+VQ+PL +DA + ++PDKDVDGL
Sbjct: 59 KSYRKPSDATLSDILALIHQLNNDENIHGILVQLPLPKH--LDAQAILSTITPDKDVDGL 116
Query: 416 NTINEGRVAVGDLSGFIPCTPAGCVELIK 502
+ +N G++ +G+ GFIPCTPAG VEL K
Sbjct: 117 HPVNVGKLLLGETDGFIPCTPAGIVELCK 145
Score = 48.4 bits (110), Expect = 1e-04
Identities = 24/50 (48%), Positives = 37/50 (74%), Gaps = 4/50 (8%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWEH----ATVTVCHSKTKNLSEIT 648
+ + GK+VV+LGRS IVG P++ LL H A+VT+ HS++++L+EIT
Sbjct: 149 IPLHGKHVVILGRSNIVGKPLAALLMQRHADTNASVTLLHSQSEHLTEIT 198
Score = 35.5 bits (78), Expect = 1.1
Identities = 14/38 (36%), Positives = 23/38 (60%)
Frame = +3
Query: 141 PRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLP 254
P LA+V +G S +Y+ MK+K A +G+ ++ R P
Sbjct: 27 PGLAVVLIGNNPASEIYVNMKIKRATDLGMVSKSYRKP 64
>UniRef50_Q5PBL6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Alphaproteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Anaplasma marginale (strain St. Maries)
Length = 299
Score = 89.8 bits (213), Expect = 5e-17
Identities = 44/89 (49%), Positives = 56/89 (62%)
Frame = +2
Query: 236 RTYPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGL 415
RT L D ++ ELL I LN +VHGI+VQ+PL ID V +A+SP+KDVDG
Sbjct: 65 RTIALEHDTSQEELLRIIDELNRDAAVHGILVQLPLPRH--IDKELVINAISPEKDVDGF 122
Query: 416 NTINEGRVAVGDLSGFIPCTPAGCVELIK 502
+ N G++A G L IPCTP GC+ LIK
Sbjct: 123 HNANAGKLATGQLDCMIPCTPQGCIHLIK 151
Score = 54.0 bits (124), Expect = 3e-06
Identities = 25/42 (59%), Positives = 32/42 (76%)
Frame = +1
Query: 517 IAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSE 642
+AG N VV+GRS IVG PV+ LL +E+ TVTV HS ++NL E
Sbjct: 157 LAGSNAVVVGRSNIVGKPVALLLLYENCTVTVLHSASRNLEE 198
>UniRef50_Q21285 Cluster: Dauer or aging adult overexpression
protein 3; n=2; Caenorhabditis|Rep: Dauer or aging adult
overexpression protein 3 - Caenorhabditis elegans
Length = 303
Score = 84.2 bits (199), Expect = 2e-15
Identities = 41/83 (49%), Positives = 55/83 (66%), Gaps = 1/83 (1%)
Frame = +2
Query: 260 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 439
IT+ +L +I +LN + GII+Q+PLD H IDA V D + P KDVDGL IN GR+
Sbjct: 75 ITQGDLKREIMALNHDNEIDGIIIQLPLDCKHEIDADSVIDLIDPLKDVDGLTRINAGRL 134
Query: 440 AVGDLSGFI-PCTPAGCVELIKK 505
A G+L I PCTP GC+ L+++
Sbjct: 135 ARGELQRTIFPCTPFGCLYLVQQ 157
Score = 68.1 bits (159), Expect = 2e-10
Identities = 33/73 (45%), Positives = 48/73 (65%)
Frame = +3
Query: 42 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEK 221
+A+I+SG+E + + +D+ Q++ + R F LAIVQVG R DSNVYI KLK A++
Sbjct: 2 VAEIVSGLEYSKKVLHDVGQKIAKTREHHPNFHAVLAIVQVGNRSDSNVYINSKLKKAKE 61
Query: 222 IGIAAEHIRLPGT 260
IG + I+LP T
Sbjct: 62 IGADGKLIKLPDT 74
Score = 65.7 bits (153), Expect = 9e-10
Identities = 27/42 (64%), Positives = 33/42 (78%)
Frame = +1
Query: 517 IAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSE 642
++GK VVVLGRS+IVG+P + L W H TVT+CHSKT NL E
Sbjct: 165 VSGKEVVVLGRSKIVGSPAAALFLWHHGTVTICHSKTPNLKE 206
>UniRef50_O65271 Cluster: F6N23.26 protein; n=20; Viridiplantae|Rep:
F6N23.26 protein - Arabidopsis thaliana (Mouse-ear
cress)
Length = 360
Score = 83.8 bits (198), Expect = 3e-15
Identities = 40/87 (45%), Positives = 59/87 (67%), Gaps = 1/87 (1%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L D +E E+L ++ N+ PSVHGI+VQ+PL S +D + +AVS +KDVDG + +N
Sbjct: 136 LAEDSSEEEVLKSVSGFNDDPSVHGILVQLPLPSH--MDEQNILNAVSIEKDVDGFHPLN 193
Query: 428 EGRVAV-GDLSGFIPCTPAGCVELIKK 505
GR+A+ G F+PCTP GC+EL+ +
Sbjct: 194 IGRLAMRGREPLFVPCTPKGCIELLHR 220
Score = 54.8 bits (126), Expect = 2e-06
Identities = 26/46 (56%), Positives = 33/46 (71%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEIT 648
+ I GK VV+GRS IVG P + LL+ E ATV++ HS+TKN EIT
Sbjct: 223 IEIKGKRAVVIGRSNIVGMPAALLLQREDATVSIIHSRTKNPEEIT 268
Score = 50.4 bits (115), Expect = 4e-05
Identities = 26/69 (37%), Positives = 42/69 (60%)
Frame = +3
Query: 45 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 224
A +I G VA I +++ +V+R++ G P LA++ VG R+DS Y+R K KA + +
Sbjct: 69 AIVIDGKAVAKKIRDEITIEVSRMKES-IGVIPGLAVILVGDRKDSATYVRNKKKACDSV 127
Query: 225 GIAAEHIRL 251
GI + +RL
Sbjct: 128 GIKSFEVRL 136
>UniRef50_Q7MVE9 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=52; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Porphyromonas gingivalis (Bacteroides gingivalis)
Length = 296
Score = 83.0 bits (196), Expect = 6e-15
Identities = 41/83 (49%), Positives = 57/83 (68%)
Frame = +2
Query: 257 DITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGR 436
D+TE ELLA + LN+ P+V G IVQ+PL ID ++ +AV P KDVDG + IN GR
Sbjct: 75 DVTEEELLACVHRLNQDPTVDGFIVQLPLPKH--IDEQKIIEAVDPRKDVDGFHPINVGR 132
Query: 437 VAVGDLSGFIPCTPAGCVELIKK 505
+++G L GF+ TP G VEL+++
Sbjct: 133 LSIG-LPGFVSATPKGIVELLRR 154
Score = 50.8 bits (116), Expect = 3e-05
Identities = 26/45 (57%), Positives = 33/45 (73%), Gaps = 4/45 (8%)
Frame = +1
Query: 523 GKNVVVLGRSRIVGTPVSELL--KWE--HATVTVCHSKTKNLSEI 645
GK+ VVLGRS IVG PVS+LL K E T+T+CHS+T N+ E+
Sbjct: 161 GKHCVVLGRSNIVGKPVSQLLLQKGEPGDCTITICHSRTPNIKEV 205
>UniRef50_Q9LHH7 Cluster: 5,10-methylenetetrahydrofolate
dehydrogenase/5,10- methenyltetrahydrofolate
cyclohydrolase; n=7; Eukaryota|Rep:
5,10-methylenetetrahydrofolate dehydrogenase/5,10-
methenyltetrahydrofolate cyclohydrolase - Arabidopsis
thaliana (Mouse-ear cress)
Length = 299
Score = 81.4 bits (192), Expect = 2e-14
Identities = 38/88 (43%), Positives = 61/88 (69%), Gaps = 1/88 (1%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L +++E +L++K+ LN +P VHGI+VQ+PL H + H + A+S DKDVDG + +N
Sbjct: 76 LPEEVSEADLISKVHELNSNPDVHGILVQLPLPK-HINEEH-ILGAISIDKDVDGFHPLN 133
Query: 428 EGRVAV-GDLSGFIPCTPAGCVELIKKT 508
G++A+ G F+PCTP GC+EL+ ++
Sbjct: 134 IGKLAMKGREPLFLPCTPKGCLELLARS 161
Score = 50.8 bits (116), Expect = 3e-05
Identities = 27/70 (38%), Positives = 42/70 (60%)
Frame = +3
Query: 45 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 224
A+II G +A +I +++ ++V L K G P LA+V VG R+DS Y+ K KA ++
Sbjct: 9 AKIIDGKAIAHTIRSEIAEEVRGLSEK-HGKVPGLAVVIVGSRKDSQTYVNTKRKACAEV 67
Query: 225 GIAAEHIRLP 254
GI + + LP
Sbjct: 68 GIKSFDVGLP 77
Score = 45.2 bits (102), Expect = 0.001
Identities = 24/41 (58%), Positives = 27/41 (65%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKN 633
V I G+ VV+GRS IVG PVS LL ATVT HS TK+
Sbjct: 163 VKIKGQRAVVVGRSNIVGLPVSLLLLKADATVTTVHSHTKD 203
>UniRef50_O65269 Cluster: F6N23.28 protein; n=1; Arabidopsis
thaliana|Rep: F6N23.28 protein - Arabidopsis thaliana
(Mouse-ear cress)
Length = 310
Score = 81.0 bits (191), Expect = 2e-14
Identities = 38/84 (45%), Positives = 58/84 (69%), Gaps = 1/84 (1%)
Frame = +2
Query: 257 DITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGR 436
D +E E+L ++ N+ PSVHG++VQ+PL S +D + +AVS +KDVDG + +N GR
Sbjct: 89 DSSEEEVLKYVSGFNDDPSVHGVLVQLPLPSH--MDEQNILNAVSIEKDVDGFHPLNIGR 146
Query: 437 VAV-GDLSGFIPCTPAGCVELIKK 505
+A+ G F+PCTP GC+EL+ +
Sbjct: 147 LAMRGREPLFVPCTPKGCIELLHR 170
Score = 50.0 bits (114), Expect = 5e-05
Identities = 23/46 (50%), Positives = 31/46 (67%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEIT 648
+ GK VV+GRS IVG P + LL+ E ATV++ HS+T N E+T
Sbjct: 173 IEFKGKRAVVIGRSNIVGMPAALLLQKEDATVSIIHSRTMNPEELT 218
>UniRef50_Q16F77 Cluster: Methylenetetrahydrofolate dehydrogenase;
n=4; cellular organisms|Rep: Methylenetetrahydrofolate
dehydrogenase - Aedes aegypti (Yellowfever mosquito)
Length = 337
Score = 80.2 bits (189), Expect = 4e-14
Identities = 43/91 (47%), Positives = 60/91 (65%)
Frame = +2
Query: 236 RTYPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGL 415
+T + DITE +LL +I LN+ SV GI+VQ+P+ I+ +V ++VS DKDVDG
Sbjct: 97 KTERYSADITEEQLLKRIEELNQDDSVDGILVQLPVPGH--INERKVCNSVSCDKDVDGF 154
Query: 416 NTINEGRVAVGDLSGFIPCTPAGCVELIKKT 508
N N GR+ + D++ IPCTP G ELIK+T
Sbjct: 155 NERNIGRLCL-DMNTLIPCTPLGVQELIKRT 184
Score = 46.8 bits (106), Expect = 5e-04
Identities = 21/67 (31%), Positives = 37/67 (55%)
Frame = +3
Query: 39 KMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAE 218
+MA++I G ++A I +LR+Q+ + P L + +G SN Y+ K+KAA
Sbjct: 31 EMAKLIDGKQIAADIRMELREQIEEWMKQGGNRAPHLTAILIGEDPASNTYVSNKMKAAA 90
Query: 219 KIGIAAE 239
+GI ++
Sbjct: 91 DVGITSK 97
Score = 34.3 bits (75), Expect = 2.6
Identities = 20/43 (46%), Positives = 26/43 (60%), Gaps = 8/43 (18%)
Frame = +1
Query: 523 GKNVVVLGRSRIVGTPVSELLKWE--------HATVTVCHSKT 627
GKN VV+GRS+ VG P++ LL + ATVT+CH T
Sbjct: 190 GKNAVVVGRSKNVGMPIAMLLHADGRNDTCAMDATVTMCHRFT 232
>UniRef50_Q9A8Y0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=82; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Caulobacter crescentus (Caulobacter
vibrioides)
Length = 297
Score = 79.8 bits (188), Expect = 5e-14
Identities = 41/88 (46%), Positives = 52/88 (59%)
Frame = +2
Query: 239 TYPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLN 418
T+ L T+ ELLA + LN P +HG++VQ P+ I V A+SPDKDVDGL
Sbjct: 68 THRLPETTTQDELLAVVAKLNADPKIHGVLVQFPVPPH--ISQMDVVAALSPDKDVDGLT 125
Query: 419 TINEGRVAVGDLSGFIPCTPAGCVELIK 502
N GR+A G L PCTP GC+ LI+
Sbjct: 126 VTNAGRLASG-LPALAPCTPTGCMMLIR 152
Score = 42.7 bits (96), Expect = 0.007
Identities = 17/43 (39%), Positives = 30/43 (69%)
Frame = +1
Query: 517 IAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEI 645
+ GK VV+GRS ++G P++++L TVT+ HS++++L I
Sbjct: 158 LKGKTAVVIGRSNLMGKPMAQMLLAADCTVTIAHSRSQDLPSI 200
Score = 39.9 bits (89), Expect = 0.052
Identities = 24/73 (32%), Positives = 39/73 (53%)
Frame = +3
Query: 45 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 224
A++I G A + + ++V L+++ G P LA+V VG S VY+R K +
Sbjct: 4 AKLIDGKAFAADLRAKIAEEVAALKAE-HGVTPGLAVVLVGEDPASQVYVRNKGEQTTAA 62
Query: 225 GIAAEHIRLPGTS 263
G+ +E RLP T+
Sbjct: 63 GMYSETHRLPETT 75
>UniRef50_Q63SL6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=226; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Burkholderia pseudomallei (Pseudomonas
pseudomallei)
Length = 285
Score = 79.8 bits (188), Expect = 5e-14
Identities = 39/87 (44%), Positives = 58/87 (66%)
Frame = +2
Query: 242 YPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 421
YP T ++E ELLA+I LN P +HGI+VQ+PL + ID+H+V +A++P+KDVDG +
Sbjct: 69 YPAT--LSEPELLARIDELNRDPKIHGILVQLPLPAH--IDSHKVIEAIAPEKDVDGFHV 124
Query: 422 INEGRVAVGDLSGFIPCTPAGCVELIK 502
N G + G F PCTP G +++ +
Sbjct: 125 ANAGALLTGK-PLFRPCTPYGVMKMFE 150
Score = 52.4 bits (120), Expect = 9e-06
Identities = 24/47 (51%), Positives = 33/47 (70%)
Frame = +1
Query: 508 RVTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEIT 648
++ + G N VV+GRS IVG P++ LL ATVT+CHSKT+ L+ T
Sbjct: 153 KIPLQGANAVVIGRSNIVGKPMALLLLEAGATVTICHSKTRELAAHT 199
Score = 38.3 bits (85), Expect = 0.16
Identities = 22/72 (30%), Positives = 36/72 (50%)
Frame = +3
Query: 45 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 224
A +I G ++ ++ ++ L ++ G P LA++ VG S VY+R K+KA E
Sbjct: 3 ATLIDGNALSKTLRAQAAERAAALAAR--GHRPGLAVILVGDNPASEVYVRNKIKACEDN 60
Query: 225 GIAAEHIRLPGT 260
G + R P T
Sbjct: 61 GFFSLKDRYPAT 72
>UniRef50_Q83FS2 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Tropheryma whipplei|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Tropheryma whipplei (strain Twist)
(Whipple's bacillus)
Length = 295
Score = 79.4 bits (187), Expect = 7e-14
Identities = 39/85 (45%), Positives = 58/85 (68%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L + +E EL++K+ LN S V GIIVQ+PL +ID ++V +A++PDKD DGL+ +N
Sbjct: 69 LPANTSEKELISKVEILNASSDVSGIIVQLPLPE--SIDQNKVIEAINPDKDADGLHPLN 126
Query: 428 EGRVAVGDLSGFIPCTPAGCVELIK 502
G + G G +PCTPAG V+L++
Sbjct: 127 LGYLVTGK-QGIVPCTPAGIVKLLE 150
Score = 41.1 bits (92), Expect = 0.022
Identities = 20/49 (40%), Positives = 32/49 (65%), Gaps = 2/49 (4%)
Frame = +1
Query: 508 RVTIAGKNVVVLGRSRIVGTPVSELL--KWEHATVTVCHSKTKNLSEIT 648
R+T+ GK + V+GR VG P+ LL K +ATV HS+++N+S ++
Sbjct: 153 RITLEGKTIAVIGRGTTVGRPLGILLSGKGVNATVINIHSRSRNISGLS 201
Score = 36.7 bits (81), Expect = 0.48
Identities = 22/74 (29%), Positives = 37/74 (50%)
Frame = +3
Query: 42 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEK 221
+A+++ G+ V+ I L + L + +G P+LA V VG S Y+ K + +
Sbjct: 2 VAKVLDGLAVSAGIFERLHRACCELEN--NGVCPKLATVLVGNNPASRSYVLSKHRDCKN 59
Query: 222 IGIAAEHIRLPGTS 263
IGI + I LP +
Sbjct: 60 IGIQSTLIELPANT 73
>UniRef50_Q8KN38 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Sphingobium chlorophenolicum|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Sphingobium
chlorophenolicum
Length = 316
Score = 79.4 bits (187), Expect = 7e-14
Identities = 39/85 (45%), Positives = 55/85 (64%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L D +E +LLA I SLN VHGI+VQ+PL + ID+ +V D + P KDVDG + +N
Sbjct: 69 LPADCSEEDLLALIASLNADERVHGILVQLPLPAQ--IDSGKVLDTIDPRKDVDGFHPVN 126
Query: 428 EGRVAVGDLSGFIPCTPAGCVELIK 502
R++ G G +PCTP GC+ L++
Sbjct: 127 VFRLSTG-TGGLVPCTPMGCMILLR 150
Score = 48.8 bits (111), Expect = 1e-04
Identities = 27/71 (38%), Positives = 39/71 (54%)
Frame = +3
Query: 42 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEK 221
MA IISG A + DL + V R S+ G+ P L V VG S++Y+R K++ K
Sbjct: 1 MASIISGTAAAEGLLADLTRDVARF-SQVHGYAPTLVAVLVGDDPASHIYVRKKIEQCRK 59
Query: 222 IGIAAEHIRLP 254
+G+ + RLP
Sbjct: 60 VGMESVEHRLP 70
Score = 48.0 bits (109), Expect = 2e-04
Identities = 22/43 (51%), Positives = 30/43 (69%)
Frame = +1
Query: 517 IAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEI 645
+ GK VV+G+S IVG PV+ LL + TVTVC T+NL+E+
Sbjct: 156 LKGKQAVVIGKSNIVGKPVAMLLLEQGCTVTVCGRHTRNLAEV 198
>UniRef50_Q5IWX9 Cluster: Plastid 5,10-methylene-tetrahydrofolate
dehydrogenase; n=1; Prototheca wickerhamii|Rep: Plastid
5,10-methylene-tetrahydrofolate dehydrogenase -
Prototheca wickerhamii
Length = 248
Score = 78.6 bits (185), Expect = 1e-13
Identities = 40/87 (45%), Positives = 58/87 (66%), Gaps = 1/87 (1%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L TE E+LA + N+ P+VHGI+VQ+PL +H I+ RV DA+S +KDVDG + N
Sbjct: 129 LPETATEEEVLAVVAKFNDDPNVHGILVQLPL-PEH-INEKRVLDAISLEKDVDGFHPNN 186
Query: 428 EGRVAV-GDLSGFIPCTPAGCVELIKK 505
G +A+ G ++ CTP GC+EL+K+
Sbjct: 187 IGELAMRGRSPTYVSCTPKGCLELLKR 213
Score = 54.8 bits (126), Expect = 2e-06
Identities = 31/86 (36%), Positives = 51/86 (59%)
Frame = +3
Query: 6 SARANETVLWAKMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSN 185
SA+ A A +I G ++A +I +L+ +V LR++++ P LA+V VG R+DS
Sbjct: 49 SAKRAVATASAMPAALIDGKKIAETIRGELKVEVDELRAQYNTV-PGLAVVLVGERKDSQ 107
Query: 186 VYIRMKLKAAEKIGIAAEHIRLPGTS 263
Y+R K KA +++GI + LP T+
Sbjct: 108 TYVRSKKKACDEVGINSFGADLPETA 133
Score = 41.5 bits (93), Expect = 0.017
Identities = 20/33 (60%), Positives = 24/33 (72%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWEHATVT 609
VT+AGK V+GRS IVG P + LL+ E ATVT
Sbjct: 216 VTLAGKRAAVVGRSNIVGLPAALLLQQEDATVT 248
>UniRef50_A1AL91 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=9; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Pelobacter propionicus (strain DSM 2379)
Length = 283
Score = 78.6 bits (185), Expect = 1e-13
Identities = 39/88 (44%), Positives = 57/88 (64%)
Frame = +2
Query: 242 YPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 421
+ L + +E ELLA + LN P +HGI+VQ+PL S ID +V +A+SP KDVDG +
Sbjct: 66 HKLAAETSEAELLALVELLNNDPKIHGILVQLPLPSQ--IDTDKVLEAISPFKDVDGFHP 123
Query: 422 INEGRVAVGDLSGFIPCTPAGCVELIKK 505
N GR++VG F PCTP G + ++++
Sbjct: 124 YNVGRLSVGK-PVFQPCTPYGVMVMLRE 150
Score = 58.0 bits (134), Expect = 2e-07
Identities = 26/48 (54%), Positives = 36/48 (75%)
Frame = +1
Query: 502 EDRVTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEI 645
E V + GK VVV+GRS IVG PV+ + EHATVT+CHS+T++L ++
Sbjct: 150 EAGVELKGKEVVVVGRSNIVGKPVAMMCLAEHATVTLCHSRTRDLPDV 197
>UniRef50_O83714 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Treponema pallidum
Length = 315
Score = 77.8 bits (183), Expect = 2e-13
Identities = 39/92 (42%), Positives = 58/92 (63%)
Frame = +2
Query: 230 RRRTYPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVD 409
R T+ L + ++L I LNE VHGI++Q+PL + +DA RV AV+P+KDVD
Sbjct: 64 RGETHRLPAHASHAQVLELIARLNEDARVHGILIQLPLPAH--LDAARVCRAVAPEKDVD 121
Query: 410 GLNTINEGRVAVGDLSGFIPCTPAGCVELIKK 505
G + +N G + + GF+PCTPAG V L+++
Sbjct: 122 GFHPLNCGALFLAQ-PGFVPCTPAGIVHLLRR 152
Score = 47.2 bits (107), Expect = 3e-04
Identities = 24/48 (50%), Positives = 34/48 (70%), Gaps = 2/48 (4%)
Frame = +1
Query: 508 RVTIAGKNVVVLGRSRIVGTPVSELLKWE--HATVTVCHSKTKNLSEI 645
+V +AG VV++GRS IVG P++ LL ATVT+CHS T+ L++I
Sbjct: 154 QVPLAGARVVIVGRSAIVGRPLAVLLASPGCDATVTLCHSHTRGLADI 201
>UniRef50_Q24UZ7 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Peptococcaceae|Rep: Bifunctional protein folD 2
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Desulfitobacterium hafniense (strain Y51)
Length = 284
Score = 76.6 bits (180), Expect = 5e-13
Identities = 38/87 (43%), Positives = 54/87 (62%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L D +E +LA I SLN +P VHGI++++PL I RV AV PDKDVDG++ IN
Sbjct: 68 LPADSSEESILALIDSLNANPDVHGIMIELPLPKH--ISKERVMAAVRPDKDVDGVHPIN 125
Query: 428 EGRVAVGDLSGFIPCTPAGCVELIKKT 508
G + G+ G P TP C+E++ ++
Sbjct: 126 RGYILSGE-EGLFPATPESCIEIMLRS 151
Score = 50.8 bits (116), Expect = 3e-05
Identities = 23/46 (50%), Positives = 32/46 (69%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEIT 648
V IAGK+VV++GR VG P+ L+ +ATVT+CHS+T +L T
Sbjct: 153 VEIAGKHVVIVGRGETVGKPLVFLILKHNATVTICHSRTPDLGAFT 198
Score = 48.0 bits (109), Expect = 2e-04
Identities = 25/74 (33%), Positives = 44/74 (59%)
Frame = +3
Query: 42 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEK 221
MAQ++ G E++ ++ +++++V R + + G P+LA+V VG S VY + K K ++
Sbjct: 1 MAQLLDGKEISKVLKEEIKEEVKRWKEQ--GVNPKLAVVLVGDDPASVVYAKSKQKVSDS 58
Query: 222 IGIAAEHIRLPGTS 263
+GI E LP S
Sbjct: 59 LGIDFELTVLPADS 72
>UniRef50_Q0AZF5 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Syntrophomonas wolfei subsp. wolfei str.
Goettingen|Rep: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Syntrophomonas wolfei subsp. wolfei (strain Goettingen)
Length = 277
Score = 76.6 bits (180), Expect = 5e-13
Identities = 36/92 (39%), Positives = 55/92 (59%)
Frame = +2
Query: 230 RRRTYPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVD 409
+ R L D ++ EL+AKI LN+ V GI++Q+PL + + A+ PDKDVD
Sbjct: 58 KSRLLHLPEDTSQQELMAKIAELNQDEQVDGILLQLPLPAALEEQTDEILAAIRPDKDVD 117
Query: 410 GLNTINEGRVAVGDLSGFIPCTPAGCVELIKK 505
G + +N GR++ GD GFI C C+E+I++
Sbjct: 118 GFSLVNRGRMS-GDRPGFISCAALACLEVIER 148
Score = 39.1 bits (87), Expect = 0.091
Identities = 23/69 (33%), Positives = 38/69 (55%)
Frame = +3
Query: 48 QIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIG 227
+IISG ++A I L+++ R G P LA++ VGG+++ Y+ +K KAA G
Sbjct: 2 EIISGSQIAQEIRQKLKEKNER-----EGISPCLAMILVGGQKEDLHYVGLKEKAATATG 56
Query: 228 IAAEHIRLP 254
+ + LP
Sbjct: 57 GKSRLLHLP 65
>UniRef50_Q54VK0 Cluster: Methenyl tetrahydrofolate cyclohydrolase /
NADP-dependent methylene H4F dehydrogenase; n=1;
Dictyostelium discoideum AX4|Rep: Methenyl
tetrahydrofolate cyclohydrolase / NADP-dependent
methylene H4F dehydrogenase - Dictyostelium discoideum
AX4
Length = 440
Score = 76.2 bits (179), Expect = 6e-13
Identities = 37/82 (45%), Positives = 53/82 (64%)
Frame = +2
Query: 257 DITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGR 436
DI E +L+ KI +E PSVHGIIVQ+PL + DA + ++ P KDVDGL + N G+
Sbjct: 156 DIKEDQLIKKIKYHSEDPSVHGIIVQLPLPDNLNKDA--IIQSIDPKKDVDGLTSTNLGQ 213
Query: 437 VAVGDLSGFIPCTPAGCVELIK 502
+ + +IPCTP G +E++K
Sbjct: 214 IMISKKPLYIPCTPLGILEILK 235
Score = 35.1 bits (77), Expect = 1.5
Identities = 19/51 (37%), Positives = 29/51 (56%), Gaps = 9/51 (17%)
Frame = +1
Query: 508 RVTIAGKNVVVLGRSRIVGTPVSELLKWEH---------ATVTVCHSKTKN 633
++ + GKNVVVLGRS +VG ++ +L + A VT+ H +KN
Sbjct: 238 KIKVEGKNVVVLGRSNLVGRTIATILSQKDLTNPSIMNGANVTIIHKYSKN 288
>UniRef50_Q6ALZ5 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=27; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Desulfotalea psychrophila
Length = 296
Score = 76.2 bits (179), Expect = 6e-13
Identities = 37/88 (42%), Positives = 55/88 (62%), Gaps = 1/88 (1%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L+ + TE ELLA I N S+HG++VQ+PL I+ + A+ PDKDVD + +N
Sbjct: 70 LSVETTEAELLALIEKYNNDDSIHGVLVQLPLPKH--INEQNIITAIDPDKDVDAFHPVN 127
Query: 428 EGRVAV-GDLSGFIPCTPAGCVELIKKT 508
GR+ + GD F+PCTPAG E++ ++
Sbjct: 128 IGRLMIGGDDVKFLPCTPAGIQEMLVRS 155
Score = 37.5 bits (83), Expect = 0.28
Identities = 19/47 (40%), Positives = 32/47 (68%), Gaps = 4/47 (8%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWE----HATVTVCHSKTKNLS 639
V AG VVV+GRS IVG P++ ++ + +ATVT+ H+ +++L+
Sbjct: 157 VETAGAEVVVVGRSNIVGKPIAMMMAQKGIGANATVTIVHTGSRDLA 203
>UniRef50_P13995 Cluster: Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor
[Includes: NAD-dependent methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)]; n=66; cellular
organisms|Rep: Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor
[Includes: NAD-dependent methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Homo sapiens (Human)
Length = 350
Score = 75.4 bits (177), Expect = 1e-12
Identities = 41/83 (49%), Positives = 55/83 (66%)
Frame = +2
Query: 260 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 439
I+E ELL I LN +V G++VQ+PL +H ID R+ +AVSPDKDVDG + IN GR+
Sbjct: 108 ISEEELLNLINKLNNDDNVDGLLVQLPLP-EH-IDERRICNAVSPDKDVDGFHVINVGRM 165
Query: 440 AVGDLSGFIPCTPAGCVELIKKT 508
+ D +P TP G E+IK+T
Sbjct: 166 CL-DQYSMLPATPWGVWEIIKRT 187
Score = 40.3 bits (90), Expect = 0.039
Identities = 23/72 (31%), Positives = 40/72 (55%)
Frame = +3
Query: 45 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 224
A +ISG ++A I+ ++RQ+V + P L+++ VG S+ Y+ K +AA +
Sbjct: 37 AVVISGRKLAQQIKQEVRQEVEEWVAS-GNKRPHLSVILVGENPASHSYVLNKTRAAAVV 95
Query: 225 GIAAEHIRLPGT 260
GI +E I P +
Sbjct: 96 GINSETIMKPAS 107
Score = 32.7 bits (71), Expect = 7.9
Identities = 20/43 (46%), Positives = 25/43 (58%), Gaps = 8/43 (18%)
Frame = +1
Query: 523 GKNVVVLGRSRIVGTPVSELLKWE--------HATVTVCHSKT 627
GKNVVV GRS+ VG P++ LL + ATVT+ H T
Sbjct: 193 GKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYT 235
>UniRef50_Q9ZD32 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Rickettsia|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rickettsia prowazekii
Length = 286
Score = 74.9 bits (176), Expect = 1e-12
Identities = 39/88 (44%), Positives = 54/88 (61%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L+ +I +L+ KI LN + GIIVQ+PL S +ID +++ AV P KD DG + +N
Sbjct: 70 LSTNIYTDDLILKINELNLDKGISGIIVQLPLPS--SIDENKILSAVLPSKDSDGFHPLN 127
Query: 428 EGRVAVGDLSGFIPCTPAGCVELIKKTA 511
G + G GFIPCT GC+ +IKK A
Sbjct: 128 VGYLHSGINQGFIPCTALGCLAVIKKYA 155
Score = 57.6 bits (133), Expect = 2e-07
Identities = 26/42 (61%), Positives = 33/42 (78%)
Frame = +1
Query: 523 GKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEIT 648
GK+ V++GRS IVG P+S LL E+ +VT+CHSKT NLS IT
Sbjct: 160 GKDAVIVGRSNIVGKPLSALLLQENCSVTICHSKTCNLSSIT 201
Score = 40.7 bits (91), Expect = 0.030
Identities = 22/60 (36%), Positives = 35/60 (58%)
Frame = +3
Query: 51 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGI 230
II G +A I DL+ ++ + K + P+LAIV VG S +Y++ K+K A ++GI
Sbjct: 5 IIDGKALANEILADLKLEIQGFKEK-TKTSPKLAIVLVGDNPASMIYVKNKIKNAHQVGI 63
>UniRef50_Q8EQ43 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=45; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Oceanobacillus iheyensis
Length = 285
Score = 72.1 bits (169), Expect = 1e-11
Identities = 36/85 (42%), Positives = 53/85 (62%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L +I++ ELL I N SVHGI+VQ+PL +D ++ A+SP KDVDG + IN
Sbjct: 68 LPENISQDELLQIIDEQNNDDSVHGILVQLPLPDQ--MDEQKIIHAISPAKDVDGFHPIN 125
Query: 428 EGRVAVGDLSGFIPCTPAGCVELIK 502
G++ G+ FIPCTP G + +++
Sbjct: 126 VGKMMTGE-DTFIPCTPYGILTMLR 149
Score = 58.4 bits (135), Expect = 1e-07
Identities = 26/46 (56%), Positives = 35/46 (76%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEIT 648
+++ GK+ V++GRS IVG P+ LL E+ATVT HS+TKNL EIT
Sbjct: 153 ISLEGKHAVIIGRSNIVGKPIGLLLLQENATVTYTHSRTKNLQEIT 198
>UniRef50_Q4RT28 Cluster: Chromosome 12 SCAF14999, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 12 SCAF14999, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 342
Score = 71.3 bits (167), Expect = 2e-11
Identities = 39/84 (46%), Positives = 54/84 (64%)
Frame = +2
Query: 257 DITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGR 436
DI+E ELL I LN V G++VQ+PL +H ID + +AV+P KDVDG + +N GR
Sbjct: 100 DISEEELLDLIDKLNTDHRVDGLLVQLPLP-EH-IDERTICNAVAPTKDVDGFHVVNVGR 157
Query: 437 VAVGDLSGFIPCTPAGCVELIKKT 508
+ + D S +P TP G E+IK+T
Sbjct: 158 MCL-DQSSMLPATPWGVWEIIKRT 180
Score = 32.7 bits (71), Expect = 7.9
Identities = 20/43 (46%), Positives = 25/43 (58%), Gaps = 8/43 (18%)
Frame = +1
Query: 523 GKNVVVLGRSRIVGTPVSELLKWE--------HATVTVCHSKT 627
GKNVVV GRS+ VG P++ LL + ATVT+ H T
Sbjct: 186 GKNVVVAGRSKNVGMPIAMLLHTDGRHERPGGDATVTISHRYT 228
>UniRef50_Q3YRE3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Proteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Ehrlichia canis (strain Jake)
Length = 300
Score = 70.9 bits (166), Expect = 2e-11
Identities = 38/92 (41%), Positives = 51/92 (55%), Gaps = 1/92 (1%)
Frame = +2
Query: 230 RRRTYPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVD 409
R T L +E L+ KI LN +VHGI+VQ+P+ ID + + + + P KDVD
Sbjct: 64 RSETILLPSTTSESSLIDKIHELNNDDNVHGILVQLPVPKH--IDKNLIINTIDPRKDVD 121
Query: 410 GLNTINEGRVAVGDLSG-FIPCTPAGCVELIK 502
G + N GR+ G IPCTP GC+ LIK
Sbjct: 122 GFHNDNVGRLFTGQKRNCLIPCTPRGCLYLIK 153
Score = 48.4 bits (110), Expect = 1e-04
Identities = 22/42 (52%), Positives = 31/42 (73%)
Frame = +1
Query: 517 IAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSE 642
++G + VV+GRS IVG P++ LL E+ TVT HS T+NLS+
Sbjct: 159 LSGSDAVVIGRSNIVGKPMACLLLGENCTVTTVHSATRNLSD 200
Score = 44.0 bits (99), Expect = 0.003
Identities = 26/73 (35%), Positives = 41/73 (56%)
Frame = +3
Query: 45 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 224
A II+G +A I L + L+ ++S P L +V VG S++Y+R K + AE +
Sbjct: 3 ANIINGKAIAEDITGTLATCINDLKLQYS-LVPCLIVVLVGDDPASHLYVRNKQRKAEML 61
Query: 225 GIAAEHIRLPGTS 263
G+ +E I LP T+
Sbjct: 62 GLRSETILLPSTT 74
>UniRef50_Q1II76 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Acidobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Acidobacteria bacterium (strain Ellin345)
Length = 307
Score = 70.9 bits (166), Expect = 2e-11
Identities = 32/83 (38%), Positives = 55/83 (66%)
Frame = +2
Query: 260 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 439
++ +LL + SLN + GI+VQ+PL +D+ ++ AVSP+KDVDG + +N G +
Sbjct: 73 VSTADLLQLVESLNRRNDIDGILVQLPLPKQ--VDSKKILLAVSPEKDVDGFHPMNVGYL 130
Query: 440 AVGDLSGFIPCTPAGCVELIKKT 508
+ G +PCTPAGC+E+++++
Sbjct: 131 STVR-PGLVPCTPAGCMEILRRS 152
Score = 50.4 bits (115), Expect = 4e-05
Identities = 23/45 (51%), Positives = 32/45 (71%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEI 645
V + G + VV+GRS IVG P++ LL +ATVT+CHSKT +L +
Sbjct: 154 VPVEGADAVVVGRSDIVGKPIAMLLTNANATVTICHSKTHDLPAV 198
>UniRef50_Q6F9E6 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Proteobacteria|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Acinetobacter sp. (strain ADP1)
Length = 297
Score = 70.9 bits (166), Expect = 2e-11
Identities = 36/82 (43%), Positives = 50/82 (60%)
Frame = +2
Query: 257 DITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGR 436
D++E ELL +I LN VHGI+VQ+PL I+ RV + + P KDVDG ++ N G
Sbjct: 80 DLSEDELLTQIDRLNTERGVHGILVQLPLPKQ--INETRVLERIHPQKDVDGFHSENVGG 137
Query: 437 VAVGDLSGFIPCTPAGCVELIK 502
++ G PCTP GC+ L+K
Sbjct: 138 LSQG-RDVLTPCTPTGCIRLLK 158
Score = 50.4 bits (115), Expect = 4e-05
Identities = 22/43 (51%), Positives = 32/43 (74%)
Frame = +1
Query: 517 IAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEI 645
++G + VV+GRS IVG P++ LL E TVTV HSKT+N+ ++
Sbjct: 165 LSGLHAVVIGRSNIVGKPMAALLLKESCTVTVVHSKTRNIEQV 207
Score = 42.7 bits (96), Expect = 0.007
Identities = 24/67 (35%), Positives = 40/67 (59%)
Frame = +3
Query: 48 QIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIG 227
+II G +A S+ +++ +V R +++ G EP LA+V VG S VY+R K++ A +G
Sbjct: 12 KIIDGKAIAQSVLEEVKLEVERYKAQ--GIEPCLAVVLVGEDPASQVYVRNKVQKAAFVG 69
Query: 228 IAAEHIR 248
I + R
Sbjct: 70 IRSLEFR 76
>UniRef50_Q5SJ94 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermus thermophilus|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermus thermophilus (strain HB8 / ATCC
27634 / DSM 579)
Length = 282
Score = 70.5 bits (165), Expect = 3e-11
Identities = 39/92 (42%), Positives = 51/92 (55%)
Frame = +2
Query: 227 YRRRTYPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDV 406
YR + D+ E LL +I +LN V GI+VQ+PL I RV +A+ P KDV
Sbjct: 59 YRSQVEVYPEDLPEEALLERIAALNADEEVDGILVQLPLPPH--IRTQRVLEAIHPLKDV 116
Query: 407 DGLNTINEGRVAVGDLSGFIPCTPAGCVELIK 502
DG + +N GR+ G G PCTP G V L+K
Sbjct: 117 DGFHPLNVGRLWSGG-KGLFPCTPLGVVRLLK 147
Score = 56.0 bits (129), Expect = 7e-07
Identities = 27/46 (58%), Positives = 35/46 (76%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEIT 648
V + GK VVV+GRS IVG P++ LL E ATVT+ HSKT++L E+T
Sbjct: 151 VDLRGKEVVVVGRSNIVGKPLAGLLLREDATVTLAHSKTQDLPEVT 196
Score = 37.5 bits (83), Expect = 0.28
Identities = 22/65 (33%), Positives = 37/65 (56%)
Frame = +3
Query: 45 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 224
AQ++SG E A ++ ++R RLRS F P L ++++G S Y+R+K K A +
Sbjct: 3 AQVLSGHEAAEAVYEEIR---ARLRSL--SFTPSLRVIRLGEDPASVAYVRLKDKRARAL 57
Query: 225 GIAAE 239
G ++
Sbjct: 58 GYRSQ 62
>UniRef50_Q8DMU0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=90; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Synechococcus elongatus (Thermosynechococcus
elongatus)
Length = 306
Score = 70.5 bits (165), Expect = 3e-11
Identities = 40/84 (47%), Positives = 52/84 (61%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L ITE LLAKIT LN+ V GI++Q+PL +D + A+ PDKDVDGL+ N
Sbjct: 73 LPATITEAALLAKITELNQDERVDGILLQLPLPPH--LDPRPLLYAIHPDKDVDGLHPEN 130
Query: 428 EGRVAVGDLSGFIPCTPAGCVELI 499
GR+ V D G CTPAG ++L+
Sbjct: 131 LGRL-VRDEPGLRSCTPAGVMQLL 153
Score = 48.8 bits (111), Expect = 1e-04
Identities = 27/75 (36%), Positives = 40/75 (53%)
Frame = +3
Query: 36 AKMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAA 215
A A + G +A SIE L V +++W G P LA+++VG S VY+R K +A
Sbjct: 3 AHAATCLDGKSLAQSIERQLADHVRTFQAQW-GRSPGLAVLRVGNDPASAVYVRAKEQAC 61
Query: 216 EKIGIAAEHIRLPGT 260
++GI + LP T
Sbjct: 62 SRVGIQSFGAHLPAT 76
Score = 46.4 bits (105), Expect = 6e-04
Identities = 19/46 (41%), Positives = 34/46 (73%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEIT 648
+ + G++ VV+GRS +VG P++ +L +ATVT+ HS+++ L+ IT
Sbjct: 158 IDVVGRSAVVVGRSILVGKPLALMLLSANATVTIAHSRSRELASIT 203
>UniRef50_A5CF58 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Orientia tsutsugamushi Boryong|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Orientia tsutsugamushi
(strain Boryong) (Rickettsia tsutsugamushi)
Length = 301
Score = 70.5 bits (165), Expect = 3e-11
Identities = 37/81 (45%), Positives = 50/81 (61%)
Frame = +2
Query: 260 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 439
I E +L + I LN +VHGIIVQ+PL IDA ++ + KDVDGLN IN G +
Sbjct: 73 IEEKKLFSVIDDLNCDSTVHGIIVQLPLPPH--IDALKLFARIDSRKDVDGLNPINIGYL 130
Query: 440 AVGDLSGFIPCTPAGCVELIK 502
+G G IPCT GC++L++
Sbjct: 131 NIGANQGLIPCTALGCIDLLQ 151
Score = 48.8 bits (111), Expect = 1e-04
Identities = 22/41 (53%), Positives = 30/41 (73%)
Frame = +1
Query: 517 IAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLS 639
+ GK+VVV+G+S IVG P+S LL TVT+CHS T +L+
Sbjct: 157 LKGKHVVVIGKSNIVGKPLSALLLRNSCTVTICHSATVDLA 197
Score = 32.7 bits (71), Expect = 7.9
Identities = 20/70 (28%), Positives = 37/70 (52%)
Frame = +3
Query: 42 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEK 221
M I+ G ++A + + + L+ K+ +L I+ VG + S +Y+ K+ A+
Sbjct: 1 MTVIMDGKKLAELRLIETKNDLLALKDKYQ-ITVKLVIILVGNNDASLIYVNNKVAKAKA 59
Query: 222 IGIAAEHIRL 251
IG+ +E IRL
Sbjct: 60 IGMDSEIIRL 69
>UniRef50_A1HML1 Cluster: Methenyltetrahydrofolate cyclohydrolase;
n=1; Thermosinus carboxydivorans Nor1|Rep:
Methenyltetrahydrofolate cyclohydrolase - Thermosinus
carboxydivorans Nor1
Length = 279
Score = 70.1 bits (164), Expect = 4e-11
Identities = 38/84 (45%), Positives = 50/84 (59%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L D TE E+LA + LNE +HGI+ MPL A D RV A++PDKDVD L+ +N
Sbjct: 68 LPADATEEEVLALVCELNEDDHIHGILPMMPLPPHLATD--RVAAALAPDKDVDALHPLN 125
Query: 428 EGRVAVGDLSGFIPCTPAGCVELI 499
G VA G S + PCTP + ++
Sbjct: 126 AGLVATGK-SRWAPCTPRAVMAIL 148
Score = 60.1 bits (139), Expect = 5e-08
Identities = 24/47 (51%), Positives = 39/47 (82%)
Frame = +1
Query: 508 RVTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEIT 648
++ ++GK+ VV+GRS +VG P++ LL ++ATVTVCHSKT++L+ +T
Sbjct: 152 QIDVSGKHAVVIGRSNVVGKPLAHLLLGQNATVTVCHSKTRDLAALT 198
>UniRef50_Q8TK95 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Methanosarcina acetivorans
Length = 290
Score = 68.9 bits (161), Expect = 1e-10
Identities = 33/89 (37%), Positives = 52/89 (58%), Gaps = 1/89 (1%)
Frame = +2
Query: 242 YPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHA-IDAHRVTDAVSPDKDVDGLN 418
Y L D T+ ELL I SLN++ VH I++Q+PL + + +A+SP KD DG +
Sbjct: 73 YLLPGDATQEELLTLIDSLNKNKDVHAILLQLPLPKHFSPQETQEAMEAISPTKDADGFH 132
Query: 419 TINEGRVAVGDLSGFIPCTPAGCVELIKK 505
N G++ +GD +PCTP G + +++
Sbjct: 133 PYNMGKLMIGD-EDLVPCTPHGVIRALEE 160
Score = 51.2 bits (117), Expect = 2e-05
Identities = 28/71 (39%), Positives = 41/71 (57%)
Frame = +3
Query: 45 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 224
++II G +A +E ++R V L S G P LA + VG S +Y+R+K +A E++
Sbjct: 8 SRIIDGKVLAQQVEEEVRSGVEDLESN-RGIVPGLATILVGDDPASKMYVRLKHRACERV 66
Query: 225 GIAAEHIRLPG 257
GI AE LPG
Sbjct: 67 GIKAEDYLLPG 77
Score = 47.6 bits (108), Expect = 3e-04
Identities = 23/57 (40%), Positives = 37/57 (64%)
Frame = +1
Query: 478 GRVRGTD*EDRVTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEIT 648
G +R + E V++ GKN V++G S +VG P++ +L +ATV+VCH T +L + T
Sbjct: 153 GVIRALE-EYGVSVQGKNAVIVGHSNVVGKPMAAMLLNRNATVSVCHIFTDDLKKYT 208
>UniRef50_Q4FNW1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Pelagibacter ubique
Length = 281
Score = 68.5 bits (160), Expect = 1e-10
Identities = 35/82 (42%), Positives = 50/82 (60%)
Frame = +2
Query: 260 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 439
+ E +L KI LN+ S+ GI+VQ+PL ID +V + + P KDVDG + +N G +
Sbjct: 72 VEEKTVLDKIEELNKDESISGILVQLPLPKH--IDKQKVIETILPGKDVDGFHPMNVGNL 129
Query: 440 AVGDLSGFIPCTPAGCVELIKK 505
+ G S +PCTP GC +IKK
Sbjct: 130 SSGYESS-VPCTPLGCYLMIKK 150
Score = 54.4 bits (125), Expect = 2e-06
Identities = 25/68 (36%), Positives = 42/68 (61%)
Frame = +3
Query: 51 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGI 230
+I G ++A + LRQ+V L++K + P L ++ +G S +Y+RMK KAA ++G+
Sbjct: 3 LIDGKKIAAELREQLRQEVVELKAKHNKI-PGLTVILIGEMAPSQIYVRMKEKAANEVGL 61
Query: 231 AAEHIRLP 254
+E IR P
Sbjct: 62 KSEVIRYP 69
Score = 47.6 bits (108), Expect = 3e-04
Identities = 20/40 (50%), Positives = 31/40 (77%)
Frame = +1
Query: 517 IAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNL 636
++GK V++GRS + G P+++LL E+ TVT+ HSKTK+L
Sbjct: 155 LSGKKAVMIGRSNLNGKPMAQLLLKENCTVTITHSKTKDL 194
>UniRef50_Q97HC9 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; Clostridium|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Clostridium acetobutylicum
Length = 278
Score = 68.5 bits (160), Expect = 1e-10
Identities = 37/85 (43%), Positives = 49/85 (57%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L I E EL+ I LN +HGI++Q+PL + IDA VT + +KD+D L IN
Sbjct: 69 LDESIREEELIKLIEGLNVDNKIHGIMLQLPLPNH--IDAKLVTSKIDANKDIDSLTDIN 126
Query: 428 EGRVAVGDLSGFIPCTPAGCVELIK 502
G+ G+ S FIPCTP + LIK
Sbjct: 127 TGKFYKGEKS-FIPCTPRSIINLIK 150
Score = 62.9 bits (146), Expect = 6e-09
Identities = 28/45 (62%), Positives = 36/45 (80%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEI 645
V I GKN VV+GRS IVG P ++LL E+ATVT+CHS+T+NL +I
Sbjct: 154 VDICGKNAVVIGRSNIVGKPTAQLLLNENATVTICHSRTQNLKDI 198
>UniRef50_A0JTZ0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=51; Actinobacteria (class)|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Arthrobacter sp. (strain FB24)
Length = 302
Score = 68.5 bits (160), Expect = 1e-10
Identities = 33/89 (37%), Positives = 53/89 (59%), Gaps = 3/89 (3%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L D T+ ++ A I LN P+ HG IVQ+PL +D + + + P KD DGL+ N
Sbjct: 71 LPADATQAQVEALIDELNADPACHGYIVQLPLPKH--LDTDAILERIDPAKDADGLHPTN 128
Query: 428 EGRVAV---GDLSGFIPCTPAGCVELIKK 505
GR+ + G+++ +PCTP G +EL+++
Sbjct: 129 LGRLVLNVSGEITSPLPCTPRGVIELLER 157
Score = 38.3 bits (85), Expect = 0.16
Identities = 19/46 (41%), Positives = 33/46 (71%), Gaps = 2/46 (4%)
Frame = +1
Query: 514 TIAGKNVVVLGRSRIVGTPVSELL--KWEHATVTVCHSKTKNLSEI 645
+++GK+VVV+GR +G + LL + +ATVT+ H+ T+NLS++
Sbjct: 161 SLSGKHVVVVGRGVTIGRTIGLLLTRRSVNATVTLTHTGTENLSQL 206
>UniRef50_A7D6I9 Cluster: Methenyltetrahydrofolate cyclohydrolase;
n=1; Halorubrum lacusprofundi ATCC 49239|Rep:
Methenyltetrahydrofolate cyclohydrolase - Halorubrum
lacusprofundi ATCC 49239
Length = 307
Score = 66.9 bits (156), Expect = 4e-10
Identities = 36/76 (47%), Positives = 47/76 (61%)
Frame = +2
Query: 272 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVAVGD 451
EL I LNE VHGI+VQ+P+ DH +D RV ++P KDVDG + N GR+ GD
Sbjct: 86 ELYETIDDLNEREDVHGILVQLPVP-DH-VDKRRVLRQIAPVKDVDGFHPENVGRLVAGD 143
Query: 452 LSGFIPCTPAGCVELI 499
+ F PCTP G +L+
Sbjct: 144 -ARFKPCTPHGVQKLL 158
Score = 41.1 bits (92), Expect = 0.022
Identities = 22/46 (47%), Positives = 31/46 (67%), Gaps = 4/46 (8%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWE----HATVTVCHSKTKNL 636
V G + VV+GRS IVG P++ LL + +AT TVCHS+T++L
Sbjct: 163 VETEGADAVVVGRSDIVGKPMANLLIQKGPIGNATTTVCHSRTRDL 208
>UniRef50_Q6BNW9 Cluster: Debaryomyces hansenii chromosome E of
strain CBS767 of Debaryomyces hansenii; n=2;
Debaryomyces hansenii|Rep: Debaryomyces hansenii
chromosome E of strain CBS767 of Debaryomyces hansenii -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 276
Score = 66.1 bits (154), Expect = 7e-10
Identities = 35/85 (41%), Positives = 52/85 (61%), Gaps = 1/85 (1%)
Frame = +2
Query: 257 DITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGR 436
D++E +LL +I LN+ P V+G+++Q+PL + +T+AV+ +KDVDG N G
Sbjct: 115 DMSEEDLLEEIDRLNKDPKVNGLLIQLPLPKH--FNETLITNAVATEKDVDGFARYNVGE 172
Query: 437 VAV-GDLSGFIPCTPAGCVELIKKT 508
+ G F PCTP G +ELIK T
Sbjct: 173 LTKKGGAPMFKPCTPNGIMELIKTT 197
Score = 55.2 bits (127), Expect = 1e-06
Identities = 24/45 (53%), Positives = 33/45 (73%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEI 645
+++ GKN VVLGRS IVGTPV+ +L+ E TVT+CH T +L +
Sbjct: 199 ISLRGKNAVVLGRSDIVGTPVAAMLRNEDCTVTICHRHTYDLPSV 243
Score = 43.2 bits (97), Expect = 0.006
Identities = 18/38 (47%), Positives = 26/38 (68%)
Frame = +3
Query: 135 FEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIR 248
F P L I+QVGGR DS+ Y++ KLKAA+ I + ++
Sbjct: 74 FRPNLTIIQVGGRPDSSAYVKAKLKAAKSSNILSSLLK 111
>UniRef50_Q74GN1 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Bacteria|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Geobacter sulfurreducens
Length = 290
Score = 66.1 bits (154), Expect = 7e-10
Identities = 34/81 (41%), Positives = 50/81 (61%)
Frame = +2
Query: 260 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 439
I E ELLAKI +NE P+ G+IVQ+PL I+ V +A++P+KD+DG + N GR+
Sbjct: 72 IRESELLAKIKEVNEDPTTDGLIVQLPLPKH--INQQHVINAIAPEKDIDGFHPANFGRM 129
Query: 440 AVGDLSGFIPCTPAGCVELIK 502
+G F P T G +L++
Sbjct: 130 TLGQ-KAFRPATAYGICKLLQ 149
Score = 35.1 bits (77), Expect = 1.5
Identities = 19/43 (44%), Positives = 28/43 (65%), Gaps = 4/43 (9%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWE----HATVTVCHSKT 627
V + K+ VV+GRS IVG P+S +L + +ATVT+ H +T
Sbjct: 153 VPVKAKHCVVIGRSNIVGKPISIMLSNDFDIGNATVTLTHIET 195
>UniRef50_Q4S6Y9 Cluster: Chromosome 14 SCAF14723, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 14 SCAF14723, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 1066
Score = 64.9 bits (151), Expect = 2e-09
Identities = 33/87 (37%), Positives = 53/87 (60%), Gaps = 1/87 (1%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L ++ +EIE++ ++ L+E P VHG+ + +P A RV A+ P+KDVDGL+ +N
Sbjct: 56 LAKECSEIEIVTEVLKLSEDPGVHGLYLHLP----QASLTSRVLTALKPEKDVDGLSDLN 111
Query: 428 EGRVAVGDLS-GFIPCTPAGCVELIKK 505
G + GDLS GF+P + +E + K
Sbjct: 112 TGCLIRGDLSAGFVPPVTSAVLEWLSK 138
>UniRef50_UPI00015B49ED Cluster: PREDICTED: similar to putative
glyoxylate reductase/hydroxypyruvate reductase; n=1;
Nasonia vitripennis|Rep: PREDICTED: similar to putative
glyoxylate reductase/hydroxypyruvate reductase - Nasonia
vitripennis
Length = 699
Score = 64.1 bits (149), Expect = 3e-09
Identities = 35/83 (42%), Positives = 52/83 (62%)
Frame = +2
Query: 260 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 439
IT+ ELL ++ LN+ P+V G++VQ+P+ +H I V AV+P KDVDG + N G +
Sbjct: 99 ITQEELLHEVQKLNDDPTVDGLLVQLPV-PEH-ISEREVCQAVTPTKDVDGFHLSNIGNL 156
Query: 440 AVGDLSGFIPCTPAGCVELIKKT 508
A+ + G IP T G ELI ++
Sbjct: 157 ALNN-KGIIPATALGVKELIVRS 178
Score = 38.3 bits (85), Expect = 0.16
Identities = 21/68 (30%), Positives = 35/68 (51%)
Frame = +3
Query: 45 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 224
A II G VA + +++ +V + P+L + VG S Y+ K+KAA+ +
Sbjct: 28 AAIIDGNGVADQVLEEVKAEVDEMTRNGEK-RPKLIAILVGNNPASKAYVGRKVKAAKTV 86
Query: 225 GIAAEHIR 248
GI +E +R
Sbjct: 87 GIESETLR 94
>UniRef50_Q6D2E6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Erwinia carotovora subsp. atroseptica (Pectobacterium
atrosepticum)
Length = 287
Score = 64.1 bits (149), Expect = 3e-09
Identities = 36/90 (40%), Positives = 51/90 (56%)
Frame = +2
Query: 236 RTYPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGL 415
R+Y L TE ELLA I LN ++ GI+VQ+PL ID +V + ++PDKDVDG
Sbjct: 66 RSYDLPITTTESELLALIDQLNADQAIDGILVQLPL--PEGIDNTKVIERIAPDKDVDGF 123
Query: 416 NTINEGRVAVGDLSGFIPCTPAGCVELIKK 505
+ N GR+ CTP G + L+++
Sbjct: 124 HPYNVGRLC-QRAPLLRACTPRGIITLLER 152
Score = 36.7 bits (81), Expect = 0.48
Identities = 20/38 (52%), Positives = 22/38 (57%)
Frame = +1
Query: 523 GKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNL 636
G N VV+G S IVG P+S L T TV H TKNL
Sbjct: 159 GLNAVVVGASNIVGRPMSLELLLAGCTTTVTHRFTKNL 196
>UniRef50_Q189R8 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=11; Clostridiales|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Clostridium difficile (strain 630)
Length = 290
Score = 64.1 bits (149), Expect = 3e-09
Identities = 30/45 (66%), Positives = 34/45 (75%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEI 645
V + G V VLGRS +VG PVS LL EHATVT+CHSKTKNLS +
Sbjct: 160 VDLKGSKVTVLGRSMVVGKPVSMLLLSEHATVTICHSKTKNLSGV 204
Score = 63.3 bits (147), Expect = 5e-09
Identities = 31/85 (36%), Positives = 49/85 (57%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L DIT+ E + + +N+ +V+GI+ PL ++ + ++P+KDVD + IN
Sbjct: 74 LAEDITQEEYIDVLKRVNDDKNVNGILCFRPLPKH--LNEEVIKYVIAPEKDVDCFSPIN 131
Query: 428 EGRVAVGDLSGFIPCTPAGCVELIK 502
+V GD SGF PCTP VE++K
Sbjct: 132 SAKVMEGDKSGFPPCTPTAVVEILK 156
Score = 45.6 bits (103), Expect = 0.001
Identities = 28/68 (41%), Positives = 36/68 (52%)
Frame = +3
Query: 48 QIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIG 227
QII G VA I +L ++V L + G P+L IV+VG R D Y R LK + IG
Sbjct: 9 QIIKGKPVADKISEELIKEVDLLVKE--GINPKLTIVRVGARSDDLSYERGALKRCQNIG 66
Query: 228 IAAEHIRL 251
I E + L
Sbjct: 67 ITTEVLEL 74
>UniRef50_A3PVV6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; Actinobacteridae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycobacterium sp. (strain JLS)
Length = 288
Score = 63.7 bits (148), Expect = 4e-09
Identities = 33/86 (38%), Positives = 50/86 (58%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L DI++ EL A I LN +P G IVQ+PL +D + + + P KD DGL+ N
Sbjct: 72 LPADISQAELDATIDELNANPECTGYIVQLPLPKH--LDENAALERIDPGKDADGLHPTN 129
Query: 428 EGRVAVGDLSGFIPCTPAGCVELIKK 505
GR+ + + + +PCTP G V L+++
Sbjct: 130 LGRLVLNEPAP-LPCTPRGIVHLLRR 154
Score = 46.8 bits (106), Expect = 5e-04
Identities = 24/48 (50%), Positives = 34/48 (70%), Gaps = 2/48 (4%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELL--KWEHATVTVCHSKTKNLSEIT 648
V IAG +VVV+GR VG P+ LL + E+ATVT+CH+ T++L + T
Sbjct: 157 VEIAGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTATRHLPQFT 204
>UniRef50_Q6F1V0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Mollicutes|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mesoplasma florum (Acholeplasma florum)
Length = 286
Score = 62.5 bits (145), Expect = 9e-09
Identities = 31/84 (36%), Positives = 50/84 (59%)
Frame = +2
Query: 254 RDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEG 433
+DI + EL KI LN ++ GI++Q+PL D + + A++P KDVDG + IN+G
Sbjct: 70 KDIKKEELYNKINELNNDQNIDGILLQLPLPIDFIEEDY--LQAITPSKDVDGFHYINQG 127
Query: 434 RVAVGDLSGFIPCTPAGCVELIKK 505
++ G PCTP G + L+++
Sbjct: 128 KMLQG-YDTVYPCTPLGIINLLEE 150
Score = 42.7 bits (96), Expect = 0.007
Identities = 17/49 (34%), Positives = 30/49 (61%)
Frame = +1
Query: 502 EDRVTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEIT 648
E +++ K++ ++G S IVG P+ +L AT+T+C+ TKN+ T
Sbjct: 150 EYNISVKNKDITLIGTSNIVGKPLGMMLLNNQATITMCNKNTKNIKNHT 198
Score = 41.1 bits (92), Expect = 0.022
Identities = 20/66 (30%), Positives = 39/66 (59%)
Frame = +3
Query: 51 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGI 230
I+ G +VA + +L ++++ +K +P+L ++ VG S VY+ K+K A ++GI
Sbjct: 3 ILDGKKVASRRKEELTAKISKYHNKGLR-KPKLVVIMVGNDPASEVYVSHKIKVANEVGI 61
Query: 231 AAEHIR 248
+E +R
Sbjct: 62 YSELLR 67
>UniRef50_P56467 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Helicobacter pylori (Campylobacter pylori)
Length = 290
Score = 62.5 bits (145), Expect = 9e-09
Identities = 30/85 (35%), Positives = 50/85 (58%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L +ITE +LL+ I N ++ G++VQ+PL ID + +A+ P+KDVDG + +N
Sbjct: 73 LQENITEAKLLSLIKDYNTDQNISGVLVQLPLPRH--IDTKMILEAIDPNKDVDGFHPLN 130
Query: 428 EGRVAVGDLSGFIPCTPAGCVELIK 502
G++ F+P TP G + L++
Sbjct: 131 IGKLCT-QKESFLPATPMGVMRLLE 154
Score = 44.0 bits (99), Expect = 0.003
Identities = 20/46 (43%), Positives = 31/46 (67%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEIT 648
+ I GK+V ++G S I+G P+S L+ A+V+VCH TK++S T
Sbjct: 158 IEIKGKDVAIIGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYT 203
Score = 41.5 bits (93), Expect = 0.017
Identities = 19/60 (31%), Positives = 38/60 (63%)
Frame = +3
Query: 51 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGI 230
++ G +A +IE DL+ ++ + ++ + P+LA++ VG S Y+ MK+KA E++G+
Sbjct: 8 LLDGQALADNIEKDLKHKIQIITAQ-THKRPKLAVILVGKDPASITYVNMKIKACERVGM 66
>UniRef50_UPI000038C811 Cluster: COG0190:
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl
tetrahydrofolate cyclohydrolase; n=1; Nostoc punctiforme
PCC 73102|Rep: COG0190: 5,10-methylene-tetrahydrofolate
dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase -
Nostoc punctiforme PCC 73102
Length = 292
Score = 62.1 bits (144), Expect = 1e-08
Identities = 33/78 (42%), Positives = 49/78 (62%)
Frame = +2
Query: 272 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVAVGD 451
EL I +LN+ V GI+VQ+PL DH +DA + + PDKD DGL+ +N GR+ G+
Sbjct: 81 ELEKVIAALNDDERVDGILVQLPLP-DH-LDAVALLHQIDPDKDADGLHPVNLGRLVRGE 138
Query: 452 LSGFIPCTPAGCVELIKK 505
+ G CTP G + L+++
Sbjct: 139 I-GLRSCTPDGVMRLLQE 155
Score = 46.0 bits (104), Expect = 8e-04
Identities = 24/66 (36%), Positives = 39/66 (59%)
Frame = +3
Query: 39 KMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAE 218
K A+++ G +A I+ +L +T+L+ + G P LA++ VG S Y+R K KA
Sbjct: 4 KTAKLLDGKAIAAKIQQELSVAITQLQPE-IGRPPGLAVLMVGDNPASAAYVRNKEKACA 62
Query: 219 KIGIAA 236
K+GIA+
Sbjct: 63 KVGIAS 68
Score = 45.2 bits (102), Expect = 0.001
Identities = 21/49 (42%), Positives = 32/49 (65%)
Frame = +1
Query: 502 EDRVTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEIT 648
E + + GK VV+GRS +VG P++ +L ATVT+ HS++ +L IT
Sbjct: 155 EYEIPLQGKQAVVVGRSILVGKPMALMLLEADATVTIAHSRSHDLKSIT 203
>UniRef50_Q9KQQ6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=44; Gammaproteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Vibrio cholerae
Length = 286
Score = 61.3 bits (142), Expect = 2e-08
Identities = 30/90 (33%), Positives = 53/90 (58%)
Frame = +2
Query: 236 RTYPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGL 415
+++ L +E LL+ + LN P + GI+VQ+PL + +D +V +++ P+KDVDG
Sbjct: 66 KSFDLPATASEEALLSLVEELNNDPQIDGILVQLPLPA--GMDTTKVLESIHPEKDVDGF 123
Query: 416 NTINEGRVAVGDLSGFIPCTPAGCVELIKK 505
+ N GR+A + CTP G + L+++
Sbjct: 124 HPYNVGRLA-QRIPKLRSCTPKGIITLLER 152
Score = 37.9 bits (84), Expect = 0.21
Identities = 22/73 (30%), Positives = 40/73 (54%)
Frame = +3
Query: 45 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 224
AQ I G ++ ++ +++ +V + R + P LA+V VG S VY+ K +A E++
Sbjct: 3 AQNIDGTLISQTVRSEVAARV-KARVQAGLRAPGLAVVLVGEDPASQVYVGSKRRACEEV 61
Query: 225 GIAAEHIRLPGTS 263
G ++ LP T+
Sbjct: 62 GFVSKSFDLPATA 74
Score = 35.9 bits (79), Expect = 0.84
Identities = 16/42 (38%), Positives = 25/42 (59%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNL 636
+ + GK+ V++G S IVG P++ L T T CH T++L
Sbjct: 155 IPLRGKHAVIVGASNIVGRPMTLELLLAGCTTTTCHRFTQDL 196
>UniRef50_Q3AYX2 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=36; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Synechococcus sp. (strain CC9902)
Length = 293
Score = 61.3 bits (142), Expect = 2e-08
Identities = 31/77 (40%), Positives = 48/77 (62%)
Frame = +2
Query: 272 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVAVGD 451
E+L+ I LN P V GI++Q+PL +D + A+ P+KD DGL+T+N GR+ G+
Sbjct: 77 EVLSTIQQLNADPRVDGILLQLPLPE--GLDEGPLLMAIDPEKDADGLHTLNLGRLLKGE 134
Query: 452 LSGFIPCTPAGCVELIK 502
G CTPAG + +++
Sbjct: 135 -QGPRSCTPAGVMAMLR 150
Score = 46.0 bits (104), Expect = 8e-04
Identities = 21/39 (53%), Positives = 31/39 (79%)
Frame = +1
Query: 520 AGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNL 636
AG+ VV+GRS +VG P++ +L+ +ATVTV HS+TK+L
Sbjct: 157 AGQRAVVIGRSILVGQPMALMLQAANATVTVVHSRTKDL 195
Score = 39.9 bits (89), Expect = 0.052
Identities = 24/74 (32%), Positives = 42/74 (56%)
Frame = +3
Query: 42 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEK 221
MA + G +A ++E+ L+ Q+ + +G P LA+++VG S VY+ K KA +
Sbjct: 1 MALRLDGKALAKAVESRLQAQIESNLPQ-AGRPPGLAVLRVGDDPASAVYVANKEKACAR 59
Query: 222 IGIAAEHIRLPGTS 263
IG+A+ LP ++
Sbjct: 60 IGVASYGAHLPSST 73
>UniRef50_Q5FJG5 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Firmicutes|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Lactobacillus acidophilus
Length = 283
Score = 61.3 bits (142), Expect = 2e-08
Identities = 26/47 (55%), Positives = 39/47 (82%)
Frame = +1
Query: 508 RVTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEIT 648
++ + GKNVVV+GRS IVG PV+ L+ ++ATVT+ HS+T+NL+E+T
Sbjct: 152 KILLKGKNVVVIGRSNIVGKPVAALMLEQNATVTIAHSETENLAELT 198
Score = 56.4 bits (130), Expect = 6e-07
Identities = 33/88 (37%), Positives = 49/88 (55%), Gaps = 1/88 (1%)
Frame = +2
Query: 242 YPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 421
Y L D + L I LNE P ++G++VQ+P + IDA + + + P+KDVDGL
Sbjct: 66 YQLPADTKQEVALNLIDKLNEDPDINGVMVQLP--APEQIDADELLERIDPNKDVDGLTP 123
Query: 422 INEGRVAVGDLSGFI-PCTPAGCVELIK 502
N GR+ + + FI P T G + L+K
Sbjct: 124 SNIGRIWME--NHFIEPATAEGIIALLK 149
Score = 44.4 bits (100), Expect = 0.002
Identities = 22/71 (30%), Positives = 39/71 (54%)
Frame = +3
Query: 42 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEK 221
M +I+ G VA + L+++V L+ + G P ++ +G S +Y+R K + AEK
Sbjct: 1 MGKILDGKFVANLLGEKLKEKVKDLKEE--GITPHFCVINIGDDPASKIYVRTKKRRAEK 58
Query: 222 IGIAAEHIRLP 254
+GI + +LP
Sbjct: 59 MGIIQDIYQLP 69
>UniRef50_A7DNA7 Cluster: Methylenetetrahydrofolate dehydrogenase
(NADP(+)); n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Methylenetetrahydrofolate dehydrogenase
(NADP(+)) - Candidatus Nitrosopumilus maritimus SCM1
Length = 287
Score = 60.9 bits (141), Expect = 3e-08
Identities = 33/87 (37%), Positives = 49/87 (56%)
Frame = +2
Query: 236 RTYPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGL 415
+ + L T+ +L I +LN SVHGI+VQ+PL +D T +SP KDVDGL
Sbjct: 65 KDHKLDASTTQAQLNEIIENLNNDNSVHGILVQLPLPEQ--LDEFTTTSRISPLKDVDGL 122
Query: 416 NTINEGRVAVGDLSGFIPCTPAGCVEL 496
N G +A+ + + CTP+G +E+
Sbjct: 123 TPHNAGLLAM-KKAALVACTPSGVMEM 148
Score = 52.4 bits (120), Expect = 9e-06
Identities = 22/45 (48%), Positives = 33/45 (73%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEI 645
+ + GKN+V++ RS +VG P+ LL ++ATV CHS+TKNL E+
Sbjct: 154 IELEGKNIVLINRSNLVGKPLYHLLLDKNATVITCHSRTKNLVEL 198
Score = 38.7 bits (86), Expect = 0.12
Identities = 21/70 (30%), Positives = 40/70 (57%)
Frame = +3
Query: 54 ISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIA 233
I G ++ S+++ +++ V L+++ G P LA V VG S Y+R K +A E++GI
Sbjct: 6 IDGKVISQSVKDRVKKAVEELKNQ--GINPCLATVLVGDNPASATYVRNKHRACEEVGIT 63
Query: 234 AEHIRLPGTS 263
+ +L ++
Sbjct: 64 TKDHKLDAST 73
>UniRef50_Q14NV1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Spiroplasma citri|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Spiroplasma citri
Length = 286
Score = 60.9 bits (141), Expect = 3e-08
Identities = 27/47 (57%), Positives = 38/47 (80%)
Frame = +1
Query: 508 RVTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEIT 648
++ +AG++VV++GRS IVG P++ LL ATVTVCHS+TKNLS+ T
Sbjct: 155 QIQLAGQHVVIIGRSNIVGKPLANLLINASATVTVCHSQTKNLSDFT 201
Score = 49.2 bits (112), Expect = 8e-05
Identities = 28/81 (34%), Positives = 44/81 (54%)
Frame = +2
Query: 260 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 439
ITE L+ I LN + + I+VQ+PL S I++ +V + + KDVDG G +
Sbjct: 75 ITESALIKIINDLNNNSKIDAILVQLPLPSH--INSEKVINTIITKKDVDGFTPKILGNL 132
Query: 440 AVGDLSGFIPCTPAGCVELIK 502
+G + +P TP G + L+K
Sbjct: 133 MLGHYN-LLPSTPKGIIALLK 152
Score = 42.3 bits (95), Expect = 0.010
Identities = 21/69 (30%), Positives = 39/69 (56%)
Frame = +3
Query: 48 QIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIG 227
+II G V+ I+ + +Q+ ++++K P L I+Q+G + S YI+ K A EK+G
Sbjct: 5 KIIDGKMVSELIKAKITEQILKIKAKKQRV-PALTIIQIGNNKASTTYIKNKKIACEKVG 63
Query: 228 IAAEHIRLP 254
+ + + P
Sbjct: 64 VTCKVLNYP 72
>UniRef50_Q6MI74 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Bdellovibrio bacteriovorus|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Bdellovibrio
bacteriovorus
Length = 288
Score = 60.9 bits (141), Expect = 3e-08
Identities = 27/47 (57%), Positives = 36/47 (76%)
Frame = +1
Query: 508 RVTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEIT 648
R+ + GK VV+GRS IVG P++ LL +ATVT+CHSKT N+SE+T
Sbjct: 153 RIPVEGKKAVVVGRSNIVGKPMALLLTEANATVTLCHSKTSNMSELT 199
Score = 49.6 bits (113), Expect = 6e-05
Identities = 31/87 (35%), Positives = 44/87 (50%)
Frame = +2
Query: 242 YPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 421
+ L + T+ EL ++ LN V GI+VQ PL + + V VS +KD DGL
Sbjct: 67 HTLPAETTQSELNQILSKLNNDNGVDGILVQFPLPKH--LSSDEVLKLVSAEKDADGLTY 124
Query: 422 INEGRVAVGDLSGFIPCTPAGCVELIK 502
+ G G PCTPAG +E++K
Sbjct: 125 ESLGYFFAGK-PLVSPCTPAGVMEILK 150
Score = 42.7 bits (96), Expect = 0.007
Identities = 25/71 (35%), Positives = 40/71 (56%)
Frame = +3
Query: 42 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEK 221
M I+ G EVA + L +V + + + G P+L++V VG + S+VY++ K A EK
Sbjct: 1 MVLILDGKEVAKEVRASLVPRVAKFKETY-GRAPQLSVVIVGDDKASHVYVKNKKIACEK 59
Query: 222 IGIAAEHIRLP 254
IG+ + LP
Sbjct: 60 IGMTSTIHTLP 70
>UniRef50_UPI000065DF90 Cluster: methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 2-like; n=1; Takifugu
rubripes|Rep: methylenetetrahydrofolate dehydrogenase
(NADP+ dependent) 2-like - Takifugu rubripes
Length = 400
Score = 60.5 bits (140), Expect = 3e-08
Identities = 31/82 (37%), Positives = 52/82 (63%)
Frame = +2
Query: 260 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 439
+++ ELL I +N V G++VQ+PL +H I+ V +A++P+KDVDG + +N G++
Sbjct: 78 VSQEELLELIDKMNRDWRVSGLLVQLPLP-EH-INERAVCNAIAPEKDVDGFHIVNIGKL 135
Query: 440 AVGDLSGFIPCTPAGCVELIKK 505
+ D +P TPA E+IK+
Sbjct: 136 CL-DQRSMVPATPAAVWEIIKR 156
Score = 43.6 bits (98), Expect = 0.004
Identities = 22/74 (29%), Positives = 42/74 (56%)
Frame = +3
Query: 39 KMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAE 218
+ A +ISG E+A I+ ++++ V L ++ P L +V VG S Y++ K +AA
Sbjct: 5 RAAVVISGTELARQIQREIQRDVEELVAQ-GNMRPHLGVVLVGEDPASRTYVKNKTRAAS 63
Query: 219 KIGIAAEHIRLPGT 260
+GI+++ + P +
Sbjct: 64 ILGISSDTVVRPSS 77
>UniRef50_UPI00006CCCC6 Cluster: methylenetetrahydrofolate
dehydrogenase; n=1; Tetrahymena thermophila SB210|Rep:
methylenetetrahydrofolate dehydrogenase - Tetrahymena
thermophila SB210
Length = 342
Score = 59.7 bits (138), Expect = 6e-08
Identities = 30/92 (32%), Positives = 52/92 (56%)
Frame = +2
Query: 230 RRRTYPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVD 409
R Y + DI E ++L+ I +LN + I+ Q+PL S ID + V + +S +KD D
Sbjct: 79 RHELYHFSEDIQEYDVLSAIDNLNRKDDIDAIMAQLPLPSH--IDKNNVINMISSEKDAD 136
Query: 410 GLNTINEGRVAVGDLSGFIPCTPAGCVELIKK 505
GL +N + + +PCTPA C++++++
Sbjct: 137 GLK-LNSNNL--DPKANILPCTPAACLKILEE 165
Score = 38.3 bits (85), Expect = 0.16
Identities = 17/48 (35%), Positives = 31/48 (64%), Gaps = 1/48 (2%)
Frame = +1
Query: 502 EDRVTIAGKNVVVLGRSRIVGTPVSELL-KWEHATVTVCHSKTKNLSE 642
E ++ + K+VV++GR R+VG P+ +LL K A +T C +T ++ +
Sbjct: 165 EHQICLKDKHVVLIGRGRLVGQPLEQLLSKLSPAQITTCVKETGDIKQ 212
Score = 34.7 bits (76), Expect = 2.0
Identities = 24/79 (30%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Frame = +3
Query: 6 SARANETVLWAKMAQIISGIEVAGSIENDLRQQVTRLRSKWS-GFEPRLAIVQVGGREDS 182
S A T+ ++ + +G + A I + LR+++ + + +P L I+ VG S
Sbjct: 3 STFACRTLRYSFSTVVFNGNKSAKKILSSLRKEIEWFQKQSDLSRKPGLGIILVGNNPAS 62
Query: 183 NVYIRMKLKAAEKIGIAAE 239
YI+ KL+A E IGI E
Sbjct: 63 LSYIKKKLQACEAIGIRHE 81
>UniRef50_Q3A1Q7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Pelobacter carbinolicus (strain DSM 2380 / Gra Bd 1)
Length = 290
Score = 59.7 bits (138), Expect = 6e-08
Identities = 29/74 (39%), Positives = 44/74 (59%)
Frame = +2
Query: 263 TEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVA 442
T+ +LLA + N+SP V I+Q PL D + + + P+KD DGL+ +N GR+
Sbjct: 74 TQSDLLAAVRDFNDSPDVDAYIIQYPLPK--GFDFNEALNLMLPEKDADGLHPVNLGRLV 131
Query: 443 VGDLSGFIPCTPAG 484
+ + G +PCTPAG
Sbjct: 132 LQE-PGPVPCTPAG 144
Score = 37.9 bits (84), Expect = 0.21
Identities = 22/50 (44%), Positives = 29/50 (58%), Gaps = 4/50 (8%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELL----KWEHATVTVCHSKTKNLSEIT 648
+ I GK VVV+GR +G P+S LL + +A VTV HS K+L T
Sbjct: 154 IAIEGKEVVVIGRGPTLGRPLSLLLTLKQPYANAAVTVVHSGIKDLGAYT 203
>UniRef50_Q987T6 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Alphaproteobacteria|Rep: Bifunctional protein folD
2 [Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rhizobium loti (Mesorhizobium loti)
Length = 306
Score = 59.3 bits (137), Expect = 8e-08
Identities = 37/94 (39%), Positives = 50/94 (53%)
Frame = +2
Query: 227 YRRRTYPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDV 406
+ R +P T IT EL A I LN P V GII+Q P+ + I + AV P KDV
Sbjct: 68 FEERRFPAT--ITSGELEAAIHGLNADPRVTGIIIQRPVPAH--ISVKTLQAAVHPLKDV 123
Query: 407 DGLNTINEGRVAVGDLSGFIPCTPAGCVELIKKT 508
+G++ + G + L PCT A VEL+K+T
Sbjct: 124 EGMHPASIGNIVYNQLD-LAPCTAAASVELLKET 156
Score = 46.0 bits (104), Expect = 8e-04
Identities = 22/46 (47%), Positives = 31/46 (67%)
Frame = +1
Query: 502 EDRVTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLS 639
E + + G VVV+G S IVG P++ LL E ATVTVCH T++++
Sbjct: 155 ETGLDLKGLEVVVVGHSEIVGKPIAFLLMSEGATVTVCHHLTRSVA 200
Score = 34.3 bits (75), Expect = 2.6
Identities = 17/47 (36%), Positives = 25/47 (53%)
Frame = +3
Query: 120 SKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPGT 260
+K GF P+L + VG + +VY+R + A+ GI E R P T
Sbjct: 30 AKAEGFPPKLISITVGDTDAVDVYVRNQRAKAQLAGIDFEERRFPAT 76
>UniRef50_O51057 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Borrelia burgdorferi group|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Borrelia burgdorferi
(Lyme disease spirochete)
Length = 308
Score = 58.8 bits (136), Expect = 1e-07
Identities = 28/77 (36%), Positives = 49/77 (63%)
Frame = +2
Query: 272 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVAVGD 451
++L I N++ S GIIVQ+PL +D + + +++ KDVDGL+ +N G++ +GD
Sbjct: 82 DILEVIDRENKNLSTDGIIVQLPLLK--GMDLNSILNSIVYSKDVDGLSFVNLGKMILGD 139
Query: 452 LSGFIPCTPAGCVELIK 502
GFIPCT +++++
Sbjct: 140 KKGFIPCTALAVLKILR 156
Score = 43.2 bits (97), Expect = 0.006
Identities = 23/44 (52%), Positives = 30/44 (68%), Gaps = 2/44 (4%)
Frame = +1
Query: 502 EDRVTIAGKNVVVLGRSRIVGTPVSELL--KWEHATVTVCHSKT 627
++ + GK VVV+GRS +VG P+S LL K ATV VCHSK+
Sbjct: 157 DEGIKTLGKTVVVVGRSPLVGRPISILLSSKPYDATVIVCHSKS 200
>UniRef50_Q8RAD0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Thermoanaerobacter|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermoanaerobacter tengcongensis
Length = 280
Score = 58.4 bits (135), Expect = 1e-07
Identities = 27/74 (36%), Positives = 43/74 (58%)
Frame = +2
Query: 287 ITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVAVGDLSGFI 466
+ LNE HGI+++MPL +D +V D ++P KDVD ++ N GR+ G F+
Sbjct: 78 LEKLNEDKDTHGIMIEMPLPKGFDVD--KVYDTINPYKDVDCISNYNMGRLFAGK-PLFV 134
Query: 467 PCTPAGCVELIKKT 508
PCTP + +++ T
Sbjct: 135 PCTPKAIIHILENT 148
Score = 55.6 bits (128), Expect = 1e-06
Identities = 25/43 (58%), Positives = 35/43 (81%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLS 639
V + GK+ VV+GRS I+G PV++LL ++ TVTVCHSKTK+L+
Sbjct: 150 VDLEGKHAVVIGRSNILGKPVAKLLLDKNCTVTVCHSKTKDLA 192
Score = 47.6 bits (108), Expect = 3e-04
Identities = 23/63 (36%), Positives = 38/63 (60%)
Frame = +3
Query: 51 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGI 230
II G E++ I+ ++++++ G++PRLAI+ G E S VY K+KA E +GI
Sbjct: 5 IIDGKEISNRIKEEVKREIQEF-----GYKPRLAILMAGDDESSKVYANSKVKACESVGI 59
Query: 231 AAE 239
A+
Sbjct: 60 EAK 62
>UniRef50_Q4FTX6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=24; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Psychrobacter arcticum
Length = 295
Score = 58.4 bits (135), Expect = 1e-07
Identities = 31/80 (38%), Positives = 47/80 (58%)
Frame = +2
Query: 263 TEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVA 442
T EL+AKI LN +P VHGI++Q P+ + ID + + KDVDG+ + GR+A
Sbjct: 86 TTAELMAKIDELNNNPDVHGILLQHPVPAH--IDERACFEQIDLAKDVDGVTCLGFGRMA 143
Query: 443 VGDLSGFIPCTPAGCVELIK 502
+ S + CTP G + L++
Sbjct: 144 M-QQSAYGSCTPQGIMHLLE 162
Score = 45.6 bits (103), Expect = 0.001
Identities = 19/42 (45%), Positives = 31/42 (73%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNL 636
+ +AG VV+GRS I+G P++ +L + TVT+CHS+T++L
Sbjct: 166 IELAGLEAVVVGRSAILGKPMAMMLLNANCTVTICHSRTQDL 207
>UniRef50_A6LP88 Cluster: Tetrahydrofolate
dehydrogenase/cyclohydrolase; n=1; Thermosipho
melanesiensis BI429|Rep: Tetrahydrofolate
dehydrogenase/cyclohydrolase - Thermosipho melanesiensis
BI429
Length = 271
Score = 57.6 bits (133), Expect = 2e-07
Identities = 28/51 (54%), Positives = 38/51 (74%), Gaps = 2/51 (3%)
Frame = +1
Query: 502 EDRVTIAGKNVVVLGRSRIVGTPVSELL--KWEHATVTVCHSKTKNLSEIT 648
E+ + I GKNVV++GRS VG P++ +L + ATVTVCH+KT+NLS IT
Sbjct: 140 ENEIGIPGKNVVIVGRSNTVGKPLAIMLLRRDRSATVTVCHTKTRNLSSIT 190
>UniRef50_Q74J95 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Lactobacillus|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Lactobacillus johnsonii
Length = 283
Score = 57.6 bits (133), Expect = 2e-07
Identities = 27/89 (30%), Positives = 54/89 (60%), Gaps = 1/89 (1%)
Frame = +2
Query: 236 RTYPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGL 415
R +P +D+++ E+L I N+ P++H I++Q+PL ++ + +A++P+KDVDG
Sbjct: 66 RKFP--KDVSQAEVLQAIHHYNDDPTIHAILIQLPLPKH--LNQTELIEAIAPEKDVDGF 121
Query: 416 NTINEGRVAVGDLSGF-IPCTPAGCVELI 499
N+ N G++ + + + CT G + L+
Sbjct: 122 NSKNVGKLYNNEEGHYPVSCTSRGIMTLL 150
Score = 36.7 bits (81), Expect = 0.48
Identities = 19/44 (43%), Positives = 26/44 (59%)
Frame = +1
Query: 517 IAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEIT 648
I G NV ++GRS +V P+ LL E+ATVT+ T N+ T
Sbjct: 157 IEGLNVTIVGRSILVSRPLQSLLINENATVTMVSLHTDNIDYYT 200
>UniRef50_Q9HPY4 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Halobacterium salinarium (Halobacterium
halobium)
Length = 297
Score = 57.2 bits (132), Expect = 3e-07
Identities = 34/75 (45%), Positives = 41/75 (54%)
Frame = +2
Query: 275 LLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVAVGDL 454
L + LN VHGI+VQ P DH D RV AV P KDVDG + N G++ VG
Sbjct: 77 LFDTVAELNAREDVHGILVQDPTP-DHVPD-ERVLSAVDPAKDVDGFHPENVGKL-VGGT 133
Query: 455 SGFIPCTPAGCVELI 499
F PCTP G +L+
Sbjct: 134 PRFKPCTPHGVQKLL 148
Score = 50.0 bits (114), Expect = 5e-05
Identities = 27/70 (38%), Positives = 40/70 (57%)
Frame = +3
Query: 42 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEK 221
M +II G VA + DL V L + +G PRLA V + ++ S Y+ MK + E+
Sbjct: 1 MTEIIDGDAVAAQLRADLTGAVETLET--AGVTPRLATVLMNDKQASETYVSMKQQDCEE 58
Query: 222 IGIAAEHIRL 251
+GIAAE +R+
Sbjct: 59 VGIAAEDVRI 68
Score = 43.2 bits (97), Expect = 0.006
Identities = 23/46 (50%), Positives = 31/46 (67%), Gaps = 4/46 (8%)
Frame = +1
Query: 523 GKNVVVLGRSRIVGTPVSELLKWE----HATVTVCHSKTKNLSEIT 648
G VVV+GRS IVG P++ LL + +ATVT+CHS T +L+ T
Sbjct: 157 GAEVVVVGRSNIVGKPLANLLAQKAAGGNATVTICHSHTDDLAAHT 202
>UniRef50_Q2B9L0 Cluster: Bifunctional protein FolD; n=1; Bacillus
sp. NRRL B-14911|Rep: Bifunctional protein FolD -
Bacillus sp. NRRL B-14911
Length = 322
Score = 56.8 bits (131), Expect = 4e-07
Identities = 30/84 (35%), Positives = 48/84 (57%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
+ ++ T EL+ I LNE+ VHGI++Q P+ ID + + +S DKDVDG+ +
Sbjct: 109 MPKETTTEELVKTIEELNENKEVHGILLQHPVPGH--IDERKAFETISIDKDVDGVTSHG 166
Query: 428 EGRVAVGDLSGFIPCTPAGCVELI 499
G+ A+G + CTPA + +I
Sbjct: 167 YGQTALG-FGTYPSCTPAAIMAII 189
Score = 52.4 bits (120), Expect = 9e-06
Identities = 25/41 (60%), Positives = 31/41 (75%)
Frame = +1
Query: 517 IAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLS 639
+ GK+ VV+GRS I+G PVS LL +ATVT CHS T+NLS
Sbjct: 196 VEGKHAVVVGRSPILGKPVSALLLNRNATVTTCHSYTENLS 236
Score = 46.0 bits (104), Expect = 8e-04
Identities = 25/68 (36%), Positives = 35/68 (51%)
Frame = +3
Query: 51 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGI 230
I+ G VA ++ L +V L K G P LA + VG S Y+RMK A ++GI
Sbjct: 45 ILDGKRVAADVKEGLMPRVENLTQK--GITPCLATILVGDDPSSETYVRMKGNACARLGI 102
Query: 231 AAEHIRLP 254
+E I +P
Sbjct: 103 RSERIHMP 110
>UniRef50_A5V1H2 Cluster: Methylenetetrahydrofolate dehydrogenase
(NADP(+)); n=5; Chloroflexi (class)|Rep:
Methylenetetrahydrofolate dehydrogenase (NADP(+)) -
Roseiflexus sp. RS-1
Length = 288
Score = 56.4 bits (130), Expect = 6e-07
Identities = 31/86 (36%), Positives = 51/86 (59%)
Frame = +2
Query: 242 YPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 421
+ L + T+ L I++L+ ++HGI++ +PL +D+ R + P KDVDG++
Sbjct: 68 HTLPPETTQAMLEETISALSFDRTIHGILLHLPLPP--GLDSARAIAQIDPAKDVDGVHP 125
Query: 422 INEGRVAVGDLSGFIPCTPAGCVELI 499
N G +A+G G IP TPAG +EL+
Sbjct: 126 YNAGLLAMG-RPGLIPNTPAGGMELL 150
Score = 50.4 bits (115), Expect = 4e-05
Identities = 21/47 (44%), Positives = 35/47 (74%)
Frame = +1
Query: 505 DRVTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEI 645
+ + + G++ V+GRS +VG P++ LL EHATVT+ HS+TK+L+ +
Sbjct: 153 NNIPLKGQHATVVGRSVVVGKPMALLLLNEHATVTIAHSRTKDLAAV 199
>UniRef50_A4M873 Cluster: Tetrahydrofolate
dehydrogenase/cyclohydrolase; n=1; Petrotoga mobilis
SJ95|Rep: Tetrahydrofolate dehydrogenase/cyclohydrolase
- Petrotoga mobilis SJ95
Length = 273
Score = 56.0 bits (129), Expect = 7e-07
Identities = 28/51 (54%), Positives = 35/51 (68%), Gaps = 2/51 (3%)
Frame = +1
Query: 502 EDRVTIAGKNVVVLGRSRIVGTPVSELLK--WEHATVTVCHSKTKNLSEIT 648
ED + GKN+V+LGRS VG P + +L+ ATVTV H+KTKNL EIT
Sbjct: 138 EDTTDVRGKNIVILGRSTTVGKPAAIMLQRHGRDATVTVTHTKTKNLKEIT 188
Score = 36.3 bits (80), Expect = 0.64
Identities = 28/111 (25%), Positives = 53/111 (47%), Gaps = 4/111 (3%)
Frame = +2
Query: 197 DEAEGS*ENWYRR--RTYPLTRDITEI-ELLAKITSLNESPSVHGIIVQMPLDSDHA-ID 364
DE+ S N +R + + + +I E +L + NE I + PL + +D
Sbjct: 37 DESTKSYLNSQKRNAKKFGINLEIVESNDLTNDLRKYNEDDDTDAIFIARPLKKGYTELD 96
Query: 365 AHRVTDAVSPDKDVDGLNTINEGRVAVGDLSGFIPCTPAGCVELIKKTASL 517
+ ++P+KDV+G++ N G + + F+PCT V++I+ T +
Sbjct: 97 ---IAKYINPEKDVEGVSLHNIGSMFY-EKELFVPCTAEAVVKIIEDTTDV 143
>UniRef50_Q8ZZK1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Pyrobaculum|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Pyrobaculum aerophilum
Length = 311
Score = 56.0 bits (129), Expect = 7e-07
Identities = 34/79 (43%), Positives = 44/79 (55%), Gaps = 2/79 (2%)
Frame = +2
Query: 272 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVAVG- 448
E L I SLN V G+I+Q PL +D + A+SP+KDVD L N+ R+
Sbjct: 83 EALRLIESLNRRDDVTGVIIQKPLPP--FVDEKALFSALSPEKDVDALTPENKKRLLTDF 140
Query: 449 DLS-GFIPCTPAGCVELIK 502
DL +PCTPAG +EL K
Sbjct: 141 DLDRDVLPCTPAGILELFK 159
Score = 39.5 bits (88), Expect = 0.069
Identities = 17/40 (42%), Positives = 28/40 (70%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTK 630
+ + GK+VVV+G+ +VG P++ +L ATVTV H+ +K
Sbjct: 163 IDVRGKDVVVVGKGELVGKPLAVMLMQLDATVTVLHALSK 202
>UniRef50_Q0AWX5 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Syntrophomonas wolfei subsp. wolfei str.
Goettingen|Rep: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Syntrophomonas wolfei subsp. wolfei (strain Goettingen)
Length = 272
Score = 55.2 bits (127), Expect = 1e-06
Identities = 28/81 (34%), Positives = 48/81 (59%)
Frame = +2
Query: 260 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 439
+ E ELL I LN S + GI++Q PL + +++A + +A+ DKDV+G++ N G++
Sbjct: 65 VGERELLKTIGDLNNSSEITGIMLQTPLPA--SLNASHLVNAIDFDKDVEGIHNYNLGKL 122
Query: 440 AVGDLSGFIPCTPAGCVELIK 502
+ G PCTP + ++K
Sbjct: 123 -ISKEEGVRPCTPKAVISMLK 142
Score = 52.8 bits (121), Expect = 7e-06
Identities = 21/44 (47%), Positives = 34/44 (77%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSE 642
+ I G+ V ++GRS VG+P++ ++ E+ATVTVCH++T+NL E
Sbjct: 146 ILIEGQKVTIIGRSMTVGSPLALMMTAENATVTVCHTRTRNLKE 189
Score = 36.3 bits (80), Expect = 0.64
Identities = 20/56 (35%), Positives = 31/56 (55%), Gaps = 1/56 (1%)
Frame = +3
Query: 90 DLRQQVT-RLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLP 254
D+R+Q+ R+R + LAI++VG S Y+R K AE+ G+ E + LP
Sbjct: 7 DIREQIKERVRQSAEEVKMGLAIIRVGDDPSSMAYVRGIRKFAEETGVKVEIVNLP 62
>UniRef50_Q0SFQ8 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Actinomycetales|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rhodococcus sp. (strain RHA1)
Length = 297
Score = 55.2 bits (127), Expect = 1e-06
Identities = 29/76 (38%), Positives = 43/76 (56%)
Frame = +2
Query: 272 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVAVGD 451
++ + + L P VHGII+Q PL +DA R +A++P KDVDG N ++ GR+ V
Sbjct: 76 QIRSTLVELGHDPDVHGIILQTPLPDGTDLDALR--EAINPAKDVDGANPVSLGRL-VAR 132
Query: 452 LSGFIPCTPAGCVELI 499
L F P T + L+
Sbjct: 133 LPAFAPATAQAVIALL 148
Score = 44.0 bits (99), Expect = 0.003
Identities = 19/38 (50%), Positives = 27/38 (71%)
Frame = +1
Query: 526 KNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLS 639
+ V+GRS +VG+PV+ LL +ATVTVCH T +L+
Sbjct: 158 RTATVVGRSTVVGSPVAHLLVQRNATVTVCHRHTTDLA 195
Score = 37.9 bits (84), Expect = 0.21
Identities = 23/70 (32%), Positives = 34/70 (48%)
Frame = +3
Query: 42 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEK 221
M + + G E+A SI ND L G P+LA+VQ E + Y+R AA++
Sbjct: 1 MTRSLGGAELATSIRNDASVAAAALNDL--GTRPKLAVVQATDDESTAWYVRSIASAAKR 58
Query: 222 IGIAAEHIRL 251
GI + + L
Sbjct: 59 TGILCDIVDL 68
>UniRef50_Q8W528 Cluster: Methylenetetrahydrofolate
dehydrogenase/methylenetetrahydrofolate cylcohydrolase
isoform 1; n=11; Viridiplantae|Rep:
Methylenetetrahydrofolate
dehydrogenase/methylenetetrahydrofolate cylcohydrolase
isoform 1 - Zea mays (Maize)
Length = 160
Score = 54.8 bits (126), Expect = 2e-06
Identities = 27/45 (60%), Positives = 33/45 (73%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEI 645
++I GKN VV+GRS IVG PVS LL E ATVT+ HS+TK +I
Sbjct: 41 ISIKGKNAVVVGRSNIVGLPVSLLLLKEDATVTIVHSRTKEPEKI 85
Score = 44.4 bits (100), Expect = 0.002
Identities = 18/39 (46%), Positives = 29/39 (74%), Gaps = 1/39 (2%)
Frame = +2
Query: 395 DKDVDGLNTINEGRVAV-GDLSGFIPCTPAGCVELIKKT 508
+KDVDG + +N G++A+ G F+PCTP GC+EL+ ++
Sbjct: 1 EKDVDGFHPLNIGKLAMKGRQPLFLPCTPKGCIELLHRS 39
>UniRef50_Q04FB7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Leuconostocaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Oenococcus oeni (strain BAA-331 / PSU-1)
Length = 285
Score = 54.4 bits (125), Expect = 2e-06
Identities = 28/78 (35%), Positives = 45/78 (57%), Gaps = 1/78 (1%)
Frame = +2
Query: 272 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVAVGD 451
++L ++ LN S+ GI+VQ PL ID ++ +A+ P KD DGL+ N+G +
Sbjct: 73 DILRLLSKLNMDSSICGILVQSPLGD--GIDESKIFNAIDPLKDADGLSAFNQGLLFENA 130
Query: 452 LSGFI-PCTPAGCVELIK 502
+I P TPAG + L++
Sbjct: 131 KENYIVPATPAGVISLLE 148
Score = 39.1 bits (87), Expect = 0.091
Identities = 19/36 (52%), Positives = 24/36 (66%)
Frame = +1
Query: 520 AGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKT 627
A KN +V+GRS + G P+S LL TVT+ HSKT
Sbjct: 155 AAKNALVVGRSVLFGRPMSVLLTNRDMTVTLAHSKT 190
>UniRef50_Q057D7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Enterobacteriaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Buchnera aphidicola subsp. Cinara cedri
Length = 284
Score = 54.4 bits (125), Expect = 2e-06
Identities = 30/86 (34%), Positives = 48/86 (55%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L+ I EIEL+ I LN++ + GI++Q+PL I+ ++ ++ P KDVDG + N
Sbjct: 70 LSNQIEEIELINLIKKLNKNKCIDGILIQLPLPI--KINYLKIITSIDPKKDVDGFHPYN 127
Query: 428 EGRVAVGDLSGFIPCTPAGCVELIKK 505
G + + F CT G + L+KK
Sbjct: 128 LGSLCQNN-PQFRSCTSKGVITLLKK 152
Score = 33.5 bits (73), Expect = 4.5
Identities = 16/43 (37%), Positives = 24/43 (55%)
Frame = +1
Query: 508 RVTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNL 636
++ I G V++G S IVG P+ L TVT+ + TKN+
Sbjct: 154 KINIHGLYAVIIGSSNIVGKPMYMELLLAGCTVTIVNKNTKNI 196
>UniRef50_Q1AVQ0 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Rubrobacter xylanophilus DSM 9941|Rep: Bifunctional
protein folD 2 [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Rubrobacter xylanophilus
(strain DSM 9941 / NBRC 16129)
Length = 320
Score = 54.4 bits (125), Expect = 2e-06
Identities = 30/86 (34%), Positives = 47/86 (54%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L R+ E ++LA + LN P V GI+V PL I V A+ P KD++ ++ +N
Sbjct: 69 LPREAEEADVLAVVGKLNADPRVSGILVLRPLPGH--ISEPAVFSALDPLKDIEAVHPVN 126
Query: 428 EGRVAVGDLSGFIPCTPAGCVELIKK 505
G +A+G ++P TPA C L+ +
Sbjct: 127 AGLLALGR-PRYVPSTPAACFYLLDR 151
>UniRef50_Q2JCX4 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Frankia|Rep: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Frankia sp. (strain CcI3)
Length = 276
Score = 54.4 bits (125), Expect = 2e-06
Identities = 30/77 (38%), Positives = 45/77 (58%)
Frame = +2
Query: 275 LLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVAVGDL 454
+L I ++ P+VHGIIVQ PL + + V + + KDVDG+N + GR+A+G L
Sbjct: 74 ILDTIDTVAADPTVHGIIVQTPLPG--GLTSREVGEHIPTAKDVDGMNPSSLGRLALG-L 130
Query: 455 SGFIPCTPAGCVELIKK 505
F P T A VE++ +
Sbjct: 131 PSFAPATAAAVVEILTR 147
Score = 53.6 bits (123), Expect = 4e-06
Identities = 25/46 (54%), Positives = 32/46 (69%)
Frame = +1
Query: 508 RVTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEI 645
R+ ++G V V+GR +VG PVS LL E ATVT+CHS+TK L I
Sbjct: 149 RIPMSGARVCVIGRGPVVGKPVSLLLLAEDATVTICHSRTKGLVSI 194
>UniRef50_A4EAK0 Cluster: Putative uncharacterized protein; n=3;
Bacteria|Rep: Putative uncharacterized protein -
Collinsella aerofaciens ATCC 25986
Length = 284
Score = 53.6 bits (123), Expect = 4e-06
Identities = 30/71 (42%), Positives = 41/71 (57%)
Frame = +3
Query: 42 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEK 221
MA+++ G VA ++ +L + LR + G P LAIV+VG RED Y R LK EK
Sbjct: 1 MAELLKGAPVARALTEELAARCAALREQ--GVVPMLAIVRVGEREDDLSYERGALKRCEK 58
Query: 222 IGIAAEHIRLP 254
+GI A + LP
Sbjct: 59 VGIEARRVLLP 69
Score = 52.4 bits (120), Expect = 9e-06
Identities = 28/81 (34%), Positives = 42/81 (51%)
Frame = +2
Query: 257 DITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGR 436
D+++ ELLA I +N P+VHG ++ PL + +D V A+ P KDVD + +
Sbjct: 71 DVSQDELLAAIKDINADPAVHGCLMFRPLPA--GLDEDAVAAALDPAKDVDSMTPASLLT 128
Query: 437 VAVGDLSGFIPCTPAGCVELI 499
G GF PCT + L+
Sbjct: 129 TLSGRGEGFAPCTAEAVLALL 149
Score = 45.6 bits (103), Expect = 0.001
Identities = 19/43 (44%), Positives = 30/43 (69%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLS 639
V + G V V+GRS ++G PV+ +L +ATVT CH+ T++L+
Sbjct: 154 VELDGAKVAVVGRSLVIGRPVAAMLTARNATVTTCHTHTRDLA 196
>UniRef50_Q8EV80 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma penetrans|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma penetrans
Length = 282
Score = 53.6 bits (123), Expect = 4e-06
Identities = 24/49 (48%), Positives = 34/49 (69%)
Frame = +1
Query: 502 EDRVTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEIT 648
+ +I GK+ V++ RS IVG P+ L +ATVTVCH+KT+NL E+T
Sbjct: 149 QSNYSIEGKHAVIINRSMIVGKPLIGLFLENNATVTVCHTKTQNLKEMT 197
Score = 48.8 bits (111), Expect = 1e-04
Identities = 26/83 (31%), Positives = 49/83 (59%), Gaps = 1/83 (1%)
Frame = +2
Query: 263 TEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGR-V 439
T+ +L+ +I LN S+ G I+Q+PL D++ + + + +KD+DGL++ R +
Sbjct: 70 TQDDLIKQIHILNNDDSIDGYIIQLPLPK--GFDSNVICEHIDVNKDIDGLSSFAISRNL 127
Query: 440 AVGDLSGFIPCTPAGCVELIKKT 508
A +L PCT G +E++K++
Sbjct: 128 ANSNLFHPKPCTANGIIEILKQS 150
Score = 35.1 bits (77), Expect = 1.5
Identities = 17/60 (28%), Positives = 36/60 (60%)
Frame = +3
Query: 51 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGI 230
I++ I++A +I + + + +L+ K P +AIV++ S+ Y+ +KLK A ++G+
Sbjct: 2 IVNCIDIANNILDKFKSDLEKLKKK--KIIPHMAIVKINDDAASDKYVSIKLKKAAELGV 59
>UniRef50_Q86F84 Cluster: Clone ZZD1003 mRNA sequence; n=1;
Schistosoma japonicum|Rep: Clone ZZD1003 mRNA sequence -
Schistosoma japonicum (Blood fluke)
Length = 332
Score = 53.2 bits (122), Expect = 5e-06
Identities = 35/95 (36%), Positives = 48/95 (50%), Gaps = 10/95 (10%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L I+E LL + LN SVHGI +Q+P DSD I+ +AV+ KDV+GLN+ N
Sbjct: 71 LPSHISESLLLDYVYKLNADSSVHGITLQLPFDSDTNINVTNSLNAVATHKDVEGLNSYN 130
Query: 428 EGRVAVGDLSGFI----------PCTPAGCVELIK 502
++V S + CT A C LI+
Sbjct: 131 TALLSVVIYSATLRRLKTKTYSYTCTAAACYALIR 165
Score = 50.4 bits (115), Expect = 4e-05
Identities = 24/68 (35%), Positives = 42/68 (61%)
Frame = +3
Query: 51 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGI 230
I+ G +VA ++ + ++ V L+S + + P+L +++VG S +YI+ K K A+K GI
Sbjct: 6 ILYGRQVAQAVGHKIKLDVALLKSSFDVY-PKLVVIEVGELPQSKLYIKQKFKFAKKYGI 64
Query: 231 AAEHIRLP 254
H+RLP
Sbjct: 65 LLSHMRLP 72
Score = 41.1 bits (92), Expect = 0.022
Identities = 19/43 (44%), Positives = 27/43 (62%), Gaps = 1/43 (2%)
Frame = +1
Query: 517 IAGKNVVVLGRSRIVGTPVSELLKWE-HATVTVCHSKTKNLSE 642
I+G V++GR R+VG P +ELL ATV CH ++ N+ E
Sbjct: 171 ISGSRCVIIGRGRLVGAPTAELLSGSCGATVIQCHLQSANIDE 213
>UniRef50_Q5RGD2 Cluster: Novel protein similar to vertebrate
formyltetrahydrofolate synthetase domain containing 1;
n=1; Danio rerio|Rep: Novel protein similar to
vertebrate formyltetrahydrofolate synthetase domain
containing 1 - Danio rerio (Zebrafish) (Brachydanio
rerio)
Length = 217
Score = 52.4 bits (120), Expect = 9e-06
Identities = 29/82 (35%), Positives = 44/82 (53%), Gaps = 1/82 (1%)
Frame = +2
Query: 263 TEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVA 442
TE E++ ++ LN+ VHGI + +P + V +A+ P KDVDG+ +N GRV
Sbjct: 60 TEEEVIEEVLRLNKDSRVHGIFLHLP----QTFLSKSVRNAIKPQKDVDGVCDLNVGRVV 115
Query: 443 VGD-LSGFIPCTPAGCVELIKK 505
+GD GF +EL+ K
Sbjct: 116 LGDKTDGFTSPVAGAVLELLAK 137
>UniRef50_Q7TU81 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Prochlorococcus marinus|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Prochlorococcus marinus subsp. pastoris
(strain CCMP 1378 / MED4)
Length = 298
Score = 52.4 bits (120), Expect = 9e-06
Identities = 29/79 (36%), Positives = 46/79 (58%)
Frame = +2
Query: 266 EIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVAV 445
E+E L + LN ++ G+++Q+P+ D R+ ++P+KDVDGLN N G++ V
Sbjct: 77 EVEQL--LNKLNLDNNIDGMLLQLPISKK--FDEQRLISFINPEKDVDGLNEQNIGKL-V 131
Query: 446 GDLSGFIPCTPAGCVELIK 502
+ CTPAG V L+K
Sbjct: 132 KNEQAMRSCTPAGIVNLLK 150
Score = 49.6 bits (113), Expect = 6e-05
Identities = 23/45 (51%), Positives = 34/45 (75%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEI 645
+ I GK +VV+GRS +VG P+S ++ +ATVT+ HSKT NL++I
Sbjct: 154 IKIEGKKIVVIGRSLLVGKPLSLMMLNLNATVTITHSKTINLNKI 198
>UniRef50_Q9X288 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Thermotogaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermotoga maritima
Length = 271
Score = 52.0 bits (119), Expect = 1e-05
Identities = 27/51 (52%), Positives = 34/51 (66%), Gaps = 2/51 (3%)
Frame = +1
Query: 502 EDRVTIAGKNVVVLGRSRIVGTPVSELL--KWEHATVTVCHSKTKNLSEIT 648
E ++GK V V+GRS VG P++ +L K ATVTVCHS+T NL EIT
Sbjct: 140 ERETNLSGKRVTVVGRSVTVGKPLALMLLKKGRDATVTVCHSRTVNLEEIT 190
Score = 42.7 bits (96), Expect = 0.007
Identities = 23/87 (26%), Positives = 45/87 (51%)
Frame = +2
Query: 257 DITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGR 436
+++ E+++ + L SV+G+ V P +D + +V +KDV+G+N N G
Sbjct: 62 NVSPEEIVSTLKKLGSDESVNGVFVARPFPL--GLDEKEILSSVPVEKDVEGVNPANLG- 118
Query: 437 VAVGDLSGFIPCTPAGCVELIKKTASL 517
+ + D F PCT V ++++ +L
Sbjct: 119 LLLYDEEIFPPCTAEAAVRILERETNL 145
>UniRef50_A0DMT9 Cluster: Chromosome undetermined scaffold_57, whole
genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_57,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 309
Score = 51.2 bits (117), Expect = 2e-05
Identities = 27/95 (28%), Positives = 52/95 (54%), Gaps = 1/95 (1%)
Frame = +2
Query: 218 ENWYRRRTYPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPD 397
E+ Y I++ E++ +I SLN+ S+ GI+VQ+PL + +++ + +
Sbjct: 63 EHQIHHELYHFPETISQKEIVHRIKSLNQKGSIDGILVQLPLPPH--LSRLEISNEIKLN 120
Query: 398 KDVDGLNTIN-EGRVAVGDLSGFIPCTPAGCVELI 499
KD+D L+ N + + G+ + IPCTPA + ++
Sbjct: 121 KDIDCLHMANFQNLLQNGEDNDIIPCTPAAVLHIL 155
Score = 45.6 bits (103), Expect = 0.001
Identities = 19/39 (48%), Positives = 29/39 (74%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKT 627
+ + +NV V+GRS++VG P+S LL +A VT+CHS+T
Sbjct: 160 IDVRNQNVTVIGRSQLVGFPLSVLLLKRNARVTICHSET 198
>UniRef50_A0C3Q0 Cluster: Chromosome undetermined scaffold_147,
whole genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_147,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 404
Score = 51.2 bits (117), Expect = 2e-05
Identities = 23/44 (52%), Positives = 32/44 (72%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSE 642
V + GK V ++GRS +VG P+S LL+ +ATVTVCH +T NL +
Sbjct: 260 VNVIGKKVTMIGRSFLVGLPLSLLLQKRNATVTVCHRETLNLDQ 303
Score = 42.3 bits (95), Expect = 0.010
Identities = 25/87 (28%), Positives = 49/87 (56%), Gaps = 1/87 (1%)
Frame = +2
Query: 242 YPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 421
+ + ++ + +L+ I +N GI+VQ+PL S ++ + ++ +KDVD L+
Sbjct: 175 FNFSENVGQEQLIKHIQQMNHD----GILVQLPLPSH--LNKLDIIHSIPYEKDVDCLHM 228
Query: 422 INEGRVAV-GDLSGFIPCTPAGCVELI 499
N R+ V G+L +PCTPA ++++
Sbjct: 229 HNLQRILVYGELCEMLPCTPAAVLQIL 255
Score = 33.5 bits (73), Expect = 4.5
Identities = 23/67 (34%), Positives = 35/67 (52%)
Frame = +3
Query: 39 KMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAE 218
K+ I +G ++A +I LR +T S +P+L I VG S Y+ KLKA +
Sbjct: 115 KLKMIFNGNQLANTILKTLR--IT------SEIKPKLGICLVGDSPASKSYVNRKLKACQ 166
Query: 219 KIGIAAE 239
+I + AE
Sbjct: 167 EINVDAE 173
>UniRef50_P47259 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Mycoplasma|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma genitalium
Length = 273
Score = 51.2 bits (117), Expect = 2e-05
Identities = 27/58 (46%), Positives = 40/58 (68%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 421
L+ IT+ EL+ KI SLN +V GII+Q+P+ H +D + + +A++P KDVDGL T
Sbjct: 60 LSNQITQAELIEKIISLNHDVNVTGIILQLPV-YPH-LDKNSLLEAINPLKDVDGLTT 115
>UniRef50_UPI0000DB7ABF Cluster: PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor; n=1; Apis mellifera|Rep:
PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor - Apis mellifera
Length = 407
Score = 50.8 bits (116), Expect = 3e-05
Identities = 30/87 (34%), Positives = 49/87 (56%)
Frame = +2
Query: 239 TYPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLN 418
T L ++ +++ +I +LN+ +V GI+VQ+PL ++ V A+ P KDVDG +
Sbjct: 174 TIHLDEKSSQQDIINEIDNLNKDKTVDGILVQLPLIKH--MNEQEVCQAIIPSKDVDGFH 231
Query: 419 TINEGRVAVGDLSGFIPCTPAGCVELI 499
N G +A+ + +G IP T ELI
Sbjct: 232 LENLGNLAL-NRNGIIPATALAVKELI 257
Score = 40.3 bits (90), Expect = 0.039
Identities = 24/69 (34%), Positives = 37/69 (53%)
Frame = +3
Query: 45 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 224
A II G ++A I+N+L+ V + + P+L ++VG S +Y+ K+KAA I
Sbjct: 110 AIIIDGKKIANKIQNELKITVDNWIND-NKKRPKLVAIKVGNNPASKIYVEKKIKAANFI 168
Query: 225 GIAAEHIRL 251
GI I L
Sbjct: 169 GIENYTIHL 177
>UniRef50_Q6L046 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermoplasmatales|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Picrophilus torridus
Length = 276
Score = 50.8 bits (116), Expect = 3e-05
Identities = 23/48 (47%), Positives = 32/48 (66%)
Frame = +1
Query: 505 DRVTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEIT 648
D + I NV ++ RS +VG P+S +L TVTVCHS+T N++EIT
Sbjct: 145 DYINIKSGNVAIINRSPVVGRPLSMMLLNRDFTVTVCHSRTVNINEIT 192
Score = 33.5 bits (73), Expect = 4.5
Identities = 19/80 (23%), Positives = 42/80 (52%)
Frame = +2
Query: 260 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 439
I+ +L+ + ++S +HGI+++ P+ I+ + V + + KDVDG+ + N G +
Sbjct: 69 ISREDLIKLLKRYSQSDDIHGIMIETPVPG---INYYDVVNEIPFYKDVDGMTSYNLGNL 125
Query: 440 AVGDLSGFIPCTPAGCVELI 499
+ + P T V+++
Sbjct: 126 YLKN-EFIAPATARAVVDIL 144
>UniRef50_Q8RDM4 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Fusobacterium nucleatum|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Fusobacterium nucleatum subsp. nucleatum
Length = 283
Score = 50.8 bits (116), Expect = 3e-05
Identities = 31/88 (35%), Positives = 47/88 (53%)
Frame = +2
Query: 242 YPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 421
Y + +I+E LL I LN+ V GI++ +PL I+A +V +++ KDVDG
Sbjct: 65 YFFSEEISEAYLLNLIDKLNKDTEVDGIMINLPLPPQ--INATKVLNSIKLIKDVDGFKA 122
Query: 422 INEGRVAVGDLSGFIPCTPAGCVELIKK 505
N G + + P TPAG + LI+K
Sbjct: 123 ENLGLLFQNNEGFTSPSTPAGIMALIEK 150
Score = 48.8 bits (111), Expect = 1e-04
Identities = 22/46 (47%), Positives = 32/46 (69%)
Frame = +1
Query: 511 VTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEIT 648
+ + GK+VVV+G S IVG P++ L+ TVT+C+ TKNL+E T
Sbjct: 153 IDLEGKDVVVVGSSNIVGKPIAALILNSRGTVTICNIYTKNLAEKT 198
>UniRef50_Q979W3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermoplasma|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermoplasma volcanium
Length = 281
Score = 48.8 bits (111), Expect = 1e-04
Identities = 26/82 (31%), Positives = 47/82 (57%)
Frame = +2
Query: 257 DITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGR 436
D+T+ EL+ +I L+ V+GI+V+ PL ID + + ++ KDVD L+ N+G
Sbjct: 68 DLTKQELVRRIEELSADKDVNGIMVENPLPK--TIDYYDIVKSIPYYKDVDALSPYNQGS 125
Query: 437 VAVGDLSGFIPCTPAGCVELIK 502
+A+ + +P T V+++K
Sbjct: 126 IAI-NREFLVPATAMAVVDILK 146
Score = 39.5 bits (88), Expect = 0.069
Identities = 18/60 (30%), Positives = 35/60 (58%)
Frame = +3
Query: 48 QIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIG 227
+++ G E+A +L++++ ++ G PRL ++QVG + +Y R K+K +KIG
Sbjct: 4 KLLKGEEIAEKKAEELKERIEKM-----GVSPRLVLLQVGNYSAATIYARAKIKRGKKIG 58
Score = 35.5 bits (78), Expect = 1.1
Identities = 14/36 (38%), Positives = 24/36 (66%)
Frame = +1
Query: 538 VLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEI 645
++ RS +VG P+S ++ TV++CHSKT ++ I
Sbjct: 157 IINRSPVVGRPLSMMMLNRDYTVSICHSKTPDIRSI 192
>UniRef50_UPI00006CB712 Cluster: tetrahydrofolate
dehydrogenase/cyclohydrolase, NAD(P)-binding domain;
n=1; Tetrahymena thermophila SB210|Rep: tetrahydrofolate
dehydrogenase/cyclohydrolase, NAD(P)-binding domain -
Tetrahymena thermophila SB210
Length = 377
Score = 46.0 bits (104), Expect = 8e-04
Identities = 21/76 (27%), Positives = 47/76 (61%)
Frame = +3
Query: 36 AKMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAA 215
A+ +++G +++ + +++++ R+ + EP+LAI+ VG DS Y+ +K +A
Sbjct: 25 AEQPILVNGNKISKDVLQKVKERILRVNIR----EPKLAIILVGNAADSISYVSVKQRAC 80
Query: 216 EKIGIAAEHIRLPGTS 263
+++G+ +E I LP T+
Sbjct: 81 KRVGVQSELIHLPETT 96
Score = 40.7 bits (91), Expect = 0.030
Identities = 24/86 (27%), Positives = 41/86 (47%), Gaps = 2/86 (2%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L T+ E++ + LN+ V I+ Q+P + I V + + P KDVDGL
Sbjct: 92 LPETTTQKEVIQIVEDLNKREDVDSILTQLPFPAQ--ISKTIVINQIEPSKDVDGLQRCF 149
Query: 428 EGRVAVGD--LSGFIPCTPAGCVELI 499
+ + D + +PCTP C+ ++
Sbjct: 150 LTQQLIWDDHNNRALPCTPQSCLHIL 175
Score = 35.9 bits (79), Expect = 0.84
Identities = 14/40 (35%), Positives = 26/40 (65%)
Frame = +1
Query: 508 RVTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKT 627
++ + GK VV+LG+ +VG+P+ +L A V++C K+
Sbjct: 179 KIDVKGKQVVMLGKGLLVGSPLGAILLGRGAIVSMCDKKS 218
>UniRef50_Q6KID0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma mobile|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma mobile
Length = 280
Score = 44.0 bits (99), Expect = 0.003
Identities = 30/90 (33%), Positives = 47/90 (52%)
Frame = +2
Query: 236 RTYPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGL 415
R + I+E +L++ I ES HG+IVQ+PL D ++ ++V KD+DGL
Sbjct: 60 RLIKIPESISEKDLISIIEE--ESKISHGLIVQLPLPLQ--FDQSKILNSVPITKDIDGL 115
Query: 416 NTINEGRVAVGDLSGFIPCTPAGCVELIKK 505
+ N + G S P T G ++LIK+
Sbjct: 116 SEKNSKNLYSGK-SCIQPATARGIIDLIKE 144
Score = 34.7 bits (76), Expect = 2.0
Identities = 16/39 (41%), Positives = 24/39 (61%)
Frame = +3
Query: 138 EPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLP 254
+P IVQVG SN YI+ K+ A +IG+ + I++P
Sbjct: 27 KPVFTIVQVGNLFSSNKYIKTKMDKALEIGVVSRLIKIP 65
>UniRef50_Q4A6B1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma synoviae 53|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Mycoplasma synoviae (strain 53)
Length = 278
Score = 43.2 bits (97), Expect = 0.006
Identities = 27/64 (42%), Positives = 38/64 (59%)
Frame = +3
Query: 48 QIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIG 227
+I+SG E A E DL+Q L +LAI+QVG + +SN Y+ KLK A++IG
Sbjct: 2 KILSGREKA---EQDLKQLKKELDELNLNRPIKLAIIQVGDKMESNRYVEQKLKKAKEIG 58
Query: 228 IAAE 239
I A+
Sbjct: 59 IEAK 62
Score = 37.5 bits (83), Expect = 0.28
Identities = 27/92 (29%), Positives = 45/92 (48%), Gaps = 3/92 (3%)
Frame = +2
Query: 236 RTYPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGL 415
+ + +IT+ LL + +NE+ GI++Q+PL + + DAV +KD+DGL
Sbjct: 62 KCFKFDENITQKRLLLAMDEINENWD--GILIQLPLPKH--LPKEVILDAVPYEKDIDGL 117
Query: 416 NTINE---GRVAVGDLSGFIPCTPAGCVELIK 502
+ NE D F+P +ELI+
Sbjct: 118 SHRNEFILYNEKNSDDKFFVPAAARAVLELIE 149
>UniRef50_Q2UUX1 Cluster: RIB40 genomic DNA, SC009; n=1; Aspergillus
oryzae|Rep: RIB40 genomic DNA, SC009 - Aspergillus
oryzae
Length = 275
Score = 41.1 bits (92), Expect = 0.022
Identities = 27/72 (37%), Positives = 38/72 (52%), Gaps = 8/72 (11%)
Frame = +2
Query: 287 ITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVA-VGDLS-- 457
I ++N + SVHGIIV P+ D D + V+P KDV+GLN R++ ++S
Sbjct: 78 IRAINANNSVHGIIVYYPIFGDRRDD--EIRQLVAPSKDVEGLNHQTLHRISDAAEVSRP 135
Query: 458 -----GFIPCTP 478
IPCTP
Sbjct: 136 PKPGRNVIPCTP 147
>UniRef50_Q9RW02 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Deinococcus|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Deinococcus radiodurans
Length = 299
Score = 41.1 bits (92), Expect = 0.022
Identities = 24/82 (29%), Positives = 42/82 (51%), Gaps = 1/82 (1%)
Frame = +2
Query: 236 RTYPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGL 415
R L T+ L + L+ P+VHGI++++PL + +DA ++ KD++GL
Sbjct: 76 RVVDLGAAATQEALEQTLRELSADPAVHGIVLELPLAA--GLDADAALLHIAARKDIEGL 133
Query: 416 NTINEGRVAVG-DLSGFIPCTP 478
+ N +A G + +P TP
Sbjct: 134 SPANLALIAAGREPEALLPPTP 155
Score = 35.9 bits (79), Expect = 0.84
Identities = 16/43 (37%), Positives = 27/43 (62%)
Frame = +1
Query: 517 IAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSEI 645
+ G V V+G R VG P+ +L + ATVT+C+ T++L+ +
Sbjct: 170 LRGLRVAVIGPGRTVGRPLLFMLNNKGATVTLCNEHTRDLAAV 212
Score = 33.9 bits (74), Expect = 3.4
Identities = 15/33 (45%), Positives = 21/33 (63%)
Frame = +3
Query: 135 FEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIA 233
FEP+L V E S VY++ K K A+K+G+A
Sbjct: 42 FEPQLVSVLASDDEASQVYVQSKAKRAKKLGVA 74
>UniRef50_A7AXK7 Cluster: Putative uncharacterized protein; n=1;
Ruminococcus gnavus ATCC 29149|Rep: Putative
uncharacterized protein - Ruminococcus gnavus ATCC 29149
Length = 276
Score = 40.7 bits (91), Expect = 0.030
Identities = 19/35 (54%), Positives = 26/35 (74%)
Frame = +1
Query: 523 GKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKT 627
GK+ VLGRS+IVG P++ +L + ATVT C+S T
Sbjct: 146 GKDCCVLGRSKIVGLPLTNMLIEKGATVTCCNSTT 180
Score = 35.5 bits (78), Expect = 1.1
Identities = 26/84 (30%), Positives = 43/84 (51%)
Frame = +2
Query: 242 YPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 421
Y T + E+E + IT + +S + GII+Q+P+ + ++ R+ + P+KDVDG
Sbjct: 67 YSNTTEQKEVECV--ITDIAKSDA-DGIIIQLPIPDKYNLE--RLQHLIPPEKDVDGFRK 121
Query: 422 INEGRVAVGDLSGFIPCTPAGCVE 493
S F PCTP G ++
Sbjct: 122 D----------SCFKPCTPKGIID 135
Score = 35.1 bits (77), Expect = 1.5
Identities = 17/56 (30%), Positives = 32/56 (57%)
Frame = +3
Query: 84 ENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRL 251
+ +L++++ L K P LA++Q+ + SN YI+ K K ++IGI H+ +
Sbjct: 16 KKELKEEIKHLDKK-----PVLAVIQIDDDQASNSYIKGKQKDCDEIGIEMRHVNI 66
>UniRef50_A5IXS7 Cluster: FolD bifunctional protein; n=1; Mycoplasma
agalactiae|Rep: FolD bifunctional protein - Mycoplasma
agalactiae
Length = 286
Score = 40.7 bits (91), Expect = 0.030
Identities = 21/62 (33%), Positives = 40/62 (64%)
Frame = +3
Query: 51 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGI 230
I++G +A +L+++ + +K G +P L+I+QVG S++YI+ K+K AE++G+
Sbjct: 3 ILNGKIIAEERTVELKKEFEEI-TKLIGRQPVLSIIQVGDNPASSLYIKNKIKKAEELGV 61
Query: 231 AA 236
A
Sbjct: 62 KA 63
>UniRef50_Q54Z91 Cluster: Methylenetetrahydrofolate dehydrogenase;
n=2; Dictyostelium discoideum|Rep:
Methylenetetrahydrofolate dehydrogenase - Dictyostelium
discoideum AX4
Length = 313
Score = 40.3 bits (90), Expect = 0.039
Identities = 29/93 (31%), Positives = 47/93 (50%), Gaps = 9/93 (9%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
+ + + ++L I N VHGI+V P+ +D++ + D VSP KD++GL+T N
Sbjct: 71 ILKRVERVDLEDLIIEANNDSCVHGILVYYPVFGG-MMDSY-LQDVVSPTKDIEGLSTQN 128
Query: 428 EG------RVAVGDLSG---FIPCTPAGCVELI 499
R G+ + IPCTP V++I
Sbjct: 129 RFNLYHNIRFMDGETATKKCVIPCTPLAMVKII 161
>UniRef50_Q8KEH0 Cluster: Methylenetetrahydrofolate dehydrogenase;
n=1; Chlorobaculum tepidum|Rep:
Methylenetetrahydrofolate dehydrogenase - Chlorobium
tepidum
Length = 296
Score = 37.9 bits (84), Expect = 0.21
Identities = 25/84 (29%), Positives = 41/84 (48%), Gaps = 8/84 (9%)
Frame = +2
Query: 281 AKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVAVGD--- 451
A + + N +VHGI V P+ D DA + D +SP KDV+GL+ ++ +
Sbjct: 71 ATLEAANRDSAVHGIFVYYPIWGDKR-DAE-LRDLISPHKDVEGLSPHWIKKLYANERFD 128
Query: 452 -----LSGFIPCTPAGCVELIKKT 508
+PCTP ++L++ T
Sbjct: 129 DTERRFKSILPCTPLAIIKLLEVT 152
>UniRef50_Q4QBW1 Cluster: Methylenetetrahydrofolate
dehydrogenase-like protein; n=2; Leishmania|Rep:
Methylenetetrahydrofolate dehydrogenase-like protein -
Leishmania major
Length = 207
Score = 37.9 bits (84), Expect = 0.21
Identities = 20/66 (30%), Positives = 35/66 (53%)
Frame = +2
Query: 236 RTYPLTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGL 415
R L+ + +IEL + ++N+ V +++Q+PL + V + P KDVDGL
Sbjct: 91 RLVHLSATVQQIELHRTLAAVNDDVEVDAVLLQLPLPPHQRTRSALV--HIHPGKDVDGL 148
Query: 416 NTINEG 433
+ +N G
Sbjct: 149 HPLNAG 154
>UniRef50_Q4VDG8 Cluster: Putative methylene tetrahydrofolate
dehydrogenase; n=1; Hyaloperonospora parasitica|Rep:
Putative methylene tetrahydrofolate dehydrogenase -
Hyaloperonospora parasitica
Length = 328
Score = 37.5 bits (83), Expect = 0.28
Identities = 29/97 (29%), Positives = 46/97 (47%), Gaps = 14/97 (14%)
Frame = +2
Query: 254 RDITEIELLAKITSLNESPSVHGIIVQMPLDSDH------AIDAHRVTDAVSPDKDVDGL 415
R++ + +LLA + NE P VHGI+V P +D + D++S KDV+GL
Sbjct: 79 REVPKDDLLAALQQANEDPDVHGILVYYPCFGTFPSFFGGTMDDF-LRDSISIKKDVEGL 137
Query: 416 NTINEGRV-----AVGD---LSGFIPCTPAGCVELIK 502
G + V D +PCTP V++++
Sbjct: 138 GQFYRGNLYRNIRYVDDEKTQKCVLPCTPLAIVKILE 174
>UniRef50_Q98QV3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma pulmonis|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma pulmonis
Length = 272
Score = 37.1 bits (82), Expect = 0.37
Identities = 16/40 (40%), Positives = 26/40 (65%)
Frame = +1
Query: 508 RVTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKT 627
++++ K V V+G+SR+VG P+S+ LK +A V V T
Sbjct: 146 KISVENKKVFVVGQSRLVGKPISQFLKNNNAIVRVFDKST 185
Score = 32.7 bits (71), Expect = 7.9
Identities = 17/56 (30%), Positives = 34/56 (60%), Gaps = 3/56 (5%)
Frame = +3
Query: 81 IENDLRQ-QVTRLRSKWSGFEPRL--AIVQVGGREDSNVYIRMKLKAAEKIGIAAE 239
+ N+L Q + L+ K+S + ++ AIV +G S +Y++ K++ A+ IG+ A+
Sbjct: 6 LSNELVQIKRAELKEKFSKLDQKVKFAIVLIGDNASSKIYVKKKIEFAQDIGVEAK 61
>UniRef50_A6NP56 Cluster: Uncharacterized protein ENSP00000372121;
n=5; Eutheria|Rep: Uncharacterized protein
ENSP00000372121 - Homo sapiens (Human)
Length = 200
Score = 35.5 bits (78), Expect = 1.1
Identities = 20/65 (30%), Positives = 37/65 (56%)
Frame = +3
Query: 45 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 224
A +ISG ++A I+ ++RQ+V + P L+++ VG S+ Y+ K +AA +
Sbjct: 37 AVVISGRKLAQQIKQEVRQEVEEWVAS-GDKRPHLSMILVGESSASHSYVLNKTRAAADV 95
Query: 225 GIAAE 239
GI ++
Sbjct: 96 GINSD 100
>UniRef50_UPI0000D9D4E1 Cluster: PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor; n=2; Catarrhini|Rep: PREDICTED:
similar to Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor -
Macaca mulatta
Length = 111
Score = 35.1 bits (77), Expect = 1.5
Identities = 19/62 (30%), Positives = 35/62 (56%)
Frame = +3
Query: 45 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 224
A +ISG ++A I+ ++RQ+V + P L+++ VG S+ Y+ K +AA +
Sbjct: 37 AVVISGRKLAQEIKQEVRQEVEEWVAS-GNKRPHLSVILVGENPASHSYVLNKTRAAADV 95
Query: 225 GI 230
G+
Sbjct: 96 GM 97
>UniRef50_Q4DH06 Cluster: Methylenetetrahydrofolate
dehydrogenase-like protein, putative; n=1; Trypanosoma
cruzi|Rep: Methylenetetrahydrofolate dehydrogenase-like
protein, putative - Trypanosoma cruzi
Length = 375
Score = 34.3 bits (75), Expect = 2.6
Identities = 17/62 (27%), Positives = 34/62 (54%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L ++E L ++ +++ + G+++Q+P+ S + + + P KDVDGL+ IN
Sbjct: 66 LPETVSEERLHQELRRISDDNAFDGVLLQLPIPSHLRVRPALL--CIHPGKDVDGLHPIN 123
Query: 428 EG 433
G
Sbjct: 124 AG 125
>UniRef50_Q5KEZ0 Cluster: Methylenetetrahydrofolate dehydrogenase
(NAD+), putative; n=1; Filobasidiella neoformans|Rep:
Methylenetetrahydrofolate dehydrogenase (NAD+), putative
- Cryptococcus neoformans (Filobasidiella neoformans)
Length = 367
Score = 34.3 bits (75), Expect = 2.6
Identities = 20/50 (40%), Positives = 27/50 (54%)
Frame = +2
Query: 269 IELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLN 418
IE+ I NE P V G++V P+ D + + VSP KDV+GLN
Sbjct: 84 IEVEEAILEANEDPEVDGMMVYYPIYGGRQ-DQY-LQSVVSPQKDVEGLN 131
>UniRef50_Q89QU6 Cluster: Bll3028 protein; n=6; Proteobacteria|Rep:
Bll3028 protein - Bradyrhizobium japonicum
Length = 289
Score = 33.1 bits (72), Expect = 6.0
Identities = 20/54 (37%), Positives = 30/54 (55%), Gaps = 4/54 (7%)
Frame = +1
Query: 466 SLHSGRVRGTD*EDRVT----IAGKNVVVLGRSRIVGTPVSELLKWEHATVTVC 615
+L S R R T+ ++ T + GKN +VLG +R +G ++ L E A V VC
Sbjct: 17 ALRSRRRRATNNKEDKTMDLGLKGKNAIVLGGTRGIGRAIAATLAGEGANVAVC 70
>UniRef50_A6FY71 Cluster: Histone deacetylase superfamily protein;
n=1; Plesiocystis pacifica SIR-1|Rep: Histone
deacetylase superfamily protein - Plesiocystis pacifica
SIR-1
Length = 623
Score = 32.7 bits (71), Expect = 7.9
Identities = 21/63 (33%), Positives = 32/63 (50%), Gaps = 1/63 (1%)
Frame = +3
Query: 60 GIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDS-NVYIRMKLKAAEKIGIAA 236
G +E L + R + G+EPR+ +V GGR DS +R+ +A + G AA
Sbjct: 383 GYYTLSGVELGLERYGLLARLRDLGYEPRVEMVVDGGRRDSAGDTVRVWGRAQTREGSAA 442
Query: 237 EHI 245
EH+
Sbjct: 443 EHL 445
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 631,918,800
Number of Sequences: 1657284
Number of extensions: 12154368
Number of successful extensions: 32705
Number of sequences better than 10.0: 107
Number of HSP's better than 10.0 without gapping: 31267
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 32570
length of database: 575,637,011
effective HSP length: 97
effective length of database: 414,880,463
effective search space used: 48955894634
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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