Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fbpv0251
(774 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q4SHT8 Cluster: Chromosome 5 SCAF14581, whole genome sh... 114 2e-24
UniRef50_P31939 Cluster: Bifunctional purine biosynthesis protei... 107 4e-22
UniRef50_Q73LG8 Cluster: Phosphoribosylaminoimidazolecarboxamide... 82 2e-14
UniRef50_Q2JI00 Cluster: Bifunctional purine biosynthesis protei... 82 2e-14
UniRef50_P74741 Cluster: Bifunctional purine biosynthesis protei... 79 9e-14
UniRef50_Q2JR47 Cluster: Bifunctional purine biosynthesis protei... 79 2e-13
UniRef50_Q8PYG4 Cluster: Formyltransferase phosphoribosylaminoim... 78 2e-13
UniRef50_P67543 Cluster: Bifunctional purine biosynthesis protei... 78 3e-13
UniRef50_P43852 Cluster: Bifunctional purine biosynthesis protei... 77 4e-13
UniRef50_Q550I9 Cluster: AICAR transformylase / IMP cyclohydrola... 76 1e-12
UniRef50_Q8ZAR3 Cluster: Bifunctional purine biosynthesis protei... 74 3e-12
UniRef50_P12048 Cluster: Bifunctional purine biosynthesis protei... 73 6e-12
UniRef50_A1K9K5 Cluster: Phosphoribosylaminoimidazolecarboxamide... 72 1e-11
UniRef50_Q8F3W6 Cluster: Bifunctional purine biosynthesis protei... 72 2e-11
UniRef50_A5E8X1 Cluster: Phosphoribosylaminoimidazolecarboxamide... 71 3e-11
UniRef50_Q83EI4 Cluster: Phosphoribosylaminoimidazolecarboxamide... 71 4e-11
UniRef50_Q6MIZ2 Cluster: IMP cyclohydrolase; n=1; Bdellovibrio b... 68 3e-10
UniRef50_A7HM64 Cluster: IMP cyclohydrolase; n=1; Fervidobacteri... 68 3e-10
UniRef50_UPI00015BCE7E Cluster: UPI00015BCE7E related cluster; n... 67 5e-10
UniRef50_Q9PC10 Cluster: Bifunctional purine biosynthesis protei... 66 9e-10
UniRef50_Q1V178 Cluster: Bifunctional purine biosynthesis protei... 65 2e-09
UniRef50_Q8CXK7 Cluster: Bifunctional purine biosynthesis protei... 65 2e-09
UniRef50_Q7X311 Cluster: Putative AICAR transformylase; n=1; unc... 65 2e-09
UniRef50_Q8D244 Cluster: Bifunctional purine biosynthesis protei... 65 2e-09
UniRef50_Q9FPL3 Cluster: Phosphoribosylaminoimidazolecarboxamide... 64 3e-09
UniRef50_Q9F1T4 Cluster: Bifunctional purine biosynthesis protei... 64 5e-09
UniRef50_A6G003 Cluster: Bifunctional phosphoribosylaminoimidazo... 62 2e-08
UniRef50_A7BET6 Cluster: Putative uncharacterized protein; n=1; ... 61 3e-08
UniRef50_O67775 Cluster: Bifunctional purine biosynthesis protei... 60 6e-08
UniRef50_A0JTW4 Cluster: Phosphoribosylaminoimidazolecarboxamide... 60 8e-08
UniRef50_Q9RW01 Cluster: Bifunctional purine biosynthesis protei... 59 1e-07
UniRef50_A2SS05 Cluster: Phosphoribosylaminoimidazolecarboxamide... 58 2e-07
UniRef50_A7DF55 Cluster: Phosphoribosylaminoimidazolecarboxamide... 57 4e-07
UniRef50_Q6L122 Cluster: Phosphoribosylaminoimidazolecarboxamide... 57 4e-07
UniRef50_Q8XMK2 Cluster: Bifunctional purine biosynthesis protei... 57 4e-07
UniRef50_A7I7L2 Cluster: Phosphoribosylaminoimidazolecarboxamide... 56 1e-06
UniRef50_Q89B23 Cluster: Bifunctional purine biosynthesis protei... 54 4e-06
UniRef50_Q83GZ1 Cluster: Phosphoribosylaminoimidazolecarboxamide... 54 5e-06
UniRef50_A4MAE3 Cluster: Phosphoribosylaminoimidazolecarboxamide... 52 1e-05
UniRef50_Q9PNY2 Cluster: Bifunctional purine biosynthesis protei... 52 1e-05
UniRef50_A1IEQ8 Cluster: IMP cyclohydrolase; n=1; Candidatus Des... 52 2e-05
UniRef50_Q7VRP9 Cluster: Phosphoribosylaminoimidazolecarboxamide... 51 4e-05
UniRef50_Q316G8 Cluster: Phosphoribosylaminoimidazolecarboxamide... 50 6e-05
UniRef50_Q8G6B1 Cluster: Bifunctional purine biosynthesis protei... 49 1e-04
UniRef50_Q7MUT5 Cluster: Phosphoribosylaminoimidazolecarboxamide... 45 0.002
UniRef50_A1G3C3 Cluster: Phosphoribosylaminoimidazolecarboxamide... 38 0.21
UniRef50_Q9X0X6 Cluster: Bifunctional purine biosynthesis protei... 36 0.85
UniRef50_Q8A155 Cluster: Bifunctional purine biosynthesis protei... 36 0.85
UniRef50_Q3JNS9 Cluster: Putative uncharacterized protein; n=9; ... 35 2.0
UniRef50_A4M1L4 Cluster: Putative uncharacterized protein; n=1; ... 35 2.0
UniRef50_A5B3D8 Cluster: DNA-directed RNA polymerase; n=1; Vitis... 33 6.0
UniRef50_UPI0000382898 Cluster: COG0138: AICAR transformylase/IM... 33 7.9
UniRef50_A5KA45 Cluster: Putative uncharacterized protein; n=2; ... 33 7.9
UniRef50_O28464 Cluster: Inosine monophosphate cyclohydrolase; n... 33 7.9
>UniRef50_Q4SHT8 Cluster: Chromosome 5 SCAF14581, whole genome
shotgun sequence; n=3; Euteleostomi|Rep: Chromosome 5
SCAF14581, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 628
Score = 114 bits (275), Expect = 2e-24
Identities = 69/131 (52%), Positives = 80/131 (61%), Gaps = 3/131 (2%)
Frame = +1
Query: 58 ALLSVSDKTGLLSLAKSLSECGLQLIASXGTATX---ASERXPHSSRCVGHHESTGDARR 228
ALLSVSDKTGL+ AK L + GL L+AS GTA A S GH E G +
Sbjct: 1 ALLSVSDKTGLVQFAKRLVDVGLSLVASGGTAKTLRDAGWAVRDVSELTGHPEMLGGRVK 60
Query: 229 SGENFTSSGHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVEN 408
+ + H GILAR S +D DM++ Y +I VVVCNLYPFV +VS VTV DAVE
Sbjct: 61 T---LHPAVHGGILARKSPADTADMEKLGYSLIRVVVCNLYPFVKTVSNPSVTVEDAVEQ 117
Query: 409 IDIGXVTLLRA 441
IDIG VTLLRA
Sbjct: 118 IDIGGVTLLRA 128
Score = 34.7 bits (76), Expect = 2.6
Identities = 15/22 (68%), Positives = 16/22 (72%)
Frame = +3
Query: 444 AKXHDRVTVVCXPADYDAVVKE 509
AK H RVTVVC PADY V +E
Sbjct: 130 AKNHARVTVVCDPADYPRVAEE 151
>UniRef50_P31939 Cluster: Bifunctional purine biosynthesis protein
PURH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3)
(5-aminoimidazole-4-carboxamide ribonucleotide
formyltransferase) (AICAR transformylase); IMP
cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=105; cellular organisms|Rep:
Bifunctional purine biosynthesis protein PURH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3)
(5-aminoimidazole-4-carboxamide ribonucleotide
formyltransferase) (AICAR transformylase); IMP
cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Homo sapiens (Human)
Length = 592
Score = 107 bits (256), Expect = 4e-22
Identities = 65/134 (48%), Positives = 79/134 (58%), Gaps = 3/134 (2%)
Frame = +1
Query: 49 GKLALLSVSDKTGLLSLAKSLSECGLQLIASXGTATX---ASERXPHSSRCVGHHESTGD 219
G+LAL SVSDKTGL+ A++L+ GL L+AS GTA A S G E G
Sbjct: 4 GQLALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEMLGG 63
Query: 220 ARRSGENFTSSGHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADA 399
++ + HAGILAR D DM R + +I VV CNLYPFV +V+ VTV +A
Sbjct: 64 RVKT---LHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEA 120
Query: 400 VENIDIGXVTLLRA 441
VE IDIG VTLLRA
Sbjct: 121 VEQIDIGGVTLLRA 134
Score = 45.6 bits (103), Expect = 0.001
Identities = 27/63 (42%), Positives = 31/63 (49%)
Frame = +3
Query: 444 AKXHDRVTVVCXPADYDAVVKESKRTNIIRRLWAQGRD*P*RRFTHTSDYGPRHIRDYFR 623
AK H RVTVVC P DY V E + + R + FTHT+ Y I DYFR
Sbjct: 136 AKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFTHTAQY-DEAISDYFR 194
Query: 624 KXY 632
K Y
Sbjct: 195 KQY 197
Score = 35.5 bits (78), Expect = 1.5
Identities = 21/60 (35%), Positives = 35/60 (58%)
Frame = +2
Query: 500 SQRIKENKHHQTTLGTRQRLALKAFHSYFGLWTSPYSGLLPQAILRXGQAQLTLRYGMNP 679
S ++ ++ T+L TR++LALKAF ++ + S + + G +Q+ LRYGMNP
Sbjct: 155 STEMQSSESKDTSLETRRQLALKAF-THTAQYDEAISDYFRKQYSK-GVSQMPLRYGMNP 212
>UniRef50_Q73LG8 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=2; Bacteria|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Treponema
denticola
Length = 533
Score = 81.8 bits (193), Expect = 2e-14
Identities = 50/129 (38%), Positives = 63/129 (48%)
Frame = +1
Query: 55 LALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASERXPHSSRCVGHHESTGDARRSG 234
L L SVSDKTGL A L G IAS GTA E + S
Sbjct: 3 LVLASVSDKTGLKDFAFRLKAAGYDFIASGGTAKTLQEAGIKVKEVSEYTSSPEILGGRV 62
Query: 235 ENFTSSGHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVENID 414
+ H GILAR + D+ ++K + I +V+ NLYPF ++S T +D +ENID
Sbjct: 63 KTLHPMIHGGILARDTKEDRAELKALGFSGIDIVIANLYPFEKTISSPDSTESDCIENID 122
Query: 415 IGXVTLLRA 441
IG V LLRA
Sbjct: 123 IGGVALLRA 131
Score = 37.1 bits (82), Expect = 0.49
Identities = 16/29 (55%), Positives = 20/29 (68%)
Frame = +3
Query: 444 AKXHDRVTVVCXPADYDAVVKESKRTNII 530
AK + RVTV+C PADYD V E ++T I
Sbjct: 133 AKNYSRVTVICDPADYDEVSSEIEKTGEI 161
>UniRef50_Q2JI00 Cluster: Bifunctional purine biosynthesis protein
PurH; n=1; Synechococcus sp. JA-2-3B'a(2-13)|Rep:
Bifunctional purine biosynthesis protein PurH -
Synechococcus sp. (strain JA-2-3B'a(2-13))
(Cyanobacteria bacteriumYellowstone B-Prime)
Length = 577
Score = 81.8 bits (193), Expect = 2e-14
Identities = 56/131 (42%), Positives = 72/131 (54%), Gaps = 2/131 (1%)
Frame = +1
Query: 55 LALLSVSDKTGLLSLAKSL-SECGLQLIASXGTATXASERXPHSSRCVGHHESTGDARRS 231
LALLSVSDKTGL+ LA+SL E G QL++S GTA SE + H +
Sbjct: 17 LALLSVSDKTGLIPLAQSLVQEHGFQLLSSGGTAKALSEAGIPVTPVSAHTGAPEILGGR 76
Query: 232 GENFTSSGHAGILARLSDS-DQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVEN 408
+ H GILARL S D+ D++ I +VV N YPF +V+ V++ +A E
Sbjct: 77 VKTLHPRIHGGILARLECSEDRADLEALGIPPIQLVVVNFYPFEQTVAQAGVSLEEAFEQ 136
Query: 409 IDIGXVTLLRA 441
IDIG TL RA
Sbjct: 137 IDIGGPTLARA 147
Score = 41.9 bits (94), Expect = 0.017
Identities = 20/32 (62%), Positives = 23/32 (71%)
Frame = +2
Query: 155 RXLRNAGLTVQDVSDITRAPEMLGGRVKTLHP 250
+ L AG+ V VS T APE+LGGRVKTLHP
Sbjct: 51 KALSEAGIPVTPVSAHTGAPEILGGRVKTLHP 82
>UniRef50_P74741 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=49; root|Rep: Bifunctional purine
biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Synechocystis sp. (strain PCC
6803)
Length = 511
Score = 79.4 bits (187), Expect = 9e-14
Identities = 51/132 (38%), Positives = 73/132 (55%), Gaps = 2/132 (1%)
Frame = +1
Query: 52 KLALLSVSDKTGLLSLAKSL-SECGLQLIASXGTATXASERXPHSSRCVGHHESTGDARR 228
+LALLSVSDK+G++ LA+ L +E LI+S GTA E ++ + +
Sbjct: 3 RLALLSVSDKSGIVELAQRLVNEFQFDLISSGGTAKTLKEAGVPVTKVSDYTGAPEILGG 62
Query: 229 SGENFTSSGHAGILARLS-DSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVE 405
+ H GILAR SDQ D++ + +VV NLYPF +++ VTVA+AVE
Sbjct: 63 RVKTLHPRIHGGILARRDLPSDQADLEANDIRPLDLVVVNLYPFEQTIAKPGVTVAEAVE 122
Query: 406 NIDIGXVTLLRA 441
IDIG ++RA
Sbjct: 123 QIDIGGPAMIRA 134
>UniRef50_Q2JR47 Cluster: Bifunctional purine biosynthesis protein
PurH; n=12; Bacteria|Rep: Bifunctional purine
biosynthesis protein PurH - Synechococcus sp. (strain
JA-3-3Ab) (Cyanobacteria bacteriumYellowstone A-Prime)
Length = 537
Score = 78.6 bits (185), Expect = 2e-13
Identities = 54/131 (41%), Positives = 71/131 (54%), Gaps = 2/131 (1%)
Frame = +1
Query: 55 LALLSVSDKTGLLSLAKSL-SECGLQLIASXGTATXASERXPHSSRCVGHHESTGDARRS 231
LALLSVSDKTGL+ LA++L E G QL++S GTA SE + H +
Sbjct: 9 LALLSVSDKTGLIPLAQALVQEHGFQLLSSGGTAKALSEAGIPVTPVSEHTGAPEILGGR 68
Query: 232 GENFTSSGHAGILARLSD-SDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVEN 408
+ H GILARL D+ D++ I +VV N YPF +V+ V++ +A E
Sbjct: 69 VKTLHPRIHGGILARLERREDRADLEALGIPPIQLVVVNFYPFEQTVARAGVSLEEAFEQ 128
Query: 409 IDIGXVTLLRA 441
IDIG TL RA
Sbjct: 129 IDIGGPTLARA 139
Score = 43.6 bits (98), Expect = 0.006
Identities = 20/32 (62%), Positives = 24/32 (75%)
Frame = +2
Query: 155 RXLRNAGLTVQDVSDITRAPEMLGGRVKTLHP 250
+ L AG+ V VS+ T APE+LGGRVKTLHP
Sbjct: 43 KALSEAGIPVTPVSEHTGAPEILGGRVKTLHP 74
>UniRef50_Q8PYG4 Cluster: Formyltransferase
phosphoribosylaminoimidazolecarboxamide; n=4;
Methanosarcinaceae|Rep: Formyltransferase
phosphoribosylaminoimidazolecarboxamide - Methanosarcina
mazei (Methanosarcina frisia)
Length = 538
Score = 78.2 bits (184), Expect = 2e-13
Identities = 49/134 (36%), Positives = 72/134 (53%), Gaps = 4/134 (2%)
Frame = +1
Query: 52 KLALLSVSDKTGLLSLAKSLSECGLQLIASXGTATX---ASERXPHSSRCVGHHESTGDA 222
K ALLSVSDKTG++ A+ L G+++I++ GTA A S G+ E G
Sbjct: 3 KRALLSVSDKTGIVEFARGLEALGVKIISTGGTAKILRDADIEVTDVSEVTGYPEMMGGR 62
Query: 223 RRSGENFTSSGHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADA 399
++ H G+L R S E+ ++ +I ++ NLYPF +VS V + +A
Sbjct: 63 VKT---LHPRIHGGLLCLRESKEQMEEAAKEDISLIDLIAVNLYPFEITVSRENVELEEA 119
Query: 400 VENIDIGXVTLLRA 441
+ENIDIG TLLR+
Sbjct: 120 IENIDIGGPTLLRS 133
>UniRef50_P67543 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=18; Staphylococcus|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Staphylococcus aureus (strain Mu50
/ ATCC 700699)
Length = 492
Score = 77.8 bits (183), Expect = 3e-13
Identities = 50/133 (37%), Positives = 74/133 (55%), Gaps = 3/133 (2%)
Frame = +1
Query: 52 KLALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASE-RXP-HSSRCVGHHESTGDAR 225
K A+LSVS+KTG++ AK+L++ +L ++ GT E P S + H D R
Sbjct: 2 KKAILSVSNKTGIVEFAKALTQLNYELYSTGGTKRILDEANVPVRSVSDLTHFPEIMDGR 61
Query: 226 RSGENFTSSGHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAV 402
+ + H GILA R ++ Q ++I +VV NLYPF +V+ VT+ +A+
Sbjct: 62 V--KTLHPAVHGGILADRNKPQHLNELSEQHIDLIDMVVVNLYPFQQTVANPDVTMDEAI 119
Query: 403 ENIDIGXVTLLRA 441
ENIDIG T+LRA
Sbjct: 120 ENIDIGGPTMLRA 132
>UniRef50_P43852 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=88; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Haemophilus influenzae
Length = 532
Score = 77.4 bits (182), Expect = 4e-13
Identities = 54/131 (41%), Positives = 74/131 (56%), Gaps = 3/131 (2%)
Frame = +1
Query: 58 ALLSVSDKTGLLSLAKSLSECGLQLIASXGTATX-ASERXP--HSSRCVGHHESTGDARR 228
ALLSVSDKTG++ A+ L + G++L+++ GTA A P S G E D R
Sbjct: 9 ALLSVSDKTGIVEFAQGLVKRGVKLLSTGGTAKLLAQNALPVIEVSDYTGFPEMM-DGRV 67
Query: 229 SGENFTSSGHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVEN 408
+ H GIL R +D M++ E I +VV NLYPF +V+ T+ADAVEN
Sbjct: 68 --KTLHPKVHGGILGRRG-TDDAIMQQHGIEGIDMVVVNLYPFAATVAKPDCTLADAVEN 124
Query: 409 IDIGXVTLLRA 441
IDIG T++R+
Sbjct: 125 IDIGGPTMVRS 135
>UniRef50_Q550I9 Cluster: AICAR transformylase / IMP cyclohydrolase;
n=2; Dictyostelium discoideum|Rep: AICAR transformylase
/ IMP cyclohydrolase - Dictyostelium discoideum AX4
Length = 542
Score = 75.8 bits (178), Expect = 1e-12
Identities = 48/132 (36%), Positives = 70/132 (53%), Gaps = 1/132 (0%)
Frame = +1
Query: 58 ALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASERXPHSSRCVGHHESTGDARRSGE 237
ALLSV +K+G++ +K LS G LI++ GTA + + E +
Sbjct: 3 ALLSVYNKSGIVEFSKILSSKGFNLISTGGTAKSLVDNGLKVQQVSDVTEYPEMLDGRVK 62
Query: 238 NFTSSGHAGILARLSDSD-QEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVENID 414
H G+LAR + Q D+ + + IS+VV NLYPFV +VS T+ +A+ENID
Sbjct: 63 TLHPKIHGGLLARPELAHHQADLNKYNIKPISIVVVNLYPFVETVSKESTTLEEAIENID 122
Query: 415 IGXVTLLRAQPR 450
IG TL+RA +
Sbjct: 123 IGGHTLIRASSK 134
>UniRef50_Q8ZAR3 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=59; Proteobacteria|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Yersinia pestis
Length = 529
Score = 74.1 bits (174), Expect = 3e-12
Identities = 49/131 (37%), Positives = 72/131 (54%), Gaps = 3/131 (2%)
Frame = +1
Query: 58 ALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASERX---PHSSRCVGHHESTGDARR 228
ALLSVSDK G++ A++LS+ G++L+++ GTA ++ S G E D R
Sbjct: 10 ALLSVSDKAGIIEFAQALSQRGIELLSTGGTARLLADAGLPVTEVSDYTGFPEMM-DGRV 68
Query: 229 SGENFTSSGHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVEN 408
+ H GIL R D M + + I +VV NLYPF +V+ ++ DAVEN
Sbjct: 69 --KTLHPKVHGGILGRRGQDDGI-MAQHGIQPIDIVVVNLYPFAQTVARPDCSLEDAVEN 125
Query: 409 IDIGXVTLLRA 441
IDIG T++R+
Sbjct: 126 IDIGGPTMVRS 136
>UniRef50_P12048 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=71; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Bacillus subtilis
Length = 512
Score = 73.3 bits (172), Expect = 6e-12
Identities = 50/134 (37%), Positives = 72/134 (53%), Gaps = 4/134 (2%)
Frame = +1
Query: 52 KLALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASERXPHSSRCVGHHESTGDAR-R 228
K AL+SVSDKT L+ K L+E G+++I++ GT E + +G E TG
Sbjct: 4 KRALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQE---NGVDVIGISEVTGFPEIM 60
Query: 229 SGENFT--SSGHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADA 399
G T + H G+LA R ++ + + I +VV NLYPF ++S VT +A
Sbjct: 61 DGRLKTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVNLYPFKETISKEDVTYEEA 120
Query: 400 VENIDIGXVTLLRA 441
+ENIDIG +LRA
Sbjct: 121 IENIDIGGPGMLRA 134
>UniRef50_A1K9K5 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=2; Bacteria|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Azoarcus sp.
(strain BH72)
Length = 527
Score = 72.1 bits (169), Expect = 1e-11
Identities = 45/129 (34%), Positives = 67/129 (51%), Gaps = 1/129 (0%)
Frame = +1
Query: 58 ALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASERXPHSSRCVGHHESTGDARRSGE 237
AL+SVSDK G+L A+ L+ G++L+++ GTA + + H +
Sbjct: 6 ALISVSDKRGVLDFARELAGLGIKLLSTGGTAALLRDAGLPVTDVSEHTGFPEMLDGRVK 65
Query: 238 NFTSSGHAGILARLSDSDQED-MKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVENID 414
H GILAR ++ D + I +VV NLYPF +V+ T+ DA+ENID
Sbjct: 66 TLHPKVHGGILARRDLAEHMDTIAAHDISRIDLVVVNLYPFQATVARPDCTLEDAIENID 125
Query: 415 IGXVTLLRA 441
IG T++RA
Sbjct: 126 IGGPTMVRA 134
Score = 46.0 bits (104), Expect = 0.001
Identities = 22/30 (73%), Positives = 24/30 (80%)
Frame = +2
Query: 161 LRNAGLTVQDVSDITRAPEMLGGRVKTLHP 250
LR+AGL V DVS+ T PEML GRVKTLHP
Sbjct: 40 LRDAGLPVTDVSEHTGFPEMLDGRVKTLHP 69
>UniRef50_Q8F3W6 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=6; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Leptospira interrogans
Length = 511
Score = 71.7 bits (168), Expect = 2e-11
Identities = 46/136 (33%), Positives = 78/136 (57%), Gaps = 6/136 (4%)
Frame = +1
Query: 52 KLALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASERXPHSSRCVGHHESTG----- 216
K AL+SVSDK+GL+ AK L++ G+++I++ GT + + + + TG
Sbjct: 5 KRALISVSDKSGLVEFAKFLNQNGVEIISTGGTLKLLKD---NGIAAIAIDDYTGFPEIL 61
Query: 217 DARRSGENFTSSGHAGILARLSD-SDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVA 393
D R + H G+L +S+ + ++ M+ K I +VV NLYPF+ +VS V +
Sbjct: 62 DGR--VKTLHPKVHGGLLGVISNPAHKQKMEELKIPKIDLVVVNLYPFLKTVSKPEVQLE 119
Query: 394 DAVENIDIGXVTLLRA 441
+A+ENIDIG +++R+
Sbjct: 120 EAIENIDIGGPSMIRS 135
>UniRef50_A5E8X1 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase /IMP cyclohydrolase; n=4;
Bacteria|Rep: Phosphoribosylaminoimidazolecarboxamide
formyltransferase /IMP cyclohydrolase - Bradyrhizobium
sp. (strain BTAi1 / ATCC BAA-1182)
Length = 530
Score = 70.9 bits (166), Expect = 3e-11
Identities = 52/132 (39%), Positives = 70/132 (53%), Gaps = 4/132 (3%)
Frame = +1
Query: 58 ALLSVSDKTGLLSLAKSLSECGLQLIASXGTA---TXASERXPHSSRCVGHHESTGDARR 228
ALLSVSDKTGL+ A+SL+ G++LI++ GTA A + S G E D R
Sbjct: 11 ALLSVSDKTGLVEFARSLAARGIELISTGGTAKAIADAGLKVKDVSDLTGFPEMM-DGR- 68
Query: 229 SGENFTSSGHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVE 405
+ H G+LA R +D E MK I ++V NLYPF +V +D +E
Sbjct: 69 -VKTLHPKVHGGLLAIRGNDEHAEAMKTHGIAPIDLLVVNLYPFEATVE-RSAPFSDCIE 126
Query: 406 NIDIGXVTLLRA 441
NIDIG ++RA
Sbjct: 127 NIDIGGPAMIRA 138
Score = 46.8 bits (106), Expect = 6e-04
Identities = 20/32 (62%), Positives = 26/32 (81%)
Frame = +2
Query: 155 RXLRNAGLTVQDVSDITRAPEMLGGRVKTLHP 250
+ + +AGL V+DVSD+T PEM+ GRVKTLHP
Sbjct: 43 KAIADAGLKVKDVSDLTGFPEMMDGRVKTLHP 74
>UniRef50_Q83EI4 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=5; Coxiella
burnetii|Rep: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Coxiella burnetii
Length = 526
Score = 70.5 bits (165), Expect = 4e-11
Identities = 48/133 (36%), Positives = 70/133 (52%), Gaps = 3/133 (2%)
Frame = +1
Query: 52 KLALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASERXPHSSRCVGHHESTGDAR-R 228
K AL+S +DK GL+ L CG+++IA+ GTA + H + TG
Sbjct: 12 KRALISTADKIGLIEFISQLVTCGVEIIATGGTAELLKQ---HQLPVIDVFTYTGFPEIM 68
Query: 229 SGENFTSSG--HAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAV 402
G T HAG+LAR D++ + + + I ++V NLYPFV +VS ++ AV
Sbjct: 69 DGRVKTLHPKIHAGLLARRG-IDEKTLDQHAIKPIDLLVVNLYPFVQTVSASNCSLEKAV 127
Query: 403 ENIDIGXVTLLRA 441
E IDIG ++LRA
Sbjct: 128 EQIDIGGPSMLRA 140
>UniRef50_Q6MIZ2 Cluster: IMP cyclohydrolase; n=1; Bdellovibrio
bacteriovorus|Rep: IMP cyclohydrolase - Bdellovibrio
bacteriovorus
Length = 507
Score = 67.7 bits (158), Expect = 3e-10
Identities = 51/130 (39%), Positives = 66/130 (50%), Gaps = 2/130 (1%)
Frame = +1
Query: 58 ALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASERXPHSSRCVGHHESTGDARRSGE 237
ALLSVSDKTGLL LAK+L+ ++LIAS GTA +E + V G+A
Sbjct: 7 ALLSVSDKTGLLELAKNLAAQNVELIASGGTAKALTEAGLKVT-AVETLSGKGEAFNGRM 65
Query: 238 NFTSSGHAG--ILARLSDSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVENI 411
S A + R ++D E I +VV NLYPF ++ + +ENI
Sbjct: 66 KTISFEIASSLLFRRQDENDVRQAAELGIEPIDLVVVNLYPFHATLQ-KQAGFEECIENI 124
Query: 412 DIGXVTLLRA 441
DIG TLLRA
Sbjct: 125 DIGGPTLLRA 134
>UniRef50_A7HM64 Cluster: IMP cyclohydrolase; n=1; Fervidobacterium
nodosum Rt17-B1|Rep: IMP cyclohydrolase -
Fervidobacterium nodosum Rt17-B1
Length = 429
Score = 67.7 bits (158), Expect = 3e-10
Identities = 53/136 (38%), Positives = 70/136 (51%), Gaps = 4/136 (2%)
Frame = +1
Query: 46 NGKLALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASER---XPHSSRCVGHHESTG 216
N K AL+SVSDK GL+ AK+L + G+++I++ GTA S+ S G E G
Sbjct: 2 NIKRALISVSDKAGLVEFAKNLVDRGVEIISTGGTAKLLSDAGIPVKQVSDVTGFPEILG 61
Query: 217 DARRSGENFTSSGHAGILARLSD-SDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVA 393
++ GILA L D S +D++ E I +VV NLYPF V
Sbjct: 62 GRVKT---LHPKIFGGILADLGDKSHVKDLRDNFIEPIDLVVVNLYPF-DEVQKKTRDED 117
Query: 394 DAVENIDIGXVTLLRA 441
+ENIDIG V LLRA
Sbjct: 118 VLIENIDIGGVALLRA 133
Score = 46.8 bits (106), Expect = 6e-04
Identities = 20/32 (62%), Positives = 26/32 (81%)
Frame = +2
Query: 155 RXLRNAGLTVQDVSDITRAPEMLGGRVKTLHP 250
+ L +AG+ V+ VSD+T PE+LGGRVKTLHP
Sbjct: 38 KLLSDAGIPVKQVSDVTGFPEILGGRVKTLHP 69
Score = 34.3 bits (75), Expect = 3.4
Identities = 14/21 (66%), Positives = 15/21 (71%)
Frame = +3
Query: 444 AKXHDRVTVVCXPADYDAVVK 506
AK H V VVC PADYD V+K
Sbjct: 135 AKNHRNVVVVCDPADYDKVIK 155
>UniRef50_UPI00015BCE7E Cluster: UPI00015BCE7E related cluster; n=1;
unknown|Rep: UPI00015BCE7E UniRef100 entry - unknown
Length = 506
Score = 66.9 bits (156), Expect = 5e-10
Identities = 49/132 (37%), Positives = 66/132 (50%), Gaps = 4/132 (3%)
Frame = +1
Query: 58 ALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASERXPHS---SRCVGHHESTGDARR 228
AL+SV DKTG+L LAK L G ++++S GT T + S G E G +
Sbjct: 3 ALISVYDKTGILELAKELLNQGYEILSSGGTYTYLKNAGVDAIEVSEVTGFREILGGRVK 62
Query: 229 SGENFTSSGHAGILARLS-DSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVE 405
+ + H GIL R + D E++K E I +VV NLYPF + + VE
Sbjct: 63 T---LHPAIHGGILFREDVEKDLEEIKENSIEPIDIVVVNLYPFEKKMKELK-DIDALVE 118
Query: 406 NIDIGXVTLLRA 441
IDIG TL+RA
Sbjct: 119 FIDIGGPTLVRA 130
Score = 43.2 bits (97), Expect = 0.007
Identities = 19/31 (61%), Positives = 25/31 (80%)
Frame = +2
Query: 161 LRNAGLTVQDVSDITRAPEMLGGRVKTLHPA 253
L+NAG+ +VS++T E+LGGRVKTLHPA
Sbjct: 37 LKNAGVDAIEVSEVTGFREILGGRVKTLHPA 67
>UniRef50_Q9PC10 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=214; cellular organisms|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Xylella fastidiosa
Length = 527
Score = 66.1 bits (154), Expect = 9e-10
Identities = 47/131 (35%), Positives = 68/131 (51%), Gaps = 3/131 (2%)
Frame = +1
Query: 58 ALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASER---XPHSSRCVGHHESTGDARR 228
ALLSVSDKTGL+ LA++L ++L+++ GTAT E + G E D R
Sbjct: 11 ALLSVSDKTGLVELARALLAYNIELLSTGGTATIIREAGLPVQDVADLTGFPEMM-DGR- 68
Query: 229 SGENFTSSGHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVEN 408
+ H G+L R + D M + I +++ NLYPF + T+ADAV+
Sbjct: 69 -VKTLHPMVHGGLLGR-AGIDDAVMAKHGIAPIDLLILNLYPFEQITAKKDCTLADAVDT 126
Query: 409 IDIGXVTLLRA 441
IDIG +LR+
Sbjct: 127 IDIGGPAMLRS 137
Score = 48.8 bits (111), Expect = 1e-04
Identities = 21/30 (70%), Positives = 25/30 (83%)
Frame = +2
Query: 161 LRNAGLTVQDVSDITRAPEMLGGRVKTLHP 250
+R AGL VQDV+D+T PEM+ GRVKTLHP
Sbjct: 45 IREAGLPVQDVADLTGFPEMMDGRVKTLHP 74
>UniRef50_Q1V178 Cluster: Bifunctional purine biosynthesis protein;
n=2; Candidatus Pelagibacter ubique|Rep: Bifunctional
purine biosynthesis protein - Candidatus Pelagibacter
ubique HTCC1002
Length = 518
Score = 65.3 bits (152), Expect = 2e-09
Identities = 46/134 (34%), Positives = 72/134 (53%), Gaps = 4/134 (2%)
Frame = +1
Query: 52 KLALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASERXPHSSRCVGHHESTGDARRS 231
K AL+SVSDK L SL + L++ ++LI+S GT E +C E TG
Sbjct: 12 KKALISVSDKKDLGSLLRVLAKYKIELISSGGTF---KEIKKLKFKCQEVSEYTGSPEIL 68
Query: 232 G---ENFTSSGHAGILARLSD-SDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADA 399
G + HAGIL++ +D S +++K +Y+ I +V+ N YPF ++ +
Sbjct: 69 GGRVKTLHPKIHAGILSKRNDKSHTKELKANQYDEIDLVIVNFYPFEKTLDQT-TNHSKI 127
Query: 400 VENIDIGXVTLLRA 441
+ENID+G T++RA
Sbjct: 128 IENIDVGGPTMVRA 141
Score = 39.1 bits (87), Expect = 0.12
Identities = 16/22 (72%), Positives = 20/22 (90%)
Frame = +2
Query: 185 QDVSDITRAPEMLGGRVKTLHP 250
Q+VS+ T +PE+LGGRVKTLHP
Sbjct: 56 QEVSEYTGSPEILGGRVKTLHP 77
>UniRef50_Q8CXK7 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=34; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Oceanobacillus iheyensis
Length = 510
Score = 65.3 bits (152), Expect = 2e-09
Identities = 44/134 (32%), Positives = 66/134 (49%), Gaps = 4/134 (2%)
Frame = +1
Query: 52 KLALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASER---XPHSSRCVGHHESTGDA 222
K AL+SVSDKT ++ AK L E G +++++ GT +E G E D
Sbjct: 3 KRALISVSDKTNIIEFAKGLKESGFEILSTGGTLRSIAEAGIDVTPVDEVTGFPEML-DG 61
Query: 223 RRSGENFTSSGHAGILARLSDSDQ-EDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADA 399
R + H G+L + S+ + M+ I +V NLYPF +V V+ D
Sbjct: 62 R--VKTLHPMIHGGLLGKRSNHEHLSQMEEHGIRSIDLVAVNLYPFKETVQKPDVSHQDI 119
Query: 400 VENIDIGXVTLLRA 441
+ENIDIG ++LR+
Sbjct: 120 IENIDIGGPSMLRS 133
Score = 41.1 bits (92), Expect = 0.030
Identities = 18/32 (56%), Positives = 22/32 (68%)
Frame = +2
Query: 155 RXLRNAGLTVQDVSDITRAPEMLGGRVKTLHP 250
R + AG+ V V ++T PEML GRVKTLHP
Sbjct: 37 RSIAEAGIDVTPVDEVTGFPEMLDGRVKTLHP 68
>UniRef50_Q7X311 Cluster: Putative AICAR transformylase; n=1;
uncultured Acidobacteria bacterium|Rep: Putative AICAR
transformylase - uncultured Acidobacteria bacterium
Length = 571
Score = 64.9 bits (151), Expect = 2e-09
Identities = 44/132 (33%), Positives = 68/132 (51%), Gaps = 4/132 (3%)
Frame = +1
Query: 58 ALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASE---RXPHSSRCVGHHESTGDARR 228
AL+SVSDKTG++ A L ++++++ GTA E S G E D R
Sbjct: 15 ALISVSDKTGIVDFASELRAFDIEIVSTGGTAKTLREAGIEVRDVSDVTGFPEMM-DGRV 73
Query: 229 SGENFTSSGHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVE 405
+ H G+L R S S + M+ E I +VV +LYPF ++ V++A+A+E
Sbjct: 74 --KTLHPKIHGGLLGVRDSPSHESSMREHGIEPIDMVVIDLYPFERTIKGAAVSLAEAIE 131
Query: 406 NIDIGXVTLLRA 441
IDIG ++R+
Sbjct: 132 QIDIGGPAMIRS 143
Score = 49.2 bits (112), Expect = 1e-04
Identities = 21/32 (65%), Positives = 26/32 (81%)
Frame = +2
Query: 155 RXLRNAGLTVQDVSDITRAPEMLGGRVKTLHP 250
+ LR AG+ V+DVSD+T PEM+ GRVKTLHP
Sbjct: 47 KTLREAGIEVRDVSDVTGFPEMMDGRVKTLHP 78
>UniRef50_Q8D244 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=2; Gammaproteobacteria|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Wigglesworthia glossinidia
brevipalpis
Length = 529
Score = 64.9 bits (151), Expect = 2e-09
Identities = 40/130 (30%), Positives = 66/130 (50%)
Frame = +1
Query: 52 KLALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASERXPHSSRCVGHHESTGDARRS 231
+ AL+SVSDKTG+ SLAK+L + ++LI + GT E+ S+ +
Sbjct: 9 RCALISVSDKTGIFSLAKNLIKHKVKLITTSGTYKYLLEKGIFSTSVSEYINHPEIINGR 68
Query: 232 GENFTSSGHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVENI 411
+ H GIL+ ++ + + K + I +V+ N YPF V + + + ++NI
Sbjct: 69 VKTLHPKIHGGILS--NNKNINENKNLNIKKIDMVITNFYPFKKKVKKENIKIENIIDNI 126
Query: 412 DIGXVTLLRA 441
DIG V L R+
Sbjct: 127 DIGGVALARS 136
>UniRef50_Q9FPL3 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=14;
Viridiplantae|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Nicotiana tabacum
(Common tobacco)
Length = 612
Score = 64.5 bits (150), Expect = 3e-09
Identities = 43/139 (30%), Positives = 66/139 (47%), Gaps = 2/139 (1%)
Frame = +1
Query: 31 QNMASNGKLALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASERXPHSSRCVGHHES 210
++ S K AL+S+SDKT L L L E G ++++ GT++ ++
Sbjct: 82 KSSTSGRKQALISLSDKTDLAKLGNGLQELGYTIVSTGGTSSALEGAGVSVTKVEELTRF 141
Query: 211 TGDARRSGENFTSSGHAGILARL-SDSDQEDMKRQKYEMISVVVCNLYPFVXSV-SXXXV 384
+ S H GILAR + E +++ + VVV NLYPF V S +
Sbjct: 142 PEMLDGRVKTLHPSVHGGILARRDQEHHMEALEKHEIGTFDVVVVNLYPFYAKVSSSSGI 201
Query: 385 TVADAVENIDIGXVTLLRA 441
+ D +ENIDIG ++RA
Sbjct: 202 SFEDGIENIDIGGPAMIRA 220
Score = 44.0 bits (99), Expect = 0.004
Identities = 19/31 (61%), Positives = 24/31 (77%)
Frame = +2
Query: 161 LRNAGLTVQDVSDITRAPEMLGGRVKTLHPA 253
L AG++V V ++TR PEML GRVKTLHP+
Sbjct: 125 LEGAGVSVTKVEELTRFPEMLDGRVKTLHPS 155
>UniRef50_Q9F1T4 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=57; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Streptococcus suis
Length = 515
Score = 63.7 bits (148), Expect = 5e-09
Identities = 44/134 (32%), Positives = 69/134 (51%), Gaps = 4/134 (2%)
Frame = +1
Query: 52 KLALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASERXPHSSRCVGHHESTGDARRS 231
K AL+SVSDK G++ A+ L++ G ++I++ GT + + + + TG
Sbjct: 3 KRALISVSDKNGIVEFAQELTKFGWEIISTGGTKVALDQAGVTT---IAIDDVTGFPEMM 59
Query: 232 G---ENFTSSGHAGILARLS-DSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADA 399
+ H G+LAR DS + + +I +VV NLYPF ++ VT A
Sbjct: 60 DGRVKTLHPKIHGGLLARRDLDSHLQAANDHEIGLIDLVVVNLYPFKETILRPDVTYDLA 119
Query: 400 VENIDIGXVTLLRA 441
VENIDIG ++LR+
Sbjct: 120 VENIDIGGPSMLRS 133
>UniRef50_A6G003 Cluster: Bifunctional
phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=1; Plesiocystis
pacifica SIR-1|Rep: Bifunctional
phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Plesiocystis
pacifica SIR-1
Length = 543
Score = 61.7 bits (143), Expect = 2e-08
Identities = 45/131 (34%), Positives = 70/131 (53%), Gaps = 3/131 (2%)
Frame = +1
Query: 58 ALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASE---RXPHSSRCVGHHESTGDARR 228
AL+SVSDK+ L LA+ L ++++++ GT SE S G E D R
Sbjct: 17 ALVSVSDKSKLDVLAEILIAHKVEVLSTGGTYRALSELGVAVVKVSEFTGAPEIL-DGR- 74
Query: 229 SGENFTSSGHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVEN 408
+ H GILA +++ Q +++ I +V+ NLYPF +++ + ADA+EN
Sbjct: 75 -VKTLHPKIHGGILALPTEAHQRELELHDIAPIDLVIVNLYPFRETIAKPGCSFADAIEN 133
Query: 409 IDIGXVTLLRA 441
IDIG T++RA
Sbjct: 134 IDIGGPTMVRA 144
Score = 41.1 bits (92), Expect = 0.030
Identities = 23/44 (52%), Positives = 27/44 (61%)
Frame = +2
Query: 155 RXLRNAGLTVQDVSDITRAPEMLGGRVKTLHPADMLGS*LDYPT 286
R L G+ V VS+ T APE+L GRVKTLHP + G L PT
Sbjct: 49 RALSELGVAVVKVSEFTGAPEILDGRVKTLHP-KIHGGILALPT 91
>UniRef50_A7BET6 Cluster: Putative uncharacterized protein; n=1;
Actinomyces odontolyticus ATCC 17982|Rep: Putative
uncharacterized protein - Actinomyces odontolyticus ATCC
17982
Length = 614
Score = 60.9 bits (141), Expect = 3e-08
Identities = 48/149 (32%), Positives = 76/149 (51%), Gaps = 4/149 (2%)
Frame = +1
Query: 52 KLALLSVSDKTGLLSLAKSLSECGLQLIASXGTATX---ASERXPHSSRCVGHHESTGDA 222
K AL+SV DKTGL LA++L E G++++++ TA A G E
Sbjct: 17 KRALISVYDKTGLEDLARALGEAGVEIVSTGSTAARIAAAGVAVTPVDDVTGFPEVLEGR 76
Query: 223 RRSGENFTSSGHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADA 399
++ F H+GILA + + +E + + + +VVCNLYPF +V+ + +
Sbjct: 77 VKTLHPFI---HSGILADQRKAAHREQIAQLGIQAFDLVVCNLYPFQDTVA-SGASFDEC 132
Query: 400 VENIDIGXVTLLRAQPRXTTGSPSSVTRP 486
VE IDIG +++RA + S + VT P
Sbjct: 133 VEQIDIGGPSMVRAAAK-NHPSVAVVTSP 160
Score = 38.7 bits (86), Expect = 0.16
Identities = 17/27 (62%), Positives = 20/27 (74%)
Frame = +2
Query: 170 AGLTVQDVSDITRAPEMLGGRVKTLHP 250
AG+ V V D+T PE+L GRVKTLHP
Sbjct: 56 AGVAVTPVDDVTGFPEVLEGRVKTLHP 82
>UniRef50_O67775 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=9; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Aquifex aeolicus
Length = 506
Score = 60.1 bits (139), Expect = 6e-08
Identities = 45/132 (34%), Positives = 68/132 (51%), Gaps = 4/132 (3%)
Frame = +1
Query: 58 ALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASER---XPHSSRCVGHHESTGDARR 228
A++SV K G+ LAK+L E G +++++ GTA E+ S G E +
Sbjct: 3 AIISVYRKEGIDKLAKALQELGYEIVSTGGTAKYLREKGISVKEVSEITGFPEILEGRVK 62
Query: 229 SGENFTSSGHAGILAR-LSDSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVE 405
+ H GIL R + D+E++++ + I VVV NLYPF + +T D +E
Sbjct: 63 TLHPVV---HGGILFRDWVEKDKEEIEKHGIKPIDVVVVNLYPFEEKLK-EGLTDKDLME 118
Query: 406 NIDIGXVTLLRA 441
IDIG TL+RA
Sbjct: 119 FIDIGGPTLIRA 130
Score = 44.0 bits (99), Expect = 0.004
Identities = 19/32 (59%), Positives = 26/32 (81%)
Frame = +2
Query: 155 RXLRNAGLTVQDVSDITRAPEMLGGRVKTLHP 250
+ LR G++V++VS+IT PE+L GRVKTLHP
Sbjct: 35 KYLREKGISVKEVSEITGFPEILEGRVKTLHP 66
>UniRef50_A0JTW4 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=2;
Arthrobacter|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Arthrobacter sp.
(strain FB24)
Length = 559
Score = 59.7 bits (138), Expect = 8e-08
Identities = 48/132 (36%), Positives = 65/132 (49%), Gaps = 4/132 (3%)
Frame = +1
Query: 58 ALLSVSDKTGLLSLAKSLSECGLQLIASXGTA-TXASERXP--HSSRCVGHHESTGDARR 228
AL+SV DKTGL LAK L E G++++++ TA A+ P G E D R
Sbjct: 14 ALISVYDKTGLEELAKGLHEAGVKIVSTGSTAKKIAAAGIPVQEVEEVTGSPEML-DGR- 71
Query: 229 SGENFTSSGHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVE 405
+ H GILA R + E + + E +VV NLYPFV +V D VE
Sbjct: 72 -VKTLHPRVHGGILADRRVPAHMETLAGMEIEAFDLVVVNLYPFVETVK-SGAAQDDVVE 129
Query: 406 NIDIGXVTLLRA 441
IDIG ++R+
Sbjct: 130 QIDIGGPAMVRS 141
Score = 44.0 bits (99), Expect = 0.004
Identities = 18/27 (66%), Positives = 23/27 (85%)
Frame = +2
Query: 170 AGLTVQDVSDITRAPEMLGGRVKTLHP 250
AG+ VQ+V ++T +PEML GRVKTLHP
Sbjct: 51 AGIPVQEVEEVTGSPEMLDGRVKTLHP 77
>UniRef50_Q9RW01 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=3; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Deinococcus radiodurans
Length = 510
Score = 59.3 bits (137), Expect = 1e-07
Identities = 46/133 (34%), Positives = 66/133 (49%), Gaps = 3/133 (2%)
Frame = +1
Query: 52 KLALLSVSDKTGLLSLAKSLSECGLQLIASXGT-ATXASERXP--HSSRCVGHHESTGDA 222
K AL+SVSDKTG++ A L + G +L+++ GT AT + P S G E D
Sbjct: 3 KRALISVSDKTGVVEFAAQLQQRGWELLSTGGTFATLSGAGIPVRQVSDVTGFPEML-DG 61
Query: 223 RRSGENFTSSGHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAV 402
R + + H GILAR + Q I +V NLYPF +V+ + +
Sbjct: 62 R--VKTLHPAIHGGILARREAGHLGQLAAQDIGTIDLVCVNLYPFRETVA-RGAPDPEVI 118
Query: 403 ENIDIGXVTLLRA 441
ENIDIG ++R+
Sbjct: 119 ENIDIGGPAMIRS 131
Score = 46.4 bits (105), Expect = 8e-04
Identities = 21/31 (67%), Positives = 24/31 (77%)
Frame = +2
Query: 161 LRNAGLTVQDVSDITRAPEMLGGRVKTLHPA 253
L AG+ V+ VSD+T PEML GRVKTLHPA
Sbjct: 39 LSGAGIPVRQVSDVTGFPEMLDGRVKTLHPA 69
>UniRef50_A2SS05 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=3;
Methanomicrobiales|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase -
Methanocorpusculum labreanum (strain ATCC 43576 / DSM
4855 / Z)
Length = 497
Score = 58.0 bits (134), Expect = 2e-07
Identities = 41/129 (31%), Positives = 63/129 (48%)
Frame = +1
Query: 55 LALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASERXPHSSRCVGHHESTGDARRSG 234
LALLSV DKTG+L LA++L + +++S GTA E + + +
Sbjct: 3 LALLSVWDKTGILDLARALVAKNIGILSSGGTAKALREAGIPAKDVSEYTQFPEMMDGRV 62
Query: 235 ENFTSSGHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVENID 414
+ H G+L R D + MK E I ++ NLYPF +S + + + +E ID
Sbjct: 63 KTLHPKVHGGLLGR-RGIDDDVMKAHFIEPIDILCVNLYPF-EEMSKKNLPLEELIEFID 120
Query: 415 IGXVTLLRA 441
IG ++RA
Sbjct: 121 IGGPAMIRA 129
Score = 45.6 bits (103), Expect = 0.001
Identities = 19/32 (59%), Positives = 25/32 (78%)
Frame = +2
Query: 155 RXLRNAGLTVQDVSDITRAPEMLGGRVKTLHP 250
+ LR AG+ +DVS+ T+ PEM+ GRVKTLHP
Sbjct: 36 KALREAGIPAKDVSEYTQFPEMMDGRVKTLHP 67
>UniRef50_A7DF55 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=3;
Alphaproteobacteria|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Methylobacterium
extorquens PA1
Length = 581
Score = 57.2 bits (132), Expect = 4e-07
Identities = 46/132 (34%), Positives = 65/132 (49%), Gaps = 4/132 (3%)
Frame = +1
Query: 58 ALLSVSDKTGLLSLAKSLSECGLQLIASXGT---ATXASERXPHSSRCVGHHESTGDARR 228
ALLSVSDKTGL A +LS+ G++L+++ GT T A S E D R
Sbjct: 60 ALLSVSDKTGLTDFAAALSQRGVELVSTGGTHRALTEAGLAVREVSELTRFPEMM-DGR- 117
Query: 229 SGENFTSSGHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVE 405
+ + H G+LA R + Q + I ++V NLYPF ++ D VE
Sbjct: 118 -VKTLHPAVHGGLLAVRDNPEHQAALAAHGIGAIDLLVVNLYPFEETLKAGK-AYDDCVE 175
Query: 406 NIDIGXVTLLRA 441
NID+G ++RA
Sbjct: 176 NIDVGGPAMIRA 187
Score = 50.0 bits (114), Expect = 6e-05
Identities = 22/33 (66%), Positives = 27/33 (81%)
Frame = +2
Query: 155 RXLRNAGLTVQDVSDITRAPEMLGGRVKTLHPA 253
R L AGL V++VS++TR PEM+ GRVKTLHPA
Sbjct: 92 RALTEAGLAVREVSELTRFPEMMDGRVKTLHPA 124
>UniRef50_Q6L122 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=4; Thermoplasmatales|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Picrophilus torridus
Length = 494
Score = 57.2 bits (132), Expect = 4e-07
Identities = 44/130 (33%), Positives = 68/130 (52%), Gaps = 3/130 (2%)
Frame = +1
Query: 61 LLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASERXPHSSRCVGHHESTG-DARRSGE 237
L+SVSD +GL L + L+ + A+ GT S+ + R + TG D +G
Sbjct: 4 LVSVSDTSGLTDLLRHLNG---DVYATPGTFKFLSDSGIKAKRI---SDITGFDDLLNGR 57
Query: 238 NFT--SSGHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVENI 411
T + +GIL+R + + D+KR Y +V+CNLY F S ++ D +ENI
Sbjct: 58 VKTLHPAVFSGILSRRDEQSEADLKRYNYFDFDIVICNLYNF---ESYIDKSIEDMIENI 114
Query: 412 DIGXVTLLRA 441
DIG ++L+RA
Sbjct: 115 DIGGLSLIRA 124
Score = 38.7 bits (86), Expect = 0.16
Identities = 17/37 (45%), Positives = 25/37 (67%)
Frame = +2
Query: 155 RXLRNAGLTVQDVSDITRAPEMLGGRVKTLHPADMLG 265
+ L ++G+ + +SDIT ++L GRVKTLHPA G
Sbjct: 32 KFLSDSGIKAKRISDITGFDDLLNGRVKTLHPAVFSG 68
>UniRef50_Q8XMK2 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=14; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Clostridium perfringens
Length = 501
Score = 57.2 bits (132), Expect = 4e-07
Identities = 44/131 (33%), Positives = 63/131 (48%), Gaps = 1/131 (0%)
Frame = +1
Query: 52 KLALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASERXPHSSRCVGHHESTGDARRS 231
K AL+SV DK G+L LAK L + +++I+S GT E +
Sbjct: 3 KRALISVFDKDGVLELAKFLRDRDVEIISSGGTYKYLKENNIEVKEISEITDFPEMLDGR 62
Query: 232 GENFTSSGHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVEN 408
+ HAGILA R + + ++ ++ I VV NLYPF V ++ + VE
Sbjct: 63 VKTLHPLVHAGILAIRDNKEHMKTLEEREINTIDYVVVNLYPFFEKV-REDLSFEEKVEF 121
Query: 409 IDIGXVTLLRA 441
IDIG T+LRA
Sbjct: 122 IDIGGPTMLRA 132
Score = 40.7 bits (91), Expect = 0.039
Identities = 17/32 (53%), Positives = 24/32 (75%)
Frame = +2
Query: 155 RXLRNAGLTVQDVSDITRAPEMLGGRVKTLHP 250
+ L+ + V+++S+IT PEML GRVKTLHP
Sbjct: 37 KYLKENNIEVKEISEITDFPEMLDGRVKTLHP 68
>UniRef50_A7I7L2 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=1; Candidatus
Methanoregula boonei 6A8|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Methanoregula
boonei (strain 6A8)
Length = 525
Score = 55.6 bits (128), Expect = 1e-06
Identities = 45/133 (33%), Positives = 66/133 (49%), Gaps = 3/133 (2%)
Frame = +1
Query: 52 KLALLSVSDKTGLLSLAKSLSECGLQLIASXGTAT-XASERXPHS--SRCVGHHESTGDA 222
K ALLSV DKTG++ LA++L + +++S GT T A P + SR G E D
Sbjct: 32 KWALLSVWDKTGIVDLAQALIQHNFSIMSSGGTGTALAGAGIPFTEVSRYTGFPEMM-DG 90
Query: 223 RRSGENFTSSGHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAV 402
R + H G+L R D M + I ++V NLYPF +S + + +
Sbjct: 91 R--VKTLHPKVHGGLLGR-RQIDDAIMAKYGINRIGLLVVNLYPF-ERMSRESLPLEKLI 146
Query: 403 ENIDIGXVTLLRA 441
E ID+G ++RA
Sbjct: 147 EYIDVGGPAMIRA 159
Score = 37.1 bits (82), Expect = 0.49
Identities = 17/30 (56%), Positives = 20/30 (66%)
Frame = +2
Query: 161 LRNAGLTVQDVSDITRAPEMLGGRVKTLHP 250
L AG+ +VS T PEM+ GRVKTLHP
Sbjct: 68 LAGAGIPFTEVSRYTGFPEMMDGRVKTLHP 97
>UniRef50_Q89B23 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=2; Buchnera aphidicola (Baizongia
pistaciae)|Rep: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Buchnera aphidicola subsp.
Baizongia pistaciae
Length = 529
Score = 54.0 bits (124), Expect = 4e-06
Identities = 33/130 (25%), Positives = 65/130 (50%)
Frame = +1
Query: 52 KLALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASERXPHSSRCVGHHESTGDARRS 231
K L+SVSD + ++ +KSL ++L A+ GTA + +++ +
Sbjct: 8 KNVLISVSDTSNIIEFSKSLISKNIKLFATKGTANFLKKNNIYATDITNYTNFPEIMNGR 67
Query: 232 GENFTSSGHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVENI 411
+ +A ILA+ D++ +++ ++ +VV N YPF + + + + D +E+I
Sbjct: 68 IKTLHHKIYASILAQ-PKHDKKTIEKYNIILMDIVVINFYPFEEASNNTNLHLNDIIEHI 126
Query: 412 DIGXVTLLRA 441
DIG ++RA
Sbjct: 127 DIGGPAIVRA 136
>UniRef50_Q83GZ1 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=2; Tropheryma whipplei|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Tropheryma whipplei (strain Twist)
(Whipple's bacillus)
Length = 542
Score = 53.6 bits (123), Expect = 5e-06
Identities = 41/138 (29%), Positives = 64/138 (46%), Gaps = 2/138 (1%)
Frame = +1
Query: 52 KLALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASERXPHSSRCVGHHESTGDARRS 231
K AL+SVSDK+GL LA++L+ ++++++ TA R V G+
Sbjct: 8 KRALISVSDKSGLADLAEALAAHSVKIVSTGSTAEFI-RGVSIPVRDVSEVTGVGELLDG 66
Query: 232 G-ENFTSSGHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVE 405
+ HA ILA S + +++ + +VV NLYPF +D +E
Sbjct: 67 RVKTLHPKIHAPILADTTSQMHRAQLQQLGVDAFDLVVVNLYPFFEISKNSEAEFSDVIE 126
Query: 406 NIDIGXVTLLRAQPRXTT 459
IDIG L+RA + T
Sbjct: 127 QIDIGGSALIRAAAKNHT 144
Score = 39.1 bits (87), Expect = 0.12
Identities = 16/30 (53%), Positives = 22/30 (73%)
Frame = +2
Query: 161 LRNAGLTVQDVSDITRAPEMLGGRVKTLHP 250
+R + V+DVS++T E+L GRVKTLHP
Sbjct: 44 IRGVSIPVRDVSEVTGVGELLDGRVKTLHP 73
>UniRef50_A4MAE3 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=1; Petrotoga mobilis SJ95|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Petrotoga mobilis SJ95
Length = 489
Score = 52.4 bits (120), Expect = 1e-05
Identities = 44/136 (32%), Positives = 67/136 (49%), Gaps = 4/136 (2%)
Frame = +1
Query: 46 NGKLALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASERXPHSSRC---VGHHESTG 216
N K A++SV DKT L LA L G+++I + GT E+ + + +G E G
Sbjct: 2 NIKRAIISVYDKTNLEDLASFLYRNGVEIICTEGTNKYLQEKGIPTVKMADYIGFPEILG 61
Query: 217 DARRSGENFTSSGHAGILARLSDSD-QEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVA 393
+S + + G ILA+ +D +EDM + I +VV N +P ++
Sbjct: 62 GRVKSIDPKLAGG---ILAKSNDKKHEEDMINYNIKRIDMVVGN-FPTFEEIAKKTKNEE 117
Query: 394 DAVENIDIGXVTLLRA 441
+ENIDIG +LLRA
Sbjct: 118 TLLENIDIGGYSLLRA 133
>UniRef50_Q9PNY2 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=21; Epsilonproteobacteria|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Campylobacter jejuni
Length = 510
Score = 52.4 bits (120), Expect = 1e-05
Identities = 37/129 (28%), Positives = 57/129 (44%), Gaps = 1/129 (0%)
Frame = +1
Query: 58 ALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASERXPHSSRCVGHHESTGDARRSGE 237
ALLSVSDK G++ K L G +++++ GT E +S +
Sbjct: 3 ALLSVSDKEGIVEFGKELENLGFEILSTGGTFKLLKENGIKVIEVSDFTKSPELFEGRVK 62
Query: 238 NFTSSGHAGILARLSDSDQ-EDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVENID 414
H GIL + SD + + K + I +V NLYPF + + +ENID
Sbjct: 63 TLHPKIHGGILHKRSDENHIKQAKENEILGIDLVCVNLYPF-KKTTIMSDDFDEIIENID 121
Query: 415 IGXVTLLRA 441
IG ++R+
Sbjct: 122 IGGPAMIRS 130
Score = 41.5 bits (93), Expect = 0.023
Identities = 17/32 (53%), Positives = 24/32 (75%)
Frame = +2
Query: 155 RXLRNAGLTVQDVSDITRAPEMLGGRVKTLHP 250
+ L+ G+ V +VSD T++PE+ GRVKTLHP
Sbjct: 35 KLLKENGIKVIEVSDFTKSPELFEGRVKTLHP 66
>UniRef50_A1IEQ8 Cluster: IMP cyclohydrolase; n=1; Candidatus
Desulfococcus oleovorans Hxd3|Rep: IMP cyclohydrolase -
Candidatus Desulfococcus oleovorans Hxd3
Length = 225
Score = 51.6 bits (118), Expect = 2e-05
Identities = 44/138 (31%), Positives = 63/138 (45%), Gaps = 8/138 (5%)
Frame = +1
Query: 61 LLSVSDKTGLLSLAKSLSECG--LQLIASXGTATXASERXPHSSRCVGHHES--TGDARR 228
L+SVSDKTGL L + + ++ GT E +++ V S TG
Sbjct: 19 LISVSDKTGLEEFVTRLVRINPDVHIFSTGGTYQKIYEIFGSAAKSVLTQVSDYTGQPET 78
Query: 229 SG---ENFTSSGHAGILARL-SDSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVAD 396
G + + G+L ++S DMKR I +VV NLYPF +V+ VT
Sbjct: 79 QGGLVKTLDFKIYLGLLTETYNESHARDMKRTGAVAIDMVVVNLYPFSQTVARPDVTPEQ 138
Query: 397 AVENIDIGXVTLLRAQPR 450
A NIDIG ++RA +
Sbjct: 139 ARGNIDIGGPCMVRASAK 156
>UniRef50_Q7VRP9 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase, IMP cyclohydrolase and MGS-like
domain; n=2; Candidatus Blochmannia|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase, IMP cyclohydrolase and MGS-like
domain - Blochmannia floridanus
Length = 549
Score = 50.8 bits (116), Expect = 4e-05
Identities = 36/128 (28%), Positives = 61/128 (47%)
Frame = +1
Query: 58 ALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASERXPHSSRCVGHHESTGDARRSGE 237
AL+SV DK+ LL +KSLS G++L+++ GTA + ++ + +
Sbjct: 10 ALISVFDKSNLLHFSKSLSHLGIKLLSTEGTALILTNAGLTVNKISDYTNFPEIMNGQVK 69
Query: 238 NFTSSGHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVENIDI 417
AGIL+R + D+ + + + I +V+ N YPF + +E IDI
Sbjct: 70 TLHHKICAGILSR-KNLDESIIHKYGIQPIDMVIVNFYPFHLILQNKQHDSEKILEYIDI 128
Query: 418 GXVTLLRA 441
G ++RA
Sbjct: 129 GGPNMVRA 136
Score = 41.9 bits (94), Expect = 0.017
Identities = 18/29 (62%), Positives = 22/29 (75%)
Frame = +2
Query: 161 LRNAGLTVQDVSDITRAPEMLGGRVKTLH 247
L NAGLTV +SD T PE++ G+VKTLH
Sbjct: 44 LTNAGLTVNKISDYTNFPEIMNGQVKTLH 72
>UniRef50_Q316G8 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=4; Desulfovibrionaceae|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Desulfovibrio desulfuricans (strain
G20)
Length = 252
Score = 50.0 bits (114), Expect = 6e-05
Identities = 40/132 (30%), Positives = 64/132 (48%), Gaps = 4/132 (3%)
Frame = +1
Query: 58 ALLSVSDKTGLLSLAKSLSECGLQLIASXG---TATXASERXPHSSRCVGHHESTGDARR 228
ALLSV+DK+GL+ A L++ G++L+++ G T T A S+ G E G +
Sbjct: 62 ALLSVTDKSGLVEFATFLTQNGVELVSTGGTQRTLTEAGLDVTPVSKVTGFPEIMGGRVK 121
Query: 229 SGENFTSSGHAGILARLSDSDQ-EDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVE 405
+ H GILA + + +K ++ NLY F + + + + AVE
Sbjct: 122 T---LHPHIHGGILADKDNPEHLATLKELGIRTFDLICVNLYNFADAAA-RGLDLRGAVE 177
Query: 406 NIDIGXVTLLRA 441
+DIG +LRA
Sbjct: 178 EVDIGGPCMLRA 189
Score = 43.6 bits (98), Expect = 0.006
Identities = 20/32 (62%), Positives = 23/32 (71%)
Frame = +2
Query: 155 RXLRNAGLTVQDVSDITRAPEMLGGRVKTLHP 250
R L AGL V VS +T PE++GGRVKTLHP
Sbjct: 94 RTLTEAGLDVTPVSKVTGFPEIMGGRVKTLHP 125
>UniRef50_Q8G6B1 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=89; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Bifidobacterium longum
Length = 545
Score = 48.8 bits (111), Expect = 1e-04
Identities = 37/131 (28%), Positives = 66/131 (50%), Gaps = 4/131 (3%)
Frame = +1
Query: 58 ALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASE---RXPHSSRCVGHHESTGDARR 228
AL+SV K G+ LA++ + G +++++ TA +E + S G E +
Sbjct: 11 ALVSVFHKEGIEVLAEAFVKAGTEVVSTGSTAKKLAELGVKVTEVSDVTGFPECLDGRVK 70
Query: 229 SGENFTSSGHAGILARLSDSDQ-EDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVE 405
+ + HAGILA +++ + + ++ + +VV NLYPF +V AD +E
Sbjct: 71 TLHPYI---HAGILADMTNPEHAKQLEEFGIKPFDLVVVNLYPFADTV-RSGANEADTIE 126
Query: 406 NIDIGXVTLLR 438
IDIG +++R
Sbjct: 127 KIDIGGPSMVR 137
Score = 40.3 bits (90), Expect = 0.052
Identities = 18/32 (56%), Positives = 22/32 (68%)
Frame = +2
Query: 155 RXLRNAGLTVQDVSDITRAPEMLGGRVKTLHP 250
+ L G+ V +VSD+T PE L GRVKTLHP
Sbjct: 43 KKLAELGVKVTEVSDVTGFPECLDGRVKTLHP 74
>UniRef50_Q7MUT5 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=24;
Bacteria|Rep: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Porphyromonas
gingivalis (Bacteroides gingivalis)
Length = 508
Score = 44.8 bits (101), Expect = 0.002
Identities = 38/131 (29%), Positives = 65/131 (49%), Gaps = 4/131 (3%)
Frame = +1
Query: 58 ALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASERXPHSSRCVG---HHESTGDARR 228
AL+SV K GL + L+ G++ +++ GT + ++ R V + S R
Sbjct: 11 ALISVYHKEGLAEILAELNRQGVEFVSTGGTHEFITSLG-YACRAVDDLTRYPSMLGGRV 69
Query: 229 SGENFTSSGHAGILARLS-DSDQEDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVE 405
+ G GILAR +SD ++ +I +V+ +LYPF +V+ + D +E
Sbjct: 70 KTLHPMIFG--GILARRGHESDVREVGEYGLPLIDLVIVDLYPFEATVA-SGASEEDIIE 126
Query: 406 NIDIGXVTLLR 438
IDIG ++L+R
Sbjct: 127 KIDIGGISLIR 137
Score = 40.3 bits (90), Expect = 0.052
Identities = 17/30 (56%), Positives = 21/30 (70%)
Frame = +2
Query: 161 LRNAGLTVQDVSDITRAPEMLGGRVKTLHP 250
+ + G + V D+TR P MLGGRVKTLHP
Sbjct: 45 ITSLGYACRAVDDLTRYPSMLGGRVKTLHP 74
>UniRef50_A1G3C3 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=1; Salinispora arenicola
CNS205|Rep: Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Salinispora arenicola CNS205
Length = 190
Score = 38.3 bits (85), Expect = 0.21
Identities = 30/102 (29%), Positives = 46/102 (45%), Gaps = 3/102 (2%)
Frame = +1
Query: 55 LALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASERXPHSSRCVGHHESTGDARRSG 234
LA+L+VSDK + LA L G ++A+ GT + H + G G
Sbjct: 2 LAVLAVSDKRNIEELATGLLGLGWDVVATEGTRRLLRD---HGVTVGAVSDLAGVPTLLG 58
Query: 235 ---ENFTSSGHAGILARLSDSDQEDMKRQKYEMISVVVCNLY 351
+ T S GILAR +D+ +++R + +V CN Y
Sbjct: 59 GRVKTLTVSLMGGILARDEPADRAEVERHGLTRVHLVCCNYY 100
Score = 38.3 bits (85), Expect = 0.21
Identities = 18/30 (60%), Positives = 22/30 (73%)
Frame = +2
Query: 155 RXLRNAGLTVQDVSDITRAPEMLGGRVKTL 244
R LR+ G+TV VSD+ P +LGGRVKTL
Sbjct: 35 RLLRDHGVTVGAVSDLAGVPTLLGGRVKTL 64
>UniRef50_Q9X0X6 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=4; Thermotogaceae|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Thermotoga maritima
Length = 452
Score = 36.3 bits (80), Expect = 0.85
Identities = 17/37 (45%), Positives = 22/37 (59%)
Frame = +2
Query: 155 RXLRNAGLTVQDVSDITRAPEMLGGRVKTLHPADMLG 265
+ L++ G+ DVS IT +LGG VKTLHP G
Sbjct: 36 KFLKSNGIEANDVSTITGFENLLGGLVKTLHPEIFAG 72
>UniRef50_Q8A155 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=5; Bacteroides|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Bacteroides thetaiotaomicron
Length = 507
Score = 36.3 bits (80), Expect = 0.85
Identities = 15/30 (50%), Positives = 20/30 (66%)
Frame = +2
Query: 161 LRNAGLTVQDVSDITRAPEMLGGRVKTLHP 250
+ + G + V D+T P +LGGRVKTLHP
Sbjct: 44 IESLGYPCKAVEDLTTYPSILGGRVKTLHP 73
>UniRef50_Q3JNS9 Cluster: Putative uncharacterized protein; n=9;
Burkholderia|Rep: Putative uncharacterized protein -
Burkholderia pseudomallei (strain 1710b)
Length = 917
Score = 35.1 bits (77), Expect = 2.0
Identities = 19/34 (55%), Positives = 20/34 (58%)
Frame = -1
Query: 438 AQEGHAADVDVLDRVRXGHXXXRYXXDERVQVTD 337
AQ AADVDVLDRV R DER+QV D
Sbjct: 723 AQHRRAADVDVLDRVGERAVVLRNRLDERIQVHD 756
>UniRef50_A4M1L4 Cluster: Putative uncharacterized protein; n=1;
Geobacter bemidjiensis Bem|Rep: Putative uncharacterized
protein - Geobacter bemidjiensis Bem
Length = 546
Score = 35.1 bits (77), Expect = 2.0
Identities = 17/36 (47%), Positives = 21/36 (58%)
Frame = -1
Query: 438 AQEGHAADVDVLDRVRXGHXXXRYXXDERVQVTDHH 331
A+ G AAD+DVLD + G R ERV+V HH
Sbjct: 412 AEHGRAADIDVLDGILHGAVLFRDGRLERVEVYHHH 447
>UniRef50_A5B3D8 Cluster: DNA-directed RNA polymerase; n=1; Vitis
vinifera|Rep: DNA-directed RNA polymerase - Vitis
vinifera (Grape)
Length = 153
Score = 33.5 bits (73), Expect = 6.0
Identities = 19/51 (37%), Positives = 22/51 (43%), Gaps = 1/51 (1%)
Frame = +1
Query: 256 HAGILARLSDSDQ-EDMKRQKYEMISVVVCNLYPFVXSVSXXXVTVADAVE 405
H GILAR E + VVV NLYPF VS + D +E
Sbjct: 14 HGGILARRDQKHHMEALNEHGIGTFDVVVVNLYPFYDKVSLGGIEFEDEIE 64
>UniRef50_UPI0000382898 Cluster: COG0138: AICAR transformylase/IMP
cyclohydrolase PurH (only IMP cyclohydrolase domain in
Aful); n=1; Magnetospirillum magnetotacticum MS-1|Rep:
COG0138: AICAR transformylase/IMP cyclohydrolase PurH
(only IMP cyclohydrolase domain in Aful) -
Magnetospirillum magnetotacticum MS-1
Length = 50
Score = 33.1 bits (72), Expect = 7.9
Identities = 17/45 (37%), Positives = 24/45 (53%)
Frame = +1
Query: 58 ALLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASERXPHSSRC 192
ALLSVSDKTGL A +L G++L+++ S +C
Sbjct: 4 ALLSVSDKTGLTDFAAALIGQGVELVSTAAPIARXHRAGLRSGKC 48
>UniRef50_A5KA45 Cluster: Putative uncharacterized protein; n=2;
Plasmodium|Rep: Putative uncharacterized protein -
Plasmodium vivax
Length = 4034
Score = 33.1 bits (72), Expect = 7.9
Identities = 14/26 (53%), Positives = 16/26 (61%)
Frame = +3
Query: 24 EQTEHGVKWKTSSSQRFRQDGSTLVS 101
E HGV WK S SQR+ GST+ S
Sbjct: 3067 EAGHHGVMWKNSLSQRYHNSGSTMHS 3092
>UniRef50_O28464 Cluster: Inosine monophosphate cyclohydrolase; n=1;
Archaeoglobus fulgidus|Rep: Inosine monophosphate
cyclohydrolase - Archaeoglobus fulgidus
Length = 157
Score = 33.1 bits (72), Expect = 7.9
Identities = 16/37 (43%), Positives = 24/37 (64%)
Frame = +1
Query: 61 LLSVSDKTGLLSLAKSLSECGLQLIASXGTATXASER 171
L+S S K G+ LAK L+E G +++A+ GTA E+
Sbjct: 4 LISSSVKEGIECLAKRLAEMGYEILATEGTADYLQEK 40
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 666,744,951
Number of Sequences: 1657284
Number of extensions: 11709046
Number of successful extensions: 29739
Number of sequences better than 10.0: 54
Number of HSP's better than 10.0 without gapping: 28825
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 29682
length of database: 575,637,011
effective HSP length: 99
effective length of database: 411,565,895
effective search space used: 65027411410
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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