Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fbS20034
(519 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
J04031-1|AAA59574.1| 935|Homo sapiens MTHFD protein. 99 5e-21
BC050420-1|AAH50420.1| 935|Homo sapiens methylenetetrahydrofola... 99 5e-21
BC009806-1|AAH09806.1| 935|Homo sapiens methylenetetrahydrofola... 99 5e-21
X16396-1|CAA34431.1| 344|Homo sapiens protein ( Human mRNA for ... 71 3e-12
BC017054-1|AAH17054.2| 350|Homo sapiens methylenetetrahydrofola... 71 3e-12
BC015062-1|AAH15062.1| 248|Homo sapiens methylenetetrahydrofola... 71 3e-12
BC001548-1|AAH01548.1| 344|Homo sapiens methylene tetrahydrofol... 71 3e-12
AK223041-1|BAD96761.1| 344|Homo sapiens methylene tetrahydrofol... 71 3e-12
AK222826-1|BAD96546.1| 344|Homo sapiens methylene tetrahydrofol... 71 3e-12
AC073263-5|AAX93061.1| 344|Homo sapiens unknown protein. 71 3e-12
BC032771-1|AAH32771.1| 146|Homo sapiens MTHFD2L protein protein. 57 4e-08
BC110319-1|AAI10320.1| 900|Homo sapiens MTHFD1L protein protein. 51 2e-06
AY374131-1|AAQ82697.1| 275|Homo sapiens truncated C1-tetrahydro... 51 2e-06
AY374130-1|AAQ82696.1| 978|Homo sapiens C1-tetrahydrofolate syn... 51 2e-06
AL133260-2|CAI95678.1| 978|Homo sapiens methylenetetrahydrofola... 51 2e-06
AL117452-1|CAB55934.1| 917|Homo sapiens hypothetical protein pr... 51 2e-06
AL049694-3|CAI95774.1| 978|Homo sapiens methylenetetrahydrofola... 51 2e-06
AL035086-7|CAI42794.1| 978|Homo sapiens methylenetetrahydrofola... 51 2e-06
AL035086-6|CAI42793.1| 114|Homo sapiens methylenetetrahydrofola... 51 2e-06
AB127387-1|BAD93193.1| 978|Homo sapiens mitochondrial C1-tetrah... 51 2e-06
AL049694-4|CAI95775.1| 331|Homo sapiens methylenetetrahydrofola... 47 5e-05
AL035086-8|CAI42795.1| 331|Homo sapiens methylenetetrahydrofola... 47 5e-05
AK023167-1|BAB14441.1| 236|Homo sapiens ohydrolase (EC 1.5.1.15... 45 1e-04
BC037529-1|AAH37529.2| 106|Homo sapiens MTHFD2L protein protein. 42 0.001
AL035086-4|CAI42792.1| 120|Homo sapiens methylenetetrahydrofola... 42 0.001
AL035086-5|CAI42791.1| 120|Homo sapiens methylenetetrahydrofola... 38 0.028
>J04031-1|AAA59574.1| 935|Homo sapiens MTHFD protein.
Length = 935
Score = 99 bits (238), Expect = 5e-21
Identities = 45/88 (51%), Positives = 66/88 (75%), Gaps = 1/88 (1%)
Frame = +2
Query: 251 NKLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVG 430
++++ ITSLNE +VHG +VQ+P S+++ + V +A++P+KDVDGL +IN GR+ G
Sbjct: 79 SEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKDVDGLTSINAGRLARG 138
Query: 431 DLSG-XIPCTPAGCVELIXKTGVTIAGK 511
DL+ IPCTP GC+ELI +TGV IAG+
Sbjct: 139 DLNDCFIPCTPKGCLELIKETGVPIAGR 166
Score = 90.6 bits (215), Expect = 3e-18
Identities = 43/75 (57%), Positives = 57/75 (76%)
Frame = +3
Query: 27 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
A+I++G E++ I L+ QVT+L+ + GF PRLAI+QVG R DSN+YI +KLKAAE+I
Sbjct: 4 AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63
Query: 207 GIAAEHIRLPRDITE 251
GI A HI+LPR TE
Sbjct: 64 GIKATHIKLPRTTTE 78
>BC050420-1|AAH50420.1| 935|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1, methenyltetrahydro
protein.
Length = 935
Score = 99 bits (238), Expect = 5e-21
Identities = 45/88 (51%), Positives = 66/88 (75%), Gaps = 1/88 (1%)
Frame = +2
Query: 251 NKLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVG 430
++++ ITSLNE +VHG +VQ+P S+++ + V +A++P+KDVDGL +IN GR+ G
Sbjct: 79 SEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKDVDGLTSINAGRLARG 138
Query: 431 DLSG-XIPCTPAGCVELIXKTGVTIAGK 511
DL+ IPCTP GC+ELI +TGV IAG+
Sbjct: 139 DLNDCFIPCTPKGCLELIKETGVPIAGR 166
Score = 90.6 bits (215), Expect = 3e-18
Identities = 43/75 (57%), Positives = 57/75 (76%)
Frame = +3
Query: 27 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
A+I++G E++ I L+ QVT+L+ + GF PRLAI+QVG R DSN+YI +KLKAAE+I
Sbjct: 4 AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63
Query: 207 GIAAEHIRLPRDITE 251
GI A HI+LPR TE
Sbjct: 64 GIKATHIKLPRTTTE 78
>BC009806-1|AAH09806.1| 935|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1, methenyltetrahydro
protein.
Length = 935
Score = 99 bits (238), Expect = 5e-21
Identities = 45/88 (51%), Positives = 66/88 (75%), Gaps = 1/88 (1%)
Frame = +2
Query: 251 NKLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVG 430
++++ ITSLNE +VHG +VQ+P S+++ + V +A++P+KDVDGL +IN GR+ G
Sbjct: 79 SEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKDVDGLTSINAGRLARG 138
Query: 431 DLSG-XIPCTPAGCVELIXKTGVTIAGK 511
DL+ IPCTP GC+ELI +TGV IAG+
Sbjct: 139 DLNDCFIPCTPKGCLELIKETGVPIAGR 166
Score = 90.6 bits (215), Expect = 3e-18
Identities = 43/75 (57%), Positives = 57/75 (76%)
Frame = +3
Query: 27 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
A+I++G E++ I L+ QVT+L+ + GF PRLAI+QVG R DSN+YI +KLKAAE+I
Sbjct: 4 AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63
Query: 207 GIAAEHIRLPRDITE 251
GI A HI+LPR TE
Sbjct: 64 GIKATHIKLPRTTTE 78
>X16396-1|CAA34431.1| 344|Homo sapiens protein ( Human mRNA for
NAD-dependent methylene tetrahydrofolate dehydrogenase
cyclohydrolase (EC 1.5.1.15). ).
Length = 344
Score = 70.5 bits (165), Expect = 3e-12
Identities = 38/86 (44%), Positives = 53/86 (61%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+LL I LN +V G++VQ+P +H D R+ +AVSPDKDVDG + IN GR+ + D
Sbjct: 106 ELLNLINKLNNDDNVDGLLVQLPLP-EHI-DERRICNAVSPDKDVDGFHVINVGRMCL-D 162
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
+P TP G E+I +TG+ GK
Sbjct: 163 QYSMLPATPWGVWEIIKRTGIPTLGK 188
Score = 43.6 bits (98), Expect = 4e-04
Identities = 25/75 (33%), Positives = 42/75 (56%)
Frame = +3
Query: 27 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
A +ISG ++A I+ ++RQ+V + P L+++ VG S+ Y+ K +AA +
Sbjct: 31 AVVISGRKLAQQIKQEVRQEVEEWVAS-GNKRPHLSVILVGENPASHSYVLNKTRAAAVV 89
Query: 207 GIAAEHIRLPRDITE 251
GI +E I P I+E
Sbjct: 90 GINSETIMKPASISE 104
>BC017054-1|AAH17054.2| 350|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 2, methenyltetrahydro
protein.
Length = 350
Score = 70.5 bits (165), Expect = 3e-12
Identities = 38/86 (44%), Positives = 53/86 (61%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+LL I LN +V G++VQ+P +H D R+ +AVSPDKDVDG + IN GR+ + D
Sbjct: 112 ELLNLINKLNNDDNVDGLLVQLPLP-EHI-DERRICNAVSPDKDVDGFHVINVGRMCL-D 168
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
+P TP G E+I +TG+ GK
Sbjct: 169 QYSMLPATPWGVWEIIKRTGIPTLGK 194
Score = 43.6 bits (98), Expect = 4e-04
Identities = 25/75 (33%), Positives = 42/75 (56%)
Frame = +3
Query: 27 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
A +ISG ++A I+ ++RQ+V + P L+++ VG S+ Y+ K +AA +
Sbjct: 37 AVVISGRKLAQQIKQEVRQEVEEWVAS-GNKRPHLSVILVGENPASHSYVLNKTRAAAVV 95
Query: 207 GIAAEHIRLPRDITE 251
GI +E I P I+E
Sbjct: 96 GINSETIMKPASISE 110
>BC015062-1|AAH15062.1| 248|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 2, methenyltetrahydro
protein.
Length = 248
Score = 70.5 bits (165), Expect = 3e-12
Identities = 38/86 (44%), Positives = 53/86 (61%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+LL I LN +V G++VQ+P +H D R+ +AVSPDKDVDG + IN GR+ + D
Sbjct: 10 ELLNLINKLNNDDNVDGLLVQLPLP-EHI-DERRICNAVSPDKDVDGFHVINVGRMCL-D 66
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
+P TP G E+I +TG+ GK
Sbjct: 67 QYSMLPATPWGVWEIIKRTGIPTLGK 92
>BC001548-1|AAH01548.1| 344|Homo sapiens methylene tetrahydrofolate
dehydrogenase 2, precursor protein.
Length = 344
Score = 70.5 bits (165), Expect = 3e-12
Identities = 38/86 (44%), Positives = 53/86 (61%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+LL I LN +V G++VQ+P +H D R+ +AVSPDKDVDG + IN GR+ + D
Sbjct: 106 ELLNLINKLNNDDNVDGLLVQLPLP-EHI-DERRICNAVSPDKDVDGFHVINVGRMCL-D 162
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
+P TP G E+I +TG+ GK
Sbjct: 163 QYSMLPATPWGVWEIIKRTGIPTLGK 188
Score = 43.6 bits (98), Expect = 4e-04
Identities = 25/75 (33%), Positives = 42/75 (56%)
Frame = +3
Query: 27 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
A +ISG ++A I+ ++RQ+V + P L+++ VG S+ Y+ K +AA +
Sbjct: 31 AVVISGRKLAQQIKQEVRQEVEEWVAS-GNKRPHLSVILVGENPASHSYVLNKTRAAAVV 89
Query: 207 GIAAEHIRLPRDITE 251
GI +E I P I+E
Sbjct: 90 GINSETIMKPASISE 104
>AK223041-1|BAD96761.1| 344|Homo sapiens methylene tetrahydrofolate
dehydrogenase 2 precursor variant protein.
Length = 344
Score = 70.5 bits (165), Expect = 3e-12
Identities = 38/86 (44%), Positives = 53/86 (61%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+LL I LN +V G++VQ+P +H D R+ +AVSPDKDVDG + IN GR+ + D
Sbjct: 106 ELLNLINKLNNDDNVDGLLVQLPLP-EHI-DERRICNAVSPDKDVDGFHVINVGRMCL-D 162
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
+P TP G E+I +TG+ GK
Sbjct: 163 QYSMLPATPWGVWEIIKRTGIPTLGK 188
Score = 41.9 bits (94), Expect = 0.001
Identities = 25/75 (33%), Positives = 41/75 (54%)
Frame = +3
Query: 27 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
A +ISG ++A I+ ++RQ+V + P L+++ VG S+ Y+ K +AA
Sbjct: 31 AVVISGRKLAQQIKQEVRQEVEEWVAS-GNKRPHLSVILVGENPASHSYVLNKTRAAAVA 89
Query: 207 GIAAEHIRLPRDITE 251
GI +E I P I+E
Sbjct: 90 GINSETIMKPASISE 104
>AK222826-1|BAD96546.1| 344|Homo sapiens methylene tetrahydrofolate
dehydrogenase 2 precursor variant protein.
Length = 344
Score = 70.5 bits (165), Expect = 3e-12
Identities = 38/86 (44%), Positives = 53/86 (61%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+LL I LN +V G++VQ+P +H D R+ +AVSPDKDVDG + IN GR+ + D
Sbjct: 106 ELLNLINKLNNDDNVDGLLVQLPLP-EHI-DERRICNAVSPDKDVDGFHVINVGRMCL-D 162
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
+P TP G E+I +TG+ GK
Sbjct: 163 QYSMLPATPWGVWEIIKRTGIPTLGK 188
Score = 41.9 bits (94), Expect = 0.001
Identities = 24/75 (32%), Positives = 41/75 (54%)
Frame = +3
Query: 27 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
A +ISG ++A I+ ++RQ+V + P L+++ G S+ Y+ K +AA +
Sbjct: 31 AVVISGRKLAQQIKQEVRQEVEEWVAS-GNKRPHLSVILAGENPASHSYVLNKTRAAAVV 89
Query: 207 GIAAEHIRLPRDITE 251
GI +E I P I+E
Sbjct: 90 GINSETIMKPASISE 104
>AC073263-5|AAX93061.1| 344|Homo sapiens unknown protein.
Length = 344
Score = 70.5 bits (165), Expect = 3e-12
Identities = 38/86 (44%), Positives = 53/86 (61%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+LL I LN +V G++VQ+P +H D R+ +AVSPDKDVDG + IN GR+ + D
Sbjct: 106 ELLNLINKLNNDDNVDGLLVQLPLP-EHI-DERRICNAVSPDKDVDGFHVINVGRMCL-D 162
Query: 434 LSGXIPCTPAGCVELIXKTGVTIAGK 511
+P TP G E+I +TG+ GK
Sbjct: 163 QYSMLPATPWGVWEIIKRTGIPTLGK 188
Score = 43.6 bits (98), Expect = 4e-04
Identities = 25/75 (33%), Positives = 42/75 (56%)
Frame = +3
Query: 27 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKI 206
A +ISG ++A I+ ++RQ+V + P L+++ VG S+ Y+ K +AA +
Sbjct: 31 AVVISGRKLAQQIKQEVRQEVEEWVAS-GNKRPHLSVILVGENPASHSYVLNKTRAAAVV 89
Query: 207 GIAAEHIRLPRDITE 251
GI +E I P I+E
Sbjct: 90 GINSETIMKPASISE 104
>BC032771-1|AAH32771.1| 146|Homo sapiens MTHFD2L protein protein.
Length = 146
Score = 56.8 bits (131), Expect = 4e-08
Identities = 30/74 (40%), Positives = 44/74 (59%)
Frame = +2
Query: 290 PSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGXIPCTPAGC 469
P V GI+VQ+P DH D + + ++P+KDVDG + IN GR+ + D IP T +
Sbjct: 3 PRVSGILVQLPLP-DHV-DERTICNGIAPEKDVDGFHIINIGRLCL-DQHSLIPATASAV 59
Query: 470 VELIXKTGVTIAGK 511
E+I +TG+ GK
Sbjct: 60 WEIIKRTGIQTFGK 73
>BC110319-1|AAI10320.1| 900|Homo sapiens MTHFD1L protein protein.
Length = 900
Score = 51.2 bits (117), Expect = 2e-06
Identities = 29/87 (33%), Positives = 52/87 (59%), Gaps = 1/87 (1%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+++ +I +NE VHG+ +Q+ S++ +++V +A+ P+KDVDG+ IN G++ GD
Sbjct: 61 EIIDEILKINEDTRVHGLALQI---SENLF-SNKVLNALKPEKDVDGVTDINLGKLVRGD 116
Query: 434 LSGXIPCTPA-GCVELIXKTGVTIAGK 511
A +EL+ K+GV + GK
Sbjct: 117 AHECFVSPVAKAVIELLEKSGVNLDGK 143
Score = 35.1 bits (77), Expect = 0.15
Identities = 20/58 (34%), Positives = 32/58 (55%)
Frame = +3
Query: 78 RQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRDITE 251
++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP D +E
Sbjct: 5 KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPDSSE 59
>AY374131-1|AAQ82697.1| 275|Homo sapiens truncated
C1-tetrahydrofolate synthase protein.
Length = 275
Score = 51.2 bits (117), Expect = 2e-06
Identities = 29/87 (33%), Positives = 52/87 (59%), Gaps = 1/87 (1%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+++ +I +NE VHG+ +Q+ S++ +++V +A+ P+KDVDG+ IN G++ GD
Sbjct: 139 EIIDEILKINEDTRVHGLALQI---SENLF-SNKVLNALKPEKDVDGVTDINLGKLVRGD 194
Query: 434 LSGXIPCTPA-GCVELIXKTGVTIAGK 511
A +EL+ K+GV + GK
Sbjct: 195 AHECFVSPVAKAVIELLEKSGVNLDGK 221
Score = 35.5 bits (78), Expect = 0.11
Identities = 22/63 (34%), Positives = 35/63 (55%)
Frame = +3
Query: 63 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRD 242
I+N ++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP D
Sbjct: 79 IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 134
Query: 243 ITE 251
+E
Sbjct: 135 SSE 137
>AY374130-1|AAQ82696.1| 978|Homo sapiens C1-tetrahydrofolate
synthase protein.
Length = 978
Score = 51.2 bits (117), Expect = 2e-06
Identities = 29/87 (33%), Positives = 52/87 (59%), Gaps = 1/87 (1%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+++ +I +NE VHG+ +Q+ S++ +++V +A+ P+KDVDG+ IN G++ GD
Sbjct: 139 EIIDEILKINEDTRVHGLALQI---SENLF-SNKVLNALKPEKDVDGVTDINLGKLVRGD 194
Query: 434 LSGXIPCTPA-GCVELIXKTGVTIAGK 511
A +EL+ K+GV + GK
Sbjct: 195 AHECFVSPVAKAVIELLEKSGVNLDGK 221
Score = 35.5 bits (78), Expect = 0.11
Identities = 22/63 (34%), Positives = 35/63 (55%)
Frame = +3
Query: 63 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRD 242
I+N ++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP D
Sbjct: 79 IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 134
Query: 243 ITE 251
+E
Sbjct: 135 SSE 137
>AL133260-2|CAI95678.1| 978|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 978
Score = 51.2 bits (117), Expect = 2e-06
Identities = 29/87 (33%), Positives = 52/87 (59%), Gaps = 1/87 (1%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+++ +I +NE VHG+ +Q+ S++ +++V +A+ P+KDVDG+ IN G++ GD
Sbjct: 139 EIIDEILKINEDTRVHGLALQI---SENLF-SNKVLNALKPEKDVDGVTDINLGKLVRGD 194
Query: 434 LSGXIPCTPA-GCVELIXKTGVTIAGK 511
A +EL+ K+GV + GK
Sbjct: 195 AHECFVSPVAKAVIELLEKSGVNLDGK 221
Score = 35.5 bits (78), Expect = 0.11
Identities = 22/63 (34%), Positives = 35/63 (55%)
Frame = +3
Query: 63 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRD 242
I+N ++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP D
Sbjct: 79 IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 134
Query: 243 ITE 251
+E
Sbjct: 135 SSE 137
>AL117452-1|CAB55934.1| 917|Homo sapiens hypothetical protein
protein.
Length = 917
Score = 51.2 bits (117), Expect = 2e-06
Identities = 29/87 (33%), Positives = 52/87 (59%), Gaps = 1/87 (1%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+++ +I +NE VHG+ +Q+ S++ +++V +A+ P+KDVDG+ IN G++ GD
Sbjct: 78 EIIDEILKINEDTRVHGLALQI---SENLF-SNKVLNALKPEKDVDGVTDINLGKLVRGD 133
Query: 434 LSGXIPCTPA-GCVELIXKTGVTIAGK 511
A +EL+ K+GV + GK
Sbjct: 134 AHECFVSPVAKAVIELLEKSGVNLDGK 160
Score = 35.5 bits (78), Expect = 0.11
Identities = 22/63 (34%), Positives = 35/63 (55%)
Frame = +3
Query: 63 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRD 242
I+N ++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP D
Sbjct: 18 IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 73
Query: 243 ITE 251
+E
Sbjct: 74 SSE 76
>AL049694-3|CAI95774.1| 978|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 978
Score = 51.2 bits (117), Expect = 2e-06
Identities = 29/87 (33%), Positives = 52/87 (59%), Gaps = 1/87 (1%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+++ +I +NE VHG+ +Q+ S++ +++V +A+ P+KDVDG+ IN G++ GD
Sbjct: 139 EIIDEILKINEDTRVHGLALQI---SENLF-SNKVLNALKPEKDVDGVTDINLGKLVRGD 194
Query: 434 LSGXIPCTPA-GCVELIXKTGVTIAGK 511
A +EL+ K+GV + GK
Sbjct: 195 AHECFVSPVAKAVIELLEKSGVNLDGK 221
Score = 35.5 bits (78), Expect = 0.11
Identities = 22/63 (34%), Positives = 35/63 (55%)
Frame = +3
Query: 63 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRD 242
I+N ++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP D
Sbjct: 79 IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 134
Query: 243 ITE 251
+E
Sbjct: 135 SSE 137
>AL035086-7|CAI42794.1| 978|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 978
Score = 51.2 bits (117), Expect = 2e-06
Identities = 29/87 (33%), Positives = 52/87 (59%), Gaps = 1/87 (1%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+++ +I +NE VHG+ +Q+ S++ +++V +A+ P+KDVDG+ IN G++ GD
Sbjct: 139 EIIDEILKINEDTRVHGLALQI---SENLF-SNKVLNALKPEKDVDGVTDINLGKLVRGD 194
Query: 434 LSGXIPCTPA-GCVELIXKTGVTIAGK 511
A +EL+ K+GV + GK
Sbjct: 195 AHECFVSPVAKAVIELLEKSGVNLDGK 221
Score = 35.5 bits (78), Expect = 0.11
Identities = 22/63 (34%), Positives = 35/63 (55%)
Frame = +3
Query: 63 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRD 242
I+N ++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP D
Sbjct: 79 IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 134
Query: 243 ITE 251
+E
Sbjct: 135 SSE 137
>AL035086-6|CAI42793.1| 114|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 114
Score = 51.2 bits (117), Expect = 2e-06
Identities = 29/87 (33%), Positives = 52/87 (59%), Gaps = 1/87 (1%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+++ +I +NE VHG+ +Q+ S++ +++V +A+ P+KDVDG+ IN G++ GD
Sbjct: 29 EIIDEILKINEDTRVHGLALQI---SENLF-SNKVLNALKPEKDVDGVTDINLGKLVRGD 84
Query: 434 LSGXIPCTPA-GCVELIXKTGVTIAGK 511
A +EL+ K+GV + GK
Sbjct: 85 AHECFVSPVAKAVIELLEKSGVNLDGK 111
>AB127387-1|BAD93193.1| 978|Homo sapiens mitochondrial
C1-tetrahydrofolate synthetase protein.
Length = 978
Score = 51.2 bits (117), Expect = 2e-06
Identities = 29/87 (33%), Positives = 52/87 (59%), Gaps = 1/87 (1%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+++ +I +NE VHG+ +Q+ S++ +++V +A+ P+KDVDG+ IN G++ GD
Sbjct: 139 EIIDEILKINEDTRVHGLALQI---SENLF-SNKVLNALKPEKDVDGVTDINLGKLVRGD 194
Query: 434 LSGXIPCTPA-GCVELIXKTGVTIAGK 511
A +EL+ K+GV + GK
Sbjct: 195 AHECFVSPVAKAVIELLEKSGVNLDGK 221
Score = 35.5 bits (78), Expect = 0.11
Identities = 22/63 (34%), Positives = 35/63 (55%)
Frame = +3
Query: 63 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRD 242
I+N ++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP D
Sbjct: 79 IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 134
Query: 243 ITE 251
+E
Sbjct: 135 SSE 137
>AL049694-4|CAI95775.1| 331|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 331
Score = 46.8 bits (106), Expect = 5e-05
Identities = 29/88 (32%), Positives = 52/88 (59%), Gaps = 2/88 (2%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+++ +I +NE VHG+ +Q+ S++ +++V +A+ P+KDVDG+ IN G++ GD
Sbjct: 98 EIIDEILKINEDTRVHGLALQI---SENLF-SNKVLNALKPEKDVDGVTDINLGKLVRGD 153
Query: 434 LSGXIPCTPA-GCVELIXKT-GVTIAGK 511
A +EL+ K+ GV + GK
Sbjct: 154 AHECFVSPVAKAVIELLEKSVGVNLDGK 181
Score = 35.5 bits (78), Expect = 0.11
Identities = 22/63 (34%), Positives = 35/63 (55%)
Frame = +3
Query: 63 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRD 242
I+N ++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP D
Sbjct: 38 IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 93
Query: 243 ITE 251
+E
Sbjct: 94 SSE 96
>AL035086-8|CAI42795.1| 331|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 331
Score = 46.8 bits (106), Expect = 5e-05
Identities = 29/88 (32%), Positives = 52/88 (59%), Gaps = 2/88 (2%)
Frame = +2
Query: 254 KLLAKITSLNESPSVHGIIVQMPXXSDHAXDAHRVTDAVSPDKDVDGLNTINEGRVXVGD 433
+++ +I +NE VHG+ +Q+ S++ +++V +A+ P+KDVDG+ IN G++ GD
Sbjct: 98 EIIDEILKINEDTRVHGLALQI---SENLF-SNKVLNALKPEKDVDGVTDINLGKLVRGD 153
Query: 434 LSGXIPCTPA-GCVELIXKT-GVTIAGK 511
A +EL+ K+ GV + GK
Sbjct: 154 AHECFVSPVAKAVIELLEKSVGVNLDGK 181
Score = 35.5 bits (78), Expect = 0.11
Identities = 22/63 (34%), Positives = 35/63 (55%)
Frame = +3
Query: 63 IENDLRQQVTRLRSKWSGFEPRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRD 242
I+N ++ ++ L+ K F+P LAI+Q G D N+ + AE+ G+ HI LP D
Sbjct: 38 IQNS-KEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLPPD 93
Query: 243 ITE 251
+E
Sbjct: 94 SSE 96
>AK023167-1|BAB14441.1| 236|Homo sapiens ohydrolase (EC 1.5.1.15).
protein.
Length = 236
Score = 45.2 bits (102), Expect = 1e-04
Identities = 21/56 (37%), Positives = 33/56 (58%)
Frame = +2
Query: 344 DAHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGXIPCTPAGCVELIXKTGVTIAGK 511
D + + ++P+KDVDG + IN GR+ + D IP T + E+I +TG+ GK
Sbjct: 43 DERTICNGIAPEKDVDGFHIINIGRLCL-DQHSLIPATASAVWEIIKRTGIQTFGK 97
>BC037529-1|AAH37529.2| 106|Homo sapiens MTHFD2L protein protein.
Length = 106
Score = 41.9 bits (94), Expect = 0.001
Identities = 17/43 (39%), Positives = 29/43 (67%)
Frame = +3
Query: 123 PRLAIVQVGGRXDSNVYIRMKLKAAEKIGIAAEHIRLPRDITE 251
P L+I+ VG S+ Y+R K++AA +GI +E I P+D+++
Sbjct: 24 PHLSIILVGDNPASHTYVRNKIRAASAVGICSELILKPKDVSQ 66
>AL035086-4|CAI42792.1| 120|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 120
Score = 41.9 bits (94), Expect = 0.001
Identities = 21/56 (37%), Positives = 34/56 (60%), Gaps = 1/56 (1%)
Frame = +2
Query: 347 AHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGXIPCTPA-GCVELIXKTGVTIAGK 511
+++V +A+ P+KDVDG+ IN G++ GD A +EL+ K+GV + GK
Sbjct: 11 SNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGK 66
>AL035086-5|CAI42791.1| 120|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 120
Score = 37.5 bits (83), Expect = 0.028
Identities = 21/57 (36%), Positives = 34/57 (59%), Gaps = 2/57 (3%)
Frame = +2
Query: 347 AHRVTDAVSPDKDVDGLNTINEGRVXVGDLSGXIPCTPA-GCVELIXKT-GVTIAGK 511
+++V +A+ P+KDVDG+ IN G++ GD A +EL+ K+ GV + GK
Sbjct: 10 SNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSVGVNLDGK 66
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 63,707,558
Number of Sequences: 237096
Number of extensions: 1092535
Number of successful extensions: 3389
Number of sequences better than 10.0: 26
Number of HSP's better than 10.0 without gapping: 3276
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3366
length of database: 76,859,062
effective HSP length: 85
effective length of database: 56,705,902
effective search space used: 4933413474
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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