Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fbpv0637
(870 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P31939 Cluster: Bifunctional purine biosynthesis protei... 162 9e-39
UniRef50_Q4SHT8 Cluster: Chromosome 5 SCAF14581, whole genome sh... 158 1e-37
UniRef50_Q73LG8 Cluster: Phosphoribosylaminoimidazolecarboxamide... 103 4e-21
UniRef50_P74741 Cluster: Bifunctional purine biosynthesis protei... 101 2e-20
UniRef50_P67543 Cluster: Bifunctional purine biosynthesis protei... 99 2e-19
UniRef50_Q550I9 Cluster: AICAR transformylase / IMP cyclohydrola... 98 3e-19
UniRef50_P43852 Cluster: Bifunctional purine biosynthesis protei... 97 7e-19
UniRef50_A6G003 Cluster: Bifunctional phosphoribosylaminoimidazo... 94 4e-18
UniRef50_Q8ZAR3 Cluster: Bifunctional purine biosynthesis protei... 93 1e-17
UniRef50_A1K9K5 Cluster: Phosphoribosylaminoimidazolecarboxamide... 92 2e-17
UniRef50_Q8F3W6 Cluster: Bifunctional purine biosynthesis protei... 90 6e-17
UniRef50_Q2JI00 Cluster: Bifunctional purine biosynthesis protei... 90 8e-17
UniRef50_Q2JR47 Cluster: Bifunctional purine biosynthesis protei... 89 1e-16
UniRef50_Q8PYG4 Cluster: Formyltransferase phosphoribosylaminoim... 89 1e-16
UniRef50_Q9F1T4 Cluster: Bifunctional purine biosynthesis protei... 88 2e-16
UniRef50_Q8CXK7 Cluster: Bifunctional purine biosynthesis protei... 88 2e-16
UniRef50_P12048 Cluster: Bifunctional purine biosynthesis protei... 85 2e-15
UniRef50_Q83EI4 Cluster: Phosphoribosylaminoimidazolecarboxamide... 84 5e-15
UniRef50_Q6L122 Cluster: Phosphoribosylaminoimidazolecarboxamide... 83 7e-15
UniRef50_Q9PC10 Cluster: Bifunctional purine biosynthesis protei... 83 7e-15
UniRef50_Q1V178 Cluster: Bifunctional purine biosynthesis protei... 83 9e-15
UniRef50_Q9FPL3 Cluster: Phosphoribosylaminoimidazolecarboxamide... 83 1e-14
UniRef50_Q7X311 Cluster: Putative AICAR transformylase; n=1; unc... 81 5e-14
UniRef50_A5E8X1 Cluster: Phosphoribosylaminoimidazolecarboxamide... 79 2e-13
UniRef50_A0JTW4 Cluster: Phosphoribosylaminoimidazolecarboxamide... 79 2e-13
UniRef50_Q8XMK2 Cluster: Bifunctional purine biosynthesis protei... 79 2e-13
UniRef50_O67775 Cluster: Bifunctional purine biosynthesis protei... 79 2e-13
UniRef50_A7HM64 Cluster: IMP cyclohydrolase; n=1; Fervidobacteri... 77 4e-13
UniRef50_Q8A155 Cluster: Bifunctional purine biosynthesis protei... 77 6e-13
UniRef50_Q9RW01 Cluster: Bifunctional purine biosynthesis protei... 76 1e-12
UniRef50_Q7MUT5 Cluster: Phosphoribosylaminoimidazolecarboxamide... 76 1e-12
UniRef50_A7DF55 Cluster: Phosphoribosylaminoimidazolecarboxamide... 76 1e-12
UniRef50_UPI00015BCE7E Cluster: UPI00015BCE7E related cluster; n... 75 2e-12
UniRef50_A1IEQ8 Cluster: IMP cyclohydrolase; n=1; Candidatus Des... 73 1e-11
UniRef50_A2SS05 Cluster: Phosphoribosylaminoimidazolecarboxamide... 73 1e-11
UniRef50_Q8D244 Cluster: Bifunctional purine biosynthesis protei... 73 1e-11
UniRef50_A7BET6 Cluster: Putative uncharacterized protein; n=1; ... 73 1e-11
UniRef50_Q8G6B1 Cluster: Bifunctional purine biosynthesis protei... 71 3e-11
UniRef50_Q9PNY2 Cluster: Bifunctional purine biosynthesis protei... 69 1e-10
UniRef50_Q83GZ1 Cluster: Phosphoribosylaminoimidazolecarboxamide... 69 2e-10
UniRef50_A7I7L2 Cluster: Phosphoribosylaminoimidazolecarboxamide... 66 8e-10
UniRef50_Q89B23 Cluster: Bifunctional purine biosynthesis protei... 65 3e-09
UniRef50_Q316G8 Cluster: Phosphoribosylaminoimidazolecarboxamide... 62 1e-08
UniRef50_A4MAE3 Cluster: Phosphoribosylaminoimidazolecarboxamide... 62 2e-08
UniRef50_Q6MIZ2 Cluster: IMP cyclohydrolase; n=1; Bdellovibrio b... 61 3e-08
UniRef50_Q7VRP9 Cluster: Phosphoribosylaminoimidazolecarboxamide... 54 2e-07
UniRef50_A5B3D8 Cluster: DNA-directed RNA polymerase; n=1; Vitis... 52 2e-05
UniRef50_Q95QQ5 Cluster: Putative uncharacterized protein; n=2; ... 51 3e-05
UniRef50_A1G3C3 Cluster: Phosphoribosylaminoimidazolecarboxamide... 50 6e-05
UniRef50_A7PK27 Cluster: Chromosome chr15 scaffold_19, whole gen... 44 0.004
UniRef50_Q0YKD5 Cluster: IMP cyclohydrolase; n=2; Geobacter|Rep:... 44 0.007
UniRef50_Q3JNS9 Cluster: Putative uncharacterized protein; n=9; ... 43 0.009
UniRef50_A4M1L4 Cluster: Putative uncharacterized protein; n=1; ... 40 0.082
UniRef50_A1HBX2 Cluster: Putative uncharacterized protein; n=2; ... 36 1.0
UniRef50_Q4RM56 Cluster: Chromosome 10 SCAF15019, whole genome s... 36 1.8
UniRef50_A6SGW5 Cluster: Putative uncharacterized protein; n=2; ... 34 4.1
UniRef50_Q6AGB7 Cluster: Flagellar hook-associated protein 3; n=... 33 9.4
UniRef50_A5B1A5 Cluster: DNA-directed RNA polymerase; n=1; Vitis... 33 9.4
UniRef50_Q9X0X6 Cluster: Bifunctional purine biosynthesis protei... 33 9.4
>UniRef50_P31939 Cluster: Bifunctional purine biosynthesis protein
PURH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3)
(5-aminoimidazole-4-carboxamide ribonucleotide
formyltransferase) (AICAR transformylase); IMP
cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=105; cellular organisms|Rep:
Bifunctional purine biosynthesis protein PURH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3)
(5-aminoimidazole-4-carboxamide ribonucleotide
formyltransferase) (AICAR transformylase); IMP
cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Homo sapiens (Human)
Length = 592
Score = 162 bits (394), Expect = 9e-39
Identities = 97/209 (46%), Positives = 117/209 (55%), Gaps = 4/209 (1%)
Frame = +2
Query: 8 ITRAPEMLGGRVKTLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKP 187
+T PEMLGGRVKTLHPAVHAGILAR D DM R + +I VV CNLYPFV+TV+ P
Sbjct: 54 LTGFPEMLGGRVKTLHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASP 113
Query: 188 DVTVADAVENIDIGGVTLLRAXQEXXXXXXXXXXXXXXCCSQRNQREQTSSDDFGHKAEI 367
VTV +AVE IDIGGVTLLRA + + S D E
Sbjct: 114 GVTVEEAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDT---SLET 170
Query: 368 SPEGVHSYFGL*PRHIGLLPQAILARASP--TDLKIRYEPTSEAGPG-IHT-RDSLPITT 535
+ F ++ + + S + + +RY P ++T + LPIT
Sbjct: 171 RRQLALKAFTHTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITV 230
Query: 536 LNGAPGFINLCDALNAWQLVKELKEALNL 622
LNGAPGFINLCDALNAWQLVKELKEAL +
Sbjct: 231 LNGAPGFINLCDALNAWQLVKELKEALGI 259
Score = 124 bits (300), Expect = 2e-27
Identities = 75/185 (40%), Positives = 94/185 (50%), Gaps = 2/185 (1%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYF 425
A +KNH RVTVVC+P DY V E++ ++ T+L TR++LALKAFTHT+ YD AISDYF
Sbjct: 134 AAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFTHTAQYDEAISDYF 193
Query: 426 RKQYSPGQAQLTLRYGMNPHQKPAQVFTPETACRSRH*TVRLDLSTCATR*TPGXXXXXX 605
RKQYS G +Q+ LRYGMNPHQ PAQ++T +
Sbjct: 194 RKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINLCDALNAWQLVKEL 253
Query: 606 XXXXTFPAAASFQARVPCRSCRG--LATXXXXXXXXXXXXXELSXXXXXXXXXXXXDRMS 779
PAAASF+ P + G L+ L+ DRMS
Sbjct: 254 KEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPISAAYARARGADRMS 313
Query: 780 SFGDF 794
SFGDF
Sbjct: 314 SFGDF 318
Score = 48.8 bits (111), Expect = 2e-04
Identities = 20/26 (76%), Positives = 25/26 (96%)
Frame = +1
Query: 637 AFKHVSPAGAAVGLPLTDEEAAVCMV 714
+FKHVSPAGAAVG+PL+++EA VCMV
Sbjct: 264 SFKHVSPAGAAVGIPLSEDEAKVCMV 289
>UniRef50_Q4SHT8 Cluster: Chromosome 5 SCAF14581, whole genome
shotgun sequence; n=3; Euteleostomi|Rep: Chromosome 5
SCAF14581, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 628
Score = 158 bits (384), Expect = 1e-37
Identities = 96/207 (46%), Positives = 120/207 (57%), Gaps = 1/207 (0%)
Frame = +2
Query: 8 ITRAPEMLGGRVKTLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKP 187
+T PEMLGGRVKTLHPAVH GILAR S +D DM++ Y +I VVVCNLYPFV+TVS P
Sbjct: 48 LTGHPEMLGGRVKTLHPAVHGGILARKSPADTADMEKLGYSLIRVVVCNLYPFVKTVSNP 107
Query: 188 DVTVADAVENIDIGGVTLLRAXQEXXXXXXXXXXXXXXCCSQRNQREQTSSDDFGHKAEI 367
VTV DAVE IDIGGVTLLRA + + E + S D + +
Sbjct: 108 SVTVEDAVEQIDIGGVTLLRAAAKNHARVTVVCDPADY-PRVAEEMEGSGSRDTPSRTRL 166
Query: 368 SPEGVHSYFGL*PRHIGLLPQAILARASPTDLKIRYEPTSEAGPGIHT-RDSLPITTLNG 544
S R A A P+ L + +A ++T R +LP+ +NG
Sbjct: 167 ST----------TRPYRTTSGDSSAVAFPSCLCVYGMNPHQAPAQLYTLRPALPLRVVNG 216
Query: 545 APGFINLCDALNAWQLVKELKEALNLS 625
+PGFINLCDALNAWQLV+EL +AL ++
Sbjct: 217 SPGFINLCDALNAWQLVRELSKALGVA 243
Score = 54.8 bits (126), Expect = 3e-06
Identities = 53/185 (28%), Positives = 70/185 (37%), Gaps = 2/185 (1%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYF 425
A +KNH RVTVVCDPADY V +E++ + T +R RL+ T+ D + +
Sbjct: 128 AAAKNHARVTVVCDPADYPRVAEEMEGSGSRDTP--SRTRLSTTRPYRTTSGDSSAVAF- 184
Query: 426 RKQYSPGQAQLTLRYGMNPHQKPAQVFTPETACRSRH*TVRLDLSTCATR*TPGXXXXXX 605
YGMNPHQ PAQ++T A R
Sbjct: 185 --------PSCLCVYGMNPHQAPAQLYTLRPALPLRVVNGSPGFINLCDALNAWQLVREL 236
Query: 606 XXXXTFPAAASFQARVPCRSCRG--LATXXXXXXXXXXXXXELSXXXXXXXXXXXXDRMS 779
AA SF+ P + G L+ +L+ DRMS
Sbjct: 237 SKALGVAAATSFKHVSPAGAAVGVPLSEEEARVCMVHDMMKDLTPLATAYARARGSDRMS 296
Query: 780 SFGDF 794
SFGDF
Sbjct: 297 SFGDF 301
Score = 49.6 bits (113), Expect = 1e-04
Identities = 21/26 (80%), Positives = 25/26 (96%)
Frame = +1
Query: 637 AFKHVSPAGAAVGLPLTDEEAAVCMV 714
+FKHVSPAGAAVG+PL++EEA VCMV
Sbjct: 247 SFKHVSPAGAAVGVPLSEEEARVCMV 272
>UniRef50_Q73LG8 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=2; Bacteria|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Treponema
denticola
Length = 533
Score = 103 bits (248), Expect = 4e-21
Identities = 46/80 (57%), Positives = 60/80 (75%)
Frame = +2
Query: 11 TRAPEMLGGRVKTLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPD 190
T +PE+LGGRVKTLHP +H GILAR + D+ ++K + I +V+ NLYPF +T+S PD
Sbjct: 52 TSSPEILGGRVKTLHPMIHGGILARDTKEDRAELKALGFSGIDIVIANLYPFEKTISSPD 111
Query: 191 VTVADAVENIDIGGVTLLRA 250
T +D +ENIDIGGV LLRA
Sbjct: 112 STESDCIENIDIGGVALLRA 131
Score = 67.7 bits (158), Expect = 4e-10
Identities = 45/103 (43%), Positives = 60/103 (58%), Gaps = 13/103 (12%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYF 425
A +KN+ RVTV+CDPADYD V EI+ K + +L R+RLA+KAF + YD AI+ +
Sbjct: 131 AAAKNYSRVTVICDPADYDEVSSEIE--KTGEISLSLRKRLAIKAFDLCTRYDAAITSWL 188
Query: 426 R--KQYSPGQAQLT-----------LRYGMNPHQKPAQVFTPE 515
+ S G + T LRYG NPHQK A ++T E
Sbjct: 189 SGLSRLSGGIEEKTSLTLCAYPGQDLRYGENPHQK-AWLYTNE 230
>UniRef50_P74741 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=49; root|Rep: Bifunctional purine
biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Synechocystis sp. (strain PCC
6803)
Length = 511
Score = 101 bits (243), Expect = 2e-20
Identities = 49/81 (60%), Positives = 60/81 (74%), Gaps = 1/81 (1%)
Frame = +2
Query: 11 TRAPEMLGGRVKTLHPAVHAGILARLS-DSDQEDMKRQKYEMISVVVCNLYPFVQTVSKP 187
T APE+LGGRVKTLHP +H GILAR SDQ D++ + +VV NLYPF QT++KP
Sbjct: 54 TGAPEILGGRVKTLHPRIHGGILARRDLPSDQADLEANDIRPLDLVVVNLYPFEQTIAKP 113
Query: 188 DVTVADAVENIDIGGVTLLRA 250
VTVA+AVE IDIGG ++RA
Sbjct: 114 GVTVAEAVEQIDIGGPAMIRA 134
Score = 49.6 bits (113), Expect = 1e-04
Identities = 32/89 (35%), Positives = 48/89 (53%), Gaps = 8/89 (8%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYF 425
A +KN TV+ +P Y+A ++ ++E + L RQ+ A +AF T+ YD AI++YF
Sbjct: 134 ATAKNFAHTTVLTNPNQYEAYLQALQE--QGEIPLALRQQFAGEAFALTNAYDQAIANYF 191
Query: 426 -------RKQYS-PGQAQLTLRYGMNPHQ 488
Q+ G + LRYG NPHQ
Sbjct: 192 SGLSGDSANQFGLSGTLRQPLRYGENPHQ 220
>UniRef50_P67543 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=18; Staphylococcus|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Staphylococcus aureus (strain Mu50
/ ATCC 700699)
Length = 492
Score = 98.7 bits (235), Expect = 2e-19
Identities = 47/82 (57%), Positives = 60/82 (73%), Gaps = 1/82 (1%)
Frame = +2
Query: 8 ITRAPEMLGGRVKTLHPAVHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSK 184
+T PE++ GRVKTLHPAVH GILA R ++ Q ++I +VV NLYPF QTV+
Sbjct: 51 LTHFPEIMDGRVKTLHPAVHGGILADRNKPQHLNELSEQHIDLIDMVVVNLYPFQQTVAN 110
Query: 185 PDVTVADAVENIDIGGVTLLRA 250
PDVT+ +A+ENIDIGG T+LRA
Sbjct: 111 PDVTMDEAIENIDIGGPTMLRA 132
Score = 54.0 bits (124), Expect = 5e-06
Identities = 31/81 (38%), Positives = 46/81 (56%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYF 425
A +KN+ VT + PADY V+ ++ + ++ RQ L +K F HT++YD AI +F
Sbjct: 132 AAAKNYKHVTTIVHPADYHEVLTRLRNDSLDESY---RQSLMIKVFEHTAEYDEAIVRFF 188
Query: 426 RKQYSPGQAQLTLRYGMNPHQ 488
+ G + TLRYG NP Q
Sbjct: 189 K-----GDKE-TLRYGENPQQ 203
>UniRef50_Q550I9 Cluster: AICAR transformylase / IMP cyclohydrolase;
n=2; Dictyostelium discoideum|Rep: AICAR transformylase
/ IMP cyclohydrolase - Dictyostelium discoideum AX4
Length = 542
Score = 97.9 bits (233), Expect = 3e-19
Identities = 47/82 (57%), Positives = 60/82 (73%), Gaps = 1/82 (1%)
Frame = +2
Query: 8 ITRAPEMLGGRVKTLHPAVHAGILARLSDSD-QEDMKRQKYEMISVVVCNLYPFVQTVSK 184
+T PEML GRVKTLHP +H G+LAR + Q D+ + + IS+VV NLYPFV+TVSK
Sbjct: 50 VTEYPEMLDGRVKTLHPKIHGGLLARPELAHHQADLNKYNIKPISIVVVNLYPFVETVSK 109
Query: 185 PDVTVADAVENIDIGGVTLLRA 250
T+ +A+ENIDIGG TL+RA
Sbjct: 110 ESTTLEEAIENIDIGGHTLIRA 131
Score = 49.6 bits (113), Expect(2) = 6e-07
Identities = 27/67 (40%), Positives = 36/67 (53%), Gaps = 5/67 (7%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKE-----NKHHQTTLGTRQRLALKAFTHTSDYDLA 410
A SKN V ++ DP+DY + + I+ N TL R++LALKAF H YD A
Sbjct: 131 ASSKNFQNVLIIVDPSDYKWIGERIQSSTDSTNVLSSITLEERKKLALKAFQHGCSYDAA 190
Query: 411 ISDYFRK 431
+S Y K
Sbjct: 191 VSQYLSK 197
Score = 27.1 bits (57), Expect(2) = 6e-07
Identities = 12/19 (63%), Positives = 12/19 (63%)
Frame = +3
Query: 462 LRYGMNPHQKPAQVFTPET 518
LRYG NPHQK A P T
Sbjct: 235 LRYGENPHQKAALYQCPGT 253
>UniRef50_P43852 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=88; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Haemophilus influenzae
Length = 532
Score = 96.7 bits (230), Expect = 7e-19
Identities = 48/80 (60%), Positives = 58/80 (72%)
Frame = +2
Query: 11 TRAPEMLGGRVKTLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPD 190
T PEM+ GRVKTLHP VH GIL R +D M++ E I +VV NLYPF TV+KPD
Sbjct: 57 TGFPEMMDGRVKTLHPKVHGGILGRRG-TDDAIMQQHGIEGIDMVVVNLYPFAATVAKPD 115
Query: 191 VTVADAVENIDIGGVTLLRA 250
T+ADAVENIDIGG T++R+
Sbjct: 116 CTLADAVENIDIGGPTMVRS 135
Score = 51.2 bits (117), Expect = 3e-05
Identities = 24/64 (37%), Positives = 41/64 (64%)
Frame = +3
Query: 252 SKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYFRK 431
+KNH V +V + D++A++ E+ ++++ T TR LA+KAF HT+ YD I++YF +
Sbjct: 137 AKNHKDVAIVVNNHDFNAILAEMDQHQN-SLTFETRFDLAIKAFEHTAQYDSMIANYFGQ 195
Query: 432 QYSP 443
P
Sbjct: 196 LVKP 199
>UniRef50_A6G003 Cluster: Bifunctional
phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=1; Plesiocystis
pacifica SIR-1|Rep: Bifunctional
phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Plesiocystis
pacifica SIR-1
Length = 543
Score = 94.3 bits (224), Expect = 4e-18
Identities = 42/80 (52%), Positives = 59/80 (73%)
Frame = +2
Query: 11 TRAPEMLGGRVKTLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPD 190
T APE+L GRVKTLHP +H GILA +++ Q +++ I +V+ NLYPF +T++KP
Sbjct: 65 TGAPEILDGRVKTLHPKIHGGILALPTEAHQRELELHDIAPIDLVIVNLYPFRETIAKPG 124
Query: 191 VTVADAVENIDIGGVTLLRA 250
+ ADA+ENIDIGG T++RA
Sbjct: 125 CSFADAIENIDIGGPTMVRA 144
Score = 50.4 bits (115), Expect = 6e-05
Identities = 32/98 (32%), Positives = 49/98 (50%), Gaps = 16/98 (16%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYF 425
A +KN +RV V+ DP DY ++ + + E + R+ +A KAF HT+ YD AI+ Y
Sbjct: 144 AAAKNWNRVAVIVDPEDYSSLSEVLGETEGTLPE-SFRRNMARKAFAHTAAYDAAIASYL 202
Query: 426 RKQ----------------YSPGQAQLTLRYGMNPHQK 491
+ + G++ LRYG NPHQ+
Sbjct: 203 ARHDDAGEALDAGTIPEGLFVSGESVAELRYGENPHQQ 240
>UniRef50_Q8ZAR3 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=59; Proteobacteria|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Yersinia pestis
Length = 529
Score = 92.7 bits (220), Expect = 1e-17
Identities = 45/80 (56%), Positives = 56/80 (70%)
Frame = +2
Query: 11 TRAPEMLGGRVKTLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPD 190
T PEM+ GRVKTLHP VH GIL R D M + + I +VV NLYPF QTV++PD
Sbjct: 58 TGFPEMMDGRVKTLHPKVHGGILGRRGQDDGI-MAQHGIQPIDIVVVNLYPFAQTVARPD 116
Query: 191 VTVADAVENIDIGGVTLLRA 250
++ DAVENIDIGG T++R+
Sbjct: 117 CSLEDAVENIDIGGPTMVRS 136
Score = 52.8 bits (121), Expect = 1e-05
Identities = 25/58 (43%), Positives = 36/58 (62%)
Frame = +3
Query: 252 SKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYF 425
+KNH V +V +DY A++ E+ +N T TR LA+KAF HT+ YD I++YF
Sbjct: 138 AKNHKDVAIVVKSSDYPAIITEL-DNNDGSLTYPTRFNLAIKAFEHTAAYDSMIANYF 194
>UniRef50_A1K9K5 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=2; Bacteria|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Azoarcus sp.
(strain BH72)
Length = 527
Score = 91.9 bits (218), Expect = 2e-17
Identities = 46/81 (56%), Positives = 56/81 (69%), Gaps = 1/81 (1%)
Frame = +2
Query: 11 TRAPEMLGGRVKTLHPAVHAGILARLSDSDQED-MKRQKYEMISVVVCNLYPFVQTVSKP 187
T PEML GRVKTLHP VH GILAR ++ D + I +VV NLYPF TV++P
Sbjct: 54 TGFPEMLDGRVKTLHPKVHGGILARRDLAEHMDTIAAHDISRIDLVVVNLYPFQATVARP 113
Query: 188 DVTVADAVENIDIGGVTLLRA 250
D T+ DA+ENIDIGG T++RA
Sbjct: 114 DCTLEDAIENIDIGGPTMVRA 134
Score = 57.2 bits (132), Expect = 5e-07
Identities = 45/113 (39%), Positives = 56/113 (49%), Gaps = 21/113 (18%)
Frame = +3
Query: 246 AXSKNHDR----VTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAI 413
A +KNH V +V DP DY +V E+K N + + TR LA+KAFTHT+ YD AI
Sbjct: 134 AAAKNHGTEAGGVGIVTDPEDYAGIVAELKANAN-TLSYKTRFALAVKAFTHTARYDSAI 192
Query: 414 SDYF-----------RKQYSPGQAQL------TLRYGMNPHQKPAQVFTPETA 521
S++ KQ P + QL LRYG NPHQ A P A
Sbjct: 193 SNHLTALVTNDAGDVSKQAYPERFQLAFDKVQNLRYGENPHQSAAFYKEPGAA 245
>UniRef50_Q8F3W6 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=6; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Leptospira interrogans
Length = 511
Score = 90.2 bits (214), Expect = 6e-17
Identities = 42/81 (51%), Positives = 61/81 (75%), Gaps = 1/81 (1%)
Frame = +2
Query: 11 TRAPEMLGGRVKTLHPAVHAGILARLSD-SDQEDMKRQKYEMISVVVCNLYPFVQTVSKP 187
T PE+L GRVKTLHP VH G+L +S+ + ++ M+ K I +VV NLYPF++TVSKP
Sbjct: 55 TGFPEILDGRVKTLHPKVHGGLLGVISNPAHKQKMEELKIPKIDLVVVNLYPFLKTVSKP 114
Query: 188 DVTVADAVENIDIGGVTLLRA 250
+V + +A+ENIDIGG +++R+
Sbjct: 115 EVQLEEAIENIDIGGPSMIRS 135
Score = 46.4 bits (105), Expect = 0.001
Identities = 32/88 (36%), Positives = 43/88 (48%), Gaps = 9/88 (10%)
Frame = +3
Query: 252 SKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYFRK 431
+KN+ V+ DP DY + I + + + R KAF+HT+ YD AIS +F K
Sbjct: 137 AKNYKHTLVLTDPNDYKKIQNLISSSGISEEISASYMR---KAFSHTAMYDAAISSWFYK 193
Query: 432 QYS---PGQAQLT------LRYGMNPHQ 488
Q P L+ LRYG NPHQ
Sbjct: 194 QSGEVFPDVLNLSFIKKQKLRYGENPHQ 221
>UniRef50_Q2JI00 Cluster: Bifunctional purine biosynthesis protein
PurH; n=1; Synechococcus sp. JA-2-3B'a(2-13)|Rep:
Bifunctional purine biosynthesis protein PurH -
Synechococcus sp. (strain JA-2-3B'a(2-13))
(Cyanobacteria bacteriumYellowstone B-Prime)
Length = 577
Score = 89.8 bits (213), Expect = 8e-17
Identities = 46/81 (56%), Positives = 57/81 (70%), Gaps = 1/81 (1%)
Frame = +2
Query: 11 TRAPEMLGGRVKTLHPAVHAGILARLSDS-DQEDMKRQKYEMISVVVCNLYPFVQTVSKP 187
T APE+LGGRVKTLHP +H GILARL S D+ D++ I +VV N YPF QTV++
Sbjct: 67 TGAPEILGGRVKTLHPRIHGGILARLECSEDRADLEALGIPPIQLVVVNFYPFEQTVAQA 126
Query: 188 DVTVADAVENIDIGGVTLLRA 250
V++ +A E IDIGG TL RA
Sbjct: 127 GVSLEEAFEQIDIGGPTLARA 147
Score = 35.9 bits (79), Expect = 1.3
Identities = 31/109 (28%), Positives = 43/109 (39%), Gaps = 17/109 (15%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYF 425
A +KN+ VTV+ DP+ Y ++ + L R + A +AF YD AI Y
Sbjct: 147 AAAKNYPYVTVLTDPSQYPRYLQLLSGAYGETERLAFRFQCARRAFEQVLAYDRAIVTYL 206
Query: 426 RKQYSPGQAQLT-----------------LRYGMNPHQKPAQVFTPETA 521
+ G +Q + LRYG NPHQ T A
Sbjct: 207 ARLELAGPSQSSAAAAEDRFQLQGILWQRLRYGENPHQAATWYVTDPAA 255
>UniRef50_Q2JR47 Cluster: Bifunctional purine biosynthesis protein
PurH; n=12; Bacteria|Rep: Bifunctional purine
biosynthesis protein PurH - Synechococcus sp. (strain
JA-3-3Ab) (Cyanobacteria bacteriumYellowstone A-Prime)
Length = 537
Score = 89.0 bits (211), Expect = 1e-16
Identities = 45/81 (55%), Positives = 56/81 (69%), Gaps = 1/81 (1%)
Frame = +2
Query: 11 TRAPEMLGGRVKTLHPAVHAGILARLSD-SDQEDMKRQKYEMISVVVCNLYPFVQTVSKP 187
T APE+LGGRVKTLHP +H GILARL D+ D++ I +VV N YPF QTV++
Sbjct: 59 TGAPEILGGRVKTLHPRIHGGILARLERREDRADLEALGIPPIQLVVVNFYPFEQTVARA 118
Query: 188 DVTVADAVENIDIGGVTLLRA 250
V++ +A E IDIGG TL RA
Sbjct: 119 GVSLEEAFEQIDIGGPTLARA 139
Score = 40.7 bits (91), Expect = 0.047
Identities = 35/100 (35%), Positives = 45/100 (45%), Gaps = 19/100 (19%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYF 425
A +KN+ VTV+ DP+ Y ++ + L R + A +AF YD AI DY
Sbjct: 139 AAAKNYPHVTVLTDPSQYPQYLQLLSSPSSEAERLAFRFQCARRAFEQVLAYDRAIVDYL 198
Query: 426 -RKQYS-PGQA-----------QL------TLRYGMNPHQ 488
R + S P QA QL LRYG NPHQ
Sbjct: 199 TRSELSRPSQAPAPATAAEQVFQLQGIPWQRLRYGENPHQ 238
>UniRef50_Q8PYG4 Cluster: Formyltransferase
phosphoribosylaminoimidazolecarboxamide; n=4;
Methanosarcinaceae|Rep: Formyltransferase
phosphoribosylaminoimidazolecarboxamide - Methanosarcina
mazei (Methanosarcina frisia)
Length = 538
Score = 89.0 bits (211), Expect = 1e-16
Identities = 41/82 (50%), Positives = 57/82 (69%), Gaps = 1/82 (1%)
Frame = +2
Query: 8 ITRAPEMLGGRVKTLHPAVHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSK 184
+T PEM+GGRVKTLHP +H G+L R S E+ ++ +I ++ NLYPF TVS+
Sbjct: 52 VTGYPEMMGGRVKTLHPRIHGGLLCLRESKEQMEEAAKEDISLIDLIAVNLYPFEITVSR 111
Query: 185 PDVTVADAVENIDIGGVTLLRA 250
+V + +A+ENIDIGG TLLR+
Sbjct: 112 ENVELEEAIENIDIGGPTLLRS 133
Score = 57.6 bits (133), Expect = 4e-07
Identities = 34/87 (39%), Positives = 48/87 (55%), Gaps = 7/87 (8%)
Frame = +3
Query: 252 SKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYFRK 431
+KN+ VTV+ DP+DY ++KE++ + TR LA+KAF HT+DYD AI Y +
Sbjct: 135 AKNYRSVTVLSDPSDYGRILKELRSSGIISDK--TRAELAVKAFRHTADYDAAIDTYLSR 192
Query: 432 QYSPGQA-------QLTLRYGMNPHQK 491
+ + LRYG N HQK
Sbjct: 193 TLLGEEVLHLKFADGVKLRYGENWHQK 219
>UniRef50_Q9F1T4 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=57; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Streptococcus suis
Length = 515
Score = 88.2 bits (209), Expect = 2e-16
Identities = 43/82 (52%), Positives = 57/82 (69%), Gaps = 1/82 (1%)
Frame = +2
Query: 8 ITRAPEMLGGRVKTLHPAVHAGILARLS-DSDQEDMKRQKYEMISVVVCNLYPFVQTVSK 184
+T PEM+ GRVKTLHP +H G+LAR DS + + +I +VV NLYPF +T+ +
Sbjct: 52 VTGFPEMMDGRVKTLHPKIHGGLLARRDLDSHLQAANDHEIGLIDLVVVNLYPFKETILR 111
Query: 185 PDVTVADAVENIDIGGVTLLRA 250
PDVT AVENIDIGG ++LR+
Sbjct: 112 PDVTYDLAVENIDIGGPSMLRS 133
Score = 74.5 bits (175), Expect = 3e-12
Identities = 39/77 (50%), Positives = 49/77 (63%), Gaps = 1/77 (1%)
Frame = +3
Query: 252 SKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYFRK 431
+KNH VTVV DPADY V+ EI E +T+ TRQRLA K F HT+ YD I+DYF K
Sbjct: 135 AKNHASVTVVVDPADYPTVLGEIAEQG--ETSYATRQRLAAKVFRHTAAYDALIADYFTK 192
Query: 432 QYSPGQAQ-LTLRYGMN 479
Q + + LT+ Y +N
Sbjct: 193 QVGEDKPEKLTITYDLN 209
>UniRef50_Q8CXK7 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=34; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Oceanobacillus iheyensis
Length = 510
Score = 88.2 bits (209), Expect = 2e-16
Identities = 41/82 (50%), Positives = 55/82 (67%), Gaps = 1/82 (1%)
Frame = +2
Query: 8 ITRAPEMLGGRVKTLHPAVHAGILARLSDSDQ-EDMKRQKYEMISVVVCNLYPFVQTVSK 184
+T PEML GRVKTLHP +H G+L + S+ + M+ I +V NLYPF +TV K
Sbjct: 52 VTGFPEMLDGRVKTLHPMIHGGLLGKRSNHEHLSQMEEHGIRSIDLVAVNLYPFKETVQK 111
Query: 185 PDVTVADAVENIDIGGVTLLRA 250
PDV+ D +ENIDIGG ++LR+
Sbjct: 112 PDVSHQDIIENIDIGGPSMLRS 133
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/91 (39%), Positives = 46/91 (50%), Gaps = 9/91 (9%)
Frame = +3
Query: 252 SKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYFRK 431
+KN + V VV P DY+ V+ I T RQ+LA K F HT+ YD I++YF
Sbjct: 135 AKNFEDVLVVTGPTDYNRVLAAITSETD---TYEFRQQLAAKVFRHTASYDAMIANYFLS 191
Query: 432 QYS---PGQAQLT------LRYGMNPHQKPA 497
Q P +T LRYG NPHQ+ A
Sbjct: 192 QTEEQYPESYTVTYEKVQDLRYGENPHQQAA 222
>UniRef50_P12048 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=71; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Bacillus subtilis
Length = 512
Score = 85.0 bits (201), Expect = 2e-15
Identities = 40/82 (48%), Positives = 56/82 (68%), Gaps = 1/82 (1%)
Frame = +2
Query: 8 ITRAPEMLGGRVKTLHPAVHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSK 184
+T PE++ GR+KTLHP +H G+LA R ++ + + I +VV NLYPF +T+SK
Sbjct: 53 VTGFPEIMDGRLKTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVNLYPFKETISK 112
Query: 185 PDVTVADAVENIDIGGVTLLRA 250
DVT +A+ENIDIGG +LRA
Sbjct: 113 EDVTYEEAIENIDIGGPGMLRA 134
Score = 68.5 bits (160), Expect = 2e-10
Identities = 40/91 (43%), Positives = 51/91 (56%), Gaps = 9/91 (9%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYF 425
A SKNH VTV+ DPADY V+ +IKE +L ++ LA K F HT+ YD I+DY
Sbjct: 134 AASKNHQDVTVIVDPADYSPVLNQIKE--EGSVSLQKKRELAAKVFRHTAAYDALIADYL 191
Query: 426 RK---QYSPGQAQLT------LRYGMNPHQK 491
+ P Q +T LRYG NPHQ+
Sbjct: 192 TNVVGEKEPEQFTVTFEKKQSLRYGENPHQE 222
>UniRef50_Q83EI4 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=5; Coxiella
burnetii|Rep: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Coxiella burnetii
Length = 526
Score = 83.8 bits (198), Expect = 5e-15
Identities = 41/80 (51%), Positives = 57/80 (71%)
Frame = +2
Query: 11 TRAPEMLGGRVKTLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPD 190
T PE++ GRVKTLHP +HAG+LAR D++ + + + I ++V NLYPFVQTVS +
Sbjct: 62 TGFPEIMDGRVKTLHPKIHAGLLARRG-IDEKTLDQHAIKPIDLLVVNLYPFVQTVSASN 120
Query: 191 VTVADAVENIDIGGVTLLRA 250
++ AVE IDIGG ++LRA
Sbjct: 121 CSLEKAVEQIDIGGPSMLRA 140
Score = 67.7 bits (158), Expect = 4e-10
Identities = 41/94 (43%), Positives = 53/94 (56%), Gaps = 10/94 (10%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYF 425
A +KN VTVV DP DY +++EIK + H TTL TR+RLA K F H S YD I+ Y
Sbjct: 140 AAAKNFAAVTVVVDPEDYSRILEEIKTH-HGSTTLSTRKRLAQKTFEHLSYYDAHIATYL 198
Query: 426 RKQY----------SPGQAQLTLRYGMNPHQKPA 497
++ S + ++ LRYG NPHQ A
Sbjct: 199 AEKEGATTLPARLPSIFKKKIDLRYGENPHQTAA 232
>UniRef50_Q6L122 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=4; Thermoplasmatales|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Picrophilus torridus
Length = 494
Score = 83.4 bits (197), Expect = 7e-15
Identities = 39/81 (48%), Positives = 55/81 (67%)
Frame = +2
Query: 8 ITRAPEMLGGRVKTLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKP 187
IT ++L GRVKTLHPAV +GIL+R + + D+KR Y +V+CNLY F + K
Sbjct: 47 ITGFDDLLNGRVKTLHPAVFSGILSRRDEQSEADLKRYNYFDFDIVICNLYNFESYIDK- 105
Query: 188 DVTVADAVENIDIGGVTLLRA 250
++ D +ENIDIGG++L+RA
Sbjct: 106 --SIEDMIENIDIGGLSLIRA 124
Score = 51.6 bits (118), Expect = 3e-05
Identities = 30/90 (33%), Positives = 49/90 (54%), Gaps = 9/90 (10%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAI---- 413
A +KN+ VTV P DY+ ++K++++ + +L TR+ LAL+AF + YD+ I
Sbjct: 124 AAAKNYQHVTVASSPEDYNIIIKDLRDG---EISLRTRETLALRAFARAAYYDMIIYKSL 180
Query: 414 -----SDYFRKQYSPGQAQLTLRYGMNPHQ 488
+D + + G + LRYG NP Q
Sbjct: 181 YKRLNNDEPEELFIHGYDRTKLRYGENPDQ 210
>UniRef50_Q9PC10 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=214; cellular organisms|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Xylella fastidiosa
Length = 527
Score = 83.4 bits (197), Expect = 7e-15
Identities = 41/83 (49%), Positives = 54/83 (65%)
Frame = +2
Query: 2 AXITRAPEMLGGRVKTLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVS 181
A +T PEM+ GRVKTLHP VH G+L R + D M + I +++ NLYPF Q +
Sbjct: 56 ADLTGFPEMMDGRVKTLHPMVHGGLLGR-AGIDDAVMAKHGIAPIDLLILNLYPFEQITA 114
Query: 182 KPDVTVADAVENIDIGGVTLLRA 250
K D T+ADAV+ IDIGG +LR+
Sbjct: 115 KKDCTLADAVDTIDIGGPAMLRS 137
Score = 44.4 bits (100), Expect = 0.004
Identities = 34/99 (34%), Positives = 45/99 (45%), Gaps = 17/99 (17%)
Frame = +3
Query: 252 SKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYFR- 428
+KN RV V P Y ++ E++ + H Q + R LA+ AF H + YD AIS+Y
Sbjct: 139 AKNFARVAVATSPDQYPDLLAELQAH-HGQLSAEKRFALAVAAFNHVAQYDAAISNYLSS 197
Query: 429 ----------KQYSPGQAQLT------LRYGMNPHQKPA 497
+ P Q T LRYG NPHQ A
Sbjct: 198 VSDMHTTLPLRHEFPAQLNNTFVKMTELRYGENPHQTGA 236
>UniRef50_Q1V178 Cluster: Bifunctional purine biosynthesis protein;
n=2; Candidatus Pelagibacter ubique|Rep: Bifunctional
purine biosynthesis protein - Candidatus Pelagibacter
ubique HTCC1002
Length = 518
Score = 83.0 bits (196), Expect = 9e-15
Identities = 38/81 (46%), Positives = 59/81 (72%), Gaps = 1/81 (1%)
Frame = +2
Query: 11 TRAPEMLGGRVKTLHPAVHAGILARLSD-SDQEDMKRQKYEMISVVVCNLYPFVQTVSKP 187
T +PE+LGGRVKTLHP +HAGIL++ +D S +++K +Y+ I +V+ N YPF +T+ +
Sbjct: 62 TGSPEILGGRVKTLHPKIHAGILSKRNDKSHTKELKANQYDEIDLVIVNFYPFEKTLDQ- 120
Query: 188 DVTVADAVENIDIGGVTLLRA 250
+ +ENID+GG T++RA
Sbjct: 121 TTNHSKIIENIDVGGPTMVRA 141
Score = 60.1 bits (139), Expect = 7e-08
Identities = 33/93 (35%), Positives = 55/93 (59%), Gaps = 9/93 (9%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYF 425
A +KN++ VTV+ Y+ ++ E++ NK T++ R++++L+AF+ T+ YD IS+YF
Sbjct: 141 AAAKNYNDVTVITSSDQYETLINELENNKG-STSIEFREKMSLEAFSETAYYDAVISNYF 199
Query: 426 ---------RKQYSPGQAQLTLRYGMNPHQKPA 497
+K+ G LRYG NPHQ+ A
Sbjct: 200 NKIKKNNFPKKKIIYGNLIEKLRYGENPHQEAA 232
>UniRef50_Q9FPL3 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=14;
Viridiplantae|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Nicotiana tabacum
(Common tobacco)
Length = 612
Score = 82.6 bits (195), Expect = 1e-14
Identities = 42/83 (50%), Positives = 54/83 (65%), Gaps = 2/83 (2%)
Frame = +2
Query: 8 ITRAPEMLGGRVKTLHPAVHAGILARL-SDSDQEDMKRQKYEMISVVVCNLYPFVQTVSK 184
+TR PEML GRVKTLHP+VH GILAR + E +++ + VVV NLYPF VS
Sbjct: 138 LTRFPEMLDGRVKTLHPSVHGGILARRDQEHHMEALEKHEIGTFDVVVVNLYPFYAKVSS 197
Query: 185 PD-VTVADAVENIDIGGVTLLRA 250
++ D +ENIDIGG ++RA
Sbjct: 198 SSGISFEDGIENIDIGGPAMIRA 220
Score = 58.4 bits (135), Expect = 2e-07
Identities = 37/94 (39%), Positives = 52/94 (55%), Gaps = 10/94 (10%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYF 425
A +KNH V VV D DY A+++ ++ + Q R++LA KAF H + YD A+S++
Sbjct: 220 AAAKNHRDVLVVVDSEDYPALLEFLRGDNDDQQF---RRKLAWKAFQHVASYDSAVSEWL 276
Query: 426 RKQ-----YSPG-----QAQLTLRYGMNPHQKPA 497
KQ + PG + LRYG NPHQK A
Sbjct: 277 WKQTVGDKFPPGLTVPLHLKSLLRYGENPHQKAA 310
>UniRef50_Q7X311 Cluster: Putative AICAR transformylase; n=1;
uncultured Acidobacteria bacterium|Rep: Putative AICAR
transformylase - uncultured Acidobacteria bacterium
Length = 571
Score = 80.6 bits (190), Expect = 5e-14
Identities = 38/82 (46%), Positives = 55/82 (67%), Gaps = 1/82 (1%)
Frame = +2
Query: 8 ITRAPEMLGGRVKTLHPAVHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSK 184
+T PEM+ GRVKTLHP +H G+L R S S + M+ E I +VV +LYPF +T+
Sbjct: 62 VTGFPEMMDGRVKTLHPKIHGGLLGVRDSPSHESSMREHGIEPIDMVVIDLYPFERTIKG 121
Query: 185 PDVTVADAVENIDIGGVTLLRA 250
V++A+A+E IDIGG ++R+
Sbjct: 122 AAVSLAEAIEQIDIGGPAMIRS 143
Score = 35.1 bits (77), Expect = 2.3
Identities = 18/57 (31%), Positives = 32/57 (56%)
Frame = +3
Query: 252 SKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDY 422
+KN V V+ + ++Y + +E++ + +L TR+RLA AF T+ YD + Y
Sbjct: 145 AKNFHSVAVITNTSEYGPIAEELRAHDC-SLSLHTRRRLAEIAFQRTAQYDSIVFGY 200
>UniRef50_A5E8X1 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase /IMP cyclohydrolase; n=4;
Bacteria|Rep: Phosphoribosylaminoimidazolecarboxamide
formyltransferase /IMP cyclohydrolase - Bradyrhizobium
sp. (strain BTAi1 / ATCC BAA-1182)
Length = 530
Score = 78.6 bits (185), Expect = 2e-13
Identities = 41/82 (50%), Positives = 52/82 (63%), Gaps = 1/82 (1%)
Frame = +2
Query: 8 ITRAPEMLGGRVKTLHPAVHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSK 184
+T PEM+ GRVKTLHP VH G+LA R +D E MK I ++V NLYPF TV +
Sbjct: 58 LTGFPEMMDGRVKTLHPKVHGGLLAIRGNDEHAEAMKTHGIAPIDLLVVNLYPFEATVER 117
Query: 185 PDVTVADAVENIDIGGVTLLRA 250
+D +ENIDIGG ++RA
Sbjct: 118 -SAPFSDCIENIDIGGPAMIRA 138
Score = 66.5 bits (155), Expect = 8e-10
Identities = 41/93 (44%), Positives = 57/93 (61%), Gaps = 9/93 (9%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYF 425
A SKNH+ V VV D DYDAV++++ ++ TTL R+RLA KA+ T+ YD AIS++F
Sbjct: 138 AASKNHEDVAVVVDVNDYDAVLEDLARHE-GSTTLLLRRRLAAKAYARTAAYDAAISNWF 196
Query: 426 R---KQYSP------GQAQLTLRYGMNPHQKPA 497
+ +P G+ +LRYG NPHQ A
Sbjct: 197 AATIQNDAPDYRAFGGRLIQSLRYGENPHQHAA 229
>UniRef50_A0JTW4 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=2;
Arthrobacter|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Arthrobacter sp.
(strain FB24)
Length = 559
Score = 78.6 bits (185), Expect = 2e-13
Identities = 42/82 (51%), Positives = 52/82 (63%), Gaps = 1/82 (1%)
Frame = +2
Query: 8 ITRAPEMLGGRVKTLHPAVHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSK 184
+T +PEML GRVKTLHP VH GILA R + E + + E +VV NLYPFV+TV K
Sbjct: 61 VTGSPEMLDGRVKTLHPRVHGGILADRRVPAHMETLAGMEIEAFDLVVVNLYPFVETV-K 119
Query: 185 PDVTVADAVENIDIGGVTLLRA 250
D VE IDIGG ++R+
Sbjct: 120 SGAAQDDVVEQIDIGGPAMVRS 141
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/98 (39%), Positives = 48/98 (48%), Gaps = 16/98 (16%)
Frame = +3
Query: 252 SKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYFRK 431
+KNH V +V DP Y VV+ E L TRQRLA KAF HT+ YD A++ +
Sbjct: 143 AKNHAAVAIVTDPNFYGDVVRAAAEGGFD---LKTRQRLAAKAFAHTASYDTAVATWTAS 199
Query: 432 QYS----------PGQAQL------TLRYGMNPHQKPA 497
Q+ P A L LRYG NPHQ+ A
Sbjct: 200 QFLDEDGDGVIDWPAYAGLALERSEVLRYGENPHQQAA 237
>UniRef50_Q8XMK2 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=14; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Clostridium perfringens
Length = 501
Score = 78.6 bits (185), Expect = 2e-13
Identities = 43/82 (52%), Positives = 55/82 (67%), Gaps = 1/82 (1%)
Frame = +2
Query: 8 ITRAPEMLGGRVKTLHPAVHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSK 184
IT PEML GRVKTLHP VHAGILA R + + ++ ++ I VV NLYPF + V +
Sbjct: 52 ITDFPEMLDGRVKTLHPLVHAGILAIRDNKEHMKTLEEREINTIDYVVVNLYPFFEKV-R 110
Query: 185 PDVTVADAVENIDIGGVTLLRA 250
D++ + VE IDIGG T+LRA
Sbjct: 111 EDLSFEEKVEFIDIGGPTMLRA 132
Score = 49.6 bits (113), Expect = 1e-04
Identities = 37/98 (37%), Positives = 51/98 (52%), Gaps = 8/98 (8%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYF 425
A +KN V V+ D DY+ V+ EIKEN + + R+ LA K F S YD AIS++
Sbjct: 132 AAAKNFKDVVVLSDKKDYEKVMNEIKEN--NCVSFKLRKTLAGKVFNLMSAYDAAISNFL 189
Query: 426 ---RKQY----SPGQAQL-TLRYGMNPHQKPAQVFTPE 515
++Y S ++ LRYG NPHQ A + E
Sbjct: 190 LEGEEEYPEYLSVSYKKIQDLRYGENPHQGAAYYSSTE 227
>UniRef50_O67775 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=9; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Aquifex aeolicus
Length = 506
Score = 78.6 bits (185), Expect = 2e-13
Identities = 43/82 (52%), Positives = 56/82 (68%), Gaps = 1/82 (1%)
Frame = +2
Query: 8 ITRAPEMLGGRVKTLHPAVHAGILAR-LSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSK 184
IT PE+L GRVKTLHP VH GIL R + D+E++++ + I VVV NLYPF + + K
Sbjct: 50 ITGFPEILEGRVKTLHPVVHGGILFRDWVEKDKEEIEKHGIKPIDVVVVNLYPFEEKL-K 108
Query: 185 PDVTVADAVENIDIGGVTLLRA 250
+T D +E IDIGG TL+RA
Sbjct: 109 EGLTDKDLMEFIDIGGPTLIRA 130
Score = 64.1 bits (149), Expect = 4e-09
Identities = 39/92 (42%), Positives = 52/92 (56%), Gaps = 10/92 (10%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYF 425
A +KN RV ++ DP DYD V++++K+ TL R LA KAF+HT+ YD IS F
Sbjct: 130 AAAKNFFRVVILVDPEDYDWVIEKLKKGN---LTLQDRAYLAWKAFSHTAYYDGVISQAF 186
Query: 426 RKQYS----------PGQAQLTLRYGMNPHQK 491
+K YS P + LRYG NPHQ+
Sbjct: 187 KKLYSIDTFGKEEALPLKRMQKLRYGENPHQR 218
>UniRef50_A7HM64 Cluster: IMP cyclohydrolase; n=1; Fervidobacterium
nodosum Rt17-B1|Rep: IMP cyclohydrolase -
Fervidobacterium nodosum Rt17-B1
Length = 429
Score = 77.4 bits (182), Expect = 4e-13
Identities = 44/82 (53%), Positives = 52/82 (63%), Gaps = 1/82 (1%)
Frame = +2
Query: 8 ITRAPEMLGGRVKTLHPAVHAGILARLSD-SDQEDMKRQKYEMISVVVCNLYPFVQTVSK 184
+T PE+LGGRVKTLHP + GILA L D S +D++ E I +VV NLYPF V K
Sbjct: 53 VTGFPEILGGRVKTLHPKIFGGILADLGDKSHVKDLRDNFIEPIDLVVVNLYPF-DEVQK 111
Query: 185 PDVTVADAVENIDIGGVTLLRA 250
+ENIDIGGV LLRA
Sbjct: 112 KTRDEDVLIENIDIGGVALLRA 133
Score = 55.6 bits (128), Expect = 2e-06
Identities = 32/80 (40%), Positives = 43/80 (53%), Gaps = 1/80 (1%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYF 425
A +KNH V VVCDPADYD V+K I + L R+ ALKAF HT YD I
Sbjct: 133 AAAKNHRNVVVVCDPADYDKVIKSI--DLCGDVQLHDRRMFALKAFYHTMKYDATIHRVL 190
Query: 426 RKQYSPGQAQ-LTLRYGMNP 482
+ ++ + + +T +NP
Sbjct: 191 SELFASEKFEHMTFERFINP 210
>UniRef50_Q8A155 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=5; Bacteroides|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Bacteroides thetaiotaomicron
Length = 507
Score = 77.0 bits (181), Expect = 6e-13
Identities = 40/83 (48%), Positives = 57/83 (68%), Gaps = 2/83 (2%)
Frame = +2
Query: 8 ITRAPEMLGGRVKTLHPAVHAGILARLSDSDQEDMKRQKYEM--ISVVVCNLYPFVQTVS 181
+T P +LGGRVKTLHP + GIL R D +Q+ + +KYE+ I +V+ +LYPF TV+
Sbjct: 57 LTTYPSILGGRVKTLHPKIFGGILCR-RDLEQDIQQIEKYEIPEIDLVIVDLYPFEATVA 115
Query: 182 KPDVTVADAVENIDIGGVTLLRA 250
+ AD +E IDIGG++L+RA
Sbjct: 116 S-GASEADIIEKIDIGGISLIRA 137
Score = 44.8 bits (101), Expect = 0.003
Identities = 30/87 (34%), Positives = 45/87 (51%), Gaps = 5/87 (5%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYF 425
A +KN++ V +V A Y ++ + E+ ++L R+ +A +AF +S YD AI +YF
Sbjct: 137 AAAKNYNDVIIVASQAQYKPLLDMLMEHGA-TSSLEERRWMAKEAFAVSSHYDSAIFNYF 195
Query: 426 RKQYSPG-----QAQLTLRYGMNPHQK 491
Q LRYG NPHQK
Sbjct: 196 DAGEGSAFRCSVNNQKQLRYGENPHQK 222
>UniRef50_Q9RW01 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=3; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Deinococcus radiodurans
Length = 510
Score = 76.2 bits (179), Expect = 1e-12
Identities = 40/83 (48%), Positives = 52/83 (62%), Gaps = 2/83 (2%)
Frame = +2
Query: 8 ITRAPEMLGGRVKTLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSK- 184
+T PEML GRVKTLHPA+H GILAR + Q I +V NLYPF +TV++
Sbjct: 52 VTGFPEMLDGRVKTLHPAIHGGILARREAGHLGQLAAQDIGTIDLVCVNLYPFRETVARG 111
Query: 185 -PDVTVADAVENIDIGGVTLLRA 250
PD + +ENIDIGG ++R+
Sbjct: 112 APD---PEVIENIDIGGPAMIRS 131
Score = 53.6 bits (123), Expect = 6e-06
Identities = 35/94 (37%), Positives = 48/94 (51%), Gaps = 12/94 (12%)
Frame = +3
Query: 252 SKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYFRK 431
+KNHD V V+ DPADY +++ + + R+RLA KA+ HTS+YD AI+ Y
Sbjct: 133 AKNHDAVLVLVDPADYALALQD-------EVSPAERRRLAAKAYRHTSEYDAAITAYLSG 185
Query: 432 QYSPGQAQL------------TLRYGMNPHQKPA 497
+ QL +RYG NPHQ A
Sbjct: 186 ESDELPTQLPEHLSLDLTRTAQVRYGENPHQPGA 219
>UniRef50_Q7MUT5 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=24;
Bacteria|Rep: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Porphyromonas
gingivalis (Bacteroides gingivalis)
Length = 508
Score = 75.8 bits (178), Expect = 1e-12
Identities = 38/81 (46%), Positives = 53/81 (65%), Gaps = 1/81 (1%)
Frame = +2
Query: 8 ITRAPEMLGGRVKTLHPAVHAGILARLS-DSDQEDMKRQKYEMISVVVCNLYPFVQTVSK 184
+TR P MLGGRVKTLHP + GILAR +SD ++ +I +V+ +LYPF TV+
Sbjct: 58 LTRYPSMLGGRVKTLHPMIFGGILARRGHESDVREVGEYGLPLIDLVIVDLYPFEATVAS 117
Query: 185 PDVTVADAVENIDIGGVTLLR 247
+ D +E IDIGG++L+R
Sbjct: 118 -GASEEDIIEKIDIGGISLIR 137
Score = 42.7 bits (96), Expect = 0.012
Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 5/85 (5%)
Frame = +3
Query: 252 SKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYFR- 428
+KN + V ++ A Y +KE + +T+L R+ A +AF +S YD AI YF
Sbjct: 140 AKNFEDVVIISSRAQYAGFYSLLKE-QGARTSLAERRHYAREAFAVSSAYDSAIFRYFDD 198
Query: 429 -KQYS---PGQAQLTLRYGMNPHQK 491
+Q + + LRYG NPHQ+
Sbjct: 199 GEQTAFRMSADSPKVLRYGENPHQR 223
>UniRef50_A7DF55 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=3;
Alphaproteobacteria|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Methylobacterium
extorquens PA1
Length = 581
Score = 75.8 bits (178), Expect = 1e-12
Identities = 40/82 (48%), Positives = 52/82 (63%), Gaps = 1/82 (1%)
Frame = +2
Query: 8 ITRAPEMLGGRVKTLHPAVHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSK 184
+TR PEM+ GRVKTLHPAVH G+LA R + Q + I ++V NLYPF +T+ K
Sbjct: 107 LTRFPEMMDGRVKTLHPAVHGGLLAVRDNPEHQAALAAHGIGAIDLLVVNLYPFEETL-K 165
Query: 185 PDVTVADAVENIDIGGVTLLRA 250
D VENID+GG ++RA
Sbjct: 166 AGKAYDDCVENIDVGGPAMIRA 187
Score = 62.5 bits (145), Expect = 1e-08
Identities = 40/101 (39%), Positives = 56/101 (55%), Gaps = 10/101 (9%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYF 425
A +KNH V VV D +DY A++ E+ E+ + T TR+RLA KAF+ T+ YD AI+++
Sbjct: 187 AAAKNHADVAVVVDVSDYGAILAELAEHDGNLTAT-TRRRLAQKAFSRTASYDAAIANWL 245
Query: 426 R----KQYSP------GQAQLTLRYGMNPHQKPAQVFTPET 518
+ +P G +LRYG NPHQ A P T
Sbjct: 246 AEVEGRDKAPTFKALGGTLAQSLRYGENPHQSAAFYRLPGT 286
>UniRef50_UPI00015BCE7E Cluster: UPI00015BCE7E related cluster; n=1;
unknown|Rep: UPI00015BCE7E UniRef100 entry - unknown
Length = 506
Score = 75.4 bits (177), Expect = 2e-12
Identities = 42/82 (51%), Positives = 53/82 (64%), Gaps = 1/82 (1%)
Frame = +2
Query: 8 ITRAPEMLGGRVKTLHPAVHAGILARLS-DSDQEDMKRQKYEMISVVVCNLYPFVQTVSK 184
+T E+LGGRVKTLHPA+H GIL R + D E++K E I +VV NLYPF + + K
Sbjct: 50 VTGFREILGGRVKTLHPAIHGGILFREDVEKDLEEIKENSIEPIDIVVVNLYPFEKKM-K 108
Query: 185 PDVTVADAVENIDIGGVTLLRA 250
+ VE IDIGG TL+RA
Sbjct: 109 ELKDIDALVEFIDIGGPTLVRA 130
Score = 54.0 bits (124), Expect = 5e-06
Identities = 37/93 (39%), Positives = 49/93 (52%), Gaps = 11/93 (11%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYF 425
A +KNH RV+V+ D DY ++++K N Q R+ LALKAF TS YD I+ YF
Sbjct: 130 AAAKNHKRVSVLTDIEDYGWFIEKLKMNAVSQQD---RKYLALKAFWLTSYYDAVIASYF 186
Query: 426 RKQYS-----------PGQAQLTLRYGMNPHQK 491
K + P + LRYG NPHQ+
Sbjct: 187 SKVFGFSEKDFKHHTVPMFLRDELRYGENPHQQ 219
>UniRef50_A1IEQ8 Cluster: IMP cyclohydrolase; n=1; Candidatus
Desulfococcus oleovorans Hxd3|Rep: IMP cyclohydrolase -
Candidatus Desulfococcus oleovorans Hxd3
Length = 225
Score = 72.9 bits (171), Expect = 1e-11
Identities = 40/81 (49%), Positives = 50/81 (61%), Gaps = 1/81 (1%)
Frame = +2
Query: 11 TRAPEMLGGRVKTLHPAVHAGILARL-SDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKP 187
T PE GG VKTL ++ G+L ++S DMKR I +VV NLYPF QTV++P
Sbjct: 73 TGQPETQGGLVKTLDFKIYLGLLTETYNESHARDMKRTGAVAIDMVVVNLYPFSQTVARP 132
Query: 188 DVTVADAVENIDIGGVTLLRA 250
DVT A NIDIGG ++RA
Sbjct: 133 DVTPEQARGNIDIGGPCMVRA 153
Score = 60.9 bits (141), Expect = 4e-08
Identities = 32/63 (50%), Positives = 41/63 (65%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYF 425
A +KN RV V DPADY+ V E+ E++ +L TR LA KAF HT+ YD AI+DY
Sbjct: 153 ASAKNFLRVASVVDPADYNTVADEM-EHRQGALSLDTRFELAQKAFDHTAAYDRAIADYL 211
Query: 426 RKQ 434
+KQ
Sbjct: 212 KKQ 214
>UniRef50_A2SS05 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=3;
Methanomicrobiales|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase -
Methanocorpusculum labreanum (strain ATCC 43576 / DSM
4855 / Z)
Length = 497
Score = 72.9 bits (171), Expect = 1e-11
Identities = 37/80 (46%), Positives = 52/80 (65%)
Frame = +2
Query: 11 TRAPEMLGGRVKTLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPD 190
T+ PEM+ GRVKTLHP VH G+L R D + MK E I ++ NLYPF + +SK +
Sbjct: 52 TQFPEMMDGRVKTLHPKVHGGLLGR-RGIDDDVMKAHFIEPIDILCVNLYPF-EEMSKKN 109
Query: 191 VTVADAVENIDIGGVTLLRA 250
+ + + +E IDIGG ++RA
Sbjct: 110 LPLEELIEFIDIGGPAMIRA 129
Score = 57.2 bits (132), Expect = 5e-07
Identities = 38/92 (41%), Positives = 48/92 (52%), Gaps = 8/92 (8%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYF 425
A SKN+ V V+ DP+DY ++ IK T + RLA KAFT T+ YD AIS+Y
Sbjct: 129 AASKNYKDVAVLTDPSDYPMAIEAIKTGGF---TSEQKLRLATKAFTRTAAYDAAISNYL 185
Query: 426 R---KQYSPGQAQ-----LTLRYGMNPHQKPA 497
K++ LRYG NPHQK A
Sbjct: 186 NGIDKEFPDVYTMQFGNGRKLRYGENPHQKAA 217
>UniRef50_Q8D244 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=2; Gammaproteobacteria|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Wigglesworthia glossinidia
brevipalpis
Length = 529
Score = 72.9 bits (171), Expect = 1e-11
Identities = 32/77 (41%), Positives = 51/77 (66%)
Frame = +2
Query: 20 PEMLGGRVKTLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTV 199
PE++ GRVKTLHP +H GIL+ ++ + + K + I +V+ N YPF + V K ++ +
Sbjct: 62 PEIINGRVKTLHPKIHGGILS--NNKNINENKNLNIKKIDMVITNFYPFKKKVKKENIKI 119
Query: 200 ADAVENIDIGGVTLLRA 250
+ ++NIDIGGV L R+
Sbjct: 120 ENIIDNIDIGGVALARS 136
Score = 33.9 bits (74), Expect = 5.4
Identities = 20/62 (32%), Positives = 31/62 (50%)
Frame = +3
Query: 252 SKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYFRK 431
+KN+ VTVV + Y + E+ +N + TR + AF ++ YD I +YF K
Sbjct: 138 AKNYKYVTVVVNINQYSKLSSEMDKNSG-SVSFKTRFYFSTLAFQYSYSYDKEIFNYFNK 196
Query: 432 QY 437
Y
Sbjct: 197 IY 198
>UniRef50_A7BET6 Cluster: Putative uncharacterized protein; n=1;
Actinomyces odontolyticus ATCC 17982|Rep: Putative
uncharacterized protein - Actinomyces odontolyticus ATCC
17982
Length = 614
Score = 72.5 bits (170), Expect = 1e-11
Identities = 37/82 (45%), Positives = 54/82 (65%), Gaps = 1/82 (1%)
Frame = +2
Query: 8 ITRAPEMLGGRVKTLHPAVHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSK 184
+T PE+L GRVKTLHP +H+GILA + + +E + + + +VVCNLYPF TV+
Sbjct: 66 VTGFPEVLEGRVKTLHPFIHSGILADQRKAAHREQIAQLGIQAFDLVVCNLYPFQDTVAS 125
Query: 185 PDVTVADAVENIDIGGVTLLRA 250
+ + VE IDIGG +++RA
Sbjct: 126 -GASFDECVEQIDIGGPSMVRA 146
Score = 41.9 bits (94), Expect = 0.020
Identities = 27/80 (33%), Positives = 37/80 (46%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYF 425
A +KNH V VV P Y V + + TL R+ LA +AF HT+ YDLAI+ +
Sbjct: 146 AAAKNHPSVAVVTSPERYADVAEAVAGEGF---TLEQRRVLAAEAFAHTATYDLAIAGWL 202
Query: 426 RKQYSPGQAQLTLRYGMNPH 485
+ + TL H
Sbjct: 203 ADELDLEDVRETLDDAAETH 222
>UniRef50_Q8G6B1 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=89; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Bifidobacterium longum
Length = 545
Score = 71.3 bits (167), Expect = 3e-11
Identities = 36/81 (44%), Positives = 52/81 (64%), Gaps = 1/81 (1%)
Frame = +2
Query: 8 ITRAPEMLGGRVKTLHPAVHAGILARLSDSDQ-EDMKRQKYEMISVVVCNLYPFVQTVSK 184
+T PE L GRVKTLHP +HAGILA +++ + + ++ + +VV NLYPF TV +
Sbjct: 58 VTGFPECLDGRVKTLHPYIHAGILADMTNPEHAKQLEEFGIKPFDLVVVNLYPFADTV-R 116
Query: 185 PDVTVADAVENIDIGGVTLLR 247
AD +E IDIGG +++R
Sbjct: 117 SGANEADTIEKIDIGGPSMVR 137
Score = 48.8 bits (111), Expect(2) = 7e-06
Identities = 27/69 (39%), Positives = 38/69 (55%)
Frame = +3
Query: 252 SKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYFRK 431
+KNH V +V DPADY V + + +L R+ LA KAF HT+ YD I+++ K
Sbjct: 140 AKNHATVAIVTDPADYALVASRVADGTGF--SLDERKWLAAKAFAHTAAYDATINEWTAK 197
Query: 432 QYSPGQAQL 458
+ P A L
Sbjct: 198 HW-PKPASL 205
Score = 24.2 bits (50), Expect(2) = 7e-06
Identities = 10/18 (55%), Positives = 11/18 (61%)
Frame = +3
Query: 459 TLRYGMNPHQKPAQVFTP 512
TLRYG N HQ+ A P
Sbjct: 237 TLRYGENSHQQAALYIDP 254
>UniRef50_Q9PNY2 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=21; Epsilonproteobacteria|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Campylobacter jejuni
Length = 510
Score = 69.3 bits (162), Expect = 1e-10
Identities = 35/81 (43%), Positives = 50/81 (61%), Gaps = 1/81 (1%)
Frame = +2
Query: 11 TRAPEMLGGRVKTLHPAVHAGILARLSDSDQ-EDMKRQKYEMISVVVCNLYPFVQTVSKP 187
T++PE+ GRVKTLHP +H GIL + SD + + K + I +V NLYPF +T
Sbjct: 51 TKSPELFEGRVKTLHPKIHGGILHKRSDENHIKQAKENEILGIDLVCVNLYPFKKTTIMS 110
Query: 188 DVTVADAVENIDIGGVTLLRA 250
D + +ENIDIGG ++R+
Sbjct: 111 D-DFDEIIENIDIGGPAMIRS 130
Score = 60.9 bits (141), Expect = 4e-08
Identities = 31/91 (34%), Positives = 53/91 (58%), Gaps = 9/91 (9%)
Frame = +3
Query: 252 SKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYFRK 431
+KN+ V V+CDP DY+ V++ +K+ ++ + R L +KA+ HT++YD I++Y +
Sbjct: 132 AKNYKDVMVLCDPLDYEKVIETLKKGQNDE---NFRLNLMIKAYEHTANYDAYIANYMNE 188
Query: 432 QYS---------PGQAQLTLRYGMNPHQKPA 497
+++ GQ +YG NPHQK A
Sbjct: 189 RFNGGFGASKFIVGQKVFDTKYGENPHQKGA 219
>UniRef50_Q83GZ1 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=2; Tropheryma whipplei|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Tropheryma whipplei (strain Twist)
(Whipple's bacillus)
Length = 542
Score = 68.5 bits (160), Expect = 2e-10
Identities = 34/82 (41%), Positives = 48/82 (58%), Gaps = 1/82 (1%)
Frame = +2
Query: 8 ITRAPEMLGGRVKTLHPAVHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSK 184
+T E+L GRVKTLHP +HA ILA S + +++ + +VV NLYPF +
Sbjct: 57 VTGVGELLDGRVKTLHPKIHAPILADTTSQMHRAQLQQLGVDAFDLVVVNLYPFFEISKN 116
Query: 185 PDVTVADAVENIDIGGVTLLRA 250
+ +D +E IDIGG L+RA
Sbjct: 117 SEAEFSDVIEQIDIGGSALIRA 138
Score = 53.6 bits (123), Expect = 6e-06
Identities = 25/64 (39%), Positives = 41/64 (64%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYF 425
A +KNH RV V+ DP+DY V+ ++ + R +LA+KA++HTS+YDL IS +
Sbjct: 138 AAAKNHTRVVVIVDPSDYIHVINSLERGAPSRL----RHQLAIKAYSHTSEYDLHISRWL 193
Query: 426 RKQY 437
+++
Sbjct: 194 SERF 197
>UniRef50_A7I7L2 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=1; Candidatus
Methanoregula boonei 6A8|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Methanoregula
boonei (strain 6A8)
Length = 525
Score = 66.5 bits (155), Expect = 8e-10
Identities = 34/80 (42%), Positives = 48/80 (60%)
Frame = +2
Query: 11 TRAPEMLGGRVKTLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPD 190
T PEM+ GRVKTLHP VH G+L R D M + I ++V NLYPF + +S+
Sbjct: 82 TGFPEMMDGRVKTLHPKVHGGLLGR-RQIDDAIMAKYGINRIGLLVVNLYPF-ERMSRES 139
Query: 191 VTVADAVENIDIGGVTLLRA 250
+ + +E ID+GG ++RA
Sbjct: 140 LPLEKLIEYIDVGGPAMIRA 159
Score = 50.4 bits (115), Expect = 6e-05
Identities = 38/94 (40%), Positives = 46/94 (48%), Gaps = 10/94 (10%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRL--ALKAFTHTSDYDLAISD 419
A +KN V VV DP+DY VVK + N QRL A KAF T+ YD AIS+
Sbjct: 159 AAAKNFKDVAVVVDPSDYPEVVKTLSSN----VGFSHEQRLIFAKKAFARTAAYDAAISN 214
Query: 420 YFRKQYSPGQAQLT--------LRYGMNPHQKPA 497
+ + LT LRYG NPHQ+ A
Sbjct: 215 HLSNLDNTFPPILTLQFTNGRMLRYGENPHQQAA 248
>UniRef50_Q89B23 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=2; Buchnera aphidicola (Baizongia
pistaciae)|Rep: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Buchnera aphidicola subsp.
Baizongia pistaciae
Length = 529
Score = 64.9 bits (151), Expect = 3e-09
Identities = 29/80 (36%), Positives = 52/80 (65%)
Frame = +2
Query: 11 TRAPEMLGGRVKTLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPD 190
T PE++ GR+KTLH ++A ILA+ D++ +++ ++ +VV N YPF + + +
Sbjct: 58 TNFPEIMNGRIKTLHHKIYASILAQ-PKHDKKTIEKYNIILMDIVVINFYPFEEASNNTN 116
Query: 191 VTVADAVENIDIGGVTLLRA 250
+ + D +E+IDIGG ++RA
Sbjct: 117 LHLNDIIEHIDIGGPAIVRA 136
Score = 38.3 bits (85), Expect = 0.25
Identities = 22/63 (34%), Positives = 33/63 (52%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYF 425
A +KN+ V VV P Y ++V E+ N + + T+ + A AF HT +YD I Y
Sbjct: 136 AAAKNYKNVLVVTQPNLYQSIVNEMNLNNNIISET-TKLKFATIAFKHTMNYDNNIYQYL 194
Query: 426 RKQ 434
K+
Sbjct: 195 SKK 197
>UniRef50_Q316G8 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=4; Desulfovibrionaceae|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Desulfovibrio desulfuricans (strain
G20)
Length = 252
Score = 62.5 bits (145), Expect = 1e-08
Identities = 32/82 (39%), Positives = 47/82 (57%), Gaps = 1/82 (1%)
Frame = +2
Query: 8 ITRAPEMLGGRVKTLHPAVHAGILARLSDSDQ-EDMKRQKYEMISVVVCNLYPFVQTVSK 184
+T PE++GGRVKTLHP +H GILA + + +K ++ NLY F ++
Sbjct: 109 VTGFPEIMGGRVKTLHPHIHGGILADKDNPEHLATLKELGIRTFDLICVNLYNFADAAAR 168
Query: 185 PDVTVADAVENIDIGGVTLLRA 250
+ + AVE +DIGG +LRA
Sbjct: 169 -GLDLRGAVEEVDIGGPCMLRA 189
Score = 48.8 bits (111), Expect = 2e-04
Identities = 25/59 (42%), Positives = 37/59 (62%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDY 422
A +KN + V+ DPADY A ++E+++N + L RQ +A+K F TS YD I+DY
Sbjct: 189 ATAKNFHSMLVLPDPADYQAAMQEMRDN-DMRVGLAMRQAMAVKTFRATSAYDGMIADY 246
>UniRef50_A4MAE3 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=1; Petrotoga mobilis SJ95|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Petrotoga mobilis SJ95
Length = 489
Score = 62.1 bits (144), Expect = 2e-08
Identities = 34/78 (43%), Positives = 49/78 (62%), Gaps = 1/78 (1%)
Frame = +2
Query: 20 PEMLGGRVKTLHPAVHAGILARLSD-SDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVT 196
PE+LGGRVK++ P + GILA+ +D +EDM + I +VV N +P + ++K
Sbjct: 57 PEILGGRVKSIDPKLAGGILAKSNDKKHEEDMINYNIKRIDMVVGN-FPTFEEIAKKTKN 115
Query: 197 VADAVENIDIGGVTLLRA 250
+ENIDIGG +LLRA
Sbjct: 116 EETLLENIDIGGYSLLRA 133
Score = 45.6 bits (103), Expect = 0.002
Identities = 29/89 (32%), Positives = 44/89 (49%), Gaps = 7/89 (7%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYF 425
A +KN+ V + DP DY V+ +++ L R++LALK F TS YD +I F
Sbjct: 133 AAAKNYKDVVALADPKDYQTVIDNLEDCG--DVPLQLRRKLALKVFFSTSKYDASIHKIF 190
Query: 426 RKQYSPGQAQL-------TLRYGMNPHQK 491
+ ++ + LRYG NP Q+
Sbjct: 191 SELFAAEKFDHEFFEILGNLRYGSNPMQE 219
>UniRef50_Q6MIZ2 Cluster: IMP cyclohydrolase; n=1; Bdellovibrio
bacteriovorus|Rep: IMP cyclohydrolase - Bdellovibrio
bacteriovorus
Length = 507
Score = 61.3 bits (142), Expect = 3e-08
Identities = 36/89 (40%), Positives = 50/89 (56%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYF 425
A +KN VTV+CDP+ Y +KE N + TT RQ+ A +T T+ YD+AI+ +
Sbjct: 134 AGAKNFHSVTVLCDPSQYSEFLKEFNGN-NGSTTWEFRQKCAAAVYTMTAFYDMAIAGFL 192
Query: 426 RKQYSPGQAQLTLRYGMNPHQKPAQVFTP 512
+ + G A LRYG NPHQK + P
Sbjct: 193 TQ--NSGAA---LRYGENPHQKAVVLKDP 216
Score = 53.6 bits (123), Expect = 6e-06
Identities = 32/77 (41%), Positives = 42/77 (54%), Gaps = 1/77 (1%)
Frame = +2
Query: 23 EMLGGRVKTLHPAVHAGILARLSD-SDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTV 199
E GR+KT+ + + +L R D +D E I +VV NLYPF T+ K
Sbjct: 59 EAFNGRMKTISFEIASSLLFRRQDENDVRQAAELGIEPIDLVVVNLYPFHATLQK-QAGF 117
Query: 200 ADAVENIDIGGVTLLRA 250
+ +ENIDIGG TLLRA
Sbjct: 118 EECIENIDIGGPTLLRA 134
>UniRef50_Q7VRP9 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase, IMP cyclohydrolase and MGS-like
domain; n=2; Candidatus Blochmannia|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase, IMP cyclohydrolase and MGS-like
domain - Blochmannia floridanus
Length = 549
Score = 54.4 bits (125), Expect = 4e-06
Identities = 29/80 (36%), Positives = 45/80 (56%)
Frame = +2
Query: 11 TRAPEMLGGRVKTLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPD 190
T PE++ G+VKTLH + AGIL+R + D+ + + + I +V+ N YPF +
Sbjct: 58 TNFPEIMNGQVKTLHHKICAGILSR-KNLDESIIHKYGIQPIDMVIVNFYPFHLILQNKQ 116
Query: 191 VTVADAVENIDIGGVTLLRA 250
+E IDIGG ++RA
Sbjct: 117 HDSEKILEYIDIGGPNMVRA 136
Score = 54.4 bits (125), Expect(2) = 2e-07
Identities = 29/81 (35%), Positives = 42/81 (51%), Gaps = 2/81 (2%)
Frame = +3
Query: 246 AXSKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAISDYF 425
A +KN+ ++ D DYD ++ EI H +L TR LA KAF + YD ISDYF
Sbjct: 136 AAAKNYKNTVIIVDNNDYDNILNEIN-TLHGSISLNTRLNLAAKAFKYIKQYDTMISDYF 194
Query: 426 RKQ--YSPGQAQLTLRYGMNP 482
+ Q P + T++ + P
Sbjct: 195 QHQLKLQPNKPHHTIQKRIQP 215
Score = 23.8 bits (49), Expect(2) = 2e-07
Identities = 8/10 (80%), Positives = 9/10 (90%)
Frame = +3
Query: 459 TLRYGMNPHQ 488
T+RYG NPHQ
Sbjct: 237 TMRYGENPHQ 246
>UniRef50_A5B3D8 Cluster: DNA-directed RNA polymerase; n=1; Vitis
vinifera|Rep: DNA-directed RNA polymerase - Vitis
vinifera (Grape)
Length = 153
Score = 52.0 bits (119), Expect = 2e-05
Identities = 28/64 (43%), Positives = 32/64 (50%), Gaps = 1/64 (1%)
Frame = +2
Query: 26 MLGGRVKTLHPAVHAGILARLSDS-DQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVA 202
ML G VKTLHP +H GILAR E + VVV NLYPF VS +
Sbjct: 1 MLDGHVKTLHPNIHGGILARRDQKHHMEALNEHGIGTFDVVVVNLYPFYDKVSLGGIEFE 60
Query: 203 DAVE 214
D +E
Sbjct: 61 DEIE 64
>UniRef50_Q95QQ5 Cluster: Putative uncharacterized protein; n=2;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 420
Score = 51.2 bits (117), Expect = 3e-05
Identities = 20/34 (58%), Positives = 26/34 (76%)
Frame = +2
Query: 521 LPITTLNGAPGFINLCDALNAWQLVKELKEALNL 622
+PI LNG+PG+IN+ D LN WQLVKEL +A +
Sbjct: 1 MPIKVLNGSPGYINILDGLNGWQLVKELSDATKM 34
Score = 48.0 bits (109), Expect = 3e-04
Identities = 21/26 (80%), Positives = 23/26 (88%)
Frame = +1
Query: 637 AFKHVSPAGAAVGLPLTDEEAAVCMV 714
+FKHVSPAGAAVGLPL + EAA CMV
Sbjct: 39 SFKHVSPAGAAVGLPLNETEAACCMV 64
>UniRef50_A1G3C3 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=1; Salinispora arenicola
CNS205|Rep: Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Salinispora arenicola CNS205
Length = 190
Score = 50.4 bits (115), Expect = 6e-05
Identities = 29/77 (37%), Positives = 42/77 (54%)
Frame = +2
Query: 20 PEMLGGRVKTLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTV 199
P +LGGRVKTL ++ GILAR +D+ +++R + +V CN Y +P
Sbjct: 54 PTLLGGRVKTLTVSLMGGILARDEPADRAEVERHGLTRVHLVCCNYYRLPD--PQPAQPF 111
Query: 200 ADAVENIDIGGVTLLRA 250
E ID+GG +LRA
Sbjct: 112 ERFRELIDVGGPAMLRA 128
>UniRef50_A7PK27 Cluster: Chromosome chr15 scaffold_19, whole genome
shotgun sequence; n=1; Vitis vinifera|Rep: Chromosome
chr15 scaffold_19, whole genome shotgun sequence - Vitis
vinifera (Grape)
Length = 227
Score = 44.4 bits (100), Expect = 0.004
Identities = 25/65 (38%), Positives = 33/65 (50%), Gaps = 1/65 (1%)
Frame = +2
Query: 8 ITRAPEMLGGRVKTLHPAVHAGILARLSDS-DQEDMKRQKYEMISVVVCNLYPFVQTVSK 184
+T P++L G VKTLHP + GIL R E + VVV NLYPF +
Sbjct: 71 LTCFPKILDGHVKTLHPNIQGGILPRRDQKHHMEALNEHGIGTFDVVVVNLYPFYD--KQ 128
Query: 185 PDVTV 199
P +T+
Sbjct: 129 PKLTI 133
>UniRef50_Q0YKD5 Cluster: IMP cyclohydrolase; n=2; Geobacter|Rep:
IMP cyclohydrolase - Geobacter sp. FRC-32
Length = 388
Score = 43.6 bits (98), Expect = 0.007
Identities = 21/53 (39%), Positives = 31/53 (58%), Gaps = 1/53 (1%)
Frame = +2
Query: 458 DLKIRYEPTSEAGPG-IHTRDSLPITTLNGAPGFINLCDALNAWQLVKELKEA 613
++K++Y S P + ++ LNG P +IN+ DAL AWQL +ELK A
Sbjct: 2 EIKLKYGCNSHQTPANLIIPENSGFQVLNGTPSYINILDALGAWQLARELKIA 54
>UniRef50_Q3JNS9 Cluster: Putative uncharacterized protein; n=9;
Burkholderia|Rep: Putative uncharacterized protein -
Burkholderia pseudomallei (strain 1710b)
Length = 917
Score = 43.2 bits (97), Expect = 0.009
Identities = 23/34 (67%), Positives = 24/34 (70%)
Frame = -3
Query: 247 AQEGHAADVDVLDRVRHGHVRLRYRLDERVQVTD 146
AQ AADVDVLDRV V LR RLDER+QV D
Sbjct: 723 AQHRRAADVDVLDRVGERAVVLRNRLDERIQVHD 756
>UniRef50_A4M1L4 Cluster: Putative uncharacterized protein; n=1;
Geobacter bemidjiensis Bem|Rep: Putative uncharacterized
protein - Geobacter bemidjiensis Bem
Length = 546
Score = 39.9 bits (89), Expect = 0.082
Identities = 19/36 (52%), Positives = 23/36 (63%)
Frame = -3
Query: 247 AQEGHAADVDVLDRVRHGHVRLRYRLDERVQVTDHH 140
A+ G AAD+DVLD + HG V R ERV+V HH
Sbjct: 412 AEHGRAADIDVLDGILHGAVLFRDGRLERVEVYHHH 447
>UniRef50_A1HBX2 Cluster: Putative uncharacterized protein; n=2;
Ralstonia pickettii|Rep: Putative uncharacterized
protein - Ralstonia pickettii 12J
Length = 699
Score = 36.3 bits (80), Expect = 1.0
Identities = 22/36 (61%), Positives = 23/36 (63%)
Frame = -3
Query: 247 AQEGHAADVDVLDRVRHGHVRLRYRLDERVQVTDHH 140
AQ G AADVDVLD V L +RL ERVQV HH
Sbjct: 434 AQHGRAADVDVLDGVGQRAFVLGHRLLERVQV--HH 467
>UniRef50_Q4RM56 Cluster: Chromosome 10 SCAF15019, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 10 SCAF15019, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 166
Score = 35.5 bits (78), Expect = 1.8
Identities = 21/56 (37%), Positives = 26/56 (46%), Gaps = 7/56 (12%)
Frame = +1
Query: 502 YSHQRQLADHDTERCAWIY-QPVRRAERLAARQGAEGSAEP------FLLRLAFKH 648
Y QL H TE+C W+ R ER+ R GA G + P F LR+ F H
Sbjct: 97 YGSAHQLPRHQTEQCHWLQGSKDSRTERVPRRPGATGRSVPTQKRATFSLRVGFNH 152
>UniRef50_A6SGW5 Cluster: Putative uncharacterized protein; n=2;
Sclerotiniaceae|Rep: Putative uncharacterized protein -
Botryotinia fuckeliana B05.10
Length = 653
Score = 34.3 bits (75), Expect = 4.1
Identities = 26/75 (34%), Positives = 39/75 (52%), Gaps = 2/75 (2%)
Frame = +3
Query: 345 TLGTRQRLALKAFTHTSDYDLAISDYFRKQYSPGQAQLTLRYGMNPHQKPAQVFTP--ET 518
T+ R+RLAL FT S + +A+ Y+R QYSP ++ LR +KP + P
Sbjct: 3 TIALRKRLAL-LFT-VSSFTIALIYYWRLQYSPQISEERLRPKPVIPEKPGLIKEPPGHD 60
Query: 519 ACRSRH*TVRLDLST 563
+ +H T +D ST
Sbjct: 61 DAKLQHSTASIDTST 75
>UniRef50_Q6AGB7 Cluster: Flagellar hook-associated protein 3; n=1;
Leifsonia xyli subsp. xyli|Rep: Flagellar
hook-associated protein 3 - Leifsonia xyli subsp. xyli
Length = 290
Score = 33.1 bits (72), Expect = 9.4
Identities = 17/46 (36%), Positives = 23/46 (50%)
Frame = +3
Query: 273 TVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLA 410
T PA+ D++VK I++ K + L Q L F TSD D A
Sbjct: 102 TGTSSPANQDSIVKSIEQLKQNLLALANTQYLGRSVFAGTSDADTA 147
>UniRef50_A5B1A5 Cluster: DNA-directed RNA polymerase; n=1; Vitis
vinifera|Rep: DNA-directed RNA polymerase - Vitis
vinifera (Grape)
Length = 202
Score = 33.1 bits (72), Expect = 9.4
Identities = 14/26 (53%), Positives = 18/26 (69%)
Frame = +2
Query: 8 ITRAPEMLGGRVKTLHPAVHAGILAR 85
+T P++L G VKTLHP + GIL R
Sbjct: 71 LTCFPKILDGHVKTLHPNIQGGILPR 96
>UniRef50_Q9X0X6 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=4; Thermotogaceae|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Thermotoga maritima
Length = 452
Score = 33.1 bits (72), Expect = 9.4
Identities = 15/24 (62%), Positives = 17/24 (70%)
Frame = +2
Query: 8 ITRAPEMLGGRVKTLHPAVHAGIL 79
IT +LGG VKTLHP + AGIL
Sbjct: 51 ITGFENLLGGLVKTLHPEIFAGIL 74
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 778,404,802
Number of Sequences: 1657284
Number of extensions: 14192817
Number of successful extensions: 45291
Number of sequences better than 10.0: 59
Number of HSP's better than 10.0 without gapping: 43366
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 45186
length of database: 575,637,011
effective HSP length: 100
effective length of database: 409,908,611
effective search space used: 77472727479
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
- SilkBase 1999-2023 -