Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fbpv0116
(596 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P31939 Cluster: Bifunctional purine biosynthesis protei... 105 6e-22
UniRef50_Q4SHT8 Cluster: Chromosome 5 SCAF14581, whole genome sh... 103 3e-21
UniRef50_P67543 Cluster: Bifunctional purine biosynthesis protei... 83 5e-15
UniRef50_P43852 Cluster: Bifunctional purine biosynthesis protei... 79 1e-13
UniRef50_Q8PYG4 Cluster: Formyltransferase phosphoribosylaminoim... 77 2e-13
UniRef50_Q73LG8 Cluster: Phosphoribosylaminoimidazolecarboxamide... 77 4e-13
UniRef50_Q8ZAR3 Cluster: Bifunctional purine biosynthesis protei... 75 1e-12
UniRef50_Q8CXK7 Cluster: Bifunctional purine biosynthesis protei... 75 1e-12
UniRef50_Q8F3W6 Cluster: Bifunctional purine biosynthesis protei... 75 1e-12
UniRef50_P12048 Cluster: Bifunctional purine biosynthesis protei... 75 1e-12
UniRef50_P74741 Cluster: Bifunctional purine biosynthesis protei... 74 2e-12
UniRef50_Q2JR47 Cluster: Bifunctional purine biosynthesis protei... 73 7e-12
UniRef50_Q550I9 Cluster: AICAR transformylase / IMP cyclohydrola... 73 7e-12
UniRef50_A1K9K5 Cluster: Phosphoribosylaminoimidazolecarboxamide... 72 1e-11
UniRef50_Q2JI00 Cluster: Bifunctional purine biosynthesis protei... 71 2e-11
UniRef50_Q6MIZ2 Cluster: IMP cyclohydrolase; n=1; Bdellovibrio b... 71 3e-11
UniRef50_A7HM64 Cluster: IMP cyclohydrolase; n=1; Fervidobacteri... 68 2e-10
UniRef50_Q9PC10 Cluster: Bifunctional purine biosynthesis protei... 67 3e-10
UniRef50_Q83EI4 Cluster: Phosphoribosylaminoimidazolecarboxamide... 65 1e-09
UniRef50_Q8D244 Cluster: Bifunctional purine biosynthesis protei... 64 3e-09
UniRef50_Q9F1T4 Cluster: Bifunctional purine biosynthesis protei... 63 4e-09
UniRef50_A7BET6 Cluster: Putative uncharacterized protein; n=1; ... 62 7e-09
UniRef50_A5E8X1 Cluster: Phosphoribosylaminoimidazolecarboxamide... 62 7e-09
UniRef50_A7DF55 Cluster: Phosphoribosylaminoimidazolecarboxamide... 62 1e-08
UniRef50_Q9RW01 Cluster: Bifunctional purine biosynthesis protei... 60 3e-08
UniRef50_UPI00015BCE7E Cluster: UPI00015BCE7E related cluster; n... 60 4e-08
UniRef50_A6G003 Cluster: Bifunctional phosphoribosylaminoimidazo... 60 5e-08
UniRef50_A0JTW4 Cluster: Phosphoribosylaminoimidazolecarboxamide... 59 9e-08
UniRef50_Q7X311 Cluster: Putative AICAR transformylase; n=1; unc... 58 1e-07
UniRef50_Q9FPL3 Cluster: Phosphoribosylaminoimidazolecarboxamide... 58 1e-07
UniRef50_A2SS05 Cluster: Phosphoribosylaminoimidazolecarboxamide... 58 2e-07
UniRef50_Q1V178 Cluster: Bifunctional purine biosynthesis protei... 56 5e-07
UniRef50_A1IEQ8 Cluster: IMP cyclohydrolase; n=1; Candidatus Des... 56 6e-07
UniRef50_O67775 Cluster: Bifunctional purine biosynthesis protei... 56 6e-07
UniRef50_Q8XMK2 Cluster: Bifunctional purine biosynthesis protei... 55 1e-06
UniRef50_Q316G8 Cluster: Phosphoribosylaminoimidazolecarboxamide... 55 1e-06
UniRef50_Q8G6B1 Cluster: Bifunctional purine biosynthesis protei... 54 2e-06
UniRef50_Q9PNY2 Cluster: Bifunctional purine biosynthesis protei... 54 3e-06
UniRef50_Q83GZ1 Cluster: Phosphoribosylaminoimidazolecarboxamide... 52 8e-06
UniRef50_Q7VRP9 Cluster: Phosphoribosylaminoimidazolecarboxamide... 51 2e-05
UniRef50_Q7MUT5 Cluster: Phosphoribosylaminoimidazolecarboxamide... 50 3e-05
UniRef50_A7I7L2 Cluster: Phosphoribosylaminoimidazolecarboxamide... 50 4e-05
UniRef50_Q6L122 Cluster: Phosphoribosylaminoimidazolecarboxamide... 49 7e-05
UniRef50_Q89B23 Cluster: Bifunctional purine biosynthesis protei... 48 1e-04
UniRef50_A4MAE3 Cluster: Phosphoribosylaminoimidazolecarboxamide... 48 2e-04
UniRef50_Q8A155 Cluster: Bifunctional purine biosynthesis protei... 48 2e-04
UniRef50_A1G3C3 Cluster: Phosphoribosylaminoimidazolecarboxamide... 47 4e-04
UniRef50_Q9X0X6 Cluster: Bifunctional purine biosynthesis protei... 44 0.003
UniRef50_Q3JNS9 Cluster: Putative uncharacterized protein; n=9; ... 41 0.019
UniRef50_A7PK27 Cluster: Chromosome chr15 scaffold_19, whole gen... 40 0.044
UniRef50_A5B1A5 Cluster: DNA-directed RNA polymerase; n=1; Vitis... 40 0.044
UniRef50_A5B3D8 Cluster: DNA-directed RNA polymerase; n=1; Vitis... 36 0.72
UniRef50_A1HBX2 Cluster: Putative uncharacterized protein; n=2; ... 35 1.7
UniRef50_A4M1L4 Cluster: Putative uncharacterized protein; n=1; ... 34 2.2
UniRef50_UPI0000382898 Cluster: COG0138: AICAR transformylase/IM... 33 5.1
UniRef50_Q01GS0 Cluster: Chromosome 01 contig 1, DNA sequence; n... 33 6.7
UniRef50_O28464 Cluster: Inosine monophosphate cyclohydrolase; n... 33 6.7
UniRef50_O67501 Cluster: Inorganic pyrophosphatase; n=37; Bacter... 33 6.7
>UniRef50_P31939 Cluster: Bifunctional purine biosynthesis protein
PURH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3)
(5-aminoimidazole-4-carboxamide ribonucleotide
formyltransferase) (AICAR transformylase); IMP
cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=105; cellular organisms|Rep:
Bifunctional purine biosynthesis protein PURH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3)
(5-aminoimidazole-4-carboxamide ribonucleotide
formyltransferase) (AICAR transformylase); IMP
cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Homo sapiens (Human)
Length = 592
Score = 105 bits (253), Expect = 6e-22
Identities = 84/208 (40%), Positives = 106/208 (50%), Gaps = 10/208 (4%)
Frame = +2
Query: 2 AXXKLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERRPHSSRCVGHHEXTGDA 181
A +LAL SVSDKTGL+ A++L+ GL L+ASGGTA A + R V E TG
Sbjct: 2 APGQLALFSVSDKTGLVEFARNLTALGLNLVASGGTAK-ALRDAGLAVRDVS--ELTGFP 58
Query: 182 RRSGENFTSSGTCWDLSSIIRL*PED---MKRQKYEMISXVXCNLYPFVQTVSKPDVTVA 352
G + + R PED M R + +I V CNLYPFV+TV+ P VTV
Sbjct: 59 EMLGGRVKTLHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVE 118
Query: 353 DAVENIDIGGVTLLRAQPR-----TTTGSPSSVTRPTTML*SKXSKRTNI--IRRLXAQA 511
+AVE IDIGGVTLLRA + T P +T + S SK T++ R+L +A
Sbjct: 119 EAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKA 178
Query: 512 EISPEGVSLILSDYDLRHIRTTFRKQYS 595
+SDY FRKQYS
Sbjct: 179 FTHTAQYDEAISDY--------FRKQYS 198
Score = 70.1 bits (164), Expect = 4e-11
Identities = 32/41 (78%), Positives = 37/41 (90%)
Frame = +3
Query: 114 RXLRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILAR 236
+ LR+AGL V+DVS++T PEMLGGRVKTLHPAVHAGILAR
Sbjct: 39 KALRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILAR 79
>UniRef50_Q4SHT8 Cluster: Chromosome 5 SCAF14581, whole genome
shotgun sequence; n=3; Euteleostomi|Rep: Chromosome 5
SCAF14581, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 628
Score = 103 bits (247), Expect = 3e-21
Identities = 64/131 (48%), Positives = 75/131 (57%), Gaps = 3/131 (2%)
Frame = +2
Query: 17 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERR---PHSSRCVGHHEXTGDARR 187
ALLSVSDKTGL+ AK L + GL L+ASGGTA + S GH E G +
Sbjct: 1 ALLSVSDKTGLVQFAKRLVDVGLSLVASGGTAKTLRDAGWAVRDVSELTGHPEMLGGRVK 60
Query: 188 SGENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAVEN 367
+ G L+ DM++ Y +I V CNLYPFV+TVS P VTV DAVE
Sbjct: 61 TLHPAVHGGI---LARKSPADTADMEKLGYSLIRVVVCNLYPFVKTVSNPSVTVEDAVEQ 117
Query: 368 IDIGGVTLLRA 400
IDIGGVTLLRA
Sbjct: 118 IDIGGVTLLRA 128
Score = 39.5 bits (88), Expect = 0.059
Identities = 18/35 (51%), Positives = 22/35 (62%)
Frame = +1
Query: 403 AKNHDRVTVVCDPADYDAVVKXIKENKHHQTTXGT 507
AKNH RVTVVCDPADY V + ++ + T T
Sbjct: 130 AKNHARVTVVCDPADYPRVAEEMEGSGSRDTPSRT 164
>UniRef50_P67543 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=18; Staphylococcus|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Staphylococcus aureus (strain Mu50
/ ATCC 700699)
Length = 492
Score = 83.0 bits (196), Expect = 5e-15
Identities = 51/133 (38%), Positives = 74/133 (55%), Gaps = 3/133 (2%)
Frame = +2
Query: 11 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERRP--HSSRCVGHHEXTGDAR 184
K A+LSVS+KTG++ AK+L++ +L ++GGT E S + H D R
Sbjct: 2 KKAILSVSNKTGIVEFAKALTQLNYELYSTGGTKRILDEANVPVRSVSDLTHFPEIMDGR 61
Query: 185 -RSGENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAV 361
++ G D + L ++ Q ++I V NLYPF QTV+ PDVT+ +A+
Sbjct: 62 VKTLHPAVHGGILADRNKPQHL--NELSEQHIDLIDMVVVNLYPFQQTVANPDVTMDEAI 119
Query: 362 ENIDIGGVTLLRA 400
ENIDIGG T+LRA
Sbjct: 120 ENIDIGGPTMLRA 132
>UniRef50_P43852 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=88; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Haemophilus influenzae
Length = 532
Score = 78.6 bits (185), Expect = 1e-13
Identities = 50/130 (38%), Positives = 75/130 (57%), Gaps = 2/130 (1%)
Frame = +2
Query: 17 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERRPHSSRCVGHHEXTGDARRSGE 196
ALLSVSDKTG++ A+ L + G++L+++GGTA ++ ++ + + TG
Sbjct: 9 ALLSVSDKTGIVEFAQGLVKRGVKLLSTGGTAKLLAQ---NALPVIEVSDYTGFPEMMDG 65
Query: 197 NFTSSGTCWDLSSIIRL*PED--MKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAVENI 370
+ + R +D M++ E I V NLYPF TV+KPD T+ADAVENI
Sbjct: 66 RVKTLHPKVHGGILGRRGTDDAIMQQHGIEGIDMVVVNLYPFAATVAKPDCTLADAVENI 125
Query: 371 DIGGVTLLRA 400
DIGG T++R+
Sbjct: 126 DIGGPTMVRS 135
Score = 51.6 bits (118), Expect = 1e-05
Identities = 25/46 (54%), Positives = 28/46 (60%)
Frame = +3
Query: 114 RXLRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILARLSDSD 251
+ L L V +VSD T PEM+ GRVKTLHP VH GIL R D
Sbjct: 41 KLLAQNALPVIEVSDYTGFPEMMDGRVKTLHPKVHGGILGRRGTDD 86
>UniRef50_Q8PYG4 Cluster: Formyltransferase
phosphoribosylaminoimidazolecarboxamide; n=4;
Methanosarcinaceae|Rep: Formyltransferase
phosphoribosylaminoimidazolecarboxamide - Methanosarcina
mazei (Methanosarcina frisia)
Length = 538
Score = 77.4 bits (182), Expect = 2e-13
Identities = 49/133 (36%), Positives = 73/133 (54%), Gaps = 3/133 (2%)
Frame = +2
Query: 11 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATX---ASERRPHSSRCVGHHEXTGDA 181
K ALLSVSDKTG++ A+ L G+++I++GGTA A S G+ E G
Sbjct: 3 KRALLSVSDKTGIVEFARGLEALGVKIISTGGTAKILRDADIEVTDVSEVTGYPEMMGGR 62
Query: 182 RRSGENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAV 361
++ G S ++ E+ ++ +I + NLYPF TVS+ +V + +A+
Sbjct: 63 VKTLHPRIHGGLLCLRESKEQM--EEAAKEDISLIDLIAVNLYPFEITVSRENVELEEAI 120
Query: 362 ENIDIGGVTLLRA 400
ENIDIGG TLLR+
Sbjct: 121 ENIDIGGPTLLRS 133
Score = 57.6 bits (133), Expect = 2e-07
Identities = 24/47 (51%), Positives = 33/47 (70%)
Frame = +3
Query: 114 RXLRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILARLSDSDQ 254
+ LR+A + V DVS++T PEM+GGRVKTLHP +H G+L +Q
Sbjct: 37 KILRDADIEVTDVSEVTGYPEMMGGRVKTLHPRIHGGLLCLRESKEQ 83
>UniRef50_Q73LG8 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=2; Bacteria|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Treponema
denticola
Length = 533
Score = 76.6 bits (180), Expect = 4e-13
Identities = 52/132 (39%), Positives = 64/132 (48%), Gaps = 3/132 (2%)
Frame = +2
Query: 14 LALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASE---RRPHSSRCVGHHEXTGDAR 184
L L SVSDKTGL A L G IASGGTA E + S E G
Sbjct: 3 LVLASVSDKTGLKDFAFRLKAAGYDFIASGGTAKTLQEAGIKVKEVSEYTSSPEILGGRV 62
Query: 185 RSGENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAVE 364
++ G L+ + ++K + I V NLYPF +T+S PD T +D +E
Sbjct: 63 KTLHPMIHGGI---LARDTKEDRAELKALGFSGIDIVIANLYPFEKTISSPDSTESDCIE 119
Query: 365 NIDIGGVTLLRA 400
NIDIGGV LLRA
Sbjct: 120 NIDIGGVALLRA 131
Score = 60.1 bits (139), Expect = 4e-08
Identities = 26/47 (55%), Positives = 36/47 (76%)
Frame = +3
Query: 114 RXLRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILARLSDSDQ 254
+ L+ AG+ V++VS+ T PE+LGGRVKTLHP +H GILAR + D+
Sbjct: 36 KTLQEAGIKVKEVSEYTSSPEILGGRVKTLHPMIHGGILARDTKEDR 82
Score = 39.9 bits (89), Expect = 0.044
Identities = 16/25 (64%), Positives = 20/25 (80%)
Frame = +1
Query: 403 AKNHDRVTVVCDPADYDAVVKXIKE 477
AKN+ RVTV+CDPADYD V I++
Sbjct: 133 AKNYSRVTVICDPADYDEVSSEIEK 157
>UniRef50_Q8ZAR3 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=59; Proteobacteria|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Yersinia pestis
Length = 529
Score = 74.9 bits (176), Expect = 1e-12
Identities = 47/130 (36%), Positives = 73/130 (56%), Gaps = 2/130 (1%)
Frame = +2
Query: 17 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERRPHSSRCVGHHEXTGDARRSGE 196
ALLSVSDK G++ A++LS+ G++L+++GGTA ++ + + TG
Sbjct: 10 ALLSVSDKAGIIEFAQALSQRGIELLSTGGTARLLADAGLPVTEV---SDYTGFPEMMDG 66
Query: 197 NFTSSGTCWDLSSIIRL*PED--MKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAVENI 370
+ + R +D M + + I V NLYPF QTV++PD ++ DAVENI
Sbjct: 67 RVKTLHPKVHGGILGRRGQDDGIMAQHGIQPIDIVVVNLYPFAQTVARPDCSLEDAVENI 126
Query: 371 DIGGVTLLRA 400
DIGG T++R+
Sbjct: 127 DIGGPTMVRS 136
Score = 59.3 bits (137), Expect = 7e-08
Identities = 28/46 (60%), Positives = 31/46 (67%)
Frame = +3
Query: 114 RXLRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILARLSDSD 251
R L +AGL V +VSD T PEM+ GRVKTLHP VH GIL R D
Sbjct: 42 RLLADAGLPVTEVSDYTGFPEMMDGRVKTLHPKVHGGILGRRGQDD 87
>UniRef50_Q8CXK7 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=34; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Oceanobacillus iheyensis
Length = 510
Score = 74.9 bits (176), Expect = 1e-12
Identities = 47/133 (35%), Positives = 67/133 (50%), Gaps = 3/133 (2%)
Frame = +2
Query: 11 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERRPHSS---RCVGHHEXTGDA 181
K AL+SVSDKT ++ AK L E G +++++GGT +E + G E
Sbjct: 3 KRALISVSDKTNIIEFAKGLKESGFEILSTGGTLRSIAEAGIDVTPVDEVTGFPEMLDGR 62
Query: 182 RRSGENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAV 361
++ G S+ L M+ I V NLYPF +TV KPDV+ D +
Sbjct: 63 VKTLHPMIHGGLLGKRSNHEHL--SQMEEHGIRSIDLVAVNLYPFKETVQKPDVSHQDII 120
Query: 362 ENIDIGGVTLLRA 400
ENIDIGG ++LR+
Sbjct: 121 ENIDIGGPSMLRS 133
Score = 52.8 bits (121), Expect = 6e-06
Identities = 22/46 (47%), Positives = 31/46 (67%)
Frame = +3
Query: 114 RXLRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILARLSDSD 251
R + AG+ V V ++T PEML GRVKTLHP +H G+L + S+ +
Sbjct: 37 RSIAEAGIDVTPVDEVTGFPEMLDGRVKTLHPMIHGGLLGKRSNHE 82
>UniRef50_Q8F3W6 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=6; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Leptospira interrogans
Length = 511
Score = 74.9 bits (176), Expect = 1e-12
Identities = 46/133 (34%), Positives = 74/133 (55%), Gaps = 3/133 (2%)
Frame = +2
Query: 11 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERRPHSSRC---VGHHEXTGDA 181
K AL+SVSDK+GL+ AK L++ G+++I++GGT + + G E
Sbjct: 5 KRALISVSDKSGLVEFAKFLNQNGVEIISTGGTLKLLKDNGIAAIAIDDYTGFPEILDGR 64
Query: 182 RRSGENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAV 361
++ G +S+ + M+ K I V NLYPF++TVSKP+V + +A+
Sbjct: 65 VKTLHPKVHGGLLGVISNPAH--KQKMEELKIPKIDLVVVNLYPFLKTVSKPEVQLEEAI 122
Query: 362 ENIDIGGVTLLRA 400
ENIDIGG +++R+
Sbjct: 123 ENIDIGGPSMIRS 135
Score = 47.6 bits (108), Expect = 2e-04
Identities = 21/48 (43%), Positives = 30/48 (62%)
Frame = +3
Query: 114 RXLRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILARLSDSDQK 257
+ L++ G+ + D T PE+L GRVKTLHP VH G+L +S+ K
Sbjct: 39 KLLKDNGIAAIAIDDYTGFPEILDGRVKTLHPKVHGGLLGVISNPAHK 86
>UniRef50_P12048 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=71; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Bacillus subtilis
Length = 512
Score = 74.9 bits (176), Expect = 1e-12
Identities = 52/134 (38%), Positives = 70/134 (52%), Gaps = 4/134 (2%)
Frame = +2
Query: 11 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERRPHSSRCVGHHEXTGDAR-R 187
K AL+SVSDKT L+ K L+E G+++I++GGT E + +G E TG
Sbjct: 4 KRALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQE---NGVDVIGISEVTGFPEIM 60
Query: 188 SGENFTSSGTCWDLSSIIRL*PEDMKR---QKYEMISXVXCNLYPFVQTVSKPDVTVADA 358
G T +R E M + + I V NLYPF +T+SK DVT +A
Sbjct: 61 DGRLKTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVNLYPFKETISKEDVTYEEA 120
Query: 359 VENIDIGGVTLLRA 400
+ENIDIGG +LRA
Sbjct: 121 IENIDIGGPGMLRA 134
Score = 46.0 bits (104), Expect = 7e-04
Identities = 18/40 (45%), Positives = 29/40 (72%)
Frame = +3
Query: 114 RXLRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILA 233
+ L+ G+ V +S++T PE++ GR+KTLHP +H G+LA
Sbjct: 38 KLLQENGVDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLA 77
Score = 36.3 bits (80), Expect = 0.55
Identities = 15/25 (60%), Positives = 18/25 (72%)
Frame = +1
Query: 403 AKNHDRVTVVCDPADYDAVVKXIKE 477
+KNH VTV+ DPADY V+ IKE
Sbjct: 136 SKNHQDVTVIVDPADYSPVLNQIKE 160
>UniRef50_P74741 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=49; root|Rep: Bifunctional purine
biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Synechocystis sp. (strain PCC
6803)
Length = 511
Score = 74.1 bits (174), Expect = 2e-12
Identities = 54/136 (39%), Positives = 73/136 (53%), Gaps = 6/136 (4%)
Frame = +2
Query: 11 KLALLSVSDKTGLLSLAKSL-SECGLQLIASGGTATXASERRPHSSRC---VGHHEXTGD 178
+LALLSVSDK+G++ LA+ L +E LI+SGGTA E ++ G E G
Sbjct: 3 RLALLSVSDKSGIVELAQRLVNEFQFDLISSGGTAKTLKEAGVPVTKVSDYTGAPEILGG 62
Query: 179 ARRSGENFTSSGTCW--DLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVA 352
++ G DL S D++ + V NLYPF QT++KP VTVA
Sbjct: 63 RVKTLHPRIHGGILARRDLPSD----QADLEANDIRPLDLVVVNLYPFEQTIAKPGVTVA 118
Query: 353 DAVENIDIGGVTLLRA 400
+AVE IDIGG ++RA
Sbjct: 119 EAVEQIDIGGPAMIRA 134
Score = 58.4 bits (135), Expect = 1e-07
Identities = 29/48 (60%), Positives = 34/48 (70%), Gaps = 1/48 (2%)
Frame = +3
Query: 114 RXLRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILARLS-DSDQ 254
+ L+ AG+ V VSD T PE+LGGRVKTLHP +H GILAR SDQ
Sbjct: 38 KTLKEAGVPVTKVSDYTGAPEILGGRVKTLHPRIHGGILARRDLPSDQ 85
>UniRef50_Q2JR47 Cluster: Bifunctional purine biosynthesis protein
PurH; n=12; Bacteria|Rep: Bifunctional purine
biosynthesis protein PurH - Synechococcus sp. (strain
JA-3-3Ab) (Cyanobacteria bacteriumYellowstone A-Prime)
Length = 537
Score = 72.5 bits (170), Expect = 7e-12
Identities = 56/133 (42%), Positives = 71/133 (53%), Gaps = 4/133 (3%)
Frame = +2
Query: 14 LALLSVSDKTGLLSLAKSL-SECGLQLIASGGTATXASERR-PHS--SRCVGHHEXTGDA 181
LALLSVSDKTGL+ LA++L E G QL++SGGTA SE P + S G E G
Sbjct: 9 LALLSVSDKTGLIPLAQALVQEHGFQLLSSGGTAKALSEAGIPVTPVSEHTGAPEILGGR 68
Query: 182 RRSGENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAV 361
++ G L R D++ I V N YPF QTV++ V++ +A
Sbjct: 69 VKTLHPRIHGGILARLER--REDRADLEALGIPPIQLVVVNFYPFEQTVARAGVSLEEAF 126
Query: 362 ENIDIGGVTLLRA 400
E IDIGG TL RA
Sbjct: 127 EQIDIGGPTLARA 139
Score = 56.8 bits (131), Expect = 4e-07
Identities = 26/48 (54%), Positives = 33/48 (68%)
Frame = +3
Query: 114 RXLRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILARLSDSDQK 257
+ L AG+ V VS+ T PE+LGGRVKTLHP +H GILARL + +
Sbjct: 43 KALSEAGIPVTPVSEHTGAPEILGGRVKTLHPRIHGGILARLERREDR 90
>UniRef50_Q550I9 Cluster: AICAR transformylase / IMP cyclohydrolase;
n=2; Dictyostelium discoideum|Rep: AICAR transformylase
/ IMP cyclohydrolase - Dictyostelium discoideum AX4
Length = 542
Score = 72.5 bits (170), Expect = 7e-12
Identities = 48/133 (36%), Positives = 69/133 (51%), Gaps = 2/133 (1%)
Frame = +2
Query: 17 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASER--RPHSSRCVGHHEXTGDARRS 190
ALLSV +K+G++ +K LS G LI++GGTA + + V + D R
Sbjct: 3 ALLSVYNKSGIVEFSKILSSKGFNLISTGGTAKSLVDNGLKVQQVSDVTEYPEMLDGRVK 62
Query: 191 GENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAVENI 370
+ G + D+ + + IS V NLYPFV+TVSK T+ +A+ENI
Sbjct: 63 TLHPKIHGGLLARPELAHH-QADLNKYNIKPISIVVVNLYPFVETVSKESTTLEEAIENI 121
Query: 371 DIGGVTLLRAQPR 409
DIGG TL+RA +
Sbjct: 122 DIGGHTLIRASSK 134
Score = 58.4 bits (135), Expect = 1e-07
Identities = 26/41 (63%), Positives = 31/41 (75%)
Frame = +3
Query: 114 RXLRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILAR 236
+ L + GL VQ VSD+T PEML GRVKTLHP +H G+LAR
Sbjct: 35 KSLVDNGLKVQQVSDVTEYPEMLDGRVKTLHPKIHGGLLAR 75
>UniRef50_A1K9K5 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=2; Bacteria|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Azoarcus sp.
(strain BH72)
Length = 527
Score = 71.7 bits (168), Expect = 1e-11
Identities = 50/149 (33%), Positives = 72/149 (48%), Gaps = 6/149 (4%)
Frame = +2
Query: 17 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERR---PHSSRCVGHHEXTGDARR 187
AL+SVSDK G+L A+ L+ G++L+++GGTA + S G E +
Sbjct: 6 ALISVSDKRGVLDFARELAGLGIKLLSTGGTAALLRDAGLPVTDVSEHTGFPEMLDGRVK 65
Query: 188 SGENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAVEN 367
+ G + + + I V NLYPF TV++PD T+ DA+EN
Sbjct: 66 TLHPKVHGGILARRDLAEHM--DTIAAHDISRIDLVVVNLYPFQATVARPDCTLEDAIEN 123
Query: 368 IDIGGVTLLRAQPR---TTTGSPSSVTRP 445
IDIGG T++RA + T G VT P
Sbjct: 124 IDIGGPTMVRAAAKNHGTEAGGVGIVTDP 152
Score = 60.1 bits (139), Expect = 4e-08
Identities = 29/39 (74%), Positives = 31/39 (79%)
Frame = +3
Query: 120 LRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILAR 236
LR+AGL V DVS+ T PEML GRVKTLHP VH GILAR
Sbjct: 40 LRDAGLPVTDVSEHTGFPEMLDGRVKTLHPKVHGGILAR 78
>UniRef50_Q2JI00 Cluster: Bifunctional purine biosynthesis protein
PurH; n=1; Synechococcus sp. JA-2-3B'a(2-13)|Rep:
Bifunctional purine biosynthesis protein PurH -
Synechococcus sp. (strain JA-2-3B'a(2-13))
(Cyanobacteria bacteriumYellowstone B-Prime)
Length = 577
Score = 71.3 bits (167), Expect = 2e-11
Identities = 56/134 (41%), Positives = 70/134 (52%), Gaps = 5/134 (3%)
Frame = +2
Query: 14 LALLSVSDKTGLLSLAKSL-SECGLQLIASGGTATXASER----RPHSSRCVGHHEXTGD 178
LALLSVSDKTGL+ LA+SL E G QL++SGGTA SE P S+ G E G
Sbjct: 17 LALLSVSDKTGLIPLAQSLVQEHGFQLLSSGGTAKALSEAGIPVTPVSAH-TGAPEILGG 75
Query: 179 ARRSGENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADA 358
++ G L D++ I V N YPF QTV++ V++ +A
Sbjct: 76 RVKTLHPRIHGGILARLECSED--RADLEALGIPPIQLVVVNFYPFEQTVAQAGVSLEEA 133
Query: 359 VENIDIGGVTLLRA 400
E IDIGG TL RA
Sbjct: 134 FEQIDIGGPTLARA 147
Score = 56.8 bits (131), Expect = 4e-07
Identities = 27/48 (56%), Positives = 33/48 (68%)
Frame = +3
Query: 114 RXLRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILARLSDSDQK 257
+ L AG+ V VS T PE+LGGRVKTLHP +H GILARL S+ +
Sbjct: 51 KALSEAGIPVTPVSAHTGAPEILGGRVKTLHPRIHGGILARLECSEDR 98
>UniRef50_Q6MIZ2 Cluster: IMP cyclohydrolase; n=1; Bdellovibrio
bacteriovorus|Rep: IMP cyclohydrolase - Bdellovibrio
bacteriovorus
Length = 507
Score = 70.5 bits (165), Expect = 3e-11
Identities = 53/132 (40%), Positives = 67/132 (50%), Gaps = 4/132 (3%)
Frame = +2
Query: 17 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERRPHSSRCVGHHEXTGDARRSGE 196
ALLSVSDKTGLL LAK+L+ ++LIASGGTA +E + +G
Sbjct: 7 ALLSVSDKTGLLELAKNLAAQNVELIASGGTAKALTEA---GLKVTAVETLSGKGEAFNG 63
Query: 197 NFTSSGTCWDLSSIIRL*PEDMKRQKYEM----ISXVXCNLYPFVQTVSKPDVTVADAVE 364
+ S + R E+ RQ E+ I V NLYPF T+ K + +E
Sbjct: 64 RMKTISFEIASSLLFRRQDENDVRQAAELGIEPIDLVVVNLYPFHATLQK-QAGFEECIE 122
Query: 365 NIDIGGVTLLRA 400
NIDIGG TLLRA
Sbjct: 123 NIDIGGPTLLRA 134
>UniRef50_A7HM64 Cluster: IMP cyclohydrolase; n=1; Fervidobacterium
nodosum Rt17-B1|Rep: IMP cyclohydrolase -
Fervidobacterium nodosum Rt17-B1
Length = 429
Score = 67.7 bits (158), Expect = 2e-10
Identities = 50/133 (37%), Positives = 67/133 (50%), Gaps = 3/133 (2%)
Frame = +2
Query: 11 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERR---PHSSRCVGHHEXTGDA 181
K AL+SVSDK GL+ AK+L + G+++I++GGTA S+ S G E G
Sbjct: 4 KRALISVSDKAGLVEFAKNLVDRGVEIISTGGTAKLLSDAGIPVKQVSDVTGFPEILGGR 63
Query: 182 RRSGENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAV 361
++ G DL + +D++ E I V NLYPF V K +
Sbjct: 64 VKTLHPKIFGGILADLGDKSHV--KDLRDNFIEPIDLVVVNLYPF-DEVQKKTRDEDVLI 120
Query: 362 ENIDIGGVTLLRA 400
ENIDIGGV LLRA
Sbjct: 121 ENIDIGGVALLRA 133
Score = 58.0 bits (134), Expect = 2e-07
Identities = 26/44 (59%), Positives = 33/44 (75%)
Frame = +3
Query: 114 RXLRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILARLSD 245
+ L +AG+ V+ VSD+T PE+LGGRVKTLHP + GILA L D
Sbjct: 38 KLLSDAGIPVKQVSDVTGFPEILGGRVKTLHPKIFGGILADLGD 81
Score = 41.1 bits (92), Expect = 0.019
Identities = 17/23 (73%), Positives = 18/23 (78%)
Frame = +1
Query: 403 AKNHDRVTVVCDPADYDAVVKXI 471
AKNH V VVCDPADYD V+K I
Sbjct: 135 AKNHRNVVVVCDPADYDKVIKSI 157
>UniRef50_Q9PC10 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=214; cellular organisms|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Xylella fastidiosa
Length = 527
Score = 67.3 bits (157), Expect = 3e-10
Identities = 47/131 (35%), Positives = 66/131 (50%), Gaps = 3/131 (2%)
Frame = +2
Query: 17 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERR---PHSSRCVGHHEXTGDARR 187
ALLSVSDKTGL+ LA++L ++L+++GGTAT E + G E +
Sbjct: 11 ALLSVSDKTGLVELARALLAYNIELLSTGGTATIIREAGLPVQDVADLTGFPEMMDGRVK 70
Query: 188 SGENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAVEN 367
+ G L + M + I + NLYPF Q +K D T+ADAV+
Sbjct: 71 TLHPMVHGG----LLGRAGIDDAVMAKHGIAPIDLLILNLYPFEQITAKKDCTLADAVDT 126
Query: 368 IDIGGVTLLRA 400
IDIGG +LR+
Sbjct: 127 IDIGGPAMLRS 137
Score = 61.3 bits (142), Expect = 2e-08
Identities = 27/44 (61%), Positives = 32/44 (72%)
Frame = +3
Query: 120 LRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILARLSDSD 251
+R AGL VQDV+D+T PEM+ GRVKTLHP VH G+L R D
Sbjct: 45 IREAGLPVQDVADLTGFPEMMDGRVKTLHPMVHGGLLGRAGIDD 88
>UniRef50_Q83EI4 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=5; Coxiella
burnetii|Rep: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Coxiella burnetii
Length = 526
Score = 64.9 bits (151), Expect = 1e-09
Identities = 43/132 (32%), Positives = 65/132 (49%), Gaps = 2/132 (1%)
Frame = +2
Query: 11 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERRPHSSRCVGHHEXTGDARRS 190
K AL+S +DK GL+ L CG+++IA+GGTA + H + TG
Sbjct: 12 KRALISTADKIGLIEFISQLVTCGVEIIATGGTAELLKQ---HQLPVIDVFTYTGFPEIM 68
Query: 191 GENFTSSGTCWDLSSIIR--L*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAVE 364
+ + R + + + + + I + NLYPFVQTVS + ++ AVE
Sbjct: 69 DGRVKTLHPKIHAGLLARRGIDEKTLDQHAIKPIDLLVVNLYPFVQTVSASNCSLEKAVE 128
Query: 365 NIDIGGVTLLRA 400
IDIGG ++LRA
Sbjct: 129 QIDIGGPSMLRA 140
Score = 48.4 bits (110), Expect = 1e-04
Identities = 25/47 (53%), Positives = 31/47 (65%)
Frame = +3
Query: 120 LRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILARLSDSDQKT 260
L+ L V DV T PE++ GRVKTLHP +HAG+LAR D+KT
Sbjct: 48 LKQHQLPVIDVFTYTGFPEIMDGRVKTLHPKIHAGLLAR-RGIDEKT 93
Score = 35.1 bits (77), Expect = 1.3
Identities = 19/46 (41%), Positives = 25/46 (54%)
Frame = +1
Query: 403 AKNHDRVTVVCDPADYDAVVKXIKENKHHQTTXGTSRD*P*RRFTH 540
AKN VTVV DP DY +++ IK + H TT T + + F H
Sbjct: 142 AKNFAAVTVVVDPEDYSRILEEIKTH-HGSTTLSTRKRLAQKTFEH 186
>UniRef50_Q8D244 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=2; Gammaproteobacteria|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Wigglesworthia glossinidia
brevipalpis
Length = 529
Score = 63.7 bits (148), Expect = 3e-09
Identities = 43/133 (32%), Positives = 67/133 (50%), Gaps = 3/133 (2%)
Frame = +2
Query: 11 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERRPHS---SRCVGHHEXTGDA 181
+ AL+SVSDKTG+ SLAK+L + ++LI + GT E+ S S + H E
Sbjct: 9 RCALISVSDKTGIFSLAKNLIKHKVKLITTSGTYKYLLEKGIFSTSVSEYINHPEIINGR 68
Query: 182 RRSGENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAV 361
++ G + +I + K + I V N YPF + V K ++ + + +
Sbjct: 69 VKTLHPKIHGGILSNNKNI-----NENKNLNIKKIDMVITNFYPFKKKVKKENIKIENII 123
Query: 362 ENIDIGGVTLLRA 400
+NIDIGGV L R+
Sbjct: 124 DNIDIGGVALARS 136
Score = 43.6 bits (98), Expect = 0.004
Identities = 20/54 (37%), Positives = 32/54 (59%), Gaps = 1/54 (1%)
Frame = +3
Query: 114 RXLRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILARLSD-SDQKT*NVR 272
+ L G+ VS+ PE++ GRVKTLHP +H GIL+ + ++ K N++
Sbjct: 43 KYLLEKGIFSTSVSEYINHPEIINGRVKTLHPKIHGGILSNNKNINENKNLNIK 96
>UniRef50_Q9F1T4 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=57; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Streptococcus suis
Length = 515
Score = 63.3 bits (147), Expect = 4e-09
Identities = 45/135 (33%), Positives = 69/135 (51%), Gaps = 5/135 (3%)
Frame = +2
Query: 11 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERRPHS---SRCVGHHEXTGDA 181
K AL+SVSDK G++ A+ L++ G ++I++GGT + + G E
Sbjct: 3 KRALISVSDKNGIVEFAQELTKFGWEIISTGGTKVALDQAGVTTIAIDDVTGFPEMMDGR 62
Query: 182 RRSGENFTSSGTCW--DLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVAD 355
++ G DL S ++ + +I V NLYPF +T+ +PDVT
Sbjct: 63 VKTLHPKIHGGLLARRDLDSHLQA----ANDHEIGLIDLVVVNLYPFKETILRPDVTYDL 118
Query: 356 AVENIDIGGVTLLRA 400
AVENIDIGG ++LR+
Sbjct: 119 AVENIDIGGPSMLRS 133
Score = 52.4 bits (120), Expect = 8e-06
Identities = 22/39 (56%), Positives = 28/39 (71%)
Frame = +3
Query: 120 LRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILAR 236
L AG+T + D+T PEM+ GRVKTLHP +H G+LAR
Sbjct: 39 LDQAGVTTIAIDDVTGFPEMMDGRVKTLHPKIHGGLLAR 77
Score = 37.1 bits (82), Expect = 0.31
Identities = 24/63 (38%), Positives = 33/63 (52%)
Frame = +1
Query: 403 AKNHDRVTVVCDPADYDAVVKXIKENKHHQTTXGTSRD*P*RRFTHTFGL*PSPYSDYFP 582
AKNH VTVV DPADY V+ I E +T+ T + + F HT + +DYF
Sbjct: 135 AKNHASVTVVVDPADYPTVLGEIAE--QGETSYATRQRLAAKVFRHTAAY-DALIADYFT 191
Query: 583 QAI 591
+ +
Sbjct: 192 KQV 194
>UniRef50_A7BET6 Cluster: Putative uncharacterized protein; n=1;
Actinomyces odontolyticus ATCC 17982|Rep: Putative
uncharacterized protein - Actinomyces odontolyticus ATCC
17982
Length = 614
Score = 62.5 bits (145), Expect = 7e-09
Identities = 48/148 (32%), Positives = 70/148 (47%), Gaps = 3/148 (2%)
Frame = +2
Query: 11 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATX---ASERRPHSSRCVGHHEXTGDA 181
K AL+SV DKTGL LA++L E G++++++G TA A G E
Sbjct: 17 KRALISVYDKTGLEDLARALGEAGVEIVSTGSTAARIAAAGVAVTPVDDVTGFPEVLEGR 76
Query: 182 RRSGENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAV 361
++ F SG D E + + + V CNLYPF TV+ + + V
Sbjct: 77 VKTLHPFIHSGILADQRKAAHR--EQIAQLGIQAFDLVVCNLYPFQDTVAS-GASFDECV 133
Query: 362 ENIDIGGVTLLRAQPRTTTGSPSSVTRP 445
E IDIGG +++RA + S + VT P
Sbjct: 134 EQIDIGGPSMVRAAAKNHP-SVAVVTSP 160
Score = 50.4 bits (115), Expect = 3e-05
Identities = 22/35 (62%), Positives = 27/35 (77%)
Frame = +3
Query: 129 AGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILA 233
AG+ V V D+T PE+L GRVKTLHP +H+GILA
Sbjct: 56 AGVAVTPVDDVTGFPEVLEGRVKTLHPFIHSGILA 90
>UniRef50_A5E8X1 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase /IMP cyclohydrolase; n=4;
Bacteria|Rep: Phosphoribosylaminoimidazolecarboxamide
formyltransferase /IMP cyclohydrolase - Bradyrhizobium
sp. (strain BTAi1 / ATCC BAA-1182)
Length = 530
Score = 62.5 bits (145), Expect = 7e-09
Identities = 47/131 (35%), Positives = 64/131 (48%), Gaps = 3/131 (2%)
Frame = +2
Query: 17 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTA---TXASERRPHSSRCVGHHEXTGDARR 187
ALLSVSDKTGL+ A+SL+ G++LI++GGTA A + S G E +
Sbjct: 11 ALLSVSDKTGLVEFARSLAARGIELISTGGTAKAIADAGLKVKDVSDLTGFPEMMDGRVK 70
Query: 188 SGENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAVEN 367
+ G + E MK I + NLYPF TV + +D +EN
Sbjct: 71 TLHPKVHGGLLAIRGNDEH--AEAMKTHGIAPIDLLVVNLYPFEATVER-SAPFSDCIEN 127
Query: 368 IDIGGVTLLRA 400
IDIGG ++RA
Sbjct: 128 IDIGGPAMIRA 138
Score = 58.0 bits (134), Expect = 2e-07
Identities = 25/40 (62%), Positives = 32/40 (80%)
Frame = +3
Query: 114 RXLRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILA 233
+ + +AGL V+DVSD+T PEM+ GRVKTLHP VH G+LA
Sbjct: 43 KAIADAGLKVKDVSDLTGFPEMMDGRVKTLHPKVHGGLLA 82
>UniRef50_A7DF55 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=3;
Alphaproteobacteria|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Methylobacterium
extorquens PA1
Length = 581
Score = 61.7 bits (143), Expect = 1e-08
Identities = 27/40 (67%), Positives = 33/40 (82%)
Frame = +3
Query: 114 RXLRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILA 233
R L AGL V++VS++TR PEM+ GRVKTLHPAVH G+LA
Sbjct: 92 RALTEAGLAVREVSELTRFPEMMDGRVKTLHPAVHGGLLA 131
Score = 53.2 bits (122), Expect = 4e-06
Identities = 45/131 (34%), Positives = 63/131 (48%), Gaps = 3/131 (2%)
Frame = +2
Query: 17 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERRPHSSRCVGHHEXTGDARRSGE 196
ALLSVSDKTGL A +LS+ G++L+++GGT +E + R V + G
Sbjct: 60 ALLSVSDKTGLTDFAAALSQRGVELVSTGGTHRALTE-AGLAVREVSELTRFPE-MMDGR 117
Query: 197 NFTSSGTCWDLSSIIRL*PED---MKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAVEN 367
T +R PE + I + NLYPF +T+ K D VEN
Sbjct: 118 VKTLHPAVHGGLLAVRDNPEHQAALAAHGIGAIDLLVVNLYPFEETL-KAGKAYDDCVEN 176
Query: 368 IDIGGVTLLRA 400
ID+GG ++RA
Sbjct: 177 IDVGGPAMIRA 187
>UniRef50_Q9RW01 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=3; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Deinococcus radiodurans
Length = 510
Score = 60.5 bits (140), Expect = 3e-08
Identities = 27/39 (69%), Positives = 31/39 (79%)
Frame = +3
Query: 120 LRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILAR 236
L AG+ V+ VSD+T PEML GRVKTLHPA+H GILAR
Sbjct: 39 LSGAGIPVRQVSDVTGFPEMLDGRVKTLHPAIHGGILAR 77
Score = 53.6 bits (123), Expect = 3e-06
Identities = 47/135 (34%), Positives = 66/135 (48%), Gaps = 5/135 (3%)
Frame = +2
Query: 11 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGT-ATXASERRP--HSSRCVGHHEXTGDA 181
K AL+SVSDKTG++ A L + G +L+++GGT AT + P S G E D
Sbjct: 3 KRALISVSDKTGVVEFAAQLQQRGWELLSTGGTFATLSGAGIPVRQVSDVTGFPEML-DG 61
Query: 182 RRSGENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSK--PDVTVAD 355
R + G L + Q I V NLYPF +TV++ PD +
Sbjct: 62 RVKTLHPAIHGGILARREAGHL--GQLAAQDIGTIDLVCVNLYPFRETVARGAPD---PE 116
Query: 356 AVENIDIGGVTLLRA 400
+ENIDIGG ++R+
Sbjct: 117 VIENIDIGGPAMIRS 131
>UniRef50_UPI00015BCE7E Cluster: UPI00015BCE7E related cluster; n=1;
unknown|Rep: UPI00015BCE7E UniRef100 entry - unknown
Length = 506
Score = 60.1 bits (139), Expect = 4e-08
Identities = 47/131 (35%), Positives = 63/131 (48%), Gaps = 3/131 (2%)
Frame = +2
Query: 17 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTAT---XASERRPHSSRCVGHHEXTGDARR 187
AL+SV DKTG+L LAK L G ++++SGGT T A S G E G +
Sbjct: 3 ALISVYDKTGILELAKELLNQGYEILSSGGTYTYLKNAGVDAIEVSEVTGFREILGGRVK 62
Query: 188 SGENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAVEN 367
+ G + + E++K E I V NLYPF + + K + VE
Sbjct: 63 TLHPAIHGGILF--REDVEKDLEEIKENSIEPIDIVVVNLYPFEKKM-KELKDIDALVEF 119
Query: 368 IDIGGVTLLRA 400
IDIGG TL+RA
Sbjct: 120 IDIGGPTLVRA 130
Score = 54.8 bits (126), Expect = 1e-06
Identities = 24/39 (61%), Positives = 31/39 (79%)
Frame = +3
Query: 120 LRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILAR 236
L+NAG+ +VS++T E+LGGRVKTLHPA+H GIL R
Sbjct: 37 LKNAGVDAIEVSEVTGFREILGGRVKTLHPAIHGGILFR 75
>UniRef50_A6G003 Cluster: Bifunctional
phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=1; Plesiocystis
pacifica SIR-1|Rep: Bifunctional
phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Plesiocystis
pacifica SIR-1
Length = 543
Score = 59.7 bits (138), Expect = 5e-08
Identities = 50/139 (35%), Positives = 73/139 (52%), Gaps = 6/139 (4%)
Frame = +2
Query: 2 AXXKLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERRPHSSRCVGHHEXTGDA 181
A + AL+SVSDK+ L LA+ L ++++++GGT SE V E TG
Sbjct: 12 APIRRALVSVSDKSKLDVLAEILIAHKVEVLSTGGTYRALSEL---GVAVVKVSEFTGAP 68
Query: 182 R-RSGENFTSSGTCWDLSSIIRL*PEDMKRQKYEM-----ISXVXCNLYPFVQTVSKPDV 343
G T I+ L P + +++ E+ I V NLYPF +T++KP
Sbjct: 69 EILDGRVKTLHPKIH--GGILAL-PTEAHQRELELHDIAPIDLVIVNLYPFRETIAKPGC 125
Query: 344 TVADAVENIDIGGVTLLRA 400
+ ADA+ENIDIGG T++RA
Sbjct: 126 SFADAIENIDIGGPTMVRA 144
Score = 52.0 bits (119), Expect = 1e-05
Identities = 24/48 (50%), Positives = 32/48 (66%)
Frame = +3
Query: 114 RXLRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILARLSDSDQK 257
R L G+ V VS+ T PE+L GRVKTLHP +H GILA +++ Q+
Sbjct: 49 RALSELGVAVVKVSEFTGAPEILDGRVKTLHPKIHGGILALPTEAHQR 96
>UniRef50_A0JTW4 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=2;
Arthrobacter|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Arthrobacter sp.
(strain FB24)
Length = 559
Score = 58.8 bits (136), Expect = 9e-08
Identities = 45/131 (34%), Positives = 62/131 (47%), Gaps = 3/131 (2%)
Frame = +2
Query: 17 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTA-TXASERRP--HSSRCVGHHEXTGDARR 187
AL+SV DKTGL LAK L E G++++++G TA A+ P G E +
Sbjct: 14 ALISVYDKTGLEELAKGLHEAGVKIVSTGSTAKKIAAAGIPVQEVEEVTGSPEMLDGRVK 73
Query: 188 SGENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAVEN 367
+ G D + E + + E V NLYPFV+TV K D VE
Sbjct: 74 TLHPRVHGGILADRRVPAHM--ETLAGMEIEAFDLVVVNLYPFVETV-KSGAAQDDVVEQ 130
Query: 368 IDIGGVTLLRA 400
IDIGG ++R+
Sbjct: 131 IDIGGPAMVRS 141
Score = 54.8 bits (126), Expect = 1e-06
Identities = 24/35 (68%), Positives = 28/35 (80%)
Frame = +3
Query: 129 AGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILA 233
AG+ VQ+V ++T PEML GRVKTLHP VH GILA
Sbjct: 51 AGIPVQEVEEVTGSPEMLDGRVKTLHPRVHGGILA 85
>UniRef50_Q7X311 Cluster: Putative AICAR transformylase; n=1;
uncultured Acidobacteria bacterium|Rep: Putative AICAR
transformylase - uncultured Acidobacteria bacterium
Length = 571
Score = 58.4 bits (135), Expect = 1e-07
Identities = 24/39 (61%), Positives = 31/39 (79%)
Frame = +3
Query: 114 RXLRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGIL 230
+ LR AG+ V+DVSD+T PEM+ GRVKTLHP +H G+L
Sbjct: 47 KTLREAGIEVRDVSDVTGFPEMMDGRVKTLHPKIHGGLL 85
Score = 57.2 bits (132), Expect = 3e-07
Identities = 40/131 (30%), Positives = 62/131 (47%), Gaps = 3/131 (2%)
Frame = +2
Query: 17 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERRPHS---SRCVGHHEXTGDARR 187
AL+SVSDKTG++ A L ++++++GGTA E S G E +
Sbjct: 15 ALISVSDKTGIVDFASELRAFDIEIVSTGGTAKTLREAGIEVRDVSDVTGFPEMMDGRVK 74
Query: 188 SGENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAVEN 367
+ G S M+ E I V +LYPF +T+ V++A+A+E
Sbjct: 75 TLHPKIHGGLLGVRDSPSH--ESSMREHGIEPIDMVVIDLYPFERTIKGAAVSLAEAIEQ 132
Query: 368 IDIGGVTLLRA 400
IDIGG ++R+
Sbjct: 133 IDIGGPAMIRS 143
>UniRef50_Q9FPL3 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=14;
Viridiplantae|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Nicotiana tabacum
(Common tobacco)
Length = 612
Score = 58.4 bits (135), Expect = 1e-07
Identities = 26/39 (66%), Positives = 31/39 (79%)
Frame = +3
Query: 120 LRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILAR 236
L AG++V V ++TR PEML GRVKTLHP+VH GILAR
Sbjct: 125 LEGAGVSVTKVEELTRFPEMLDGRVKTLHPSVHGGILAR 163
Score = 49.6 bits (113), Expect = 5e-05
Identities = 38/134 (28%), Positives = 58/134 (43%), Gaps = 4/134 (2%)
Frame = +2
Query: 11 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATX---ASERRPHSSRCVGHHEXTGDA 181
K AL+S+SDKT L L L E G ++++GGT++ A E
Sbjct: 89 KQALISLSDKTDLAKLGNGLQELGYTIVSTGGTSSALEGAGVSVTKVEELTRFPEMLDGR 148
Query: 182 RRSGENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPD-VTVADA 358
++ G + E +++ + V NLYPF VS ++ D
Sbjct: 149 VKTLHPSVHGGILARRDQEHHM--EALEKHEIGTFDVVVVNLYPFYAKVSSSSGISFEDG 206
Query: 359 VENIDIGGVTLLRA 400
+ENIDIGG ++RA
Sbjct: 207 IENIDIGGPAMIRA 220
>UniRef50_A2SS05 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=3;
Methanomicrobiales|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase -
Methanocorpusculum labreanum (strain ATCC 43576 / DSM
4855 / Z)
Length = 497
Score = 57.6 bits (133), Expect = 2e-07
Identities = 25/46 (54%), Positives = 32/46 (69%)
Frame = +3
Query: 114 RXLRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILARLSDSD 251
+ LR AG+ +DVS+ T+ PEM+ GRVKTLHP VH G+L R D
Sbjct: 36 KALREAGIPAKDVSEYTQFPEMMDGRVKTLHPKVHGGLLGRRGIDD 81
Score = 54.4 bits (125), Expect = 2e-06
Identities = 41/129 (31%), Positives = 64/129 (49%)
Frame = +2
Query: 14 LALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERRPHSSRCVGHHEXTGDARRSG 193
LALLSV DKTG+L LA++L + +++SGGTA A ++ V + +
Sbjct: 3 LALLSVWDKTGILDLARALVAKNIGILSSGGTA-KALREAGIPAKDVSEYTQFPEMMDGR 61
Query: 194 ENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAVENID 373
L + + MK E I + NLYPF + +SK ++ + + +E ID
Sbjct: 62 VKTLHPKVHGGLLGRRGIDDDVMKAHFIEPIDILCVNLYPF-EEMSKKNLPLEELIEFID 120
Query: 374 IGGVTLLRA 400
IGG ++RA
Sbjct: 121 IGGPAMIRA 129
>UniRef50_Q1V178 Cluster: Bifunctional purine biosynthesis protein;
n=2; Candidatus Pelagibacter ubique|Rep: Bifunctional
purine biosynthesis protein - Candidatus Pelagibacter
ubique HTCC1002
Length = 518
Score = 56.4 bits (130), Expect = 5e-07
Identities = 41/133 (30%), Positives = 68/133 (51%), Gaps = 3/133 (2%)
Frame = +2
Query: 11 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERR---PHSSRCVGHHEXTGDA 181
K AL+SVSDK L SL + L++ ++LI+SGGT + + S G E G
Sbjct: 12 KKALISVSDKKDLGSLLRVLAKYKIELISSGGTFKEIKKLKFKCQEVSEYTGSPEILGGR 71
Query: 182 RRSGENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAV 361
++ +G + + +++K +Y+ I V N YPF +T+ + + +
Sbjct: 72 VKTLHPKIHAGILSKRND--KSHTKELKANQYDEIDLVIVNFYPFEKTLDQT-TNHSKII 128
Query: 362 ENIDIGGVTLLRA 400
ENID+GG T++RA
Sbjct: 129 ENIDVGGPTMVRA 141
Score = 52.8 bits (121), Expect = 6e-06
Identities = 22/34 (64%), Positives = 29/34 (85%)
Frame = +3
Query: 144 QDVSDITRXPEMLGGRVKTLHPAVHAGILARLSD 245
Q+VS+ T PE+LGGRVKTLHP +HAGIL++ +D
Sbjct: 56 QEVSEYTGSPEILGGRVKTLHPKIHAGILSKRND 89
>UniRef50_A1IEQ8 Cluster: IMP cyclohydrolase; n=1; Candidatus
Desulfococcus oleovorans Hxd3|Rep: IMP cyclohydrolase -
Candidatus Desulfococcus oleovorans Hxd3
Length = 225
Score = 56.0 bits (129), Expect = 6e-07
Identities = 47/138 (34%), Positives = 63/138 (45%), Gaps = 8/138 (5%)
Frame = +2
Query: 20 LLSVSDKTGLLSLAKSLSECG--LQLIASGGTATXASERRPHSSRCVGHH--EXTGDARR 187
L+SVSDKTGL L + + ++GGT E +++ V + TG
Sbjct: 19 LISVSDKTGLEEFVTRLVRINPDVHIFSTGGTYQKIYEIFGSAAKSVLTQVSDYTGQPET 78
Query: 188 SGENFTSSGTCWDLSSIIRL*PE----DMKRQKYEMISXVXCNLYPFVQTVSKPDVTVAD 355
G + L + E DMKR I V NLYPF QTV++PDVT
Sbjct: 79 QGGLVKTLDFKIYLGLLTETYNESHARDMKRTGAVAIDMVVVNLYPFSQTVARPDVTPEQ 138
Query: 356 AVENIDIGGVTLLRAQPR 409
A NIDIGG ++RA +
Sbjct: 139 ARGNIDIGGPCMVRASAK 156
>UniRef50_O67775 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=9; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Aquifex aeolicus
Length = 506
Score = 56.0 bits (129), Expect = 6e-07
Identities = 41/131 (31%), Positives = 65/131 (49%), Gaps = 3/131 (2%)
Frame = +2
Query: 17 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERR---PHSSRCVGHHEXTGDARR 187
A++SV K G+ LAK+L E G +++++GGTA E+ S G E +
Sbjct: 3 AIISVYRKEGIDKLAKALQELGYEIVSTGGTAKYLREKGISVKEVSEITGFPEILEGRVK 62
Query: 188 SGENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAVEN 367
+ G + + E++++ + I V NLYPF + + K +T D +E
Sbjct: 63 TLHPVVHGGILF--RDWVEKDKEEIEKHGIKPIDVVVVNLYPFEEKL-KEGLTDKDLMEF 119
Query: 368 IDIGGVTLLRA 400
IDIGG TL+RA
Sbjct: 120 IDIGGPTLIRA 130
Score = 56.0 bits (129), Expect = 6e-07
Identities = 25/41 (60%), Positives = 32/41 (78%)
Frame = +3
Query: 114 RXLRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILAR 236
+ LR G++V++VS+IT PE+L GRVKTLHP VH GIL R
Sbjct: 35 KYLREKGISVKEVSEITGFPEILEGRVKTLHPVVHGGILFR 75
>UniRef50_Q8XMK2 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=14; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Clostridium perfringens
Length = 501
Score = 55.2 bits (127), Expect = 1e-06
Identities = 42/133 (31%), Positives = 65/133 (48%), Gaps = 3/133 (2%)
Frame = +2
Query: 11 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERR---PHSSRCVGHHEXTGDA 181
K AL+SV DK G+L LAK L + +++I+SGGT E S E
Sbjct: 3 KRALISVFDKDGVLELAKFLRDRDVEIISSGGTYKYLKENNIEVKEISEITDFPEMLDGR 62
Query: 182 RRSGENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAV 361
++ +G + + + ++ ++ I V NLYPF + V + D++ + V
Sbjct: 63 VKTLHPLVHAGILAIRDNKEHM--KTLEEREINTIDYVVVNLYPFFEKV-REDLSFEEKV 119
Query: 362 ENIDIGGVTLLRA 400
E IDIGG T+LRA
Sbjct: 120 EFIDIGGPTMLRA 132
Score = 54.4 bits (125), Expect = 2e-06
Identities = 24/40 (60%), Positives = 31/40 (77%)
Frame = +3
Query: 114 RXLRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILA 233
+ L+ + V+++S+IT PEML GRVKTLHP VHAGILA
Sbjct: 37 KYLKENNIEVKEISEITDFPEMLDGRVKTLHPLVHAGILA 76
>UniRef50_Q316G8 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=4; Desulfovibrionaceae|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Desulfovibrio desulfuricans (strain
G20)
Length = 252
Score = 54.8 bits (126), Expect = 1e-06
Identities = 25/40 (62%), Positives = 29/40 (72%)
Frame = +3
Query: 114 RXLRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILA 233
R L AGL V VS +T PE++GGRVKTLHP +H GILA
Sbjct: 94 RTLTEAGLDVTPVSKVTGFPEIMGGRVKTLHPHIHGGILA 133
Score = 52.4 bits (120), Expect = 8e-06
Identities = 40/131 (30%), Positives = 62/131 (47%), Gaps = 3/131 (2%)
Frame = +2
Query: 17 ALLSVSDKTGLLSLAKSLSECGLQLIASGG---TATXASERRPHSSRCVGHHEXTGDARR 187
ALLSV+DK+GL+ A L++ G++L+++GG T T A S+ G E G +
Sbjct: 62 ALLSVTDKSGLVEFATFLTQNGVELVSTGGTQRTLTEAGLDVTPVSKVTGFPEIMGGRVK 121
Query: 188 SGENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAVEN 367
+ G D + L +K + NLY F ++ + + AVE
Sbjct: 122 TLHPHIHGGILADKDNPEHL--ATLKELGIRTFDLICVNLYNFADAAAR-GLDLRGAVEE 178
Query: 368 IDIGGVTLLRA 400
+DIGG +LRA
Sbjct: 179 VDIGGPCMLRA 189
>UniRef50_Q8G6B1 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=89; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Bifidobacterium longum
Length = 545
Score = 54.4 bits (125), Expect = 2e-06
Identities = 24/46 (52%), Positives = 33/46 (71%)
Frame = +3
Query: 114 RXLRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILARLSDSD 251
+ L G+ V +VSD+T PE L GRVKTLHP +HAGILA +++ +
Sbjct: 43 KKLAELGVKVTEVSDVTGFPECLDGRVKTLHPYIHAGILADMTNPE 88
Score = 48.4 bits (110), Expect = 1e-04
Identities = 38/133 (28%), Positives = 65/133 (48%), Gaps = 6/133 (4%)
Frame = +2
Query: 17 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASE---RRPHSSRCVGHHEXTGDARR 187
AL+SV K G+ LA++ + G +++++G TA +E + S G E +
Sbjct: 11 ALVSVFHKEGIEVLAEAFVKAGTEVVSTGSTAKKLAELGVKVTEVSDVTGFPECLDGRVK 70
Query: 188 SGENFTSSGTCWDLSSIIRL*PEDMKRQK---YEMISXVXCNLYPFVQTVSKPDVTVADA 358
+ + +G D+++ PE K+ + + V NLYPF TV + AD
Sbjct: 71 TLHPYIHAGILADMTN-----PEHAKQLEEFGIKPFDLVVVNLYPFADTV-RSGANEADT 124
Query: 359 VENIDIGGVTLLR 397
+E IDIGG +++R
Sbjct: 125 IEKIDIGGPSMVR 137
>UniRef50_Q9PNY2 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=21; Epsilonproteobacteria|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Campylobacter jejuni
Length = 510
Score = 54.0 bits (124), Expect = 3e-06
Identities = 23/46 (50%), Positives = 32/46 (69%)
Frame = +3
Query: 114 RXLRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILARLSDSD 251
+ L+ G+ V +VSD T+ PE+ GRVKTLHP +H GIL + SD +
Sbjct: 35 KLLKENGIKVIEVSDFTKSPELFEGRVKTLHPKIHGGILHKRSDEN 80
Score = 45.6 bits (103), Expect = 9e-04
Identities = 38/131 (29%), Positives = 57/131 (43%), Gaps = 3/131 (2%)
Frame = +2
Query: 17 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASE---RRPHSSRCVGHHEXTGDARR 187
ALLSVSDK G++ K L G +++++GGT E + S E +
Sbjct: 3 ALLSVSDKEGIVEFGKELENLGFEILSTGGTFKLLKENGIKVIEVSDFTKSPELFEGRVK 62
Query: 188 SGENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAVEN 367
+ G S + + K + I V NLYPF +T D + +EN
Sbjct: 63 TLHPKIHGGILHKRSDENHI--KQAKENEILGIDLVCVNLYPFKKTTIMSD-DFDEIIEN 119
Query: 368 IDIGGVTLLRA 400
IDIGG ++R+
Sbjct: 120 IDIGGPAMIRS 130
Score = 34.3 bits (75), Expect = 2.2
Identities = 12/30 (40%), Positives = 22/30 (73%)
Frame = +1
Query: 403 AKNHDRVTVVCDPADYDAVVKXIKENKHHQ 492
AKN+ V V+CDP DY+ V++ +K+ ++ +
Sbjct: 132 AKNYKDVMVLCDPLDYEKVIETLKKGQNDE 161
>UniRef50_Q83GZ1 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=2; Tropheryma whipplei|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Tropheryma whipplei (strain Twist)
(Whipple's bacillus)
Length = 542
Score = 52.4 bits (120), Expect = 8e-06
Identities = 39/139 (28%), Positives = 66/139 (47%), Gaps = 3/139 (2%)
Frame = +2
Query: 11 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATX---ASERRPHSSRCVGHHEXTGDA 181
K AL+SVSDK+GL LA++L+ ++++++G TA S S G E
Sbjct: 8 KRALISVSDKSGLADLAEALAAHSVKIVSTGSTAEFIRGVSIPVRDVSEVTGVGELLDGR 67
Query: 182 RRSGENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAV 361
++ + D +S ++ +++ + V NLYPF + + +D +
Sbjct: 68 VKTLHPKIHAPILADTTS--QMHRAQLQQLGVDAFDLVVVNLYPFFEISKNSEAEFSDVI 125
Query: 362 ENIDIGGVTLLRAQPRTTT 418
E IDIGG L+RA + T
Sbjct: 126 EQIDIGGSALIRAAAKNHT 144
Score = 48.4 bits (110), Expect = 1e-04
Identities = 21/38 (55%), Positives = 28/38 (73%)
Frame = +3
Query: 120 LRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILA 233
+R + V+DVS++T E+L GRVKTLHP +HA ILA
Sbjct: 44 IRGVSIPVRDVSEVTGVGELLDGRVKTLHPKIHAPILA 81
>UniRef50_Q7VRP9 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase, IMP cyclohydrolase and MGS-like
domain; n=2; Candidatus Blochmannia|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase, IMP cyclohydrolase and MGS-like
domain - Blochmannia floridanus
Length = 549
Score = 50.8 bits (116), Expect = 2e-05
Identities = 23/39 (58%), Positives = 29/39 (74%)
Frame = +3
Query: 120 LRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILAR 236
L NAGLTV +SD T PE++ G+VKTLH + AGIL+R
Sbjct: 44 LTNAGLTVNKISDYTNFPEIMNGQVKTLHHKICAGILSR 82
Score = 44.8 bits (101), Expect = 0.002
Identities = 34/128 (26%), Positives = 56/128 (43%)
Frame = +2
Query: 17 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERRPHSSRCVGHHEXTGDARRSGE 196
AL+SV DK+ LL +KSLS G++L+++ GTA + ++ + + +
Sbjct: 10 ALISVFDKSNLLHFSKSLSHLGIKLLSTEGTALILTNAGLTVNK-ISDYTNFPEIMNGQV 68
Query: 197 NFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAVENIDI 376
C + S L + + + I V N YPF + +E IDI
Sbjct: 69 KTLHHKICAGILSRKNLDESIIHKYGIQPIDMVIVNFYPFHLILQNKQHDSEKILEYIDI 128
Query: 377 GGVTLLRA 400
GG ++RA
Sbjct: 129 GGPNMVRA 136
>UniRef50_Q7MUT5 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=24;
Bacteria|Rep: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Porphyromonas
gingivalis (Bacteroides gingivalis)
Length = 508
Score = 50.4 bits (115), Expect = 3e-05
Identities = 22/39 (56%), Positives = 27/39 (69%)
Frame = +3
Query: 120 LRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILAR 236
+ + G + V D+TR P MLGGRVKTLHP + GILAR
Sbjct: 45 ITSLGYACRAVDDLTRYPSMLGGRVKTLHPMIFGGILAR 83
Score = 39.1 bits (87), Expect = 0.078
Identities = 37/131 (28%), Positives = 60/131 (45%), Gaps = 4/131 (3%)
Frame = +2
Query: 17 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERRPHSSRCVGHHEXTGDARRSGE 196
AL+SV K GL + L+ G++ +++GGT + ++ R V + T G
Sbjct: 11 ALISVYHKEGLAEILAELNRQGVEFVSTGGTHEFITSLG-YACRAVD--DLTRYPSMLGG 67
Query: 197 NFTSSGTCWDLSSIIRL*PEDMKRQKYE----MISXVXCNLYPFVQTVSKPDVTVADAVE 364
+ + R E R+ E +I V +LYPF TV+ + D +E
Sbjct: 68 RVKTLHPMIFGGILARRGHESDVREVGEYGLPLIDLVIVDLYPFEATVAS-GASEEDIIE 126
Query: 365 NIDIGGVTLLR 397
IDIGG++L+R
Sbjct: 127 KIDIGGISLIR 137
>UniRef50_A7I7L2 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=1; Candidatus
Methanoregula boonei 6A8|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Methanoregula
boonei (strain 6A8)
Length = 525
Score = 50.0 bits (114), Expect = 4e-05
Identities = 41/133 (30%), Positives = 65/133 (48%), Gaps = 3/133 (2%)
Frame = +2
Query: 11 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTAT-XASERRPHS--SRCVGHHEXTGDA 181
K ALLSV DKTG++ LA++L + +++SGGT T A P + SR G E
Sbjct: 32 KWALLSVWDKTGIVDLAQALIQHNFSIMSSGGTGTALAGAGIPFTEVSRYTGFPEMMDGR 91
Query: 182 RRSGENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAV 361
++ G L ++ M + I + NLYPF + +S+ + + +
Sbjct: 92 VKTLHPKVHGG----LLGRRQIDDAIMAKYGINRIGLLVVNLYPF-ERMSRESLPLEKLI 146
Query: 362 ENIDIGGVTLLRA 400
E ID+GG ++RA
Sbjct: 147 EYIDVGGPAMIRA 159
Score = 49.2 bits (112), Expect = 7e-05
Identities = 23/44 (52%), Positives = 27/44 (61%)
Frame = +3
Query: 120 LRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILARLSDSD 251
L AG+ +VS T PEM+ GRVKTLHP VH G+L R D
Sbjct: 68 LAGAGIPFTEVSRYTGFPEMMDGRVKTLHPKVHGGLLGRRQIDD 111
>UniRef50_Q6L122 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=4; Thermoplasmatales|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Picrophilus torridus
Length = 494
Score = 49.2 bits (112), Expect = 7e-05
Identities = 21/47 (44%), Positives = 33/47 (70%)
Frame = +3
Query: 114 RXLRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILARLSDSDQ 254
+ L ++G+ + +SDIT ++L GRVKTLHPAV +GIL+R + +
Sbjct: 32 KFLSDSGIKAKRISDITGFDDLLNGRVKTLHPAVFSGILSRRDEQSE 78
Score = 47.2 bits (107), Expect = 3e-04
Identities = 43/130 (33%), Positives = 62/130 (47%), Gaps = 3/130 (2%)
Frame = +2
Query: 20 LLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERRPHSSRCVGHHEXTG-DARRSGE 196
L+SVSD +GL L + L+ + A+ GT S+ + R + TG D +G
Sbjct: 4 LVSVSDTSGLTDLLRHLNG---DVYATPGTFKFLSDSGIKAKRI---SDITGFDDLLNGR 57
Query: 197 NFTSSGTCWD--LSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAVENI 370
T + LS D+KR Y V CNLY F + K ++ D +ENI
Sbjct: 58 VKTLHPAVFSGILSRRDEQSEADLKRYNYFDFDIVICNLYNFESYIDK---SIEDMIENI 114
Query: 371 DIGGVTLLRA 400
DIGG++L+RA
Sbjct: 115 DIGGLSLIRA 124
>UniRef50_Q89B23 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=2; Buchnera aphidicola (Baizongia
pistaciae)|Rep: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Buchnera aphidicola subsp.
Baizongia pistaciae
Length = 529
Score = 48.4 bits (110), Expect = 1e-04
Identities = 37/133 (27%), Positives = 65/133 (48%), Gaps = 3/133 (2%)
Frame = +2
Query: 11 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERRPHSSRCVGHHEXTGDARRS 190
K L+SVSD + ++ +KSL ++L A+ GTA + +++ + +
Sbjct: 8 KNVLISVSDTSNIIEFSKSLISKNIKLFATKGTANFLKKNNIYATDITNYTNFP--EIMN 65
Query: 191 GENFTSSGTCWDLSSIIRL*PEDMKR-QKYEMI--SXVXCNLYPFVQTVSKPDVTVADAV 361
G T + +SI+ D K +KY +I V N YPF + + ++ + D +
Sbjct: 66 GRIKTLHHKIY--ASILAQPKHDKKTIEKYNIILMDIVVINFYPFEEASNNTNLHLNDII 123
Query: 362 ENIDIGGVTLLRA 400
E+IDIGG ++RA
Sbjct: 124 EHIDIGGPAIVRA 136
Score = 40.3 bits (90), Expect = 0.034
Identities = 18/47 (38%), Positives = 30/47 (63%)
Frame = +3
Query: 120 LRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILARLSDSDQKT 260
L+ + D+++ T PE++ GR+KTLH ++A ILA+ D+KT
Sbjct: 44 LKKNNIYATDITNYTNFPEIMNGRIKTLHHKIYASILAQ-PKHDKKT 89
>UniRef50_A4MAE3 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=1; Petrotoga mobilis SJ95|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Petrotoga mobilis SJ95
Length = 489
Score = 47.6 bits (108), Expect = 2e-04
Identities = 41/133 (30%), Positives = 62/133 (46%), Gaps = 3/133 (2%)
Frame = +2
Query: 11 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERRPHSSRC---VGHHEXTGDA 181
K A++SV DKT L LA L G+++I + GT E+ + + +G E G
Sbjct: 4 KRAIISVYDKTNLEDLASFLYRNGVEIICTEGTNKYLQEKGIPTVKMADYIGFPEILGGR 63
Query: 182 RRSGENFTSSGTCWDLSSIIRL*PEDMKRQKYEMISXVXCNLYPFVQTVSKPDVTVADAV 361
+S + + G S + EDM + I V N +P + ++K +
Sbjct: 64 VKSIDPKLAGGIL--AKSNDKKHEEDMINYNIKRIDMVVGN-FPTFEEIAKKTKNEETLL 120
Query: 362 ENIDIGGVTLLRA 400
ENIDIGG +LLRA
Sbjct: 121 ENIDIGGYSLLRA 133
Score = 39.1 bits (87), Expect = 0.078
Identities = 17/44 (38%), Positives = 28/44 (63%)
Frame = +3
Query: 114 RXLRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILARLSD 245
+ L+ G+ ++D PE+LGGRVK++ P + GILA+ +D
Sbjct: 38 KYLQEKGIPTVKMADYIGFPEILGGRVKSIDPKLAGGILAKSND 81
>UniRef50_Q8A155 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=5; Bacteroides|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Bacteroides thetaiotaomicron
Length = 507
Score = 47.6 bits (108), Expect = 2e-04
Identities = 43/133 (32%), Positives = 67/133 (50%), Gaps = 3/133 (2%)
Frame = +2
Query: 11 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERRPHSSRCVGHHEXTGDARRS 190
K AL+SV K GL + L E G++ +++GGT E + + V T +
Sbjct: 8 KTALVSVYHKEGLDEIITKLYEEGVEFLSTGGTRQFI-ESLGYPCKAV-EDLTTYPSILG 65
Query: 191 GENFTSSGTCWDLSSIIRL*PEDMKR-QKYEM--ISXVXCNLYPFVQTVSKPDVTVADAV 361
G T + R +D+++ +KYE+ I V +LYPF TV+ + AD +
Sbjct: 66 GRVKTLHPKIFGGILCRRDLEQDIQQIEKYEIPEIDLVIVDLYPFEATVAS-GASEADII 124
Query: 362 ENIDIGGVTLLRA 400
E IDIGG++L+RA
Sbjct: 125 EKIDIGGISLIRA 137
Score = 44.8 bits (101), Expect = 0.002
Identities = 19/39 (48%), Positives = 25/39 (64%)
Frame = +3
Query: 120 LRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILAR 236
+ + G + V D+T P +LGGRVKTLHP + GIL R
Sbjct: 44 IESLGYPCKAVEDLTTYPSILGGRVKTLHPKIFGGILCR 82
>UniRef50_A1G3C3 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=1; Salinispora arenicola
CNS205|Rep: Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Salinispora arenicola CNS205
Length = 190
Score = 46.8 bits (106), Expect = 4e-04
Identities = 24/47 (51%), Positives = 32/47 (68%)
Frame = +3
Query: 114 RXLRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILARLSDSDQ 254
R LR+ G+TV VSD+ P +LGGRVKTL ++ GILAR +D+
Sbjct: 35 RLLRDHGVTVGAVSDLAGVPTLLGGRVKTLTVSLMGGILARDEPADR 81
>UniRef50_Q9X0X6 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=4; Thermotogaceae|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Thermotoga maritima
Length = 452
Score = 44.0 bits (99), Expect = 0.003
Identities = 20/39 (51%), Positives = 26/39 (66%)
Frame = +3
Query: 114 RXLRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGIL 230
+ L++ G+ DVS IT +LGG VKTLHP + AGIL
Sbjct: 36 KFLKSNGIEANDVSTITGFENLLGGLVKTLHPEIFAGIL 74
>UniRef50_Q3JNS9 Cluster: Putative uncharacterized protein; n=9;
Burkholderia|Rep: Putative uncharacterized protein -
Burkholderia pseudomallei (strain 1710b)
Length = 917
Score = 41.1 bits (92), Expect = 0.019
Identities = 22/32 (68%), Positives = 23/32 (71%)
Frame = -2
Query: 397 AQEGHAADVDVLDRVRXGHVRLRYRLDERVQV 302
AQ AADVDVLDRV V LR RLDER+QV
Sbjct: 723 AQHRRAADVDVLDRVGERAVVLRNRLDERIQV 754
>UniRef50_A7PK27 Cluster: Chromosome chr15 scaffold_19, whole genome
shotgun sequence; n=1; Vitis vinifera|Rep: Chromosome
chr15 scaffold_19, whole genome shotgun sequence - Vitis
vinifera (Grape)
Length = 227
Score = 39.9 bits (89), Expect = 0.044
Identities = 18/39 (46%), Positives = 24/39 (61%)
Frame = +3
Query: 120 LRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILAR 236
L NA ++ V +T P++L G VKTLHP + GIL R
Sbjct: 58 LENAWVSTTKVEQLTCFPKILDGHVKTLHPNIQGGILPR 96
>UniRef50_A5B1A5 Cluster: DNA-directed RNA polymerase; n=1; Vitis
vinifera|Rep: DNA-directed RNA polymerase - Vitis
vinifera (Grape)
Length = 202
Score = 39.9 bits (89), Expect = 0.044
Identities = 18/39 (46%), Positives = 24/39 (61%)
Frame = +3
Query: 120 LRNAGLTVQDVSDITRXPEMLGGRVKTLHPAVHAGILAR 236
L NA ++ V +T P++L G VKTLHP + GIL R
Sbjct: 58 LENAWVSTTKVEQLTCFPKILDGHVKTLHPNIQGGILPR 96
>UniRef50_A5B3D8 Cluster: DNA-directed RNA polymerase; n=1; Vitis
vinifera|Rep: DNA-directed RNA polymerase - Vitis
vinifera (Grape)
Length = 153
Score = 35.9 bits (79), Expect = 0.72
Identities = 15/20 (75%), Positives = 16/20 (80%)
Frame = +3
Query: 177 MLGGRVKTLHPAVHAGILAR 236
ML G VKTLHP +H GILAR
Sbjct: 1 MLDGHVKTLHPNIHGGILAR 20
>UniRef50_A1HBX2 Cluster: Putative uncharacterized protein; n=2;
Ralstonia pickettii|Rep: Putative uncharacterized
protein - Ralstonia pickettii 12J
Length = 699
Score = 34.7 bits (76), Expect = 1.7
Identities = 20/32 (62%), Positives = 21/32 (65%)
Frame = -2
Query: 397 AQEGHAADVDVLDRVRXGHVRLRYRLDERVQV 302
AQ G AADVDVLD V L +RL ERVQV
Sbjct: 434 AQHGRAADVDVLDGVGQRAFVLGHRLLERVQV 465
>UniRef50_A4M1L4 Cluster: Putative uncharacterized protein; n=1;
Geobacter bemidjiensis Bem|Rep: Putative uncharacterized
protein - Geobacter bemidjiensis Bem
Length = 546
Score = 34.3 bits (75), Expect = 2.2
Identities = 19/47 (40%), Positives = 25/47 (53%)
Frame = -2
Query: 397 AQEGHAADVDVLDRVRXGHVRLRYRLDERVQVTXHXAYHLVLLTFHV 257
A+ G AAD+DVLD + G V R ERV+V H L + H+
Sbjct: 412 AEHGRAADIDVLDGILHGAVLFRDGRLERVEVYHHHVDGLDAVLLHL 458
>UniRef50_UPI0000382898 Cluster: COG0138: AICAR transformylase/IMP
cyclohydrolase PurH (only IMP cyclohydrolase domain in
Aful); n=1; Magnetospirillum magnetotacticum MS-1|Rep:
COG0138: AICAR transformylase/IMP cyclohydrolase PurH
(only IMP cyclohydrolase domain in Aful) -
Magnetospirillum magnetotacticum MS-1
Length = 50
Score = 33.1 bits (72), Expect = 5.1
Identities = 17/45 (37%), Positives = 24/45 (53%)
Frame = +2
Query: 17 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASERRPHSSRC 151
ALLSVSDKTGL A +L G++L+++ S +C
Sbjct: 4 ALLSVSDKTGLTDFAAALIGQGVELVSTAAPIARXHRAGLRSGKC 48
>UniRef50_Q01GS0 Cluster: Chromosome 01 contig 1, DNA sequence; n=1;
Ostreococcus tauri|Rep: Chromosome 01 contig 1, DNA
sequence - Ostreococcus tauri
Length = 489
Score = 32.7 bits (71), Expect = 6.7
Identities = 17/46 (36%), Positives = 26/46 (56%)
Frame = +2
Query: 80 GLQLIASGGTATXASERRPHSSRCVGHHEXTGDARRSGENFTSSGT 217
G + A T++ ASERR +R +GHH G+A GE+ ++ T
Sbjct: 355 GHDVFAPRATSSIASERR---ARAIGHHTLAGEAPDEGESAVTTRT 397
>UniRef50_O28464 Cluster: Inosine monophosphate cyclohydrolase; n=1;
Archaeoglobus fulgidus|Rep: Inosine monophosphate
cyclohydrolase - Archaeoglobus fulgidus
Length = 157
Score = 32.7 bits (71), Expect = 6.7
Identities = 16/37 (43%), Positives = 24/37 (64%)
Frame = +2
Query: 20 LLSVSDKTGLLSLAKSLSECGLQLIASGGTATXASER 130
L+S S K G+ LAK L+E G +++A+ GTA E+
Sbjct: 4 LISSSVKEGIECLAKRLAEMGYEILATEGTADYLQEK 40
>UniRef50_O67501 Cluster: Inorganic pyrophosphatase; n=37;
Bacteria|Rep: Inorganic pyrophosphatase - Aquifex
aeolicus
Length = 178
Score = 32.7 bits (71), Expect = 6.7
Identities = 15/39 (38%), Positives = 21/39 (53%)
Frame = -3
Query: 495 RLMMFVLFDXFDYSIVVGRVTDDGDPVVVLGCARRRVTP 379
R + ++ F+Y V + DDGDPV VL +R V P
Sbjct: 43 RFLFTAMYYPFNYGFVPQTLADDGDPVDVLVISREPVVP 81
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 511,376,633
Number of Sequences: 1657284
Number of extensions: 8840414
Number of successful extensions: 27295
Number of sequences better than 10.0: 58
Number of HSP's better than 10.0 without gapping: 26287
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 27263
length of database: 575,637,011
effective HSP length: 97
effective length of database: 414,880,463
effective search space used: 41902926763
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
- SilkBase 1999-2023 -