Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fbpv0935
(649 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
J04031-1|AAA59574.1| 935|Homo sapiens MTHFD protein. 110 4e-24
BC050420-1|AAH50420.1| 935|Homo sapiens methylenetetrahydrofola... 110 4e-24
BC009806-1|AAH09806.1| 935|Homo sapiens methylenetetrahydrofola... 110 4e-24
X16396-1|CAA34431.1| 344|Homo sapiens protein ( Human mRNA for ... 75 2e-13
BC017054-1|AAH17054.2| 350|Homo sapiens methylenetetrahydrofola... 75 2e-13
BC015062-1|AAH15062.1| 248|Homo sapiens methylenetetrahydrofola... 75 2e-13
BC001548-1|AAH01548.1| 344|Homo sapiens methylene tetrahydrofol... 75 2e-13
AK223041-1|BAD96761.1| 344|Homo sapiens methylene tetrahydrofol... 75 2e-13
AK222826-1|BAD96546.1| 344|Homo sapiens methylene tetrahydrofol... 75 2e-13
AC073263-5|AAX93061.1| 344|Homo sapiens unknown protein. 75 2e-13
BC032771-1|AAH32771.1| 146|Homo sapiens MTHFD2L protein protein. 57 6e-08
AL049694-4|CAI95775.1| 331|Homo sapiens methylenetetrahydrofola... 53 1e-06
AL035086-8|CAI42795.1| 331|Homo sapiens methylenetetrahydrofola... 53 1e-06
BC110319-1|AAI10320.1| 900|Homo sapiens MTHFD1L protein protein. 52 1e-06
AY374131-1|AAQ82697.1| 275|Homo sapiens truncated C1-tetrahydro... 52 1e-06
AY374130-1|AAQ82696.1| 978|Homo sapiens C1-tetrahydrofolate syn... 52 1e-06
AL133260-2|CAI95678.1| 978|Homo sapiens methylenetetrahydrofola... 52 1e-06
AL117452-1|CAB55934.1| 917|Homo sapiens hypothetical protein pr... 52 1e-06
AL049694-3|CAI95774.1| 978|Homo sapiens methylenetetrahydrofola... 52 1e-06
AL035086-7|CAI42794.1| 978|Homo sapiens methylenetetrahydrofola... 52 1e-06
AL035086-6|CAI42793.1| 114|Homo sapiens methylenetetrahydrofola... 52 1e-06
AB127387-1|BAD93193.1| 978|Homo sapiens mitochondrial C1-tetrah... 52 1e-06
AK023167-1|BAB14441.1| 236|Homo sapiens ohydrolase (EC 1.5.1.15... 43 8e-04
AL035086-5|CAI42791.1| 120|Homo sapiens methylenetetrahydrofola... 38 0.041
AL035086-4|CAI42792.1| 120|Homo sapiens methylenetetrahydrofola... 37 0.054
BC037529-1|AAH37529.2| 106|Homo sapiens MTHFD2L protein protein. 36 0.094
AF334585-1|AAK01445.1| 1349|Homo sapiens NIR3 protein. 31 4.7
AB040890-1|BAA95981.2| 1359|Homo sapiens KIAA1457 protein protein. 31 4.7
>J04031-1|AAA59574.1| 935|Homo sapiens MTHFD protein.
Length = 935
Score = 110 bits (265), Expect = 4e-24
Identities = 51/88 (57%), Positives = 69/88 (78%), Gaps = 1/88 (1%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L R TE E++ ITSLNE +VHG +VQ+PLDS+++I+ V +A++P+KDVDGL +IN
Sbjct: 72 LPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKDVDGLTSIN 131
Query: 428 EGRVAVGDLSG-FIPCTPAGCVELIKKT 508
GR+A GDL+ FIPCTP GC+ELIK+T
Sbjct: 132 AGRLARGDLNDCFIPCTPKGCLELIKET 159
Score = 88.2 bits (209), Expect = 2e-17
Identities = 41/73 (56%), Positives = 57/73 (78%)
Frame = +3
Query: 45 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 224
A+I++G E++ I L+ QVT+L+ + GF PRLAI+QVG R+DSN+YI +KLKAAE+I
Sbjct: 4 AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63
Query: 225 GIAAEHIRLPGTS 263
GI A HI+LP T+
Sbjct: 64 GIKATHIKLPRTT 76
Score = 63.3 bits (147), Expect = 7e-10
Identities = 28/47 (59%), Positives = 36/47 (76%)
Frame = +1
Query: 502 EDRVTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSE 642
E V IAG++ VV+GRS+IVG P+ +LL W +ATVT CHSKT +L E
Sbjct: 158 ETGVPIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTAHLDE 204
>BC050420-1|AAH50420.1| 935|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1, methenyltetrahydro
protein.
Length = 935
Score = 110 bits (265), Expect = 4e-24
Identities = 51/88 (57%), Positives = 69/88 (78%), Gaps = 1/88 (1%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L R TE E++ ITSLNE +VHG +VQ+PLDS+++I+ V +A++P+KDVDGL +IN
Sbjct: 72 LPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKDVDGLTSIN 131
Query: 428 EGRVAVGDLSG-FIPCTPAGCVELIKKT 508
GR+A GDL+ FIPCTP GC+ELIK+T
Sbjct: 132 AGRLARGDLNDCFIPCTPKGCLELIKET 159
Score = 88.2 bits (209), Expect = 2e-17
Identities = 41/73 (56%), Positives = 57/73 (78%)
Frame = +3
Query: 45 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 224
A+I++G E++ I L+ QVT+L+ + GF PRLAI+QVG R+DSN+YI +KLKAAE+I
Sbjct: 4 AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63
Query: 225 GIAAEHIRLPGTS 263
GI A HI+LP T+
Sbjct: 64 GIKATHIKLPRTT 76
Score = 63.3 bits (147), Expect = 7e-10
Identities = 28/47 (59%), Positives = 36/47 (76%)
Frame = +1
Query: 502 EDRVTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSE 642
E V IAG++ VV+GRS+IVG P+ +LL W +ATVT CHSKT +L E
Sbjct: 158 ETGVPIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTAHLDE 204
>BC009806-1|AAH09806.1| 935|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1, methenyltetrahydro
protein.
Length = 935
Score = 110 bits (265), Expect = 4e-24
Identities = 51/88 (57%), Positives = 69/88 (78%), Gaps = 1/88 (1%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L R TE E++ ITSLNE +VHG +VQ+PLDS+++I+ V +A++P+KDVDGL +IN
Sbjct: 72 LPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKDVDGLTSIN 131
Query: 428 EGRVAVGDLSG-FIPCTPAGCVELIKKT 508
GR+A GDL+ FIPCTP GC+ELIK+T
Sbjct: 132 AGRLARGDLNDCFIPCTPKGCLELIKET 159
Score = 88.2 bits (209), Expect = 2e-17
Identities = 41/73 (56%), Positives = 57/73 (78%)
Frame = +3
Query: 45 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 224
A+I++G E++ I L+ QVT+L+ + GF PRLAI+QVG R+DSN+YI +KLKAAE+I
Sbjct: 4 AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63
Query: 225 GIAAEHIRLPGTS 263
GI A HI+LP T+
Sbjct: 64 GIKATHIKLPRTT 76
Score = 63.3 bits (147), Expect = 7e-10
Identities = 28/47 (59%), Positives = 36/47 (76%)
Frame = +1
Query: 502 EDRVTIAGKNVVVLGRSRIVGTPVSELLKWEHATVTVCHSKTKNLSE 642
E V IAG++ VV+GRS+IVG P+ +LL W +ATVT CHSKT +L E
Sbjct: 158 ETGVPIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTAHLDE 204
>X16396-1|CAA34431.1| 344|Homo sapiens protein ( Human mRNA for
NAD-dependent methylene tetrahydrofolate dehydrogenase
cyclohydrolase (EC 1.5.1.15). ).
Length = 344
Score = 75.4 bits (177), Expect = 2e-13
Identities = 41/83 (49%), Positives = 55/83 (66%)
Frame = +2
Query: 260 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 439
I+E ELL I LN +V G++VQ+PL +H ID R+ +AVSPDKDVDG + IN GR+
Sbjct: 102 ISEEELLNLINKLNNDDNVDGLLVQLPLP-EH-IDERRICNAVSPDKDVDGFHVINVGRM 159
Query: 440 AVGDLSGFIPCTPAGCVELIKKT 508
+ D +P TP G E+IK+T
Sbjct: 160 CL-DQYSMLPATPWGVWEIIKRT 181
Score = 40.3 bits (90), Expect = 0.006
Identities = 23/72 (31%), Positives = 40/72 (55%)
Frame = +3
Query: 45 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 224
A +ISG ++A I+ ++RQ+V + P L+++ VG S+ Y+ K +AA +
Sbjct: 31 AVVISGRKLAQQIKQEVRQEVEEWVAS-GNKRPHLSVILVGENPASHSYVLNKTRAAAVV 89
Query: 225 GIAAEHIRLPGT 260
GI +E I P +
Sbjct: 90 GINSETIMKPAS 101
Score = 32.7 bits (71), Expect = 1.2
Identities = 20/43 (46%), Positives = 25/43 (58%), Gaps = 8/43 (18%)
Frame = +1
Query: 523 GKNVVVLGRSRIVGTPVSELLKWE--------HATVTVCHSKT 627
GKNVVV GRS+ VG P++ LL + ATVT+ H T
Sbjct: 187 GKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYT 229
>BC017054-1|AAH17054.2| 350|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 2, methenyltetrahydro
protein.
Length = 350
Score = 75.4 bits (177), Expect = 2e-13
Identities = 41/83 (49%), Positives = 55/83 (66%)
Frame = +2
Query: 260 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 439
I+E ELL I LN +V G++VQ+PL +H ID R+ +AVSPDKDVDG + IN GR+
Sbjct: 108 ISEEELLNLINKLNNDDNVDGLLVQLPLP-EH-IDERRICNAVSPDKDVDGFHVINVGRM 165
Query: 440 AVGDLSGFIPCTPAGCVELIKKT 508
+ D +P TP G E+IK+T
Sbjct: 166 CL-DQYSMLPATPWGVWEIIKRT 187
Score = 40.3 bits (90), Expect = 0.006
Identities = 23/72 (31%), Positives = 40/72 (55%)
Frame = +3
Query: 45 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 224
A +ISG ++A I+ ++RQ+V + P L+++ VG S+ Y+ K +AA +
Sbjct: 37 AVVISGRKLAQQIKQEVRQEVEEWVAS-GNKRPHLSVILVGENPASHSYVLNKTRAAAVV 95
Query: 225 GIAAEHIRLPGT 260
GI +E I P +
Sbjct: 96 GINSETIMKPAS 107
Score = 32.7 bits (71), Expect = 1.2
Identities = 20/43 (46%), Positives = 25/43 (58%), Gaps = 8/43 (18%)
Frame = +1
Query: 523 GKNVVVLGRSRIVGTPVSELLKWE--------HATVTVCHSKT 627
GKNVVV GRS+ VG P++ LL + ATVT+ H T
Sbjct: 193 GKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYT 235
>BC015062-1|AAH15062.1| 248|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 2, methenyltetrahydro
protein.
Length = 248
Score = 75.4 bits (177), Expect = 2e-13
Identities = 41/83 (49%), Positives = 55/83 (66%)
Frame = +2
Query: 260 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 439
I+E ELL I LN +V G++VQ+PL +H ID R+ +AVSPDKDVDG + IN GR+
Sbjct: 6 ISEEELLNLINKLNNDDNVDGLLVQLPLP-EH-IDERRICNAVSPDKDVDGFHVINVGRM 63
Query: 440 AVGDLSGFIPCTPAGCVELIKKT 508
+ D +P TP G E+IK+T
Sbjct: 64 CL-DQYSMLPATPWGVWEIIKRT 85
Score = 32.7 bits (71), Expect = 1.2
Identities = 20/43 (46%), Positives = 25/43 (58%), Gaps = 8/43 (18%)
Frame = +1
Query: 523 GKNVVVLGRSRIVGTPVSELLKWE--------HATVTVCHSKT 627
GKNVVV GRS+ VG P++ LL + ATVT+ H T
Sbjct: 91 GKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYT 133
>BC001548-1|AAH01548.1| 344|Homo sapiens methylene tetrahydrofolate
dehydrogenase 2, precursor protein.
Length = 344
Score = 75.4 bits (177), Expect = 2e-13
Identities = 41/83 (49%), Positives = 55/83 (66%)
Frame = +2
Query: 260 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 439
I+E ELL I LN +V G++VQ+PL +H ID R+ +AVSPDKDVDG + IN GR+
Sbjct: 102 ISEEELLNLINKLNNDDNVDGLLVQLPLP-EH-IDERRICNAVSPDKDVDGFHVINVGRM 159
Query: 440 AVGDLSGFIPCTPAGCVELIKKT 508
+ D +P TP G E+IK+T
Sbjct: 160 CL-DQYSMLPATPWGVWEIIKRT 181
Score = 40.3 bits (90), Expect = 0.006
Identities = 23/72 (31%), Positives = 40/72 (55%)
Frame = +3
Query: 45 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 224
A +ISG ++A I+ ++RQ+V + P L+++ VG S+ Y+ K +AA +
Sbjct: 31 AVVISGRKLAQQIKQEVRQEVEEWVAS-GNKRPHLSVILVGENPASHSYVLNKTRAAAVV 89
Query: 225 GIAAEHIRLPGT 260
GI +E I P +
Sbjct: 90 GINSETIMKPAS 101
Score = 32.7 bits (71), Expect = 1.2
Identities = 20/43 (46%), Positives = 25/43 (58%), Gaps = 8/43 (18%)
Frame = +1
Query: 523 GKNVVVLGRSRIVGTPVSELLKWE--------HATVTVCHSKT 627
GKNVVV GRS+ VG P++ LL + ATVT+ H T
Sbjct: 187 GKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYT 229
>AK223041-1|BAD96761.1| 344|Homo sapiens methylene tetrahydrofolate
dehydrogenase 2 precursor variant protein.
Length = 344
Score = 75.4 bits (177), Expect = 2e-13
Identities = 41/83 (49%), Positives = 55/83 (66%)
Frame = +2
Query: 260 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 439
I+E ELL I LN +V G++VQ+PL +H ID R+ +AVSPDKDVDG + IN GR+
Sbjct: 102 ISEEELLNLINKLNNDDNVDGLLVQLPLP-EH-IDERRICNAVSPDKDVDGFHVINVGRM 159
Query: 440 AVGDLSGFIPCTPAGCVELIKKT 508
+ D +P TP G E+IK+T
Sbjct: 160 CL-DQYSMLPATPWGVWEIIKRT 181
Score = 38.7 bits (86), Expect = 0.018
Identities = 23/72 (31%), Positives = 39/72 (54%)
Frame = +3
Query: 45 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 224
A +ISG ++A I+ ++RQ+V + P L+++ VG S+ Y+ K +AA
Sbjct: 31 AVVISGRKLAQQIKQEVRQEVEEWVAS-GNKRPHLSVILVGENPASHSYVLNKTRAAAVA 89
Query: 225 GIAAEHIRLPGT 260
GI +E I P +
Sbjct: 90 GINSETIMKPAS 101
Score = 32.7 bits (71), Expect = 1.2
Identities = 20/43 (46%), Positives = 25/43 (58%), Gaps = 8/43 (18%)
Frame = +1
Query: 523 GKNVVVLGRSRIVGTPVSELLKWE--------HATVTVCHSKT 627
GKNVVV GRS+ VG P++ LL + ATVT+ H T
Sbjct: 187 GKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYT 229
>AK222826-1|BAD96546.1| 344|Homo sapiens methylene tetrahydrofolate
dehydrogenase 2 precursor variant protein.
Length = 344
Score = 75.4 bits (177), Expect = 2e-13
Identities = 41/83 (49%), Positives = 55/83 (66%)
Frame = +2
Query: 260 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 439
I+E ELL I LN +V G++VQ+PL +H ID R+ +AVSPDKDVDG + IN GR+
Sbjct: 102 ISEEELLNLINKLNNDDNVDGLLVQLPLP-EH-IDERRICNAVSPDKDVDGFHVINVGRM 159
Query: 440 AVGDLSGFIPCTPAGCVELIKKT 508
+ D +P TP G E+IK+T
Sbjct: 160 CL-DQYSMLPATPWGVWEIIKRT 181
Score = 38.7 bits (86), Expect = 0.018
Identities = 22/72 (30%), Positives = 39/72 (54%)
Frame = +3
Query: 45 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 224
A +ISG ++A I+ ++RQ+V + P L+++ G S+ Y+ K +AA +
Sbjct: 31 AVVISGRKLAQQIKQEVRQEVEEWVAS-GNKRPHLSVILAGENPASHSYVLNKTRAAAVV 89
Query: 225 GIAAEHIRLPGT 260
GI +E I P +
Sbjct: 90 GINSETIMKPAS 101
Score = 32.7 bits (71), Expect = 1.2
Identities = 20/43 (46%), Positives = 25/43 (58%), Gaps = 8/43 (18%)
Frame = +1
Query: 523 GKNVVVLGRSRIVGTPVSELLKWE--------HATVTVCHSKT 627
GKNVVV GRS+ VG P++ LL + ATVT+ H T
Sbjct: 187 GKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYT 229
>AC073263-5|AAX93061.1| 344|Homo sapiens unknown protein.
Length = 344
Score = 75.4 bits (177), Expect = 2e-13
Identities = 41/83 (49%), Positives = 55/83 (66%)
Frame = +2
Query: 260 ITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRV 439
I+E ELL I LN +V G++VQ+PL +H ID R+ +AVSPDKDVDG + IN GR+
Sbjct: 102 ISEEELLNLINKLNNDDNVDGLLVQLPLP-EH-IDERRICNAVSPDKDVDGFHVINVGRM 159
Query: 440 AVGDLSGFIPCTPAGCVELIKKT 508
+ D +P TP G E+IK+T
Sbjct: 160 CL-DQYSMLPATPWGVWEIIKRT 181
Score = 40.3 bits (90), Expect = 0.006
Identities = 23/72 (31%), Positives = 40/72 (55%)
Frame = +3
Query: 45 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 224
A +ISG ++A I+ ++RQ+V + P L+++ VG S+ Y+ K +AA +
Sbjct: 31 AVVISGRKLAQQIKQEVRQEVEEWVAS-GNKRPHLSVILVGENPASHSYVLNKTRAAAVV 89
Query: 225 GIAAEHIRLPGT 260
GI +E I P +
Sbjct: 90 GINSETIMKPAS 101
Score = 32.7 bits (71), Expect = 1.2
Identities = 20/43 (46%), Positives = 25/43 (58%), Gaps = 8/43 (18%)
Frame = +1
Query: 523 GKNVVVLGRSRIVGTPVSELLKWE--------HATVTVCHSKT 627
GKNVVV GRS+ VG P++ LL + ATVT+ H T
Sbjct: 187 GKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYT 229
>BC032771-1|AAH32771.1| 146|Homo sapiens MTHFD2L protein protein.
Length = 146
Score = 56.8 bits (131), Expect = 6e-08
Identities = 29/67 (43%), Positives = 43/67 (64%)
Frame = +2
Query: 308 PSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINEGRVAVGDLSGFIPCTPAGC 487
P V GI+VQ+PL DH +D + + ++P+KDVDG + IN GR+ + D IP T +
Sbjct: 3 PRVSGILVQLPLP-DH-VDERTICNGIAPEKDVDGFHIINIGRLCL-DQHSLIPATASAV 59
Query: 488 VELIKKT 508
E+IK+T
Sbjct: 60 WEIIKRT 66
Score = 34.3 bits (75), Expect = 0.38
Identities = 22/43 (51%), Positives = 26/43 (60%), Gaps = 8/43 (18%)
Frame = +1
Query: 523 GKNVVVLGRSRIVGTPVSELL--KWEH------ATVTVCHSKT 627
GKNVVV GRS+ VG P++ LL EH ATVT+ H T
Sbjct: 72 GKNVVVAGRSKNVGMPIAMLLHTDGEHERPGGDATVTIAHRYT 114
>AL049694-4|CAI95775.1| 331|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 331
Score = 52.8 bits (121), Expect = 1e-06
Identities = 28/91 (30%), Positives = 52/91 (57%), Gaps = 1/91 (1%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L D +E E++ +I +NE VHG+ +Q+ + +++V +A+ P+KDVDG+ IN
Sbjct: 90 LPPDSSEAEIIDEILKINEDTRVHGLALQI----SENLFSNKVLNALKPEKDVDGVTDIN 145
Query: 428 EGRVAVGDL-SGFIPCTPAGCVELIKKTASL 517
G++ GD F+ +EL++K+ +
Sbjct: 146 LGKLVRGDAHECFVSPVAKAVIELLEKSVGV 176
Score = 32.7 bits (71), Expect = 1.2
Identities = 21/61 (34%), Positives = 33/61 (54%)
Frame = +3
Query: 81 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPGT 260
I+N ++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP
Sbjct: 38 IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 93
Query: 261 S 263
S
Sbjct: 94 S 94
>AL035086-8|CAI42795.1| 331|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 331
Score = 52.8 bits (121), Expect = 1e-06
Identities = 28/91 (30%), Positives = 52/91 (57%), Gaps = 1/91 (1%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L D +E E++ +I +NE VHG+ +Q+ + +++V +A+ P+KDVDG+ IN
Sbjct: 90 LPPDSSEAEIIDEILKINEDTRVHGLALQI----SENLFSNKVLNALKPEKDVDGVTDIN 145
Query: 428 EGRVAVGDL-SGFIPCTPAGCVELIKKTASL 517
G++ GD F+ +EL++K+ +
Sbjct: 146 LGKLVRGDAHECFVSPVAKAVIELLEKSVGV 176
Score = 32.7 bits (71), Expect = 1.2
Identities = 21/61 (34%), Positives = 33/61 (54%)
Frame = +3
Query: 81 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPGT 260
I+N ++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP
Sbjct: 38 IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 93
Query: 261 S 263
S
Sbjct: 94 S 94
>BC110319-1|AAI10320.1| 900|Homo sapiens MTHFD1L protein protein.
Length = 900
Score = 52.4 bits (120), Expect = 1e-06
Identities = 28/88 (31%), Positives = 51/88 (57%), Gaps = 1/88 (1%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L D +E E++ +I +NE VHG+ +Q+ + +++V +A+ P+KDVDG+ IN
Sbjct: 53 LPPDSSEAEIIDEILKINEDTRVHGLALQI----SENLFSNKVLNALKPEKDVDGVTDIN 108
Query: 428 EGRVAVGDL-SGFIPCTPAGCVELIKKT 508
G++ GD F+ +EL++K+
Sbjct: 109 LGKLVRGDAHECFVSPVAKAVIELLEKS 136
Score = 32.3 bits (70), Expect = 1.5
Identities = 19/56 (33%), Positives = 30/56 (53%)
Frame = +3
Query: 96 RQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPGTS 263
++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP S
Sbjct: 5 KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPDS 57
>AY374131-1|AAQ82697.1| 275|Homo sapiens truncated
C1-tetrahydrofolate synthase protein.
Length = 275
Score = 52.4 bits (120), Expect = 1e-06
Identities = 28/88 (31%), Positives = 51/88 (57%), Gaps = 1/88 (1%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L D +E E++ +I +NE VHG+ +Q+ + +++V +A+ P+KDVDG+ IN
Sbjct: 131 LPPDSSEAEIIDEILKINEDTRVHGLALQI----SENLFSNKVLNALKPEKDVDGVTDIN 186
Query: 428 EGRVAVGDL-SGFIPCTPAGCVELIKKT 508
G++ GD F+ +EL++K+
Sbjct: 187 LGKLVRGDAHECFVSPVAKAVIELLEKS 214
Score = 32.7 bits (71), Expect = 1.2
Identities = 21/61 (34%), Positives = 33/61 (54%)
Frame = +3
Query: 81 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPGT 260
I+N ++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP
Sbjct: 79 IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 134
Query: 261 S 263
S
Sbjct: 135 S 135
>AY374130-1|AAQ82696.1| 978|Homo sapiens C1-tetrahydrofolate
synthase protein.
Length = 978
Score = 52.4 bits (120), Expect = 1e-06
Identities = 28/88 (31%), Positives = 51/88 (57%), Gaps = 1/88 (1%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L D +E E++ +I +NE VHG+ +Q+ + +++V +A+ P+KDVDG+ IN
Sbjct: 131 LPPDSSEAEIIDEILKINEDTRVHGLALQI----SENLFSNKVLNALKPEKDVDGVTDIN 186
Query: 428 EGRVAVGDL-SGFIPCTPAGCVELIKKT 508
G++ GD F+ +EL++K+
Sbjct: 187 LGKLVRGDAHECFVSPVAKAVIELLEKS 214
Score = 32.7 bits (71), Expect = 1.2
Identities = 21/61 (34%), Positives = 33/61 (54%)
Frame = +3
Query: 81 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPGT 260
I+N ++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP
Sbjct: 79 IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 134
Query: 261 S 263
S
Sbjct: 135 S 135
>AL133260-2|CAI95678.1| 978|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 978
Score = 52.4 bits (120), Expect = 1e-06
Identities = 28/88 (31%), Positives = 51/88 (57%), Gaps = 1/88 (1%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L D +E E++ +I +NE VHG+ +Q+ + +++V +A+ P+KDVDG+ IN
Sbjct: 131 LPPDSSEAEIIDEILKINEDTRVHGLALQI----SENLFSNKVLNALKPEKDVDGVTDIN 186
Query: 428 EGRVAVGDL-SGFIPCTPAGCVELIKKT 508
G++ GD F+ +EL++K+
Sbjct: 187 LGKLVRGDAHECFVSPVAKAVIELLEKS 214
Score = 32.7 bits (71), Expect = 1.2
Identities = 21/61 (34%), Positives = 33/61 (54%)
Frame = +3
Query: 81 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPGT 260
I+N ++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP
Sbjct: 79 IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 134
Query: 261 S 263
S
Sbjct: 135 S 135
>AL117452-1|CAB55934.1| 917|Homo sapiens hypothetical protein
protein.
Length = 917
Score = 52.4 bits (120), Expect = 1e-06
Identities = 28/88 (31%), Positives = 51/88 (57%), Gaps = 1/88 (1%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L D +E E++ +I +NE VHG+ +Q+ + +++V +A+ P+KDVDG+ IN
Sbjct: 70 LPPDSSEAEIIDEILKINEDTRVHGLALQI----SENLFSNKVLNALKPEKDVDGVTDIN 125
Query: 428 EGRVAVGDL-SGFIPCTPAGCVELIKKT 508
G++ GD F+ +EL++K+
Sbjct: 126 LGKLVRGDAHECFVSPVAKAVIELLEKS 153
Score = 32.7 bits (71), Expect = 1.2
Identities = 21/61 (34%), Positives = 33/61 (54%)
Frame = +3
Query: 81 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPGT 260
I+N ++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP
Sbjct: 18 IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 73
Query: 261 S 263
S
Sbjct: 74 S 74
>AL049694-3|CAI95774.1| 978|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 978
Score = 52.4 bits (120), Expect = 1e-06
Identities = 28/88 (31%), Positives = 51/88 (57%), Gaps = 1/88 (1%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L D +E E++ +I +NE VHG+ +Q+ + +++V +A+ P+KDVDG+ IN
Sbjct: 131 LPPDSSEAEIIDEILKINEDTRVHGLALQI----SENLFSNKVLNALKPEKDVDGVTDIN 186
Query: 428 EGRVAVGDL-SGFIPCTPAGCVELIKKT 508
G++ GD F+ +EL++K+
Sbjct: 187 LGKLVRGDAHECFVSPVAKAVIELLEKS 214
Score = 32.7 bits (71), Expect = 1.2
Identities = 21/61 (34%), Positives = 33/61 (54%)
Frame = +3
Query: 81 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPGT 260
I+N ++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP
Sbjct: 79 IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 134
Query: 261 S 263
S
Sbjct: 135 S 135
>AL035086-7|CAI42794.1| 978|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 978
Score = 52.4 bits (120), Expect = 1e-06
Identities = 28/88 (31%), Positives = 51/88 (57%), Gaps = 1/88 (1%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L D +E E++ +I +NE VHG+ +Q+ + +++V +A+ P+KDVDG+ IN
Sbjct: 131 LPPDSSEAEIIDEILKINEDTRVHGLALQI----SENLFSNKVLNALKPEKDVDGVTDIN 186
Query: 428 EGRVAVGDL-SGFIPCTPAGCVELIKKT 508
G++ GD F+ +EL++K+
Sbjct: 187 LGKLVRGDAHECFVSPVAKAVIELLEKS 214
Score = 32.7 bits (71), Expect = 1.2
Identities = 21/61 (34%), Positives = 33/61 (54%)
Frame = +3
Query: 81 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPGT 260
I+N ++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP
Sbjct: 79 IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 134
Query: 261 S 263
S
Sbjct: 135 S 135
>AL035086-6|CAI42793.1| 114|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 114
Score = 52.4 bits (120), Expect = 1e-06
Identities = 28/88 (31%), Positives = 51/88 (57%), Gaps = 1/88 (1%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L D +E E++ +I +NE VHG+ +Q+ + +++V +A+ P+KDVDG+ IN
Sbjct: 21 LPPDSSEAEIIDEILKINEDTRVHGLALQI----SENLFSNKVLNALKPEKDVDGVTDIN 76
Query: 428 EGRVAVGDL-SGFIPCTPAGCVELIKKT 508
G++ GD F+ +EL++K+
Sbjct: 77 LGKLVRGDAHECFVSPVAKAVIELLEKS 104
>AB127387-1|BAD93193.1| 978|Homo sapiens mitochondrial
C1-tetrahydrofolate synthetase protein.
Length = 978
Score = 52.4 bits (120), Expect = 1e-06
Identities = 28/88 (31%), Positives = 51/88 (57%), Gaps = 1/88 (1%)
Frame = +2
Query: 248 LTRDITEIELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 427
L D +E E++ +I +NE VHG+ +Q+ + +++V +A+ P+KDVDG+ IN
Sbjct: 131 LPPDSSEAEIIDEILKINEDTRVHGLALQI----SENLFSNKVLNALKPEKDVDGVTDIN 186
Query: 428 EGRVAVGDL-SGFIPCTPAGCVELIKKT 508
G++ GD F+ +EL++K+
Sbjct: 187 LGKLVRGDAHECFVSPVAKAVIELLEKS 214
Score = 32.7 bits (71), Expect = 1.2
Identities = 21/61 (34%), Positives = 33/61 (54%)
Frame = +3
Query: 81 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPGT 260
I+N ++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP
Sbjct: 79 IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 134
Query: 261 S 263
S
Sbjct: 135 S 135
>AK023167-1|BAB14441.1| 236|Homo sapiens ohydrolase (EC 1.5.1.15).
protein.
Length = 236
Score = 43.2 bits (97), Expect = 8e-04
Identities = 19/50 (38%), Positives = 31/50 (62%)
Frame = +2
Query: 359 IDAHRVTDAVSPDKDVDGLNTINEGRVAVGDLSGFIPCTPAGCVELIKKT 508
+D + + ++P+KDVDG + IN GR+ + D IP T + E+IK+T
Sbjct: 42 VDERTICNGIAPEKDVDGFHIINIGRLCL-DQHSLIPATASAVWEIIKRT 90
Score = 34.3 bits (75), Expect = 0.38
Identities = 22/43 (51%), Positives = 26/43 (60%), Gaps = 8/43 (18%)
Frame = +1
Query: 523 GKNVVVLGRSRIVGTPVSELL--KWEH------ATVTVCHSKT 627
GKNVVV GRS+ VG P++ LL EH ATVT+ H T
Sbjct: 96 GKNVVVAGRSKNVGMPIAMLLHTDGEHERPGGDATVTIAHRYT 138
>AL035086-5|CAI42791.1| 120|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 120
Score = 37.5 bits (83), Expect = 0.041
Identities = 17/52 (32%), Positives = 32/52 (61%), Gaps = 1/52 (1%)
Frame = +2
Query: 365 AHRVTDAVSPDKDVDGLNTINEGRVAVGDL-SGFIPCTPAGCVELIKKTASL 517
+++V +A+ P+KDVDG+ IN G++ GD F+ +EL++K+ +
Sbjct: 10 SNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSVGV 61
>AL035086-4|CAI42792.1| 120|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 120
Score = 37.1 bits (82), Expect = 0.054
Identities = 17/49 (34%), Positives = 31/49 (63%), Gaps = 1/49 (2%)
Frame = +2
Query: 365 AHRVTDAVSPDKDVDGLNTINEGRVAVGDL-SGFIPCTPAGCVELIKKT 508
+++V +A+ P+KDVDG+ IN G++ GD F+ +EL++K+
Sbjct: 11 SNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLEKS 59
>BC037529-1|AAH37529.2| 106|Homo sapiens MTHFD2L protein protein.
Length = 106
Score = 36.3 bits (80), Expect = 0.094
Identities = 16/38 (42%), Positives = 24/38 (63%)
Frame = +3
Query: 141 PRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLP 254
P L+I+ VG S+ Y+R K++AA +GI +E I P
Sbjct: 24 PHLSIILVGDNPASHTYVRNKIRAASAVGICSELILKP 61
Score = 31.9 bits (69), Expect = 2.0
Identities = 14/30 (46%), Positives = 20/30 (66%)
Frame = +2
Query: 254 RDITEIELLAKITSLNESPSVHGIIVQMPL 343
+D+++ ELL LN P V GI+VQ+PL
Sbjct: 62 KDVSQEELLDVTDQLNMDPRVSGILVQLPL 91
>AF334585-1|AAK01445.1| 1349|Homo sapiens NIR3 protein.
Length = 1349
Score = 30.7 bits (66), Expect = 4.7
Identities = 24/81 (29%), Positives = 38/81 (46%), Gaps = 6/81 (7%)
Frame = +2
Query: 218 ENWYRRRTYPLTRDITEIELLAKITSLNESPSV-HGIIVQMPLD----SDHAIDAHRVTD 382
E W R+RT+ R++T + + + P V G + PLD + +D H +T
Sbjct: 987 EKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPLDMVTLTGEKVDVHIMTQ 1046
Query: 383 AVSPD-KDVDGLNTINEGRVA 442
S + +D L T N GRV+
Sbjct: 1047 PPSGEWLYLDTLVTNNSGRVS 1067
>AB040890-1|BAA95981.2| 1359|Homo sapiens KIAA1457 protein protein.
Length = 1359
Score = 30.7 bits (66), Expect = 4.7
Identities = 24/81 (29%), Positives = 38/81 (46%), Gaps = 6/81 (7%)
Frame = +2
Query: 218 ENWYRRRTYPLTRDITEIELLAKITSLNESPSV-HGIIVQMPLD----SDHAIDAHRVTD 382
E W R+RT+ R++T + + + P V G + PLD + +D H +T
Sbjct: 997 EKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPLDMVTLTGEKVDVHIMTQ 1056
Query: 383 AVSPD-KDVDGLNTINEGRVA 442
S + +D L T N GRV+
Sbjct: 1057 PPSGEWLYLDTLVTNNSGRVS 1077
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 91,425,370
Number of Sequences: 237096
Number of extensions: 1844858
Number of successful extensions: 5450
Number of sequences better than 10.0: 28
Number of HSP's better than 10.0 without gapping: 5205
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5418
length of database: 76,859,062
effective HSP length: 87
effective length of database: 56,231,710
effective search space used: 7197658880
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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