Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fbpv0106
(687 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q4SHT8 Cluster: Chromosome 5 SCAF14581, whole genome sh... 103 4e-21
UniRef50_P31939 Cluster: Bifunctional purine biosynthesis protei... 97 4e-19
UniRef50_P74741 Cluster: Bifunctional purine biosynthesis protei... 80 4e-14
UniRef50_Q73LG8 Cluster: Phosphoribosylaminoimidazolecarboxamide... 79 1e-13
UniRef50_P43852 Cluster: Bifunctional purine biosynthesis protei... 78 2e-13
UniRef50_Q2JI00 Cluster: Bifunctional purine biosynthesis protei... 78 2e-13
UniRef50_P67543 Cluster: Bifunctional purine biosynthesis protei... 77 3e-13
UniRef50_Q8ZAR3 Cluster: Bifunctional purine biosynthesis protei... 77 5e-13
UniRef50_Q2JR47 Cluster: Bifunctional purine biosynthesis protei... 76 7e-13
UniRef50_P12048 Cluster: Bifunctional purine biosynthesis protei... 75 2e-12
UniRef50_A1K9K5 Cluster: Phosphoribosylaminoimidazolecarboxamide... 75 2e-12
UniRef50_Q9F1T4 Cluster: Bifunctional purine biosynthesis protei... 75 2e-12
UniRef50_A5E8X1 Cluster: Phosphoribosylaminoimidazolecarboxamide... 73 5e-12
UniRef50_Q8PYG4 Cluster: Formyltransferase phosphoribosylaminoim... 73 9e-12
UniRef50_Q8CXK7 Cluster: Bifunctional purine biosynthesis protei... 71 3e-11
UniRef50_Q8F3W6 Cluster: Bifunctional purine biosynthesis protei... 70 5e-11
UniRef50_UPI00015BCE7E Cluster: UPI00015BCE7E related cluster; n... 69 1e-10
UniRef50_Q6MIZ2 Cluster: IMP cyclohydrolase; n=1; Bdellovibrio b... 69 1e-10
UniRef50_Q1V178 Cluster: Bifunctional purine biosynthesis protei... 69 1e-10
UniRef50_Q550I9 Cluster: AICAR transformylase / IMP cyclohydrola... 68 2e-10
UniRef50_Q9PC10 Cluster: Bifunctional purine biosynthesis protei... 67 3e-10
UniRef50_A7HM64 Cluster: IMP cyclohydrolase; n=1; Fervidobacteri... 66 6e-10
UniRef50_Q9FPL3 Cluster: Phosphoribosylaminoimidazolecarboxamide... 66 6e-10
UniRef50_A6G003 Cluster: Bifunctional phosphoribosylaminoimidazo... 65 1e-09
UniRef50_Q9RW01 Cluster: Bifunctional purine biosynthesis protei... 62 9e-09
UniRef50_A7DF55 Cluster: Phosphoribosylaminoimidazolecarboxamide... 61 2e-08
UniRef50_O67775 Cluster: Bifunctional purine biosynthesis protei... 61 2e-08
UniRef50_Q83EI4 Cluster: Phosphoribosylaminoimidazolecarboxamide... 61 3e-08
UniRef50_Q7X311 Cluster: Putative AICAR transformylase; n=1; unc... 61 3e-08
UniRef50_A7BET6 Cluster: Putative uncharacterized protein; n=1; ... 60 4e-08
UniRef50_A2SS05 Cluster: Phosphoribosylaminoimidazolecarboxamide... 60 4e-08
UniRef50_Q8D244 Cluster: Bifunctional purine biosynthesis protei... 60 4e-08
UniRef50_A7I7L2 Cluster: Phosphoribosylaminoimidazolecarboxamide... 60 5e-08
UniRef50_Q8XMK2 Cluster: Bifunctional purine biosynthesis protei... 60 5e-08
UniRef50_A0JTW4 Cluster: Phosphoribosylaminoimidazolecarboxamide... 60 7e-08
UniRef50_Q9PNY2 Cluster: Bifunctional purine biosynthesis protei... 60 7e-08
UniRef50_Q6L122 Cluster: Phosphoribosylaminoimidazolecarboxamide... 57 4e-07
UniRef50_A1IEQ8 Cluster: IMP cyclohydrolase; n=1; Candidatus Des... 56 1e-06
UniRef50_Q83GZ1 Cluster: Phosphoribosylaminoimidazolecarboxamide... 53 6e-06
UniRef50_Q89B23 Cluster: Bifunctional purine biosynthesis protei... 52 2e-05
UniRef50_Q316G8 Cluster: Phosphoribosylaminoimidazolecarboxamide... 51 3e-05
UniRef50_Q8A155 Cluster: Bifunctional purine biosynthesis protei... 49 1e-04
UniRef50_Q7VRP9 Cluster: Phosphoribosylaminoimidazolecarboxamide... 46 0.001
UniRef50_Q7MUT5 Cluster: Phosphoribosylaminoimidazolecarboxamide... 44 0.005
UniRef50_A1G3C3 Cluster: Phosphoribosylaminoimidazolecarboxamide... 42 0.011
UniRef50_Q8G6B1 Cluster: Bifunctional purine biosynthesis protei... 40 0.043
UniRef50_A7PK27 Cluster: Chromosome chr15 scaffold_19, whole gen... 39 0.099
UniRef50_UPI00006CA722 Cluster: hypothetical protein TTHERM_0084... 37 0.53
UniRef50_Q9X0X6 Cluster: Bifunctional purine biosynthesis protei... 37 0.53
UniRef50_A5B1A5 Cluster: DNA-directed RNA polymerase; n=1; Vitis... 33 4.9
UniRef50_Q54ZP8 Cluster: Putative homeobox transcription factor;... 33 6.5
UniRef50_A5KA45 Cluster: Putative uncharacterized protein; n=2; ... 33 6.5
UniRef50_UPI0000382898 Cluster: COG0138: AICAR transformylase/IM... 33 8.6
UniRef50_Q9F5Q0 Cluster: Putative uncharacterized protein; n=1; ... 33 8.6
>UniRef50_Q4SHT8 Cluster: Chromosome 5 SCAF14581, whole genome
shotgun sequence; n=3; Euteleostomi|Rep: Chromosome 5
SCAF14581, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 628
Score = 103 bits (247), Expect = 4e-21
Identities = 64/126 (50%), Positives = 74/126 (58%), Gaps = 3/126 (2%)
Frame = +1
Query: 313 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTAT---GASERRPHSSRCVGHHESTGDARR 483
ALLSVSDKTGL+ AK L + GL L+ASGGTA A S GH E G +
Sbjct: 1 ALLSVSDKTGLVQFAKRLVDVGLSLVASGGTAKTLRDAGWAVRDVSELTGHPEMLGGRVK 60
Query: 484 SGENFTSSVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADAVE 663
+ +VH GILAR S +D DM++ Y +I VVVCNLYPF P VTV DAVE
Sbjct: 61 T---LHPAVHGGILARKSPADTADMEKLGYSLIRVVVCNLYPF-VKTVSNPSVTVEDAVE 116
Query: 664 NIDIGG 681
IDIGG
Sbjct: 117 QIDIGG 122
Score = 52.0 bits (119), Expect = 1e-05
Identities = 23/33 (69%), Positives = 28/33 (84%)
Frame = +2
Query: 410 RALRNAGLTVQDVSDITRAPEMLGGRVKTLHPA 508
+ LR+AG V+DVS++T PEMLGGRVKTLHPA
Sbjct: 33 KTLRDAGWAVRDVSELTGHPEMLGGRVKTLHPA 65
>UniRef50_P31939 Cluster: Bifunctional purine biosynthesis protein
PURH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3)
(5-aminoimidazole-4-carboxamide ribonucleotide
formyltransferase) (AICAR transformylase); IMP
cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=105; cellular organisms|Rep:
Bifunctional purine biosynthesis protein PURH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3)
(5-aminoimidazole-4-carboxamide ribonucleotide
formyltransferase) (AICAR transformylase); IMP
cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Homo sapiens (Human)
Length = 592
Score = 97.1 bits (231), Expect = 4e-19
Identities = 61/129 (47%), Positives = 73/129 (56%), Gaps = 3/129 (2%)
Frame = +1
Query: 304 GKLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATG---ASERRPHSSRCVGHHESTGD 474
G+LAL SVSDKTGL+ A++L+ GL L+ASGGTA A S G E G
Sbjct: 4 GQLALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEMLGG 63
Query: 475 ARRSGENFTSSVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVAD 654
++ +VHAGILAR D DM R + +I VV CNLYPF P VTV +
Sbjct: 64 RVKT---LHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPF-VKTVASPGVTVEE 119
Query: 655 AVENIDIGG 681
AVE IDIGG
Sbjct: 120 AVEQIDIGG 128
Score = 56.8 bits (131), Expect = 5e-07
Identities = 26/37 (70%), Positives = 31/37 (83%)
Frame = +2
Query: 410 RALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAYMLG 520
+ALR+AGL V+DVS++T PEMLGGRVKTLHPA G
Sbjct: 39 KALRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAG 75
>UniRef50_P74741 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=49; root|Rep: Bifunctional purine
biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Synechocystis sp. (strain PCC
6803)
Length = 511
Score = 80.2 bits (189), Expect = 4e-14
Identities = 52/127 (40%), Positives = 71/127 (55%), Gaps = 2/127 (1%)
Frame = +1
Query: 307 KLALLSVSDKTGLLSLAKSL-SECGLQLIASGGTATGASERRPHSSRCVGHHESTGDARR 483
+LALLSVSDK+G++ LA+ L +E LI+SGGTA E ++ + +
Sbjct: 3 RLALLSVSDKSGIVELAQRLVNEFQFDLISSGGTAKTLKEAGVPVTKVSDYTGAPEILGG 62
Query: 484 SGENFTSSVHAGILARLS-DSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADAV 660
+ +H GILAR SDQ D++ + +VV NLYPF +P VTVA+AV
Sbjct: 63 RVKTLHPRIHGGILARRDLPSDQADLEANDIRPLDLVVVNLYPFEQT-IAKPGVTVAEAV 121
Query: 661 ENIDIGG 681
E IDIGG
Sbjct: 122 EQIDIGG 128
Score = 47.2 bits (107), Expect = 4e-04
Identities = 21/32 (65%), Positives = 25/32 (78%)
Frame = +2
Query: 410 RALRNAGLTVQDVSDITRAPEMLGGRVKTLHP 505
+ L+ AG+ V VSD T APE+LGGRVKTLHP
Sbjct: 38 KTLKEAGVPVTKVSDYTGAPEILGGRVKTLHP 69
>UniRef50_Q73LG8 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=2; Bacteria|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Treponema
denticola
Length = 533
Score = 78.6 bits (185), Expect = 1e-13
Identities = 48/124 (38%), Positives = 60/124 (48%)
Frame = +1
Query: 310 LALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASERRPHSSRCVGHHESTGDARRSG 489
L L SVSDKTGL A L G IASGGTA E + S
Sbjct: 3 LVLASVSDKTGLKDFAFRLKAAGYDFIASGGTAKTLQEAGIKVKEVSEYTSSPEILGGRV 62
Query: 490 ENFTSSVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADAVENI 669
+ +H GILAR + D+ ++K + I +V+ NLYPF PD T +D +ENI
Sbjct: 63 KTLHPMIHGGILARDTKEDRAELKALGFSGIDIVIANLYPFEKT-ISSPDSTESDCIENI 121
Query: 670 DIGG 681
DIGG
Sbjct: 122 DIGG 125
Score = 46.8 bits (106), Expect = 5e-04
Identities = 19/32 (59%), Positives = 27/32 (84%)
Frame = +2
Query: 410 RALRNAGLTVQDVSDITRAPEMLGGRVKTLHP 505
+ L+ AG+ V++VS+ T +PE+LGGRVKTLHP
Sbjct: 36 KTLQEAGIKVKEVSEYTSSPEILGGRVKTLHP 67
>UniRef50_P43852 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=88; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Haemophilus influenzae
Length = 532
Score = 78.2 bits (184), Expect = 2e-13
Identities = 56/126 (44%), Positives = 72/126 (57%), Gaps = 3/126 (2%)
Frame = +1
Query: 313 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTA-TGASERRP--HSSRCVGHHESTGDARR 483
ALLSVSDKTG++ A+ L + G++L+++GGTA A P S G E D R
Sbjct: 9 ALLSVSDKTGIVEFAQGLVKRGVKLLSTGGTAKLLAQNALPVIEVSDYTGFPEMM-DGR- 66
Query: 484 SGENFTSSVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADAVE 663
+ VH GIL R +D M++ E I +VV NLYPF +PD T+ADAVE
Sbjct: 67 -VKTLHPKVHGGILGR-RGTDDAIMQQHGIEGIDMVVVNLYPFAAT-VAKPDCTLADAVE 123
Query: 664 NIDIGG 681
NIDIGG
Sbjct: 124 NIDIGG 129
>UniRef50_Q2JI00 Cluster: Bifunctional purine biosynthesis protein
PurH; n=1; Synechococcus sp. JA-2-3B'a(2-13)|Rep:
Bifunctional purine biosynthesis protein PurH -
Synechococcus sp. (strain JA-2-3B'a(2-13))
(Cyanobacteria bacteriumYellowstone B-Prime)
Length = 577
Score = 77.8 bits (183), Expect = 2e-13
Identities = 53/126 (42%), Positives = 69/126 (54%), Gaps = 2/126 (1%)
Frame = +1
Query: 310 LALLSVSDKTGLLSLAKSL-SECGLQLIASGGTATGASERRPHSSRCVGHHESTGDARRS 486
LALLSVSDKTGL+ LA+SL E G QL++SGGTA SE + H +
Sbjct: 17 LALLSVSDKTGLIPLAQSLVQEHGFQLLSSGGTAKALSEAGIPVTPVSAHTGAPEILGGR 76
Query: 487 GENFTSSVHAGILARLSDS-DQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADAVE 663
+ +H GILARL S D+ D++ I +VV N YPF + V++ +A E
Sbjct: 77 VKTLHPRIHGGILARLECSEDRADLEALGIPPIQLVVVNFYPFE-QTVAQAGVSLEEAFE 135
Query: 664 NIDIGG 681
IDIGG
Sbjct: 136 QIDIGG 141
Score = 44.0 bits (99), Expect = 0.003
Identities = 21/32 (65%), Positives = 24/32 (75%)
Frame = +2
Query: 410 RALRNAGLTVQDVSDITRAPEMLGGRVKTLHP 505
+AL AG+ V VS T APE+LGGRVKTLHP
Sbjct: 51 KALSEAGIPVTPVSAHTGAPEILGGRVKTLHP 82
>UniRef50_P67543 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=18; Staphylococcus|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Staphylococcus aureus (strain Mu50
/ ATCC 700699)
Length = 492
Score = 77.4 bits (182), Expect = 3e-13
Identities = 49/128 (38%), Positives = 71/128 (55%), Gaps = 3/128 (2%)
Frame = +1
Query: 307 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASERR--PHSSRCVGHHESTGDAR 480
K A+LSVS+KTG++ AK+L++ +L ++GGT E S + H D R
Sbjct: 2 KKAILSVSNKTGIVEFAKALTQLNYELYSTGGTKRILDEANVPVRSVSDLTHFPEIMDGR 61
Query: 481 RSGENFTSSVHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADA 657
+ +VH GILA R ++ Q ++I +VV NLYPF+ PDVT+ +A
Sbjct: 62 --VKTLHPAVHGGILADRNKPQHLNELSEQHIDLIDMVVVNLYPFQ-QTVANPDVTMDEA 118
Query: 658 VENIDIGG 681
+ENIDIGG
Sbjct: 119 IENIDIGG 126
Score = 42.7 bits (96), Expect = 0.008
Identities = 19/33 (57%), Positives = 24/33 (72%)
Frame = +2
Query: 410 RALRNAGLTVQDVSDITRAPEMLGGRVKTLHPA 508
R L A + V+ VSD+T PE++ GRVKTLHPA
Sbjct: 36 RILDEANVPVRSVSDLTHFPEIMDGRVKTLHPA 68
>UniRef50_Q8ZAR3 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=59; Proteobacteria|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Yersinia pestis
Length = 529
Score = 76.6 bits (180), Expect = 5e-13
Identities = 53/126 (42%), Positives = 69/126 (54%), Gaps = 3/126 (2%)
Frame = +1
Query: 313 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTA---TGASERRPHSSRCVGHHESTGDARR 483
ALLSVSDK G++ A++LS+ G++L+++GGTA A S G E D R
Sbjct: 10 ALLSVSDKAGIIEFAQALSQRGIELLSTGGTARLLADAGLPVTEVSDYTGFPEMM-DGR- 67
Query: 484 SGENFTSSVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADAVE 663
+ VH GIL R D M + + I +VV NLYPF RPD ++ DAVE
Sbjct: 68 -VKTLHPKVHGGILGR-RGQDDGIMAQHGIQPIDIVVVNLYPF-AQTVARPDCSLEDAVE 124
Query: 664 NIDIGG 681
NIDIGG
Sbjct: 125 NIDIGG 130
Score = 45.2 bits (102), Expect = 0.002
Identities = 21/32 (65%), Positives = 24/32 (75%)
Frame = +2
Query: 410 RALRNAGLTVQDVSDITRAPEMLGGRVKTLHP 505
R L +AGL V +VSD T PEM+ GRVKTLHP
Sbjct: 42 RLLADAGLPVTEVSDYTGFPEMMDGRVKTLHP 73
>UniRef50_Q2JR47 Cluster: Bifunctional purine biosynthesis protein
PurH; n=12; Bacteria|Rep: Bifunctional purine
biosynthesis protein PurH - Synechococcus sp. (strain
JA-3-3Ab) (Cyanobacteria bacteriumYellowstone A-Prime)
Length = 537
Score = 76.2 bits (179), Expect = 7e-13
Identities = 52/126 (41%), Positives = 68/126 (53%), Gaps = 2/126 (1%)
Frame = +1
Query: 310 LALLSVSDKTGLLSLAKSL-SECGLQLIASGGTATGASERRPHSSRCVGHHESTGDARRS 486
LALLSVSDKTGL+ LA++L E G QL++SGGTA SE + H +
Sbjct: 9 LALLSVSDKTGLIPLAQALVQEHGFQLLSSGGTAKALSEAGIPVTPVSEHTGAPEILGGR 68
Query: 487 GENFTSSVHAGILARLS-DSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADAVE 663
+ +H GILARL D+ D++ I +VV N YPF R V++ +A E
Sbjct: 69 VKTLHPRIHGGILARLERREDRADLEALGIPPIQLVVVNFYPFE-QTVARAGVSLEEAFE 127
Query: 664 NIDIGG 681
IDIGG
Sbjct: 128 QIDIGG 133
Score = 45.6 bits (103), Expect = 0.001
Identities = 21/32 (65%), Positives = 25/32 (78%)
Frame = +2
Query: 410 RALRNAGLTVQDVSDITRAPEMLGGRVKTLHP 505
+AL AG+ V VS+ T APE+LGGRVKTLHP
Sbjct: 43 KALSEAGIPVTPVSEHTGAPEILGGRVKTLHP 74
>UniRef50_P12048 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=71; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Bacillus subtilis
Length = 512
Score = 74.9 bits (176), Expect = 2e-12
Identities = 50/133 (37%), Positives = 74/133 (55%), Gaps = 6/133 (4%)
Frame = +1
Query: 307 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASERRPHSSRCVGHHESTG----- 471
K AL+SVSDKT L+ K L+E G+++I++GGT E + +G E TG
Sbjct: 4 KRALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQE---NGVDVIGISEVTGFPEIM 60
Query: 472 DARRSGENFTSSVHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTV 648
D R + ++H G+LA R ++ + + I +VV NLYPF+ + + DVT
Sbjct: 61 DGRL--KTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVNLYPFK-ETISKEDVTY 117
Query: 649 ADAVENIDIGGRG 687
+A+ENIDIGG G
Sbjct: 118 EEAIENIDIGGPG 130
>UniRef50_A1K9K5 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=2; Bacteria|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Azoarcus sp.
(strain BH72)
Length = 527
Score = 74.5 bits (175), Expect = 2e-12
Identities = 47/124 (37%), Positives = 66/124 (53%), Gaps = 1/124 (0%)
Frame = +1
Query: 313 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASERRPHSSRCVGHHESTGDARRSGE 492
AL+SVSDK G+L A+ L+ G++L+++GGTA + + H +
Sbjct: 6 ALISVSDKRGVLDFARELAGLGIKLLSTGGTAALLRDAGLPVTDVSEHTGFPEMLDGRVK 65
Query: 493 NFTSSVHAGILARLSDSDQED-MKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADAVENI 669
VH GILAR ++ D + I +VV NLYPF+ RPD T+ DA+ENI
Sbjct: 66 TLHPKVHGGILARRDLAEHMDTIAAHDISRIDLVVVNLYPFQAT-VARPDCTLEDAIENI 124
Query: 670 DIGG 681
DIGG
Sbjct: 125 DIGG 128
Score = 46.0 bits (104), Expect = 9e-04
Identities = 22/30 (73%), Positives = 24/30 (80%)
Frame = +2
Query: 416 LRNAGLTVQDVSDITRAPEMLGGRVKTLHP 505
LR+AGL V DVS+ T PEML GRVKTLHP
Sbjct: 40 LRDAGLPVTDVSEHTGFPEMLDGRVKTLHP 69
>UniRef50_Q9F1T4 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=57; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Streptococcus suis
Length = 515
Score = 74.5 bits (175), Expect = 2e-12
Identities = 48/129 (37%), Positives = 70/129 (54%), Gaps = 4/129 (3%)
Frame = +1
Query: 307 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASERRPHSSRCVGHHESTGDARRS 486
K AL+SVSDK G++ A+ L++ G ++I++GGT + + + TG
Sbjct: 3 KRALISVSDKNGIVEFAQELTKFGWEIISTGGTKVALDQA---GVTTIAIDDVTGFPEMM 59
Query: 487 G---ENFTSSVHAGILARLS-DSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVAD 654
+ +H G+LAR DS + + +I +VV NLYPF+ + LRPDVT
Sbjct: 60 DGRVKTLHPKIHGGLLARRDLDSHLQAANDHEIGLIDLVVVNLYPFK-ETILRPDVTYDL 118
Query: 655 AVENIDIGG 681
AVENIDIGG
Sbjct: 119 AVENIDIGG 127
Score = 41.1 bits (92), Expect = 0.025
Identities = 18/31 (58%), Positives = 22/31 (70%)
Frame = +2
Query: 413 ALRNAGLTVQDVSDITRAPEMLGGRVKTLHP 505
AL AG+T + D+T PEM+ GRVKTLHP
Sbjct: 38 ALDQAGVTTIAIDDVTGFPEMMDGRVKTLHP 68
>UniRef50_A5E8X1 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase /IMP cyclohydrolase; n=4;
Bacteria|Rep: Phosphoribosylaminoimidazolecarboxamide
formyltransferase /IMP cyclohydrolase - Bradyrhizobium
sp. (strain BTAi1 / ATCC BAA-1182)
Length = 530
Score = 73.3 bits (172), Expect = 5e-12
Identities = 51/127 (40%), Positives = 70/127 (55%), Gaps = 4/127 (3%)
Frame = +1
Query: 313 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASE---RRPHSSRCVGHHESTGDARR 483
ALLSVSDKTGL+ A+SL+ G++LI++GGTA ++ + S G E D R
Sbjct: 11 ALLSVSDKTGLVEFARSLAARGIELISTGGTAKAIADAGLKVKDVSDLTGFPEMM-DGR- 68
Query: 484 SGENFTSSVHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADAV 660
+ VH G+LA R +D E MK I ++V NLYPF + + +D +
Sbjct: 69 -VKTLHPKVHGGLLAIRGNDEHAEAMKTHGIAPIDLLVVNLYPF--EATVERSAPFSDCI 125
Query: 661 ENIDIGG 681
ENIDIGG
Sbjct: 126 ENIDIGG 132
Score = 48.8 bits (111), Expect = 1e-04
Identities = 21/32 (65%), Positives = 27/32 (84%)
Frame = +2
Query: 410 RALRNAGLTVQDVSDITRAPEMLGGRVKTLHP 505
+A+ +AGL V+DVSD+T PEM+ GRVKTLHP
Sbjct: 43 KAIADAGLKVKDVSDLTGFPEMMDGRVKTLHP 74
>UniRef50_Q8PYG4 Cluster: Formyltransferase
phosphoribosylaminoimidazolecarboxamide; n=4;
Methanosarcinaceae|Rep: Formyltransferase
phosphoribosylaminoimidazolecarboxamide - Methanosarcina
mazei (Methanosarcina frisia)
Length = 538
Score = 72.5 bits (170), Expect = 9e-12
Identities = 46/129 (35%), Positives = 69/129 (53%), Gaps = 4/129 (3%)
Frame = +1
Query: 307 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTA---TGASERRPHSSRCVGHHESTGDA 477
K ALLSVSDKTG++ A+ L G+++I++GGTA A S G+ E G
Sbjct: 3 KRALLSVSDKTGIVEFARGLEALGVKIISTGGTAKILRDADIEVTDVSEVTGYPEMMGGR 62
Query: 478 RRSGENFTSSVHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVAD 654
++ +H G+L R S E+ ++ +I ++ NLYPF R +V + +
Sbjct: 63 VKT---LHPRIHGGLLCLRESKEQMEEAAKEDISLIDLIAVNLYPFEIT-VSRENVELEE 118
Query: 655 AVENIDIGG 681
A+ENIDIGG
Sbjct: 119 AIENIDIGG 127
Score = 47.2 bits (107), Expect = 4e-04
Identities = 20/32 (62%), Positives = 26/32 (81%)
Frame = +2
Query: 410 RALRNAGLTVQDVSDITRAPEMLGGRVKTLHP 505
+ LR+A + V DVS++T PEM+GGRVKTLHP
Sbjct: 37 KILRDADIEVTDVSEVTGYPEMMGGRVKTLHP 68
>UniRef50_Q8CXK7 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=34; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Oceanobacillus iheyensis
Length = 510
Score = 70.9 bits (166), Expect = 3e-11
Identities = 45/129 (34%), Positives = 67/129 (51%), Gaps = 4/129 (3%)
Frame = +1
Query: 307 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASERR---PHSSRCVGHHESTGDA 477
K AL+SVSDKT ++ AK L E G +++++GGT +E G E D
Sbjct: 3 KRALISVSDKTNIIEFAKGLKESGFEILSTGGTLRSIAEAGIDVTPVDEVTGFPEML-DG 61
Query: 478 RRSGENFTSSVHAGILARLSDSDQ-EDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVAD 654
R + +H G+L + S+ + M+ I +V NLYPF+ + +PDV+ D
Sbjct: 62 R--VKTLHPMIHGGLLGKRSNHEHLSQMEEHGIRSIDLVAVNLYPFK-ETVQKPDVSHQD 118
Query: 655 AVENIDIGG 681
+ENIDIGG
Sbjct: 119 IIENIDIGG 127
>UniRef50_Q8F3W6 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=6; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Leptospira interrogans
Length = 511
Score = 70.1 bits (164), Expect = 5e-11
Identities = 47/131 (35%), Positives = 75/131 (57%), Gaps = 6/131 (4%)
Frame = +1
Query: 307 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASERRPHSSRCVGHHESTG----- 471
K AL+SVSDK+GL+ AK L++ G+++I++GGT + + + + TG
Sbjct: 5 KRALISVSDKSGLVEFAKFLNQNGVEIISTGGT---LKLLKDNGIAAIAIDDYTGFPEIL 61
Query: 472 DARRSGENFTSSVHAGILARLSD-SDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTV 648
D R + VH G+L +S+ + ++ M+ K I +VV NLYPF +P+V +
Sbjct: 62 DGR--VKTLHPKVHGGLLGVISNPAHKQKMEELKIPKIDLVVVNLYPFLKT-VSKPEVQL 118
Query: 649 ADAVENIDIGG 681
+A+ENIDIGG
Sbjct: 119 EEAIENIDIGG 129
>UniRef50_UPI00015BCE7E Cluster: UPI00015BCE7E related cluster; n=1;
unknown|Rep: UPI00015BCE7E UniRef100 entry - unknown
Length = 506
Score = 68.5 bits (160), Expect = 1e-10
Identities = 49/127 (38%), Positives = 64/127 (50%), Gaps = 4/127 (3%)
Frame = +1
Query: 313 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTAT---GASERRPHSSRCVGHHESTGDARR 483
AL+SV DKTG+L LAK L G ++++SGGT T A S G E G +
Sbjct: 3 ALISVYDKTGILELAKELLNQGYEILSSGGTYTYLKNAGVDAIEVSEVTGFREILGGRVK 62
Query: 484 SGENFTSSVHAGILARLS-DSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADAV 660
+ ++H GIL R + D E++K E I +VV NLYPF D+ V
Sbjct: 63 T---LHPAIHGGILFREDVEKDLEEIKENSIEPIDIVVVNLYPFEKKMKELKDIDA--LV 117
Query: 661 ENIDIGG 681
E IDIGG
Sbjct: 118 EFIDIGG 124
Score = 43.2 bits (97), Expect = 0.006
Identities = 19/31 (61%), Positives = 25/31 (80%)
Frame = +2
Query: 416 LRNAGLTVQDVSDITRAPEMLGGRVKTLHPA 508
L+NAG+ +VS++T E+LGGRVKTLHPA
Sbjct: 37 LKNAGVDAIEVSEVTGFREILGGRVKTLHPA 67
>UniRef50_Q6MIZ2 Cluster: IMP cyclohydrolase; n=1; Bdellovibrio
bacteriovorus|Rep: IMP cyclohydrolase - Bdellovibrio
bacteriovorus
Length = 507
Score = 68.5 bits (160), Expect = 1e-10
Identities = 49/125 (39%), Positives = 66/125 (52%), Gaps = 2/125 (1%)
Frame = +1
Query: 313 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASERRPHSSRCVGHHESTGDARRSG- 489
ALLSVSDKTGLL LAK+L+ ++LIASGGTA +E + V G+A
Sbjct: 7 ALLSVSDKTGLLELAKNLAAQNVELIASGGTAKALTEAGLKVT-AVETLSGKGEAFNGRM 65
Query: 490 ENFTSSVHAGILARLSD-SDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADAVEN 666
+ + + + +L R D +D E I +VV NLYPF L+ + +EN
Sbjct: 66 KTISFEIASSLLFRRQDENDVRQAAELGIEPIDLVVVNLYPFH--ATLQKQAGFEECIEN 123
Query: 667 IDIGG 681
IDIGG
Sbjct: 124 IDIGG 128
>UniRef50_Q1V178 Cluster: Bifunctional purine biosynthesis protein;
n=2; Candidatus Pelagibacter ubique|Rep: Bifunctional
purine biosynthesis protein - Candidatus Pelagibacter
ubique HTCC1002
Length = 518
Score = 68.5 bits (160), Expect = 1e-10
Identities = 46/129 (35%), Positives = 71/129 (55%), Gaps = 4/129 (3%)
Frame = +1
Query: 307 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASERRPHSSRCVGHHESTGDARRS 486
K AL+SVSDK L SL + L++ ++LI+SGGT E + +C E TG
Sbjct: 12 KKALISVSDKKDLGSLLRVLAKYKIELISSGGT---FKEIKKLKFKCQEVSEYTGSPEIL 68
Query: 487 G---ENFTSSVHAGILARLSD-SDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVAD 654
G + +HAGIL++ +D S +++K +Y+ I +V+ N YPF + L +
Sbjct: 69 GGRVKTLHPKIHAGILSKRNDKSHTKELKANQYDEIDLVIVNFYPF--EKTLDQTTNHSK 126
Query: 655 AVENIDIGG 681
+ENID+GG
Sbjct: 127 IIENIDVGG 135
Score = 39.5 bits (88), Expect = 0.075
Identities = 17/27 (62%), Positives = 21/27 (77%)
Frame = +2
Query: 440 QDVSDITRAPEMLGGRVKTLHPAYMLG 520
Q+VS+ T +PE+LGGRVKTLHP G
Sbjct: 56 QEVSEYTGSPEILGGRVKTLHPKIHAG 82
>UniRef50_Q550I9 Cluster: AICAR transformylase / IMP cyclohydrolase;
n=2; Dictyostelium discoideum|Rep: AICAR transformylase
/ IMP cyclohydrolase - Dictyostelium discoideum AX4
Length = 542
Score = 68.1 bits (159), Expect = 2e-10
Identities = 45/126 (35%), Positives = 67/126 (53%), Gaps = 3/126 (2%)
Frame = +1
Query: 313 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASER--RPHSSRCVGHHESTGDARRS 486
ALLSV +K+G++ +K LS G LI++GGTA + + V + D R
Sbjct: 3 ALLSVYNKSGIVEFSKILSSKGFNLISTGGTAKSLVDNGLKVQQVSDVTEYPEMLDGR-- 60
Query: 487 GENFTSSVHAGILARLS-DSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADAVE 663
+ +H G+LAR Q D+ + + IS+VV NLYPF + + T+ +A+E
Sbjct: 61 VKTLHPKIHGGLLARPELAHHQADLNKYNIKPISIVVVNLYPF-VETVSKESTTLEEAIE 119
Query: 664 NIDIGG 681
NIDIGG
Sbjct: 120 NIDIGG 125
Score = 46.4 bits (105), Expect = 7e-04
Identities = 21/32 (65%), Positives = 25/32 (78%)
Frame = +2
Query: 410 RALRNAGLTVQDVSDITRAPEMLGGRVKTLHP 505
++L + GL VQ VSD+T PEML GRVKTLHP
Sbjct: 35 KSLVDNGLKVQQVSDVTEYPEMLDGRVKTLHP 66
>UniRef50_Q9PC10 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=214; cellular organisms|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Xylella fastidiosa
Length = 527
Score = 67.3 bits (157), Expect = 3e-10
Identities = 49/126 (38%), Positives = 68/126 (53%), Gaps = 3/126 (2%)
Frame = +1
Query: 313 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASERR---PHSSRCVGHHESTGDARR 483
ALLSVSDKTGL+ LA++L ++L+++GGTAT E + G E D R
Sbjct: 11 ALLSVSDKTGLVELARALLAYNIELLSTGGTATIIREAGLPVQDVADLTGFPEMM-DGR- 68
Query: 484 SGENFTSSVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADAVE 663
+ VH G+L R + D M + I +++ NLYPF + D T+ADAV+
Sbjct: 69 -VKTLHPMVHGGLLGR-AGIDDAVMAKHGIAPIDLLILNLYPFE-QITAKKDCTLADAVD 125
Query: 664 NIDIGG 681
IDIGG
Sbjct: 126 TIDIGG 131
Score = 48.8 bits (111), Expect = 1e-04
Identities = 21/30 (70%), Positives = 25/30 (83%)
Frame = +2
Query: 416 LRNAGLTVQDVSDITRAPEMLGGRVKTLHP 505
+R AGL VQDV+D+T PEM+ GRVKTLHP
Sbjct: 45 IREAGLPVQDVADLTGFPEMMDGRVKTLHP 74
>UniRef50_A7HM64 Cluster: IMP cyclohydrolase; n=1; Fervidobacterium
nodosum Rt17-B1|Rep: IMP cyclohydrolase -
Fervidobacterium nodosum Rt17-B1
Length = 429
Score = 66.5 bits (155), Expect = 6e-10
Identities = 51/131 (38%), Positives = 69/131 (52%), Gaps = 4/131 (3%)
Frame = +1
Query: 301 NGKLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASERR---PHSSRCVGHHESTG 471
N K AL+SVSDK GL+ AK+L + G+++I++GGTA S+ S G E G
Sbjct: 2 NIKRALISVSDKAGLVEFAKNLVDRGVEIISTGGTAKLLSDAGIPVKQVSDVTGFPEILG 61
Query: 472 DARRSGENFTSSVHAGILARLSD-SDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTV 648
++ + GILA L D S +D++ E I +VV NLYPF D V
Sbjct: 62 GRVKT---LHPKIFGGILADLGDKSHVKDLRDNFIEPIDLVVVNLYPFDEVQKKTRDEDV 118
Query: 649 ADAVENIDIGG 681
+ENIDIGG
Sbjct: 119 --LIENIDIGG 127
Score = 46.8 bits (106), Expect = 5e-04
Identities = 20/32 (62%), Positives = 26/32 (81%)
Frame = +2
Query: 410 RALRNAGLTVQDVSDITRAPEMLGGRVKTLHP 505
+ L +AG+ V+ VSD+T PE+LGGRVKTLHP
Sbjct: 38 KLLSDAGIPVKQVSDVTGFPEILGGRVKTLHP 69
>UniRef50_Q9FPL3 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=14;
Viridiplantae|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Nicotiana tabacum
(Common tobacco)
Length = 612
Score = 66.5 bits (155), Expect = 6e-10
Identities = 47/136 (34%), Positives = 66/136 (48%), Gaps = 4/136 (2%)
Frame = +1
Query: 286 QNMASNGKLALLSVSDKTGLLSLAKSLSECGLQLIASGGTAT---GASERRPHSSRCVGH 456
++ S K AL+S+SDKT L L L E G ++++GGT++ GA
Sbjct: 82 KSSTSGRKQALISLSDKTDLAKLGNGLQELGYTIVSTGGTSSALEGAGVSVTKVEELTRF 141
Query: 457 HESTGDARRSGENFTSSVHAGILARL-SDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLR 633
E D R + SVH GILAR + E +++ + VVV NLYPF
Sbjct: 142 PEML-DGR--VKTLHPSVHGGILARRDQEHHMEALEKHEIGTFDVVVVNLYPFYAKVSSS 198
Query: 634 PDVTVADAVENIDIGG 681
++ D +ENIDIGG
Sbjct: 199 SGISFEDGIENIDIGG 214
Score = 45.6 bits (103), Expect = 0.001
Identities = 20/32 (62%), Positives = 25/32 (78%)
Frame = +2
Query: 413 ALRNAGLTVQDVSDITRAPEMLGGRVKTLHPA 508
AL AG++V V ++TR PEML GRVKTLHP+
Sbjct: 124 ALEGAGVSVTKVEELTRFPEMLDGRVKTLHPS 155
>UniRef50_A6G003 Cluster: Bifunctional
phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=1; Plesiocystis
pacifica SIR-1|Rep: Bifunctional
phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Plesiocystis
pacifica SIR-1
Length = 543
Score = 65.3 bits (152), Expect = 1e-09
Identities = 47/126 (37%), Positives = 69/126 (54%), Gaps = 3/126 (2%)
Frame = +1
Query: 313 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASERRPHSSRCVGHHESTGDAR-RSG 489
AL+SVSDK+ L LA+ L ++++++GGT SE V E TG G
Sbjct: 17 ALVSVSDKSKLDVLAEILIAHKVEVLSTGGTYRALSEL---GVAVVKVSEFTGAPEILDG 73
Query: 490 ENFT--SSVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADAVE 663
T +H GILA +++ Q +++ I +V+ NLYPFR + +P + ADA+E
Sbjct: 74 RVKTLHPKIHGGILALPTEAHQRELELHDIAPIDLVIVNLYPFR-ETIAKPGCSFADAIE 132
Query: 664 NIDIGG 681
NIDIGG
Sbjct: 133 NIDIGG 138
Score = 43.2 bits (97), Expect = 0.006
Identities = 24/44 (54%), Positives = 28/44 (63%)
Frame = +2
Query: 410 RALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAYMLGS*LDYPT 541
RAL G+ V VS+ T APE+L GRVKTLHP + G L PT
Sbjct: 49 RALSELGVAVVKVSEFTGAPEILDGRVKTLHPK-IHGGILALPT 91
>UniRef50_Q9RW01 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=3; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Deinococcus radiodurans
Length = 510
Score = 62.5 bits (145), Expect = 9e-09
Identities = 46/128 (35%), Positives = 63/128 (49%), Gaps = 3/128 (2%)
Frame = +1
Query: 307 KLALLSVSDKTGLLSLAKSLSECGLQLIASGG---TATGASERRPHSSRCVGHHESTGDA 477
K AL+SVSDKTG++ A L + G +L+++GG T +GA S G E D
Sbjct: 3 KRALISVSDKTGVVEFAAQLQQRGWELLSTGGTFATLSGAGIPVRQVSDVTGFPEML-DG 61
Query: 478 RRSGENFTSSVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADA 657
R + ++H GILAR + Q I +V NLYPFR + +
Sbjct: 62 R--VKTLHPAIHGGILARREAGHLGQLAAQDIGTIDLVCVNLYPFRET--VARGAPDPEV 117
Query: 658 VENIDIGG 681
+ENIDIGG
Sbjct: 118 IENIDIGG 125
Score = 46.4 bits (105), Expect = 7e-04
Identities = 21/31 (67%), Positives = 24/31 (77%)
Frame = +2
Query: 416 LRNAGLTVQDVSDITRAPEMLGGRVKTLHPA 508
L AG+ V+ VSD+T PEML GRVKTLHPA
Sbjct: 39 LSGAGIPVRQVSDVTGFPEMLDGRVKTLHPA 69
>UniRef50_A7DF55 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=3;
Alphaproteobacteria|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Methylobacterium
extorquens PA1
Length = 581
Score = 61.3 bits (142), Expect = 2e-08
Identities = 45/126 (35%), Positives = 63/126 (50%), Gaps = 3/126 (2%)
Frame = +1
Query: 313 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASER--RPHSSRCVGHHESTGDARRS 486
ALLSVSDKTGL A +LS+ G++L+++GGT +E + D R
Sbjct: 60 ALLSVSDKTGLTDFAAALSQRGVELVSTGGTHRALTEAGLAVREVSELTRFPEMMDGRV- 118
Query: 487 GENFTSSVHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADAVE 663
+ +VH G+LA R + Q + I ++V NLYPF L+ D VE
Sbjct: 119 -KTLHPAVHGGLLAVRDNPEHQAALAAHGIGAIDLLVVNLYPFEET--LKAGKAYDDCVE 175
Query: 664 NIDIGG 681
NID+GG
Sbjct: 176 NIDVGG 181
Score = 52.0 bits (119), Expect = 1e-05
Identities = 23/33 (69%), Positives = 28/33 (84%)
Frame = +2
Query: 410 RALRNAGLTVQDVSDITRAPEMLGGRVKTLHPA 508
RAL AGL V++VS++TR PEM+ GRVKTLHPA
Sbjct: 92 RALTEAGLAVREVSELTRFPEMMDGRVKTLHPA 124
>UniRef50_O67775 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=9; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Aquifex aeolicus
Length = 506
Score = 61.3 bits (142), Expect = 2e-08
Identities = 46/127 (36%), Positives = 69/127 (54%), Gaps = 4/127 (3%)
Frame = +1
Query: 313 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASERR---PHSSRCVGHHESTGDARR 483
A++SV K G+ LAK+L E G +++++GGTA E+ S G E + R
Sbjct: 3 AIISVYRKEGIDKLAKALQELGYEIVSTGGTAKYLREKGISVKEVSEITGFPEIL-EGR- 60
Query: 484 SGENFTSSVHAGILAR-LSDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADAV 660
+ VH GIL R + D+E++++ + I VVV NLYPF + L+ +T D +
Sbjct: 61 -VKTLHPVVHGGILFRDWVEKDKEEIEKHGIKPIDVVVVNLYPF--EEKLKEGLTDKDLM 117
Query: 661 ENIDIGG 681
E IDIGG
Sbjct: 118 EFIDIGG 124
Score = 43.6 bits (98), Expect = 0.005
Identities = 19/30 (63%), Positives = 25/30 (83%)
Frame = +2
Query: 416 LRNAGLTVQDVSDITRAPEMLGGRVKTLHP 505
LR G++V++VS+IT PE+L GRVKTLHP
Sbjct: 37 LREKGISVKEVSEITGFPEILEGRVKTLHP 66
>UniRef50_Q83EI4 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=5; Coxiella
burnetii|Rep: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Coxiella burnetii
Length = 526
Score = 60.9 bits (141), Expect = 3e-08
Identities = 43/128 (33%), Positives = 65/128 (50%), Gaps = 3/128 (2%)
Frame = +1
Query: 307 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASERRPHSSRCVGHHESTGDAR-R 483
K AL+S +DK GL+ L CG+++IA+GGT A + H + TG
Sbjct: 12 KRALISTADKIGLIEFISQLVTCGVEIIATGGT---AELLKQHQLPVIDVFTYTGFPEIM 68
Query: 484 SG--ENFTSSVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADA 657
G + +HAG+LAR D++ + + + I ++V NLYPF + ++ A
Sbjct: 69 DGRVKTLHPKIHAGLLAR-RGIDEKTLDQHAIKPIDLLVVNLYPF-VQTVSASNCSLEKA 126
Query: 658 VENIDIGG 681
VE IDIGG
Sbjct: 127 VEQIDIGG 134
>UniRef50_Q7X311 Cluster: Putative AICAR transformylase; n=1;
uncultured Acidobacteria bacterium|Rep: Putative AICAR
transformylase - uncultured Acidobacteria bacterium
Length = 571
Score = 60.9 bits (141), Expect = 3e-08
Identities = 45/127 (35%), Positives = 65/127 (51%), Gaps = 4/127 (3%)
Frame = +1
Query: 313 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASE---RRPHSSRCVGHHESTGDARR 483
AL+SVSDKTG++ A L ++++++GGTA E S G E D R
Sbjct: 15 ALISVSDKTGIVDFASELRAFDIEIVSTGGTAKTLREAGIEVRDVSDVTGFPEMM-DGR- 72
Query: 484 SGENFTSSVHAGIL-ARLSDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADAV 660
+ +H G+L R S S + M+ E I +VV +LYPF V++A+A+
Sbjct: 73 -VKTLHPKIHGGLLGVRDSPSHESSMREHGIEPIDMVVIDLYPFERT-IKGAAVSLAEAI 130
Query: 661 ENIDIGG 681
E IDIGG
Sbjct: 131 EQIDIGG 137
Score = 49.6 bits (113), Expect = 7e-05
Identities = 21/32 (65%), Positives = 26/32 (81%)
Frame = +2
Query: 410 RALRNAGLTVQDVSDITRAPEMLGGRVKTLHP 505
+ LR AG+ V+DVSD+T PEM+ GRVKTLHP
Sbjct: 47 KTLREAGIEVRDVSDVTGFPEMMDGRVKTLHP 78
>UniRef50_A7BET6 Cluster: Putative uncharacterized protein; n=1;
Actinomyces odontolyticus ATCC 17982|Rep: Putative
uncharacterized protein - Actinomyces odontolyticus ATCC
17982
Length = 614
Score = 60.5 bits (140), Expect = 4e-08
Identities = 43/129 (33%), Positives = 67/129 (51%), Gaps = 4/129 (3%)
Frame = +1
Query: 307 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTAT---GASERRPHSSRCVGHHESTGDA 477
K AL+SV DKTGL LA++L E G++++++G TA A G E
Sbjct: 17 KRALISVYDKTGLEDLARALGEAGVEIVSTGSTAARIAAAGVAVTPVDDVTGFPEVLEGR 76
Query: 478 RRSGENFTSSVHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVAD 654
++ F +H+GILA + + +E + + + +VVCNLYPF+ + + +
Sbjct: 77 VKTLHPF---IHSGILADQRKAAHREQIAQLGIQAFDLVVCNLYPFQDT--VASGASFDE 131
Query: 655 AVENIDIGG 681
VE IDIGG
Sbjct: 132 CVEQIDIGG 140
Score = 38.7 bits (86), Expect = 0.13
Identities = 17/27 (62%), Positives = 20/27 (74%)
Frame = +2
Query: 425 AGLTVQDVSDITRAPEMLGGRVKTLHP 505
AG+ V V D+T PE+L GRVKTLHP
Sbjct: 56 AGVAVTPVDDVTGFPEVLEGRVKTLHP 82
>UniRef50_A2SS05 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=3;
Methanomicrobiales|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase -
Methanocorpusculum labreanum (strain ATCC 43576 / DSM
4855 / Z)
Length = 497
Score = 60.5 bits (140), Expect = 4e-08
Identities = 41/124 (33%), Positives = 63/124 (50%)
Frame = +1
Query: 310 LALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASERRPHSSRCVGHHESTGDARRSG 489
LALLSV DKTG+L LA++L + +++SGGTA E + + +
Sbjct: 3 LALLSVWDKTGILDLARALVAKNIGILSSGGTAKALREAGIPAKDVSEYTQFPEMMDGRV 62
Query: 490 ENFTSSVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADAVENI 669
+ VH G+L R D + MK E I ++ NLYPF + + ++ + + +E I
Sbjct: 63 KTLHPKVHGGLLGR-RGIDDDVMKAHFIEPIDILCVNLYPF--EEMSKKNLPLEELIEFI 119
Query: 670 DIGG 681
DIGG
Sbjct: 120 DIGG 123
Score = 47.6 bits (108), Expect = 3e-04
Identities = 20/32 (62%), Positives = 26/32 (81%)
Frame = +2
Query: 410 RALRNAGLTVQDVSDITRAPEMLGGRVKTLHP 505
+ALR AG+ +DVS+ T+ PEM+ GRVKTLHP
Sbjct: 36 KALREAGIPAKDVSEYTQFPEMMDGRVKTLHP 67
>UniRef50_Q8D244 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=2; Gammaproteobacteria|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Wigglesworthia glossinidia
brevipalpis
Length = 529
Score = 60.5 bits (140), Expect = 4e-08
Identities = 37/125 (29%), Positives = 66/125 (52%)
Frame = +1
Query: 307 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASERRPHSSRCVGHHESTGDARRS 486
+ AL+SVSDKTG+ SLAK+L + ++LI + GT E+ S+ +
Sbjct: 9 RCALISVSDKTGIFSLAKNLIKHKVKLITTSGTYKYLLEKGIFSTSVSEYINHPEIINGR 68
Query: 487 GENFTSSVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADAVEN 666
+ +H GIL+ ++ + + K + I +V+ N YPF+ + ++ + + ++N
Sbjct: 69 VKTLHPKIHGGILS--NNKNINENKNLNIKKIDMVITNFYPFKKK-VKKENIKIENIIDN 125
Query: 667 IDIGG 681
IDIGG
Sbjct: 126 IDIGG 130
>UniRef50_A7I7L2 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=1; Candidatus
Methanoregula boonei 6A8|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Methanoregula
boonei (strain 6A8)
Length = 525
Score = 60.1 bits (139), Expect = 5e-08
Identities = 46/128 (35%), Positives = 64/128 (50%), Gaps = 3/128 (2%)
Frame = +1
Query: 307 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTAT---GASERRPHSSRCVGHHESTGDA 477
K ALLSV DKTG++ LA++L + +++SGGT T GA SR G E D
Sbjct: 32 KWALLSVWDKTGIVDLAQALIQHNFSIMSSGGTGTALAGAGIPFTEVSRYTGFPEMM-DG 90
Query: 478 RRSGENFTSSVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADA 657
R + VH G+L R D M + I ++V NLYPF + R + +
Sbjct: 91 R--VKTLHPKVHGGLLGR-RQIDDAIMAKYGINRIGLLVVNLYPF--ERMSRESLPLEKL 145
Query: 658 VENIDIGG 681
+E ID+GG
Sbjct: 146 IEYIDVGG 153
>UniRef50_Q8XMK2 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=14; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Clostridium perfringens
Length = 501
Score = 60.1 bits (139), Expect = 5e-08
Identities = 44/126 (34%), Positives = 63/126 (50%), Gaps = 1/126 (0%)
Frame = +1
Query: 307 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASERRPHSSRCVGHHESTGDARRS 486
K AL+SV DK G+L LAK L + +++I+SGGT E +
Sbjct: 3 KRALISVFDKDGVLELAKFLRDRDVEIISSGGTYKYLKENNIEVKEISEITDFPEMLDGR 62
Query: 487 GENFTSSVHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADAVE 663
+ VHAGILA R + + ++ ++ I VV NLYPF +R D++ + VE
Sbjct: 63 VKTLHPLVHAGILAIRDNKEHMKTLEEREINTIDYVVVNLYPFFEK--VREDLSFEEKVE 120
Query: 664 NIDIGG 681
IDIGG
Sbjct: 121 FIDIGG 126
Score = 40.7 bits (91), Expect = 0.033
Identities = 18/35 (51%), Positives = 24/35 (68%)
Frame = +2
Query: 416 LRNAGLTVQDVSDITRAPEMLGGRVKTLHPAYMLG 520
L+ + V+++S+IT PEML GRVKTLHP G
Sbjct: 39 LKENNIEVKEISEITDFPEMLDGRVKTLHPLVHAG 73
>UniRef50_A0JTW4 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=2;
Arthrobacter|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Arthrobacter sp.
(strain FB24)
Length = 559
Score = 59.7 bits (138), Expect = 7e-08
Identities = 47/127 (37%), Positives = 61/127 (48%), Gaps = 4/127 (3%)
Frame = +1
Query: 313 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTA---TGASERRPHSSRCVGHHESTGDARR 483
AL+SV DKTGL LAK L E G++++++G TA A G E D R
Sbjct: 14 ALISVYDKTGLEELAKGLHEAGVKIVSTGSTAKKIAAAGIPVQEVEEVTGSPEML-DGR- 71
Query: 484 SGENFTSSVHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADAV 660
+ VH GILA R + E + + E +VV NLYPF ++ D V
Sbjct: 72 -VKTLHPRVHGGILADRRVPAHMETLAGMEIEAFDLVVVNLYPFVET--VKSGAAQDDVV 128
Query: 661 ENIDIGG 681
E IDIGG
Sbjct: 129 EQIDIGG 135
Score = 44.0 bits (99), Expect = 0.003
Identities = 18/27 (66%), Positives = 23/27 (85%)
Frame = +2
Query: 425 AGLTVQDVSDITRAPEMLGGRVKTLHP 505
AG+ VQ+V ++T +PEML GRVKTLHP
Sbjct: 51 AGIPVQEVEEVTGSPEMLDGRVKTLHP 77
>UniRef50_Q9PNY2 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=21; Epsilonproteobacteria|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Campylobacter jejuni
Length = 510
Score = 59.7 bits (138), Expect = 7e-08
Identities = 39/124 (31%), Positives = 58/124 (46%), Gaps = 1/124 (0%)
Frame = +1
Query: 313 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASERRPHSSRCVGHHESTGDARRSGE 492
ALLSVSDK G++ K L G +++++GGT E +S +
Sbjct: 3 ALLSVSDKEGIVEFGKELENLGFEILSTGGTFKLLKENGIKVIEVSDFTKSPELFEGRVK 62
Query: 493 NFTSSVHAGILARLSDSDQ-EDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADAVENI 669
+H GIL + SD + + K + I +V NLYPF+ + D + +ENI
Sbjct: 63 TLHPKIHGGILHKRSDENHIKQAKENEILGIDLVCVNLYPFKKTTIMSDDFD--EIIENI 120
Query: 670 DIGG 681
DIGG
Sbjct: 121 DIGG 124
Score = 41.5 bits (93), Expect = 0.019
Identities = 17/32 (53%), Positives = 24/32 (75%)
Frame = +2
Query: 410 RALRNAGLTVQDVSDITRAPEMLGGRVKTLHP 505
+ L+ G+ V +VSD T++PE+ GRVKTLHP
Sbjct: 35 KLLKENGIKVIEVSDFTKSPELFEGRVKTLHP 66
>UniRef50_Q6L122 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=4; Thermoplasmatales|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Picrophilus torridus
Length = 494
Score = 57.2 bits (132), Expect = 4e-07
Identities = 44/125 (35%), Positives = 67/125 (53%), Gaps = 3/125 (2%)
Frame = +1
Query: 316 LLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASERRPHSSRCVGHHESTG-DARRSGE 492
L+SVSD +GL L + L+ + A+ GT S+ + R + TG D +G
Sbjct: 4 LVSVSDTSGLTDLLRHLNG---DVYATPGTFKFLSDSGIKAKRI---SDITGFDDLLNGR 57
Query: 493 NFT--SSVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADAVEN 666
T +V +GIL+R + + D+KR Y +V+CNLY F + Y+ D ++ D +EN
Sbjct: 58 VKTLHPAVFSGILSRRDEQSEADLKRYNYFDFDIVICNLYNF--ESYI--DKSIEDMIEN 113
Query: 667 IDIGG 681
IDIGG
Sbjct: 114 IDIGG 118
Score = 39.1 bits (87), Expect = 0.099
Identities = 17/35 (48%), Positives = 24/35 (68%)
Frame = +2
Query: 416 LRNAGLTVQDVSDITRAPEMLGGRVKTLHPAYMLG 520
L ++G+ + +SDIT ++L GRVKTLHPA G
Sbjct: 34 LSDSGIKAKRISDITGFDDLLNGRVKTLHPAVFSG 68
>UniRef50_A1IEQ8 Cluster: IMP cyclohydrolase; n=1; Candidatus
Desulfococcus oleovorans Hxd3|Rep: IMP cyclohydrolase -
Candidatus Desulfococcus oleovorans Hxd3
Length = 225
Score = 55.6 bits (128), Expect = 1e-06
Identities = 46/130 (35%), Positives = 61/130 (46%), Gaps = 8/130 (6%)
Frame = +1
Query: 316 LLSVSDKTGLLSLAKSLSECG--LQLIASGGTATGASERRPHSSRCVGHHES--TGDARR 483
L+SVSDKTGL L + + ++GGT E +++ V S TG
Sbjct: 19 LISVSDKTGLEEFVTRLVRINPDVHIFSTGGTYQKIYEIFGSAAKSVLTQVSDYTGQPET 78
Query: 484 SG---ENFTSSVHAGILARL-SDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVA 651
G + ++ G+L ++S DMKR I +VV NLYPF RPDVT
Sbjct: 79 QGGLVKTLDFKIYLGLLTETYNESHARDMKRTGAVAIDMVVVNLYPF-SQTVARPDVTPE 137
Query: 652 DAVENIDIGG 681
A NIDIGG
Sbjct: 138 QARGNIDIGG 147
>UniRef50_Q83GZ1 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=2; Tropheryma whipplei|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Tropheryma whipplei (strain Twist)
(Whipple's bacillus)
Length = 542
Score = 53.2 bits (122), Expect = 6e-06
Identities = 43/129 (33%), Positives = 66/129 (51%), Gaps = 4/129 (3%)
Frame = +1
Query: 307 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTA---TGASERRPHSSRCVGHHESTGDA 477
K AL+SVSDK+GL LA++L+ ++++++G TA G S S G E D
Sbjct: 8 KRALISVSDKSGLADLAEALAAHSVKIVSTGSTAEFIRGVSIPVRDVSEVTGVGELL-DG 66
Query: 478 RRSGENFTSSVHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVAD 654
R + +HA ILA S + +++ + +VV NLYPF + + +D
Sbjct: 67 R--VKTLHPKIHAPILADTTSQMHRAQLQQLGVDAFDLVVVNLYPFF-EISKNSEAEFSD 123
Query: 655 AVENIDIGG 681
+E IDIGG
Sbjct: 124 VIEQIDIGG 132
Score = 39.1 bits (87), Expect = 0.099
Identities = 16/30 (53%), Positives = 22/30 (73%)
Frame = +2
Query: 416 LRNAGLTVQDVSDITRAPEMLGGRVKTLHP 505
+R + V+DVS++T E+L GRVKTLHP
Sbjct: 44 IRGVSIPVRDVSEVTGVGELLDGRVKTLHP 73
>UniRef50_Q89B23 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=2; Buchnera aphidicola (Baizongia
pistaciae)|Rep: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Buchnera aphidicola subsp.
Baizongia pistaciae
Length = 529
Score = 51.6 bits (118), Expect = 2e-05
Identities = 32/125 (25%), Positives = 63/125 (50%)
Frame = +1
Query: 307 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASERRPHSSRCVGHHESTGDARRS 486
K L+SVSD + ++ +KSL ++L A+ GTA + +++ +
Sbjct: 8 KNVLISVSDTSNIIEFSKSLISKNIKLFATKGTANFLKKNNIYATDITNYTNFPEIMNGR 67
Query: 487 GENFTSSVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADAVEN 666
+ ++A ILA+ D++ +++ ++ +VV N YPF + ++ + D +E+
Sbjct: 68 IKTLHHKIYASILAQ-PKHDKKTIEKYNIILMDIVVINFYPFE-EASNNTNLHLNDIIEH 125
Query: 667 IDIGG 681
IDIGG
Sbjct: 126 IDIGG 130
>UniRef50_Q316G8 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=4; Desulfovibrionaceae|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Desulfovibrio desulfuricans (strain
G20)
Length = 252
Score = 50.8 bits (116), Expect = 3e-05
Identities = 41/127 (32%), Positives = 63/127 (49%), Gaps = 4/127 (3%)
Frame = +1
Query: 313 ALLSVSDKTGLLSLAKSLSECGLQLIASGG---TATGASERRPHSSRCVGHHESTGDARR 483
ALLSV+DK+GL+ A L++ G++L+++GG T T A S+ G E G +
Sbjct: 62 ALLSVTDKSGLVEFATFLTQNGVELVSTGGTQRTLTEAGLDVTPVSKVTGFPEIMGGRVK 121
Query: 484 SGENFTSSVHAGILARLSDSDQ-EDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADAV 660
+ +H GILA + + +K ++ NLY F D R + + AV
Sbjct: 122 T---LHPHIHGGILADKDNPEHLATLKELGIRTFDLICVNLYNF-ADAAAR-GLDLRGAV 176
Query: 661 ENIDIGG 681
E +DIGG
Sbjct: 177 EEVDIGG 183
Score = 44.0 bits (99), Expect = 0.003
Identities = 20/32 (62%), Positives = 23/32 (71%)
Frame = +2
Query: 410 RALRNAGLTVQDVSDITRAPEMLGGRVKTLHP 505
R L AGL V VS +T PE++GGRVKTLHP
Sbjct: 94 RTLTEAGLDVTPVSKVTGFPEIMGGRVKTLHP 125
>UniRef50_Q8A155 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=5; Bacteroides|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Bacteroides thetaiotaomicron
Length = 507
Score = 48.8 bits (111), Expect = 1e-04
Identities = 42/129 (32%), Positives = 66/129 (51%), Gaps = 4/129 (3%)
Frame = +1
Query: 307 KLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASERRPHSSRCVGHHESTGDARRS 486
K AL+SV K GL + L E G++ +++GGT E + + V +T +
Sbjct: 8 KTALVSVYHKEGLDEIITKLYEEGVEFLSTGGTRQFI-ESLGYPCKAV-EDLTTYPSILG 65
Query: 487 GENFT--SSVHAGILARLSDSDQEDMKRQKYEM--ISVVVCNLYPFRPDGYLRPDVTVAD 654
G T + GIL R D +Q+ + +KYE+ I +V+ +LYPF + + + AD
Sbjct: 66 GRVKTLHPKIFGGILCR-RDLEQDIQQIEKYEIPEIDLVIVDLYPF--EATVASGASEAD 122
Query: 655 AVENIDIGG 681
+E IDIGG
Sbjct: 123 IIEKIDIGG 131
Score = 36.3 bits (80), Expect = 0.70
Identities = 15/30 (50%), Positives = 20/30 (66%)
Frame = +2
Query: 416 LRNAGLTVQDVSDITRAPEMLGGRVKTLHP 505
+ + G + V D+T P +LGGRVKTLHP
Sbjct: 44 IESLGYPCKAVEDLTTYPSILGGRVKTLHP 73
>UniRef50_Q7VRP9 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase, IMP cyclohydrolase and MGS-like
domain; n=2; Candidatus Blochmannia|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase, IMP cyclohydrolase and MGS-like
domain - Blochmannia floridanus
Length = 549
Score = 45.6 bits (103), Expect = 0.001
Identities = 36/124 (29%), Positives = 62/124 (50%), Gaps = 1/124 (0%)
Frame = +1
Query: 313 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASERRPHSSRCVGHHESTGDARRSGE 492
AL+SV DK+ LL +KSLS G++L+++ GTA + ++ + +
Sbjct: 10 ALISVFDKSNLLHFSKSLSHLGIKLLSTEGTALILTNAGLTVNKISDYTNFPEIMNGQVK 69
Query: 493 NFTSSVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADAV-ENI 669
+ AGIL+R + D+ + + + I +V+ N YPF L+ ++ + E I
Sbjct: 70 TLHHKICAGILSR-KNLDESIIHKYGIQPIDMVIVNFYPFHL--ILQNKQHDSEKILEYI 126
Query: 670 DIGG 681
DIGG
Sbjct: 127 DIGG 130
Score = 41.9 bits (94), Expect = 0.014
Identities = 18/29 (62%), Positives = 22/29 (75%)
Frame = +2
Query: 416 LRNAGLTVQDVSDITRAPEMLGGRVKTLH 502
L NAGLTV +SD T PE++ G+VKTLH
Sbjct: 44 LTNAGLTVNKISDYTNFPEIMNGQVKTLH 72
>UniRef50_Q7MUT5 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=24;
Bacteria|Rep: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Porphyromonas
gingivalis (Bacteroides gingivalis)
Length = 508
Score = 43.6 bits (98), Expect = 0.005
Identities = 36/127 (28%), Positives = 61/127 (48%), Gaps = 4/127 (3%)
Frame = +1
Query: 313 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASERRPHSSRCVGHHESTGDARRSG- 489
AL+SV K GL + L+ G++ +++GGT + ++ R V + T G
Sbjct: 11 ALISVYHKEGLAEILAELNRQGVEFVSTGGTHEFITSLG-YACRAVD--DLTRYPSMLGG 67
Query: 490 --ENFTSSVHAGILARLS-DSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADAV 660
+ + GILAR +SD ++ +I +V+ +LYPF + + + D +
Sbjct: 68 RVKTLHPMIFGGILARRGHESDVREVGEYGLPLIDLVIVDLYPF--EATVASGASEEDII 125
Query: 661 ENIDIGG 681
E IDIGG
Sbjct: 126 EKIDIGG 132
Score = 40.3 bits (90), Expect = 0.043
Identities = 17/30 (56%), Positives = 21/30 (70%)
Frame = +2
Query: 416 LRNAGLTVQDVSDITRAPEMLGGRVKTLHP 505
+ + G + V D+TR P MLGGRVKTLHP
Sbjct: 45 ITSLGYACRAVDDLTRYPSMLGGRVKTLHP 74
>UniRef50_A1G3C3 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=1; Salinispora arenicola
CNS205|Rep: Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Salinispora arenicola CNS205
Length = 190
Score = 42.3 bits (95), Expect = 0.011
Identities = 39/127 (30%), Positives = 57/127 (44%), Gaps = 3/127 (2%)
Frame = +1
Query: 310 LALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASERRPHSSRCVGHHESTGDARRSG 489
LA+L+VSDK + LA L G ++A+ GT R H + G G
Sbjct: 2 LAVLAVSDKRNIEELATGLLGLGWDVVATEGTRRLL---RDHGVTVGAVSDLAGVPTLLG 58
Query: 490 ---ENFTSSVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFRPDGYLRPDVTVADAV 660
+ T S+ GILAR +D+ +++R + +V CN Y PD +P
Sbjct: 59 GRVKTLTVSLMGGILARDEPADRAEVERHGLTRVHLVCCNYYRL-PDP--QPAQPFERFR 115
Query: 661 ENIDIGG 681
E ID+GG
Sbjct: 116 ELIDVGG 122
Score = 39.5 bits (88), Expect = 0.075
Identities = 20/37 (54%), Positives = 25/37 (67%)
Frame = +2
Query: 410 RALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAYMLG 520
R LR+ G+TV VSD+ P +LGGRVKTL + M G
Sbjct: 35 RLLRDHGVTVGAVSDLAGVPTLLGGRVKTLTVSLMGG 71
>UniRef50_Q8G6B1 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=89; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Bifidobacterium longum
Length = 545
Score = 40.3 bits (90), Expect = 0.043
Identities = 18/32 (56%), Positives = 22/32 (68%)
Frame = +2
Query: 410 RALRNAGLTVQDVSDITRAPEMLGGRVKTLHP 505
+ L G+ V +VSD+T PE L GRVKTLHP
Sbjct: 43 KKLAELGVKVTEVSDVTGFPECLDGRVKTLHP 74
>UniRef50_A7PK27 Cluster: Chromosome chr15 scaffold_19, whole genome
shotgun sequence; n=1; Vitis vinifera|Rep: Chromosome
chr15 scaffold_19, whole genome shotgun sequence - Vitis
vinifera (Grape)
Length = 227
Score = 39.1 bits (87), Expect = 0.099
Identities = 30/110 (27%), Positives = 45/110 (40%), Gaps = 1/110 (0%)
Frame = +1
Query: 286 QNMASNGKLALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASERRPHSSRCVGHHES 465
Q+ AS K AL+S+S+K L L SL G ++++ GGT +++
Sbjct: 15 QSTASGNKQALISLSEKNDLAFLGNSLQILGYRIVSFGGTTLALENAWVSTTKVEQLTCF 74
Query: 466 TGDARRSGENFTSSVHAGILARLSDSDQ-EDMKRQKYEMISVVVCNLYPF 612
+ ++ GIL R E + VVV NLYPF
Sbjct: 75 PKILDGHVKTLHPNIQGGILPRRDQKHHMEALNEHGIGTFDVVVVNLYPF 124
Score = 33.5 bits (73), Expect = 4.9
Identities = 15/31 (48%), Positives = 20/31 (64%)
Frame = +2
Query: 413 ALRNAGLTVQDVSDITRAPEMLGGRVKTLHP 505
AL NA ++ V +T P++L G VKTLHP
Sbjct: 57 ALENAWVSTTKVEQLTCFPKILDGHVKTLHP 87
>UniRef50_UPI00006CA722 Cluster: hypothetical protein TTHERM_00842490;
n=1; Tetrahymena thermophila SB210|Rep: hypothetical
protein TTHERM_00842490 - Tetrahymena thermophila SB210
Length = 1945
Score = 36.7 bits (81), Expect = 0.53
Identities = 28/87 (32%), Positives = 43/87 (49%), Gaps = 3/87 (3%)
Frame = +3
Query: 84 KKKKQFFVQLLMLKTL*DIFNFIVYILKKYIKTQXPLDEVKNISDYNN-RLSPPVNPSQV 260
+K K+ F+++ + K L N + L+ YI+T LDE+ I +N SP +P +
Sbjct: 1805 EKNKKSFLRVQLQKKL----NVLNAQLETYIRTTLDLDEIYYILLFNQINSSPSTSPQKP 1860
Query: 261 SYTVVLEQTEHG--VKWKTSSSQRFRQ 335
S+T QT+ G K K Q F Q
Sbjct: 1861 SFTQQFMQTQQGSNSKLKKPEDQSFNQ 1887
>UniRef50_Q9X0X6 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=4; Thermotogaceae|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Thermotoga maritima
Length = 452
Score = 36.7 bits (81), Expect = 0.53
Identities = 17/35 (48%), Positives = 21/35 (60%)
Frame = +2
Query: 416 LRNAGLTVQDVSDITRAPEMLGGRVKTLHPAYMLG 520
L++ G+ DVS IT +LGG VKTLHP G
Sbjct: 38 LKSNGIEANDVSTITGFENLLGGLVKTLHPEIFAG 72
>UniRef50_A5B1A5 Cluster: DNA-directed RNA polymerase; n=1; Vitis
vinifera|Rep: DNA-directed RNA polymerase - Vitis
vinifera (Grape)
Length = 202
Score = 33.5 bits (73), Expect = 4.9
Identities = 15/31 (48%), Positives = 20/31 (64%)
Frame = +2
Query: 413 ALRNAGLTVQDVSDITRAPEMLGGRVKTLHP 505
AL NA ++ V +T P++L G VKTLHP
Sbjct: 57 ALENAWVSTTKVEQLTCFPKILDGHVKTLHP 87
>UniRef50_Q54ZP8 Cluster: Putative homeobox transcription factor;
n=2; Dictyostelium discoideum AX4|Rep: Putative homeobox
transcription factor - Dictyostelium discoideum AX4
Length = 516
Score = 33.1 bits (72), Expect = 6.5
Identities = 21/60 (35%), Positives = 32/60 (53%)
Frame = +1
Query: 388 IASGGTATGASERRPHSSRCVGHHESTGDARRSGENFTSSVHAGILARLSDSDQEDMKRQ 567
I GG G+S R SSR + S+G + SG N +SS++ I SD+D + ++Q
Sbjct: 32 IGGGGGGGGSSSSRSSSSRSSSNRSSSGSSGGSGSNSSSSINNII---NSDNDFKTERKQ 88
>UniRef50_A5KA45 Cluster: Putative uncharacterized protein; n=2;
Plasmodium|Rep: Putative uncharacterized protein -
Plasmodium vivax
Length = 4034
Score = 33.1 bits (72), Expect = 6.5
Identities = 14/26 (53%), Positives = 16/26 (61%)
Frame = +3
Query: 279 EQTEHGVKWKTSSSQRFRQDGSTLVS 356
E HGV WK S SQR+ GST+ S
Sbjct: 3067 EAGHHGVMWKNSLSQRYHNSGSTMHS 3092
>UniRef50_UPI0000382898 Cluster: COG0138: AICAR transformylase/IMP
cyclohydrolase PurH (only IMP cyclohydrolase domain in
Aful); n=1; Magnetospirillum magnetotacticum MS-1|Rep:
COG0138: AICAR transformylase/IMP cyclohydrolase PurH
(only IMP cyclohydrolase domain in Aful) -
Magnetospirillum magnetotacticum MS-1
Length = 50
Score = 32.7 bits (71), Expect = 8.6
Identities = 17/45 (37%), Positives = 24/45 (53%)
Frame = +1
Query: 313 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATGASERRPHSSRC 447
ALLSVSDKTGL A +L G++L+++ S +C
Sbjct: 4 ALLSVSDKTGLTDFAAALIGQGVELVSTAAPIARXHRAGLRSGKC 48
>UniRef50_Q9F5Q0 Cluster: Putative uncharacterized protein; n=1;
Ectothiorhodospira shaposhnikovii|Rep: Putative
uncharacterized protein - Ectothiorhodospira vacuolata
Length = 327
Score = 32.7 bits (71), Expect = 8.6
Identities = 17/46 (36%), Positives = 24/46 (52%), Gaps = 1/46 (2%)
Frame = +1
Query: 379 LQLIASGGTATGASERRPHSSRCVGHHESTG-DARRSGENFTSSVH 513
LQ + GG TGA +RR H+ G+ G +A+ +G FT H
Sbjct: 48 LQALDGGGDGTGAHDRRVHAGGGEGNDAGQGVEAQLAGHGFTHDHH 93
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 622,963,318
Number of Sequences: 1657284
Number of extensions: 12311215
Number of successful extensions: 37504
Number of sequences better than 10.0: 54
Number of HSP's better than 10.0 without gapping: 36183
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 37428
length of database: 575,637,011
effective HSP length: 98
effective length of database: 413,223,179
effective search space used: 53719013270
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
- SilkBase 1999-2023 -