Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fbS20034
(519 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q9XYB0 Cluster: PugilistDominant; n=2; Coelomata|Rep: P... 126 2e-28
UniRef50_UPI00015B59A5 Cluster: PREDICTED: similar to ENSANGP000... 124 1e-27
UniRef50_Q4T2B9 Cluster: Chromosome undetermined SCAF10300, whol... 100 2e-20
UniRef50_P11586 Cluster: C-1-tetrahydrofolate synthase, cytoplas... 99 3e-20
UniRef50_O84081 Cluster: Bifunctional protein folD [Includes: Me... 81 2e-14
UniRef50_Q24UZ7 Cluster: Bifunctional protein folD 2 [Includes: ... 81 2e-14
UniRef50_Q9LHH7 Cluster: 5,10-methylenetetrahydrofolate dehydrog... 77 2e-13
UniRef50_Q5IWX9 Cluster: Plastid 5,10-methylene-tetrahydrofolate... 77 2e-13
UniRef50_Q83FS2 Cluster: Bifunctional protein folD [Includes: Me... 76 4e-13
UniRef50_Q5PBL6 Cluster: Bifunctional protein folD [Includes: Me... 76 4e-13
UniRef50_O65271 Cluster: F6N23.26 protein; n=20; Viridiplantae|R... 76 6e-13
UniRef50_O65269 Cluster: F6N23.28 protein; n=1; Arabidopsis thal... 73 4e-12
UniRef50_O83714 Cluster: Bifunctional protein folD [Includes: Me... 73 5e-12
UniRef50_A1AL91 Cluster: Bifunctional protein folD [Includes: Me... 73 5e-12
UniRef50_Q6ALZ5 Cluster: Bifunctional protein folD [Includes: Me... 73 5e-12
UniRef50_Q21285 Cluster: Dauer or aging adult overexpression pro... 71 1e-11
UniRef50_Q54VK0 Cluster: Methenyl tetrahydrofolate cyclohydrolas... 71 2e-11
UniRef50_P13995 Cluster: Bifunctional methylenetetrahydrofolate ... 71 2e-11
UniRef50_Q8KN38 Cluster: Bifunctional protein folD [Includes: Me... 70 3e-11
UniRef50_Q9A8Y0 Cluster: Bifunctional protein folD [Includes: Me... 70 3e-11
UniRef50_Q16F77 Cluster: Methylenetetrahydrofolate dehydrogenase... 70 4e-11
UniRef50_Q7MVE9 Cluster: Bifunctional protein folD [Includes: Me... 70 4e-11
UniRef50_Q0AZF5 Cluster: Bifunctional protein folD 1 [Includes: ... 70 4e-11
UniRef50_Q63SL6 Cluster: Bifunctional protein folD [Includes: Me... 69 9e-11
UniRef50_A0JTZ0 Cluster: Bifunctional protein folD [Includes: Me... 69 9e-11
UniRef50_Q8TK95 Cluster: Bifunctional protein folD [Includes: Me... 68 1e-10
UniRef50_Q8DMU0 Cluster: Bifunctional protein folD [Includes: Me... 68 1e-10
UniRef50_Q1II76 Cluster: Bifunctional protein folD [Includes: Me... 68 1e-10
UniRef50_Q5SJ94 Cluster: Bifunctional protein folD [Includes: Me... 66 3e-10
UniRef50_A5CF58 Cluster: Bifunctional protein folD [Includes: Me... 66 3e-10
UniRef50_Q8EQ43 Cluster: Bifunctional protein folD [Includes: Me... 66 3e-10
UniRef50_Q9ZD32 Cluster: Bifunctional protein folD [Includes: Me... 66 5e-10
UniRef50_Q4RT28 Cluster: Chromosome 12 SCAF14999, whole genome s... 64 2e-09
UniRef50_Q4FNW1 Cluster: Bifunctional protein folD [Includes: Me... 64 2e-09
UniRef50_Q3YRE3 Cluster: Bifunctional protein folD [Includes: Me... 64 2e-09
UniRef50_Q6BNW9 Cluster: Debaryomyces hansenii chromosome E of s... 63 4e-09
UniRef50_Q8RAD0 Cluster: Bifunctional protein folD [Includes: Me... 62 6e-09
UniRef50_Q3AYX2 Cluster: Bifunctional protein folD [Includes: Me... 62 6e-09
UniRef50_A1HML1 Cluster: Methenyltetrahydrofolate cyclohydrolase... 62 7e-09
UniRef50_Q97HC9 Cluster: Bifunctional protein folD [Includes: Me... 62 1e-08
UniRef50_A7D6I9 Cluster: Methenyltetrahydrofolate cyclohydrolase... 61 2e-08
UniRef50_Q4S6Y9 Cluster: Chromosome 14 SCAF14723, whole genome s... 60 2e-08
UniRef50_UPI000038C811 Cluster: COG0190: 5,10-methylene-tetrahyd... 60 3e-08
UniRef50_Q3A1Q7 Cluster: Bifunctional protein folD [Includes: Me... 60 4e-08
UniRef50_Q6F1V0 Cluster: Bifunctional protein folD [Includes: Me... 59 7e-08
UniRef50_UPI00015B49ED Cluster: PREDICTED: similar to putative g... 58 9e-08
UniRef50_O51057 Cluster: Bifunctional protein folD [Includes: Me... 58 9e-08
UniRef50_UPI000065DF90 Cluster: methylenetetrahydrofolate dehydr... 58 1e-07
UniRef50_A7DNA7 Cluster: Methylenetetrahydrofolate dehydrogenase... 58 1e-07
UniRef50_Q9HPY4 Cluster: Bifunctional protein folD [Includes: Me... 58 1e-07
UniRef50_Q74GN1 Cluster: Bifunctional protein folD 1 [Includes: ... 58 1e-07
UniRef50_Q6F9E6 Cluster: Bifunctional protein folD 1 [Includes: ... 58 1e-07
UniRef50_Q9KQQ6 Cluster: Bifunctional protein folD [Includes: Me... 58 2e-07
UniRef50_A3PVV6 Cluster: Bifunctional protein folD [Includes: Me... 58 2e-07
UniRef50_Q8ZZK1 Cluster: Bifunctional protein folD [Includes: Me... 55 8e-07
UniRef50_A4EAK0 Cluster: Putative uncharacterized protein; n=3; ... 55 1e-06
UniRef50_Q86F84 Cluster: Clone ZZD1003 mRNA sequence; n=1; Schis... 54 3e-06
UniRef50_P56467 Cluster: Bifunctional protein folD [Includes: Me... 54 3e-06
UniRef50_A5V1H2 Cluster: Methylenetetrahydrofolate dehydrogenase... 53 5e-06
UniRef50_Q4FTX6 Cluster: Bifunctional protein folD [Includes: Me... 53 5e-06
UniRef50_Q7TU81 Cluster: Bifunctional protein folD [Includes: Me... 53 5e-06
UniRef50_Q987T6 Cluster: Bifunctional protein folD 2 [Includes: ... 52 6e-06
UniRef50_Q6D2E6 Cluster: Bifunctional protein folD [Includes: Me... 52 8e-06
UniRef50_Q5FJG5 Cluster: Bifunctional protein folD [Includes: Me... 52 1e-05
UniRef50_Q189R8 Cluster: Bifunctional protein folD [Includes: Me... 52 1e-05
UniRef50_Q0SFQ8 Cluster: Bifunctional protein folD 1 [Includes: ... 51 1e-05
UniRef50_Q5RGD2 Cluster: Novel protein similar to vertebrate for... 51 2e-05
UniRef50_Q2B9L0 Cluster: Bifunctional protein FolD; n=1; Bacillu... 50 2e-05
UniRef50_Q0AWX5 Cluster: Bifunctional protein folD 2 [Includes: ... 50 3e-05
UniRef50_UPI0000DB7ABF Cluster: PREDICTED: similar to Bifunction... 50 4e-05
UniRef50_Q2JCX4 Cluster: Bifunctional protein folD 1 [Includes: ... 50 4e-05
UniRef50_Q8W528 Cluster: Methylenetetrahydrofolate dehydrogenase... 49 6e-05
UniRef50_Q04FB7 Cluster: Bifunctional protein folD [Includes: Me... 48 1e-04
UniRef50_Q4A6B1 Cluster: Bifunctional protein folD [Includes: Me... 48 2e-04
UniRef50_Q74J95 Cluster: Bifunctional protein folD 1 [Includes: ... 48 2e-04
UniRef50_UPI00006CB712 Cluster: tetrahydrofolate dehydrogenase/c... 46 4e-04
UniRef50_Q8EV80 Cluster: Bifunctional protein folD [Includes: Me... 46 4e-04
UniRef50_Q8RDM4 Cluster: Bifunctional protein folD [Includes: Me... 46 4e-04
UniRef50_Q6MI74 Cluster: Bifunctional protein folD [Includes: Me... 46 5e-04
UniRef50_UPI00006CCCC6 Cluster: methylenetetrahydrofolate dehydr... 46 7e-04
UniRef50_A5IXS7 Cluster: FolD bifunctional protein; n=1; Mycopla... 45 0.001
UniRef50_Q14NV1 Cluster: Bifunctional protein folD [Includes: Me... 45 0.001
UniRef50_Q2UUX1 Cluster: RIB40 genomic DNA, SC009; n=1; Aspergil... 44 0.003
UniRef50_A0DMT9 Cluster: Chromosome undetermined scaffold_57, wh... 43 0.004
UniRef50_A0C3Q0 Cluster: Chromosome undetermined scaffold_147, w... 42 0.006
UniRef50_P47259 Cluster: Bifunctional protein folD [Includes: Me... 42 0.008
UniRef50_Q54Z91 Cluster: Methylenetetrahydrofolate dehydrogenase... 40 0.026
UniRef50_Q6KID0 Cluster: Bifunctional protein folD [Includes: Me... 40 0.026
UniRef50_Q979W3 Cluster: Bifunctional protein folD [Includes: Me... 39 0.060
UniRef50_Q057D7 Cluster: Bifunctional protein folD [Includes: Me... 39 0.060
UniRef50_Q8KEH0 Cluster: Methylenetetrahydrofolate dehydrogenase... 37 0.24
UniRef50_Q4VDG8 Cluster: Putative methylene tetrahydrofolate deh... 37 0.32
UniRef50_A7AXK7 Cluster: Putative uncharacterized protein; n=1; ... 36 0.42
UniRef50_UPI0000D9D4E1 Cluster: PREDICTED: similar to Bifunction... 35 0.97
UniRef50_A6NP56 Cluster: Uncharacterized protein ENSP00000372121... 35 0.97
UniRef50_Q9X288 Cluster: Bifunctional protein folD [Includes: Me... 35 1.3
UniRef50_Q9RW02 Cluster: Bifunctional protein folD [Includes: Me... 35 1.3
UniRef50_A6FY71 Cluster: Histone deacetylase superfamily protein... 33 3.9
UniRef50_Q98QV3 Cluster: Bifunctional protein folD [Includes: Me... 33 5.2
UniRef50_Q0A579 Cluster: Putative uncharacterized protein; n=1; ... 32 6.8
UniRef50_A2DM64 Cluster: Putative uncharacterized protein; n=1; ... 32 6.8
UniRef50_Q5KEZ0 Cluster: Methylenetetrahydrofolate dehydrogenase... 32 9.0
>UniRef50_Q9XYB0 Cluster: PugilistDominant; n=2; Coelomata|Rep:
PugilistDominant - Drosophila melanogaster (Fruit fly)
Length = 268
Score = 126 bits (305), Expect = 2e-28
Identities = 56/85 (65%), Positives = 68/85 (80%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+LL KI LNE P VHGIIVQMP D D+HR+TDAVSP+KDVDGL+T+NEGR+ +GD
Sbjct: 80 ELLDKINDLNEDPRVHGIIVQMPLDCDTPIDSHRITDAVSPEKDVDGLHTVNEGRLAIGD 139
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAG 508
L G +PCTP GC+ELI ++GV IAG
Sbjct: 140 LGGFLPCTPWGCLELIRRSGVEIAG 164
Score = 93.5 bits (222), Expect = 3e-18
Identities = 46/76 (60%), Positives = 57/76 (75%)
Frame = +3
Query: 27 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
A+IISG VA SI +LR +VT + + + F P L IVQVGGR DSNVYIRMK+KAA +I
Sbjct: 4 AKIISGTAVAKSIREELRNEVTAMSKQLADFVPGLRIVQVGGREDSNVYIRMKIKAATEI 63
Query: 207 GIAAEHIRLPRDITEI 254
GI A H++LPR ITE+
Sbjct: 64 GIDAAHVQLPRSITEV 79
>UniRef50_UPI00015B59A5 Cluster: PREDICTED: similar to
ENSANGP00000016878; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000016878 - Nasonia
vitripennis
Length = 866
Score = 124 bits (299), Expect = 1e-27
Identities = 54/86 (62%), Positives = 67/86 (77%)
Frame = +2
Query: 251 NKLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVG 430
++LL K+ LN P HGIIVQMP S + ++H +TD VSPDKDVDGLNTINEGRV +G
Sbjct: 82 HELLTKLNKLNNDPDTHGIIVQMPLDSVNKINSHLITDTVSPDKDVDGLNTINEGRVAIG 141
Query: 431 DLSGXIPCTPAGCVELIXKTGVTIAG 508
D+SG +PCTP GC+ELI ++GV IAG
Sbjct: 142 DMSGFLPCTPNGCIELIKRSGVPIAG 167
Score = 81.0 bits (191), Expect = 1e-14
Identities = 37/73 (50%), Positives = 50/73 (68%)
Frame = +3
Query: 33 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGI 212
++SG ++A I L + V ++ K + P LAIVQVGGR DSNVYIRMK+KAA +IGI
Sbjct: 9 VLSGTDLAKEIRESLAKDVAAIQQKLPNYAPGLAIVQVGGREDSNVYIRMKIKAASEIGI 68
Query: 213 AAEHIRLPRDITE 251
A H+++P TE
Sbjct: 69 KATHVKMPNTTTE 81
>UniRef50_Q4T2B9 Cluster: Chromosome undetermined SCAF10300, whole
genome shotgun sequence; n=6; Clupeocephala|Rep:
Chromosome undetermined SCAF10300, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 348
Score = 100 bits (240), Expect = 2e-20
Identities = 47/87 (54%), Positives = 63/87 (72%), Gaps = 1/87 (1%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
++L I S+NE SVHG+IVQ+P S H D+ +T+ VS DKDVDGL+ IN GR+ GD
Sbjct: 126 EVLLNILSINEDQSVHGLIVQLPLDSVHHIDSECITNTVSADKDVDGLSCINAGRLSRGD 185
Query: 434 LSG-XIPCTPAGCVELIXKTGVTIAGK 511
L +PCTP+GC+ELI +TGV++ GK
Sbjct: 186 LDACFLPCTPSGCLELIRQTGVSLEGK 212
Score = 51.6 bits (118), Expect = 1e-05
Identities = 28/59 (47%), Positives = 39/59 (66%)
Frame = +3
Query: 75 LRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRDITE 251
L Q++ RL S F + ++QVG R DSN+YI K+KAA +IGI A+H+RLP T+
Sbjct: 68 LGQKLLRLLVLTSVF--LVTLLQVGDRDDSNLYISAKMKAAAEIGIDAKHVRLPSSATQ 124
>UniRef50_P11586 Cluster: C-1-tetrahydrofolate synthase, cytoplasmic
(C1-THF synthase) [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate
synthetase (EC 6.3.4.3)]; n=86; cellular organisms|Rep:
C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF
synthase) [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate
synthetase (EC 6.3.4.3)] - Homo sapiens (Human)
Length = 935
Score = 99 bits (238), Expect = 3e-20
Identities = 45/88 (51%), Positives = 66/88 (75%), Gaps = 1/88 (1%)
Frame = +2
Query: 251 NKLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVG 430
++++ ITSLNE +VHG +VQ+P S+++ + V +A++P+KDVDGL +IN GR+ G
Sbjct: 79 SEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKDVDGLTSINAGRLARG 138
Query: 431 DLSG-XIPCTPAGCVELIXKTGVTIAGK 511
DL+ IPCTP GC+ELI +TGV IAG+
Sbjct: 139 DLNDCFIPCTPKGCLELIKETGVPIAGR 166
Score = 90.6 bits (215), Expect = 2e-17
Identities = 43/75 (57%), Positives = 57/75 (76%)
Frame = +3
Query: 27 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
A+I++G E++ I L+ QVT+L+ + GF PRLAI+QVG R DSN+YI +KLKAAE+I
Sbjct: 4 AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63
Query: 207 GIAAEHIRLPRDITE 251
GI A HI+LPR TE
Sbjct: 64 GIKATHIKLPRTTTE 78
>UniRef50_O84081 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Chlamydiaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Chlamydia trachomatis
Length = 287
Score = 80.6 bits (190), Expect = 2e-14
Identities = 37/85 (43%), Positives = 53/85 (62%)
Frame = +2
Query: 257 LLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDL 436
+LA I LN ++HGI+VQ+P DA + ++PDKDVDGL+ +N G++ +G+
Sbjct: 72 ILALIHQLNNDENIHGILVQLPLPKH--LDAQAILSTITPDKDVDGLHPVNVGKLLLGET 129
Query: 437 SGXIPCTPAGCVELIXKTGVTIAGK 511
G IPCTPAG VEL + + GK
Sbjct: 130 DGFIPCTPAGIVELCKYYEIPLHGK 154
Score = 39.1 bits (87), Expect = 0.060
Identities = 16/42 (38%), Positives = 25/42 (59%)
Frame = +3
Query: 123 PRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRDIT 248
P LA+V +G S +Y+ MK+K A +G+ ++ R P D T
Sbjct: 27 PGLAVVLIGNNPASEIYVNMKIKRATDLGMVSKSYRKPSDAT 68
>UniRef50_Q24UZ7 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Peptococcaceae|Rep: Bifunctional protein folD 2
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Desulfitobacterium hafniense (strain Y51)
Length = 284
Score = 80.6 bits (190), Expect = 2e-14
Identities = 39/85 (45%), Positives = 56/85 (65%)
Frame = +2
Query: 257 LLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDL 436
+LA I SLN +P VHGI++++P + + RV AV PDKDVDG++ IN G + G+
Sbjct: 77 ILALIDSLNANPDVHGIMIELPLPKHISKE--RVMAAVRPDKDVDGVHPINRGYILSGE- 133
Query: 437 SGXIPCTPAGCVELIXKTGVTIAGK 511
G P TP C+E++ ++GV IAGK
Sbjct: 134 EGLFPATPESCIEIMLRSGVEIAGK 158
Score = 50.8 bits (116), Expect = 2e-05
Identities = 27/78 (34%), Positives = 47/78 (60%)
Frame = +3
Query: 24 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEK 203
MAQ++ G E++ ++ +++++V R + + G P+LA+V VG S VY + K K ++
Sbjct: 1 MAQLLDGKEISKVLKEEIKEEVKRWKEQ--GVNPKLAVVLVGDDPASVVYAKSKQKVSDS 58
Query: 204 IGIAAEHIRLPRDITEIS 257
+GI E LP D +E S
Sbjct: 59 LGIDFELTVLPADSSEES 76
>UniRef50_Q9LHH7 Cluster: 5,10-methylenetetrahydrofolate
dehydrogenase/5,10- methenyltetrahydrofolate
cyclohydrolase; n=7; Eukaryota|Rep:
5,10-methylenetetrahydrofolate dehydrogenase/5,10-
methenyltetrahydrofolate cyclohydrolase - Arabidopsis
thaliana (Mouse-ear cress)
Length = 299
Score = 77.0 bits (181), Expect = 2e-13
Identities = 37/86 (43%), Positives = 57/86 (66%), Gaps = 1/86 (1%)
Frame = +2
Query: 257 LLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXV-GD 433
L++K+ LN +P VHGI+VQ+P H + H + A+S DKDVDG + +N G++ + G
Sbjct: 85 LISKVHELNSNPDVHGILVQLPLPK-HINEEH-ILGAISIDKDVDGFHPLNIGKLAMKGR 142
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
+PCTP GC+EL+ ++GV I G+
Sbjct: 143 EPLFLPCTPKGCLELLARSGVKIKGQ 168
>UniRef50_Q5IWX9 Cluster: Plastid 5,10-methylene-tetrahydrofolate
dehydrogenase; n=1; Prototheca wickerhamii|Rep: Plastid
5,10-methylene-tetrahydrofolate dehydrogenase -
Prototheca wickerhamii
Length = 248
Score = 77.0 bits (181), Expect = 2e-13
Identities = 38/87 (43%), Positives = 57/87 (65%), Gaps = 1/87 (1%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXV-G 430
++LA + N+ P+VHGI+VQ+P +H + RV DA+S +KDVDG + N G + + G
Sbjct: 137 EVLAVVAKFNDDPNVHGILVQLPLP-EHINEK-RVLDAISLEKDVDGFHPNNIGELAMRG 194
Query: 431 DLSGXIPCTPAGCVELIXKTGVTIAGK 511
+ CTP GC+EL+ + GVT+AGK
Sbjct: 195 RSPTYVSCTPKGCLELLKRAGVTLAGK 221
Score = 55.2 bits (127), Expect = 8e-07
Identities = 30/78 (38%), Positives = 47/78 (60%)
Frame = +3
Query: 18 AKMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAA 197
A A +I G ++A +I +L+ +V LR++++ P LA+V VG R DS Y+R K KA
Sbjct: 59 AMPAALIDGKKIAETIRGELKVEVDELRAQYNTV-PGLAVVLVGERKDSQTYVRSKKKAC 117
Query: 198 EKIGIAAEHIRLPRDITE 251
+++GI + LP TE
Sbjct: 118 DEVGINSFGADLPETATE 135
>UniRef50_Q83FS2 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Tropheryma whipplei|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Tropheryma whipplei (strain Twist)
(Whipple's bacillus)
Length = 295
Score = 76.2 bits (179), Expect = 4e-13
Identities = 37/86 (43%), Positives = 56/86 (65%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+L++K+ LN S V GIIVQ+P + D ++V +A++PDKD DGL+ +N G + G
Sbjct: 77 ELISKVEILNASSDVSGIIVQLPLPE--SIDQNKVIEAINPDKDADGLHPLNLGYLVTGK 134
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
G +PCTPAG V+L+ +T+ GK
Sbjct: 135 -QGIVPCTPAGIVKLLEAHRITLEGK 159
Score = 38.3 bits (85), Expect = 0.10
Identities = 23/76 (30%), Positives = 39/76 (51%)
Frame = +3
Query: 24 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEK 203
+A+++ G+ V+ I L + L + +G P+LA V VG S Y+ K + +
Sbjct: 2 VAKVLDGLAVSAGIFERLHRACCELEN--NGVCPKLATVLVGNNPASRSYVLSKHRDCKN 59
Query: 204 IGIAAEHIRLPRDITE 251
IGI + I LP + +E
Sbjct: 60 IGIQSTLIELPANTSE 75
>UniRef50_Q5PBL6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Alphaproteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Anaplasma marginale (strain St. Maries)
Length = 299
Score = 76.2 bits (179), Expect = 4e-13
Identities = 40/97 (41%), Positives = 52/97 (53%)
Frame = +2
Query: 218 RTYPLTKGHH*NKLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGL 397
RT L +LL I LN +VHGI+VQ+P D V +A+SP+KDVDG
Sbjct: 65 RTIALEHDTSQEELLRIIDELNRDAAVHGILVQLPLPRH--IDKELVINAISPEKDVDGF 122
Query: 398 NTINEGRVXVGDLSGXIPCTPAGCVELIXKTGVTIAG 508
+ N G++ G L IPCTP GC+ LI +AG
Sbjct: 123 HNANAGKLATGQLDCMIPCTPQGCIHLIKTVKQDLAG 159
>UniRef50_O65271 Cluster: F6N23.26 protein; n=20; Viridiplantae|Rep:
F6N23.26 protein - Arabidopsis thaliana (Mouse-ear
cress)
Length = 360
Score = 75.8 bits (178), Expect = 6e-13
Identities = 36/87 (41%), Positives = 55/87 (63%), Gaps = 1/87 (1%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXV-G 430
++L ++ N+ PSVHGI+VQ+P S D + +AVS +KDVDG + +N GR+ + G
Sbjct: 144 EVLKSVSGFNDDPSVHGILVQLPLPSH--MDEQNILNAVSIEKDVDGFHPLNIGRLAMRG 201
Query: 431 DLSGXIPCTPAGCVELIXKTGVTIAGK 511
+PCTP GC+EL+ + + I GK
Sbjct: 202 REPLFVPCTPKGCIELLHRYNIEIKGK 228
Score = 53.2 bits (122), Expect = 3e-06
Identities = 28/75 (37%), Positives = 44/75 (58%)
Frame = +3
Query: 27 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
A +I G VA I +++ +V+R++ G P LA++ VG R DS Y+R K KA + +
Sbjct: 69 AIVIDGKAVAKKIRDEITIEVSRMKES-IGVIPGLAVILVGDRKDSATYVRNKKKACDSV 127
Query: 207 GIAAEHIRLPRDITE 251
GI + +RL D +E
Sbjct: 128 GIKSFEVRLAEDSSE 142
>UniRef50_O65269 Cluster: F6N23.28 protein; n=1; Arabidopsis
thaliana|Rep: F6N23.28 protein - Arabidopsis thaliana
(Mouse-ear cress)
Length = 310
Score = 72.9 bits (171), Expect = 4e-12
Identities = 34/87 (39%), Positives = 54/87 (62%), Gaps = 1/87 (1%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXV-G 430
++L ++ N+ PSVHG++VQ+P S D + +AVS +KDVDG + +N GR+ + G
Sbjct: 94 EVLKYVSGFNDDPSVHGVLVQLPLPSH--MDEQNILNAVSIEKDVDGFHPLNIGRLAMRG 151
Query: 431 DLSGXIPCTPAGCVELIXKTGVTIAGK 511
+PCTP GC+EL+ + + GK
Sbjct: 152 REPLFVPCTPKGCIELLHRYNIEFKGK 178
>UniRef50_O83714 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Treponema pallidum
Length = 315
Score = 72.5 bits (170), Expect = 5e-12
Identities = 37/85 (43%), Positives = 53/85 (62%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
++L I LNE VHGI++Q+P + DA RV AV+P+KDVDG + +N G + +
Sbjct: 78 QVLELIARLNEDARVHGILIQLPLPAH--LDAARVCRAVAPEKDVDGFHPLNCGALFLAQ 135
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAG 508
G +PCTPAG V L+ + V +AG
Sbjct: 136 -PGFVPCTPAGIVHLLRRAQVPLAG 159
>UniRef50_A1AL91 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=9; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Pelobacter propionicus (strain DSM 2379)
Length = 283
Score = 72.5 bits (170), Expect = 5e-12
Identities = 37/86 (43%), Positives = 52/86 (60%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+LLA + LN P +HGI+VQ+P S D +V +A+SP KDVDG + N GR+ VG
Sbjct: 76 ELLALVELLNNDPKIHGILVQLPLPSQ--IDTDKVLEAISPFKDVDGFHPYNVGRLSVGK 133
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
PCTP G + ++ + GV + GK
Sbjct: 134 -PVFQPCTPYGVMVMLREAGVELKGK 158
>UniRef50_Q6ALZ5 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=27; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Desulfotalea psychrophila
Length = 296
Score = 72.5 bits (170), Expect = 5e-12
Identities = 36/86 (41%), Positives = 54/86 (62%), Gaps = 1/86 (1%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVG- 430
+LLA I N S+HG++VQ+P H + + +T A+ PDKDVD + +N GR+ +G
Sbjct: 78 ELLALIEKYNNDDSIHGVLVQLPLPK-HINEQNIIT-AIDPDKDVDAFHPVNIGRLMIGG 135
Query: 431 DLSGXIPCTPAGCVELIXKTGVTIAG 508
D +PCTPAG E++ ++GV AG
Sbjct: 136 DDVKFLPCTPAGIQEMLVRSGVETAG 161
>UniRef50_Q21285 Cluster: Dauer or aging adult overexpression
protein 3; n=2; Caenorhabditis|Rep: Dauer or aging adult
overexpression protein 3 - Caenorhabditis elegans
Length = 303
Score = 71.3 bits (167), Expect = 1e-11
Identities = 35/76 (46%), Positives = 45/76 (59%), Gaps = 1/76 (1%)
Frame = +2
Query: 257 LLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDL 436
L +I +LN + GII+Q+P H DA V D + P KDVDGL IN GR+ G+L
Sbjct: 80 LKREIMALNHDNEIDGIIIQLPLDCKHEIDADSVIDLIDPLKDVDGLTRINAGRLARGEL 139
Query: 437 SGXI-PCTPAGCVELI 481
I PCTP GC+ L+
Sbjct: 140 QRTIFPCTPFGCLYLV 155
Score = 69.3 bits (162), Expect = 5e-11
Identities = 34/76 (44%), Positives = 50/76 (65%)
Frame = +3
Query: 24 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEK 203
+A+I+SG+E + + +D+ Q++ + R F LAIVQVG R DSNVYI KLK A++
Sbjct: 2 VAEIVSGLEYSKKVLHDVGQKIAKTREHHPNFHAVLAIVQVGNRSDSNVYINSKLKKAKE 61
Query: 204 IGIAAEHIRLPRDITE 251
IG + I+LP IT+
Sbjct: 62 IGADGKLIKLPDTITQ 77
>UniRef50_Q54VK0 Cluster: Methenyl tetrahydrofolate cyclohydrolase /
NADP-dependent methylene H4F dehydrogenase; n=1;
Dictyostelium discoideum AX4|Rep: Methenyl
tetrahydrofolate cyclohydrolase / NADP-dependent
methylene H4F dehydrogenase - Dictyostelium discoideum
AX4
Length = 440
Score = 70.5 bits (165), Expect = 2e-11
Identities = 34/87 (39%), Positives = 52/87 (59%)
Frame = +2
Query: 251 NKLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVG 430
++L+ KI +E PSVHGIIVQ+P + DA + ++ P KDVDGL + N G++ +
Sbjct: 160 DQLIKKIKYHSEDPSVHGIIVQLPLPDNLNKDA--IIQSIDPKKDVDGLTSTNLGQIMIS 217
Query: 431 DLSGXIPCTPAGCVELIXKTGVTIAGK 511
IPCTP G +E++ + + GK
Sbjct: 218 KKPLYIPCTPLGILEILKAYKIKVEGK 244
>UniRef50_P13995 Cluster: Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor
[Includes: NAD-dependent methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)]; n=66; cellular
organisms|Rep: Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor
[Includes: NAD-dependent methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Homo sapiens (Human)
Length = 350
Score = 70.5 bits (165), Expect = 2e-11
Identities = 38/86 (44%), Positives = 53/86 (61%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+LL I LN +V G++VQ+P +H D R+ +AVSPDKDVDG + IN GR+ + D
Sbjct: 112 ELLNLINKLNNDDNVDGLLVQLPLP-EHI-DERRICNAVSPDKDVDGFHVINVGRMCL-D 168
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
+P TP G E+I +TG+ GK
Sbjct: 169 QYSMLPATPWGVWEIIKRTGIPTLGK 194
Score = 43.6 bits (98), Expect = 0.003
Identities = 25/75 (33%), Positives = 42/75 (56%)
Frame = +3
Query: 27 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
A +ISG ++A I+ ++RQ+V + P L+++ VG S+ Y+ K +AA +
Sbjct: 37 AVVISGRKLAQQIKQEVRQEVEEWVAS-GNKRPHLSVILVGENPASHSYVLNKTRAAAVV 95
Query: 207 GIAAEHIRLPRDITE 251
GI +E I P I+E
Sbjct: 96 GINSETIMKPASISE 110
>UniRef50_Q8KN38 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Sphingobium chlorophenolicum|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Sphingobium
chlorophenolicum
Length = 316
Score = 70.1 bits (164), Expect = 3e-11
Identities = 36/85 (42%), Positives = 49/85 (57%)
Frame = +2
Query: 257 LLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDL 436
LLA I SLN VHGI+VQ+P + D+ +V D + P KDVDG + +N R+ G
Sbjct: 78 LLALIASLNADERVHGILVQLPLPAQ--IDSGKVLDTIDPRKDVDGFHPVNVFRLSTG-T 134
Query: 437 SGXIPCTPAGCVELIXKTGVTIAGK 511
G +PCTP GC+ L+ + GK
Sbjct: 135 GGLVPCTPMGCMILLRSVLPDLKGK 159
Score = 52.8 bits (121), Expect = 5e-06
Identities = 29/76 (38%), Positives = 42/76 (55%)
Frame = +3
Query: 24 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEK 203
MA IISG A + DL + V R S+ G+ P L V VG S++Y+R K++ K
Sbjct: 1 MASIISGTAAAEGLLADLTRDVARF-SQVHGYAPTLVAVLVGDDPASHIYVRKKIEQCRK 59
Query: 204 IGIAAEHIRLPRDITE 251
+G+ + RLP D +E
Sbjct: 60 VGMESVEHRLPADCSE 75
>UniRef50_Q9A8Y0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=82; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Caulobacter crescentus (Caulobacter
vibrioides)
Length = 297
Score = 70.1 bits (164), Expect = 3e-11
Identities = 38/87 (43%), Positives = 48/87 (55%)
Frame = +2
Query: 251 NKLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVG 430
++LLA + LN P +HG++VQ P H V A+SPDKDVDGL N GR+ G
Sbjct: 78 DELLAVVAKLNADPKIHGVLVQFPVPP-HISQMD-VVAALSPDKDVDGLTVTNAGRLASG 135
Query: 431 DLSGXIPCTPAGCVELIXKTGVTIAGK 511
L PCTP GC+ LI + GK
Sbjct: 136 -LPALAPCTPTGCMMLIRDAIGDLKGK 161
Score = 40.3 bits (90), Expect = 0.026
Identities = 24/75 (32%), Positives = 39/75 (52%)
Frame = +3
Query: 27 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
A++I G A + + ++V L+++ G P LA+V VG S VY+R K +
Sbjct: 4 AKLIDGKAFAADLRAKIAEEVAALKAE-HGVTPGLAVVLVGEDPASQVYVRNKGEQTTAA 62
Query: 207 GIAAEHIRLPRDITE 251
G+ +E RLP T+
Sbjct: 63 GMYSETHRLPETTTQ 77
>UniRef50_Q16F77 Cluster: Methylenetetrahydrofolate dehydrogenase;
n=4; cellular organisms|Rep: Methylenetetrahydrofolate
dehydrogenase - Aedes aegypti (Yellowfever mosquito)
Length = 337
Score = 69.7 bits (163), Expect = 4e-11
Identities = 39/86 (45%), Positives = 54/86 (62%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+LL +I LN+ SV GI+VQ+P H + +V ++VS DKDVDG N N GR+ + D
Sbjct: 109 QLLKRIEELNQDDSVDGILVQLPVPG-HINE-RKVCNSVSCDKDVDGFNERNIGRLCL-D 165
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
++ IPCTP G ELI +T + GK
Sbjct: 166 MNTLIPCTPLGVQELIKRTEIETFGK 191
Score = 53.6 bits (123), Expect = 3e-06
Identities = 26/77 (33%), Positives = 42/77 (54%)
Frame = +3
Query: 21 KMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAE 200
+MA++I G ++A I +LR+Q+ + P L + +G SN Y+ K+KAA
Sbjct: 31 EMAKLIDGKQIAADIRMELREQIEEWMKQGGNRAPHLTAILIGEDPASNTYVSNKMKAAA 90
Query: 201 KIGIAAEHIRLPRDITE 251
+GI ++ R DITE
Sbjct: 91 DVGITSKTERYSADITE 107
>UniRef50_Q7MVE9 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=52; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Porphyromonas gingivalis (Bacteroides gingivalis)
Length = 296
Score = 69.7 bits (163), Expect = 4e-11
Identities = 36/86 (41%), Positives = 51/86 (59%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+LLA + LN+ P+V G IVQ+P D ++ +AV P KDVDG + IN GR+ +G
Sbjct: 80 ELLACVHRLNQDPTVDGFIVQLPLPKH--IDEQKIIEAVDPRKDVDGFHPINVGRLSIG- 136
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
L G + TP G VEL+ + + GK
Sbjct: 137 LPGFVSATPKGIVELLRRYNIPTRGK 162
>UniRef50_Q0AZF5 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Syntrophomonas wolfei subsp. wolfei str.
Goettingen|Rep: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Syntrophomonas wolfei subsp. wolfei (strain Goettingen)
Length = 277
Score = 69.7 bits (163), Expect = 4e-11
Identities = 33/86 (38%), Positives = 50/86 (58%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+L+AKI LN+ V GI++Q+P + + A+ PDKDVDG + +N GR+ GD
Sbjct: 72 ELMAKIAELNQDEQVDGILLQLPLPAALEEQTDEILAAIRPDKDVDGFSLVNRGRMS-GD 130
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
G I C C+E+I + ++AGK
Sbjct: 131 RPGFISCAALACLEVIERFFPSLAGK 156
Score = 41.5 bits (93), Expect = 0.011
Identities = 24/74 (32%), Positives = 40/74 (54%)
Frame = +3
Query: 30 QIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIG 209
+IISG ++A I L+++ R G P LA++ VGG+ + Y+ +K KAA G
Sbjct: 2 EIISGSQIAQEIRQKLKEKNER-----EGISPCLAMILVGGQKEDLHYVGLKEKAATATG 56
Query: 210 IAAEHIRLPRDITE 251
+ + LP D ++
Sbjct: 57 GKSRLLHLPEDTSQ 70
>UniRef50_Q63SL6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=226; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Burkholderia pseudomallei (Pseudomonas
pseudomallei)
Length = 285
Score = 68.5 bits (160), Expect = 9e-11
Identities = 35/95 (36%), Positives = 54/95 (56%)
Frame = +2
Query: 224 YPLTKGHH*NKLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNT 403
YP T +LLA+I LN P +HGI+VQ+P + D+H+V +A++P+KDVDG +
Sbjct: 69 YPATLSEP--ELLARIDELNRDPKIHGILVQLPLPAH--IDSHKVIEAIAPEKDVDGFHV 124
Query: 404 INEGRVXVGDLSGXIPCTPAGCVELIXKTGVTIAG 508
N G + G PCTP G +++ + + G
Sbjct: 125 ANAGALLTGK-PLFRPCTPYGVMKMFEAYKIPLQG 158
Score = 38.7 bits (86), Expect = 0.079
Identities = 22/75 (29%), Positives = 38/75 (50%)
Frame = +3
Query: 27 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
A +I G ++ ++ ++ L ++ G P LA++ VG S VY+R K+KA E
Sbjct: 3 ATLIDGNALSKTLRAQAAERAAALAAR--GHRPGLAVILVGDNPASEVYVRNKIKACEDN 60
Query: 207 GIAAEHIRLPRDITE 251
G + R P ++E
Sbjct: 61 GFFSLKDRYPATLSE 75
>UniRef50_A0JTZ0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=51; Actinobacteria (class)|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Arthrobacter sp. (strain FB24)
Length = 302
Score = 68.5 bits (160), Expect = 9e-11
Identities = 33/86 (38%), Positives = 51/86 (59%), Gaps = 3/86 (3%)
Frame = +2
Query: 263 AKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXV---GD 433
A I LN P+ HG IVQ+P DA + + + P KD DGL+ N GR+ + G+
Sbjct: 82 ALIDELNADPACHGYIVQLPLPKHLDTDA--ILERIDPAKDADGLHPTNLGRLVLNVSGE 139
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
++ +PCTP G +EL+ + G +++GK
Sbjct: 140 ITSPLPCTPRGVIELLERNGYSLSGK 165
>UniRef50_Q8TK95 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Methanosarcina acetivorans
Length = 290
Score = 68.1 bits (159), Expect = 1e-10
Identities = 31/87 (35%), Positives = 51/87 (58%), Gaps = 1/87 (1%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAX-DAHRVTDAVSPDKDVDGLNTINEGRVXVG 430
+LL I SLN++ VH I++Q+P + + +A+SP KD DG + N G++ +G
Sbjct: 83 ELLTLIDSLNKNKDVHAILLQLPLPKHFSPQETQEAMEAISPTKDADGFHPYNMGKLMIG 142
Query: 431 DLSGXIPCTPAGCVELIXKTGVTIAGK 511
D +PCTP G + + + GV++ GK
Sbjct: 143 D-EDLVPCTPHGVIRALEEYGVSVQGK 168
Score = 52.8 bits (121), Expect = 5e-06
Identities = 29/75 (38%), Positives = 43/75 (57%)
Frame = +3
Query: 27 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
++II G +A +E ++R V L S G P LA + VG S +Y+R+K +A E++
Sbjct: 8 SRIIDGKVLAQQVEEEVRSGVEDLESN-RGIVPGLATILVGDDPASKMYVRLKHRACERV 66
Query: 207 GIAAEHIRLPRDITE 251
GI AE LP D T+
Sbjct: 67 GIKAEDYLLPGDATQ 81
>UniRef50_Q8DMU0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=90; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Synechococcus elongatus (Thermosynechococcus
elongatus)
Length = 306
Score = 67.7 bits (158), Expect = 1e-10
Identities = 37/85 (43%), Positives = 51/85 (60%)
Frame = +2
Query: 257 LLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDL 436
LLAKIT LN+ V GI++Q+P D + A+ PDKDVDGL+ N GR+ V D
Sbjct: 82 LLAKITELNQDERVDGILLQLPLPPH--LDPRPLLYAIHPDKDVDGLHPENLGRL-VRDE 138
Query: 437 SGXIPCTPAGCVELIXKTGVTIAGK 511
G CTPAG ++L+ G+ + G+
Sbjct: 139 PGLRSCTPAGVMQLLAAYGIDVVGR 163
Score = 51.6 bits (118), Expect = 1e-05
Identities = 29/78 (37%), Positives = 42/78 (53%)
Frame = +3
Query: 18 AKMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAA 197
A A + G +A SIE L V +++W G P LA+++VG S VY+R K +A
Sbjct: 3 AHAATCLDGKSLAQSIERQLADHVRTFQAQW-GRSPGLAVLRVGNDPASAVYVRAKEQAC 61
Query: 198 EKIGIAAEHIRLPRDITE 251
++GI + LP ITE
Sbjct: 62 SRVGIQSFGAHLPATITE 79
>UniRef50_Q1II76 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Acidobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Acidobacteria bacterium (strain Ellin345)
Length = 307
Score = 67.7 bits (158), Expect = 1e-10
Identities = 33/84 (39%), Positives = 51/84 (60%)
Frame = +2
Query: 257 LLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDL 436
LL + SLN + GI+VQ+P D+ ++ AVSP+KDVDG + +N G +
Sbjct: 78 LLQLVESLNRRNDIDGILVQLPLPKQ--VDSKKILLAVSPEKDVDGFHPMNVGYLSTVR- 134
Query: 437 SGXIPCTPAGCVELIXKTGVTIAG 508
G +PCTPAGC+E++ ++ V + G
Sbjct: 135 PGLVPCTPAGCMEILRRSNVPVEG 158
>UniRef50_Q5SJ94 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermus thermophilus|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermus thermophilus (strain HB8 / ATCC
27634 / DSM 579)
Length = 282
Score = 66.5 bits (155), Expect = 3e-10
Identities = 37/85 (43%), Positives = 48/85 (56%)
Frame = +2
Query: 257 LLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDL 436
LL +I +LN V GI+VQ+P H RV +A+ P KDVDG + +N GR+ G
Sbjct: 75 LLERIAALNADEEVDGILVQLPLPP-HIR-TQRVLEAIHPLKDVDGFHPLNVGRLWSGG- 131
Query: 437 SGXIPCTPAGCVELIXKTGVTIAGK 511
G PCTP G V L+ GV + GK
Sbjct: 132 KGLFPCTPLGVVRLLKHYGVDLRGK 156
Score = 41.1 bits (92), Expect = 0.015
Identities = 25/75 (33%), Positives = 41/75 (54%)
Frame = +3
Query: 27 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
AQ++SG E A ++ ++R RLRS F P L ++++G S Y+R+K K A +
Sbjct: 3 AQVLSGHEAAEAVYEEIR---ARLRSL--SFTPSLRVIRLGEDPASVAYVRLKDKRARAL 57
Query: 207 GIAAEHIRLPRDITE 251
G ++ P D+ E
Sbjct: 58 GYRSQVEVYPEDLPE 72
>UniRef50_A5CF58 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Orientia tsutsugamushi Boryong|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Orientia tsutsugamushi
(strain Boryong) (Rickettsia tsutsugamushi)
Length = 301
Score = 66.5 bits (155), Expect = 3e-10
Identities = 36/86 (41%), Positives = 48/86 (55%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
KL + I LN +VHGIIVQ+P DA ++ + KDVDGLN IN G + +G
Sbjct: 77 KLFSVIDDLNCDSTVHGIIVQLPLPPH--IDALKLFARIDSRKDVDGLNPINIGYLNIGA 134
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
G IPCT GC++L+ + GK
Sbjct: 135 NQGLIPCTALGCIDLLQYYVTGLKGK 160
Score = 31.9 bits (69), Expect = 9.0
Identities = 22/76 (28%), Positives = 38/76 (50%)
Frame = +3
Query: 24 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEK 203
M I+ G ++A + + + L+ K+ +L I+ VG S +Y+ K+ A+
Sbjct: 1 MTVIMDGKKLAELRLIETKNDLLALKDKYQ-ITVKLVIILVGNNDASLIYVNNKVAKAKA 59
Query: 204 IGIAAEHIRLPRDITE 251
IG+ +E IRL I E
Sbjct: 60 IGMDSEIIRLFEFIEE 75
>UniRef50_Q8EQ43 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=45; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Oceanobacillus iheyensis
Length = 285
Score = 66.5 bits (155), Expect = 3e-10
Identities = 33/87 (37%), Positives = 50/87 (57%)
Frame = +2
Query: 251 NKLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVG 430
++LL I N SVHGI+VQ+P D ++ A+SP KDVDG + IN G++ G
Sbjct: 75 DELLQIIDEQNNDDSVHGILVQLPLPDQ--MDEQKIIHAISPAKDVDGFHPINVGKMMTG 132
Query: 431 DLSGXIPCTPAGCVELIXKTGVTIAGK 511
+ IPCTP G + ++ +++ GK
Sbjct: 133 E-DTFIPCTPYGILTMLRSKDISLEGK 158
>UniRef50_Q9ZD32 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Rickettsia|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rickettsia prowazekii
Length = 286
Score = 66.1 bits (154), Expect = 5e-10
Identities = 34/85 (40%), Positives = 47/85 (55%)
Frame = +2
Query: 257 LLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDL 436
L+ KI LN + GIIVQ+P S + D +++ AV P KD DG + +N G + G
Sbjct: 79 LILKINELNLDKGISGIIVQLPLPS--SIDENKILSAVLPSKDSDGFHPLNVGYLHSGIN 136
Query: 437 SGXIPCTPAGCVELIXKTGVTIAGK 511
G IPCT GC+ +I K + GK
Sbjct: 137 QGFIPCTALGCLAVIKKYAPNLNGK 161
Score = 41.5 bits (93), Expect = 0.011
Identities = 24/71 (33%), Positives = 39/71 (54%)
Frame = +3
Query: 33 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGI 212
II G +A I DL+ ++ + K + P+LAIV VG S +Y++ K+K A ++GI
Sbjct: 5 IIDGKALANEILADLKLEIQGFKEK-TKTSPKLAIVLVGDNPASMIYVKNKIKNAHQVGI 63
Query: 213 AAEHIRLPRDI 245
+ L +I
Sbjct: 64 DTLLVNLSTNI 74
>UniRef50_Q4RT28 Cluster: Chromosome 12 SCAF14999, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 12 SCAF14999, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 342
Score = 64.1 bits (149), Expect = 2e-09
Identities = 35/86 (40%), Positives = 51/86 (59%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+LL I LN V G++VQ+P +H D + +AV+P KDVDG + +N GR+ + D
Sbjct: 105 ELLDLIDKLNTDHRVDGLLVQLPLP-EHI-DERTICNAVAPTKDVDGFHVVNVGRMCL-D 161
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
S +P TP G E+I +TG+ GK
Sbjct: 162 QSSMLPATPWGVWEIIKRTGIPTLGK 187
>UniRef50_Q4FNW1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Pelagibacter ubique
Length = 281
Score = 63.7 bits (148), Expect = 2e-09
Identities = 32/85 (37%), Positives = 47/85 (55%)
Frame = +2
Query: 257 LLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDL 436
+L KI LN+ S+ GI+VQ+P D +V + + P KDVDG + +N G + G
Sbjct: 77 VLDKIEELNKDESISGILVQLPLPKH--IDKQKVIETILPGKDVDGFHPMNVGNLSSG-Y 133
Query: 437 SGXIPCTPAGCVELIXKTGVTIAGK 511
+PCTP GC +I K ++GK
Sbjct: 134 ESSVPCTPLGCYLMIKKIEPNLSGK 158
Score = 56.4 bits (130), Expect = 4e-07
Identities = 26/73 (35%), Positives = 44/73 (60%)
Frame = +3
Query: 33 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGI 212
+I G ++A + LRQ+V L++K + P L ++ +G S +Y+RMK KAA ++G+
Sbjct: 3 LIDGKKIAAELREQLRQEVVELKAKHNKI-PGLTVILIGEMAPSQIYVRMKEKAANEVGL 61
Query: 213 AAEHIRLPRDITE 251
+E IR P + E
Sbjct: 62 KSEVIRYPEAVEE 74
>UniRef50_Q3YRE3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Proteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Ehrlichia canis (strain Jake)
Length = 300
Score = 63.7 bits (148), Expect = 2e-09
Identities = 33/87 (37%), Positives = 47/87 (54%), Gaps = 1/87 (1%)
Frame = +2
Query: 251 NKLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVG 430
+ L+ KI LN +VHGI+VQ+P D + + + + P KDVDG + N GR+ G
Sbjct: 77 SSLIDKIHELNNDDNVHGILVQLPVPKH--IDKNLIINTIDPRKDVDGFHNDNVGRLFTG 134
Query: 431 DLSG-XIPCTPAGCVELIXKTGVTIAG 508
IPCTP GC+ LI ++G
Sbjct: 135 QKRNCLIPCTPRGCLYLIKTVTHNLSG 161
>UniRef50_Q6BNW9 Cluster: Debaryomyces hansenii chromosome E of
strain CBS767 of Debaryomyces hansenii; n=2;
Debaryomyces hansenii|Rep: Debaryomyces hansenii
chromosome E of strain CBS767 of Debaryomyces hansenii -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 276
Score = 62.9 bits (146), Expect = 4e-09
Identities = 34/86 (39%), Positives = 51/86 (59%), Gaps = 1/86 (1%)
Frame = +2
Query: 257 LLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXV-GD 433
LL +I LN+ P V+G+++Q+P H + +T+AV+ +KDVDG N G + G
Sbjct: 121 LLEEIDRLNKDPKVNGLLIQLPLPK-HFNET-LITNAVATEKDVDGFARYNVGELTKKGG 178
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
PCTP G +ELI TG+++ GK
Sbjct: 179 APMFKPCTPNGIMELIKTTGISLRGK 204
Score = 48.0 bits (109), Expect = 1e-04
Identities = 20/45 (44%), Positives = 30/45 (66%)
Frame = +3
Query: 117 FEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRDITE 251
F P L I+QVGGR DS+ Y++ KLKAA+ I + ++ D++E
Sbjct: 74 FRPNLTIIQVGGRPDSSAYVKAKLKAAKSSNILSSLLKFDEDMSE 118
>UniRef50_Q8RAD0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Thermoanaerobacter|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermoanaerobacter tengcongensis
Length = 280
Score = 62.5 bits (145), Expect = 6e-09
Identities = 30/87 (34%), Positives = 46/87 (52%)
Frame = +2
Query: 251 NKLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVG 430
+K + LNE HGI+++MP D +V D ++P KDVD ++ N GR+ G
Sbjct: 72 DKFFDTLEKLNEDKDTHGIMIEMPLPK--GFDVDKVYDTINPYKDVDCISNYNMGRLFAG 129
Query: 431 DLSGXIPCTPAGCVELIXKTGVTIAGK 511
+PCTP + ++ TGV + GK
Sbjct: 130 K-PLFVPCTPKAIIHILENTGVDLEGK 155
Score = 45.2 bits (102), Expect = 0.001
Identities = 22/63 (34%), Positives = 37/63 (58%)
Frame = +3
Query: 33 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGI 212
II G E++ I+ ++++++ G++PRLAI+ G S VY K+KA E +GI
Sbjct: 5 IIDGKEISNRIKEEVKREIQEF-----GYKPRLAILMAGDDESSKVYANSKVKACESVGI 59
Query: 213 AAE 221
A+
Sbjct: 60 EAK 62
>UniRef50_Q3AYX2 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=36; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Synechococcus sp. (strain CC9902)
Length = 293
Score = 62.5 bits (145), Expect = 6e-09
Identities = 32/86 (37%), Positives = 50/86 (58%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
++L+ I LN P V GI++Q+P D + A+ P+KD DGL+T+N GR+ G+
Sbjct: 77 EVLSTIQQLNADPRVDGILLQLPLPE--GLDEGPLLMAIDPEKDADGLHTLNLGRLLKGE 134
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
G CTPAG + ++ G+ AG+
Sbjct: 135 -QGPRSCTPAGVMAMLRSQGIDPAGQ 159
Score = 39.1 bits (87), Expect = 0.060
Identities = 24/71 (33%), Positives = 40/71 (56%)
Frame = +3
Query: 24 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEK 203
MA + G +A ++E+ L+ Q+ + +G P LA+++VG S VY+ K KA +
Sbjct: 1 MALRLDGKALAKAVESRLQAQIESNLPQ-AGRPPGLAVLRVGDDPASAVYVANKEKACAR 59
Query: 204 IGIAAEHIRLP 236
IG+A+ LP
Sbjct: 60 IGVASYGAHLP 70
>UniRef50_A1HML1 Cluster: Methenyltetrahydrofolate cyclohydrolase;
n=1; Thermosinus carboxydivorans Nor1|Rep:
Methenyltetrahydrofolate cyclohydrolase - Thermosinus
carboxydivorans Nor1
Length = 279
Score = 62.1 bits (144), Expect = 7e-09
Identities = 33/86 (38%), Positives = 48/86 (55%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
++LA + LNE +HGI+ MP A D RV A++PDKDVD L+ +N G V G
Sbjct: 76 EVLALVCELNEDDHIHGILPMMPLPPHLATD--RVAAALAPDKDVDALHPLNAGLVATGK 133
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
S PCTP + ++ + ++GK
Sbjct: 134 -SRWAPCTPRAVMAILDYYQIDVSGK 158
Score = 33.9 bits (74), Expect = 2.2
Identities = 24/76 (31%), Positives = 37/76 (48%)
Frame = +3
Query: 24 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEK 203
MA I+ G VA + + ++ +V L ++ LAI+ VG S +Y +K A
Sbjct: 1 MALILDGKAVAAAYKAKIKAKVDALAAQ--NITCGLAILLVGNDAASRIYADRLVKLATG 58
Query: 204 IGIAAEHIRLPRDITE 251
+G+ A LP D TE
Sbjct: 59 LGVQAVVRHLPADATE 74
>UniRef50_Q97HC9 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; Clostridium|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Clostridium acetobutylicum
Length = 278
Score = 61.7 bits (143), Expect = 1e-08
Identities = 33/86 (38%), Positives = 46/86 (53%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+L+ I LN +HGI++Q+P + DA VT + +KD+D L IN G+ G+
Sbjct: 77 ELIKLIEGLNVDNKIHGIMLQLPLPNH--IDAKLVTSKIDANKDIDSLTDINTGKFYKGE 134
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
S IPCTP + LI V I GK
Sbjct: 135 KS-FIPCTPRSIINLIKSLNVDICGK 159
>UniRef50_A7D6I9 Cluster: Methenyltetrahydrofolate cyclohydrolase;
n=1; Halorubrum lacusprofundi ATCC 49239|Rep:
Methenyltetrahydrofolate cyclohydrolase - Halorubrum
lacusprofundi ATCC 49239
Length = 307
Score = 60.9 bits (141), Expect = 2e-08
Identities = 36/85 (42%), Positives = 46/85 (54%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+L I LNE VHGI+VQ+P DH D RV ++P KDVDG + N GR+ GD
Sbjct: 86 ELYETIDDLNEREDVHGILVQLPVP-DHV-DKRRVLRQIAPVKDVDGFHPENVGRLVAGD 143
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAG 508
+ PCTP G +L+ V G
Sbjct: 144 -ARFKPCTPHGVQKLLAAYDVETEG 167
>UniRef50_Q4S6Y9 Cluster: Chromosome 14 SCAF14723, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 14 SCAF14723, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 1066
Score = 60.5 bits (140), Expect = 2e-08
Identities = 32/87 (36%), Positives = 51/87 (58%), Gaps = 1/87 (1%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+++ ++ L+E P VHG+ + +P A RV A+ P+KDVDGL+ +N G + GD
Sbjct: 64 EIVTEVLKLSEDPGVHGLYLHLP----QASLTSRVLTALKPEKDVDGLSDLNTGCLIRGD 119
Query: 434 LS-GXIPCTPAGCVELIXKTGVTIAGK 511
LS G +P + +E + K VT+ GK
Sbjct: 120 LSAGFVPPVTSAVLEWLSKHHVTLEGK 146
>UniRef50_UPI000038C811 Cluster: COG0190:
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl
tetrahydrofolate cyclohydrolase; n=1; Nostoc punctiforme
PCC 73102|Rep: COG0190: 5,10-methylene-tetrahydrofolate
dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase -
Nostoc punctiforme PCC 73102
Length = 292
Score = 60.1 bits (139), Expect = 3e-08
Identities = 32/81 (39%), Positives = 48/81 (59%)
Frame = +2
Query: 269 ITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGXI 448
I +LN+ V GI+VQ+P DH DA + + PDKD DGL+ +N GR+ G++ G
Sbjct: 86 IAALNDDERVDGILVQLPLP-DHL-DAVALLHQIDPDKDADGLHPVNLGRLVRGEI-GLR 142
Query: 449 PCTPAGCVELIXKTGVTIAGK 511
CTP G + L+ + + + GK
Sbjct: 143 SCTPDGVMRLLQEYEIPLQGK 163
Score = 47.6 bits (108), Expect = 2e-04
Identities = 26/76 (34%), Positives = 42/76 (55%)
Frame = +3
Query: 21 KMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAE 200
K A+++ G +A I+ +L +T+L+ + G P LA++ VG S Y+R K KA
Sbjct: 4 KTAKLLDGKAIAAKIQQELSVAITQLQPE-IGRPPGLAVLMVGDNPASAAYVRNKEKACA 62
Query: 201 KIGIAAEHIRLPRDIT 248
K+GIA+ P + T
Sbjct: 63 KVGIASFGKHFPAETT 78
>UniRef50_Q3A1Q7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Pelobacter carbinolicus (strain DSM 2380 / Gra Bd 1)
Length = 290
Score = 59.7 bits (138), Expect = 4e-08
Identities = 30/85 (35%), Positives = 46/85 (54%)
Frame = +2
Query: 257 LLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDL 436
LLA + N+SP V I+Q P D + + + P+KD DGL+ +N GR+ + +
Sbjct: 78 LLAAVRDFNDSPDVDAYIIQYPLPK--GFDFNEALNLMLPEKDADGLHPVNLGRLVLQE- 134
Query: 437 SGXIPCTPAGCVELIXKTGVTIAGK 511
G +PCTPAG ++ + I GK
Sbjct: 135 PGPVPCTPAGIRAMLQHYDIAIEGK 159
>UniRef50_Q6F1V0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Mollicutes|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mesoplasma florum (Acholeplasma florum)
Length = 286
Score = 58.8 bits (136), Expect = 7e-08
Identities = 28/86 (32%), Positives = 48/86 (55%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+L KI LN ++ GI++Q+P D + + A++P KDVDG + IN+G++ G
Sbjct: 76 ELYNKINELNNDQNIDGILLQLPLPIDFIEEDY--LQAITPSKDVDGFHYINQGKMLQG- 132
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
PCTP G + L+ + +++ K
Sbjct: 133 YDTVYPCTPLGIINLLEEYNISVKNK 158
Score = 45.6 bits (103), Expect = 7e-04
Identities = 22/71 (30%), Positives = 42/71 (59%)
Frame = +3
Query: 33 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGI 212
I+ G +VA + +L ++++ +K +P+L ++ VG S VY+ K+K A ++GI
Sbjct: 3 ILDGKKVASRRKEELTAKISKYHNKGLR-KPKLVVIMVGNDPASEVYVSHKIKVANEVGI 61
Query: 213 AAEHIRLPRDI 245
+E +R +DI
Sbjct: 62 YSELLRFDKDI 72
>UniRef50_UPI00015B49ED Cluster: PREDICTED: similar to putative
glyoxylate reductase/hydroxypyruvate reductase; n=1;
Nasonia vitripennis|Rep: PREDICTED: similar to putative
glyoxylate reductase/hydroxypyruvate reductase - Nasonia
vitripennis
Length = 699
Score = 58.4 bits (135), Expect = 9e-08
Identities = 32/86 (37%), Positives = 50/86 (58%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+LL ++ LN+ P+V G++VQ+P +H + V AV+P KDVDG + N G + + +
Sbjct: 103 ELLHEVQKLNDDPTVDGLLVQLP-VPEHISE-REVCQAVTPTKDVDGFHLSNIGNLALNN 160
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
G IP T G ELI ++ + GK
Sbjct: 161 -KGIIPATALGVKELIVRSKIPTFGK 185
Score = 41.5 bits (93), Expect = 0.011
Identities = 23/75 (30%), Positives = 38/75 (50%)
Frame = +3
Query: 27 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
A II G VA + +++ +V + P+L + VG S Y+ K+KAA+ +
Sbjct: 28 AAIIDGNGVADQVLEEVKAEVDEMTRNGEK-RPKLIAILVGNNPASKAYVGRKVKAAKTV 86
Query: 207 GIAAEHIRLPRDITE 251
GI +E +R IT+
Sbjct: 87 GIESETLRFEDSITQ 101
>UniRef50_O51057 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Borrelia burgdorferi group|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Borrelia burgdorferi
(Lyme disease spirochete)
Length = 308
Score = 58.4 bits (135), Expect = 9e-08
Identities = 29/85 (34%), Positives = 48/85 (56%)
Frame = +2
Query: 257 LLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDL 436
+L I N++ S GIIVQ+P D + + +++ KDVDGL+ +N G++ +GD
Sbjct: 83 ILEVIDRENKNLSTDGIIVQLPLLK--GMDLNSILNSIVYSKDVDGLSFVNLGKMILGDK 140
Query: 437 SGXIPCTPAGCVELIXKTGVTIAGK 511
G IPCT ++++ G+ GK
Sbjct: 141 KGFIPCTALAVLKILRDEGIKTLGK 165
>UniRef50_UPI000065DF90 Cluster: methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 2-like; n=1; Takifugu
rubripes|Rep: methylenetetrahydrofolate dehydrogenase
(NADP+ dependent) 2-like - Takifugu rubripes
Length = 400
Score = 58.0 bits (134), Expect = 1e-07
Identities = 30/86 (34%), Positives = 50/86 (58%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+LL I +N V G++VQ+P +H + V +A++P+KDVDG + +N G++ + D
Sbjct: 82 ELLELIDKMNRDWRVSGLLVQLPLP-EHINE-RAVCNAIAPEKDVDGFHIVNIGKLCL-D 138
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
+P TPA E+I + G+ GK
Sbjct: 139 QRSMVPATPAAVWEIIKRAGIETVGK 164
Score = 45.2 bits (102), Expect = 0.001
Identities = 22/77 (28%), Positives = 44/77 (57%)
Frame = +3
Query: 21 KMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAE 200
+ A +ISG E+A I+ ++++ V L ++ P L +V VG S Y++ K +AA
Sbjct: 5 RAAVVISGTELARQIQREIQRDVEELVAQ-GNMRPHLGVVLVGEDPASRTYVKNKTRAAS 63
Query: 201 KIGIAAEHIRLPRDITE 251
+GI+++ + P +++
Sbjct: 64 ILGISSDTVVRPSSVSQ 80
>UniRef50_A7DNA7 Cluster: Methylenetetrahydrofolate dehydrogenase
(NADP(+)); n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Methylenetetrahydrofolate dehydrogenase
(NADP(+)) - Candidatus Nitrosopumilus maritimus SCM1
Length = 287
Score = 58.0 bits (134), Expect = 1e-07
Identities = 31/81 (38%), Positives = 44/81 (54%)
Frame = +2
Query: 269 ITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGXI 448
I +LN SVHGI+VQ+P D T +SP KDVDGL N G + + + +
Sbjct: 82 IENLNNDNSVHGILVQLPLPEQ--LDEFTTTSRISPLKDVDGLTPHNAGLLAM-KKAALV 138
Query: 449 PCTPAGCVELIXKTGVTIAGK 511
CTP+G +E+ G+ + GK
Sbjct: 139 ACTPSGVMEMFDYHGIELEGK 159
Score = 39.9 bits (89), Expect = 0.034
Identities = 22/72 (30%), Positives = 40/72 (55%)
Frame = +3
Query: 36 ISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIA 215
I G ++ S+++ +++ V L+++ G P LA V VG S Y+R K +A E++GI
Sbjct: 6 IDGKVISQSVKDRVKKAVEELKNQ--GINPCLATVLVGDNPASATYVRNKHRACEEVGIT 63
Query: 216 AEHIRLPRDITE 251
+ +L T+
Sbjct: 64 TKDHKLDASTTQ 75
>UniRef50_Q9HPY4 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Halobacterium salinarium (Halobacterium
halobium)
Length = 297
Score = 58.0 bits (134), Expect = 1e-07
Identities = 35/80 (43%), Positives = 42/80 (52%)
Frame = +2
Query: 257 LLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDL 436
L + LN VHGI+VQ P DH D RV AV P KDVDG + N G++ VG
Sbjct: 77 LFDTVAELNAREDVHGILVQDPTP-DHVPD-ERVLSAVDPAKDVDGFHPENVGKL-VGGT 133
Query: 437 SGXIPCTPAGCVELIXKTGV 496
PCTP G +L+ GV
Sbjct: 134 PRFKPCTPHGVQKLLAHQGV 153
Score = 48.8 bits (111), Expect = 7e-05
Identities = 27/70 (38%), Positives = 39/70 (55%)
Frame = +3
Query: 24 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEK 203
M +II G VA + DL V L + +G PRLA V + + S Y+ MK + E+
Sbjct: 1 MTEIIDGDAVAAQLRADLTGAVETLET--AGVTPRLATVLMNDKQASETYVSMKQQDCEE 58
Query: 204 IGIAAEHIRL 233
+GIAAE +R+
Sbjct: 59 VGIAAEDVRI 68
>UniRef50_Q74GN1 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Bacteria|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Geobacter sulfurreducens
Length = 290
Score = 58.0 bits (134), Expect = 1e-07
Identities = 32/87 (36%), Positives = 49/87 (56%)
Frame = +2
Query: 251 NKLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVG 430
++LLAKI +NE P+ G+IVQ+P H H V +A++P+KD+DG + N GR+ +G
Sbjct: 75 SELLAKIKEVNEDPTTDGLIVQLPLPK-HINQQH-VINAIAPEKDIDGFHPANFGRMTLG 132
Query: 431 DLSGXIPCTPAGCVELIXKTGVTIAGK 511
P T G +L+ V + K
Sbjct: 133 Q-KAFRPATAYGICKLLQFYEVPVKAK 158
>UniRef50_Q6F9E6 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Proteobacteria|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Acinetobacter sp. (strain ADP1)
Length = 297
Score = 58.0 bits (134), Expect = 1e-07
Identities = 30/77 (38%), Positives = 43/77 (55%)
Frame = +2
Query: 251 NKLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVG 430
++LL +I LN VHGI+VQ+P + RV + + P KDVDG ++ N G + G
Sbjct: 84 DELLTQIDRLNTERGVHGILVQLPLPKQ--INETRVLERIHPQKDVDGFHSENVGGLSQG 141
Query: 431 DLSGXIPCTPAGCVELI 481
PCTP GC+ L+
Sbjct: 142 -RDVLTPCTPTGCIRLL 157
Score = 47.6 bits (108), Expect = 2e-04
Identities = 26/74 (35%), Positives = 44/74 (59%)
Frame = +3
Query: 30 QIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIG 209
+II G +A S+ +++ +V R +++ G EP LA+V VG S VY+R K++ A +G
Sbjct: 12 KIIDGKAIAQSVLEEVKLEVERYKAQ--GIEPCLAVVLVGEDPASQVYVRNKVQKAAFVG 69
Query: 210 IAAEHIRLPRDITE 251
I + R D++E
Sbjct: 70 IRSLEFRFDADLSE 83
>UniRef50_Q9KQQ6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=44; Gammaproteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Vibrio cholerae
Length = 286
Score = 57.6 bits (133), Expect = 2e-07
Identities = 28/85 (32%), Positives = 47/85 (55%)
Frame = +2
Query: 257 LLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDL 436
LL+ + LN P + GI+VQ+P + D +V +++ P+KDVDG + N GR+ +
Sbjct: 79 LLSLVEELNNDPQIDGILVQLPLPA--GMDTTKVLESIHPEKDVDGFHPYNVGRL-AQRI 135
Query: 437 SGXIPCTPAGCVELIXKTGVTIAGK 511
CTP G + L+ + + + GK
Sbjct: 136 PKLRSCTPKGIITLLERYNIPLRGK 160
>UniRef50_A3PVV6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; Actinobacteridae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycobacterium sp. (strain JLS)
Length = 288
Score = 57.6 bits (133), Expect = 2e-07
Identities = 32/85 (37%), Positives = 45/85 (52%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+L A I LN +P G IVQ+P D + + + P KD DGL+ N GR+ + +
Sbjct: 80 ELDATIDELNANPECTGYIVQLPLPKH--LDENAALERIDPGKDADGLHPTNLGRLVLNE 137
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAG 508
+PCTP G V L+ + V IAG
Sbjct: 138 -PAPLPCTPRGIVHLLRRYEVEIAG 161
Score = 33.5 bits (73), Expect = 3.0
Identities = 21/60 (35%), Positives = 30/60 (50%)
Frame = +3
Query: 72 DLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRDITE 251
DL+++V L + G P L V VG S Y+R K K+GI + LP DI++
Sbjct: 21 DLKERVAALTEQ--GRTPGLGTVLVGDDPGSQAYVRGKHSDCAKVGINSIRRDLPADISQ 78
>UniRef50_Q8ZZK1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Pyrobaculum|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Pyrobaculum aerophilum
Length = 311
Score = 55.2 bits (127), Expect = 8e-07
Identities = 34/86 (39%), Positives = 45/86 (52%), Gaps = 2/86 (2%)
Frame = +2
Query: 260 LAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVG-DL 436
L I SLN V G+I+Q P D + A+SP+KDVD L N+ R+ DL
Sbjct: 85 LRLIESLNRRDDVTGVIIQKPLPP--FVDEKALFSALSPEKDVDALTPENKKRLLTDFDL 142
Query: 437 SGXI-PCTPAGCVELIXKTGVTIAGK 511
+ PCTPAG +EL G+ + GK
Sbjct: 143 DRDVLPCTPAGILELFKLYGIDVRGK 168
>UniRef50_A4EAK0 Cluster: Putative uncharacterized protein; n=3;
Bacteria|Rep: Putative uncharacterized protein -
Collinsella aerofaciens ATCC 25986
Length = 284
Score = 54.8 bits (126), Expect = 1e-06
Identities = 30/76 (39%), Positives = 44/76 (57%)
Frame = +3
Query: 24 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEK 203
MA+++ G VA ++ +L + LR + G P LAIV+VG R D Y R LK EK
Sbjct: 1 MAELLKGAPVARALTEELAARCAALREQ--GVVPMLAIVRVGEREDDLSYERGALKRCEK 58
Query: 204 IGIAAEHIRLPRDITE 251
+GI A + LP D+++
Sbjct: 59 VGIEARRVLLPVDVSQ 74
Score = 46.4 bits (105), Expect = 4e-04
Identities = 28/86 (32%), Positives = 41/86 (47%)
Frame = +2
Query: 251 NKLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVG 430
++LLA I +N P+VHG ++ P + DA V A+ P KDVD + + G
Sbjct: 75 DELLAAIKDINADPAVHGCLMFRPLPAGLDEDA--VAAALDPAKDVDSMTPASLLTTLSG 132
Query: 431 DLSGXIPCTPAGCVELIXKTGVTIAG 508
G PCT + L+ GV + G
Sbjct: 133 RGEGFAPCTAEAVLALLDHYGVELDG 158
>UniRef50_Q86F84 Cluster: Clone ZZD1003 mRNA sequence; n=1;
Schistosoma japonicum|Rep: Clone ZZD1003 mRNA sequence -
Schistosoma japonicum (Blood fluke)
Length = 332
Score = 53.6 bits (123), Expect = 3e-06
Identities = 26/73 (35%), Positives = 45/73 (61%)
Frame = +3
Query: 33 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGI 212
I+ G +VA ++ + ++ V L+S + + P+L +++VG S +YI+ K K A+K GI
Sbjct: 6 ILYGRQVAQAVGHKIKLDVALLKSSFDVY-PKLVVIEVGELPQSKLYIKQKFKFAKKYGI 64
Query: 213 AAEHIRLPRDITE 251
H+RLP I+E
Sbjct: 65 LLSHMRLPSHISE 77
Score = 47.2 bits (107), Expect = 2e-04
Identities = 32/94 (34%), Positives = 43/94 (45%), Gaps = 10/94 (10%)
Frame = +2
Query: 257 LLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDL 436
LL + LN SVHGI +Q+P SD + +AV+ KDV+GLN+ N + V
Sbjct: 80 LLDYVYKLNADSSVHGITLQLPFDSDTNINVTNSLNAVATHKDVEGLNSYNTALLSVVIY 139
Query: 437 SGXI----------PCTPAGCVELIXKTGVTIAG 508
S + CT A C LI I+G
Sbjct: 140 SATLRRLKTKTYSYTCTAAACYALIRHVNFPISG 173
>UniRef50_P56467 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Helicobacter pylori (Campylobacter pylori)
Length = 290
Score = 53.6 bits (123), Expect = 3e-06
Identities = 27/86 (31%), Positives = 45/86 (52%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
KLL+ I N ++ G++VQ+P D + +A+ P+KDVDG + +N G++
Sbjct: 81 KLLSLIKDYNTDQNISGVLVQLPLPRH--IDTKMILEAIDPNKDVDGFHPLNIGKLCT-Q 137
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
+P TP G + L+ + I GK
Sbjct: 138 KESFLPATPMGVMRLLEHYHIEIKGK 163
Score = 45.2 bits (102), Expect = 0.001
Identities = 23/73 (31%), Positives = 44/73 (60%)
Frame = +3
Query: 33 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGI 212
++ G +A +IE DL+ ++ + ++ + P+LA++ VG S Y+ MK+KA E++G+
Sbjct: 8 LLDGQALADNIEKDLKHKIQIITAQ-THKRPKLAVILVGKDPASITYVNMKIKACERVGM 66
Query: 213 AAEHIRLPRDITE 251
+ L +ITE
Sbjct: 67 DFDLKTLQENITE 79
>UniRef50_A5V1H2 Cluster: Methylenetetrahydrofolate dehydrogenase
(NADP(+)); n=5; Chloroflexi (class)|Rep:
Methylenetetrahydrofolate dehydrogenase (NADP(+)) -
Roseiflexus sp. RS-1
Length = 288
Score = 52.8 bits (121), Expect = 5e-06
Identities = 27/81 (33%), Positives = 47/81 (58%)
Frame = +2
Query: 269 ITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGXI 448
I++L+ ++HGI++ +P D+ R + P KDVDG++ N G + +G G I
Sbjct: 83 ISALSFDRTIHGILLHLPLPP--GLDSARAIAQIDPAKDVDGVHPYNAGLLAMG-RPGLI 139
Query: 449 PCTPAGCVELIXKTGVTIAGK 511
P TPAG +EL+ + + + G+
Sbjct: 140 PNTPAGGMELLLRNNIPLKGQ 160
>UniRef50_Q4FTX6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=24; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Psychrobacter arcticum
Length = 295
Score = 52.8 bits (121), Expect = 5e-06
Identities = 29/85 (34%), Positives = 45/85 (52%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+L+AKI LN +P VHGI++Q P + D + + KDVDG+ + GR+ +
Sbjct: 89 ELMAKIDELNNNPDVHGILLQHPVPAH--IDERACFEQIDLAKDVDGVTCLGFGRMAM-Q 145
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAG 508
S CTP G + L+ + +AG
Sbjct: 146 QSAYGSCTPQGIMHLLEHHNIELAG 170
>UniRef50_Q7TU81 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Prochlorococcus marinus|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Prochlorococcus marinus subsp. pastoris
(strain CCMP 1378 / MED4)
Length = 298
Score = 52.8 bits (121), Expect = 5e-06
Identities = 28/81 (34%), Positives = 44/81 (54%)
Frame = +2
Query: 269 ITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGXI 448
+ LN ++ G+++Q+P D R+ ++P+KDVDGLN N G++ V +
Sbjct: 82 LNKLNLDNNIDGMLLQLPISKKF--DEQRLISFINPEKDVDGLNEQNIGKL-VKNEQAMR 138
Query: 449 PCTPAGCVELIXKTGVTIAGK 511
CTPAG V L+ + I GK
Sbjct: 139 SCTPAGIVNLLKSQNIKIEGK 159
>UniRef50_Q987T6 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Alphaproteobacteria|Rep: Bifunctional protein folD
2 [Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rhizobium loti (Mesorhizobium loti)
Length = 306
Score = 52.4 bits (120), Expect = 6e-06
Identities = 34/100 (34%), Positives = 49/100 (49%)
Frame = +2
Query: 209 YRRRTYPLTKGHH*NKLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDV 388
+ R +P T +L A I LN P V GII+Q P + + AV P KDV
Sbjct: 68 FEERRFPATITS--GELEAAIHGLNADPRVTGIIIQRPVPAH--ISVKTLQAAVHPLKDV 123
Query: 389 DGLNTINEGRVXVGDLSGXIPCTPAGCVELIXKTGVTIAG 508
+G++ + G + L PCT A VEL+ +TG+ + G
Sbjct: 124 EGMHPASIGNIVYNQLD-LAPCTAAASVELLKETGLDLKG 162
Score = 33.9 bits (74), Expect = 2.2
Identities = 18/49 (36%), Positives = 25/49 (51%)
Frame = +3
Query: 102 SKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRDIT 248
+K GF P+L + VG +VY+R + A+ GI E R P IT
Sbjct: 30 AKAEGFPPKLISITVGDTDAVDVYVRNQRAKAQLAGIDFEERRFPATIT 78
>UniRef50_Q6D2E6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Erwinia carotovora subsp. atroseptica (Pectobacterium
atrosepticum)
Length = 287
Score = 52.0 bits (119), Expect = 8e-06
Identities = 32/97 (32%), Positives = 49/97 (50%)
Frame = +2
Query: 218 RTYPLTKGHH*NKLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGL 397
R+Y L ++LLA I LN ++ GI+VQ+P D +V + ++PDKDVDG
Sbjct: 66 RSYDLPITTTESELLALIDQLNADQAIDGILVQLPLPE--GIDNTKVIERIAPDKDVDGF 123
Query: 398 NTINEGRVXVGDLSGXIPCTPAGCVELIXKTGVTIAG 508
+ N GR+ CTP G + L+ + + G
Sbjct: 124 HPYNVGRL-CQRAPLLRACTPRGIITLLERYNIDTFG 159
>UniRef50_Q5FJG5 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Firmicutes|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Lactobacillus acidophilus
Length = 283
Score = 51.6 bits (118), Expect = 1e-05
Identities = 27/81 (33%), Positives = 44/81 (54%)
Frame = +2
Query: 269 ITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGXI 448
I LNE P ++G++VQ+P + DA + + + P+KDVDGL N GR+ + +
Sbjct: 81 IDKLNEDPDINGVMVQLP--APEQIDADELLERIDPNKDVDGLTPSNIGRIWM-ENHFIE 137
Query: 449 PCTPAGCVELIXKTGVTIAGK 511
P T G + L+ + + GK
Sbjct: 138 PATAEGIIALLKYYKILLKGK 158
Score = 46.4 bits (105), Expect = 4e-04
Identities = 23/73 (31%), Positives = 40/73 (54%)
Frame = +3
Query: 24 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEK 203
M +I+ G VA + L+++V L+ + G P ++ +G S +Y+R K + AEK
Sbjct: 1 MGKILDGKFVANLLGEKLKEKVKDLKEE--GITPHFCVINIGDDPASKIYVRTKKRRAEK 58
Query: 204 IGIAAEHIRLPRD 242
+GI + +LP D
Sbjct: 59 MGIIQDIYQLPAD 71
>UniRef50_Q189R8 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=11; Clostridiales|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Clostridium difficile (strain 630)
Length = 290
Score = 51.6 bits (118), Expect = 1e-05
Identities = 31/74 (41%), Positives = 40/74 (54%)
Frame = +3
Query: 30 QIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIG 209
QII G VA I +L ++V L + G P+L IV+VG R D Y R LK + IG
Sbjct: 9 QIIKGKPVADKISEELIKEVDLLVKE--GINPKLTIVRVGARSDDLSYERGALKRCQNIG 66
Query: 210 IAAEHIRLPRDITE 251
I E + L DIT+
Sbjct: 67 ITTEVLELAEDITQ 80
Score = 50.0 bits (114), Expect = 3e-05
Identities = 26/77 (33%), Positives = 41/77 (53%)
Frame = +2
Query: 278 LNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGXIPCT 457
+N+ +V+GI+ P H + + ++P+KDVD + IN +V GD SG PCT
Sbjct: 90 VNDDKNVNGILCFRPLPK-HLNE-EVIKYVIAPEKDVDCFSPINSAKVMEGDKSGFPPCT 147
Query: 458 PAGCVELIXKTGVTIAG 508
P VE++ V + G
Sbjct: 148 PTAVVEILKHYNVDLKG 164
>UniRef50_Q0SFQ8 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Actinomycetales|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rhodococcus sp. (strain RHA1)
Length = 297
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/82 (34%), Positives = 43/82 (52%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
++ + + L P VHGII+Q P DA R +A++P KDVDG N ++ GR+ V
Sbjct: 76 QIRSTLVELGHDPDVHGIILQTPLPDGTDLDALR--EAINPAKDVDGANPVSLGRL-VAR 132
Query: 434 LSGXIPCTPAGCVELIXKTGVT 499
L P T + L+ G++
Sbjct: 133 LPAFAPATAQAVIALLDHHGIS 154
Score = 35.5 bits (78), Expect = 0.73
Identities = 22/70 (31%), Positives = 33/70 (47%)
Frame = +3
Query: 24 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEK 203
M + + G E+A SI ND L G P+LA+VQ + Y+R AA++
Sbjct: 1 MTRSLGGAELATSIRNDASVAAAALNDL--GTRPKLAVVQATDDESTAWYVRSIASAAKR 58
Query: 204 IGIAAEHIRL 233
GI + + L
Sbjct: 59 TGILCDIVDL 68
>UniRef50_Q5RGD2 Cluster: Novel protein similar to vertebrate
formyltetrahydrofolate synthetase domain containing 1;
n=1; Danio rerio|Rep: Novel protein similar to
vertebrate formyltetrahydrofolate synthetase domain
containing 1 - Danio rerio (Zebrafish) (Brachydanio
rerio)
Length = 217
Score = 50.8 bits (116), Expect = 2e-05
Identities = 29/82 (35%), Positives = 45/82 (54%), Gaps = 1/82 (1%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+++ ++ LN+ VHGI + +P + V +A+ P KDVDG+ +N GRV +GD
Sbjct: 63 EVIEEVLRLNKDSRVHGIFLHLP----QTFLSKSVRNAIKPQKDVDGVCDLNVGRVVLGD 118
Query: 434 LSGXIPCTPAGCV-ELIXKTGV 496
+ AG V EL+ K GV
Sbjct: 119 KTDGFTSPVAGAVLELLAKHGV 140
>UniRef50_Q2B9L0 Cluster: Bifunctional protein FolD; n=1; Bacillus
sp. NRRL B-14911|Rep: Bifunctional protein FolD -
Bacillus sp. NRRL B-14911
Length = 322
Score = 50.4 bits (115), Expect = 2e-05
Identities = 30/87 (34%), Positives = 46/87 (52%), Gaps = 1/87 (1%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+L+ I LNE+ VHGI++Q P D + + +S DKDVDG+ + G+ +G
Sbjct: 117 ELVKTIEELNENKEVHGILLQHPVPGH--IDERKAFETISIDKDVDGVTSHGYGQTALG- 173
Query: 434 LSGXIP-CTPAGCVELIXKTGVTIAGK 511
G P CTPA + +I + + GK
Sbjct: 174 -FGTYPSCTPAAIMAIIDYYHLPVEGK 199
Score = 49.2 bits (112), Expect = 6e-05
Identities = 26/72 (36%), Positives = 38/72 (52%)
Frame = +3
Query: 33 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGI 212
I+ G VA ++ L +V L K G P LA + VG S Y+RMK A ++GI
Sbjct: 45 ILDGKRVAADVKEGLMPRVENLTQK--GITPCLATILVGDDPSSETYVRMKGNACARLGI 102
Query: 213 AAEHIRLPRDIT 248
+E I +P++ T
Sbjct: 103 RSERIHMPKETT 114
>UniRef50_Q0AWX5 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Syntrophomonas wolfei subsp. wolfei str.
Goettingen|Rep: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Syntrophomonas wolfei subsp. wolfei (strain Goettingen)
Length = 272
Score = 50.0 bits (114), Expect = 3e-05
Identities = 26/86 (30%), Positives = 47/86 (54%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+LL I LN S + GI++Q P + + +A + +A+ DKDV+G++ N G++ +
Sbjct: 69 ELLKTIGDLNNSSEITGIMLQTPLPA--SLNASHLVNAIDFDKDVEGIHNYNLGKL-ISK 125
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
G PCTP + ++ + I G+
Sbjct: 126 EEGVRPCTPKAVISMLKAHDILIEGQ 151
Score = 37.1 bits (82), Expect = 0.24
Identities = 21/61 (34%), Positives = 33/61 (54%), Gaps = 1/61 (1%)
Frame = +3
Query: 72 DLRQQVT-RLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRDIT 248
D+R+Q+ R+R + LAI++VG S Y+R K AE+ G+ E + LP +
Sbjct: 7 DIREQIKERVRQSAEEVKMGLAIIRVGDDPSSMAYVRGIRKFAEETGVKVEIVNLPDAVG 66
Query: 249 E 251
E
Sbjct: 67 E 67
>UniRef50_UPI0000DB7ABF Cluster: PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor; n=1; Apis mellifera|Rep:
PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor - Apis mellifera
Length = 407
Score = 49.6 bits (113), Expect = 4e-05
Identities = 29/85 (34%), Positives = 46/85 (54%)
Frame = +2
Query: 257 LLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDL 436
++ +I +LN+ +V GI+VQ+P H + V A+ P KDVDG + N G + + +
Sbjct: 186 IINEIDNLNKDKTVDGILVQLPLIK-HMNE-QEVCQAIIPSKDVDGFHLENLGNLAL-NR 242
Query: 437 SGXIPCTPAGCVELIXKTGVTIAGK 511
+G IP T ELI + + GK
Sbjct: 243 NGIIPATALAVKELIIRNNIETFGK 267
Score = 40.3 bits (90), Expect = 0.026
Identities = 24/69 (34%), Positives = 37/69 (53%)
Frame = +3
Query: 27 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
A II G ++A I+N+L+ V + + P+L ++VG S +Y+ K+KAA I
Sbjct: 110 AIIIDGKKIANKIQNELKITVDNWIND-NKKRPKLVAIKVGNNPASKIYVEKKIKAANFI 168
Query: 207 GIAAEHIRL 233
GI I L
Sbjct: 169 GIENYTIHL 177
>UniRef50_Q2JCX4 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Frankia|Rep: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Frankia sp. (strain CcI3)
Length = 276
Score = 49.6 bits (113), Expect = 4e-05
Identities = 28/84 (33%), Positives = 45/84 (53%)
Frame = +2
Query: 257 LLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDL 436
+L I ++ P+VHGIIVQ P + V + + KDVDG+N + GR+ +G L
Sbjct: 74 ILDTIDTVAADPTVHGIIVQTPLPG--GLTSREVGEHIPTAKDVDGMNPSSLGRLALG-L 130
Query: 437 SGXIPCTPAGCVELIXKTGVTIAG 508
P T A VE++ + + ++G
Sbjct: 131 PSFAPATAAAVVEILTRARIPMSG 154
>UniRef50_Q8W528 Cluster: Methylenetetrahydrofolate
dehydrogenase/methylenetetrahydrofolate cylcohydrolase
isoform 1; n=11; Viridiplantae|Rep:
Methylenetetrahydrofolate
dehydrogenase/methylenetetrahydrofolate cylcohydrolase
isoform 1 - Zea mays (Maize)
Length = 160
Score = 49.2 bits (112), Expect = 6e-05
Identities = 20/46 (43%), Positives = 33/46 (71%), Gaps = 1/46 (2%)
Frame = +2
Query: 377 DKDVDGLNTINEGRVXV-GDLSGXIPCTPAGCVELIXKTGVTIAGK 511
+KDVDG + +N G++ + G +PCTP GC+EL+ ++G++I GK
Sbjct: 1 EKDVDGFHPLNIGKLAMKGRQPLFLPCTPKGCIELLHRSGISIKGK 46
>UniRef50_Q04FB7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Leuconostocaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Oenococcus oeni (strain BAA-331 / PSU-1)
Length = 285
Score = 48.4 bits (110), Expect = 1e-04
Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 1/86 (1%)
Frame = +2
Query: 257 LLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDL 436
+L ++ LN S+ GI+VQ P D ++ +A+ P KD DGL+ N+G +
Sbjct: 74 ILRLLSKLNMDSSICGILVQSPLGD--GIDESKIFNAIDPLKDADGLSAFNQGLLFENAK 131
Query: 437 SGXI-PCTPAGCVELIXKTGVTIAGK 511
I P TPAG + L+ A K
Sbjct: 132 ENYIVPATPAGVISLLEAYHYQFAAK 157
>UniRef50_Q4A6B1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma synoviae 53|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Mycoplasma synoviae (strain 53)
Length = 278
Score = 47.6 bits (108), Expect = 2e-04
Identities = 29/74 (39%), Positives = 43/74 (58%)
Frame = +3
Query: 30 QIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIG 209
+I+SG E A E DL+Q L +LAI+QVG + +SN Y+ KLK A++IG
Sbjct: 2 KILSGREKA---EQDLKQLKKELDELNLNRPIKLAIIQVGDKMESNRYVEQKLKKAKEIG 58
Query: 210 IAAEHIRLPRDITE 251
I A+ + +IT+
Sbjct: 59 IEAKCFKFDENITQ 72
>UniRef50_Q74J95 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Lactobacillus|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Lactobacillus johnsonii
Length = 283
Score = 47.6 bits (108), Expect = 2e-04
Identities = 25/78 (32%), Positives = 44/78 (56%), Gaps = 2/78 (2%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
++L I N+ P++H I++Q+P H + +A++P+KDVDG N+ N G++ +
Sbjct: 76 EVLQAIHHYNDDPTIHAILIQLPLPK-HLNQTELI-EAIAPEKDVDGFNSKNVGKLYNNE 133
Query: 434 LSGXIP--CTPAGCVELI 481
G P CT G + L+
Sbjct: 134 -EGHYPVSCTSRGIMTLL 150
Score = 45.2 bits (102), Expect = 0.001
Identities = 22/76 (28%), Positives = 44/76 (57%)
Frame = +3
Query: 24 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEK 203
M II+G ++A + + + +V +L+ + G P + ++ VG S +Y R K K AEK
Sbjct: 1 MTNIINGRQIAKQLNQETKTRVDKLKEE--GIIPGIVVILVGDDPASVIYTRNKQKNAEK 58
Query: 204 IGIAAEHIRLPRDITE 251
+G+ + + P+D+++
Sbjct: 59 LGMKSILRKFPKDVSQ 74
>UniRef50_UPI00006CB712 Cluster: tetrahydrofolate
dehydrogenase/cyclohydrolase, NAD(P)-binding domain;
n=1; Tetrahymena thermophila SB210|Rep: tetrahydrofolate
dehydrogenase/cyclohydrolase, NAD(P)-binding domain -
Tetrahymena thermophila SB210
Length = 377
Score = 46.4 bits (105), Expect = 4e-04
Identities = 21/78 (26%), Positives = 47/78 (60%)
Frame = +3
Query: 18 AKMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAA 197
A+ +++G +++ + +++++ R+ + EP+LAI+ VG DS Y+ +K +A
Sbjct: 25 AEQPILVNGNKISKDVLQKVKERILRVNIR----EPKLAIILVGNAADSISYVSVKQRAC 80
Query: 198 EKIGIAAEHIRLPRDITE 251
+++G+ +E I LP T+
Sbjct: 81 KRVGVQSELIHLPETTTQ 98
Score = 39.9 bits (89), Expect = 0.034
Identities = 21/83 (25%), Positives = 39/83 (46%), Gaps = 2/83 (2%)
Frame = +2
Query: 269 ITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNT--INEGRVXVGDLSG 442
+ LN+ V I+ Q+P + + V + + P KDVDGL + + + +
Sbjct: 105 VEDLNKREDVDSILTQLPFPAQISKTI--VINQIEPSKDVDGLQRCFLTQQLIWDDHNNR 162
Query: 443 XIPCTPAGCVELIXKTGVTIAGK 511
+PCTP C+ ++ + + GK
Sbjct: 163 ALPCTPQSCLHILDTHKIDVKGK 185
>UniRef50_Q8EV80 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma penetrans|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma penetrans
Length = 282
Score = 46.4 bits (105), Expect = 4e-04
Identities = 25/86 (29%), Positives = 47/86 (54%), Gaps = 1/86 (1%)
Frame = +2
Query: 257 LLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGR-VXVGD 433
L+ +I LN S+ G I+Q+P D++ + + + +KD+DGL++ R + +
Sbjct: 74 LIKQIHILNNDDSIDGYIIQLPLPK--GFDSNVICEHIDVNKDIDGLSSFAISRNLANSN 131
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
L PCT G +E++ ++ +I GK
Sbjct: 132 LFHPKPCTANGIIEILKQSNYSIEGK 157
Score = 35.1 bits (77), Expect = 0.97
Identities = 17/60 (28%), Positives = 36/60 (60%)
Frame = +3
Query: 33 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGI 212
I++ I++A +I + + + +L+ K P +AIV++ S+ Y+ +KLK A ++G+
Sbjct: 2 IVNCIDIANNILDKFKSDLEKLKKK--KIIPHMAIVKINDDAASDKYVSIKLKKAAELGV 59
>UniRef50_Q8RDM4 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Fusobacterium nucleatum|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Fusobacterium nucleatum subsp. nucleatum
Length = 283
Score = 46.4 bits (105), Expect = 4e-04
Identities = 28/85 (32%), Positives = 42/85 (49%)
Frame = +2
Query: 257 LLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDL 436
LL I LN+ V GI++ +P +A +V +++ KDVDG N G + +
Sbjct: 76 LLNLIDKLNKDTEVDGIMINLPLPPQ--INATKVLNSIKLIKDVDGFKAENLGLLFQNNE 133
Query: 437 SGXIPCTPAGCVELIXKTGVTIAGK 511
P TPAG + LI K + + GK
Sbjct: 134 GFTSPSTPAGIMALIEKYNIDLEGK 158
Score = 33.9 bits (74), Expect = 2.2
Identities = 17/73 (23%), Positives = 38/73 (52%)
Frame = +3
Query: 33 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGI 212
++ G E+A I+ ++ ++ ++ K P +A + VG S VY+ ++K+ + +GI
Sbjct: 2 LMDGKELARDIKVKIKAEIDNIK-KIHNINPMVATILVGDDPASQVYLNSQVKSYQDLGI 60
Query: 213 AAEHIRLPRDITE 251
+ +I+E
Sbjct: 61 GVQKYFFSEEISE 73
>UniRef50_Q6MI74 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Bdellovibrio bacteriovorus|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Bdellovibrio
bacteriovorus
Length = 288
Score = 46.0 bits (104), Expect = 5e-04
Identities = 31/87 (35%), Positives = 43/87 (49%)
Frame = +2
Query: 251 NKLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVG 430
N++L+K LN V GI+VQ P + D V VS +KD DGL + G G
Sbjct: 79 NQILSK---LNNDNGVDGILVQFPLPKHLSSD--EVLKLVSAEKDADGLTYESLGYFFAG 133
Query: 431 DLSGXIPCTPAGCVELIXKTGVTIAGK 511
PCTPAG +E++ + + GK
Sbjct: 134 KPL-VSPCTPAGVMEILKHYRIPVEGK 159
Score = 44.8 bits (101), Expect = 0.001
Identities = 26/76 (34%), Positives = 42/76 (55%)
Frame = +3
Query: 24 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEK 203
M I+ G EVA + L +V + + + G P+L++V VG S+VY++ K A EK
Sbjct: 1 MVLILDGKEVAKEVRASLVPRVAKFKETY-GRAPQLSVVIVGDDKASHVYVKNKKIACEK 59
Query: 204 IGIAAEHIRLPRDITE 251
IG+ + LP + T+
Sbjct: 60 IGMTSTIHTLPAETTQ 75
>UniRef50_UPI00006CCCC6 Cluster: methylenetetrahydrofolate
dehydrogenase; n=1; Tetrahymena thermophila SB210|Rep:
methylenetetrahydrofolate dehydrogenase - Tetrahymena
thermophila SB210
Length = 342
Score = 45.6 bits (103), Expect = 7e-04
Identities = 24/85 (28%), Positives = 45/85 (52%)
Frame = +2
Query: 257 LLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDL 436
+L+ I +LN + I+ Q+P S D + V + +S +KD DGL +N +
Sbjct: 94 VLSAIDNLNRKDDIDAIMAQLPLPSH--IDKNNVINMISSEKDADGLK-LNSNNLD--PK 148
Query: 437 SGXIPCTPAGCVELIXKTGVTIAGK 511
+ +PCTPA C++++ + + + K
Sbjct: 149 ANILPCTPAACLKILEEHQICLKDK 173
Score = 37.5 bits (83), Expect = 0.18
Identities = 25/83 (30%), Positives = 41/83 (49%), Gaps = 1/83 (1%)
Frame = +3
Query: 6 TVLWAKMAQIISGIEVAGSIENDLRQQVTRLRSKWS-GFEPRLAIVQVGGRXDSNVYIRM 182
T+ ++ + +G + A I + LR+++ + + +P L I+ VG S YI+
Sbjct: 9 TLRYSFSTVVFNGNKSAKKILSSLRKEIEWFQKQSDLSRKPGLGIILVGNNPASLSYIKK 68
Query: 183 KLKAAEKIGIAAEHIRLPRDITE 251
KL+A E IGI E DI E
Sbjct: 69 KLQACEAIGIRHELYHFSEDIQE 91
>UniRef50_A5IXS7 Cluster: FolD bifunctional protein; n=1; Mycoplasma
agalactiae|Rep: FolD bifunctional protein - Mycoplasma
agalactiae
Length = 286
Score = 45.2 bits (102), Expect = 0.001
Identities = 25/79 (31%), Positives = 48/79 (60%)
Frame = +3
Query: 33 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGI 212
I++G +A +L+++ + +K G +P L+I+QVG S++YI+ K+K AE++G+
Sbjct: 3 ILNGKIIAEERTVELKKEFEEI-TKLIGRQPVLSIIQVGDNPASSLYIKNKIKKAEELGV 61
Query: 213 AAEHIRLPRDITEISC*QK 269
A + DI++ S +K
Sbjct: 62 KATLYKFDEDISQNSLLKK 80
>UniRef50_Q14NV1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Spiroplasma citri|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Spiroplasma citri
Length = 286
Score = 45.2 bits (102), Expect = 0.001
Identities = 24/74 (32%), Positives = 41/74 (55%)
Frame = +3
Query: 30 QIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIG 209
+II G V+ I+ + +Q+ ++++K P L I+Q+G S YI+ K A EK+G
Sbjct: 5 KIIDGKMVSELIKAKITEQILKIKAKKQRV-PALTIIQIGNNKASTTYIKNKKIACEKVG 63
Query: 210 IAAEHIRLPRDITE 251
+ + + P ITE
Sbjct: 64 VTCKVLNYPDIITE 77
Score = 41.9 bits (94), Expect = 0.008
Identities = 24/85 (28%), Positives = 43/85 (50%)
Frame = +2
Query: 257 LLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDL 436
L+ I LN + + I+VQ+P S ++ +V + + KDVDG G + +G
Sbjct: 80 LIKIINDLNNNSKIDAILVQLPLPSH--INSEKVINTIITKKDVDGFTPKILGNLMLGHY 137
Query: 437 SGXIPCTPAGCVELIXKTGVTIAGK 511
+ +P TP G + L+ + +AG+
Sbjct: 138 N-LLPSTPKGIIALLKHYQIQLAGQ 161
>UniRef50_Q2UUX1 Cluster: RIB40 genomic DNA, SC009; n=1; Aspergillus
oryzae|Rep: RIB40 genomic DNA, SC009 - Aspergillus
oryzae
Length = 275
Score = 43.6 bits (98), Expect = 0.003
Identities = 34/99 (34%), Positives = 45/99 (45%), Gaps = 13/99 (13%)
Frame = +2
Query: 203 NWYRRRTYPLTKGHH*NKLLAK-----ITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDA 367
NW R+ + H KL K I ++N + SVHGIIV P D D +
Sbjct: 51 NWTRKTCQEIGVHFHLMKLSPKNVATYIRAINANNSVHGIIVYYPIFGDRRDD--EIRQL 108
Query: 368 VSPDKDVDGLNTINEGRV-XVGDLS-------GXIPCTP 460
V+P KDV+GLN R+ ++S IPCTP
Sbjct: 109 VAPSKDVEGLNHQTLHRISDAAEVSRPPKPGRNVIPCTP 147
>UniRef50_A0DMT9 Cluster: Chromosome undetermined scaffold_57, whole
genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_57,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 309
Score = 43.2 bits (97), Expect = 0.004
Identities = 22/84 (26%), Positives = 46/84 (54%), Gaps = 1/84 (1%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTIN-EGRVXVG 430
+++ +I SLN+ S+ GI+VQ+P +++ + +KD+D L+ N + + G
Sbjct: 81 EIVHRIKSLNQKGSIDGILVQLPLPPH--LSRLEISNEIKLNKDIDCLHMANFQNLLQNG 138
Query: 431 DLSGXIPCTPAGCVELIXKTGVTI 502
+ + IPCTPA + ++ + +
Sbjct: 139 EDNDIIPCTPAAVLHILDTQNIDV 162
Score = 31.9 bits (69), Expect = 9.0
Identities = 16/43 (37%), Positives = 22/43 (51%)
Frame = +3
Query: 123 PRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRDITE 251
P LAI+QVG S Y+R K+ E+ I E P I++
Sbjct: 37 PGLAIIQVGNNPSSLTYVRKKIALCEEHQIHHELYHFPETISQ 79
>UniRef50_A0C3Q0 Cluster: Chromosome undetermined scaffold_147,
whole genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_147,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 404
Score = 42.3 bits (95), Expect = 0.006
Identities = 25/71 (35%), Positives = 40/71 (56%), Gaps = 1/71 (1%)
Frame = +2
Query: 302 GIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXV-GDLSGXIPCTPAGCVEL 478
GI+VQ+P S H + ++ +KDVD L+ N R+ V G+L +PCTPA +++
Sbjct: 197 GILVQLPLPS-HLNKLD-IIHSIPYEKDVDCLHMHNLQRILVYGELCEMLPCTPAAVLQI 254
Query: 479 IXKTGVTIAGK 511
+ V + GK
Sbjct: 255 LDYYDVNVIGK 265
Score = 33.5 bits (73), Expect = 3.0
Identities = 23/67 (34%), Positives = 35/67 (52%)
Frame = +3
Query: 21 KMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAE 200
K+ I +G ++A +I LR +T S +P+L I VG S Y+ KLKA +
Sbjct: 115 KLKMIFNGNQLANTILKTLR--IT------SEIKPKLGICLVGDSPASKSYVNRKLKACQ 166
Query: 201 KIGIAAE 221
+I + AE
Sbjct: 167 EINVDAE 173
>UniRef50_P47259 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Mycoplasma|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma genitalium
Length = 273
Score = 41.9 bits (94), Expect = 0.008
Identities = 22/50 (44%), Positives = 32/50 (64%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNT 403
+L+ KI SLN +V GII+Q+P D + + +A++P KDVDGL T
Sbjct: 68 ELIEKIISLNHDVNVTGIILQLPVYPH--LDKNSLLEAINPLKDVDGLTT 115
>UniRef50_Q54Z91 Cluster: Methylenetetrahydrofolate dehydrogenase;
n=2; Dictyostelium discoideum|Rep:
Methylenetetrahydrofolate dehydrogenase - Dictyostelium
discoideum AX4
Length = 313
Score = 40.3 bits (90), Expect = 0.026
Identities = 28/85 (32%), Positives = 41/85 (48%), Gaps = 9/85 (10%)
Frame = +2
Query: 269 ITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRV--XVGDLSG 442
I N VHGI+V P D++ + D VSP KD++GL+T N + + + G
Sbjct: 84 IIEANNDSCVHGILVYYPVFGG-MMDSY-LQDVVSPTKDIEGLSTQNRFNLYHNIRFMDG 141
Query: 443 -------XIPCTPAGCVELIXKTGV 496
IPCTP V++I G+
Sbjct: 142 ETATKKCVIPCTPLAMVKIIDNLGI 166
>UniRef50_Q6KID0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma mobile|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma mobile
Length = 280
Score = 40.3 bits (90), Expect = 0.026
Identities = 26/76 (34%), Positives = 38/76 (50%)
Frame = +2
Query: 284 ESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGXIPCTPA 463
ES HG+IVQ+P D ++ ++V KD+DGL+ N + G S P T
Sbjct: 80 ESKISHGLIVQLPLPLQF--DQSKILNSVPITKDIDGLSEKNSKNLYSGK-SCIQPATAR 136
Query: 464 GCVELIXKTGVTIAGK 511
G ++LI + TI K
Sbjct: 137 GIIDLIKEYNFTIKDK 152
Score = 39.5 bits (88), Expect = 0.045
Identities = 18/44 (40%), Positives = 27/44 (61%)
Frame = +3
Query: 120 EPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRDITE 251
+P IVQVG SN YI+ K+ A +IG+ + I++P I+E
Sbjct: 27 KPVFTIVQVGNLFSSNKYIKTKMDKALEIGVVSRLIKIPESISE 70
>UniRef50_Q979W3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermoplasma|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermoplasma volcanium
Length = 281
Score = 39.1 bits (87), Expect = 0.060
Identities = 18/60 (30%), Positives = 35/60 (58%)
Frame = +3
Query: 30 QIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIG 209
+++ G E+A +L++++ ++ G PRL ++QVG + +Y R K+K +KIG
Sbjct: 4 KLLKGEEIAEKKAEELKERIEKM-----GVSPRLVLLQVGNYSAATIYARAKIKRGKKIG 58
Score = 34.7 bits (76), Expect = 1.3
Identities = 20/80 (25%), Positives = 40/80 (50%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+L+ +I L+ V+GI+V+ P D + + ++ KDVD L+ N+G + + +
Sbjct: 73 ELVRRIEELSADKDVNGIMVENPLPK--TIDYYDIVKSIPYYKDVDALSPYNQGSIAI-N 129
Query: 434 LSGXIPCTPAGCVELIXKTG 493
+P T V+++ G
Sbjct: 130 REFLVPATAMAVVDILKYYG 149
>UniRef50_Q057D7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Enterobacteriaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Buchnera aphidicola subsp. Cinara cedri
Length = 284
Score = 39.1 bits (87), Expect = 0.060
Identities = 23/85 (27%), Positives = 42/85 (49%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+L+ I LN++ + GI++Q+P + ++ ++ P KDVDG + N G + +
Sbjct: 78 ELINLIKKLNKNKCIDGILIQLPLPIK--INYLKIITSIDPKKDVDGFHPYNLGSLCQNN 135
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAG 508
CT G + L+ K + I G
Sbjct: 136 -PQFRSCTSKGVITLLKKYKINIHG 159
>UniRef50_Q8KEH0 Cluster: Methylenetetrahydrofolate dehydrogenase;
n=1; Chlorobaculum tepidum|Rep:
Methylenetetrahydrofolate dehydrogenase - Chlorobium
tepidum
Length = 296
Score = 37.1 bits (82), Expect = 0.24
Identities = 25/84 (29%), Positives = 39/84 (46%), Gaps = 8/84 (9%)
Frame = +2
Query: 263 AKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD--- 433
A + + N +VHGI V P D DA + D +SP KDV+GL+ ++ +
Sbjct: 71 ATLEAANRDSAVHGIFVYYPIWGDKR-DAE-LRDLISPHKDVEGLSPHWIKKLYANERFD 128
Query: 434 -----LSGXIPCTPAGCVELIXKT 490
+PCTP ++L+ T
Sbjct: 129 DTERRFKSILPCTPLAIIKLLEVT 152
>UniRef50_Q4VDG8 Cluster: Putative methylene tetrahydrofolate
dehydrogenase; n=1; Hyaloperonospora parasitica|Rep:
Putative methylene tetrahydrofolate dehydrogenase -
Hyaloperonospora parasitica
Length = 328
Score = 36.7 bits (81), Expect = 0.32
Identities = 28/93 (30%), Positives = 40/93 (43%), Gaps = 13/93 (13%)
Frame = +2
Query: 257 LLAKITSLNESPSVHGIIVQMPXXSDH-----AXDAHRVTDAVSPDKDVDGLNTINEGRV 421
LLA + NE P VHGI+V P + D++S KDV+GL G +
Sbjct: 86 LLAALQQANEDPDVHGILVYYPCFGTFPSFFGGTMDDFLRDSISIKKDVEGLGQFYRGNL 145
Query: 422 -----XVGD---LSGXIPCTPAGCVELIXKTGV 496
V D +PCTP V+++ G+
Sbjct: 146 YRNIRYVDDEKTQKCVLPCTPLAIVKILEHLGI 178
>UniRef50_A7AXK7 Cluster: Putative uncharacterized protein; n=1;
Ruminococcus gnavus ATCC 29149|Rep: Putative
uncharacterized protein - Ruminococcus gnavus ATCC 29149
Length = 276
Score = 36.3 bits (80), Expect = 0.42
Identities = 19/62 (30%), Positives = 34/62 (54%)
Frame = +3
Query: 66 ENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRDI 245
+ +L++++ L K P LA++Q+ SN YI+ K K ++IGI H+ + +
Sbjct: 16 KKELKEEIKHLDKK-----PVLAVIQIDDDQASNSYIKGKQKDCDEIGIEMRHVNIYSNT 70
Query: 246 TE 251
TE
Sbjct: 71 TE 72
>UniRef50_UPI0000D9D4E1 Cluster: PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor; n=2; Catarrhini|Rep: PREDICTED:
similar to Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor -
Macaca mulatta
Length = 111
Score = 35.1 bits (77), Expect = 0.97
Identities = 19/62 (30%), Positives = 35/62 (56%)
Frame = +3
Query: 27 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
A +ISG ++A I+ ++RQ+V + P L+++ VG S+ Y+ K +AA +
Sbjct: 37 AVVISGRKLAQEIKQEVRQEVEEWVAS-GNKRPHLSVILVGENPASHSYVLNKTRAAADV 95
Query: 207 GI 212
G+
Sbjct: 96 GM 97
>UniRef50_A6NP56 Cluster: Uncharacterized protein ENSP00000372121;
n=5; Eutheria|Rep: Uncharacterized protein
ENSP00000372121 - Homo sapiens (Human)
Length = 200
Score = 35.1 bits (77), Expect = 0.97
Identities = 20/65 (30%), Positives = 37/65 (56%)
Frame = +3
Query: 27 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
A +ISG ++A I+ ++RQ+V + P L+++ VG S+ Y+ K +AA +
Sbjct: 37 AVVISGRKLAQQIKQEVRQEVEEWVAS-GDKRPHLSMILVGESSASHSYVLNKTRAAADV 95
Query: 207 GIAAE 221
GI ++
Sbjct: 96 GINSD 100
>UniRef50_Q9X288 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Thermotogaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermotoga maritima
Length = 271
Score = 34.7 bits (76), Expect = 1.3
Identities = 22/86 (25%), Positives = 41/86 (47%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
++++ + L SV+G+ V P D + +V +KDV+G+N N G + + D
Sbjct: 67 EIVSTLKKLGSDESVNGVFVARPFPL--GLDEKEILSSVPVEKDVEGVNPANLG-LLLYD 123
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
PCT V ++ + ++GK
Sbjct: 124 EEIFPPCTAEAAVRILERE-TNLSGK 148
Score = 32.7 bits (71), Expect = 5.2
Identities = 22/66 (33%), Positives = 36/66 (54%), Gaps = 1/66 (1%)
Frame = +3
Query: 51 VAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIR 230
+A SIE +++V +L GF P+L V + Y++ + K AEK+GIA E +
Sbjct: 8 IARSIEERTKERVEKL-----GFTPKLVSVACTDDPSALSYLKSQRKKAEKLGIAFEIMN 62
Query: 231 L-PRDI 245
+ P +I
Sbjct: 63 VSPEEI 68
>UniRef50_Q9RW02 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Deinococcus|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Deinococcus radiodurans
Length = 299
Score = 34.7 bits (76), Expect = 1.3
Identities = 18/65 (27%), Positives = 34/65 (52%), Gaps = 1/65 (1%)
Frame = +2
Query: 269 ITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVG-DLSGX 445
+ L+ P+VHGI++++P + DA ++ KD++GL+ N + G +
Sbjct: 93 LRELSADPAVHGIVLELPLAA--GLDADAALLHIAARKDIEGLSPANLALIAAGREPEAL 150
Query: 446 IPCTP 460
+P TP
Sbjct: 151 LPPTP 155
Score = 31.9 bits (69), Expect = 9.0
Identities = 16/45 (35%), Positives = 24/45 (53%)
Frame = +3
Query: 117 FEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRDITE 251
FEP+L V S VY++ K K A+K+G+A + L T+
Sbjct: 42 FEPQLVSVLASDDEASQVYVQSKAKRAKKLGVAFRVVDLGAAATQ 86
>UniRef50_A6FY71 Cluster: Histone deacetylase superfamily protein;
n=1; Plesiocystis pacifica SIR-1|Rep: Histone
deacetylase superfamily protein - Plesiocystis pacifica
SIR-1
Length = 623
Score = 33.1 bits (72), Expect = 3.9
Identities = 25/72 (34%), Positives = 36/72 (50%), Gaps = 5/72 (6%)
Frame = +3
Query: 42 GIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDS-NVYIRMKLKAAEKIGIAA 218
G +E L + R + G+EPR+ +V GGR DS +R+ +A + G AA
Sbjct: 383 GYYTLSGVELGLERYGLLARLRDLGYEPRVEMVVDGGRRDSAGDTVRVWGRAQTREGSAA 442
Query: 219 EHI----RLPRD 242
EH+ RL RD
Sbjct: 443 EHLLVEARLSRD 454
>UniRef50_Q98QV3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma pulmonis|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma pulmonis
Length = 272
Score = 32.7 bits (71), Expect = 5.2
Identities = 17/56 (30%), Positives = 34/56 (60%), Gaps = 3/56 (5%)
Frame = +3
Query: 63 IENDLRQ-QVTRLRSKWSGFEPRL--AIVQVGGRXDSNVYIRMKLKAAEKIGIAAE 221
+ N+L Q + L+ K+S + ++ AIV +G S +Y++ K++ A+ IG+ A+
Sbjct: 6 LSNELVQIKRAELKEKFSKLDQKVKFAIVLIGDNASSKIYVKKKIEFAQDIGVEAK 61
>UniRef50_Q0A579 Cluster: Putative uncharacterized protein; n=1;
Alkalilimnicola ehrlichei MLHE-1|Rep: Putative
uncharacterized protein - Alkalilimnicola ehrlichei
(strain MLHE-1)
Length = 403
Score = 32.3 bits (70), Expect = 6.8
Identities = 20/63 (31%), Positives = 33/63 (52%)
Frame = +3
Query: 54 AGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRL 233
AG LR+Q+ LR++ GFE L ++G R ++N ++ +AA +A +R
Sbjct: 139 AGDALGTLREQLDELRARQGGFEEGLE--RLGARAEANRENWIRSEAAYLATVAVHRMRF 196
Query: 234 PRD 242
RD
Sbjct: 197 HRD 199
>UniRef50_A2DM64 Cluster: Putative uncharacterized protein; n=1;
Trichomonas vaginalis G3|Rep: Putative uncharacterized
protein - Trichomonas vaginalis G3
Length = 767
Score = 32.3 bits (70), Expect = 6.8
Identities = 15/32 (46%), Positives = 23/32 (71%)
Frame = +3
Query: 159 DSNVYIRMKLKAAEKIGIAAEHIRLPRDITEI 254
DS+V I++KLKAAE + ++A+ +L D EI
Sbjct: 381 DSDVSIKLKLKAAESLAVSAKESKLSPDNFEI 412
>UniRef50_Q5KEZ0 Cluster: Methylenetetrahydrofolate dehydrogenase
(NAD+), putative; n=1; Filobasidiella neoformans|Rep:
Methylenetetrahydrofolate dehydrogenase (NAD+), putative
- Cryptococcus neoformans (Filobasidiella neoformans)
Length = 367
Score = 31.9 bits (69), Expect = 9.0
Identities = 18/44 (40%), Positives = 23/44 (52%)
Frame = +2
Query: 269 ITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLN 400
I NE P V G++V P D + + VSP KDV+GLN
Sbjct: 90 ILEANEDPEVDGMMVYYPIYGGRQ-DQY-LQSVVSPQKDVEGLN 131
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 440,585,762
Number of Sequences: 1657284
Number of extensions: 7316423
Number of successful extensions: 15866
Number of sequences better than 10.0: 102
Number of HSP's better than 10.0 without gapping: 15324
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 15758
length of database: 575,637,011
effective HSP length: 95
effective length of database: 418,195,031
effective search space used: 32201017387
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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