Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fbS20314
(412 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q9XYB0 Cluster: PugilistDominant; n=2; Coelomata|Rep: P... 79 3e-14
UniRef50_UPI00015B59A5 Cluster: PREDICTED: similar to ENSANGP000... 71 1e-11
UniRef50_P11586 Cluster: C-1-tetrahydrofolate synthase, cytoplas... 68 7e-11
UniRef50_Q4T2B9 Cluster: Chromosome undetermined SCAF10300, whol... 59 3e-08
UniRef50_Q63SL6 Cluster: Bifunctional protein folD [Includes: Me... 55 6e-07
UniRef50_Q21285 Cluster: Dauer or aging adult overexpression pro... 54 1e-06
UniRef50_A1AL91 Cluster: Bifunctional protein folD [Includes: Me... 50 2e-05
UniRef50_Q83FS2 Cluster: Bifunctional protein folD [Includes: Me... 49 4e-05
UniRef50_Q5IWX9 Cluster: Plastid 5,10-methylene-tetrahydrofolate... 46 3e-04
UniRef50_O65271 Cluster: F6N23.26 protein; n=20; Viridiplantae|R... 45 5e-04
UniRef50_Q74GN1 Cluster: Bifunctional protein folD 1 [Includes: ... 45 5e-04
UniRef50_Q9LHH7 Cluster: 5,10-methylenetetrahydrofolate dehydrog... 45 7e-04
UniRef50_O83714 Cluster: Bifunctional protein folD [Includes: Me... 45 7e-04
UniRef50_Q8KN38 Cluster: Bifunctional protein folD [Includes: Me... 45 7e-04
UniRef50_Q24UZ7 Cluster: Bifunctional protein folD 2 [Includes: ... 45 7e-04
UniRef50_P13995 Cluster: Bifunctional methylenetetrahydrofolate ... 44 0.001
UniRef50_Q5PBL6 Cluster: Bifunctional protein folD [Includes: Me... 44 0.001
UniRef50_O65269 Cluster: F6N23.28 protein; n=1; Arabidopsis thal... 43 0.002
UniRef50_Q6D2E6 Cluster: Bifunctional protein folD [Includes: Me... 43 0.002
UniRef50_O84081 Cluster: Bifunctional protein folD [Includes: Me... 43 0.002
UniRef50_Q9A8Y0 Cluster: Bifunctional protein folD [Includes: Me... 43 0.002
UniRef50_Q54VK0 Cluster: Methenyl tetrahydrofolate cyclohydrolas... 43 0.003
UniRef50_Q7MVE9 Cluster: Bifunctional protein folD [Includes: Me... 42 0.004
UniRef50_A7D6I9 Cluster: Methenyltetrahydrofolate cyclohydrolase... 42 0.006
UniRef50_Q8DMU0 Cluster: Bifunctional protein folD [Includes: Me... 42 0.006
UniRef50_Q0AZF5 Cluster: Bifunctional protein folD 1 [Includes: ... 42 0.006
UniRef50_Q86F84 Cluster: Clone ZZD1003 mRNA sequence; n=1; Schis... 41 0.009
UniRef50_UPI000038C811 Cluster: COG0190: 5,10-methylene-tetrahyd... 40 0.015
UniRef50_Q9ZD32 Cluster: Bifunctional protein folD [Includes: Me... 40 0.015
UniRef50_Q3YRE3 Cluster: Bifunctional protein folD [Includes: Me... 40 0.020
UniRef50_Q6ALZ5 Cluster: Bifunctional protein folD [Includes: Me... 40 0.020
UniRef50_Q0SFQ8 Cluster: Bifunctional protein folD 1 [Includes: ... 40 0.020
UniRef50_Q6F9E6 Cluster: Bifunctional protein folD 1 [Includes: ... 40 0.020
UniRef50_Q16F77 Cluster: Methylenetetrahydrofolate dehydrogenase... 40 0.026
UniRef50_A7DNA7 Cluster: Methylenetetrahydrofolate dehydrogenase... 40 0.026
UniRef50_P47259 Cluster: Bifunctional protein folD [Includes: Me... 40 0.026
UniRef50_Q8EQ43 Cluster: Bifunctional protein folD [Includes: Me... 39 0.034
UniRef50_Q5FJG5 Cluster: Bifunctional protein folD [Includes: Me... 39 0.034
UniRef50_Q4S6Y9 Cluster: Chromosome 14 SCAF14723, whole genome s... 39 0.046
UniRef50_A1HML1 Cluster: Methenyltetrahydrofolate cyclohydrolase... 39 0.046
UniRef50_Q9KQQ6 Cluster: Bifunctional protein folD [Includes: Me... 39 0.046
UniRef50_Q4FNW1 Cluster: Bifunctional protein folD [Includes: Me... 39 0.046
UniRef50_UPI00015B49ED Cluster: PREDICTED: similar to putative g... 38 0.060
UniRef50_A4EAK0 Cluster: Putative uncharacterized protein; n=3; ... 38 0.060
UniRef50_Q2UUX1 Cluster: RIB40 genomic DNA, SC009; n=1; Aspergil... 38 0.060
UniRef50_A0JTZ0 Cluster: Bifunctional protein folD [Includes: Me... 38 0.060
UniRef50_Q74J95 Cluster: Bifunctional protein folD 1 [Includes: ... 38 0.080
UniRef50_Q2B9L0 Cluster: Bifunctional protein FolD; n=1; Bacillu... 38 0.11
UniRef50_Q3AYX2 Cluster: Bifunctional protein folD [Includes: Me... 38 0.11
UniRef50_Q1II76 Cluster: Bifunctional protein folD [Includes: Me... 38 0.11
UniRef50_A3PVV6 Cluster: Bifunctional protein folD [Includes: Me... 37 0.18
UniRef50_Q6BNW9 Cluster: Debaryomyces hansenii chromosome E of s... 36 0.24
UniRef50_Q4FTX6 Cluster: Bifunctional protein folD [Includes: Me... 36 0.24
UniRef50_A5CF58 Cluster: Bifunctional protein folD [Includes: Me... 36 0.24
UniRef50_Q8TK95 Cluster: Bifunctional protein folD [Includes: Me... 36 0.24
UniRef50_Q97HC9 Cluster: Bifunctional protein folD [Includes: Me... 36 0.24
UniRef50_Q4RT28 Cluster: Chromosome 12 SCAF14999, whole genome s... 36 0.32
UniRef50_Q5SJ94 Cluster: Bifunctional protein folD [Includes: Me... 36 0.42
UniRef50_Q8RAD0 Cluster: Bifunctional protein folD [Includes: Me... 35 0.56
UniRef50_P56467 Cluster: Bifunctional protein folD [Includes: Me... 35 0.56
UniRef50_Q9HPY4 Cluster: Bifunctional protein folD [Includes: Me... 35 0.74
UniRef50_Q6F1V0 Cluster: Bifunctional protein folD [Includes: Me... 34 0.98
UniRef50_Q057D7 Cluster: Bifunctional protein folD [Includes: Me... 34 1.3
UniRef50_Q6MI74 Cluster: Bifunctional protein folD [Includes: Me... 33 2.3
UniRef50_UPI0000DB7ABF Cluster: PREDICTED: similar to Bifunction... 33 3.0
UniRef50_Q1NQA0 Cluster: 4-diphosphocytidyl-2C-methyl-D-erythrit... 32 4.0
UniRef50_Q7TU81 Cluster: Bifunctional protein folD [Includes: Me... 32 4.0
UniRef50_Q3A1Q7 Cluster: Bifunctional protein folD [Includes: Me... 32 4.0
UniRef50_Q54Z91 Cluster: Methylenetetrahydrofolate dehydrogenase... 32 5.2
UniRef50_Q4A6B1 Cluster: Bifunctional protein folD [Includes: Me... 32 5.2
UniRef50_A3M3Q9 Cluster: Putative flavin-binding monooxygenase; ... 31 6.9
UniRef50_Q016N9 Cluster: 5'-3' exoribonuclease 1; n=2; Ostreococ... 31 6.9
UniRef50_Q979W3 Cluster: Bifunctional protein folD [Includes: Me... 31 6.9
UniRef50_Q14NV1 Cluster: Bifunctional protein folD [Includes: Me... 31 6.9
UniRef50_Q8ZZK1 Cluster: Bifunctional protein folD [Includes: Me... 31 6.9
UniRef50_UPI0000585CF2 Cluster: PREDICTED: similar to beta spect... 31 9.1
>UniRef50_Q9XYB0 Cluster: PugilistDominant; n=2; Coelomata|Rep:
PugilistDominant - Drosophila melanogaster (Fruit fly)
Length = 268
Score = 79.4 bits (187), Expect = 3e-14
Identities = 36/52 (69%), Positives = 41/52 (78%)
Frame = +1
Query: 256 EIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLNT 411
E+EL KI LNE P VHGIIVQMPLD D ID+HR+TDAVSP+K DGL+T
Sbjct: 78 EVELLDKINDLNEDPRVHGIIVQMPLDCDTPIDSHRITDAVSPEKDVDGLHT 129
Score = 73.3 bits (172), Expect = 2e-12
Identities = 38/73 (52%), Positives = 46/73 (63%)
Frame = +2
Query: 35 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLXXXXXX 214
A+IISG VA SI +LR +VT + + + F P L IVQVGGREDSNVYIRMK+
Sbjct: 4 AKIISGTAVAKSIREELRNEVTAMSKQLADFVPGLRIVQVGGREDSNVYIRMKIKAATEI 63
Query: 215 XXXXEHXRLPRDI 253
H +LPR I
Sbjct: 64 GIDAAHVQLPRSI 76
>UniRef50_UPI00015B59A5 Cluster: PREDICTED: similar to
ENSANGP00000016878; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000016878 - Nasonia
vitripennis
Length = 866
Score = 70.5 bits (165), Expect = 1e-11
Identities = 32/52 (61%), Positives = 37/52 (71%)
Frame = +1
Query: 256 EIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLNT 411
E EL K+ LN P HGIIVQMPLDS + I++H +TD VSPDK DGLNT
Sbjct: 81 EHELLTKLNKLNNDPDTHGIIVQMPLDSVNKINSHLITDTVSPDKDVDGLNT 132
Score = 62.1 bits (144), Expect = 4e-09
Identities = 29/68 (42%), Positives = 40/68 (58%)
Frame = +2
Query: 41 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLXXXXXXXX 220
++SG ++A I L + V ++ K + P LAIVQVGGREDSNVYIRMK+
Sbjct: 9 VLSGTDLAKEIRESLAKDVAAIQQKLPNYAPGLAIVQVGGREDSNVYIRMKIKAASEIGI 68
Query: 221 XXEHXRLP 244
H ++P
Sbjct: 69 KATHVKMP 76
>UniRef50_P11586 Cluster: C-1-tetrahydrofolate synthase, cytoplasmic
(C1-THF synthase) [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate
synthetase (EC 6.3.4.3)]; n=86; cellular organisms|Rep:
C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF
synthase) [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate
synthetase (EC 6.3.4.3)] - Homo sapiens (Human)
Length = 935
Score = 68.1 bits (159), Expect = 7e-11
Identities = 32/71 (45%), Positives = 46/71 (64%)
Frame = +2
Query: 35 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLXXXXXX 214
A+I++G E++ I L+ QVT+L+ + GF PRLAI+QVG R+DSN+YI +KL
Sbjct: 4 AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63
Query: 215 XXXXEHXRLPR 247
H +LPR
Sbjct: 64 GIKATHIKLPR 74
Score = 57.6 bits (133), Expect = 9e-08
Identities = 25/52 (48%), Positives = 37/52 (71%)
Frame = +1
Query: 256 EIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLNT 411
E E+ ITSLNE +VHG +VQ+PLDS++ I+ V +A++P+K DGL +
Sbjct: 78 ESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKDVDGLTS 129
>UniRef50_Q4T2B9 Cluster: Chromosome undetermined SCAF10300, whole
genome shotgun sequence; n=6; Clupeocephala|Rep:
Chromosome undetermined SCAF10300, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 348
Score = 59.3 bits (137), Expect = 3e-08
Identities = 27/49 (55%), Positives = 35/49 (71%)
Frame = +1
Query: 262 ELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
E+ I S+NE SVHG+IVQ+PLDS H ID+ +T+ VS DK DGL+
Sbjct: 126 EVLLNILSINEDQSVHGLIVQLPLDSVHHIDSECITNTVSADKDVDGLS 174
Score = 33.5 bits (73), Expect = 1.7
Identities = 20/54 (37%), Positives = 29/54 (53%)
Frame = +2
Query: 83 LRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLXXXXXXXXXXEHXRLP 244
L Q++ RL S F + ++QVG R+DSN+YI K+ +H RLP
Sbjct: 68 LGQKLLRLLVLTSVF--LVTLLQVGDRDDSNLYISAKMKAAAEIGIDAKHVRLP 119
>UniRef50_Q63SL6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=226; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Burkholderia pseudomallei (Pseudomonas
pseudomallei)
Length = 285
Score = 54.8 bits (126), Expect = 6e-07
Identities = 24/51 (47%), Positives = 36/51 (70%)
Frame = +1
Query: 256 EIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
E EL A+I LN P +HGI+VQ+PL + ID+H+V +A++P+K DG +
Sbjct: 75 EPELLARIDELNRDPKIHGILVQLPLPA--HIDSHKVIEAIAPEKDVDGFH 123
>UniRef50_Q21285 Cluster: Dauer or aging adult overexpression
protein 3; n=2; Caenorhabditis|Rep: Dauer or aging adult
overexpression protein 3 - Caenorhabditis elegans
Length = 303
Score = 54.0 bits (124), Expect = 1e-06
Identities = 28/74 (37%), Positives = 41/74 (55%)
Frame = +2
Query: 32 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLXXXXX 211
+A+I+SG+E + + +D+ Q++ + R F LAIVQVG R DSNVYI KL
Sbjct: 2 VAEIVSGLEYSKKVLHDVGQKIAKTREHHPNFHAVLAIVQVGNRSDSNVYINSKLKKAKE 61
Query: 212 XXXXXEHXRLPRDI 253
+ +LP I
Sbjct: 62 IGADGKLIKLPDTI 75
Score = 48.4 bits (110), Expect = 6e-05
Identities = 22/48 (45%), Positives = 29/48 (60%)
Frame = +1
Query: 262 ELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGL 405
+L +I +LN + GII+Q+PLD H IDA V D + P K DGL
Sbjct: 79 DLKREIMALNHDNEIDGIIIQLPLDCKHEIDADSVIDLIDPLKDVDGL 126
>UniRef50_A1AL91 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=9; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Pelobacter propionicus (strain DSM 2379)
Length = 283
Score = 49.6 bits (113), Expect = 2e-05
Identities = 24/51 (47%), Positives = 32/51 (62%)
Frame = +1
Query: 256 EIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
E EL A + LN P +HGI+VQ+PL S ID +V +A+SP K DG +
Sbjct: 74 EAELLALVELLNNDPKIHGILVQLPLPSQ--IDTDKVLEAISPFKDVDGFH 122
>UniRef50_Q83FS2 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Tropheryma whipplei|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Tropheryma whipplei (strain Twist)
(Whipple's bacillus)
Length = 295
Score = 48.8 bits (111), Expect = 4e-05
Identities = 25/51 (49%), Positives = 34/51 (66%)
Frame = +1
Query: 256 EIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
E EL +K+ LN S V GIIVQ+PL ID ++V +A++PDK DGL+
Sbjct: 75 EKELISKVEILNASSDVSGIIVQLPLPES--IDQNKVIEAINPDKDADGLH 123
>UniRef50_Q5IWX9 Cluster: Plastid 5,10-methylene-tetrahydrofolate
dehydrogenase; n=1; Prototheca wickerhamii|Rep: Plastid
5,10-methylene-tetrahydrofolate dehydrogenase -
Prototheca wickerhamii
Length = 248
Score = 46.0 bits (104), Expect = 3e-04
Identities = 23/51 (45%), Positives = 34/51 (66%)
Frame = +1
Query: 256 EIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
E E+ A + N+ P+VHGI+VQ+PL +H I+ RV DA+S +K DG +
Sbjct: 135 EEEVLAVVAKFNDDPNVHGILVQLPL-PEH-INEKRVLDAISLEKDVDGFH 183
Score = 42.7 bits (96), Expect = 0.003
Identities = 22/56 (39%), Positives = 36/56 (64%)
Frame = +2
Query: 26 AKMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMK 193
A A +I G ++A +I +L+ +V LR++++ P LA+V VG R+DS Y+R K
Sbjct: 59 AMPAALIDGKKIAETIRGELKVEVDELRAQYNTV-PGLAVVLVGERKDSQTYVRSK 113
>UniRef50_O65271 Cluster: F6N23.26 protein; n=20; Viridiplantae|Rep:
F6N23.26 protein - Arabidopsis thaliana (Mouse-ear
cress)
Length = 360
Score = 45.2 bits (102), Expect = 5e-04
Identities = 22/57 (38%), Positives = 34/57 (59%)
Frame = +1
Query: 238 LTKGHHEIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
L + E E+ ++ N+ PSVHGI+VQ+PL S +D + +AVS +K DG +
Sbjct: 136 LAEDSSEEEVLKSVSGFNDDPSVHGILVQLPLPS--HMDEQNILNAVSIEKDVDGFH 190
Score = 37.9 bits (84), Expect = 0.080
Identities = 20/53 (37%), Positives = 32/53 (60%)
Frame = +2
Query: 35 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMK 193
A +I G VA I +++ +V+R++ G P LA++ VG R+DS Y+R K
Sbjct: 69 AIVIDGKAVAKKIRDEITIEVSRMKES-IGVIPGLAVILVGDRKDSATYVRNK 120
>UniRef50_Q74GN1 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Bacteria|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Geobacter sulfurreducens
Length = 290
Score = 45.2 bits (102), Expect = 5e-04
Identities = 22/51 (43%), Positives = 32/51 (62%)
Frame = +1
Query: 256 EIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
E EL AKI +NE P+ G+IVQ+PL I+ V +A++P+K DG +
Sbjct: 74 ESELLAKIKEVNEDPTTDGLIVQLPLPK--HINQQHVINAIAPEKDIDGFH 122
>UniRef50_Q9LHH7 Cluster: 5,10-methylenetetrahydrofolate
dehydrogenase/5,10- methenyltetrahydrofolate
cyclohydrolase; n=7; Eukaryota|Rep:
5,10-methylenetetrahydrofolate dehydrogenase/5,10-
methenyltetrahydrofolate cyclohydrolase - Arabidopsis
thaliana (Mouse-ear cress)
Length = 299
Score = 44.8 bits (101), Expect = 7e-04
Identities = 22/51 (43%), Positives = 32/51 (62%)
Frame = +1
Query: 256 EIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
E +L +K+ LN +P VHGI+VQ+PL H + H + A+S DK DG +
Sbjct: 82 EADLISKVHELNSNPDVHGILVQLPLPK-HINEEH-ILGAISIDKDVDGFH 130
>UniRef50_O83714 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Treponema pallidum
Length = 315
Score = 44.8 bits (101), Expect = 7e-04
Identities = 24/63 (38%), Positives = 35/63 (55%)
Frame = +1
Query: 220 RRRTYXLTKGHHEIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXD 399
R T+ L ++ I LNE VHGI++Q+PL + +DA RV AV+P+K D
Sbjct: 64 RGETHRLPAHASHAQVLELIARLNEDARVHGILIQLPLPA--HLDAARVCRAVAPEKDVD 121
Query: 400 GLN 408
G +
Sbjct: 122 GFH 124
>UniRef50_Q8KN38 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Sphingobium chlorophenolicum|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Sphingobium
chlorophenolicum
Length = 316
Score = 44.8 bits (101), Expect = 7e-04
Identities = 23/51 (45%), Positives = 31/51 (60%)
Frame = +1
Query: 256 EIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
E +L A I SLN VHGI+VQ+PL + ID+ +V D + P K DG +
Sbjct: 75 EEDLLALIASLNADERVHGILVQLPLPAQ--IDSGKVLDTIDPRKDVDGFH 123
Score = 41.5 bits (93), Expect = 0.006
Identities = 26/73 (35%), Positives = 34/73 (46%)
Frame = +2
Query: 32 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLXXXXX 211
MA IISG A + DL + V R S+ G+ P L V VG S++Y+R K+
Sbjct: 1 MASIISGTAAAEGLLADLTRDVARF-SQVHGYAPTLVAVLVGDDPASHIYVRKKIEQCRK 59
Query: 212 XXXXXEHXRLPRD 250
RLP D
Sbjct: 60 VGMESVEHRLPAD 72
>UniRef50_Q24UZ7 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Peptococcaceae|Rep: Bifunctional protein folD 2
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Desulfitobacterium hafniense (strain Y51)
Length = 284
Score = 44.8 bits (101), Expect = 7e-04
Identities = 23/51 (45%), Positives = 31/51 (60%)
Frame = +1
Query: 256 EIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
E + A I SLN +P VHGI++++PL I RV AV PDK DG++
Sbjct: 74 EESILALIDSLNANPDVHGIMIELPLPK--HISKERVMAAVRPDKDVDGVH 122
Score = 38.3 bits (85), Expect = 0.060
Identities = 22/73 (30%), Positives = 38/73 (52%)
Frame = +2
Query: 32 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLXXXXX 211
MAQ++ G E++ ++ +++++V R + + G P+LA+V VG S VY + K
Sbjct: 1 MAQLLDGKEISKVLKEEIKEEVKRWKEQ--GVNPKLAVVLVGDDPASVVYAKSKQKVSDS 58
Query: 212 XXXXXEHXRLPRD 250
E LP D
Sbjct: 59 LGIDFELTVLPAD 71
>UniRef50_P13995 Cluster: Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor
[Includes: NAD-dependent methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)]; n=66; cellular
organisms|Rep: Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor
[Includes: NAD-dependent methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Homo sapiens (Human)
Length = 350
Score = 44.4 bits (100), Expect = 0.001
Identities = 24/51 (47%), Positives = 32/51 (62%)
Frame = +1
Query: 256 EIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
E EL I LN +V G++VQ+PL +H ID R+ +AVSPDK DG +
Sbjct: 110 EEELLNLINKLNNDDNVDGLLVQLPLP-EH-IDERRICNAVSPDKDVDGFH 158
>UniRef50_Q5PBL6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Alphaproteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Anaplasma marginale (strain St. Maries)
Length = 299
Score = 44.4 bits (100), Expect = 0.001
Identities = 25/61 (40%), Positives = 33/61 (54%)
Frame = +1
Query: 226 RTYXLTKGHHEIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGL 405
RT L + EL I LN +VHGI+VQ+PL ID V +A+SP+K DG
Sbjct: 65 RTIALEHDTSQEELLRIIDELNRDAAVHGILVQLPL--PRHIDKELVINAISPEKDVDGF 122
Query: 406 N 408
+
Sbjct: 123 H 123
>UniRef50_O65269 Cluster: F6N23.28 protein; n=1; Arabidopsis
thaliana|Rep: F6N23.28 protein - Arabidopsis thaliana
(Mouse-ear cress)
Length = 310
Score = 43.2 bits (97), Expect = 0.002
Identities = 20/51 (39%), Positives = 32/51 (62%)
Frame = +1
Query: 256 EIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
E E+ ++ N+ PSVHG++VQ+PL S +D + +AVS +K DG +
Sbjct: 92 EEEVLKYVSGFNDDPSVHGVLVQLPLPS--HMDEQNILNAVSIEKDVDGFH 140
>UniRef50_Q6D2E6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Erwinia carotovora subsp. atroseptica (Pectobacterium
atrosepticum)
Length = 287
Score = 43.2 bits (97), Expect = 0.002
Identities = 24/61 (39%), Positives = 34/61 (55%)
Frame = +1
Query: 226 RTYXLTKGHHEIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGL 405
R+Y L E EL A I LN ++ GI+VQ+PL ID +V + ++PDK DG
Sbjct: 66 RSYDLPITTTESELLALIDQLNADQAIDGILVQLPL--PEGIDNTKVIERIAPDKDVDGF 123
Query: 406 N 408
+
Sbjct: 124 H 124
>UniRef50_O84081 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Chlamydiaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Chlamydia trachomatis
Length = 287
Score = 43.2 bits (97), Expect = 0.002
Identities = 19/49 (38%), Positives = 30/49 (61%)
Frame = +1
Query: 262 ELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
++ A I LN ++HGI+VQ+PL +DA + ++PDK DGL+
Sbjct: 71 DILALIHQLNNDENIHGILVQLPLPK--HLDAQAILSTITPDKDVDGLH 117
>UniRef50_Q9A8Y0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=82; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Caulobacter crescentus (Caulobacter
vibrioides)
Length = 297
Score = 43.2 bits (97), Expect = 0.002
Identities = 23/59 (38%), Positives = 32/59 (54%)
Frame = +1
Query: 229 TYXLTKGHHEIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGL 405
T+ L + + EL A + LN P +HG++VQ P+ I V A+SPDK DGL
Sbjct: 68 THRLPETTTQDELLAVVAKLNADPKIHGVLVQFPVPP--HISQMDVVAALSPDKDVDGL 124
Score = 33.9 bits (74), Expect = 1.3
Identities = 22/70 (31%), Positives = 33/70 (47%)
Frame = +2
Query: 35 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLXXXXXX 214
A++I G A + + ++V L+++ G P LA+V VG S VY+R K
Sbjct: 4 AKLIDGKAFAADLRAKIAEEVAALKAE-HGVTPGLAVVLVGEDPASQVYVRNKGEQTTAA 62
Query: 215 XXXXEHXRLP 244
E RLP
Sbjct: 63 GMYSETHRLP 72
>UniRef50_Q54VK0 Cluster: Methenyl tetrahydrofolate cyclohydrolase /
NADP-dependent methylene H4F dehydrogenase; n=1;
Dictyostelium discoideum AX4|Rep: Methenyl
tetrahydrofolate cyclohydrolase / NADP-dependent
methylene H4F dehydrogenase - Dictyostelium discoideum
AX4
Length = 440
Score = 42.7 bits (96), Expect = 0.003
Identities = 23/52 (44%), Positives = 31/52 (59%)
Frame = +1
Query: 256 EIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLNT 411
E +L KI +E PSVHGIIVQ+PL + DA + ++ P K DGL +
Sbjct: 159 EDQLIKKIKYHSEDPSVHGIIVQLPLPDNLNKDA--IIQSIDPKKDVDGLTS 208
>UniRef50_Q7MVE9 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=52; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Porphyromonas gingivalis (Bacteroides gingivalis)
Length = 296
Score = 42.3 bits (95), Expect = 0.004
Identities = 22/51 (43%), Positives = 30/51 (58%)
Frame = +1
Query: 256 EIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
E EL A + LN+ P+V G IVQ+PL ID ++ +AV P K DG +
Sbjct: 78 EEELLACVHRLNQDPTVDGFIVQLPLPK--HIDEQKIIEAVDPRKDVDGFH 126
>UniRef50_A7D6I9 Cluster: Methenyltetrahydrofolate cyclohydrolase;
n=1; Halorubrum lacusprofundi ATCC 49239|Rep:
Methenyltetrahydrofolate cyclohydrolase - Halorubrum
lacusprofundi ATCC 49239
Length = 307
Score = 41.5 bits (93), Expect = 0.006
Identities = 22/49 (44%), Positives = 29/49 (59%)
Frame = +1
Query: 262 ELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
EL I LNE VHGI+VQ+P+ DH +D RV ++P K DG +
Sbjct: 86 ELYETIDDLNEREDVHGILVQLPV-PDH-VDKRRVLRQIAPVKDVDGFH 132
>UniRef50_Q8DMU0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=90; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Synechococcus elongatus (Thermosynechococcus
elongatus)
Length = 306
Score = 41.5 bits (93), Expect = 0.006
Identities = 22/51 (43%), Positives = 30/51 (58%)
Frame = +1
Query: 256 EIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
E L AKIT LN+ V GI++Q+PL +D + A+ PDK DGL+
Sbjct: 79 EAALLAKITELNQDERVDGILLQLPLPP--HLDPRPLLYAIHPDKDVDGLH 127
Score = 37.9 bits (84), Expect = 0.080
Identities = 21/56 (37%), Positives = 30/56 (53%)
Frame = +2
Query: 26 AKMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMK 193
A A + G +A SIE L V +++W G P LA+++VG S VY+R K
Sbjct: 3 AHAATCLDGKSLAQSIERQLADHVRTFQAQW-GRSPGLAVLRVGNDPASAVYVRAK 57
>UniRef50_Q0AZF5 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Syntrophomonas wolfei subsp. wolfei str.
Goettingen|Rep: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Syntrophomonas wolfei subsp. wolfei (strain Goettingen)
Length = 277
Score = 41.5 bits (93), Expect = 0.006
Identities = 21/63 (33%), Positives = 32/63 (50%)
Frame = +1
Query: 220 RRRTYXLTKGHHEIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXD 399
+ R L + + EL AKI LN+ V GI++Q+PL + + A+ PDK D
Sbjct: 58 KSRLLHLPEDTSQQELMAKIAELNQDEQVDGILLQLPLPAALEEQTDEILAAIRPDKDVD 117
Query: 400 GLN 408
G +
Sbjct: 118 GFS 120
>UniRef50_Q86F84 Cluster: Clone ZZD1003 mRNA sequence; n=1;
Schistosoma japonicum|Rep: Clone ZZD1003 mRNA sequence -
Schistosoma japonicum (Blood fluke)
Length = 332
Score = 41.1 bits (92), Expect = 0.009
Identities = 19/45 (42%), Positives = 27/45 (60%)
Frame = +1
Query: 277 ITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLNT 411
+ LN SVHGI +Q+P DSD I+ +AV+ K +GLN+
Sbjct: 84 VYKLNADSSVHGITLQLPFDSDTNINVTNSLNAVATHKDVEGLNS 128
Score = 38.3 bits (85), Expect = 0.060
Identities = 20/71 (28%), Positives = 36/71 (50%)
Frame = +2
Query: 41 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLXXXXXXXX 220
I+ G +VA ++ + ++ V L+S + + P+L +++VG S +YI+ K
Sbjct: 6 ILYGRQVAQAVGHKIKLDVALLKSSFDVY-PKLVVIEVGELPQSKLYIKQKFKFAKKYGI 64
Query: 221 XXEHXRLPRDI 253
H RLP I
Sbjct: 65 LLSHMRLPSHI 75
>UniRef50_UPI000038C811 Cluster: COG0190:
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl
tetrahydrofolate cyclohydrolase; n=1; Nostoc punctiforme
PCC 73102|Rep: COG0190: 5,10-methylene-tetrahydrofolate
dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase -
Nostoc punctiforme PCC 73102
Length = 292
Score = 40.3 bits (90), Expect = 0.015
Identities = 22/49 (44%), Positives = 30/49 (61%)
Frame = +1
Query: 262 ELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
EL I +LN+ V GI+VQ+PL DH +DA + + PDK DGL+
Sbjct: 81 ELEKVIAALNDDERVDGILVQLPL-PDH-LDAVALLHQIDPDKDADGLH 127
>UniRef50_Q9ZD32 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Rickettsia|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rickettsia prowazekii
Length = 286
Score = 40.3 bits (90), Expect = 0.015
Identities = 21/49 (42%), Positives = 28/49 (57%)
Frame = +1
Query: 262 ELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
+L KI LN + GIIVQ+PL S ID +++ AV P K DG +
Sbjct: 78 DLILKINELNLDKGISGIIVQLPLPSS--IDENKILSAVLPSKDSDGFH 124
Score = 32.3 bits (70), Expect = 4.0
Identities = 18/52 (34%), Positives = 29/52 (55%)
Frame = +2
Query: 41 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKL 196
II G +A I DL+ ++ + K + P+LAIV VG S +Y++ K+
Sbjct: 5 IIDGKALANEILADLKLEIQGFKEK-TKTSPKLAIVLVGDNPASMIYVKNKI 55
>UniRef50_Q3YRE3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Proteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Ehrlichia canis (strain Jake)
Length = 300
Score = 39.9 bits (89), Expect = 0.020
Identities = 22/63 (34%), Positives = 31/63 (49%)
Frame = +1
Query: 220 RRRTYXLTKGHHEIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXD 399
R T L E L KI LN +VHGI+VQ+P+ ID + + + + P K D
Sbjct: 64 RSETILLPSTTSESSLIDKIHELNNDDNVHGILVQLPVPK--HIDKNLIINTIDPRKDVD 121
Query: 400 GLN 408
G +
Sbjct: 122 GFH 124
>UniRef50_Q6ALZ5 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=27; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Desulfotalea psychrophila
Length = 296
Score = 39.9 bits (89), Expect = 0.020
Identities = 19/51 (37%), Positives = 27/51 (52%)
Frame = +1
Query: 256 EIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
E EL A I N S+HG++VQ+PL I+ + A+ PDK D +
Sbjct: 76 EAELLALIEKYNNDDSIHGVLVQLPLPK--HINEQNIITAIDPDKDVDAFH 124
>UniRef50_Q0SFQ8 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Actinomycetales|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rhodococcus sp. (strain RHA1)
Length = 297
Score = 39.9 bits (89), Expect = 0.020
Identities = 19/49 (38%), Positives = 28/49 (57%)
Frame = +1
Query: 262 ELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
++ + + L P VHGII+Q PL +DA R +A++P K DG N
Sbjct: 76 QIRSTLVELGHDPDVHGIILQTPLPDGTDLDALR--EAINPAKDVDGAN 122
>UniRef50_Q6F9E6 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Proteobacteria|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Acinetobacter sp. (strain ADP1)
Length = 297
Score = 39.9 bits (89), Expect = 0.020
Identities = 21/52 (40%), Positives = 29/52 (55%)
Frame = +1
Query: 256 EIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLNT 411
E EL +I LN VHGI+VQ+PL I+ RV + + P K DG ++
Sbjct: 83 EDELLTQIDRLNTERGVHGILVQLPLPKQ--INETRVLERIHPQKDVDGFHS 132
Score = 36.7 bits (81), Expect = 0.18
Identities = 20/53 (37%), Positives = 33/53 (62%)
Frame = +2
Query: 38 QIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKL 196
+II G +A S+ +++ +V R +++ G EP LA+V VG S VY+R K+
Sbjct: 12 KIIDGKAIAQSVLEEVKLEVERYKAQ--GIEPCLAVVLVGEDPASQVYVRNKV 62
>UniRef50_Q16F77 Cluster: Methylenetetrahydrofolate dehydrogenase;
n=4; cellular organisms|Rep: Methylenetetrahydrofolate
dehydrogenase - Aedes aegypti (Yellowfever mosquito)
Length = 337
Score = 39.5 bits (88), Expect = 0.026
Identities = 21/51 (41%), Positives = 31/51 (60%)
Frame = +1
Query: 256 EIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
E +L +I LN+ SV GI+VQ+P+ I+ +V ++VS DK DG N
Sbjct: 107 EEQLLKRIEELNQDDSVDGILVQLPVPG--HINERKVCNSVSCDKDVDGFN 155
Score = 36.3 bits (80), Expect = 0.24
Identities = 16/56 (28%), Positives = 29/56 (51%)
Frame = +2
Query: 29 KMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKL 196
+MA++I G ++A I +LR+Q+ + P L + +G SN Y+ K+
Sbjct: 31 EMAKLIDGKQIAADIRMELREQIEEWMKQGGNRAPHLTAILIGEDPASNTYVSNKM 86
>UniRef50_A7DNA7 Cluster: Methylenetetrahydrofolate dehydrogenase
(NADP(+)); n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Methylenetetrahydrofolate dehydrogenase
(NADP(+)) - Candidatus Nitrosopumilus maritimus SCM1
Length = 287
Score = 39.5 bits (88), Expect = 0.026
Identities = 21/50 (42%), Positives = 28/50 (56%)
Frame = +1
Query: 256 EIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGL 405
+ +L I +LN SVHGI+VQ+PL +D T +SP K DGL
Sbjct: 75 QAQLNEIIENLNNDNSVHGILVQLPLPEQ--LDEFTTTSRISPLKDVDGL 122
>UniRef50_P47259 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Mycoplasma|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma genitalium
Length = 273
Score = 39.5 bits (88), Expect = 0.026
Identities = 22/52 (42%), Positives = 33/52 (63%)
Frame = +1
Query: 256 EIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLNT 411
+ EL KI SLN +V GII+Q+P+ H +D + + +A++P K DGL T
Sbjct: 66 QAELIEKIISLNHDVNVTGIILQLPV-YPH-LDKNSLLEAINPLKDVDGLTT 115
>UniRef50_Q8EQ43 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=45; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Oceanobacillus iheyensis
Length = 285
Score = 39.1 bits (87), Expect = 0.034
Identities = 20/49 (40%), Positives = 27/49 (55%)
Frame = +1
Query: 262 ELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
EL I N SVHGI+VQ+PL +D ++ A+SP K DG +
Sbjct: 76 ELLQIIDEQNNDDSVHGILVQLPLPDQ--MDEQKIIHAISPAKDVDGFH 122
>UniRef50_Q5FJG5 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Firmicutes|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Lactobacillus acidophilus
Length = 283
Score = 39.1 bits (87), Expect = 0.034
Identities = 17/43 (39%), Positives = 27/43 (62%)
Frame = +1
Query: 277 ITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGL 405
I LNE P ++G++VQ+P + IDA + + + P+K DGL
Sbjct: 81 IDKLNEDPDINGVMVQLP--APEQIDADELLERIDPNKDVDGL 121
Score = 32.7 bits (71), Expect = 3.0
Identities = 18/73 (24%), Positives = 33/73 (45%)
Frame = +2
Query: 32 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLXXXXX 211
M +I+ G VA + L+++V L+ + G P ++ +G S +Y+R K
Sbjct: 1 MGKILDGKFVANLLGEKLKEKVKDLKEE--GITPHFCVINIGDDPASKIYVRTKKRRAEK 58
Query: 212 XXXXXEHXRLPRD 250
+ +LP D
Sbjct: 59 MGIIQDIYQLPAD 71
>UniRef50_Q4S6Y9 Cluster: Chromosome 14 SCAF14723, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 14 SCAF14723, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 1066
Score = 38.7 bits (86), Expect = 0.046
Identities = 21/57 (36%), Positives = 31/57 (54%)
Frame = +1
Query: 238 LTKGHHEIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
L K EIE+ ++ L+E P VHG+ + +P S RV A+ P+K DGL+
Sbjct: 56 LAKECSEIEIVTEVLKLSEDPGVHGLYLHLPQAS----LTSRVLTALKPEKDVDGLS 108
>UniRef50_A1HML1 Cluster: Methenyltetrahydrofolate cyclohydrolase;
n=1; Thermosinus carboxydivorans Nor1|Rep:
Methenyltetrahydrofolate cyclohydrolase - Thermosinus
carboxydivorans Nor1
Length = 279
Score = 38.7 bits (86), Expect = 0.046
Identities = 21/51 (41%), Positives = 28/51 (54%)
Frame = +1
Query: 256 EIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
E E+ A + LNE +HGI+ MPL D RV A++PDK D L+
Sbjct: 74 EEEVLALVCELNEDDHIHGILPMMPLPPHLATD--RVAAALAPDKDVDALH 122
>UniRef50_Q9KQQ6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=44; Gammaproteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Vibrio cholerae
Length = 286
Score = 38.7 bits (86), Expect = 0.046
Identities = 18/61 (29%), Positives = 34/61 (55%)
Frame = +1
Query: 226 RTYXLTKGHHEIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGL 405
+++ L E L + + LN P + GI+VQ+PL + +D +V +++ P+K DG
Sbjct: 66 KSFDLPATASEEALLSLVEELNNDPQIDGILVQLPLPA--GMDTTKVLESIHPEKDVDGF 123
Query: 406 N 408
+
Sbjct: 124 H 124
>UniRef50_Q4FNW1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Pelagibacter ubique
Length = 281
Score = 38.7 bits (86), Expect = 0.046
Identities = 17/51 (33%), Positives = 30/51 (58%)
Frame = +2
Query: 41 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMK 193
+I G ++A + LRQ+V L++K + P L ++ +G S +Y+RMK
Sbjct: 3 LIDGKKIAAELREQLRQEVVELKAKHNKI-PGLTVILIGEMAPSQIYVRMK 52
Score = 37.1 bits (82), Expect = 0.14
Identities = 18/45 (40%), Positives = 26/45 (57%)
Frame = +1
Query: 274 KITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
KI LN+ S+ GI+VQ+PL ID +V + + P K DG +
Sbjct: 80 KIEELNKDESISGILVQLPLPK--HIDKQKVIETILPGKDVDGFH 122
>UniRef50_UPI00015B49ED Cluster: PREDICTED: similar to putative
glyoxylate reductase/hydroxypyruvate reductase; n=1;
Nasonia vitripennis|Rep: PREDICTED: similar to putative
glyoxylate reductase/hydroxypyruvate reductase - Nasonia
vitripennis
Length = 699
Score = 38.3 bits (85), Expect = 0.060
Identities = 19/49 (38%), Positives = 30/49 (61%)
Frame = +1
Query: 262 ELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
EL ++ LN+ P+V G++VQ+P+ +H I V AV+P K DG +
Sbjct: 103 ELLHEVQKLNDDPTVDGLLVQLPV-PEH-ISEREVCQAVTPTKDVDGFH 149
>UniRef50_A4EAK0 Cluster: Putative uncharacterized protein; n=3;
Bacteria|Rep: Putative uncharacterized protein -
Collinsella aerofaciens ATCC 25986
Length = 284
Score = 38.3 bits (85), Expect = 0.060
Identities = 25/74 (33%), Positives = 35/74 (47%)
Frame = +2
Query: 32 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLXXXXX 211
MA+++ G VA ++ +L + LR + G P LAIV+VG RED Y R L
Sbjct: 1 MAELLKGAPVARALTEELAARCAALREQ--GVVPMLAIVRVGEREDDLSYERGALKRCEK 58
Query: 212 XXXXXEHXRLPRDI 253
LP D+
Sbjct: 59 VGIEARRVLLPVDV 72
Score = 32.3 bits (70), Expect = 4.0
Identities = 17/48 (35%), Positives = 25/48 (52%)
Frame = +1
Query: 262 ELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGL 405
EL A I +N P+VHG ++ PL + +D V A+ P K D +
Sbjct: 76 ELLAAIKDINADPAVHGCLMFRPLPA--GLDEDAVAAALDPAKDVDSM 121
>UniRef50_Q2UUX1 Cluster: RIB40 genomic DNA, SC009; n=1; Aspergillus
oryzae|Rep: RIB40 genomic DNA, SC009 - Aspergillus
oryzae
Length = 275
Score = 38.3 bits (85), Expect = 0.060
Identities = 24/71 (33%), Positives = 35/71 (49%), Gaps = 5/71 (7%)
Frame = +1
Query: 211 NWYRRRTYXLTKGHHEIELXAK-----ITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDA 375
NW R+ + H ++L K I ++N + SVHGIIV P+ D D +
Sbjct: 51 NWTRKTCQEIGVHFHLMKLSPKNVATYIRAINANNSVHGIIVYYPIFGDRRDD--EIRQL 108
Query: 376 VSPDKXXDGLN 408
V+P K +GLN
Sbjct: 109 VAPSKDVEGLN 119
>UniRef50_A0JTZ0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=51; Actinobacteria (class)|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Arthrobacter sp. (strain FB24)
Length = 302
Score = 38.3 bits (85), Expect = 0.060
Identities = 18/51 (35%), Positives = 28/51 (54%)
Frame = +1
Query: 256 EIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
+ ++ A I LN P+ HG IVQ+PL +D + + + P K DGL+
Sbjct: 77 QAQVEALIDELNADPACHGYIVQLPLPK--HLDTDAILERIDPAKDADGLH 125
>UniRef50_Q74J95 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Lactobacillus|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Lactobacillus johnsonii
Length = 283
Score = 37.9 bits (84), Expect = 0.080
Identities = 15/52 (28%), Positives = 31/52 (59%)
Frame = +1
Query: 256 EIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLNT 411
+ E+ I N+ P++H I++Q+PL ++ + +A++P+K DG N+
Sbjct: 74 QAEVLQAIHHYNDDPTIHAILIQLPLPK--HLNQTELIEAIAPEKDVDGFNS 123
>UniRef50_Q2B9L0 Cluster: Bifunctional protein FolD; n=1; Bacillus
sp. NRRL B-14911|Rep: Bifunctional protein FolD -
Bacillus sp. NRRL B-14911
Length = 322
Score = 37.5 bits (83), Expect = 0.11
Identities = 19/50 (38%), Positives = 28/50 (56%)
Frame = +1
Query: 262 ELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLNT 411
EL I LNE+ VHGI++Q P+ ID + + +S DK DG+ +
Sbjct: 117 ELVKTIEELNENKEVHGILLQHPVPG--HIDERKAFETISIDKDVDGVTS 164
>UniRef50_Q3AYX2 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=36; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Synechococcus sp. (strain CC9902)
Length = 293
Score = 37.5 bits (83), Expect = 0.11
Identities = 19/50 (38%), Positives = 29/50 (58%)
Frame = +1
Query: 262 ELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLNT 411
E+ + I LN P V GI++Q+PL +D + A+ P+K DGL+T
Sbjct: 77 EVLSTIQQLNADPRVDGILLQLPL--PEGLDEGPLLMAIDPEKDADGLHT 124
>UniRef50_Q1II76 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Acidobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Acidobacteria bacterium (strain Ellin345)
Length = 307
Score = 37.5 bits (83), Expect = 0.11
Identities = 18/49 (36%), Positives = 29/49 (59%)
Frame = +1
Query: 262 ELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
+L + SLN + GI+VQ+PL +D+ ++ AVSP+K DG +
Sbjct: 77 DLLQLVESLNRRNDIDGILVQLPLPKQ--VDSKKILLAVSPEKDVDGFH 123
>UniRef50_A3PVV6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; Actinobacteridae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycobacterium sp. (strain JLS)
Length = 288
Score = 36.7 bits (81), Expect = 0.18
Identities = 19/51 (37%), Positives = 27/51 (52%)
Frame = +1
Query: 256 EIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
+ EL A I LN +P G IVQ+PL +D + + + P K DGL+
Sbjct: 78 QAELDATIDELNANPECTGYIVQLPLPK--HLDENAALERIDPGKDADGLH 126
>UniRef50_Q6BNW9 Cluster: Debaryomyces hansenii chromosome E of
strain CBS767 of Debaryomyces hansenii; n=2;
Debaryomyces hansenii|Rep: Debaryomyces hansenii
chromosome E of strain CBS767 of Debaryomyces hansenii -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 276
Score = 36.3 bits (80), Expect = 0.24
Identities = 14/24 (58%), Positives = 18/24 (75%)
Frame = +2
Query: 125 FEPRLAIVQVGGREDSNVYIRMKL 196
F P L I+QVGGR DS+ Y++ KL
Sbjct: 74 FRPNLTIIQVGGRPDSSAYVKAKL 97
>UniRef50_Q4FTX6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=24; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Psychrobacter arcticum
Length = 295
Score = 36.3 bits (80), Expect = 0.24
Identities = 19/48 (39%), Positives = 27/48 (56%)
Frame = +1
Query: 262 ELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGL 405
EL AKI LN +P VHGI++Q P+ + ID + + K DG+
Sbjct: 89 ELMAKIDELNNNPDVHGILLQHPVPA--HIDERACFEQIDLAKDVDGV 134
>UniRef50_A5CF58 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Orientia tsutsugamushi Boryong|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Orientia tsutsugamushi
(strain Boryong) (Rickettsia tsutsugamushi)
Length = 301
Score = 36.3 bits (80), Expect = 0.24
Identities = 22/51 (43%), Positives = 29/51 (56%)
Frame = +1
Query: 256 EIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
E +L + I LN +VHGIIVQ+PL IDA ++ + K DGLN
Sbjct: 75 EKKLFSVIDDLNCDSTVHGIIVQLPLPP--HIDALKLFARIDSRKDVDGLN 123
>UniRef50_Q8TK95 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Methanosarcina acetivorans
Length = 290
Score = 36.3 bits (80), Expect = 0.24
Identities = 20/60 (33%), Positives = 30/60 (50%), Gaps = 1/60 (1%)
Frame = +1
Query: 232 YXLTKGHHEIELXAKITSLNESPSVHGIIVQMPLDSD-HXIDAHRVTDAVSPDKXXDGLN 408
Y L + EL I SLN++ VH I++Q+PL + +A+SP K DG +
Sbjct: 73 YLLPGDATQEELLTLIDSLNKNKDVHAILLQLPLPKHFSPQETQEAMEAISPTKDADGFH 132
>UniRef50_Q97HC9 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; Clostridium|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Clostridium acetobutylicum
Length = 278
Score = 36.3 bits (80), Expect = 0.24
Identities = 21/60 (35%), Positives = 31/60 (51%)
Frame = +1
Query: 226 RTYXLTKGHHEIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGL 405
++ L + E EL I LN +HGI++Q+PL + IDA VT + +K D L
Sbjct: 65 KSIFLDESIREEELIKLIEGLNVDNKIHGIMLQLPL--PNHIDAKLVTSKIDANKDIDSL 122
>UniRef50_Q4RT28 Cluster: Chromosome 12 SCAF14999, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 12 SCAF14999, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 342
Score = 35.9 bits (79), Expect = 0.32
Identities = 21/51 (41%), Positives = 29/51 (56%)
Frame = +1
Query: 256 EIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
E EL I LN V G++VQ+PL +H ID + +AV+P K DG +
Sbjct: 103 EEELLDLIDKLNTDHRVDGLLVQLPLP-EH-IDERTICNAVAPTKDVDGFH 151
>UniRef50_Q5SJ94 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermus thermophilus|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermus thermophilus (strain HB8 / ATCC
27634 / DSM 579)
Length = 282
Score = 35.5 bits (78), Expect = 0.42
Identities = 22/64 (34%), Positives = 31/64 (48%)
Frame = +1
Query: 217 YRRRTYXLTKGHHEIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXX 396
YR + + E L +I +LN V GI+VQ+PL I RV +A+ P K
Sbjct: 59 YRSQVEVYPEDLPEEALLERIAALNADEEVDGILVQLPLPP--HIRTQRVLEAIHPLKDV 116
Query: 397 DGLN 408
DG +
Sbjct: 117 DGFH 120
Score = 32.7 bits (71), Expect = 3.0
Identities = 19/53 (35%), Positives = 31/53 (58%)
Frame = +2
Query: 35 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMK 193
AQ++SG E A ++ ++R RLRS F P L ++++G S Y+R+K
Sbjct: 3 AQVLSGHEAAEAVYEEIR---ARLRSL--SFTPSLRVIRLGEDPASVAYVRLK 50
>UniRef50_Q8RAD0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Thermoanaerobacter|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermoanaerobacter tengcongensis
Length = 280
Score = 35.1 bits (77), Expect = 0.56
Identities = 17/52 (32%), Positives = 30/52 (57%)
Frame = +2
Query: 41 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKL 196
II G E++ I+ ++++++ G++PRLAI+ G E S VY K+
Sbjct: 5 IIDGKEISNRIKEEVKREIQEF-----GYKPRLAILMAGDDESSKVYANSKV 51
Score = 33.9 bits (74), Expect = 1.3
Identities = 15/41 (36%), Positives = 23/41 (56%)
Frame = +1
Query: 277 ITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXD 399
+ LNE HGI+++MPL +D +V D ++P K D
Sbjct: 78 LEKLNEDKDTHGIMIEMPLPKGFDVD--KVYDTINPYKDVD 116
>UniRef50_P56467 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Helicobacter pylori (Campylobacter pylori)
Length = 290
Score = 35.1 bits (77), Expect = 0.56
Identities = 16/51 (31%), Positives = 28/51 (54%)
Frame = +1
Query: 256 EIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
E +L + I N ++ G++VQ+PL ID + +A+ P+K DG +
Sbjct: 79 EAKLLSLIKDYNTDQNISGVLVQLPLP--RHIDTKMILEAIDPNKDVDGFH 127
Score = 31.1 bits (67), Expect = 9.1
Identities = 15/52 (28%), Positives = 31/52 (59%)
Frame = +2
Query: 41 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKL 196
++ G +A +IE DL+ ++ + ++ + P+LA++ VG S Y+ MK+
Sbjct: 8 LLDGQALADNIEKDLKHKIQIITAQ-THKRPKLAVILVGKDPASITYVNMKI 58
>UniRef50_Q9HPY4 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Halobacterium salinarium (Halobacterium
halobium)
Length = 297
Score = 34.7 bits (76), Expect = 0.74
Identities = 20/44 (45%), Positives = 23/44 (52%)
Frame = +1
Query: 277 ITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
+ LN VHGI+VQ P DH D RV AV P K DG +
Sbjct: 81 VAELNAREDVHGILVQDP-TPDHVPD-ERVLSAVDPAKDVDGFH 122
>UniRef50_Q6F1V0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Mollicutes|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mesoplasma florum (Acholeplasma florum)
Length = 286
Score = 34.3 bits (75), Expect = 0.98
Identities = 17/49 (34%), Positives = 27/49 (55%)
Frame = +1
Query: 262 ELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
EL KI LN ++ GI++Q+PL D + + A++P K DG +
Sbjct: 76 ELYNKINELNNDQNIDGILLQLPLPIDFIEEDY--LQAITPSKDVDGFH 122
Score = 33.1 bits (72), Expect = 2.3
Identities = 19/73 (26%), Positives = 35/73 (47%)
Frame = +2
Query: 41 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLXXXXXXXX 220
I+ G +VA + +L ++++ +K +P+L ++ VG S VY+ K+
Sbjct: 3 ILDGKKVASRRKEELTAKISKYHNKGLR-KPKLVVIMVGNDPASEVYVSHKIKVANEVGI 61
Query: 221 XXEHXRLPRDIMK 259
E R +DI K
Sbjct: 62 YSELLRFDKDIKK 74
>UniRef50_Q057D7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Enterobacteriaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Buchnera aphidicola subsp. Cinara cedri
Length = 284
Score = 33.9 bits (74), Expect = 1.3
Identities = 18/59 (30%), Positives = 32/59 (54%)
Frame = +1
Query: 232 YXLTKGHHEIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
+ L+ EIEL I LN++ + GI++Q+PL I+ ++ ++ P K DG +
Sbjct: 68 WHLSNQIEEIELINLIKKLNKNKCIDGILIQLPLPI--KINYLKIITSIDPKKDVDGFH 124
>UniRef50_Q6MI74 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Bdellovibrio bacteriovorus|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Bdellovibrio
bacteriovorus
Length = 288
Score = 33.1 bits (72), Expect = 2.3
Identities = 18/54 (33%), Positives = 31/54 (57%)
Frame = +2
Query: 32 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMK 193
M I+ G EVA + L +V + + + G P+L++V VG + S+VY++ K
Sbjct: 1 MVLILDGKEVAKEVRASLVPRVAKFKETY-GRAPQLSVVIVGDDKASHVYVKNK 53
>UniRef50_UPI0000DB7ABF Cluster: PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor; n=1; Apis mellifera|Rep:
PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor - Apis mellifera
Length = 407
Score = 32.7 bits (71), Expect = 3.0
Identities = 18/60 (30%), Positives = 32/60 (53%)
Frame = +1
Query: 229 TYXLTKGHHEIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
T L + + ++ +I +LN+ +V GI+VQ+PL ++ V A+ P K DG +
Sbjct: 174 TIHLDEKSSQQDIINEIDNLNKDKTVDGILVQLPLIK--HMNEQEVCQAIIPSKDVDGFH 231
>UniRef50_Q1NQA0 Cluster: 4-diphosphocytidyl-2C-methyl-D-erythritol
kinase; n=1; delta proteobacterium MLMS-1|Rep:
4-diphosphocytidyl-2C-methyl-D-erythritol kinase - delta
proteobacterium MLMS-1
Length = 297
Score = 32.3 bits (70), Expect = 4.0
Identities = 21/60 (35%), Positives = 32/60 (53%), Gaps = 1/60 (1%)
Frame = -1
Query: 274 LLXALFHDVPW*AXMFGGDTNFXSCLQLHPDVDVGVLAPAHLHDGKPGLEAR-PF*TQPR 98
L +L+ +P A + GG ++ + L+ + GVL+PA LH GL A PF QP+
Sbjct: 93 LAISLYKKIPTAAGLGGGSSDAAAVLRGLQGLHPGVLSPAQLHQLARGLGADVPFFLQPQ 152
>UniRef50_Q7TU81 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Prochlorococcus marinus|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Prochlorococcus marinus subsp. pastoris
(strain CCMP 1378 / MED4)
Length = 298
Score = 32.3 bits (70), Expect = 4.0
Identities = 14/49 (28%), Positives = 27/49 (55%)
Frame = +1
Query: 262 ELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
E+ + LN ++ G+++Q+P+ D R+ ++P+K DGLN
Sbjct: 77 EVEQLLNKLNLDNNIDGMLLQLPISKK--FDEQRLISFINPEKDVDGLN 123
>UniRef50_Q3A1Q7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Pelobacter carbinolicus (strain DSM 2380 / Gra Bd 1)
Length = 290
Score = 32.3 bits (70), Expect = 4.0
Identities = 16/49 (32%), Positives = 25/49 (51%)
Frame = +1
Query: 262 ELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLN 408
+L A + N+SP V I+Q PL D + + + P+K DGL+
Sbjct: 77 DLLAAVRDFNDSPDVDAYIIQYPLPK--GFDFNEALNLMLPEKDADGLH 123
>UniRef50_Q54Z91 Cluster: Methylenetetrahydrofolate dehydrogenase;
n=2; Dictyostelium discoideum|Rep:
Methylenetetrahydrofolate dehydrogenase - Dictyostelium
discoideum AX4
Length = 313
Score = 31.9 bits (69), Expect = 5.2
Identities = 19/58 (32%), Positives = 30/58 (51%)
Frame = +1
Query: 238 LTKGHHEIELXAKITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGLNT 411
+ K ++L I N VHGI+V P+ +D++ + D VSP K +GL+T
Sbjct: 71 ILKRVERVDLEDLIIEANNDSCVHGILVYYPVFGG-MMDSY-LQDVVSPTKDIEGLST 126
>UniRef50_Q4A6B1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma synoviae 53|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Mycoplasma synoviae (strain 53)
Length = 278
Score = 31.9 bits (69), Expect = 5.2
Identities = 21/53 (39%), Positives = 29/53 (54%)
Frame = +2
Query: 38 QIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKL 196
+I+SG E A E DL+Q L +LAI+QVG + +SN Y+ KL
Sbjct: 2 KILSGREKA---EQDLKQLKKELDELNLNRPIKLAIIQVGDKMESNRYVEQKL 51
>UniRef50_A3M3Q9 Cluster: Putative flavin-binding monooxygenase;
n=1; Acinetobacter baumannii ATCC 17978|Rep: Putative
flavin-binding monooxygenase - Acinetobacter baumannii
(strain ATCC 17978 / NCDC KC 755)
Length = 433
Score = 31.5 bits (68), Expect = 6.9
Identities = 16/26 (61%), Positives = 16/26 (61%)
Frame = +1
Query: 238 LTKGHHEIELXAKITSLNESPSVHGI 315
L GHHEI L A TSLNE P V I
Sbjct: 180 LQYGHHEIRLLAFTTSLNEMPLVEYI 205
>UniRef50_Q016N9 Cluster: 5'-3' exoribonuclease 1; n=2;
Ostreococcus|Rep: 5'-3' exoribonuclease 1 - Ostreococcus
tauri
Length = 1418
Score = 31.5 bits (68), Expect = 6.9
Identities = 16/41 (39%), Positives = 25/41 (60%)
Frame = +2
Query: 11 ETVLWAKMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEP 133
E LWAK+ I+SG EV G E+ + + + R++ G+EP
Sbjct: 230 EDPLWAKVTVILSGHEVRGEGEHKIMEHIRWARTQ-PGWEP 269
>UniRef50_Q979W3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermoplasma|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermoplasma volcanium
Length = 281
Score = 31.5 bits (68), Expect = 6.9
Identities = 14/53 (26%), Positives = 30/53 (56%)
Frame = +2
Query: 38 QIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKL 196
+++ G E+A +L++++ ++ G PRL ++QVG + +Y R K+
Sbjct: 4 KLLKGEEIAEKKAEELKERIEKM-----GVSPRLVLLQVGNYSAATIYARAKI 51
>UniRef50_Q14NV1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Spiroplasma citri|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Spiroplasma citri
Length = 286
Score = 31.5 bits (68), Expect = 6.9
Identities = 16/52 (30%), Positives = 30/52 (57%)
Frame = +2
Query: 38 QIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMK 193
+II G V+ I+ + +Q+ ++++K P L I+Q+G + S YI+ K
Sbjct: 5 KIIDGKMVSELIKAKITEQILKIKAKKQRV-PALTIIQIGNNKASTTYIKNK 55
>UniRef50_Q8ZZK1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Pyrobaculum|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Pyrobaculum aerophilum
Length = 311
Score = 31.5 bits (68), Expect = 6.9
Identities = 17/43 (39%), Positives = 23/43 (53%)
Frame = +1
Query: 277 ITSLNESPSVHGIIVQMPLDSDHXIDAHRVTDAVSPDKXXDGL 405
I SLN V G+I+Q PL +D + A+SP+K D L
Sbjct: 88 IESLNRRDDVTGVIIQKPLPP--FVDEKALFSALSPEKDVDAL 128
>UniRef50_UPI0000585CF2 Cluster: PREDICTED: similar to beta
spectrin; n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to beta spectrin - Strongylocentrotus
purpuratus
Length = 200
Score = 31.1 bits (67), Expect = 9.1
Identities = 14/43 (32%), Positives = 24/43 (55%)
Frame = +2
Query: 8 NETVLWAKMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPR 136
+E +L K S + V G ND+ ++ RLR+ ++G +PR
Sbjct: 11 SEAILQRKHVSFQSDLPVLGQQVNDVHEEADRLRATYAGDKPR 53
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 354,245,651
Number of Sequences: 1657284
Number of extensions: 5860557
Number of successful extensions: 12514
Number of sequences better than 10.0: 76
Number of HSP's better than 10.0 without gapping: 12275
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 12491
length of database: 575,637,011
effective HSP length: 92
effective length of database: 423,166,883
effective search space used: 18619342852
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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