Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fbS20862
(321 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_UPI00015B59A5 Cluster: PREDICTED: similar to ENSANGP000... 139 1e-32
UniRef50_O65271 Cluster: F6N23.26 protein; n=20; Viridiplantae|R... 115 2e-25
UniRef50_P11586 Cluster: C-1-tetrahydrofolate synthase, cytoplas... 113 5e-25
UniRef50_O65269 Cluster: F6N23.28 protein; n=1; Arabidopsis thal... 110 5e-24
UniRef50_Q4T2B9 Cluster: Chromosome undetermined SCAF10300, whol... 108 3e-23
UniRef50_Q8W528 Cluster: Methylenetetrahydrofolate dehydrogenase... 107 6e-23
UniRef50_Q9LHH7 Cluster: 5,10-methylenetetrahydrofolate dehydrog... 97 9e-20
UniRef50_Q21285 Cluster: Dauer or aging adult overexpression pro... 93 1e-18
UniRef50_A1AL91 Cluster: Bifunctional protein folD [Includes: Me... 88 4e-17
UniRef50_Q3YRE3 Cluster: Bifunctional protein folD [Includes: Me... 87 9e-17
UniRef50_Q7MVE9 Cluster: Bifunctional protein folD [Includes: Me... 86 1e-16
UniRef50_A5V1H2 Cluster: Methylenetetrahydrofolate dehydrogenase... 84 5e-16
UniRef50_Q5PBL6 Cluster: Bifunctional protein folD [Includes: Me... 82 3e-15
UniRef50_Q5SJ94 Cluster: Bifunctional protein folD [Includes: Me... 81 6e-15
UniRef50_Q8DMU0 Cluster: Bifunctional protein folD [Includes: Me... 81 6e-15
UniRef50_A7D6I9 Cluster: Methenyltetrahydrofolate cyclohydrolase... 79 1e-14
UniRef50_Q189R8 Cluster: Bifunctional protein folD [Includes: Me... 79 2e-14
UniRef50_Q9A8Y0 Cluster: Bifunctional protein folD [Includes: Me... 78 3e-14
UniRef50_Q8EQ43 Cluster: Bifunctional protein folD [Includes: Me... 77 6e-14
UniRef50_UPI000038C811 Cluster: COG0190: 5,10-methylene-tetrahyd... 77 8e-14
UniRef50_Q8KN38 Cluster: Bifunctional protein folD [Includes: Me... 76 2e-13
UniRef50_A1HML1 Cluster: Methenyltetrahydrofolate cyclohydrolase... 75 3e-13
UniRef50_Q4FNW1 Cluster: Bifunctional protein folD [Includes: Me... 75 3e-13
UniRef50_Q86F84 Cluster: Clone ZZD1003 mRNA sequence; n=1; Schis... 75 4e-13
UniRef50_Q6F9E6 Cluster: Bifunctional protein folD 1 [Includes: ... 74 5e-13
UniRef50_Q7TU81 Cluster: Bifunctional protein folD [Includes: Me... 73 9e-13
UniRef50_Q2B9L0 Cluster: Bifunctional protein FolD; n=1; Bacillu... 72 2e-12
UniRef50_Q8EV80 Cluster: Bifunctional protein folD [Includes: Me... 72 2e-12
UniRef50_Q9HPY4 Cluster: Bifunctional protein folD [Includes: Me... 72 2e-12
UniRef50_Q24UZ7 Cluster: Bifunctional protein folD 2 [Includes: ... 72 2e-12
UniRef50_Q1II76 Cluster: Bifunctional protein folD [Includes: Me... 72 3e-12
UniRef50_Q9X288 Cluster: Bifunctional protein folD [Includes: Me... 71 4e-12
UniRef50_O83714 Cluster: Bifunctional protein folD [Includes: Me... 71 5e-12
UniRef50_Q6D2E6 Cluster: Bifunctional protein folD [Includes: Me... 71 5e-12
UniRef50_Q987T6 Cluster: Bifunctional protein folD 2 [Includes: ... 70 9e-12
UniRef50_Q4FTX6 Cluster: Bifunctional protein folD [Includes: Me... 69 2e-11
UniRef50_Q8RAD0 Cluster: Bifunctional protein folD [Includes: Me... 69 2e-11
UniRef50_P56467 Cluster: Bifunctional protein folD [Includes: Me... 69 3e-11
UniRef50_Q97HC9 Cluster: Bifunctional protein folD [Includes: Me... 69 3e-11
UniRef50_A4M873 Cluster: Tetrahydrofolate dehydrogenase/cyclohyd... 68 4e-11
UniRef50_Q9ZD32 Cluster: Bifunctional protein folD [Includes: Me... 68 5e-11
UniRef50_Q9KQQ6 Cluster: Bifunctional protein folD [Includes: Me... 67 6e-11
UniRef50_Q6ALZ5 Cluster: Bifunctional protein folD [Includes: Me... 66 1e-10
UniRef50_Q16F77 Cluster: Methylenetetrahydrofolate dehydrogenase... 66 2e-10
UniRef50_Q14NV1 Cluster: Bifunctional protein folD [Includes: Me... 66 2e-10
UniRef50_Q057D7 Cluster: Bifunctional protein folD [Includes: Me... 65 3e-10
UniRef50_Q3AYX2 Cluster: Bifunctional protein folD [Includes: Me... 64 4e-10
UniRef50_A3PVV6 Cluster: Bifunctional protein folD [Includes: Me... 64 4e-10
UniRef50_A6LP88 Cluster: Tetrahydrofolate dehydrogenase/cyclohyd... 64 8e-10
UniRef50_Q5FJG5 Cluster: Bifunctional protein folD [Includes: Me... 64 8e-10
UniRef50_Q6MI74 Cluster: Bifunctional protein folD [Includes: Me... 64 8e-10
UniRef50_Q74J95 Cluster: Bifunctional protein folD 1 [Includes: ... 64 8e-10
UniRef50_Q8RDM4 Cluster: Bifunctional protein folD [Includes: Me... 63 1e-09
UniRef50_UPI000065DF90 Cluster: methylenetetrahydrofolate dehydr... 63 1e-09
UniRef50_UPI00006CCCC6 Cluster: methylenetetrahydrofolate dehydr... 62 2e-09
UniRef50_Q63SL6 Cluster: Bifunctional protein folD [Includes: Me... 62 2e-09
UniRef50_Q6L046 Cluster: Bifunctional protein folD [Includes: Me... 62 3e-09
UniRef50_A0C3Q0 Cluster: Chromosome undetermined scaffold_147, w... 61 5e-09
UniRef50_Q2JCX4 Cluster: Bifunctional protein folD 1 [Includes: ... 61 5e-09
UniRef50_UPI00015B49ED Cluster: PREDICTED: similar to putative g... 60 9e-09
UniRef50_A0DMT9 Cluster: Chromosome undetermined scaffold_57, wh... 60 1e-08
UniRef50_Q83FS2 Cluster: Bifunctional protein folD [Includes: Me... 60 1e-08
UniRef50_Q979W3 Cluster: Bifunctional protein folD [Includes: Me... 60 1e-08
UniRef50_Q0AWX5 Cluster: Bifunctional protein folD 2 [Includes: ... 58 3e-08
UniRef50_Q0SFQ8 Cluster: Bifunctional protein folD 1 [Includes: ... 58 3e-08
UniRef50_Q54VK0 Cluster: Methenyl tetrahydrofolate cyclohydrolas... 58 4e-08
UniRef50_A7DNA7 Cluster: Methylenetetrahydrofolate dehydrogenase... 58 5e-08
UniRef50_O84081 Cluster: Bifunctional protein folD [Includes: Me... 58 5e-08
UniRef50_UPI0000DB7ABF Cluster: PREDICTED: similar to Bifunction... 57 9e-08
UniRef50_Q8TK95 Cluster: Bifunctional protein folD [Includes: Me... 55 3e-07
UniRef50_P13995 Cluster: Bifunctional methylenetetrahydrofolate ... 55 4e-07
UniRef50_A0JTZ0 Cluster: Bifunctional protein folD [Includes: Me... 55 4e-07
UniRef50_Q6F1V0 Cluster: Bifunctional protein folD [Includes: Me... 54 8e-07
UniRef50_A4EAK0 Cluster: Putative uncharacterized protein; n=3; ... 53 1e-06
UniRef50_Q74GN1 Cluster: Bifunctional protein folD 1 [Includes: ... 52 3e-06
UniRef50_Q6BNW9 Cluster: Debaryomyces hansenii chromosome E of s... 50 1e-05
UniRef50_Q3A1Q7 Cluster: Bifunctional protein folD [Includes: Me... 50 1e-05
UniRef50_Q9RW02 Cluster: Bifunctional protein folD [Includes: Me... 48 3e-05
UniRef50_Q4DH06 Cluster: Methylenetetrahydrofolate dehydrogenase... 48 4e-05
UniRef50_A5CF58 Cluster: Bifunctional protein folD [Includes: Me... 47 7e-05
UniRef50_A6NP56 Cluster: Uncharacterized protein ENSP00000372121... 47 9e-05
UniRef50_O51057 Cluster: Bifunctional protein folD [Includes: Me... 46 1e-04
UniRef50_UPI00005A5066 Cluster: PREDICTED: similar to Bifunction... 46 2e-04
UniRef50_Q6LEW8 Cluster: Putative uncharacterized protein; n=1; ... 45 4e-04
UniRef50_Q1AVQ0 Cluster: Bifunctional protein folD 2 [Includes: ... 44 7e-04
UniRef50_UPI00006CB712 Cluster: tetrahydrofolate dehydrogenase/c... 43 0.001
UniRef50_Q04FB7 Cluster: Bifunctional protein folD [Includes: Me... 42 0.003
UniRef50_Q7NAE4 Cluster: Bifunctional protein folD [Includes: Me... 42 0.003
UniRef50_A5K2D8 Cluster: Putative uncharacterized protein; n=1; ... 41 0.005
UniRef50_Q8ZZK1 Cluster: Bifunctional protein folD [Includes: Me... 39 0.019
UniRef50_Q4A6B1 Cluster: Bifunctional protein folD [Includes: Me... 39 0.019
UniRef50_Q6KID0 Cluster: Bifunctional protein folD [Includes: Me... 39 0.025
UniRef50_A5IXS7 Cluster: FolD bifunctional protein; n=1; Mycopla... 38 0.043
UniRef50_Q6FWY6 Cluster: Candida glabrata strain CBS138 chromoso... 34 0.70
UniRef50_Q6G585 Cluster: Sensor protein; n=3; Bartonella|Rep: Se... 33 1.2
UniRef50_A0T555 Cluster: Ornithine cyclodeaminase/mu-crystallin;... 33 1.6
UniRef50_Q4S6Y9 Cluster: Chromosome 14 SCAF14723, whole genome s... 32 2.1
UniRef50_Q221W9 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 32 2.1
UniRef50_Q5H851 Cluster: Putative uncharacterized protein; n=1; ... 32 2.8
UniRef50_Q12DQ7 Cluster: Ornithine cyclodeaminase/mu-crystallin;... 32 2.8
UniRef50_A4H5B9 Cluster: Putative uncharacterized protein; n=1; ... 31 3.7
UniRef50_A7D849 Cluster: Metal-dependent phosphohydrolase, HD su... 31 3.7
UniRef50_UPI0000F21FF3 Cluster: PREDICTED: similar to ZNF336; n=... 31 4.9
UniRef50_A7DIP1 Cluster: Diguanylate cyclase/phosphodiesterase w... 31 4.9
UniRef50_A4AHV5 Cluster: Putative uncharacterized protein; n=1; ... 31 4.9
UniRef50_Q4DSZ0 Cluster: Putative uncharacterized protein; n=3; ... 31 4.9
UniRef50_Q7S326 Cluster: Putative uncharacterized protein NCU091... 31 4.9
UniRef50_Q6YQB8 Cluster: ABC-type amino acid transport system, p... 31 6.5
UniRef50_A5D4V4 Cluster: Trehalose-6-phosphate synthase; n=1; Pe... 31 6.5
UniRef50_A4Z040 Cluster: Putative branched-chain amino acid ABC ... 31 6.5
UniRef50_A1ZUI3 Cluster: Tetrahydrofolate dehydrogenase/cyclohyd... 31 6.5
UniRef50_A1UHY6 Cluster: Cytochrome P450; n=5; Mycobacterium|Rep... 31 6.5
UniRef50_A2WN32 Cluster: Putative uncharacterized protein; n=2; ... 31 6.5
UniRef50_Q2UFW7 Cluster: Predicted protein; n=2; Trichocomaceae|... 31 6.5
UniRef50_UPI0000DD7AFF Cluster: PREDICTED: hypothetical protein;... 30 8.6
UniRef50_Q19Z55 Cluster: Gp31; n=3; Viruses|Rep: Gp31 - Mycobact... 30 8.6
UniRef50_P20129 Cluster: 70 kDa protein; n=1; Eggplant mosaic vi... 30 8.6
UniRef50_Q6NRM6 Cluster: DNA replication licensing factor MCM9; ... 30 8.6
>UniRef50_UPI00015B59A5 Cluster: PREDICTED: similar to
ENSANGP00000016878; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000016878 - Nasonia
vitripennis
Length = 866
Score = 139 bits (337), Expect = 1e-32
Identities = 63/84 (75%), Positives = 73/84 (86%)
Frame = +3
Query: 3 ELLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIE 182
ELLKW +ATVTVCHS+TK+L + A+I+VV IG+PE+V+GSWIKPGAVVIDCGIN+I
Sbjct: 185 ELLKWHNATVTVCHSRTKDLPSVVSKADIVVVGIGQPELVKGSWIKPGAVVIDCGINSIP 244
Query: 183 DPTKKSGQRLVGDVAYQEAVKVAS 254
DPTKKSGQRLVGDV Y EA KVAS
Sbjct: 245 DPTKKSGQRLVGDVDYAEAAKVAS 268
Score = 42.3 bits (95), Expect = 0.002
Identities = 17/20 (85%), Positives = 19/20 (95%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRNT 316
+TPVPGG GPMTVAMLM+NT
Sbjct: 270 ITPVPGGVGPMTVAMLMKNT 289
>UniRef50_O65271 Cluster: F6N23.26 protein; n=20; Viridiplantae|Rep:
F6N23.26 protein - Arabidopsis thaliana (Mouse-ear
cress)
Length = 360
Score = 115 bits (277), Expect = 2e-25
Identities = 52/83 (62%), Positives = 67/83 (80%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
LL+ E ATV++ HS+TKN EIT+ A+I++ A+G+P MVRGSWIKPGAV+ID GIN +ED
Sbjct: 246 LLQREDATVSIIHSRTKNPEEITREADIIISAVGQPNMVRGSWIKPGAVLIDVGINPVED 305
Query: 186 PTKKSGQRLVGDVAYQEAVKVAS 254
P+ G RLVGD+ Y+EA KVAS
Sbjct: 306 PSAARGYRLVGDICYEEASKVAS 328
Score = 41.1 bits (92), Expect = 0.005
Identities = 16/21 (76%), Positives = 19/21 (90%)
Frame = +2
Query: 254 AVTPVPGGXGPMTVAMLMRNT 316
A+TPVPGG GPMT+AML+ NT
Sbjct: 329 AITPVPGGVGPMTIAMLLSNT 349
>UniRef50_P11586 Cluster: C-1-tetrahydrofolate synthase, cytoplasmic
(C1-THF synthase) [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate
synthetase (EC 6.3.4.3)]; n=86; cellular organisms|Rep:
C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF
synthase) [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate
synthetase (EC 6.3.4.3)] - Homo sapiens (Human)
Length = 935
Score = 113 bits (273), Expect = 5e-25
Identities = 51/84 (60%), Positives = 64/84 (76%)
Frame = +3
Query: 3 ELLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIE 182
+LL W +ATVT CHSKT +L E +ILVVA G+PEMV+G WIKPGA+VIDCGIN +
Sbjct: 183 DLLLWNNATVTTCHSKTAHLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINYVP 242
Query: 183 DPTKKSGQRLVGDVAYQEAVKVAS 254
D K +G+++VGDVAY EA + AS
Sbjct: 243 DDKKPNGRKVVGDVAYDEAKERAS 266
Score = 40.3 bits (90), Expect = 0.008
Identities = 18/25 (72%), Positives = 23/25 (92%)
Frame = +2
Query: 242 QSSFAVTPVPGGXGPMTVAMLMRNT 316
++SF +TPVPGG GPMTVAMLM++T
Sbjct: 264 RASF-ITPVPGGVGPMTVAMLMQST 287
>UniRef50_O65269 Cluster: F6N23.28 protein; n=1; Arabidopsis
thaliana|Rep: F6N23.28 protein - Arabidopsis thaliana
(Mouse-ear cress)
Length = 310
Score = 110 bits (265), Expect = 5e-24
Identities = 49/83 (59%), Positives = 65/83 (78%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
LL+ E ATV++ HS+T N E+T+ A+IL+ A+G+P MVRGSWIKPGAV+ID GI +ED
Sbjct: 196 LLQKEDATVSIIHSRTMNPEELTRQADILISAVGKPNMVRGSWIKPGAVLIDVGIKPVED 255
Query: 186 PTKKSGQRLVGDVAYQEAVKVAS 254
P+ G+RLVGD+ Y EA K+AS
Sbjct: 256 PSAAGGERLVGDICYVEASKIAS 278
Score = 38.3 bits (85), Expect = 0.033
Identities = 15/21 (71%), Positives = 18/21 (85%)
Frame = +2
Query: 254 AVTPVPGGXGPMTVAMLMRNT 316
A+TPVPG GPMT+AML+ NT
Sbjct: 279 AITPVPGDVGPMTIAMLLSNT 299
>UniRef50_Q4T2B9 Cluster: Chromosome undetermined SCAF10300, whole
genome shotgun sequence; n=6; Clupeocephala|Rep:
Chromosome undetermined SCAF10300, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 348
Score = 108 bits (259), Expect = 3e-23
Identities = 50/79 (63%), Positives = 58/79 (73%)
Frame = +3
Query: 3 ELLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIE 182
+LL W HATVT CHSKT +L E A+ILVV GR EMVRG W+K GAVVIDCGIN +
Sbjct: 229 DLLLWNHATVTTCHSKTPDLPEQVGRADILVVGAGRAEMVRGEWLKEGAVVIDCGINQVP 288
Query: 183 DPTKKSGQRLVGDVAYQEA 239
D T+ SG+R+VGDV Y A
Sbjct: 289 DCTRASGKRVVGDVHYASA 307
Score = 41.9 bits (94), Expect = 0.003
Identities = 17/20 (85%), Positives = 19/20 (95%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRNT 316
+TPVPGG GPMTVAMLM+NT
Sbjct: 314 ITPVPGGVGPMTVAMLMQNT 333
>UniRef50_Q8W528 Cluster: Methylenetetrahydrofolate
dehydrogenase/methylenetetrahydrofolate cylcohydrolase
isoform 1; n=11; Viridiplantae|Rep:
Methylenetetrahydrofolate
dehydrogenase/methylenetetrahydrofolate cylcohydrolase
isoform 1 - Zea mays (Maize)
Length = 160
Score = 107 bits (256), Expect = 6e-23
Identities = 49/82 (59%), Positives = 63/82 (76%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
LL E ATVT+ HS+TK +I + A+I++ A G+ M++GSWIKPGA VID G NA++D
Sbjct: 64 LLLKEDATVTIVHSRTKEPEKIVREADIIIAAAGQAMMIKGSWIKPGAAVIDVGTNAVDD 123
Query: 186 PTKKSGQRLVGDVAYQEAVKVA 251
PT+KSG RLVGDV +QEA KVA
Sbjct: 124 PTRKSGYRLVGDVDFQEACKVA 145
>UniRef50_Q9LHH7 Cluster: 5,10-methylenetetrahydrofolate
dehydrogenase/5,10- methenyltetrahydrofolate
cyclohydrolase; n=7; Eukaryota|Rep:
5,10-methylenetetrahydrofolate dehydrogenase/5,10-
methenyltetrahydrofolate cyclohydrolase - Arabidopsis
thaliana (Mouse-ear cress)
Length = 299
Score = 96.7 bits (230), Expect = 9e-20
Identities = 47/82 (57%), Positives = 60/82 (73%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
LLK + ATVT HS TK+ I + A+I++ A G+ M++G+WIKPGA VID G NA+ D
Sbjct: 187 LLKAD-ATVTTVHSHTKDPEAIIREADIVIAACGQAHMIKGNWIKPGAAVIDVGTNAVSD 245
Query: 186 PTKKSGQRLVGDVAYQEAVKVA 251
P+KKSG RLVGDV + EA KVA
Sbjct: 246 PSKKSGYRLVGDVDFAEASKVA 267
Score = 42.3 bits (95), Expect = 0.002
Identities = 17/20 (85%), Positives = 19/20 (95%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRNT 316
+TPVPGG GPMTVAML+RNT
Sbjct: 270 ITPVPGGVGPMTVAMLLRNT 289
>UniRef50_Q21285 Cluster: Dauer or aging adult overexpression
protein 3; n=2; Caenorhabditis|Rep: Dauer or aging adult
overexpression protein 3 - Caenorhabditis elegans
Length = 303
Score = 93.1 bits (221), Expect = 1e-18
Identities = 44/82 (53%), Positives = 55/82 (67%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
L W H TVT+CHSKT NL E A+IL+VAIGR V+ WIKPGA VIDCGIN +D
Sbjct: 186 LFLWHHGTVTICHSKTPNLKEKCLRADILIVAIGRKHFVKADWIKPGAFVIDCGINVGDD 245
Query: 186 PTKKSGQRLVGDVAYQEAVKVA 251
P + +++ GDV + A +VA
Sbjct: 246 P---NSRKIYGDVDTEAAKEVA 264
Score = 41.1 bits (92), Expect = 0.005
Identities = 17/20 (85%), Positives = 19/20 (95%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRNT 316
+TPVPGG GPMTVAML+RNT
Sbjct: 267 LTPVPGGVGPMTVAMLIRNT 286
>UniRef50_A1AL91 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=9; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Pelobacter propionicus (strain DSM 2379)
Length = 283
Score = 87.8 bits (208), Expect = 4e-17
Identities = 39/79 (49%), Positives = 59/79 (74%)
Frame = +3
Query: 18 EHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKK 197
EHATVT+CHS+T++L ++ + A++++ A+GRPEM++G WIK GAVVID GIN + +
Sbjct: 180 EHATVTLCHSRTRDLPDVVRRADVVIAAVGRPEMIKGDWIKEGAVVIDVGINRVGE---- 235
Query: 198 SGQRLVGDVAYQEAVKVAS 254
++LVGDV + A + AS
Sbjct: 236 --KKLVGDVEFAGASQRAS 252
Score = 44.0 bits (99), Expect = 7e-04
Identities = 17/28 (60%), Positives = 22/28 (78%)
Frame = +2
Query: 233 GGGQSSFAVTPVPGGXGPMTVAMLMRNT 316
G Q + A+TPVPGG GPMT+ ML++NT
Sbjct: 246 GASQRASAITPVPGGVGPMTITMLLQNT 273
>UniRef50_Q3YRE3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Proteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Ehrlichia canis (strain Jake)
Length = 300
Score = 86.6 bits (205), Expect = 9e-17
Identities = 44/83 (53%), Positives = 56/83 (67%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
LL E+ TVT HS T+NLS+ A+ILV A+G P V+ SWIKPGA+VID GIN++E+
Sbjct: 180 LLLGENCTVTTVHSATRNLSDYCSKADILVAAVGIPNFVKSSWIKPGAIVIDVGINSVEE 239
Query: 186 PTKKSGQRLVGDVAYQEAVKVAS 254
K + VGDV + EA VAS
Sbjct: 240 DGVK---KFVGDVNFAEAKNVAS 259
Score = 39.5 bits (88), Expect = 0.014
Identities = 16/21 (76%), Positives = 18/21 (85%)
Frame = +2
Query: 254 AVTPVPGGXGPMTVAMLMRNT 316
A+TPVPGG GPMT+A LM NT
Sbjct: 260 AITPVPGGVGPMTIAFLMVNT 280
>UniRef50_Q7MVE9 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=52; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Porphyromonas gingivalis (Bacteroides gingivalis)
Length = 296
Score = 86.2 bits (204), Expect = 1e-16
Identities = 35/76 (46%), Positives = 51/76 (67%)
Frame = +3
Query: 27 TVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKSGQ 206
T+T+CHS+T N+ E+ TA+I++ A+G+PE + +KPGAVV+D G + D T+KSG
Sbjct: 191 TITICHSRTPNIKEVCLTADIIIAALGQPEFLTADMVKPGAVVVDVGTTLVPDSTRKSGF 250
Query: 207 RLVGDVAYQEAVKVAS 254
RL GDV + E S
Sbjct: 251 RLTGDVKFDEVAPKCS 266
Score = 36.7 bits (81), Expect = 0.100
Identities = 14/20 (70%), Positives = 16/20 (80%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRNT 316
+TPVPGG GPMT+ LM NT
Sbjct: 268 ITPVPGGVGPMTIVSLMSNT 287
>UniRef50_A5V1H2 Cluster: Methylenetetrahydrofolate dehydrogenase
(NADP(+)); n=5; Chloroflexi (class)|Rep:
Methylenetetrahydrofolate dehydrogenase (NADP(+)) -
Roseiflexus sp. RS-1
Length = 288
Score = 84.2 bits (199), Expect = 5e-16
Identities = 40/83 (48%), Positives = 58/83 (69%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
LL EHATVT+ HS+TK+L+ + ++A+I+V A G+P ++ G +KPGAVV+D G+N +ED
Sbjct: 178 LLLNEHATVTIAHSRTKDLAAVVRSADIVVAATGKPGLITGDMVKPGAVVVDFGVNVLED 237
Query: 186 PTKKSGQRLVGDVAYQEAVKVAS 254
R+VGDV + V VAS
Sbjct: 238 ------GRVVGDVDFDSVVNVAS 254
Score = 35.9 bits (79), Expect = 0.17
Identities = 14/20 (70%), Positives = 17/20 (85%)
Frame = +2
Query: 254 AVTPVPGGXGPMTVAMLMRN 313
A+TPVPGG GP+T ML+RN
Sbjct: 255 AITPVPGGTGPVTNVMLLRN 274
>UniRef50_Q5PBL6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Alphaproteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Anaplasma marginale (strain St. Maries)
Length = 299
Score = 81.8 bits (193), Expect = 3e-15
Identities = 38/76 (50%), Positives = 53/76 (69%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
LL +E+ TVTV HS ++NL E A+I+V A+G+ +R SWIKPGA+V+D GIN +E+
Sbjct: 178 LLLYENCTVTVLHSASRNLEEHCLRADIIVAAVGKARFIRASWIKPGAIVVDVGINLVEE 237
Query: 186 PTKKSGQRLVGDVAYQ 233
KK R VGDV ++
Sbjct: 238 SGKK---RFVGDVEFE 250
Score = 37.5 bits (83), Expect = 0.057
Identities = 15/21 (71%), Positives = 18/21 (85%)
Frame = +2
Query: 254 AVTPVPGGXGPMTVAMLMRNT 316
+VTPVPGG GPMT+A L+ NT
Sbjct: 258 SVTPVPGGVGPMTIAFLLVNT 278
>UniRef50_Q5SJ94 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermus thermophilus|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermus thermophilus (strain HB8 / ATCC
27634 / DSM 579)
Length = 282
Score = 80.6 bits (190), Expect = 6e-15
Identities = 40/82 (48%), Positives = 58/82 (70%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
LL E ATVT+ HSKT++L E+T+ A++LVVA+GRP +VR W++ GA+V+D G+N +E
Sbjct: 174 LLLREDATVTLAHSKTQDLPEVTRRAQVLVVAVGRPHLVRKEWVREGAIVVDVGVNRVEG 233
Query: 186 PTKKSGQRLVGDVAYQEAVKVA 251
RL+GDV + E +VA
Sbjct: 234 -------RLLGDV-HPEVAEVA 247
Score = 45.2 bits (102), Expect = 3e-04
Identities = 20/29 (68%), Positives = 23/29 (79%)
Frame = +2
Query: 230 PGGGQSSFAVTPVPGGXGPMTVAMLMRNT 316
P + +FA+TPVPGG GPMTVAMLM NT
Sbjct: 241 PEVAEVAFALTPVPGGVGPMTVAMLMGNT 269
>UniRef50_Q8DMU0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=90; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Synechococcus elongatus (Thermosynechococcus
elongatus)
Length = 306
Score = 80.6 bits (190), Expect = 6e-15
Identities = 41/78 (52%), Positives = 55/78 (70%)
Frame = +3
Query: 21 HATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKS 200
+ATVT+ HS+++ L+ IT++AEILV A+G+P + I+PGAVVID GIN I+ P KS
Sbjct: 186 NATVTIAHSRSRELASITRSAEILVTAMGQPRRITADMIRPGAVVIDVGINRIQRPDGKS 245
Query: 201 GQRLVGDVAYQEAVKVAS 254
L GDV Y+ A VAS
Sbjct: 246 S--LWGDVDYEAARAVAS 261
Score = 40.3 bits (90), Expect = 0.008
Identities = 16/20 (80%), Positives = 18/20 (90%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRNT 316
+TPVPGG GPMTVAML+ NT
Sbjct: 263 ITPVPGGVGPMTVAMLLHNT 282
>UniRef50_A7D6I9 Cluster: Methenyltetrahydrofolate cyclohydrolase;
n=1; Halorubrum lacusprofundi ATCC 49239|Rep:
Methenyltetrahydrofolate cyclohydrolase - Halorubrum
lacusprofundi ATCC 49239
Length = 307
Score = 79.4 bits (187), Expect = 1e-14
Identities = 38/77 (49%), Positives = 53/77 (68%)
Frame = +3
Query: 21 HATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKS 200
+AT TVCHS+T++L TA+I++ A+G PE + GS +K GA VID GIN ++ T+K
Sbjct: 195 NATTTVCHSRTRDLEGKLATADIVIAAVGVPEFIDGSMLKEGATVIDVGINRVDADTEK- 253
Query: 201 GQRLVGDVAYQEAVKVA 251
G LVGDV Y+ A + A
Sbjct: 254 GYALVGDVEYESAKEAA 270
Score = 38.7 bits (86), Expect = 0.025
Identities = 16/25 (64%), Positives = 21/25 (84%)
Frame = +2
Query: 242 QSSFAVTPVPGGXGPMTVAMLMRNT 316
+++ A+TPVPGG GPMT AML+ NT
Sbjct: 268 EAAGAITPVPGGVGPMTRAMLLYNT 292
>UniRef50_Q189R8 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=11; Clostridiales|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Clostridium difficile (strain 630)
Length = 290
Score = 78.6 bits (185), Expect = 2e-14
Identities = 37/60 (61%), Positives = 46/60 (76%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
LL EHATVT+CHSKTKNLS + A++L+ AIGR +MV S++K GAVVID GIN E+
Sbjct: 183 LLLSEHATVTICHSKTKNLSGVAAEADVLIAAIGRAKMVDESFVKDGAVVIDVGINVDEE 242
>UniRef50_Q9A8Y0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=82; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Caulobacter crescentus (Caulobacter
vibrioides)
Length = 297
Score = 78.2 bits (184), Expect = 3e-14
Identities = 40/87 (45%), Positives = 56/87 (64%), Gaps = 4/87 (4%)
Frame = +3
Query: 3 ELLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAI- 179
++L TVT+ HS++++L I + A+I+V A+GR EMV+ W+KPGAVVID GI
Sbjct: 178 QMLLAADCTVTIAHSRSQDLPSIVRQADIVVAAVGRAEMVKADWVKPGAVVIDVGITRFP 237
Query: 180 -EDPTKKSG--QRLVGDVAYQEAVKVA 251
DP + RLVGDVA+ E +VA
Sbjct: 238 ARDPEAAAAGKTRLVGDVAFDEVREVA 264
Score = 38.7 bits (86), Expect = 0.025
Identities = 15/21 (71%), Positives = 18/21 (85%)
Frame = +2
Query: 254 AVTPVPGGXGPMTVAMLMRNT 316
A+TPVPGG GPMT+A L+ NT
Sbjct: 266 AITPVPGGVGPMTIACLLANT 286
>UniRef50_Q8EQ43 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=45; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Oceanobacillus iheyensis
Length = 285
Score = 77.4 bits (182), Expect = 6e-14
Identities = 43/83 (51%), Positives = 54/83 (65%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
LL E+ATVT HS+TKNL EITK A+IL+VAIGR + +IK AVVID GIN
Sbjct: 176 LLLQENATVTYTHSRTKNLQEITKQADILIVAIGRAHAINADYIKEDAVVIDVGIN---- 231
Query: 186 PTKKSGQRLVGDVAYQEAVKVAS 254
+K +L GDV ++ A + AS
Sbjct: 232 --RKDDGKLTGDVDFESAEQKAS 252
Score = 36.7 bits (81), Expect = 0.100
Identities = 14/25 (56%), Positives = 19/25 (76%)
Frame = +2
Query: 242 QSSFAVTPVPGGXGPMTVAMLMRNT 316
Q + +TPVP G GPMT+ ML++NT
Sbjct: 249 QKASYITPVPRGVGPMTITMLLKNT 273
>UniRef50_UPI000038C811 Cluster: COG0190:
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl
tetrahydrofolate cyclohydrolase; n=1; Nostoc punctiforme
PCC 73102|Rep: COG0190: 5,10-methylene-tetrahydrofolate
dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase -
Nostoc punctiforme PCC 73102
Length = 292
Score = 77.0 bits (181), Expect = 8e-14
Identities = 35/76 (46%), Positives = 52/76 (68%)
Frame = +3
Query: 24 ATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKSG 203
ATVT+ HS++ +L IT+ A+IL+ A GRP ++ +KPGAVV+D G+N + D + KS
Sbjct: 187 ATVTIAHSRSHDLKSITQNADILIAAAGRPGLITADMVKPGAVVVDVGMNRVTDASGKS- 245
Query: 204 QRLVGDVAYQEAVKVA 251
RL+GDV ++ VA
Sbjct: 246 -RLIGDVDFESTAGVA 260
Score = 39.1 bits (87), Expect = 0.019
Identities = 15/20 (75%), Positives = 19/20 (95%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRNT 316
+TPVPGG GPMTVA+L++NT
Sbjct: 263 ITPVPGGVGPMTVAILLQNT 282
>UniRef50_Q8KN38 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Sphingobium chlorophenolicum|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Sphingobium
chlorophenolicum
Length = 316
Score = 75.8 bits (178), Expect = 2e-13
Identities = 39/77 (50%), Positives = 51/77 (66%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
LL + TVTVC T+NL+E+ + A+I+V A G P +V+G W+K GAVVID GIN I
Sbjct: 177 LLLEQGCTVTVCGRHTRNLAEVCRNADIIVAAAGTPHLVKGYWVKAGAVVIDVGINRIAL 236
Query: 186 PTKKSGQRLVGDVAYQE 236
+S R+VGDVA E
Sbjct: 237 DDGRS--RIVGDVASDE 251
Score = 32.3 bits (70), Expect = 2.1
Identities = 13/17 (76%), Positives = 14/17 (82%)
Frame = +2
Query: 254 AVTPVPGGXGPMTVAML 304
A TPVPGG GPMT+A L
Sbjct: 257 AFTPVPGGVGPMTIACL 273
>UniRef50_A1HML1 Cluster: Methenyltetrahydrofolate cyclohydrolase;
n=1; Thermosinus carboxydivorans Nor1|Rep:
Methenyltetrahydrofolate cyclohydrolase - Thermosinus
carboxydivorans Nor1
Length = 279
Score = 74.9 bits (176), Expect = 3e-13
Identities = 36/82 (43%), Positives = 54/82 (65%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
LL ++ATVTVCHSKT++L+ +T+ A+++V A+GRP ++ ++PGAVVID GIN +
Sbjct: 176 LLLGQNATVTVCHSKTRDLAALTRQADVIVAAVGRPALIGPDMVRPGAVVIDVGINEVNG 235
Query: 186 PTKKSGQRLVGDVAYQEAVKVA 251
+VGDV Y +A
Sbjct: 236 -------AVVGDVDYDAVFPIA 250
>UniRef50_Q4FNW1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Pelagibacter ubique
Length = 281
Score = 74.9 bits (176), Expect = 3e-13
Identities = 39/83 (46%), Positives = 54/83 (65%)
Frame = +3
Query: 3 ELLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIE 182
+LL E+ TVT+ HSKTK+L A+I+V A+G PE+V+ W+K A+VID GIN
Sbjct: 175 QLLLKENCTVTITHSKTKDLKAECLEADIIVAAVGIPELVKADWVKKDAIVIDVGIN--- 231
Query: 183 DPTKKSGQRLVGDVAYQEAVKVA 251
K+ +VGDVA++E KVA
Sbjct: 232 ----KTENGIVGDVAFEEVSKVA 250
Score = 39.1 bits (87), Expect = 0.019
Identities = 15/21 (71%), Positives = 19/21 (90%)
Frame = +2
Query: 254 AVTPVPGGXGPMTVAMLMRNT 316
A+TPVPGG GPMT+A L++NT
Sbjct: 252 ALTPVPGGVGPMTIACLLKNT 272
>UniRef50_Q86F84 Cluster: Clone ZZD1003 mRNA sequence; n=1;
Schistosoma japonicum|Rep: Clone ZZD1003 mRNA sequence -
Schistosoma japonicum (Blood fluke)
Length = 332
Score = 74.5 bits (175), Expect = 4e-13
Identities = 29/76 (38%), Positives = 47/76 (61%)
Frame = +3
Query: 24 ATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKSG 203
ATV CH ++ N+ E +I++ +G P +++G W++PGA+VIDCG + + DP S
Sbjct: 199 ATVIQCHLQSANIDEEINRGDIIISGVGHPGLIKGDWVRPGALVIDCGYSVMNDPQNPSK 258
Query: 204 QRLVGDVAYQEAVKVA 251
R GDV + A++ A
Sbjct: 259 SRCFGDVEFNTALEKA 274
Score = 37.9 bits (84), Expect = 0.043
Identities = 14/20 (70%), Positives = 18/20 (90%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRNT 316
+TPVPGG GP+++AML RNT
Sbjct: 277 ITPVPGGVGPVSIAMLFRNT 296
>UniRef50_Q6F9E6 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Proteobacteria|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Acinetobacter sp. (strain ADP1)
Length = 297
Score = 74.1 bits (174), Expect = 5e-13
Identities = 38/83 (45%), Positives = 55/83 (66%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
LL E TVTV HSKT+N+ ++ + A+I+V A+G+ M+ S++K AVVID GIN I
Sbjct: 186 LLLKESCTVTVVHSKTRNIEQVCQQADIVVAAVGKANMINASYLKADAVVIDVGINRIMT 245
Query: 186 PTKKSGQRLVGDVAYQEAVKVAS 254
K RLVGDV +++A+ + S
Sbjct: 246 HEK---TRLVGDVDFEDALPMVS 265
Score = 41.1 bits (92), Expect = 0.005
Identities = 16/21 (76%), Positives = 19/21 (90%)
Frame = +2
Query: 254 AVTPVPGGXGPMTVAMLMRNT 316
A+TPVPGG GPMT+A LM+NT
Sbjct: 266 AITPVPGGVGPMTIAYLMKNT 286
>UniRef50_Q7TU81 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Prochlorococcus marinus|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Prochlorococcus marinus subsp. pastoris
(strain CCMP 1378 / MED4)
Length = 298
Score = 73.3 bits (172), Expect = 9e-13
Identities = 34/74 (45%), Positives = 52/74 (70%)
Frame = +3
Query: 21 HATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKS 200
+ATVT+ HSKT NL++I K A+IL+ A G+P ++ S++K GAV+ID GI+ + + KS
Sbjct: 182 NATVTITHSKTINLNKICKEADILIAAAGKPNLINSSFVKEGAVIIDVGIHRLTS-SDKS 240
Query: 201 GQRLVGDVAYQEAV 242
RL GDV ++ +
Sbjct: 241 KTRLCGDVLLEDVI 254
Score = 39.9 bits (89), Expect = 0.011
Identities = 17/22 (77%), Positives = 18/22 (81%)
Frame = +2
Query: 251 FAVTPVPGGXGPMTVAMLMRNT 316
FA TPVPGG GPMTV ML+ NT
Sbjct: 258 FAYTPVPGGVGPMTVTMLLVNT 279
>UniRef50_Q2B9L0 Cluster: Bifunctional protein FolD; n=1; Bacillus
sp. NRRL B-14911|Rep: Bifunctional protein FolD -
Bacillus sp. NRRL B-14911
Length = 322
Score = 72.1 bits (169), Expect = 2e-12
Identities = 29/56 (51%), Positives = 41/56 (73%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGIN 173
LL +ATVT CHS T+NLS A++++ A+G+PE ++G WIKPGAV++D G N
Sbjct: 217 LLLNRNATVTTCHSYTENLSRYVGQADLVIAAVGKPEFIKGEWIKPGAVILDAGYN 272
Score = 37.9 bits (84), Expect = 0.043
Identities = 13/25 (52%), Positives = 22/25 (88%)
Frame = +2
Query: 242 QSSFAVTPVPGGXGPMTVAMLMRNT 316
+ + A+TPVPGG GP+T++ML+++T
Sbjct: 286 EKASAITPVPGGVGPVTISMLLKHT 310
>UniRef50_Q8EV80 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma penetrans|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma penetrans
Length = 282
Score = 72.1 bits (169), Expect = 2e-12
Identities = 38/77 (49%), Positives = 53/77 (68%), Gaps = 2/77 (2%)
Frame = +3
Query: 21 HATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKS 200
+ATVTVCH+KT+NL E+TKTA+I+VVAIG+P+ + + P A VID GI+ ++
Sbjct: 180 NATVTVCHTKTQNLKEMTKTADIVVVAIGKPDFLTKDMVNPNAFVIDAGISVVDG----- 234
Query: 201 GQRLVGDVA--YQEAVK 245
++VGD A QE VK
Sbjct: 235 --KVVGDAAKDLQEYVK 249
Score = 30.3 bits (65), Expect = 8.6
Identities = 11/19 (57%), Positives = 15/19 (78%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRN 313
+TPVP G G +TVAM+ +N
Sbjct: 251 ITPVPNGVGRLTVAMIFKN 269
>UniRef50_Q9HPY4 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Halobacterium salinarium (Halobacterium
halobium)
Length = 297
Score = 72.1 bits (169), Expect = 2e-12
Identities = 36/78 (46%), Positives = 50/78 (64%)
Frame = +3
Query: 21 HATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKS 200
+ATVT+CHS T +L+ T+ A+++V A G PE++ G + VVID GIN ++ T+K
Sbjct: 185 NATVTICHSHTDDLAAHTRRADVVVAACGVPELIDGDMLSGDPVVIDVGINRVDADTEK- 243
Query: 201 GQRLVGDVAYQEAVKVAS 254
G LVGDV Y A AS
Sbjct: 244 GYELVGDVDYDSAEAAAS 261
Score = 38.3 bits (85), Expect = 0.033
Identities = 16/21 (76%), Positives = 18/21 (85%)
Frame = +2
Query: 254 AVTPVPGGXGPMTVAMLMRNT 316
A+TPVPGG GPMT AML+ NT
Sbjct: 262 AITPVPGGVGPMTRAMLLYNT 282
>UniRef50_Q24UZ7 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Peptococcaceae|Rep: Bifunctional protein folD 2
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Desulfitobacterium hafniense (strain Y51)
Length = 284
Score = 72.1 bits (169), Expect = 2e-12
Identities = 35/84 (41%), Positives = 55/84 (65%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
L+ +ATVT+CHS+T +L T+ A+I+V A+G+ ++V+ +KPGA+V+D GIN I
Sbjct: 176 LILKHNATVTICHSRTPDLGAFTRQADIIVAAVGKAKLVKKDMVKPGAIVVDAGINEIPG 235
Query: 186 PTKKSGQRLVGDVAYQEAVKVASL 257
+ GDV ++E +VASL
Sbjct: 236 -------GICGDVDFEEVKEVASL 252
Score = 30.7 bits (66), Expect = 6.5
Identities = 10/19 (52%), Positives = 16/19 (84%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRN 313
++PVPGG G +T A++M+N
Sbjct: 253 ISPVPGGVGSLTTALIMKN 271
>UniRef50_Q1II76 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Acidobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Acidobacteria bacterium (strain Ellin345)
Length = 307
Score = 71.7 bits (168), Expect = 3e-12
Identities = 33/60 (55%), Positives = 43/60 (71%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
LL +ATVT+CHSKT +L + + A+ILV AIGRP M+ ++KPGA V+D GIN I D
Sbjct: 177 LLTNANATVTICHSKTHDLPAVCRRADILVAAIGRPGMITPDFVKPGATVLDVGINKITD 236
Score = 39.5 bits (88), Expect = 0.014
Identities = 16/21 (76%), Positives = 18/21 (85%)
Frame = +2
Query: 254 AVTPVPGGXGPMTVAMLMRNT 316
A TPVPGG GP+T+AMLM NT
Sbjct: 275 AFTPVPGGVGPLTIAMLMANT 295
>UniRef50_Q9X288 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Thermotogaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermotoga maritima
Length = 271
Score = 71.3 bits (167), Expect = 4e-12
Identities = 32/59 (54%), Positives = 44/59 (74%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIE 182
L K ATVTVCHS+T NL EITK ++I+VVA+GR ++ + +K GA+VID GIN ++
Sbjct: 168 LKKGRDATVTVCHSRTVNLEEITKNSDIVVVAVGRAHFLKKNMVKEGAIVIDVGINYVD 226
>UniRef50_O83714 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Treponema pallidum
Length = 315
Score = 70.9 bits (166), Expect = 5e-12
Identities = 32/69 (46%), Positives = 47/69 (68%)
Frame = +3
Query: 24 ATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKSG 203
ATVT+CHS T+ L++I A+ILV A+G+ + +++ GAVVID GI+ + D T G
Sbjct: 186 ATVTLCHSHTRGLADICVQADILVAALGKARFIGAPFVRTGAVVIDVGIHHVPDATAPRG 245
Query: 204 QRLVGDVAY 230
+RL GDV +
Sbjct: 246 RRLCGDVDF 254
Score = 41.5 bits (93), Expect = 0.003
Identities = 16/21 (76%), Positives = 19/21 (90%)
Frame = +2
Query: 254 AVTPVPGGXGPMTVAMLMRNT 316
A+TPVPGG GPMT+AML+ NT
Sbjct: 263 AITPVPGGVGPMTIAMLLHNT 283
>UniRef50_Q6D2E6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Erwinia carotovora subsp. atroseptica (Pectobacterium
atrosepticum)
Length = 287
Score = 70.9 bits (166), Expect = 5e-12
Identities = 36/76 (47%), Positives = 51/76 (67%)
Frame = +3
Query: 27 TVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKSGQ 206
T TV H TKNL + A++LVVA+G+P + G WIKPGA+V+D GIN +E SG
Sbjct: 185 TTTVTHRFTKNLRHHIENADLLVVAVGKPGFIPGEWIKPGAIVLDVGINRLE-----SG- 238
Query: 207 RLVGDVAYQEAVKVAS 254
++VGD+ ++ A + AS
Sbjct: 239 KVVGDIEFETAQERAS 254
Score = 36.3 bits (80), Expect = 0.13
Identities = 14/20 (70%), Positives = 18/20 (90%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRNT 316
++PVPGG GPMTVA L++NT
Sbjct: 256 ISPVPGGVGPMTVATLIQNT 275
>UniRef50_Q987T6 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Alphaproteobacteria|Rep: Bifunctional protein folD
2 [Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rhizobium loti (Mesorhizobium loti)
Length = 306
Score = 70.1 bits (164), Expect = 9e-12
Identities = 37/83 (44%), Positives = 51/83 (61%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
LL E ATVTVCH T++++ + A+ L VA+G+P +++ +KPGA VID GIN+
Sbjct: 181 LLMSEGATVTVCHHLTRSVAAHARRADALFVAVGKPRLIKADMVKPGAAVIDIGINSEIG 240
Query: 186 PTKKSGQRLVGDVAYQEAVKVAS 254
P S R+VGDV VAS
Sbjct: 241 PDGTS--RIVGDVDTDSVKDVAS 261
Score = 39.1 bits (87), Expect = 0.019
Identities = 15/20 (75%), Positives = 19/20 (95%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRNT 316
+TPVPGG GP+TVA+L+RNT
Sbjct: 263 ITPVPGGVGPITVAILLRNT 282
>UniRef50_Q4FTX6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=24; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Psychrobacter arcticum
Length = 295
Score = 69.3 bits (162), Expect = 2e-11
Identities = 35/78 (44%), Positives = 50/78 (64%)
Frame = +3
Query: 21 HATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKS 200
+ TVT+CHS+T++L K A+I+V A+G PE+++ +WIK GAVVID G + PT
Sbjct: 194 NCTVTICHSRTQDLESHIKRADIVVGAVGVPELIKANWIKAGAVVIDAGFH----PTDNG 249
Query: 201 GQRLVGDVAYQEAVKVAS 254
G VGD+ Q +AS
Sbjct: 250 G---VGDIELQGVENIAS 264
Score = 34.3 bits (75), Expect = 0.53
Identities = 14/21 (66%), Positives = 16/21 (76%)
Frame = +2
Query: 254 AVTPVPGGXGPMTVAMLMRNT 316
A TPVPGG GPMT+ L+R T
Sbjct: 265 AYTPVPGGVGPMTINTLIRQT 285
>UniRef50_Q8RAD0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Thermoanaerobacter|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermoanaerobacter tengcongensis
Length = 280
Score = 68.9 bits (161), Expect = 2e-11
Identities = 33/60 (55%), Positives = 44/60 (73%)
Frame = +3
Query: 3 ELLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIE 182
+LL ++ TVTVCHSKTK+L+ TK A++LVVA G+ +VRG +K G V+ID GIN E
Sbjct: 172 KLLLDKNCTVTVCHSKTKDLAYHTKQADVLVVAAGKMNLVRGDMVKEGVVLIDAGINVHE 231
Score = 37.5 bits (83), Expect = 0.057
Identities = 14/20 (70%), Positives = 18/20 (90%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRNT 316
VTPVPGG GP+T AM+++NT
Sbjct: 250 VTPVPGGVGPVTTAMILKNT 269
>UniRef50_P56467 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Helicobacter pylori (Campylobacter pylori)
Length = 290
Score = 68.5 bits (160), Expect = 3e-11
Identities = 33/76 (43%), Positives = 51/76 (67%)
Frame = +3
Query: 24 ATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKSG 203
A+V+VCH TK++S T+ A+I+ V +G+P++++ S +K GAVV+D GIN + D
Sbjct: 187 ASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLND------ 240
Query: 204 QRLVGDVAYQEAVKVA 251
R+VGDV + KVA
Sbjct: 241 GRIVGDVDFNNVQKVA 256
Score = 32.7 bits (71), Expect = 1.6
Identities = 12/20 (60%), Positives = 15/20 (75%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRNT 316
+TPVP G GPMT+ L+ NT
Sbjct: 259 ITPVPKGVGPMTIVSLLENT 278
>UniRef50_Q97HC9 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; Clostridium|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Clostridium acetobutylicum
Length = 278
Score = 68.5 bits (160), Expect = 3e-11
Identities = 34/84 (40%), Positives = 53/84 (63%)
Frame = +3
Query: 3 ELLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIE 182
+LL E+ATVT+CHS+T+NL +I K A+I+V AIGRP + ++ ++VID G ++
Sbjct: 176 QLLLNENATVTICHSRTQNLKDICKKADIIVSAIGRPGFITDEFVNEKSIVIDVGTTVVD 235
Query: 183 DPTKKSGQRLVGDVAYQEAVKVAS 254
+L GDV + E +K A+
Sbjct: 236 G-------KLRGDVVFDEVIKKAA 252
Score = 34.7 bits (76), Expect = 0.40
Identities = 14/21 (66%), Positives = 15/21 (71%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRNTC 319
VTPVPGG G MT ML+ N C
Sbjct: 254 VTPVPGGVGAMTTTMLILNVC 274
>UniRef50_A4M873 Cluster: Tetrahydrofolate
dehydrogenase/cyclohydrolase; n=1; Petrotoga mobilis
SJ95|Rep: Tetrahydrofolate dehydrogenase/cyclohydrolase
- Petrotoga mobilis SJ95
Length = 273
Score = 68.1 bits (159), Expect = 4e-11
Identities = 31/53 (58%), Positives = 40/53 (75%)
Frame = +3
Query: 24 ATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIE 182
ATVTV H+KTKNL EITK A+ILV AIG+ V +++K G +VID GIN ++
Sbjct: 172 ATVTVTHTKTKNLKEITKEADILVAAIGKANFVDSTFVKEGMIVIDVGINVVD 224
Score = 32.7 bits (71), Expect = 1.6
Identities = 13/19 (68%), Positives = 16/19 (84%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRN 313
+TPVPGG G +T A+LMRN
Sbjct: 241 LTPVPGGVGSVTTAILMRN 259
>UniRef50_Q9ZD32 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Rickettsia|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rickettsia prowazekii
Length = 286
Score = 67.7 bits (158), Expect = 5e-11
Identities = 36/76 (47%), Positives = 48/76 (63%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
LL E+ +VT+CHSKT NLS IT A+I+VVAIG P + + P A+VID GIN I
Sbjct: 179 LLLQENCSVTICHSKTCNLSSITSKADIVVVAIGSPLKLTAEYFNPEAIVIDVGINRI-- 236
Query: 186 PTKKSGQRLVGDVAYQ 233
S ++ GDV ++
Sbjct: 237 ----SHNKIAGDVDFE 248
Score = 38.7 bits (86), Expect = 0.025
Identities = 14/20 (70%), Positives = 18/20 (90%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRNT 316
+TPVPGG GPMT+A L++NT
Sbjct: 257 ITPVPGGIGPMTIAFLLKNT 276
>UniRef50_Q9KQQ6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=44; Gammaproteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Vibrio cholerae
Length = 286
Score = 67.3 bits (157), Expect = 6e-11
Identities = 36/76 (47%), Positives = 49/76 (64%)
Frame = +3
Query: 27 TVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKSGQ 206
T T CH T++L + A+ILVVA+G+P + G+WIK GAVV+D GIN ++ +G
Sbjct: 185 TTTTCHRFTQDLEGHIRQADILVVAVGKPNFIPGAWIKEGAVVVDVGINRLD-----TG- 238
Query: 207 RLVGDVAYQEAVKVAS 254
+LVGDV Y A AS
Sbjct: 239 KLVGDVEYDVARTRAS 254
Score = 37.9 bits (84), Expect = 0.043
Identities = 17/25 (68%), Positives = 21/25 (84%)
Frame = +2
Query: 242 QSSFAVTPVPGGXGPMTVAMLMRNT 316
++SF +TPVPGG GPMTVA L+ NT
Sbjct: 252 RASF-ITPVPGGVGPMTVASLIENT 275
>UniRef50_Q6ALZ5 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=27; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Desulfotalea psychrophila
Length = 296
Score = 66.5 bits (155), Expect = 1e-10
Identities = 33/75 (44%), Positives = 50/75 (66%)
Frame = +3
Query: 21 HATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKS 200
+ATVT+ H+ +++L+ + A+IL+VA G P +V+ WIKPGA VID G+N + ++
Sbjct: 189 NATVTIVHTGSRDLATHCRRADILIVAAGVPNLVKPEWIKPGATVIDVGVNRVGTNSETG 248
Query: 201 GQRLVGDVAYQEAVK 245
L GDV + EAVK
Sbjct: 249 KAILRGDVDF-EAVK 262
Score = 41.9 bits (94), Expect = 0.003
Identities = 16/20 (80%), Positives = 19/20 (95%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRNT 316
+TPVPGG GPMT+AMLM+NT
Sbjct: 268 ITPVPGGVGPMTIAMLMKNT 287
>UniRef50_Q16F77 Cluster: Methylenetetrahydrofolate dehydrogenase;
n=4; cellular organisms|Rep: Methylenetetrahydrofolate
dehydrogenase - Aedes aegypti (Yellowfever mosquito)
Length = 337
Score = 65.7 bits (153), Expect = 2e-10
Identities = 33/78 (42%), Positives = 49/78 (62%), Gaps = 2/78 (2%)
Frame = +3
Query: 24 ATVTVCHSKT--KNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKK 197
ATVT+CH T + L+ +TA+I+V A G P +++ +K GA +ID GI ++DP +
Sbjct: 223 ATVTMCHRFTPPEELARFCRTADIIVTATGVPGLIKADMVKEGAAIIDVGITRVKDP-ET 281
Query: 198 SGQRLVGDVAYQEAVKVA 251
+LVGDV + E KVA
Sbjct: 282 GKNKLVGDVDFDEVRKVA 299
Score = 42.3 bits (95), Expect = 0.002
Identities = 17/20 (85%), Positives = 19/20 (95%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRNT 316
+TPVPGG GPMTVAMLM+NT
Sbjct: 302 ITPVPGGVGPMTVAMLMKNT 321
>UniRef50_Q14NV1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Spiroplasma citri|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Spiroplasma citri
Length = 286
Score = 65.7 bits (153), Expect = 2e-10
Identities = 30/54 (55%), Positives = 38/54 (70%)
Frame = +3
Query: 24 ATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
ATVTVCHS+TKNLS+ T A+IL+ A+G+ + V IK +VID GIN ED
Sbjct: 185 ATVTVCHSQTKNLSDFTNQADILISAVGKAKFVTAEMIKENVIVIDVGINRDED 238
Score = 35.5 bits (78), Expect = 0.23
Identities = 13/19 (68%), Positives = 16/19 (84%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRN 313
+TPVPGG GPMT+A L+ N
Sbjct: 257 ITPVPGGVGPMTIAALLEN 275
>UniRef50_Q057D7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Enterobacteriaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Buchnera aphidicola subsp. Cinara cedri
Length = 284
Score = 64.9 bits (151), Expect = 3e-10
Identities = 30/69 (43%), Positives = 47/69 (68%)
Frame = +3
Query: 27 TVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKSGQ 206
TVT+ + TKN+ K A+++V+AIG+P + G WIK GA+VID GIN + + K+
Sbjct: 185 TVTIVNKNTKNIKTYVKKADLVVIAIGQPNFLYGHWIKLGAIVIDIGINYLYN---KNKY 241
Query: 207 RLVGDVAYQ 233
++VGDV ++
Sbjct: 242 KIVGDVHFK 250
Score = 36.3 bits (80), Expect = 0.13
Identities = 14/20 (70%), Positives = 16/20 (80%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRNT 316
+TPVPGG GPMTV L+ NT
Sbjct: 259 ITPVPGGVGPMTVVSLLENT 278
>UniRef50_Q3AYX2 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=36; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Synechococcus sp. (strain CC9902)
Length = 293
Score = 64.5 bits (150), Expect = 4e-10
Identities = 38/83 (45%), Positives = 51/83 (61%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
+L+ +ATVTV HS+TK+L T+ A+I+VVA GRP MV IKPGA V+D GI+
Sbjct: 177 MLQAANATVTVVHSRTKDLVAHTREADIVVVAAGRPGMVGAEHIKPGAAVVDVGIH---- 232
Query: 186 PTKKSGQRLVGDVAYQEAVKVAS 254
+K L GDV E +A+
Sbjct: 233 --RKPEGGLCGDVRAAEVEPIAA 253
Score = 36.7 bits (81), Expect = 0.100
Identities = 15/21 (71%), Positives = 18/21 (85%)
Frame = +2
Query: 254 AVTPVPGGXGPMTVAMLMRNT 316
A++PVPGG GPMTV ML+ NT
Sbjct: 254 ALSPVPGGVGPMTVTMLLVNT 274
>UniRef50_A3PVV6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; Actinobacteridae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycobacterium sp. (strain JLS)
Length = 288
Score = 64.5 bits (150), Expect = 4e-10
Identities = 31/70 (44%), Positives = 46/70 (65%)
Frame = +3
Query: 18 EHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKK 197
E+ATVT+CH+ T++L + T+ A+I+V A G P MV ++PGA VID G+ ++
Sbjct: 186 ENATVTLCHTATRHLPQFTREADIIVAAAGVPHMVTAEMVRPGAAVIDVGV------SRD 239
Query: 198 SGQRLVGDVA 227
+LVGDVA
Sbjct: 240 DNGKLVGDVA 249
>UniRef50_A6LP88 Cluster: Tetrahydrofolate
dehydrogenase/cyclohydrolase; n=1; Thermosipho
melanesiensis BI429|Rep: Tetrahydrofolate
dehydrogenase/cyclohydrolase - Thermosipho melanesiensis
BI429
Length = 271
Score = 63.7 bits (148), Expect = 8e-10
Identities = 26/54 (48%), Positives = 40/54 (74%)
Frame = +3
Query: 24 ATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
ATVTVCH+KT+NLS ITK A+++V A GRP ++ ++ +++ID GIN ++
Sbjct: 174 ATVTVCHTKTRNLSSITKGADVVVAAAGRPGLITVDMVEKDSIIIDVGINVTDE 227
>UniRef50_Q5FJG5 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Firmicutes|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Lactobacillus acidophilus
Length = 283
Score = 63.7 bits (148), Expect = 8e-10
Identities = 33/83 (39%), Positives = 53/83 (63%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
L+ ++ATVT+ HS+T+NL+E+T+ A+I+V A G+ +V +K G VV+D G+N +
Sbjct: 176 LMLEQNATVTIAHSETENLAELTRNADIIVSATGQAFLVTEDMVKDGVVVVDVGMNHVNG 235
Query: 186 PTKKSGQRLVGDVAYQEAVKVAS 254
+LVGDV ++ K AS
Sbjct: 236 -------KLVGDVDFENVKKKAS 251
Score = 31.9 bits (69), Expect = 2.8
Identities = 12/17 (70%), Positives = 14/17 (82%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLM 307
+TPVPGG GP+TV LM
Sbjct: 253 ITPVPGGVGPLTVQFLM 269
>UniRef50_Q6MI74 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Bdellovibrio bacteriovorus|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Bdellovibrio
bacteriovorus
Length = 288
Score = 63.7 bits (148), Expect = 8e-10
Identities = 33/77 (42%), Positives = 49/77 (63%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
LL +ATVT+CHSKT N+SE+TK A+++VVA G+ ++ K A+VID G++
Sbjct: 177 LLTEANATVTLCHSKTSNMSELTKQADLVVVAAGKARLLGKEDFKKDAIVIDVGMHG--- 233
Query: 186 PTKKSGQRLVGDVAYQE 236
G +L GDV ++E
Sbjct: 234 --SGQGGKLCGDVRFEE 248
Score = 44.8 bits (101), Expect = 4e-04
Identities = 17/22 (77%), Positives = 20/22 (90%)
Frame = +2
Query: 254 AVTPVPGGXGPMTVAMLMRNTC 319
A TPVPGG GPMT+AML++NTC
Sbjct: 255 AATPVPGGVGPMTIAMLLKNTC 276
>UniRef50_Q74J95 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Lactobacillus|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Lactobacillus johnsonii
Length = 283
Score = 63.7 bits (148), Expect = 8e-10
Identities = 36/82 (43%), Positives = 50/82 (60%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
LL E+ATVT+ T N+ TK A+ILVVA G+P +++ +KPGA VID GIN
Sbjct: 178 LLINENATVTMVSLHTDNIDYYTKHADILVVAAGKPNLIKKDQVKPGATVIDVGIN---- 233
Query: 186 PTKKSGQRLVGDVAYQEAVKVA 251
+ + LVGDV + + +VA
Sbjct: 234 --RMANHYLVGDVDFDDVKEVA 253
Score = 36.7 bits (81), Expect = 0.100
Identities = 14/20 (70%), Positives = 17/20 (85%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRNT 316
+TPVPGG GPMT+A LM+ T
Sbjct: 256 ITPVPGGVGPMTIATLMQQT 275
>UniRef50_Q8RDM4 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Fusobacterium nucleatum|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Fusobacterium nucleatum subsp. nucleatum
Length = 283
Score = 63.3 bits (147), Expect = 1e-09
Identities = 33/76 (43%), Positives = 48/76 (63%)
Frame = +3
Query: 27 TVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKSGQ 206
TVT+C+ TKNL+E TK A+IL+ A+G+ +++ +K GAVVID GIN +
Sbjct: 183 TVTICNIYTKNLAEKTKNADILISAVGKAKLITEDMVKEGAVVIDVGINRVNG------- 235
Query: 207 RLVGDVAYQEAVKVAS 254
+L GDV ++ K AS
Sbjct: 236 KLEGDVDFENVQKKAS 251
Score = 33.5 bits (73), Expect = 0.93
Identities = 13/19 (68%), Positives = 16/19 (84%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRN 313
+TPVPGG G +TVAML+ N
Sbjct: 253 ITPVPGGVGALTVAMLLSN 271
>UniRef50_UPI000065DF90 Cluster: methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 2-like; n=1; Takifugu
rubripes|Rep: methylenetetrahydrofolate dehydrogenase
(NADP+ dependent) 2-like - Takifugu rubripes
Length = 400
Score = 62.9 bits (146), Expect = 1e-09
Identities = 34/71 (47%), Positives = 44/71 (61%), Gaps = 2/71 (2%)
Frame = +3
Query: 24 ATVTVCHSKTKN--LSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKK 197
ATVT+ H T L E+T+ A+I+V A G P ++ +K GA VID GIN I+DP K
Sbjct: 296 ATVTIAHRCTPKAQLKELTRLADIIVAAAGVPGLITADMVKEGAAVIDVGINRIQDP-KT 354
Query: 198 SGQRLVGDVAY 230
RLVGDV +
Sbjct: 355 GKVRLVGDVDF 365
Score = 41.1 bits (92), Expect = 0.005
Identities = 16/20 (80%), Positives = 19/20 (95%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRNT 316
+TPVPGG GPMTV+MLM+NT
Sbjct: 375 ITPVPGGVGPMTVSMLMKNT 394
>UniRef50_UPI00006CCCC6 Cluster: methylenetetrahydrofolate
dehydrogenase; n=1; Tetrahymena thermophila SB210|Rep:
methylenetetrahydrofolate dehydrogenase - Tetrahymena
thermophila SB210
Length = 342
Score = 62.5 bits (145), Expect = 2e-09
Identities = 34/87 (39%), Positives = 53/87 (60%), Gaps = 3/87 (3%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGIN-AIE 182
L K A +T C +T ++ + A++++ A G ++++G WIK GA+V+D G+N I
Sbjct: 192 LSKLSPAQITTCVKETGDIKQHILKADVIIAAAGERQLIKGKWIKKGAIVLDVGVNKGIP 251
Query: 183 --DPTKKSGQRLVGDVAYQEAVKVASL 257
DPTK +VGDV ++EA K ASL
Sbjct: 252 GIDPTK-----VVGDVEFEEAKKRASL 273
Score = 39.5 bits (88), Expect = 0.014
Identities = 16/20 (80%), Positives = 18/20 (90%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRNT 316
+TPVPGG GPMTV+MLM NT
Sbjct: 274 ITPVPGGIGPMTVSMLMYNT 293
>UniRef50_Q63SL6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=226; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Burkholderia pseudomallei (Pseudomonas
pseudomallei)
Length = 285
Score = 62.1 bits (144), Expect = 2e-09
Identities = 31/76 (40%), Positives = 47/76 (61%)
Frame = +3
Query: 24 ATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKSG 203
ATVT+CHSKT+ L+ T+ A+I+V A+G+ ++ +KPGA VID G+N +
Sbjct: 183 ATVTICHSKTRELAAHTRAADIVVAAVGKRNVLTADMVKPGATVIDVGMN------RNDE 236
Query: 204 QRLVGDVAYQEAVKVA 251
+L GDV + +VA
Sbjct: 237 GKLCGDVDFAGVSQVA 252
Score = 38.3 bits (85), Expect = 0.033
Identities = 18/45 (40%), Positives = 23/45 (51%)
Frame = +2
Query: 182 GSYKEKRATFSGRRGIPGGGQSSFAVTPVPGGXGPMTVAMLMRNT 316
G + G G Q + +TPVPGG GPMT+ ML+ NT
Sbjct: 230 GMNRNDEGKLCGDVDFAGVSQVAGHITPVPGGVGPMTITMLLVNT 274
>UniRef50_Q6L046 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermoplasmatales|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Picrophilus torridus
Length = 276
Score = 61.7 bits (143), Expect = 3e-09
Identities = 25/55 (45%), Positives = 41/55 (74%)
Frame = +3
Query: 27 TVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPT 191
TVTVCHS+T N++EIT++++I+VVA+G+P + S++ ++ID GIN + T
Sbjct: 177 TVTVCHSRTVNINEITRSSDIVVVAVGKPNFLDRSYVSDKNIIIDVGINYLNGKT 231
Score = 30.3 bits (65), Expect = 8.6
Identities = 11/20 (55%), Positives = 14/20 (70%)
Frame = +2
Query: 254 AVTPVPGGXGPMTVAMLMRN 313
A+TPVPGG GP+T + N
Sbjct: 246 AITPVPGGVGPVTATDIFEN 265
>UniRef50_A0C3Q0 Cluster: Chromosome undetermined scaffold_147,
whole genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_147,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 404
Score = 60.9 bits (141), Expect = 5e-09
Identities = 37/84 (44%), Positives = 52/84 (61%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
LL+ +ATVTVCH +T NL + A+I++ A G P++VR +K GA+VID GI+ E
Sbjct: 283 LLQKRNATVTVCHRETLNLDQHIMNADIVISAAGHPKLVRN--VKQGAIVIDVGISQGE- 339
Query: 186 PTKKSGQRLVGDVAYQEAVKVASL 257
K G ++VGDV + ASL
Sbjct: 340 ---KKG-KIVGDVDFDVVKNQASL 359
Score = 43.2 bits (97), Expect = 0.001
Identities = 17/21 (80%), Positives = 18/21 (85%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRNTC 319
+TPVPGG GPMTV MLMRN C
Sbjct: 360 ITPVPGGVGPMTVCMLMRNLC 380
>UniRef50_Q2JCX4 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Frankia|Rep: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Frankia sp. (strain CcI3)
Length = 276
Score = 60.9 bits (141), Expect = 5e-09
Identities = 28/54 (51%), Positives = 36/54 (66%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCG 167
LL E ATVT+CHS+TK L I A+I+V A G P +V +++PGA VID G
Sbjct: 173 LLLAEDATVTICHSRTKGLVSIAHEADIIVSATGHPRLVGAGFVRPGAAVIDVG 226
Score = 36.7 bits (81), Expect = 0.100
Identities = 14/21 (66%), Positives = 18/21 (85%)
Frame = +2
Query: 254 AVTPVPGGXGPMTVAMLMRNT 316
A+TPVPGG GP+T +L+RNT
Sbjct: 249 ALTPVPGGVGPVTTMLLLRNT 269
>UniRef50_UPI00015B49ED Cluster: PREDICTED: similar to putative
glyoxylate reductase/hydroxypyruvate reductase; n=1;
Nasonia vitripennis|Rep: PREDICTED: similar to putative
glyoxylate reductase/hydroxypyruvate reductase - Nasonia
vitripennis
Length = 699
Score = 60.1 bits (139), Expect = 9e-09
Identities = 35/77 (45%), Positives = 44/77 (57%), Gaps = 2/77 (2%)
Frame = +3
Query: 27 TVTVCHSKTKN--LSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKS 200
T T+CH T L TK A+I+V + G P +V IKPGA VID GI+ I+ T +
Sbjct: 218 TTTICHRYTPRVELERYTKLADIVVASAGVPGLVTKEMIKPGACVIDVGISRIK--TSEG 275
Query: 201 GQRLVGDVAYQEAVKVA 251
RLVGDV Y+ VA
Sbjct: 276 KYRLVGDVNYESVKTVA 292
Score = 42.3 bits (95), Expect = 0.002
Identities = 17/20 (85%), Positives = 19/20 (95%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRNT 316
+TPVPGG GPMTVAMLM+NT
Sbjct: 295 ITPVPGGVGPMTVAMLMKNT 314
>UniRef50_A0DMT9 Cluster: Chromosome undetermined scaffold_57, whole
genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_57,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 309
Score = 59.7 bits (138), Expect = 1e-08
Identities = 32/79 (40%), Positives = 48/79 (60%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
LL +A VT+CHS+T + E + A+I++ G E+V+G WIK GA VID GI I
Sbjct: 183 LLLKRNARVTICHSET-TVQEHVEKADIVISCAGHKELVKGEWIKNGAKVIDVGITRI-- 239
Query: 186 PTKKSGQRLVGDVAYQEAV 242
++VGD+ +Q+A+
Sbjct: 240 ---PGTNQIVGDIEFQKAL 255
Score = 37.1 bits (82), Expect = 0.075
Identities = 14/19 (73%), Positives = 17/19 (89%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRN 313
+TPVPGG GP+TV+ML RN
Sbjct: 261 ITPVPGGVGPLTVSMLFRN 279
>UniRef50_Q83FS2 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Tropheryma whipplei|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Tropheryma whipplei (strain Twist)
(Whipple's bacillus)
Length = 295
Score = 59.7 bits (138), Expect = 1e-08
Identities = 31/72 (43%), Positives = 46/72 (63%), Gaps = 1/72 (1%)
Frame = +3
Query: 12 KWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPT 191
K +ATV HS+++N+S +++ A+++V G +V SWIKPGAVV+D GIN +
Sbjct: 181 KGVNATVINIHSRSRNISGLSRIADVVVACAGVKHIVEPSWIKPGAVVVDVGIN--QSGV 238
Query: 192 KKSGQR-LVGDV 224
SG+ L GDV
Sbjct: 239 SSSGKMILTGDV 250
Score = 31.1 bits (67), Expect = 4.9
Identities = 13/19 (68%), Positives = 15/19 (78%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRN 313
++PV GG GPMT AMLM N
Sbjct: 261 ISPVVGGVGPMTRAMLMSN 279
>UniRef50_Q979W3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermoplasma|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermoplasma volcanium
Length = 281
Score = 59.7 bits (138), Expect = 1e-08
Identities = 24/53 (45%), Positives = 39/53 (73%)
Frame = +3
Query: 27 TVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
TV++CHSKT ++ I K ++I+VVA+GRP + +++ +VVID GIN ++D
Sbjct: 178 TVSICHSKTPDIRSIAKASKIIVVAVGRPGFLDDTYVTESSVVIDVGINYVQD 230
Score = 31.5 bits (68), Expect = 3.7
Identities = 12/20 (60%), Positives = 15/20 (75%)
Frame = +2
Query: 254 AVTPVPGGXGPMTVAMLMRN 313
AVTPVPGG GP+T ++ N
Sbjct: 247 AVTPVPGGVGPITATNILSN 266
>UniRef50_Q0AWX5 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Syntrophomonas wolfei subsp. wolfei str.
Goettingen|Rep: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Syntrophomonas wolfei subsp. wolfei (strain Goettingen)
Length = 272
Score = 58.4 bits (135), Expect = 3e-08
Identities = 28/56 (50%), Positives = 37/56 (66%)
Frame = +3
Query: 18 EHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
E+ATVTVCH++T+NL E A+ILV A+G+ E V + VVID GIN E+
Sbjct: 173 ENATVTVCHTRTRNLKEEALRADILVAAVGKREFVTADMVHKDMVVIDVGINFDEN 228
>UniRef50_Q0SFQ8 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Actinomycetales|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rhodococcus sp. (strain RHA1)
Length = 297
Score = 58.4 bits (135), Expect = 3e-08
Identities = 35/73 (47%), Positives = 45/73 (61%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
LL +ATVTVCH T +L+ T+ A+ILVVA+G P ++ + GAVVID G A D
Sbjct: 176 LLVQRNATVTVCHRHTTDLAAGTRDADILVVAVGIPGLITADHVADGAVVIDVGTTATAD 235
Query: 186 PTKKSGQRLVGDV 224
GQ L+GDV
Sbjct: 236 -----GQ-LLGDV 242
Score = 34.7 bits (76), Expect = 0.40
Identities = 13/21 (61%), Positives = 18/21 (85%)
Frame = +2
Query: 254 AVTPVPGGXGPMTVAMLMRNT 316
A+TPVPGG GP+T A+L+ +T
Sbjct: 253 ALTPVPGGVGPVTTALLLNHT 273
>UniRef50_Q54VK0 Cluster: Methenyl tetrahydrofolate cyclohydrolase /
NADP-dependent methylene H4F dehydrogenase; n=1;
Dictyostelium discoideum AX4|Rep: Methenyl
tetrahydrofolate cyclohydrolase / NADP-dependent
methylene H4F dehydrogenase - Dictyostelium discoideum
AX4
Length = 440
Score = 58.0 bits (134), Expect = 4e-08
Identities = 26/67 (38%), Positives = 43/67 (64%)
Frame = +3
Query: 24 ATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKSG 203
A VT+ H +KN + A++++ A G P +++ +K G ++ID GI+ ED TKKSG
Sbjct: 277 ANVTIIHKYSKNHLGSIRQADLIISATGVPGLIKKEDLKRGVILIDVGISFKEDSTKKSG 336
Query: 204 QRLVGDV 224
++VGD+
Sbjct: 337 YKMVGDI 343
Score = 40.3 bits (90), Expect = 0.008
Identities = 22/47 (46%), Positives = 27/47 (57%), Gaps = 4/47 (8%)
Frame = +2
Query: 185 SYKEKRATFSGRRGI----PGGGQSSFAVTPVPGGXGPMTVAMLMRN 313
S+KE SG + + P S A TPVPGG GP+TVA L+RN
Sbjct: 326 SFKEDSTKKSGYKMVGDIDPEAYSRSIAYTPVPGGVGPLTVACLLRN 372
>UniRef50_A7DNA7 Cluster: Methylenetetrahydrofolate dehydrogenase
(NADP(+)); n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Methylenetetrahydrofolate dehydrogenase
(NADP(+)) - Candidatus Nitrosopumilus maritimus SCM1
Length = 287
Score = 57.6 bits (133), Expect = 5e-08
Identities = 32/85 (37%), Positives = 52/85 (61%), Gaps = 2/85 (2%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIG--RPEMVRGSWIKPGAVVIDCGINAI 179
LL ++ATV CHS+TKNL E+ ++A+I++ A+G + IK GA+VID I+
Sbjct: 177 LLLDKNATVITCHSRTKNLVELCQSADIIITAVGDRNKFTLTSDMIKEGAIVIDVAISRF 236
Query: 180 EDPTKKSGQRLVGDVAYQEAVKVAS 254
+ ++LVGD Y++ ++ AS
Sbjct: 237 Q-------EKLVGDADYEDIIQKAS 254
Score = 41.9 bits (94), Expect = 0.003
Identities = 19/25 (76%), Positives = 23/25 (92%)
Frame = +2
Query: 242 QSSFAVTPVPGGXGPMTVAMLMRNT 316
++SFA TPVPGG GPMTVAML++NT
Sbjct: 252 KASFA-TPVPGGVGPMTVAMLLKNT 275
>UniRef50_O84081 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Chlamydiaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Chlamydia trachomatis
Length = 287
Score = 57.6 bits (133), Expect = 5e-08
Identities = 32/76 (42%), Positives = 47/76 (61%)
Frame = +3
Query: 21 HATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKS 200
+A+VT+ HS++++L+EIT+TA+IL+ AIG P V I V++D G + I K
Sbjct: 181 NASVTLLHSQSEHLTEITRTADILISAIGVPLFVNKEMIAEKTVIMDVGTSRIPAANPK- 239
Query: 201 GQRLVGDVAYQEAVKV 248
G LVGDV + V V
Sbjct: 240 GYILVGDVDFNNVVPV 255
Score = 45.2 bits (102), Expect = 3e-04
Identities = 19/21 (90%), Positives = 20/21 (95%)
Frame = +2
Query: 254 AVTPVPGGXGPMTVAMLMRNT 316
A+TPVPGG GPMTVAMLMRNT
Sbjct: 258 AITPVPGGVGPMTVAMLMRNT 278
>UniRef50_UPI0000DB7ABF Cluster: PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor; n=1; Apis mellifera|Rep:
PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor - Apis mellifera
Length = 407
Score = 56.8 bits (131), Expect = 9e-08
Identities = 30/77 (38%), Positives = 45/77 (58%), Gaps = 2/77 (2%)
Frame = +3
Query: 27 TVTVCHSKTKN--LSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKS 200
T T+CH T + L + TK A+++VVA G P ++ IKPGA +ID GI I+ K
Sbjct: 300 TTTICHRHTPHTELEKFTKLADLVVVAAGIPGLITKEMIKPGACIIDVGITRIKMDNK-- 357
Query: 201 GQRLVGDVAYQEAVKVA 251
++VGDV ++ +A
Sbjct: 358 -YKIVGDVDFENVKSIA 373
Score = 42.3 bits (95), Expect = 0.002
Identities = 17/20 (85%), Positives = 19/20 (95%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRNT 316
+TPVPGG GPMTVAMLM+NT
Sbjct: 376 ITPVPGGVGPMTVAMLMKNT 395
>UniRef50_Q8TK95 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Methanosarcina acetivorans
Length = 290
Score = 55.2 bits (127), Expect = 3e-07
Identities = 30/79 (37%), Positives = 45/79 (56%)
Frame = +3
Query: 21 HATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKS 200
+ATV+VCH T +L + T A+I+VVA G +++ +K G V+ D GI ED
Sbjct: 191 NATVSVCHIFTDDLKKYTLGADIIVVATGVKHLIKADMVKEGTVIFDAGITKEED----- 245
Query: 201 GQRLVGDVAYQEAVKVASL 257
+ GDV ++ +K ASL
Sbjct: 246 --GVYGDVDFENVIKKASL 262
Score = 38.3 bits (85), Expect = 0.033
Identities = 15/19 (78%), Positives = 18/19 (94%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRN 313
VTPVPGG GPMT+AMLM++
Sbjct: 263 VTPVPGGVGPMTIAMLMKH 281
>UniRef50_P13995 Cluster: Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor
[Includes: NAD-dependent methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)]; n=66; cellular
organisms|Rep: Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor
[Includes: NAD-dependent methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Homo sapiens (Human)
Length = 350
Score = 54.8 bits (126), Expect = 4e-07
Identities = 30/72 (41%), Positives = 43/72 (59%), Gaps = 2/72 (2%)
Frame = +3
Query: 24 ATVTVCHSKT--KNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKK 197
ATVT+ H T + L + T A+I++ A G P ++ IK GA VID GIN + DP
Sbjct: 226 ATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDPV-T 284
Query: 198 SGQRLVGDVAYQ 233
+ +LVGDV ++
Sbjct: 285 AKPKLVGDVDFE 296
Score = 43.2 bits (97), Expect = 0.001
Identities = 19/28 (67%), Positives = 22/28 (78%)
Frame = +2
Query: 233 GGGQSSFAVTPVPGGXGPMTVAMLMRNT 316
G Q + +TPVPGG GPMTVAMLM+NT
Sbjct: 297 GVRQKAGYITPVPGGVGPMTVAMLMKNT 324
>UniRef50_A0JTZ0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=51; Actinobacteria (class)|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Arthrobacter sp. (strain FB24)
Length = 302
Score = 54.8 bits (126), Expect = 4e-07
Identities = 27/69 (39%), Positives = 47/69 (68%), Gaps = 1/69 (1%)
Frame = +3
Query: 21 HATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDP-TKK 197
+ATVT+ H+ T+NLS++ + A+++V A G +V+ + +KPGA ++D G+ DP T K
Sbjct: 190 NATVTLTHTGTENLSQLLRQADVIVGAAGAKHIVKAADVKPGAALLDVGVTRETDPETGK 249
Query: 198 SGQRLVGDV 224
S ++ GD+
Sbjct: 250 S--KVHGDI 256
Score = 34.3 bits (75), Expect = 0.53
Identities = 14/28 (50%), Positives = 19/28 (67%)
Frame = +2
Query: 230 PGGGQSSFAVTPVPGGXGPMTVAMLMRN 313
P + + ++P PGG GPMTVA+LM N
Sbjct: 258 PAAAEVAGWISPNPGGVGPMTVALLMTN 285
>UniRef50_Q6F1V0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Mollicutes|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mesoplasma florum (Acholeplasma florum)
Length = 286
Score = 53.6 bits (123), Expect = 8e-07
Identities = 32/77 (41%), Positives = 46/77 (59%)
Frame = +3
Query: 24 ATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKSG 203
AT+T+C+ TKN+ T A+I++ A G+ ++ IK AV+ID GI I DP
Sbjct: 182 ATITMCNKNTKNIKNHTINADIIISATGKQFIITEDMIKKDAVIIDVGI--IRDPVT--- 236
Query: 204 QRLVGDVAYQEAVKVAS 254
+LVGDV + E VK+ S
Sbjct: 237 NKLVGDVDF-EKVKLKS 252
Score = 37.5 bits (83), Expect = 0.057
Identities = 17/25 (68%), Positives = 20/25 (80%)
Frame = +2
Query: 242 QSSFAVTPVPGGXGPMTVAMLMRNT 316
+SS+ +TPVPGG GPMTV LM NT
Sbjct: 251 KSSY-ITPVPGGVGPMTVITLMENT 274
>UniRef50_A4EAK0 Cluster: Putative uncharacterized protein; n=3;
Bacteria|Rep: Putative uncharacterized protein -
Collinsella aerofaciens ATCC 25986
Length = 284
Score = 53.2 bits (122), Expect = 1e-06
Identities = 28/78 (35%), Positives = 45/78 (57%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
+L +ATVT CH+ T++L+ + A+I+V A+GR + ++ G +ID GIN E
Sbjct: 177 MLTARNATVTTCHTHTRDLAAECRAADIVVAAVGRARTIGADAVRGGQTIIDVGINWDE- 235
Query: 186 PTKKSGQRLVGDVAYQEA 239
+ +LVGDV + A
Sbjct: 236 ----AAGKLVGDVDFDAA 249
>UniRef50_Q74GN1 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Bacteria|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Geobacter sulfurreducens
Length = 290
Score = 51.6 bits (118), Expect = 3e-06
Identities = 31/80 (38%), Positives = 48/80 (60%), Gaps = 2/80 (2%)
Frame = +3
Query: 21 HATVTVCHSKTKN--LSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTK 194
+ATVT+ H +T L + T+ A+I++VA+G P V +K G V+ID GIN +E
Sbjct: 185 NATVTLTHIETPRELLLDETRRADIVIVAVGIPGFVTADMVKDGVVLIDVGINRLE---- 240
Query: 195 KSGQRLVGDVAYQEAVKVAS 254
SG ++VGDV ++ + S
Sbjct: 241 -SG-KIVGDVDFENVAQKCS 258
Score = 34.3 bits (75), Expect = 0.53
Identities = 15/20 (75%), Positives = 16/20 (80%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRNT 316
+TPVPGG G MTVA LM NT
Sbjct: 260 ITPVPGGVGRMTVAALMINT 279
>UniRef50_Q6BNW9 Cluster: Debaryomyces hansenii chromosome E of
strain CBS767 of Debaryomyces hansenii; n=2;
Debaryomyces hansenii|Rep: Debaryomyces hansenii
chromosome E of strain CBS767 of Debaryomyces hansenii -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 276
Score = 50.0 bits (114), Expect = 1e-05
Identities = 19/45 (42%), Positives = 30/45 (66%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIK 140
+L+ E TVT+CH T +L + + A+I+V A+G PE V+ W+K
Sbjct: 222 MLRNEDCTVTICHRHTYDLPSVVRNADIIVAAVGIPEYVKADWVK 266
>UniRef50_Q3A1Q7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Pelobacter carbinolicus (strain DSM 2380 / Gra Bd 1)
Length = 290
Score = 49.6 bits (113), Expect = 1e-05
Identities = 28/71 (39%), Positives = 40/71 (56%)
Frame = +3
Query: 15 WEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTK 194
+ +A VTV HS K+L T+ A+I++ A G P +V+ I+PGAVVI GI+
Sbjct: 184 YANAAVTVVHSGIKDLGAYTRRADIVIAAAGCPGIVQPDMIRPGAVVISGGISWEGRKLL 243
Query: 195 KSGQRLVGDVA 227
VG+VA
Sbjct: 244 PDVDEAVGEVA 254
Score = 30.7 bits (66), Expect = 6.5
Identities = 14/26 (53%), Positives = 18/26 (69%)
Frame = +2
Query: 239 GQSSFAVTPVPGGXGPMTVAMLMRNT 316
G+ + +TP GG GP TVAML+ NT
Sbjct: 251 GEVAGWITPRLGGVGPTTVAMLLLNT 276
>UniRef50_Q9RW02 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Deinococcus|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Deinococcus radiodurans
Length = 299
Score = 48.4 bits (110), Expect = 3e-05
Identities = 22/59 (37%), Positives = 38/59 (64%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIE 182
+L + ATVT+C+ T++L+ + + +VVA+G+ ++R ++P VVID GIN E
Sbjct: 191 MLNNKGATVTLCNEHTRDLAAVLAAQDAVVVAVGKAGLLRPEQVQPEHVVIDAGINVQE 249
Score = 31.5 bits (68), Expect = 3.7
Identities = 12/20 (60%), Positives = 16/20 (80%)
Frame = +2
Query: 254 AVTPVPGGXGPMTVAMLMRN 313
A TPVPGG GP+T A++ +N
Sbjct: 265 AQTPVPGGVGPLTSALMYQN 284
>UniRef50_Q4DH06 Cluster: Methylenetetrahydrofolate
dehydrogenase-like protein, putative; n=1; Trypanosoma
cruzi|Rep: Methylenetetrahydrofolate dehydrogenase-like
protein, putative - Trypanosoma cruzi
Length = 375
Score = 48.0 bits (109), Expect = 4e-05
Identities = 28/79 (35%), Positives = 47/79 (59%), Gaps = 6/79 (7%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLS---EITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGIN- 173
L K ++ VT+C S++ +L E+++ A++LV A+G P +V ++KPGA+V+D IN
Sbjct: 214 LQKEDNFLVTLC-SRSNDLEAVKEVSRQADVLVTALGIPRVVTADFVKPGAIVLDVAINE 272
Query: 174 --AIEDPTKKSGQRLVGDV 224
A +R+ GDV
Sbjct: 273 DCASGGEMTSGSRRVCGDV 291
Score = 40.7 bits (91), Expect = 0.006
Identities = 17/25 (68%), Positives = 21/25 (84%)
Frame = +2
Query: 242 QSSFAVTPVPGGXGPMTVAMLMRNT 316
+ + AVTPVPGG GP+TVA LM+NT
Sbjct: 298 EKAAAVTPVPGGIGPLTVAYLMQNT 322
>UniRef50_A5CF58 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Orientia tsutsugamushi Boryong|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Orientia tsutsugamushi
(strain Boryong) (Rickettsia tsutsugamushi)
Length = 301
Score = 47.2 bits (107), Expect = 7e-05
Identities = 26/72 (36%), Positives = 40/72 (55%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
LL TVT+CHS T +L+ T+TA+I++ A+G+ + ID GI+ I D
Sbjct: 178 LLLRNSCTVTICHSATVDLALHTRTADIVISAVGKANFLTDKHFSGNLAFIDVGISHIYD 237
Query: 186 PTKKSGQRLVGD 221
+ ++LVGD
Sbjct: 238 -LQTHKRKLVGD 248
Score = 38.7 bits (86), Expect = 0.025
Identities = 15/20 (75%), Positives = 18/20 (90%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRNT 316
+TPVPGG GPMTVA L++NT
Sbjct: 261 ITPVPGGVGPMTVAYLLKNT 280
>UniRef50_A6NP56 Cluster: Uncharacterized protein ENSP00000372121;
n=5; Eutheria|Rep: Uncharacterized protein
ENSP00000372121 - Homo sapiens (Human)
Length = 200
Score = 46.8 bits (106), Expect = 9e-05
Identities = 27/72 (37%), Positives = 41/72 (56%), Gaps = 2/72 (2%)
Frame = +3
Query: 24 ATVTVCHSKT--KNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKK 197
ATVT+ + T + L + T A+I++ A G P ++ IK A V D GIN + DP
Sbjct: 101 ATVTISYRYTSKEQLKKHTILADIVISAAGIPNLITADMIKEEAAVTDMGINRVHDPV-T 159
Query: 198 SGQRLVGDVAYQ 233
+ +LVGDV ++
Sbjct: 160 AKLKLVGDVDFE 171
Score = 43.2 bits (97), Expect = 0.001
Identities = 19/28 (67%), Positives = 22/28 (78%)
Frame = +2
Query: 233 GGGQSSFAVTPVPGGXGPMTVAMLMRNT 316
G Q + +TPVPGG GPMTVAMLM+NT
Sbjct: 172 GVRQKAGYITPVPGGVGPMTVAMLMKNT 199
>UniRef50_O51057 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Borrelia burgdorferi group|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Borrelia burgdorferi
(Lyme disease spirochete)
Length = 308
Score = 46.4 bits (105), Expect = 1e-04
Identities = 26/69 (37%), Positives = 40/69 (57%)
Frame = +3
Query: 24 ATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKSG 203
ATV VCHSK+ L + A+I++ A+G+P ++ S + VID GI+ IE +G
Sbjct: 191 ATVIVCHSKSIYLDVYLRQADIVISAVGKPRLIDKSMLCGKPYVIDIGISEIE---TDNG 247
Query: 204 QRLVGDVAY 230
+ L GD +
Sbjct: 248 KILSGDTDF 256
Score = 33.5 bits (73), Expect = 0.93
Identities = 14/20 (70%), Positives = 16/20 (80%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRNT 316
+TPV GG GP+TV MLM NT
Sbjct: 266 ITPVKGGIGPVTVLMLMFNT 285
>UniRef50_UPI00005A5066 Cluster: PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor; n=1; Canis lupus
familiaris|Rep: PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor - Canis familiaris
Length = 239
Score = 46.0 bits (104), Expect = 2e-04
Identities = 25/71 (35%), Positives = 42/71 (59%)
Frame = +3
Query: 42 HSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKSGQRLVGD 221
++ + L + T AEI++ A+G ++ IK GA +I+ GIN ++DP S +LVGD
Sbjct: 102 YTPKEQLKKCTVLAEIVISAVGILNLITADIIKEGAALINVGINRVQDPI-LSKAKLVGD 160
Query: 222 VAYQEAVKVAS 254
V ++ K A+
Sbjct: 161 VDFEGIRKNAN 171
Score = 31.9 bits (69), Expect = 2.8
Identities = 15/20 (75%), Positives = 17/20 (85%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRNT 316
+TPV G GPMTVAMLM+NT
Sbjct: 173 ITPV-WGVGPMTVAMLMKNT 191
>UniRef50_Q6LEW8 Cluster: Putative uncharacterized protein; n=1;
Plasmodium falciparum 3D7|Rep: Putative uncharacterized
protein - Plasmodium falciparum (isolate 3D7)
Length = 657
Score = 44.8 bits (101), Expect = 4e-04
Identities = 20/53 (37%), Positives = 34/53 (64%), Gaps = 1/53 (1%)
Frame = +3
Query: 54 KNLS-EITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKSGQR 209
KN+ EI K+A+I+++ IGR ++ IK +++D GIN I P+KK ++
Sbjct: 426 KNMEKEIIKSADIIIIGIGRHHILSKRHIKENVIILDLGINLIPSPSKKKTKK 478
>UniRef50_Q1AVQ0 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Rubrobacter xylanophilus DSM 9941|Rep: Bifunctional
protein folD 2 [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Rubrobacter xylanophilus
(strain DSM 9941 / NBRC 16129)
Length = 320
Score = 44.0 bits (99), Expect = 7e-04
Identities = 21/64 (32%), Positives = 34/64 (53%)
Frame = +3
Query: 60 LSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKSGQRLVGDVAYQEA 239
L E T A+ L+VA G ++ S+++ G + +D GIN + DP LVGD+ +
Sbjct: 206 LREHTLKADALIVAAGVAGLIDESYVREGVIAVDVGINPVADPGGSGRTLLVGDLDFGSV 265
Query: 240 VKVA 251
+ A
Sbjct: 266 ARKA 269
Score = 33.5 bits (73), Expect = 0.93
Identities = 13/21 (61%), Positives = 17/21 (80%)
Frame = +2
Query: 254 AVTPVPGGXGPMTVAMLMRNT 316
A+TPVPGG GP+T L++NT
Sbjct: 271 ALTPVPGGVGPITDVWLLKNT 291
>UniRef50_UPI00006CB712 Cluster: tetrahydrofolate
dehydrogenase/cyclohydrolase, NAD(P)-binding domain;
n=1; Tetrahymena thermophila SB210|Rep: tetrahydrofolate
dehydrogenase/cyclohydrolase, NAD(P)-binding domain -
Tetrahymena thermophila SB210
Length = 377
Score = 43.2 bits (97), Expect = 0.001
Identities = 28/73 (38%), Positives = 42/73 (57%), Gaps = 1/73 (1%)
Frame = +3
Query: 24 ATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKSG 203
A V++C K+ +LS K A+ILV A G ++V+G +K G +VID G + P
Sbjct: 209 AIVSMCDKKS-DLSIALKDADILVSATGVRKLVKGEQLKKGVIVIDVGCSR---PLPHED 264
Query: 204 Q-RLVGDVAYQEA 239
Q +VGDV ++ A
Sbjct: 265 QSSIVGDVEFESA 277
Score = 36.3 bits (80), Expect = 0.13
Identities = 14/24 (58%), Positives = 21/24 (87%)
Frame = +2
Query: 242 QSSFAVTPVPGGXGPMTVAMLMRN 313
+S+ +TPVPGG GP+TV+ML++N
Sbjct: 275 ESASLLTPVPGGVGPVTVSMLIQN 298
>UniRef50_Q04FB7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Leuconostocaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Oenococcus oeni (strain BAA-331 / PSU-1)
Length = 285
Score = 41.5 bits (93), Expect = 0.003
Identities = 24/60 (40%), Positives = 34/60 (56%), Gaps = 2/60 (3%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTK--NLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAI 179
LL TVT+ HSKT L + K A+++VVAIG+ + + +K VVID G N +
Sbjct: 175 LLTNRDMTVTLAHSKTPVDQLRQFAKRADLIVVAIGKANWFQFTDLKKDVVVIDVGANKL 234
Score = 34.3 bits (75), Expect = 0.53
Identities = 12/20 (60%), Positives = 18/20 (90%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLMRNT 316
++PVPGG GPMT+A L+++T
Sbjct: 254 ISPVPGGVGPMTIATLIKHT 273
>UniRef50_Q7NAE4 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Mycoplasma gallisepticum|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Mycoplasma gallisepticum
Length = 283
Score = 41.5 bits (93), Expect = 0.003
Identities = 21/65 (32%), Positives = 37/65 (56%)
Frame = +3
Query: 60 LSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTKKSGQRLVGDVAYQEA 239
L E TK A++++ A+G+ + + K G + ID GI+ DP ++S + GD Y +
Sbjct: 188 LEEKTKVADLVISAVGKAKFLANYQFKRGVIFIDIGIDKYFDP-EQSKYLICGDFDYDKL 246
Query: 240 VKVAS 254
++AS
Sbjct: 247 KEIAS 251
>UniRef50_A5K2D8 Cluster: Putative uncharacterized protein; n=1;
Plasmodium vivax|Rep: Putative uncharacterized protein -
Plasmodium vivax
Length = 614
Score = 41.1 bits (92), Expect = 0.005
Identities = 17/43 (39%), Positives = 30/43 (69%), Gaps = 1/43 (2%)
Frame = +3
Query: 54 KNLSE-ITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAI 179
KN+ I K A+++++AIG P +++ IK GA+++D GIN +
Sbjct: 384 KNMGRRIVKQADVIIIAIGCPHLLKKRNIKEGAIILDLGINLV 426
>UniRef50_Q8ZZK1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Pyrobaculum|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Pyrobaculum aerophilum
Length = 311
Score = 39.1 bits (87), Expect = 0.019
Identities = 26/66 (39%), Positives = 36/66 (54%), Gaps = 8/66 (12%)
Frame = +3
Query: 24 ATVTVCHSKTKNLSEITKTAEILVVAIGR-PEMVR-------GSWIKPGAVVIDCGINAI 179
ATVTV H+ +K K A+I++ A+GR PE+ + G IK GAVV+ G+
Sbjct: 192 ATVTVLHALSKEREPYVKRADIVISAVGRPPELYKDNPWRLTGDMIKEGAVVV--GVGGK 249
Query: 180 EDPTKK 197
DP K
Sbjct: 250 VDPATK 255
>UniRef50_Q4A6B1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma synoviae 53|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Mycoplasma synoviae (strain 53)
Length = 278
Score = 39.1 bits (87), Expect = 0.019
Identities = 27/84 (32%), Positives = 46/84 (54%), Gaps = 1/84 (1%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIE- 182
+LK A+V+ T ++ +A+I++VAIG P+ ++ IK GA++ID G N +
Sbjct: 176 ILKRRGASVSTFDENTP--IKLVASADIVIVAIGVPKYIKAENIKQGAIIIDVGTNYDQN 233
Query: 183 DPTKKSGQRLVGDVAYQEAVKVAS 254
DP+ + GDV ++ AS
Sbjct: 234 DPSV-----IFGDVDHESVKTKAS 252
Score = 35.5 bits (78), Expect = 0.23
Identities = 13/20 (65%), Positives = 17/20 (85%)
Frame = +2
Query: 254 AVTPVPGGXGPMTVAMLMRN 313
A+TPVPGG GP+TV L++N
Sbjct: 253 AITPVPGGVGPLTVVCLLKN 272
>UniRef50_Q6KID0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma mobile|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma mobile
Length = 280
Score = 38.7 bits (86), Expect = 0.025
Identities = 17/41 (41%), Positives = 28/41 (68%)
Frame = +3
Query: 72 TKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIEDPTK 194
++ A+IL+VA G P +V+ +K ++VID GIN+I + K
Sbjct: 190 SEEADILIVAAGHPNLVKPENVKNNSIVIDVGINSIGENDK 230
Score = 33.9 bits (74), Expect = 0.70
Identities = 13/20 (65%), Positives = 16/20 (80%)
Frame = +2
Query: 254 AVTPVPGGXGPMTVAMLMRN 313
A++PVPGG GPMTV L +N
Sbjct: 248 AISPVPGGVGPMTVISLFKN 267
>UniRef50_A5IXS7 Cluster: FolD bifunctional protein; n=1; Mycoplasma
agalactiae|Rep: FolD bifunctional protein - Mycoplasma
agalactiae
Length = 286
Score = 37.9 bits (84), Expect = 0.043
Identities = 27/74 (36%), Positives = 43/74 (58%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
LLK A V+ ++K ++ + ++A++LV A G+P++V+ IK GA +ID G IE
Sbjct: 177 LLKKLGAMVST-YNKNTGINGV-ESADLLVSAAGQPDLVKKENIKDGAWLIDAGTTMIER 234
Query: 186 PTKKSGQRLVGDVA 227
KK VGD +
Sbjct: 235 EGKKC---FVGDAS 245
>UniRef50_Q6FWY6 Cluster: Candida glabrata strain CBS138 chromosome
C complete sequence; n=1; Candida glabrata|Rep: Candida
glabrata strain CBS138 chromosome C complete sequence -
Candida glabrata (Yeast) (Torulopsis glabrata)
Length = 769
Score = 33.9 bits (74), Expect = 0.70
Identities = 19/62 (30%), Positives = 34/62 (54%)
Frame = -3
Query: 265 RSHSEATLTASWYATSPTKRCPLFFVGSSIALIPQSITTAPGLIQEPRTISGRPIATTSI 86
+S+S+ +S+ +TS K+ F GSS+ P T +P +++ T + I+TTS
Sbjct: 262 QSNSKHRAKSSFQSTSRVKKARPFSSGSSLLFTPFKSTNSPPVVRTTNTTTSAFISTTSP 321
Query: 85 SA 80
S+
Sbjct: 322 SS 323
>UniRef50_Q6G585 Cluster: Sensor protein; n=3; Bartonella|Rep:
Sensor protein - Bartonella henselae (Rochalimaea
henselae)
Length = 821
Score = 33.1 bits (72), Expect = 1.2
Identities = 16/57 (28%), Positives = 27/57 (47%)
Frame = +2
Query: 122 PRLLDQAWSRRYRLWYQRY*GSYKEKRATFSGRRGIPGGGQSSFAVTPVPGGXGPMT 292
P L Q W W+ ++ + E+R T+SGR + G + + P+P G +T
Sbjct: 514 PLTLRQEWD-----WFTKFITGFAEERDTYSGRMDLKNGMIIDYTLVPLPNGETMLT 565
>UniRef50_A0T555 Cluster: Ornithine cyclodeaminase/mu-crystallin;
n=1; Burkholderia ambifaria MC40-6|Rep: Ornithine
cyclodeaminase/mu-crystallin - Burkholderia ambifaria
MC40-6
Length = 304
Score = 32.7 bits (71), Expect = 1.6
Identities = 21/71 (29%), Positives = 34/71 (47%), Gaps = 6/71 (8%)
Frame = +3
Query: 63 SEITKTAEILVVAIGRPE-MVRGSWIKPGAVVIDCGI-----NAIEDPTKKSGQRLVGDV 224
+E A+I+VVA E ++RG W++PGA V G ++D + + R+V D
Sbjct: 176 AEACAAADIVVVATRASEPVIRGEWLRPGAFVASIGATRPDQRELDDASLLAASRIVVDW 235
Query: 225 AYQEAVKVASL 257
Q + L
Sbjct: 236 MQQTPFETGDL 246
>UniRef50_Q4S6Y9 Cluster: Chromosome 14 SCAF14723, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 14 SCAF14723, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 1066
Score = 32.3 bits (70), Expect = 2.1
Identities = 20/67 (29%), Positives = 32/67 (47%)
Frame = +3
Query: 6 LLKWEHATVTVCHSKTKNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIED 185
L++ + V V +KNL A+ +VV + + +W KPGA+V C D
Sbjct: 164 LIERQGIEVVVSDWTSKNLKSQVMRADAVVVLEAGKKNLPPTWFKPGALVFSC------D 217
Query: 186 PTKKSGQ 206
PT K+ +
Sbjct: 218 PTSKTDE 224
>UniRef50_Q221W9 Cluster: 2-hydroxy-3-oxopropionate reductase; n=1;
Rhodoferax ferrireducens T118|Rep:
2-hydroxy-3-oxopropionate reductase - Rhodoferax
ferrireducens (strain DSM 15236 / ATCC BAA-621 / T118)
Length = 303
Score = 32.3 bits (70), Expect = 2.1
Identities = 19/62 (30%), Positives = 35/62 (56%), Gaps = 9/62 (14%)
Frame = +3
Query: 54 KNLSEITKTAEILVVAI-GRP---EMVRGSW-----IKPGAVVIDCGINAIEDPTKKSGQ 206
K +E+ TA+++++ + G P E+V G +KPG VV+DC ++ D T++ Q
Sbjct: 59 KTAAEVAATADVIIICVTGSPQVEEVVFGDTGILQTLKPGCVVVDCS-TSLPDSTRRVAQ 117
Query: 207 RL 212
+
Sbjct: 118 AI 119
>UniRef50_Q5H851 Cluster: Putative uncharacterized protein; n=1;
Streptococcus suis|Rep: Putative uncharacterized protein
- Streptococcus suis
Length = 188
Score = 31.9 bits (69), Expect = 2.8
Identities = 22/60 (36%), Positives = 33/60 (55%)
Frame = -3
Query: 250 ATLTASWYATSPTKRCPLFFVGSSIALIPQSITTAPGLIQEPRTISGRPIATTSISAVLV 71
A L +S TS + LF S + ++TT PGLI EP TI+ P+ ++I+ VL+
Sbjct: 1 AELFSSTATTSASAESELFPTSS----LEYAVTTVPGLITEPGTIT-CPVTGSTITTVLL 55
>UniRef50_Q12DQ7 Cluster: Ornithine cyclodeaminase/mu-crystallin;
n=1; Polaromonas sp. JS666|Rep: Ornithine
cyclodeaminase/mu-crystallin - Polaromonas sp. (strain
JS666 / ATCC BAA-500)
Length = 320
Score = 31.9 bits (69), Expect = 2.8
Identities = 23/70 (32%), Positives = 32/70 (45%), Gaps = 6/70 (8%)
Frame = +3
Query: 24 ATVTVCHSKTKNLSEITKTAEILVVAIGRPEMV-RGSWIKPGAVVIDCGINA-----IED 185
A T C A+I+V A E V GSW+KPGA+V GI+A ++D
Sbjct: 164 ALQTGCRVNLCGAEAAVHDADIVVTATRSLEPVFDGSWLKPGALVSAIGISAPKGRELDD 223
Query: 186 PTKKSGQRLV 215
T R++
Sbjct: 224 ATLSRASRII 233
>UniRef50_A4H5B9 Cluster: Putative uncharacterized protein; n=1;
Leishmania braziliensis|Rep: Putative uncharacterized
protein - Leishmania braziliensis
Length = 1878
Score = 31.5 bits (68), Expect = 3.7
Identities = 15/25 (60%), Positives = 18/25 (72%)
Frame = -3
Query: 256 SEATLTASWYATSPTKRCPLFFVGS 182
+EAT TA+WYA+SP P FF GS
Sbjct: 1608 AEAT-TAAWYASSPVGYPPSFFAGS 1631
>UniRef50_A7D849 Cluster: Metal-dependent phosphohydrolase, HD sub
domain; n=1; Halorubrum lacusprofundi ATCC 49239|Rep:
Metal-dependent phosphohydrolase, HD sub domain -
Halorubrum lacusprofundi ATCC 49239
Length = 771
Score = 31.5 bits (68), Expect = 3.7
Identities = 17/51 (33%), Positives = 25/51 (49%)
Frame = -3
Query: 241 TASWYATSPTKRCPLFFVGSSIALIPQSITTAPGLIQEPRTISGRPIATTS 89
T +W SP+ P +S+ + A +I +PR S RPIATT+
Sbjct: 7 TPNWRPVSPS-HSPAIGNATSVTASKRRTVAAANVIADPRASSTRPIATTA 56
>UniRef50_UPI0000F21FF3 Cluster: PREDICTED: similar to ZNF336; n=1;
Danio rerio|Rep: PREDICTED: similar to ZNF336 - Danio
rerio
Length = 763
Score = 31.1 bits (67), Expect = 4.9
Identities = 19/58 (32%), Positives = 29/58 (50%), Gaps = 1/58 (1%)
Frame = +3
Query: 12 KWEHATVTVCHSKTKNL-SEITKTAEILVVAIGRPEMVRGSWIKPGAVVIDCGINAIE 182
K E A V SK + L S++ KT E++ IG P + G W G + + G+ I+
Sbjct: 583 KKEKAAAAV--SKAQALQSDVGKTQEVMAT-IGEPVTISGDWTGSGTIALVSGLTVIQ 637
>UniRef50_A7DIP1 Cluster: Diguanylate cyclase/phosphodiesterase with
PAS/PAC and GAF sensor; n=2; Methylobacterium extorquens
PA1|Rep: Diguanylate cyclase/phosphodiesterase with
PAS/PAC and GAF sensor - Methylobacterium extorquens PA1
Length = 817
Score = 31.1 bits (67), Expect = 4.9
Identities = 12/26 (46%), Positives = 19/26 (73%)
Frame = +3
Query: 51 TKNLSEITKTAEILVVAIGRPEMVRG 128
T+ L+++ +TAE LV A+GRP + G
Sbjct: 461 TRTLAQVAETAERLVAALGRPFQIEG 486
>UniRef50_A4AHV5 Cluster: Putative uncharacterized protein; n=1;
marine actinobacterium PHSC20C1|Rep: Putative
uncharacterized protein - marine actinobacterium
PHSC20C1
Length = 330
Score = 31.1 bits (67), Expect = 4.9
Identities = 14/34 (41%), Positives = 19/34 (55%)
Frame = -3
Query: 142 GLIQEPRTISGRPIATTSISAVLVISLKFLVFEW 41
GLI +PRTI+G P+ + L I+L L W
Sbjct: 51 GLIVDPRTITGAPLWAKPLKFALSIALYSLTLSW 84
>UniRef50_Q4DSZ0 Cluster: Putative uncharacterized protein; n=3;
Trypanosoma cruzi|Rep: Putative uncharacterized protein
- Trypanosoma cruzi
Length = 808
Score = 31.1 bits (67), Expect = 4.9
Identities = 18/56 (32%), Positives = 27/56 (48%), Gaps = 3/56 (5%)
Frame = +3
Query: 3 ELLKWEHATVTVCHSKT---KNLSEITKTAEILVVAIGRPEMVRGSWIKPGAVVID 161
E+ + HATV C S T NL+ + ++ + + +VRG WI P V D
Sbjct: 657 EIKQLPHATVAECRSNTPVPSNLTHLITNGQLTIKLL--TALVRGCWILPDVYVRD 710
>UniRef50_Q7S326 Cluster: Putative uncharacterized protein
NCU09189.1; n=1; Neurospora crassa|Rep: Putative
uncharacterized protein NCU09189.1 - Neurospora crassa
Length = 651
Score = 31.1 bits (67), Expect = 4.9
Identities = 14/44 (31%), Positives = 24/44 (54%), Gaps = 1/44 (2%)
Frame = +3
Query: 114 EMVRGSWIKPGAVVIDCGIN-AIEDPTKKSGQRLVGDVAYQEAV 242
+++RG W P VID G++ + +PT K +G +EA+
Sbjct: 337 KLIRGGWCSPSVAVIDFGVSYPVTEPTGKGTGIPLGYAPPEEAI 380
>UniRef50_Q6YQB8 Cluster: ABC-type amino acid transport system,
periplasmic component; n=2; Candidatus Phytoplasma
asteris|Rep: ABC-type amino acid transport system,
periplasmic component - Onion yellows phytoplasma
Length = 609
Score = 30.7 bits (66), Expect = 6.5
Identities = 15/37 (40%), Positives = 21/37 (56%)
Frame = -3
Query: 139 LIQEPRTISGRPIATTSISAVLVISLKFLVFEWHTVT 29
+ Q+ I I T SIS++L++ L F VF WH T
Sbjct: 17 IFQKKNNIKIFKIITLSISSILLVWLHFSVFGWHFST 53
>UniRef50_A5D4V4 Cluster: Trehalose-6-phosphate synthase; n=1;
Pelotomaculum thermopropionicum SI|Rep:
Trehalose-6-phosphate synthase - Pelotomaculum
thermopropionicum SI
Length = 525
Score = 30.7 bits (66), Expect = 6.5
Identities = 12/26 (46%), Positives = 17/26 (65%), Gaps = 1/26 (3%)
Frame = +1
Query: 46 QRLRI*VKLLRQQK-YWWWRSVVQRW 120
+RL K++R+Q +WWWR V Q W
Sbjct: 450 RRLAALSKVIREQDIHWWWRKVRQSW 475
>UniRef50_A4Z040 Cluster: Putative branched-chain amino acid ABC
transporter, permease protein; n=1; Bradyrhizobium sp.
ORS278|Rep: Putative branched-chain amino acid ABC
transporter, permease protein - Bradyrhizobium sp.
(strain ORS278)
Length = 343
Score = 30.7 bits (66), Expect = 6.5
Identities = 14/37 (37%), Positives = 24/37 (64%), Gaps = 3/37 (8%)
Frame = -3
Query: 142 GLIQEPRTISGRPIATT---SISAVLVISLKFLVFEW 41
GL+ P T+ G+PI T +I A++++ + FLV +W
Sbjct: 134 GLLIRPMTVLGQPIQTDQGYAIVAIVLLLVTFLVMQW 170
>UniRef50_A1ZUI3 Cluster: Tetrahydrofolate
dehydrogenase/cyclohydrolase, NAD(P)-binding domain;
n=1; Microscilla marina ATCC 23134|Rep: Tetrahydrofolate
dehydrogenase/cyclohydrolase, NAD(P)-binding domain -
Microscilla marina ATCC 23134
Length = 233
Score = 30.7 bits (66), Expect = 6.5
Identities = 12/17 (70%), Positives = 15/17 (88%)
Frame = +2
Query: 257 VTPVPGGXGPMTVAMLM 307
VTPVPGG GP+ +A+LM
Sbjct: 179 VTPVPGGTGPVEMAVLM 195
>UniRef50_A1UHY6 Cluster: Cytochrome P450; n=5; Mycobacterium|Rep:
Cytochrome P450 - Mycobacterium sp. (strain KMS)
Length = 485
Score = 30.7 bits (66), Expect = 6.5
Identities = 15/46 (32%), Positives = 24/46 (52%)
Frame = -2
Query: 224 HVAH*TLPAFLCRILNSVDTTVYNDGSRLDPRASDHLWTTDRHHQY 87
H+ TL A + +N D T+++D R DP D D+HH++
Sbjct: 377 HIPSNTLCA-ITPAVNHFDRTIWSDPERFDPSRFDEPRREDQHHRF 421
>UniRef50_A2WN32 Cluster: Putative uncharacterized protein; n=2;
Oryza sativa|Rep: Putative uncharacterized protein -
Oryza sativa subsp. indica (Rice)
Length = 286
Score = 30.7 bits (66), Expect = 6.5
Identities = 17/44 (38%), Positives = 21/44 (47%), Gaps = 3/44 (6%)
Frame = +3
Query: 105 GRPEMVRGS---WIKPGAVVIDCGINAIEDPTKKSGQRLVGDVA 227
G P V G W KPG V G++A+ P + GQR G A
Sbjct: 153 GMPPTVAGESVVWCKPGVVAKLMGLDAVPVPVRGGGQRRGGAAA 196
>UniRef50_Q2UFW7 Cluster: Predicted protein; n=2;
Trichocomaceae|Rep: Predicted protein - Aspergillus
oryzae
Length = 681
Score = 30.7 bits (66), Expect = 6.5
Identities = 12/29 (41%), Positives = 16/29 (55%)
Frame = +1
Query: 70 LLRQQKYWWWRSVVQRWSEALGSSLEPSL 156
+L + WWW S V R + LG +PSL
Sbjct: 289 ILHRHSSWWWTSCVVRHCQQLGVHHQPSL 317
>UniRef50_UPI0000DD7AFF Cluster: PREDICTED: hypothetical protein;
n=4; Catarrhini|Rep: PREDICTED: hypothetical protein -
Homo sapiens
Length = 285
Score = 30.3 bits (65), Expect = 8.6
Identities = 25/59 (42%), Positives = 30/59 (50%), Gaps = 2/59 (3%)
Frame = -3
Query: 274 ARXRSHSEATLTASWYATS-PTKRCPLFFVGSSIALIPQ-SITTAPGLIQEPRTISGRP 104
AR S L A +AT P PL GSS+ L+P S TAPG EP + +GRP
Sbjct: 132 ARQPSGKNRPLPAPQHATKKPGAPTPL---GSSVRLLPYISRGTAPGDTVEPASGAGRP 187
>UniRef50_Q19Z55 Cluster: Gp31; n=3; Viruses|Rep: Gp31 -
Mycobacterium phage Qyrzula
Length = 401
Score = 30.3 bits (65), Expect = 8.6
Identities = 13/29 (44%), Positives = 16/29 (55%)
Frame = +2
Query: 212 SGRRGIPGGGQSSFAVTPVPGGXGPMTVA 298
SG +PGGG + V+ PGG G VA
Sbjct: 367 SGNGNVPGGGGAGAVVSTTPGGTGARGVA 395
>UniRef50_P20129 Cluster: 70 kDa protein; n=1; Eggplant mosaic
virus|Rep: 70 kDa protein - Eggplant mosaic virus
Length = 649
Score = 30.3 bits (65), Expect = 8.6
Identities = 24/94 (25%), Positives = 39/94 (41%), Gaps = 1/94 (1%)
Frame = -2
Query: 296 PRSWAPXRPXQESQRSYFD-RLLVCHVAH*TLPAFLCRILNSVDTTVYNDGSRLDPRASD 120
PRS +P P ++ R + + L C + PAF C + +V + PR
Sbjct: 62 PRSHSPPPPNPQNSRDFSPVQSLACSRS----PAFNCDVHETVQVSKTCGSKPKIPRVDQ 117
Query: 119 HLWTTDRHHQYFCCLSNFTQILSL*MAHCDSSVF 18
RHH L++F++ +L A C +F
Sbjct: 118 LSTHCRRHHSLPLHLTHFSKQFNLLHARCSDVLF 151
>UniRef50_Q6NRM6 Cluster: DNA replication licensing factor MCM9;
n=1; Xenopus laevis|Rep: DNA replication licensing
factor MCM9 - Xenopus laevis (African clawed frog)
Length = 1143
Score = 30.3 bits (65), Expect = 8.6
Identities = 11/28 (39%), Positives = 16/28 (57%)
Frame = -2
Query: 134 PRASDHLWTTDRHHQYFCCLSNFTQILS 51
PR SD LW+ ++ YFC + N +S
Sbjct: 513 PRKSDKLWSMEKMKTYFCLIKNLQPKMS 540
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 318,387,361
Number of Sequences: 1657284
Number of extensions: 5541254
Number of successful extensions: 19081
Number of sequences better than 10.0: 118
Number of HSP's better than 10.0 without gapping: 18405
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 19057
length of database: 575,637,011
effective HSP length: 83
effective length of database: 438,082,439
effective search space used: 10075896097
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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