Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fbS20010
(420 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q9XYB0 Cluster: PugilistDominant; n=2; Coelomata|Rep: P... 93 2e-18
UniRef50_P11586 Cluster: C-1-tetrahydrofolate synthase, cytoplas... 90 1e-17
UniRef50_UPI00015B59A5 Cluster: PREDICTED: similar to ENSANGP000... 83 2e-15
UniRef50_Q4T2B9 Cluster: Chromosome undetermined SCAF10300, whol... 69 3e-11
UniRef50_Q21285 Cluster: Dauer or aging adult overexpression pro... 69 3e-11
UniRef50_Q63SL6 Cluster: Bifunctional protein folD [Includes: Me... 63 2e-09
UniRef50_A4EAK0 Cluster: Putative uncharacterized protein; n=3; ... 57 2e-07
UniRef50_A1AL91 Cluster: Bifunctional protein folD [Includes: Me... 56 2e-07
UniRef50_Q83FS2 Cluster: Bifunctional protein folD [Includes: Me... 56 4e-07
UniRef50_Q4FNW1 Cluster: Bifunctional protein folD [Includes: Me... 55 7e-07
UniRef50_Q5IWX9 Cluster: Plastid 5,10-methylene-tetrahydrofolate... 54 9e-07
UniRef50_P13995 Cluster: Bifunctional methylenetetrahydrofolate ... 54 9e-07
UniRef50_Q24UZ7 Cluster: Bifunctional protein folD 2 [Includes: ... 54 9e-07
UniRef50_Q8KN38 Cluster: Bifunctional protein folD [Includes: Me... 54 1e-06
UniRef50_Q9LHH7 Cluster: 5,10-methylenetetrahydrofolate dehydrog... 54 2e-06
UniRef50_O65271 Cluster: F6N23.26 protein; n=20; Viridiplantae|R... 53 2e-06
UniRef50_O84081 Cluster: Bifunctional protein folD [Includes: Me... 53 2e-06
UniRef50_O83714 Cluster: Bifunctional protein folD [Includes: Me... 52 4e-06
UniRef50_Q8TK95 Cluster: Bifunctional protein folD [Includes: Me... 52 4e-06
UniRef50_O65269 Cluster: F6N23.28 protein; n=1; Arabidopsis thal... 52 5e-06
UniRef50_Q86F84 Cluster: Clone ZZD1003 mRNA sequence; n=1; Schis... 52 5e-06
UniRef50_Q16F77 Cluster: Methylenetetrahydrofolate dehydrogenase... 52 5e-06
UniRef50_Q7MVE9 Cluster: Bifunctional protein folD [Includes: Me... 52 5e-06
UniRef50_Q74GN1 Cluster: Bifunctional protein folD 1 [Includes: ... 52 5e-06
UniRef50_Q189R8 Cluster: Bifunctional protein folD [Includes: Me... 52 6e-06
UniRef50_Q9A8Y0 Cluster: Bifunctional protein folD [Includes: Me... 51 1e-05
UniRef50_Q5PBL6 Cluster: Bifunctional protein folD [Includes: Me... 51 1e-05
UniRef50_Q8DMU0 Cluster: Bifunctional protein folD [Includes: Me... 50 2e-05
UniRef50_Q9HPY4 Cluster: Bifunctional protein folD [Includes: Me... 50 2e-05
UniRef50_Q0AZF5 Cluster: Bifunctional protein folD 1 [Includes: ... 50 2e-05
UniRef50_A1HML1 Cluster: Methenyltetrahydrofolate cyclohydrolase... 50 3e-05
UniRef50_Q54VK0 Cluster: Methenyl tetrahydrofolate cyclohydrolas... 50 3e-05
UniRef50_Q8EQ43 Cluster: Bifunctional protein folD [Includes: Me... 50 3e-05
UniRef50_Q2B9L0 Cluster: Bifunctional protein FolD; n=1; Bacillu... 49 3e-05
UniRef50_Q6D2E6 Cluster: Bifunctional protein folD [Includes: Me... 48 6e-05
UniRef50_Q6ALZ5 Cluster: Bifunctional protein folD [Includes: Me... 48 6e-05
UniRef50_UPI000038C811 Cluster: COG0190: 5,10-methylene-tetrahyd... 48 1e-04
UniRef50_Q8RAD0 Cluster: Bifunctional protein folD [Includes: Me... 48 1e-04
UniRef50_A7D6I9 Cluster: Methenyltetrahydrofolate cyclohydrolase... 47 1e-04
UniRef50_Q9ZD32 Cluster: Bifunctional protein folD [Includes: Me... 47 1e-04
UniRef50_Q6F1V0 Cluster: Bifunctional protein folD [Includes: Me... 47 1e-04
UniRef50_Q6F9E6 Cluster: Bifunctional protein folD 1 [Includes: ... 47 1e-04
UniRef50_Q4A6B1 Cluster: Bifunctional protein folD [Includes: Me... 47 2e-04
UniRef50_Q1II76 Cluster: Bifunctional protein folD [Includes: Me... 47 2e-04
UniRef50_UPI00015B49ED Cluster: PREDICTED: similar to putative g... 46 2e-04
UniRef50_Q6BNW9 Cluster: Debaryomyces hansenii chromosome E of s... 46 2e-04
UniRef50_Q9KQQ6 Cluster: Bifunctional protein folD [Includes: Me... 46 2e-04
UniRef50_Q3AYX2 Cluster: Bifunctional protein folD [Includes: Me... 46 2e-04
UniRef50_Q5FJG5 Cluster: Bifunctional protein folD [Includes: Me... 46 2e-04
UniRef50_UPI00006CB712 Cluster: tetrahydrofolate dehydrogenase/c... 46 3e-04
UniRef50_Q4RT28 Cluster: Chromosome 12 SCAF14999, whole genome s... 46 4e-04
UniRef50_Q74J95 Cluster: Bifunctional protein folD 1 [Includes: ... 46 4e-04
UniRef50_P47259 Cluster: Bifunctional protein folD [Includes: Me... 45 5e-04
UniRef50_Q6MI74 Cluster: Bifunctional protein folD [Includes: Me... 45 5e-04
UniRef50_Q0SFQ8 Cluster: Bifunctional protein folD 1 [Includes: ... 45 5e-04
UniRef50_UPI000065DF90 Cluster: methylenetetrahydrofolate dehydr... 45 7e-04
UniRef50_Q4S6Y9 Cluster: Chromosome 14 SCAF14723, whole genome s... 45 7e-04
UniRef50_A5IXS7 Cluster: FolD bifunctional protein; n=1; Mycopla... 44 0.001
UniRef50_A7DNA7 Cluster: Methylenetetrahydrofolate dehydrogenase... 44 0.001
UniRef50_Q14NV1 Cluster: Bifunctional protein folD [Includes: Me... 44 0.001
UniRef50_A5CF58 Cluster: Bifunctional protein folD [Includes: Me... 44 0.001
UniRef50_Q5SJ94 Cluster: Bifunctional protein folD [Includes: Me... 44 0.001
UniRef50_Q3YRE3 Cluster: Bifunctional protein folD [Includes: Me... 44 0.001
UniRef50_Q97HC9 Cluster: Bifunctional protein folD [Includes: Me... 44 0.001
UniRef50_P56467 Cluster: Bifunctional protein folD [Includes: Me... 44 0.002
UniRef50_Q4FTX6 Cluster: Bifunctional protein folD [Includes: Me... 43 0.003
UniRef50_Q2UUX1 Cluster: RIB40 genomic DNA, SC009; n=1; Aspergil... 42 0.004
UniRef50_A0JTZ0 Cluster: Bifunctional protein folD [Includes: Me... 42 0.005
UniRef50_Q3A1Q7 Cluster: Bifunctional protein folD [Includes: Me... 41 0.009
UniRef50_UPI0000DB7ABF Cluster: PREDICTED: similar to Bifunction... 40 0.016
UniRef50_Q0AWX5 Cluster: Bifunctional protein folD 2 [Includes: ... 40 0.016
UniRef50_Q979W3 Cluster: Bifunctional protein folD [Includes: Me... 40 0.021
UniRef50_A3PVV6 Cluster: Bifunctional protein folD [Includes: Me... 40 0.021
UniRef50_Q8ZZK1 Cluster: Bifunctional protein folD [Includes: Me... 39 0.036
UniRef50_Q057D7 Cluster: Bifunctional protein folD [Includes: Me... 39 0.036
UniRef50_UPI00006CCCC6 Cluster: methylenetetrahydrofolate dehydr... 38 0.083
UniRef50_Q7TU81 Cluster: Bifunctional protein folD [Includes: Me... 37 0.14
UniRef50_Q6KID0 Cluster: Bifunctional protein folD [Includes: Me... 37 0.14
UniRef50_Q2JCX4 Cluster: Bifunctional protein folD 1 [Includes: ... 37 0.14
UniRef50_Q54Z91 Cluster: Methylenetetrahydrofolate dehydrogenase... 36 0.25
UniRef50_Q8EV80 Cluster: Bifunctional protein folD [Includes: Me... 36 0.25
UniRef50_A7AXK7 Cluster: Putative uncharacterized protein; n=1; ... 36 0.33
UniRef50_Q5RGD2 Cluster: Novel protein similar to vertebrate for... 36 0.44
UniRef50_A5V1H2 Cluster: Methylenetetrahydrofolate dehydrogenase... 36 0.44
UniRef50_A0DMT9 Cluster: Chromosome undetermined scaffold_57, wh... 36 0.44
UniRef50_A6NP56 Cluster: Uncharacterized protein ENSP00000372121... 36 0.44
UniRef50_O51057 Cluster: Bifunctional protein folD [Includes: Me... 36 0.44
UniRef50_UPI0000D9D4E1 Cluster: PREDICTED: similar to Bifunction... 35 0.58
UniRef50_Q8KEH0 Cluster: Methylenetetrahydrofolate dehydrogenase... 35 0.58
UniRef50_Q987T6 Cluster: Bifunctional protein folD 2 [Includes: ... 35 0.58
UniRef50_Q5KEZ0 Cluster: Methylenetetrahydrofolate dehydrogenase... 34 1.0
UniRef50_Q9RW02 Cluster: Bifunctional protein folD [Includes: Me... 34 1.0
UniRef50_A6FY71 Cluster: Histone deacetylase superfamily protein... 33 1.8
UniRef50_A0C3Q0 Cluster: Chromosome undetermined scaffold_147, w... 33 1.8
UniRef50_Q8RDM4 Cluster: Bifunctional protein folD [Includes: Me... 33 1.8
UniRef50_Q4QBW1 Cluster: Methylenetetrahydrofolate dehydrogenase... 33 3.1
UniRef50_Q9X288 Cluster: Bifunctional protein folD [Includes: Me... 33 3.1
UniRef50_Q98QV3 Cluster: Bifunctional protein folD [Includes: Me... 33 3.1
UniRef50_Q1NQA0 Cluster: 4-diphosphocytidyl-2C-methyl-D-erythrit... 32 4.1
UniRef50_Q0A579 Cluster: Putative uncharacterized protein; n=1; ... 32 4.1
UniRef50_UPI00015B4B54 Cluster: PREDICTED: similar to myosin; n=... 32 5.4
UniRef50_Q9KF36 Cluster: BH0650 protein; n=1; Bacillus haloduran... 31 7.2
UniRef50_Q016N9 Cluster: 5'-3' exoribonuclease 1; n=2; Ostreococ... 31 7.2
UniRef50_UPI0000585CF2 Cluster: PREDICTED: similar to beta spect... 31 9.5
UniRef50_Q8KRD2 Cluster: Conserved protein 163; n=21; Streptococ... 31 9.5
UniRef50_Q4VDG8 Cluster: Putative methylene tetrahydrofolate deh... 31 9.5
UniRef50_Q04FB7 Cluster: Bifunctional protein folD [Includes: Me... 31 9.5
>UniRef50_Q9XYB0 Cluster: PugilistDominant; n=2; Coelomata|Rep:
PugilistDominant - Drosophila melanogaster (Fruit fly)
Length = 268
Score = 93.1 bits (221), Expect = 2e-18
Identities = 46/75 (61%), Positives = 57/75 (76%)
Frame = +3
Query: 33 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 212
A+IISG VA SI +LR +VT + + + F P L IVQVGGREDSNVYIRMK+KAA +I
Sbjct: 4 AKIISGTAVAKSIREELRNEVTAMSKQLADFVPGLRIVQVGGREDSNVYIRMKIKAATEI 63
Query: 213 GIAAEHIRLPRDITK 257
GI A H++LPR IT+
Sbjct: 64 GIDAAHVQLPRSITE 78
Score = 89.8 bits (213), Expect = 2e-17
Identities = 40/54 (74%), Positives = 46/54 (85%)
Frame = +2
Query: 257 IELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINE 418
+ELL KI LNE P VHGIIVQMPLD D ID+HR+TDAVSP+KDVDGL+T+NE
Sbjct: 79 VELLDKINDLNEDPRVHGIIVQMPLDCDTPIDSHRITDAVSPEKDVDGLHTVNE 132
>UniRef50_P11586 Cluster: C-1-tetrahydrofolate synthase, cytoplasmic
(C1-THF synthase) [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate
synthetase (EC 6.3.4.3)]; n=86; cellular organisms|Rep:
C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF
synthase) [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate
synthetase (EC 6.3.4.3)] - Homo sapiens (Human)
Length = 935
Score = 90.2 bits (214), Expect = 1e-17
Identities = 42/75 (56%), Positives = 58/75 (77%)
Frame = +3
Query: 33 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 212
A+I++G E++ I L+ QVT+L+ + GF PRLAI+QVG R+DSN+YI +KLKAAE+I
Sbjct: 4 AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63
Query: 213 GIAAEHIRLPRDITK 257
GI A HI+LPR T+
Sbjct: 64 GIKATHIKLPRTTTE 78
Score = 67.3 bits (157), Expect = 1e-10
Identities = 28/52 (53%), Positives = 42/52 (80%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
E++ ITSLNE +VHG +VQ+PLDS+++I+ V +A++P+KDVDGL +IN
Sbjct: 80 EVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKDVDGLTSIN 131
>UniRef50_UPI00015B59A5 Cluster: PREDICTED: similar to
ENSANGP00000016878; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000016878 - Nasonia
vitripennis
Length = 866
Score = 83.0 bits (196), Expect = 2e-15
Identities = 40/62 (64%), Positives = 45/62 (72%)
Frame = +2
Query: 233 PLTKGHH*IELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTI 412
P T H ELL K+ LN P HGIIVQMPLDS + I++H +TD VSPDKDVDGLNTI
Sbjct: 76 PNTTTEH--ELLTKLNKLNNDPDTHGIIVQMPLDSVNKINSHLITDTVSPDKDVDGLNTI 133
Query: 413 NE 418
NE
Sbjct: 134 NE 135
Score = 81.8 bits (193), Expect = 5e-15
Identities = 37/73 (50%), Positives = 51/73 (69%)
Frame = +3
Query: 39 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGI 218
++SG ++A I L + V ++ K + P LAIVQVGGREDSNVYIRMK+KAA +IGI
Sbjct: 9 VLSGTDLAKEIRESLAKDVAAIQQKLPNYAPGLAIVQVGGREDSNVYIRMKIKAASEIGI 68
Query: 219 AAEHIRLPRDITK 257
A H+++P T+
Sbjct: 69 KATHVKMPNTTTE 81
>UniRef50_Q4T2B9 Cluster: Chromosome undetermined SCAF10300, whole
genome shotgun sequence; n=6; Clupeocephala|Rep:
Chromosome undetermined SCAF10300, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 348
Score = 69.3 bits (162), Expect = 3e-11
Identities = 32/52 (61%), Positives = 40/52 (76%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
E+L I S+NE SVHG+IVQ+PLDS H ID+ +T+ VS DKDVDGL+ IN
Sbjct: 126 EVLLNILSINEDQSVHGLIVQLPLDSVHHIDSECITNTVSADKDVDGLSCIN 177
Score = 52.4 bits (120), Expect = 4e-06
Identities = 28/59 (47%), Positives = 40/59 (67%)
Frame = +3
Query: 81 LRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITK 257
L Q++ RL S F + ++QVG R+DSN+YI K+KAA +IGI A+H+RLP T+
Sbjct: 68 LGQKLLRLLVLTSVF--LVTLLQVGDRDDSNLYISAKMKAAAEIGIDAKHVRLPSSATQ 124
>UniRef50_Q21285 Cluster: Dauer or aging adult overexpression
protein 3; n=2; Caenorhabditis|Rep: Dauer or aging adult
overexpression protein 3 - Caenorhabditis elegans
Length = 303
Score = 69.3 bits (162), Expect = 3e-11
Identities = 34/76 (44%), Positives = 50/76 (65%)
Frame = +3
Query: 30 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEK 209
+A+I+SG+E + + +D+ Q++ + R F LAIVQVG R DSNVYI KLK A++
Sbjct: 2 VAEIVSGLEYSKKVLHDVGQKIAKTREHHPNFHAVLAIVQVGNRSDSNVYINSKLKKAKE 61
Query: 210 IGIAAEHIRLPRDITK 257
IG + I+LP IT+
Sbjct: 62 IGADGKLIKLPDTITQ 77
Score = 56.4 bits (130), Expect = 2e-07
Identities = 26/52 (50%), Positives = 33/52 (63%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
+L +I +LN + GII+Q+PLD H IDA V D + P KDVDGL IN
Sbjct: 79 DLKREIMALNHDNEIDGIIIQLPLDCKHEIDADSVIDLIDPLKDVDGLTRIN 130
>UniRef50_Q63SL6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=226; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Burkholderia pseudomallei (Pseudomonas
pseudomallei)
Length = 285
Score = 63.3 bits (147), Expect = 2e-09
Identities = 30/62 (48%), Positives = 42/62 (67%)
Frame = +2
Query: 230 YPLTKGHH*IELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 409
YP T ELLA+I LN P +HGI+VQ+PL + ID+H+V +A++P+KDVDG +
Sbjct: 69 YPATLSEP--ELLARIDELNRDPKIHGILVQLPLPAH--IDSHKVIEAIAPEKDVDGFHV 124
Query: 410 IN 415
N
Sbjct: 125 AN 126
Score = 37.1 bits (82), Expect = 0.14
Identities = 21/75 (28%), Positives = 38/75 (50%)
Frame = +3
Query: 33 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 212
A +I G ++ ++ ++ L ++ G P LA++ VG S VY+R K+KA E
Sbjct: 3 ATLIDGNALSKTLRAQAAERAAALAAR--GHRPGLAVILVGDNPASEVYVRNKIKACEDN 60
Query: 213 GIAAEHIRLPRDITK 257
G + R P +++
Sbjct: 61 GFFSLKDRYPATLSE 75
>UniRef50_A4EAK0 Cluster: Putative uncharacterized protein; n=3;
Bacteria|Rep: Putative uncharacterized protein -
Collinsella aerofaciens ATCC 25986
Length = 284
Score = 56.8 bits (131), Expect = 2e-07
Identities = 31/76 (40%), Positives = 45/76 (59%)
Frame = +3
Query: 30 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEK 209
MA+++ G VA ++ +L + LR + G P LAIV+VG RED Y R LK EK
Sbjct: 1 MAELLKGAPVARALTEELAARCAALREQ--GVVPMLAIVRVGEREDDLSYERGALKRCEK 58
Query: 210 IGIAAEHIRLPRDITK 257
+GI A + LP D+++
Sbjct: 59 VGIEARRVLLPVDVSQ 74
Score = 39.5 bits (88), Expect = 0.027
Identities = 20/48 (41%), Positives = 28/48 (58%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGL 403
ELLA I +N P+VHG ++ PL + +D V A+ P KDVD +
Sbjct: 76 ELLAAIKDINADPAVHGCLMFRPLPA--GLDEDAVAAALDPAKDVDSM 121
>UniRef50_A1AL91 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=9; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Pelobacter propionicus (strain DSM 2379)
Length = 283
Score = 56.4 bits (130), Expect = 2e-07
Identities = 27/52 (51%), Positives = 35/52 (67%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
ELLA + LN P +HGI+VQ+PL S ID +V +A+SP KDVDG + N
Sbjct: 76 ELLALVELLNNDPKIHGILVQLPLPSQ--IDTDKVLEAISPFKDVDGFHPYN 125
>UniRef50_Q83FS2 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Tropheryma whipplei|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Tropheryma whipplei (strain Twist)
(Whipple's bacillus)
Length = 295
Score = 55.6 bits (128), Expect = 4e-07
Identities = 26/52 (50%), Positives = 38/52 (73%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
EL++K+ LN S V GIIVQ+PL +ID ++V +A++PDKD DGL+ +N
Sbjct: 77 ELISKVEILNASSDVSGIIVQLPLPE--SIDQNKVIEAINPDKDADGLHPLN 126
Score = 36.7 bits (81), Expect = 0.19
Identities = 22/76 (28%), Positives = 39/76 (51%)
Frame = +3
Query: 30 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEK 209
+A+++ G+ V+ I L + L + +G P+LA V VG S Y+ K + +
Sbjct: 2 VAKVLDGLAVSAGIFERLHRACCELEN--NGVCPKLATVLVGNNPASRSYVLSKHRDCKN 59
Query: 210 IGIAAEHIRLPRDITK 257
IGI + I LP + ++
Sbjct: 60 IGIQSTLIELPANTSE 75
>UniRef50_Q4FNW1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Pelagibacter ubique
Length = 281
Score = 54.8 bits (126), Expect = 7e-07
Identities = 25/71 (35%), Positives = 43/71 (60%)
Frame = +3
Query: 39 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGI 218
+I G ++A + LRQ+V L++K + P L ++ +G S +Y+RMK KAA ++G+
Sbjct: 3 LIDGKKIAAELREQLRQEVVELKAKHNKI-PGLTVILIGEMAPSQIYVRMKEKAANEVGL 61
Query: 219 AAEHIRLPRDI 251
+E IR P +
Sbjct: 62 KSEVIRYPEAV 72
Score = 45.6 bits (103), Expect = 4e-04
Identities = 22/51 (43%), Positives = 32/51 (62%)
Frame = +2
Query: 263 LLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
+L KI LN+ S+ GI+VQ+PL ID +V + + P KDVDG + +N
Sbjct: 77 VLDKIEELNKDESISGILVQLPLPKH--IDKQKVIETILPGKDVDGFHPMN 125
>UniRef50_Q5IWX9 Cluster: Plastid 5,10-methylene-tetrahydrofolate
dehydrogenase; n=1; Prototheca wickerhamii|Rep: Plastid
5,10-methylene-tetrahydrofolate dehydrogenase -
Prototheca wickerhamii
Length = 248
Score = 54.4 bits (125), Expect = 9e-07
Identities = 29/78 (37%), Positives = 48/78 (61%)
Frame = +3
Query: 24 AKMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAA 203
A A +I G ++A +I +L+ +V LR++++ P LA+V VG R+DS Y+R K KA
Sbjct: 59 AMPAALIDGKKIAETIRGELKVEVDELRAQYNTV-PGLAVVLVGERKDSQTYVRSKKKAC 117
Query: 204 EKIGIAAEHIRLPRDITK 257
+++GI + LP T+
Sbjct: 118 DEVGINSFGADLPETATE 135
Score = 52.8 bits (121), Expect = 3e-06
Identities = 26/52 (50%), Positives = 37/52 (71%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
E+LA + N+ P+VHGI+VQ+PL +H I+ RV DA+S +KDVDG + N
Sbjct: 137 EVLAVVAKFNDDPNVHGILVQLPL-PEH-INEKRVLDAISLEKDVDGFHPNN 186
>UniRef50_P13995 Cluster: Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor
[Includes: NAD-dependent methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)]; n=66; cellular
organisms|Rep: Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor
[Includes: NAD-dependent methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Homo sapiens (Human)
Length = 350
Score = 54.4 bits (125), Expect = 9e-07
Identities = 28/52 (53%), Positives = 36/52 (69%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
ELL I LN +V G++VQ+PL +H ID R+ +AVSPDKDVDG + IN
Sbjct: 112 ELLNLINKLNNDDNVDGLLVQLPLP-EH-IDERRICNAVSPDKDVDGFHVIN 161
Score = 41.9 bits (94), Expect = 0.005
Identities = 24/75 (32%), Positives = 42/75 (56%)
Frame = +3
Query: 33 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 212
A +ISG ++A I+ ++RQ+V + P L+++ VG S+ Y+ K +AA +
Sbjct: 37 AVVISGRKLAQQIKQEVRQEVEEWVAS-GNKRPHLSVILVGENPASHSYVLNKTRAAAVV 95
Query: 213 GIAAEHIRLPRDITK 257
GI +E I P I++
Sbjct: 96 GINSETIMKPASISE 110
>UniRef50_Q24UZ7 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Peptococcaceae|Rep: Bifunctional protein folD 2
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Desulfitobacterium hafniense (strain Y51)
Length = 284
Score = 54.4 bits (125), Expect = 9e-07
Identities = 27/51 (52%), Positives = 35/51 (68%)
Frame = +2
Query: 263 LLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
+LA I SLN +P VHGI++++PL I RV AV PDKDVDG++ IN
Sbjct: 77 ILALIDSLNANPDVHGIMIELPLPKH--ISKERVMAAVRPDKDVDGVHPIN 125
Score = 48.8 bits (111), Expect = 4e-05
Identities = 25/73 (34%), Positives = 44/73 (60%)
Frame = +3
Query: 30 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEK 209
MAQ++ G E++ ++ +++++V R + + G P+LA+V VG S VY + K K ++
Sbjct: 1 MAQLLDGKEISKVLKEEIKEEVKRWKEQ--GVNPKLAVVLVGDDPASVVYAKSKQKVSDS 58
Query: 210 IGIAAEHIRLPRD 248
+GI E LP D
Sbjct: 59 LGIDFELTVLPAD 71
>UniRef50_Q8KN38 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Sphingobium chlorophenolicum|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Sphingobium
chlorophenolicum
Length = 316
Score = 54.0 bits (124), Expect = 1e-06
Identities = 26/52 (50%), Positives = 35/52 (67%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
+LLA I SLN VHGI+VQ+PL + ID+ +V D + P KDVDG + +N
Sbjct: 77 DLLALIASLNADERVHGILVQLPLPAQ--IDSGKVLDTIDPRKDVDGFHPVN 126
Score = 51.2 bits (117), Expect = 8e-06
Identities = 28/76 (36%), Positives = 42/76 (55%)
Frame = +3
Query: 30 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEK 209
MA IISG A + DL + V R S+ G+ P L V VG S++Y+R K++ K
Sbjct: 1 MASIISGTAAAEGLLADLTRDVARF-SQVHGYAPTLVAVLVGDDPASHIYVRKKIEQCRK 59
Query: 210 IGIAAEHIRLPRDITK 257
+G+ + RLP D ++
Sbjct: 60 VGMESVEHRLPADCSE 75
>UniRef50_Q9LHH7 Cluster: 5,10-methylenetetrahydrofolate
dehydrogenase/5,10- methenyltetrahydrofolate
cyclohydrolase; n=7; Eukaryota|Rep:
5,10-methylenetetrahydrofolate dehydrogenase/5,10-
methenyltetrahydrofolate cyclohydrolase - Arabidopsis
thaliana (Mouse-ear cress)
Length = 299
Score = 53.6 bits (123), Expect = 2e-06
Identities = 27/75 (36%), Positives = 46/75 (61%)
Frame = +3
Query: 33 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 212
A+II G +A +I +++ ++V L K G P LA+V VG R+DS Y+ K KA ++
Sbjct: 9 AKIIDGKAIAHTIRSEIAEEVRGLSEK-HGKVPGLAVVIVGSRKDSQTYVNTKRKACAEV 67
Query: 213 GIAAEHIRLPRDITK 257
GI + + LP ++++
Sbjct: 68 GIKSFDVGLPEEVSE 82
Score = 52.0 bits (119), Expect = 5e-06
Identities = 24/52 (46%), Positives = 36/52 (69%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
+L++K+ LN +P VHGI+VQ+PL H + H + A+S DKDVDG + +N
Sbjct: 84 DLISKVHELNSNPDVHGILVQLPLPK-HINEEH-ILGAISIDKDVDGFHPLN 133
>UniRef50_O65271 Cluster: F6N23.26 protein; n=20; Viridiplantae|Rep:
F6N23.26 protein - Arabidopsis thaliana (Mouse-ear
cress)
Length = 360
Score = 53.2 bits (122), Expect = 2e-06
Identities = 24/52 (46%), Positives = 36/52 (69%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
E+L ++ N+ PSVHGI+VQ+PL S +D + +AVS +KDVDG + +N
Sbjct: 144 EVLKSVSGFNDDPSVHGILVQLPLPSH--MDEQNILNAVSIEKDVDGFHPLN 193
Score = 52.4 bits (120), Expect = 4e-06
Identities = 27/72 (37%), Positives = 43/72 (59%)
Frame = +3
Query: 33 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 212
A +I G VA I +++ +V+R++ G P LA++ VG R+DS Y+R K KA + +
Sbjct: 69 AIVIDGKAVAKKIRDEITIEVSRMKES-IGVIPGLAVILVGDRKDSATYVRNKKKACDSV 127
Query: 213 GIAAEHIRLPRD 248
GI + +RL D
Sbjct: 128 GIKSFEVRLAED 139
>UniRef50_O84081 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Chlamydiaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Chlamydia trachomatis
Length = 287
Score = 53.2 bits (122), Expect = 2e-06
Identities = 23/52 (44%), Positives = 35/52 (67%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
++LA I LN ++HGI+VQ+PL +DA + ++PDKDVDGL+ +N
Sbjct: 71 DILALIHQLNNDENIHGILVQLPLPKH--LDAQAILSTITPDKDVDGLHPVN 120
Score = 39.1 bits (87), Expect = 0.036
Identities = 16/42 (38%), Positives = 25/42 (59%)
Frame = +3
Query: 129 PRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDIT 254
P LA+V +G S +Y+ MK+K A +G+ ++ R P D T
Sbjct: 27 PGLAVVLIGNNPASEIYVNMKIKRATDLGMVSKSYRKPSDAT 68
>UniRef50_O83714 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Treponema pallidum
Length = 315
Score = 52.4 bits (120), Expect = 4e-06
Identities = 25/52 (48%), Positives = 36/52 (69%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
++L I LNE VHGI++Q+PL + +DA RV AV+P+KDVDG + +N
Sbjct: 78 QVLELIARLNEDARVHGILIQLPLPAH--LDAARVCRAVAPEKDVDGFHPLN 127
>UniRef50_Q8TK95 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Methanosarcina acetivorans
Length = 290
Score = 52.4 bits (120), Expect = 4e-06
Identities = 29/75 (38%), Positives = 43/75 (57%)
Frame = +3
Query: 33 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 212
++II G +A +E ++R V L S G P LA + VG S +Y+R+K +A E++
Sbjct: 8 SRIIDGKVLAQQVEEEVRSGVEDLESN-RGIVPGLATILVGDDPASKMYVRLKHRACERV 66
Query: 213 GIAAEHIRLPRDITK 257
GI AE LP D T+
Sbjct: 67 GIKAEDYLLPGDATQ 81
Score = 43.6 bits (98), Expect = 0.002
Identities = 21/53 (39%), Positives = 31/53 (58%), Gaps = 1/53 (1%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHA-IDAHRVTDAVSPDKDVDGLNTIN 415
ELL I SLN++ VH I++Q+PL + + +A+SP KD DG + N
Sbjct: 83 ELLTLIDSLNKNKDVHAILLQLPLPKHFSPQETQEAMEAISPTKDADGFHPYN 135
>UniRef50_O65269 Cluster: F6N23.28 protein; n=1; Arabidopsis
thaliana|Rep: F6N23.28 protein - Arabidopsis thaliana
(Mouse-ear cress)
Length = 310
Score = 52.0 bits (119), Expect = 5e-06
Identities = 23/52 (44%), Positives = 36/52 (69%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
E+L ++ N+ PSVHG++VQ+PL S +D + +AVS +KDVDG + +N
Sbjct: 94 EVLKYVSGFNDDPSVHGVLVQLPLPSH--MDEQNILNAVSIEKDVDGFHPLN 143
>UniRef50_Q86F84 Cluster: Clone ZZD1003 mRNA sequence; n=1;
Schistosoma japonicum|Rep: Clone ZZD1003 mRNA sequence -
Schistosoma japonicum (Blood fluke)
Length = 332
Score = 52.0 bits (119), Expect = 5e-06
Identities = 25/73 (34%), Positives = 45/73 (61%)
Frame = +3
Query: 39 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGI 218
I+ G +VA ++ + ++ V L+S + + P+L +++VG S +YI+ K K A+K GI
Sbjct: 6 ILYGRQVAQAVGHKIKLDVALLKSSFDVY-PKLVVIEVGELPQSKLYIKQKFKFAKKYGI 64
Query: 219 AAEHIRLPRDITK 257
H+RLP I++
Sbjct: 65 LLSHMRLPSHISE 77
Score = 49.2 bits (112), Expect = 3e-05
Identities = 24/51 (47%), Positives = 32/51 (62%)
Frame = +2
Query: 263 LLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
LL + LN SVHGI +Q+P DSD I+ +AV+ KDV+GLN+ N
Sbjct: 80 LLDYVYKLNADSSVHGITLQLPFDSDTNINVTNSLNAVATHKDVEGLNSYN 130
>UniRef50_Q16F77 Cluster: Methylenetetrahydrofolate dehydrogenase;
n=4; cellular organisms|Rep: Methylenetetrahydrofolate
dehydrogenase - Aedes aegypti (Yellowfever mosquito)
Length = 337
Score = 52.0 bits (119), Expect = 5e-06
Identities = 25/77 (32%), Positives = 42/77 (54%)
Frame = +3
Query: 27 KMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAE 206
+MA++I G ++A I +LR+Q+ + P L + +G SN Y+ K+KAA
Sbjct: 31 EMAKLIDGKQIAADIRMELREQIEEWMKQGGNRAPHLTAILIGEDPASNTYVSNKMKAAA 90
Query: 207 KIGIAAEHIRLPRDITK 257
+GI ++ R DIT+
Sbjct: 91 DVGITSKTERYSADITE 107
Score = 46.4 bits (105), Expect = 2e-04
Identities = 24/52 (46%), Positives = 34/52 (65%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
+LL +I LN+ SV GI+VQ+P+ I+ +V ++VS DKDVDG N N
Sbjct: 109 QLLKRIEELNQDDSVDGILVQLPVPGH--INERKVCNSVSCDKDVDGFNERN 158
>UniRef50_Q7MVE9 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=52; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Porphyromonas gingivalis (Bacteroides gingivalis)
Length = 296
Score = 52.0 bits (119), Expect = 5e-06
Identities = 26/52 (50%), Positives = 34/52 (65%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
ELLA + LN+ P+V G IVQ+PL ID ++ +AV P KDVDG + IN
Sbjct: 80 ELLACVHRLNQDPTVDGFIVQLPLPKH--IDEQKIIEAVDPRKDVDGFHPIN 129
>UniRef50_Q74GN1 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Bacteria|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Geobacter sulfurreducens
Length = 290
Score = 52.0 bits (119), Expect = 5e-06
Identities = 24/52 (46%), Positives = 35/52 (67%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
ELLAKI +NE P+ G+IVQ+PL I+ V +A++P+KD+DG + N
Sbjct: 76 ELLAKIKEVNEDPTTDGLIVQLPLPKH--INQQHVINAIAPEKDIDGFHPAN 125
>UniRef50_Q189R8 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=11; Clostridiales|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Clostridium difficile (strain 630)
Length = 290
Score = 51.6 bits (118), Expect = 6e-06
Identities = 31/74 (41%), Positives = 40/74 (54%)
Frame = +3
Query: 36 QIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIG 215
QII G VA I +L ++V L + G P+L IV+VG R D Y R LK + IG
Sbjct: 9 QIIKGKPVADKISEELIKEVDLLVKE--GINPKLTIVRVGARSDDLSYERGALKRCQNIG 66
Query: 216 IAAEHIRLPRDITK 257
I E + L DIT+
Sbjct: 67 ITTEVLELAEDITQ 80
>UniRef50_Q9A8Y0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=82; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Caulobacter crescentus (Caulobacter
vibrioides)
Length = 297
Score = 50.8 bits (116), Expect = 1e-05
Identities = 25/52 (48%), Positives = 31/52 (59%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
ELLA + LN P +HG++VQ P+ I V A+SPDKDVDGL N
Sbjct: 79 ELLAVVAKLNADPKIHGVLVQFPVPPH--ISQMDVVAALSPDKDVDGLTVTN 128
Score = 39.9 bits (89), Expect = 0.021
Identities = 24/75 (32%), Positives = 39/75 (52%)
Frame = +3
Query: 33 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 212
A++I G A + + ++V L+++ G P LA+V VG S VY+R K +
Sbjct: 4 AKLIDGKAFAADLRAKIAEEVAALKAE-HGVTPGLAVVLVGEDPASQVYVRNKGEQTTAA 62
Query: 213 GIAAEHIRLPRDITK 257
G+ +E RLP T+
Sbjct: 63 GMYSETHRLPETTTQ 77
>UniRef50_Q5PBL6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Alphaproteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Anaplasma marginale (strain St. Maries)
Length = 299
Score = 50.8 bits (116), Expect = 1e-05
Identities = 26/52 (50%), Positives = 33/52 (63%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
ELL I LN +VHGI+VQ+PL ID V +A+SP+KDVDG + N
Sbjct: 77 ELLRIIDELNRDAAVHGILVQLPL--PRHIDKELVINAISPEKDVDGFHNAN 126
>UniRef50_Q8DMU0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=90; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Synechococcus elongatus (Thermosynechococcus
elongatus)
Length = 306
Score = 50.0 bits (114), Expect = 2e-05
Identities = 28/78 (35%), Positives = 42/78 (53%)
Frame = +3
Query: 24 AKMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAA 203
A A + G +A SIE L V +++W G P LA+++VG S VY+R K +A
Sbjct: 3 AHAATCLDGKSLAQSIERQLADHVRTFQAQW-GRSPGLAVLRVGNDPASAVYVRAKEQAC 61
Query: 204 EKIGIAAEHIRLPRDITK 257
++GI + LP IT+
Sbjct: 62 SRVGIQSFGAHLPATITE 79
Score = 48.0 bits (109), Expect = 8e-05
Identities = 25/51 (49%), Positives = 33/51 (64%)
Frame = +2
Query: 263 LLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
LLAKIT LN+ V GI++Q+PL +D + A+ PDKDVDGL+ N
Sbjct: 82 LLAKITELNQDERVDGILLQLPLPPH--LDPRPLLYAIHPDKDVDGLHPEN 130
>UniRef50_Q9HPY4 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Halobacterium salinarium (Halobacterium
halobium)
Length = 297
Score = 50.0 bits (114), Expect = 2e-05
Identities = 27/70 (38%), Positives = 40/70 (57%)
Frame = +3
Query: 30 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEK 209
M +II G VA + DL V L + +G PRLA V + ++ S Y+ MK + E+
Sbjct: 1 MTEIIDGDAVAAQLRADLTGAVETLET--AGVTPRLATVLMNDKQASETYVSMKQQDCEE 58
Query: 210 IGIAAEHIRL 239
+GIAAE +R+
Sbjct: 59 VGIAAEDVRI 68
Score = 41.1 bits (92), Expect = 0.009
Identities = 24/51 (47%), Positives = 27/51 (52%)
Frame = +2
Query: 263 LLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
L + LN VHGI+VQ P DH D RV AV P KDVDG + N
Sbjct: 77 LFDTVAELNAREDVHGILVQDPTP-DHVPD-ERVLSAVDPAKDVDGFHPEN 125
>UniRef50_Q0AZF5 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Syntrophomonas wolfei subsp. wolfei str.
Goettingen|Rep: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Syntrophomonas wolfei subsp. wolfei (strain Goettingen)
Length = 277
Score = 50.0 bits (114), Expect = 2e-05
Identities = 22/52 (42%), Positives = 32/52 (61%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
EL+AKI LN+ V GI++Q+PL + + A+ PDKDVDG + +N
Sbjct: 72 ELMAKIAELNQDEQVDGILLQLPLPAALEEQTDEILAAIRPDKDVDGFSLVN 123
Score = 41.9 bits (94), Expect = 0.005
Identities = 24/74 (32%), Positives = 41/74 (55%)
Frame = +3
Query: 36 QIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIG 215
+IISG ++A I L+++ R G P LA++ VGG+++ Y+ +K KAA G
Sbjct: 2 EIISGSQIAQEIRQKLKEKNER-----EGISPCLAMILVGGQKEDLHYVGLKEKAATATG 56
Query: 216 IAAEHIRLPRDITK 257
+ + LP D ++
Sbjct: 57 GKSRLLHLPEDTSQ 70
>UniRef50_A1HML1 Cluster: Methenyltetrahydrofolate cyclohydrolase;
n=1; Thermosinus carboxydivorans Nor1|Rep:
Methenyltetrahydrofolate cyclohydrolase - Thermosinus
carboxydivorans Nor1
Length = 279
Score = 49.6 bits (113), Expect = 3e-05
Identities = 25/52 (48%), Positives = 33/52 (63%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
E+LA + LNE +HGI+ MPL A D RV A++PDKDVD L+ +N
Sbjct: 76 EVLALVCELNEDDHIHGILPMMPLPPHLATD--RVAAALAPDKDVDALHPLN 125
Score = 32.3 bits (70), Expect = 4.1
Identities = 23/76 (30%), Positives = 37/76 (48%)
Frame = +3
Query: 30 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEK 209
MA I+ G VA + + ++ +V L ++ LAI+ VG S +Y +K A
Sbjct: 1 MALILDGKAVAAAYKAKIKAKVDALAAQ--NITCGLAILLVGNDAASRIYADRLVKLATG 58
Query: 210 IGIAAEHIRLPRDITK 257
+G+ A LP D T+
Sbjct: 59 LGVQAVVRHLPADATE 74
>UniRef50_Q54VK0 Cluster: Methenyl tetrahydrofolate cyclohydrolase /
NADP-dependent methylene H4F dehydrogenase; n=1;
Dictyostelium discoideum AX4|Rep: Methenyl
tetrahydrofolate cyclohydrolase / NADP-dependent
methylene H4F dehydrogenase - Dictyostelium discoideum
AX4
Length = 440
Score = 49.6 bits (113), Expect = 3e-05
Identities = 25/52 (48%), Positives = 34/52 (65%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
+L+ KI +E PSVHGIIVQ+PL + DA + ++ P KDVDGL + N
Sbjct: 161 QLIKKIKYHSEDPSVHGIIVQLPLPDNLNKDA--IIQSIDPKKDVDGLTSTN 210
>UniRef50_Q8EQ43 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=45; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Oceanobacillus iheyensis
Length = 285
Score = 49.6 bits (113), Expect = 3e-05
Identities = 25/52 (48%), Positives = 32/52 (61%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
ELL I N SVHGI+VQ+PL +D ++ A+SP KDVDG + IN
Sbjct: 76 ELLQIIDEQNNDDSVHGILVQLPLPDQ--MDEQKIIHAISPAKDVDGFHPIN 125
>UniRef50_Q2B9L0 Cluster: Bifunctional protein FolD; n=1; Bacillus
sp. NRRL B-14911|Rep: Bifunctional protein FolD -
Bacillus sp. NRRL B-14911
Length = 322
Score = 49.2 bits (112), Expect = 3e-05
Identities = 26/72 (36%), Positives = 38/72 (52%)
Frame = +3
Query: 39 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGI 218
I+ G VA ++ L +V L K G P LA + VG S Y+RMK A ++GI
Sbjct: 45 ILDGKRVAADVKEGLMPRVENLTQK--GITPCLATILVGDDPSSETYVRMKGNACARLGI 102
Query: 219 AAEHIRLPRDIT 254
+E I +P++ T
Sbjct: 103 RSERIHMPKETT 114
Score = 43.2 bits (97), Expect = 0.002
Identities = 21/50 (42%), Positives = 31/50 (62%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 409
EL+ I LNE+ VHGI++Q P+ ID + + +S DKDVDG+ +
Sbjct: 117 ELVKTIEELNENKEVHGILLQHPVPGH--IDERKAFETISIDKDVDGVTS 164
>UniRef50_Q6D2E6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Erwinia carotovora subsp. atroseptica (Pectobacterium
atrosepticum)
Length = 287
Score = 48.4 bits (110), Expect = 6e-05
Identities = 24/52 (46%), Positives = 33/52 (63%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
ELLA I LN ++ GI+VQ+PL ID +V + ++PDKDVDG + N
Sbjct: 78 ELLALIDQLNADQAIDGILVQLPL--PEGIDNTKVIERIAPDKDVDGFHPYN 127
>UniRef50_Q6ALZ5 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=27; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Desulfotalea psychrophila
Length = 296
Score = 48.4 bits (110), Expect = 6e-05
Identities = 22/52 (42%), Positives = 31/52 (59%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
ELLA I N S+HG++VQ+PL I+ + A+ PDKDVD + +N
Sbjct: 78 ELLALIEKYNNDDSIHGVLVQLPLPKH--INEQNIITAIDPDKDVDAFHPVN 127
>UniRef50_UPI000038C811 Cluster: COG0190:
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl
tetrahydrofolate cyclohydrolase; n=1; Nostoc punctiforme
PCC 73102|Rep: COG0190: 5,10-methylene-tetrahydrofolate
dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase -
Nostoc punctiforme PCC 73102
Length = 292
Score = 47.6 bits (108), Expect = 1e-04
Identities = 26/76 (34%), Positives = 42/76 (55%)
Frame = +3
Query: 27 KMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAE 206
K A+++ G +A I+ +L +T+L+ + G P LA++ VG S Y+R K KA
Sbjct: 4 KTAKLLDGKAIAAKIQQELSVAITQLQPE-IGRPPGLAVLMVGDNPASAAYVRNKEKACA 62
Query: 207 KIGIAAEHIRLPRDIT 254
K+GIA+ P + T
Sbjct: 63 KVGIASFGKHFPAETT 78
Score = 46.0 bits (104), Expect = 3e-04
Identities = 24/52 (46%), Positives = 33/52 (63%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
EL I +LN+ V GI+VQ+PL DH +DA + + PDKD DGL+ +N
Sbjct: 81 ELEKVIAALNDDERVDGILVQLPLP-DH-LDAVALLHQIDPDKDADGLHPVN 130
>UniRef50_Q8RAD0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Thermoanaerobacter|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermoanaerobacter tengcongensis
Length = 280
Score = 47.6 bits (108), Expect = 1e-04
Identities = 23/63 (36%), Positives = 38/63 (60%)
Frame = +3
Query: 39 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGI 218
II G E++ I+ ++++++ G++PRLAI+ G E S VY K+KA E +GI
Sbjct: 5 IIDGKEISNRIKEEVKREIQEF-----GYKPRLAILMAGDDESSKVYANSKVKACESVGI 59
Query: 219 AAE 227
A+
Sbjct: 60 EAK 62
Score = 40.3 bits (90), Expect = 0.016
Identities = 18/47 (38%), Positives = 27/47 (57%)
Frame = +2
Query: 275 ITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
+ LNE HGI+++MPL D +V D ++P KDVD ++ N
Sbjct: 78 LEKLNEDKDTHGIMIEMPLPK--GFDVDKVYDTINPYKDVDCISNYN 122
>UniRef50_A7D6I9 Cluster: Methenyltetrahydrofolate cyclohydrolase;
n=1; Halorubrum lacusprofundi ATCC 49239|Rep:
Methenyltetrahydrofolate cyclohydrolase - Halorubrum
lacusprofundi ATCC 49239
Length = 307
Score = 47.2 bits (107), Expect = 1e-04
Identities = 25/52 (48%), Positives = 32/52 (61%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
EL I LNE VHGI+VQ+P+ DH +D RV ++P KDVDG + N
Sbjct: 86 ELYETIDDLNEREDVHGILVQLPV-PDH-VDKRRVLRQIAPVKDVDGFHPEN 135
>UniRef50_Q9ZD32 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Rickettsia|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rickettsia prowazekii
Length = 286
Score = 47.2 bits (107), Expect = 1e-04
Identities = 23/52 (44%), Positives = 33/52 (63%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
+L+ KI LN + GIIVQ+PL S +ID +++ AV P KD DG + +N
Sbjct: 78 DLILKINELNLDKGISGIIVQLPLPS--SIDENKILSAVLPSKDSDGFHPLN 127
Score = 41.5 bits (93), Expect = 0.007
Identities = 24/71 (33%), Positives = 39/71 (54%)
Frame = +3
Query: 39 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGI 218
II G +A I DL+ ++ + K + P+LAIV VG S +Y++ K+K A ++GI
Sbjct: 5 IIDGKALANEILADLKLEIQGFKEK-TKTSPKLAIVLVGDNPASMIYVKNKIKNAHQVGI 63
Query: 219 AAEHIRLPRDI 251
+ L +I
Sbjct: 64 DTLLVNLSTNI 74
>UniRef50_Q6F1V0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Mollicutes|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mesoplasma florum (Acholeplasma florum)
Length = 286
Score = 47.2 bits (107), Expect = 1e-04
Identities = 23/73 (31%), Positives = 43/73 (58%)
Frame = +3
Query: 39 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGI 218
I+ G +VA + +L ++++ +K +P+L ++ VG S VY+ K+K A ++GI
Sbjct: 3 ILDGKKVASRRKEELTAKISKYHNKGLR-KPKLVVIMVGNDPASEVYVSHKIKVANEVGI 61
Query: 219 AAEHIRLPRDITK 257
+E +R +DI K
Sbjct: 62 YSELLRFDKDIKK 74
Score = 43.2 bits (97), Expect = 0.002
Identities = 21/53 (39%), Positives = 32/53 (60%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINE 418
EL KI LN ++ GI++Q+PL D + + A++P KDVDG + IN+
Sbjct: 76 ELYNKINELNNDQNIDGILLQLPLPIDFIEEDY--LQAITPSKDVDGFHYINQ 126
>UniRef50_Q6F9E6 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Proteobacteria|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Acinetobacter sp. (strain ADP1)
Length = 297
Score = 47.2 bits (107), Expect = 1e-04
Identities = 24/52 (46%), Positives = 32/52 (61%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
ELL +I LN VHGI+VQ+PL I+ RV + + P KDVDG ++ N
Sbjct: 85 ELLTQIDRLNTERGVHGILVQLPLPKQ--INETRVLERIHPQKDVDGFHSEN 134
Score = 46.0 bits (104), Expect = 3e-04
Identities = 25/74 (33%), Positives = 44/74 (59%)
Frame = +3
Query: 36 QIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIG 215
+II G +A S+ +++ +V R +++ G EP LA+V VG S VY+R K++ A +G
Sbjct: 12 KIIDGKAIAQSVLEEVKLEVERYKAQ--GIEPCLAVVLVGEDPASQVYVRNKVQKAAFVG 69
Query: 216 IAAEHIRLPRDITK 257
I + R D+++
Sbjct: 70 IRSLEFRFDADLSE 83
>UniRef50_Q4A6B1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma synoviae 53|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Mycoplasma synoviae (strain 53)
Length = 278
Score = 46.8 bits (106), Expect = 2e-04
Identities = 29/74 (39%), Positives = 43/74 (58%)
Frame = +3
Query: 36 QIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIG 215
+I+SG E A E DL+Q L +LAI+QVG + +SN Y+ KLK A++IG
Sbjct: 2 KILSGREKA---EQDLKQLKKELDELNLNRPIKLAIIQVGDKMESNRYVEQKLKKAKEIG 58
Query: 216 IAAEHIRLPRDITK 257
I A+ + +IT+
Sbjct: 59 IEAKCFKFDENITQ 72
Score = 31.9 bits (69), Expect = 5.4
Identities = 19/52 (36%), Positives = 30/52 (57%)
Frame = +2
Query: 263 LLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINE 418
LL + +NE+ GI++Q+PL + + DAV +KD+DGL+ NE
Sbjct: 75 LLLAMDEINENWD--GILIQLPLPKH--LPKEVILDAVPYEKDIDGLSHRNE 122
>UniRef50_Q1II76 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Acidobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Acidobacteria bacterium (strain Ellin345)
Length = 307
Score = 46.8 bits (106), Expect = 2e-04
Identities = 22/52 (42%), Positives = 34/52 (65%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
+LL + SLN + GI+VQ+PL +D+ ++ AVSP+KDVDG + +N
Sbjct: 77 DLLQLVESLNRRNDIDGILVQLPLPKQ--VDSKKILLAVSPEKDVDGFHPMN 126
>UniRef50_UPI00015B49ED Cluster: PREDICTED: similar to putative
glyoxylate reductase/hydroxypyruvate reductase; n=1;
Nasonia vitripennis|Rep: PREDICTED: similar to putative
glyoxylate reductase/hydroxypyruvate reductase - Nasonia
vitripennis
Length = 699
Score = 46.4 bits (105), Expect = 2e-04
Identities = 23/52 (44%), Positives = 34/52 (65%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
ELL ++ LN+ P+V G++VQ+P+ +H I V AV+P KDVDG + N
Sbjct: 103 ELLHEVQKLNDDPTVDGLLVQLPV-PEH-ISEREVCQAVTPTKDVDGFHLSN 152
Score = 41.1 bits (92), Expect = 0.009
Identities = 23/75 (30%), Positives = 38/75 (50%)
Frame = +3
Query: 33 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 212
A II G VA + +++ +V + P+L + VG S Y+ K+KAA+ +
Sbjct: 28 AAIIDGNGVADQVLEEVKAEVDEMTRNGEK-RPKLIAILVGNNPASKAYVGRKVKAAKTV 86
Query: 213 GIAAEHIRLPRDITK 257
GI +E +R IT+
Sbjct: 87 GIESETLRFEDSITQ 101
>UniRef50_Q6BNW9 Cluster: Debaryomyces hansenii chromosome E of
strain CBS767 of Debaryomyces hansenii; n=2;
Debaryomyces hansenii|Rep: Debaryomyces hansenii
chromosome E of strain CBS767 of Debaryomyces hansenii -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 276
Score = 46.4 bits (105), Expect = 2e-04
Identities = 19/45 (42%), Positives = 30/45 (66%)
Frame = +3
Query: 123 FEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITK 257
F P L I+QVGGR DS+ Y++ KLKAA+ I + ++ D+++
Sbjct: 74 FRPNLTIIQVGGRPDSSAYVKAKLKAAKSSNILSSLLKFDEDMSE 118
Score = 42.3 bits (95), Expect = 0.004
Identities = 20/52 (38%), Positives = 33/52 (63%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
+LL +I LN+ P V+G+++Q+PL + +T+AV+ +KDVDG N
Sbjct: 120 DLLEEIDRLNKDPKVNGLLIQLPLPKH--FNETLITNAVATEKDVDGFARYN 169
>UniRef50_Q9KQQ6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=44; Gammaproteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Vibrio cholerae
Length = 286
Score = 46.4 bits (105), Expect = 2e-04
Identities = 20/51 (39%), Positives = 33/51 (64%)
Frame = +2
Query: 263 LLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
LL+ + LN P + GI+VQ+PL + +D +V +++ P+KDVDG + N
Sbjct: 79 LLSLVEELNNDPQIDGILVQLPLPA--GMDTTKVLESIHPEKDVDGFHPYN 127
>UniRef50_Q3AYX2 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=36; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Synechococcus sp. (strain CC9902)
Length = 293
Score = 46.4 bits (105), Expect = 2e-04
Identities = 22/52 (42%), Positives = 33/52 (63%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
E+L+ I LN P V GI++Q+PL +D + A+ P+KD DGL+T+N
Sbjct: 77 EVLSTIQQLNADPRVDGILLQLPL--PEGLDEGPLLMAIDPEKDADGLHTLN 126
Score = 39.1 bits (87), Expect = 0.036
Identities = 24/71 (33%), Positives = 40/71 (56%)
Frame = +3
Query: 30 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEK 209
MA + G +A ++E+ L+ Q+ + +G P LA+++VG S VY+ K KA +
Sbjct: 1 MALRLDGKALAKAVESRLQAQIESNLPQ-AGRPPGLAVLRVGDDPASAVYVANKEKACAR 59
Query: 210 IGIAAEHIRLP 242
IG+A+ LP
Sbjct: 60 IGVASYGAHLP 70
>UniRef50_Q5FJG5 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Firmicutes|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Lactobacillus acidophilus
Length = 283
Score = 46.4 bits (105), Expect = 2e-04
Identities = 23/73 (31%), Positives = 40/73 (54%)
Frame = +3
Query: 30 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEK 209
M +I+ G VA + L+++V L+ + G P ++ +G S +Y+R K + AEK
Sbjct: 1 MGKILDGKFVANLLGEKLKEKVKDLKEE--GITPHFCVINIGDDPASKIYVRTKKRRAEK 58
Query: 210 IGIAAEHIRLPRD 248
+GI + +LP D
Sbjct: 59 MGIIQDIYQLPAD 71
Score = 45.2 bits (102), Expect = 5e-04
Identities = 20/47 (42%), Positives = 30/47 (63%)
Frame = +2
Query: 275 ITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
I LNE P ++G++VQ+P + IDA + + + P+KDVDGL N
Sbjct: 81 IDKLNEDPDINGVMVQLP--APEQIDADELLERIDPNKDVDGLTPSN 125
>UniRef50_UPI00006CB712 Cluster: tetrahydrofolate
dehydrogenase/cyclohydrolase, NAD(P)-binding domain;
n=1; Tetrahymena thermophila SB210|Rep: tetrahydrofolate
dehydrogenase/cyclohydrolase, NAD(P)-binding domain -
Tetrahymena thermophila SB210
Length = 377
Score = 46.0 bits (104), Expect = 3e-04
Identities = 21/78 (26%), Positives = 47/78 (60%)
Frame = +3
Query: 24 AKMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAA 203
A+ +++G +++ + +++++ R+ + EP+LAI+ VG DS Y+ +K +A
Sbjct: 25 AEQPILVNGNKISKDVLQKVKERILRVNIR----EPKLAIILVGNAADSISYVSVKQRAC 80
Query: 204 EKIGIAAEHIRLPRDITK 257
+++G+ +E I LP T+
Sbjct: 81 KRVGVQSELIHLPETTTQ 98
Score = 31.1 bits (67), Expect = 9.5
Identities = 16/48 (33%), Positives = 25/48 (52%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGL 403
E++ + LN+ V I+ Q+P + I V + + P KDVDGL
Sbjct: 100 EVIQIVEDLNKREDVDSILTQLPFPAQ--ISKTIVINQIEPSKDVDGL 145
>UniRef50_Q4RT28 Cluster: Chromosome 12 SCAF14999, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 12 SCAF14999, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 342
Score = 45.6 bits (103), Expect = 4e-04
Identities = 24/52 (46%), Positives = 33/52 (63%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
ELL I LN V G++VQ+PL +H ID + +AV+P KDVDG + +N
Sbjct: 105 ELLDLIDKLNTDHRVDGLLVQLPLP-EH-IDERTICNAVAPTKDVDGFHVVN 154
>UniRef50_Q74J95 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Lactobacillus|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Lactobacillus johnsonii
Length = 283
Score = 45.6 bits (103), Expect = 4e-04
Identities = 19/52 (36%), Positives = 34/52 (65%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
E+L I N+ P++H I++Q+PL ++ + +A++P+KDVDG N+ N
Sbjct: 76 EVLQAIHHYNDDPTIHAILIQLPLPKH--LNQTELIEAIAPEKDVDGFNSKN 125
Score = 44.8 bits (101), Expect = 7e-04
Identities = 22/76 (28%), Positives = 44/76 (57%)
Frame = +3
Query: 30 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEK 209
M II+G ++A + + + +V +L+ + G P + ++ VG S +Y R K K AEK
Sbjct: 1 MTNIINGRQIAKQLNQETKTRVDKLKEE--GIIPGIVVILVGDDPASVIYTRNKQKNAEK 58
Query: 210 IGIAAEHIRLPRDITK 257
+G+ + + P+D+++
Sbjct: 59 LGMKSILRKFPKDVSQ 74
>UniRef50_P47259 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Mycoplasma|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma genitalium
Length = 273
Score = 45.2 bits (102), Expect = 5e-04
Identities = 24/50 (48%), Positives = 35/50 (70%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 409
EL+ KI SLN +V GII+Q+P+ H +D + + +A++P KDVDGL T
Sbjct: 68 ELIEKIISLNHDVNVTGIILQLPV-YPH-LDKNSLLEAINPLKDVDGLTT 115
>UniRef50_Q6MI74 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Bdellovibrio bacteriovorus|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Bdellovibrio
bacteriovorus
Length = 288
Score = 45.2 bits (102), Expect = 5e-04
Identities = 26/76 (34%), Positives = 43/76 (56%)
Frame = +3
Query: 30 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEK 209
M I+ G EVA + L +V + + + G P+L++V VG + S+VY++ K A EK
Sbjct: 1 MVLILDGKEVAKEVRASLVPRVAKFKETY-GRAPQLSVVIVGDDKASHVYVKNKKIACEK 59
Query: 210 IGIAAEHIRLPRDITK 257
IG+ + LP + T+
Sbjct: 60 IGMTSTIHTLPAETTQ 75
Score = 33.1 bits (72), Expect = 2.4
Identities = 19/48 (39%), Positives = 25/48 (52%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGL 403
EL ++ LN V GI+VQ PL + + V VS +KD DGL
Sbjct: 77 ELNQILSKLNNDNGVDGILVQFPLPKH--LSSDEVLKLVSAEKDADGL 122
>UniRef50_Q0SFQ8 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Actinomycetales|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rhodococcus sp. (strain RHA1)
Length = 297
Score = 45.2 bits (102), Expect = 5e-04
Identities = 21/52 (40%), Positives = 32/52 (61%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
++ + + L P VHGII+Q PL +DA R +A++P KDVDG N ++
Sbjct: 76 QIRSTLVELGHDPDVHGIILQTPLPDGTDLDALR--EAINPAKDVDGANPVS 125
Score = 37.9 bits (84), Expect = 0.083
Identities = 23/70 (32%), Positives = 34/70 (48%)
Frame = +3
Query: 30 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEK 209
M + + G E+A SI ND L G P+LA+VQ E + Y+R AA++
Sbjct: 1 MTRSLGGAELATSIRNDASVAAAALNDL--GTRPKLAVVQATDDESTAWYVRSIASAAKR 58
Query: 210 IGIAAEHIRL 239
GI + + L
Sbjct: 59 TGILCDIVDL 68
>UniRef50_UPI000065DF90 Cluster: methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 2-like; n=1; Takifugu
rubripes|Rep: methylenetetrahydrofolate dehydrogenase
(NADP+ dependent) 2-like - Takifugu rubripes
Length = 400
Score = 44.8 bits (101), Expect = 7e-04
Identities = 22/77 (28%), Positives = 44/77 (57%)
Frame = +3
Query: 27 KMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAE 206
+ A +ISG E+A I+ ++++ V L ++ P L +V VG S Y++ K +AA
Sbjct: 5 RAAVVISGTELARQIQREIQRDVEELVAQ-GNMRPHLGVVLVGEDPASRTYVKNKTRAAS 63
Query: 207 KIGIAAEHIRLPRDITK 257
+GI+++ + P +++
Sbjct: 64 ILGISSDTVVRPSSVSQ 80
Score = 43.6 bits (98), Expect = 0.002
Identities = 22/52 (42%), Positives = 34/52 (65%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
ELL I +N V G++VQ+PL +H I+ V +A++P+KDVDG + +N
Sbjct: 82 ELLELIDKMNRDWRVSGLLVQLPLP-EH-INERAVCNAIAPEKDVDGFHIVN 131
>UniRef50_Q4S6Y9 Cluster: Chromosome 14 SCAF14723, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 14 SCAF14723, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 1066
Score = 44.8 bits (101), Expect = 7e-04
Identities = 21/53 (39%), Positives = 33/53 (62%)
Frame = +2
Query: 257 IELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
IE++ ++ L+E P VHG+ + +P A RV A+ P+KDVDGL+ +N
Sbjct: 63 IEIVTEVLKLSEDPGVHGLYLHLP----QASLTSRVLTALKPEKDVDGLSDLN 111
>UniRef50_A5IXS7 Cluster: FolD bifunctional protein; n=1; Mycoplasma
agalactiae|Rep: FolD bifunctional protein - Mycoplasma
agalactiae
Length = 286
Score = 44.4 bits (100), Expect = 0.001
Identities = 25/79 (31%), Positives = 48/79 (60%)
Frame = +3
Query: 39 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGI 218
I++G +A +L+++ + +K G +P L+I+QVG S++YI+ K+K AE++G+
Sbjct: 3 ILNGKIIAEERTVELKKEFEEI-TKLIGRQPVLSIIQVGDNPASSLYIKNKIKKAEELGV 61
Query: 219 AAEHIRLPRDITK*SC*QK 275
A + DI++ S +K
Sbjct: 62 KATLYKFDEDISQNSLLKK 80
>UniRef50_A7DNA7 Cluster: Methylenetetrahydrofolate dehydrogenase
(NADP(+)); n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Methylenetetrahydrofolate dehydrogenase
(NADP(+)) - Candidatus Nitrosopumilus maritimus SCM1
Length = 287
Score = 44.4 bits (100), Expect = 0.001
Identities = 23/47 (48%), Positives = 28/47 (59%)
Frame = +2
Query: 275 ITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
I +LN SVHGI+VQ+PL +D T +SP KDVDGL N
Sbjct: 82 IENLNNDNSVHGILVQLPLPEQ--LDEFTTTSRISPLKDVDGLTPHN 126
Score = 39.5 bits (88), Expect = 0.027
Identities = 22/72 (30%), Positives = 40/72 (55%)
Frame = +3
Query: 42 ISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIA 221
I G ++ S+++ +++ V L+++ G P LA V VG S Y+R K +A E++GI
Sbjct: 6 IDGKVISQSVKDRVKKAVEELKNQ--GINPCLATVLVGDNPASATYVRNKHRACEEVGIT 63
Query: 222 AEHIRLPRDITK 257
+ +L T+
Sbjct: 64 TKDHKLDASTTQ 75
>UniRef50_Q14NV1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Spiroplasma citri|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Spiroplasma citri
Length = 286
Score = 44.4 bits (100), Expect = 0.001
Identities = 23/74 (31%), Positives = 42/74 (56%)
Frame = +3
Query: 36 QIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIG 215
+II G V+ I+ + +Q+ ++++K P L I+Q+G + S YI+ K A EK+G
Sbjct: 5 KIIDGKMVSELIKAKITEQILKIKAKKQRV-PALTIIQIGNNKASTTYIKNKKIACEKVG 63
Query: 216 IAAEHIRLPRDITK 257
+ + + P IT+
Sbjct: 64 VTCKVLNYPDIITE 77
>UniRef50_A5CF58 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Orientia tsutsugamushi Boryong|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Orientia tsutsugamushi
(strain Boryong) (Rickettsia tsutsugamushi)
Length = 301
Score = 44.4 bits (100), Expect = 0.001
Identities = 25/52 (48%), Positives = 32/52 (61%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
+L + I LN +VHGIIVQ+PL IDA ++ + KDVDGLN IN
Sbjct: 77 KLFSVIDDLNCDSTVHGIIVQLPLPPH--IDALKLFARIDSRKDVDGLNPIN 126
Score = 32.7 bits (71), Expect = 3.1
Identities = 20/70 (28%), Positives = 37/70 (52%)
Frame = +3
Query: 30 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEK 209
M I+ G ++A + + + L+ K+ +L I+ VG + S +Y+ K+ A+
Sbjct: 1 MTVIMDGKKLAELRLIETKNDLLALKDKYQ-ITVKLVIILVGNNDASLIYVNNKVAKAKA 59
Query: 210 IGIAAEHIRL 239
IG+ +E IRL
Sbjct: 60 IGMDSEIIRL 69
>UniRef50_Q5SJ94 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermus thermophilus|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermus thermophilus (strain HB8 / ATCC
27634 / DSM 579)
Length = 282
Score = 44.0 bits (99), Expect = 0.001
Identities = 23/51 (45%), Positives = 31/51 (60%)
Frame = +2
Query: 263 LLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
LL +I +LN V GI+VQ+PL I RV +A+ P KDVDG + +N
Sbjct: 75 LLERIAALNADEEVDGILVQLPLPPH--IRTQRVLEAIHPLKDVDGFHPLN 123
Score = 39.5 bits (88), Expect = 0.027
Identities = 24/73 (32%), Positives = 40/73 (54%)
Frame = +3
Query: 33 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 212
AQ++SG E A ++ ++R RLRS F P L ++++G S Y+R+K K A +
Sbjct: 3 AQVLSGHEAAEAVYEEIR---ARLRSL--SFTPSLRVIRLGEDPASVAYVRLKDKRARAL 57
Query: 213 GIAAEHIRLPRDI 251
G ++ P D+
Sbjct: 58 GYRSQVEVYPEDL 70
>UniRef50_Q3YRE3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Proteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Ehrlichia canis (strain Jake)
Length = 300
Score = 44.0 bits (99), Expect = 0.001
Identities = 21/51 (41%), Positives = 31/51 (60%)
Frame = +2
Query: 263 LLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
L+ KI LN +VHGI+VQ+P+ ID + + + + P KDVDG + N
Sbjct: 79 LIDKIHELNNDDNVHGILVQLPVPKH--IDKNLIINTIDPRKDVDGFHNDN 127
>UniRef50_Q97HC9 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; Clostridium|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Clostridium acetobutylicum
Length = 278
Score = 44.0 bits (99), Expect = 0.001
Identities = 22/52 (42%), Positives = 31/52 (59%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
EL+ I LN +HGI++Q+PL + IDA VT + +KD+D L IN
Sbjct: 77 ELIKLIEGLNVDNKIHGIMLQLPLPNH--IDAKLVTSKIDANKDIDSLTDIN 126
>UniRef50_P56467 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Helicobacter pylori (Campylobacter pylori)
Length = 290
Score = 43.6 bits (98), Expect = 0.002
Identities = 22/73 (30%), Positives = 44/73 (60%)
Frame = +3
Query: 39 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGI 218
++ G +A +IE DL+ ++ + ++ + P+LA++ VG S Y+ MK+KA E++G+
Sbjct: 8 LLDGQALADNIEKDLKHKIQIITAQ-THKRPKLAVILVGKDPASITYVNMKIKACERVGM 66
Query: 219 AAEHIRLPRDITK 257
+ L +IT+
Sbjct: 67 DFDLKTLQENITE 79
Score = 42.7 bits (96), Expect = 0.003
Identities = 19/52 (36%), Positives = 32/52 (61%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
+LL+ I N ++ G++VQ+PL ID + +A+ P+KDVDG + +N
Sbjct: 81 KLLSLIKDYNTDQNISGVLVQLPLPRH--IDTKMILEAIDPNKDVDGFHPLN 130
>UniRef50_Q4FTX6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=24; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Psychrobacter arcticum
Length = 295
Score = 42.7 bits (96), Expect = 0.003
Identities = 21/51 (41%), Positives = 31/51 (60%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTI 412
EL+AKI LN +P VHGI++Q P+ + ID + + KDVDG+ +
Sbjct: 89 ELMAKIDELNNNPDVHGILLQHPVPAH--IDERACFEQIDLAKDVDGVTCL 137
>UniRef50_Q2UUX1 Cluster: RIB40 genomic DNA, SC009; n=1; Aspergillus
oryzae|Rep: RIB40 genomic DNA, SC009 - Aspergillus
oryzae
Length = 275
Score = 42.3 bits (95), Expect = 0.004
Identities = 26/71 (36%), Positives = 37/71 (52%), Gaps = 5/71 (7%)
Frame = +2
Query: 209 NWYRRRTYPLTKGHH*IELLAK-----ITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDA 373
NW R+ + H ++L K I ++N + SVHGIIV P+ D D +
Sbjct: 51 NWTRKTCQEIGVHFHLMKLSPKNVATYIRAINANNSVHGIIVYYPIFGDRRDD--EIRQL 108
Query: 374 VSPDKDVDGLN 406
V+P KDV+GLN
Sbjct: 109 VAPSKDVEGLN 119
>UniRef50_A0JTZ0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=51; Actinobacteria (class)|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Arthrobacter sp. (strain FB24)
Length = 302
Score = 41.9 bits (94), Expect = 0.005
Identities = 20/49 (40%), Positives = 27/49 (55%)
Frame = +2
Query: 269 AKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
A I LN P+ HG IVQ+PL +D + + + P KD DGL+ N
Sbjct: 82 ALIDELNADPACHGYIVQLPLPKH--LDTDAILERIDPAKDADGLHPTN 128
>UniRef50_Q3A1Q7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Pelobacter carbinolicus (strain DSM 2380 / Gra Bd 1)
Length = 290
Score = 41.1 bits (92), Expect = 0.009
Identities = 19/52 (36%), Positives = 29/52 (55%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
+LLA + N+SP V I+Q PL D + + + P+KD DGL+ +N
Sbjct: 77 DLLAAVRDFNDSPDVDAYIIQYPLPK--GFDFNEALNLMLPEKDADGLHPVN 126
>UniRef50_UPI0000DB7ABF Cluster: PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor; n=1; Apis mellifera|Rep:
PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor - Apis mellifera
Length = 407
Score = 40.3 bits (90), Expect = 0.016
Identities = 24/69 (34%), Positives = 37/69 (53%)
Frame = +3
Query: 33 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 212
A II G ++A I+N+L+ V + + P+L ++VG S +Y+ K+KAA I
Sbjct: 110 AIIIDGKKIANKIQNELKITVDNWIND-NKKRPKLVAIKVGNNPASKIYVEKKIKAANFI 168
Query: 213 GIAAEHIRL 239
GI I L
Sbjct: 169 GIENYTIHL 177
Score = 38.7 bits (86), Expect = 0.047
Identities = 19/52 (36%), Positives = 32/52 (61%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
+++ +I +LN+ +V GI+VQ+PL ++ V A+ P KDVDG + N
Sbjct: 185 DIINEIDNLNKDKTVDGILVQLPLIKH--MNEQEVCQAIIPSKDVDGFHLEN 234
>UniRef50_Q0AWX5 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Syntrophomonas wolfei subsp. wolfei str.
Goettingen|Rep: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Syntrophomonas wolfei subsp. wolfei (strain Goettingen)
Length = 272
Score = 40.3 bits (90), Expect = 0.016
Identities = 20/52 (38%), Positives = 33/52 (63%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
ELL I LN S + GI++Q PL + +++A + +A+ DKDV+G++ N
Sbjct: 69 ELLKTIGDLNNSSEITGIMLQTPLPA--SLNASHLVNAIDFDKDVEGIHNYN 118
Score = 36.3 bits (80), Expect = 0.25
Identities = 20/56 (35%), Positives = 31/56 (55%), Gaps = 1/56 (1%)
Frame = +3
Query: 78 DLRQQVT-RLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLP 242
D+R+Q+ R+R + LAI++VG S Y+R K AE+ G+ E + LP
Sbjct: 7 DIREQIKERVRQSAEEVKMGLAIIRVGDDPSSMAYVRGIRKFAEETGVKVEIVNLP 62
>UniRef50_Q979W3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermoplasma|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermoplasma volcanium
Length = 281
Score = 39.9 bits (89), Expect = 0.021
Identities = 22/74 (29%), Positives = 41/74 (55%)
Frame = +3
Query: 36 QIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIG 215
+++ G E+A +L++++ ++ G PRL ++QVG + +Y R K+K +KIG
Sbjct: 4 KLLKGEEIAEKKAEELKERIEKM-----GVSPRLVLLQVGNYSAATIYARAKIKRGKKIG 58
Query: 216 IAAEHIRLPRDITK 257
A + D+TK
Sbjct: 59 -ADVVLEKYEDLTK 71
>UniRef50_A3PVV6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; Actinobacteridae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycobacterium sp. (strain JLS)
Length = 288
Score = 39.9 bits (89), Expect = 0.021
Identities = 21/52 (40%), Positives = 28/52 (53%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
EL A I LN +P G IVQ+PL +D + + + P KD DGL+ N
Sbjct: 80 ELDATIDELNANPECTGYIVQLPLPKH--LDENAALERIDPGKDADGLHPTN 129
Score = 33.1 bits (72), Expect = 2.4
Identities = 21/60 (35%), Positives = 30/60 (50%)
Frame = +3
Query: 78 DLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITK 257
DL+++V L + G P L V VG S Y+R K K+GI + LP DI++
Sbjct: 21 DLKERVAALTEQ--GRTPGLGTVLVGDDPGSQAYVRGKHSDCAKVGINSIRRDLPADISQ 78
>UniRef50_Q8ZZK1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Pyrobaculum|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Pyrobaculum aerophilum
Length = 311
Score = 39.1 bits (87), Expect = 0.036
Identities = 22/53 (41%), Positives = 29/53 (54%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTINE 418
E L I SLN V G+I+Q PL +D + A+SP+KDVD L N+
Sbjct: 83 EALRLIESLNRRDDVTGVIIQKPLPP--FVDEKALFSALSPEKDVDALTPENK 133
>UniRef50_Q057D7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Enterobacteriaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Buchnera aphidicola subsp. Cinara cedri
Length = 284
Score = 39.1 bits (87), Expect = 0.036
Identities = 19/53 (35%), Positives = 32/53 (60%)
Frame = +2
Query: 257 IELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
IEL+ I LN++ + GI++Q+PL I+ ++ ++ P KDVDG + N
Sbjct: 77 IELINLIKKLNKNKCIDGILIQLPLPI--KINYLKIITSIDPKKDVDGFHPYN 127
>UniRef50_UPI00006CCCC6 Cluster: methylenetetrahydrofolate
dehydrogenase; n=1; Tetrahymena thermophila SB210|Rep:
methylenetetrahydrofolate dehydrogenase - Tetrahymena
thermophila SB210
Length = 342
Score = 37.9 bits (84), Expect = 0.083
Identities = 20/62 (32%), Positives = 33/62 (53%)
Frame = +2
Query: 218 RRRTYPLTKGHH*IELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVD 397
R Y ++ ++L+ I +LN + I+ Q+PL S ID + V + +S +KD D
Sbjct: 79 RHELYHFSEDIQEYDVLSAIDNLNRKDDIDAIMAQLPLPSH--IDKNNVINMISSEKDAD 136
Query: 398 GL 403
GL
Sbjct: 137 GL 138
Score = 35.9 bits (79), Expect = 0.33
Identities = 24/81 (29%), Positives = 40/81 (49%), Gaps = 1/81 (1%)
Frame = +3
Query: 12 TVLWAKMAQIISGIEVAGSIENDLRQQVTRLRSKWS-GFEPRLAIVQVGGREDSNVYIRM 188
T+ ++ + +G + A I + LR+++ + + +P L I+ VG S YI+
Sbjct: 9 TLRYSFSTVVFNGNKSAKKILSSLRKEIEWFQKQSDLSRKPGLGIILVGNNPASLSYIKK 68
Query: 189 KLKAAEKIGIAAEHIRLPRDI 251
KL+A E IGI E DI
Sbjct: 69 KLQACEAIGIRHELYHFSEDI 89
>UniRef50_Q7TU81 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Prochlorococcus marinus|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Prochlorococcus marinus subsp. pastoris
(strain CCMP 1378 / MED4)
Length = 298
Score = 37.1 bits (82), Expect = 0.14
Identities = 16/47 (34%), Positives = 28/47 (59%)
Frame = +2
Query: 275 ITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
+ LN ++ G+++Q+P+ D R+ ++P+KDVDGLN N
Sbjct: 82 LNKLNLDNNIDGMLLQLPISKK--FDEQRLISFINPEKDVDGLNEQN 126
>UniRef50_Q6KID0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma mobile|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma mobile
Length = 280
Score = 37.1 bits (82), Expect = 0.14
Identities = 17/44 (38%), Positives = 27/44 (61%)
Frame = +3
Query: 126 EPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITK 257
+P IVQVG SN YI+ K+ A +IG+ + I++P I++
Sbjct: 27 KPVFTIVQVGNLFSSNKYIKTKMDKALEIGVVSRLIKIPESISE 70
Score = 33.1 bits (72), Expect = 2.4
Identities = 17/42 (40%), Positives = 25/42 (59%)
Frame = +2
Query: 290 ESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
ES HG+IVQ+PL D ++ ++V KD+DGL+ N
Sbjct: 80 ESKISHGLIVQLPLPLQ--FDQSKILNSVPITKDIDGLSEKN 119
>UniRef50_Q2JCX4 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Frankia|Rep: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Frankia sp. (strain CcI3)
Length = 276
Score = 37.1 bits (82), Expect = 0.14
Identities = 19/48 (39%), Positives = 28/48 (58%)
Frame = +2
Query: 263 LLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLN 406
+L I ++ P+VHGIIVQ PL + + V + + KDVDG+N
Sbjct: 74 ILDTIDTVAADPTVHGIIVQTPLPG--GLTSREVGEHIPTAKDVDGMN 119
>UniRef50_Q54Z91 Cluster: Methylenetetrahydrofolate dehydrogenase;
n=2; Dictyostelium discoideum|Rep:
Methylenetetrahydrofolate dehydrogenase - Dictyostelium
discoideum AX4
Length = 313
Score = 36.3 bits (80), Expect = 0.25
Identities = 20/53 (37%), Positives = 31/53 (58%)
Frame = +2
Query: 257 IELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
++L I N VHGI+V P+ +D++ + D VSP KD++GL+T N
Sbjct: 78 VDLEDLIIEANNDSCVHGILVYYPVFGG-MMDSY-LQDVVSPTKDIEGLSTQN 128
>UniRef50_Q8EV80 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma penetrans|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma penetrans
Length = 282
Score = 36.3 bits (80), Expect = 0.25
Identities = 16/50 (32%), Positives = 31/50 (62%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNT 409
+L+ +I LN S+ G I+Q+PL D++ + + + +KD+DGL++
Sbjct: 73 DLIKQIHILNNDDSIDGYIIQLPLPK--GFDSNVICEHIDVNKDIDGLSS 120
Score = 35.1 bits (77), Expect = 0.58
Identities = 17/60 (28%), Positives = 36/60 (60%)
Frame = +3
Query: 39 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGI 218
I++ I++A +I + + + +L+ K P +AIV++ S+ Y+ +KLK A ++G+
Sbjct: 2 IVNCIDIANNILDKFKSDLEKLKKK--KIIPHMAIVKINDDAASDKYVSIKLKKAAELGV 59
>UniRef50_A7AXK7 Cluster: Putative uncharacterized protein; n=1;
Ruminococcus gnavus ATCC 29149|Rep: Putative
uncharacterized protein - Ruminococcus gnavus ATCC 29149
Length = 276
Score = 35.9 bits (79), Expect = 0.33
Identities = 18/62 (29%), Positives = 35/62 (56%)
Frame = +3
Query: 72 ENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDI 251
+ +L++++ L K P LA++Q+ + SN YI+ K K ++IGI H+ + +
Sbjct: 16 KKELKEEIKHLDKK-----PVLAVIQIDDDQASNSYIKGKQKDCDEIGIEMRHVNIYSNT 70
Query: 252 TK 257
T+
Sbjct: 71 TE 72
>UniRef50_Q5RGD2 Cluster: Novel protein similar to vertebrate
formyltetrahydrofolate synthetase domain containing 1;
n=1; Danio rerio|Rep: Novel protein similar to
vertebrate formyltetrahydrofolate synthetase domain
containing 1 - Danio rerio (Zebrafish) (Brachydanio
rerio)
Length = 217
Score = 35.5 bits (78), Expect = 0.44
Identities = 17/52 (32%), Positives = 29/52 (55%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
E++ ++ LN+ VHGI + +P + V +A+ P KDVDG+ +N
Sbjct: 63 EVIEEVLRLNKDSRVHGIFLHLP----QTFLSKSVRNAIKPQKDVDGVCDLN 110
>UniRef50_A5V1H2 Cluster: Methylenetetrahydrofolate dehydrogenase
(NADP(+)); n=5; Chloroflexi (class)|Rep:
Methylenetetrahydrofolate dehydrogenase (NADP(+)) -
Roseiflexus sp. RS-1
Length = 288
Score = 35.5 bits (78), Expect = 0.44
Identities = 16/47 (34%), Positives = 29/47 (61%)
Frame = +2
Query: 275 ITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
I++L+ ++HGI++ +PL +D+ R + P KDVDG++ N
Sbjct: 83 ISALSFDRTIHGILLHLPLPP--GLDSARAIAQIDPAKDVDGVHPYN 127
>UniRef50_A0DMT9 Cluster: Chromosome undetermined scaffold_57, whole
genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_57,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 309
Score = 35.5 bits (78), Expect = 0.44
Identities = 17/52 (32%), Positives = 32/52 (61%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
E++ +I SLN+ S+ GI+VQ+PL + +++ + +KD+D L+ N
Sbjct: 81 EIVHRIKSLNQKGSIDGILVQLPLPPH--LSRLEISNEIKLNKDIDCLHMAN 130
Score = 31.5 bits (68), Expect = 7.2
Identities = 16/43 (37%), Positives = 22/43 (51%)
Frame = +3
Query: 129 PRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDITK 257
P LAI+QVG S Y+R K+ E+ I E P I++
Sbjct: 37 PGLAIIQVGNNPSSLTYVRKKIALCEEHQIHHELYHFPETISQ 79
>UniRef50_A6NP56 Cluster: Uncharacterized protein ENSP00000372121;
n=5; Eutheria|Rep: Uncharacterized protein
ENSP00000372121 - Homo sapiens (Human)
Length = 200
Score = 35.5 bits (78), Expect = 0.44
Identities = 20/65 (30%), Positives = 37/65 (56%)
Frame = +3
Query: 33 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 212
A +ISG ++A I+ ++RQ+V + P L+++ VG S+ Y+ K +AA +
Sbjct: 37 AVVISGRKLAQQIKQEVRQEVEEWVAS-GDKRPHLSMILVGESSASHSYVLNKTRAAADV 95
Query: 213 GIAAE 227
GI ++
Sbjct: 96 GINSD 100
>UniRef50_O51057 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Borrelia burgdorferi group|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Borrelia burgdorferi
(Lyme disease spirochete)
Length = 308
Score = 35.5 bits (78), Expect = 0.44
Identities = 19/52 (36%), Positives = 32/52 (61%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
++L I N++ S GIIVQ+PL +D + + +++ KDVDGL+ +N
Sbjct: 82 DILEVIDRENKNLSTDGIIVQLPLLK--GMDLNSILNSIVYSKDVDGLSFVN 131
>UniRef50_UPI0000D9D4E1 Cluster: PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor; n=2; Catarrhini|Rep: PREDICTED:
similar to Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor -
Macaca mulatta
Length = 111
Score = 35.1 bits (77), Expect = 0.58
Identities = 19/62 (30%), Positives = 35/62 (56%)
Frame = +3
Query: 33 AQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKI 212
A +ISG ++A I+ ++RQ+V + P L+++ VG S+ Y+ K +AA +
Sbjct: 37 AVVISGRKLAQEIKQEVRQEVEEWVAS-GNKRPHLSVILVGENPASHSYVLNKTRAAADV 95
Query: 213 GI 218
G+
Sbjct: 96 GM 97
>UniRef50_Q8KEH0 Cluster: Methylenetetrahydrofolate dehydrogenase;
n=1; Chlorobaculum tepidum|Rep:
Methylenetetrahydrofolate dehydrogenase - Chlorobium
tepidum
Length = 296
Score = 35.1 bits (77), Expect = 0.58
Identities = 19/46 (41%), Positives = 27/46 (58%)
Frame = +2
Query: 269 AKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLN 406
A + + N +VHGI V P+ D DA + D +SP KDV+GL+
Sbjct: 71 ATLEAANRDSAVHGIFVYYPIWGDKR-DAE-LRDLISPHKDVEGLS 114
>UniRef50_Q987T6 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Alphaproteobacteria|Rep: Bifunctional protein folD
2 [Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rhizobium loti (Mesorhizobium loti)
Length = 306
Score = 35.1 bits (77), Expect = 0.58
Identities = 18/49 (36%), Positives = 26/49 (53%)
Frame = +3
Query: 108 SKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRLPRDIT 254
+K GF P+L + VG + +VY+R + A+ GI E R P IT
Sbjct: 30 AKAEGFPPKLISITVGDTDAVDVYVRNQRAKAQLAGIDFEERRFPATIT 78
>UniRef50_Q5KEZ0 Cluster: Methylenetetrahydrofolate dehydrogenase
(NAD+), putative; n=1; Filobasidiella neoformans|Rep:
Methylenetetrahydrofolate dehydrogenase (NAD+), putative
- Cryptococcus neoformans (Filobasidiella neoformans)
Length = 367
Score = 34.3 bits (75), Expect = 1.0
Identities = 20/50 (40%), Positives = 27/50 (54%)
Frame = +2
Query: 257 IELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLN 406
IE+ I NE P V G++V P+ D + + VSP KDV+GLN
Sbjct: 84 IEVEEAILEANEDPEVDGMMVYYPIYGGRQ-DQY-LQSVVSPQKDVEGLN 131
>UniRef50_Q9RW02 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Deinococcus|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Deinococcus radiodurans
Length = 299
Score = 34.3 bits (75), Expect = 1.0
Identities = 15/47 (31%), Positives = 29/47 (61%)
Frame = +2
Query: 275 ITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
+ L+ P+VHGI++++PL + +DA ++ KD++GL+ N
Sbjct: 93 LRELSADPAVHGIVLELPLAA--GLDADAALLHIAARKDIEGLSPAN 137
Score = 33.9 bits (74), Expect = 1.3
Identities = 15/33 (45%), Positives = 21/33 (63%)
Frame = +3
Query: 123 FEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIA 221
FEP+L V E S VY++ K K A+K+G+A
Sbjct: 42 FEPQLVSVLASDDEASQVYVQSKAKRAKKLGVA 74
>UniRef50_A6FY71 Cluster: Histone deacetylase superfamily protein;
n=1; Plesiocystis pacifica SIR-1|Rep: Histone
deacetylase superfamily protein - Plesiocystis pacifica
SIR-1
Length = 623
Score = 33.5 bits (73), Expect = 1.8
Identities = 25/72 (34%), Positives = 36/72 (50%), Gaps = 5/72 (6%)
Frame = +3
Query: 48 GIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDS-NVYIRMKLKAAEKIGIAA 224
G +E L + R + G+EPR+ +V GGR DS +R+ +A + G AA
Sbjct: 383 GYYTLSGVELGLERYGLLARLRDLGYEPRVEMVVDGGRRDSAGDTVRVWGRAQTREGSAA 442
Query: 225 EHI----RLPRD 248
EH+ RL RD
Sbjct: 443 EHLLVEARLSRD 454
>UniRef50_A0C3Q0 Cluster: Chromosome undetermined scaffold_147,
whole genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_147,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 404
Score = 33.5 bits (73), Expect = 1.8
Identities = 23/67 (34%), Positives = 35/67 (52%)
Frame = +3
Query: 27 KMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAE 206
K+ I +G ++A +I LR +T S +P+L I VG S Y+ KLKA +
Sbjct: 115 KLKMIFNGNQLANTILKTLR--IT------SEIKPKLGICLVGDSPASKSYVNRKLKACQ 166
Query: 207 KIGIAAE 227
+I + AE
Sbjct: 167 EINVDAE 173
>UniRef50_Q8RDM4 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Fusobacterium nucleatum|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Fusobacterium nucleatum subsp. nucleatum
Length = 283
Score = 33.5 bits (73), Expect = 1.8
Identities = 19/51 (37%), Positives = 28/51 (54%)
Frame = +2
Query: 263 LLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
LL I LN+ V GI++ +PL I+A +V +++ KDVDG N
Sbjct: 76 LLNLIDKLNKDTEVDGIMINLPLPPQ--INATKVLNSIKLIKDVDGFKAEN 124
Score = 32.3 bits (70), Expect = 4.1
Identities = 16/73 (21%), Positives = 38/73 (52%)
Frame = +3
Query: 39 IISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGI 218
++ G E+A I+ ++ ++ ++ K P +A + VG S VY+ ++K+ + +GI
Sbjct: 2 LMDGKELARDIKVKIKAEIDNIK-KIHNINPMVATILVGDDPASQVYLNSQVKSYQDLGI 60
Query: 219 AAEHIRLPRDITK 257
+ +I++
Sbjct: 61 GVQKYFFSEEISE 73
>UniRef50_Q4QBW1 Cluster: Methylenetetrahydrofolate
dehydrogenase-like protein; n=2; Leishmania|Rep:
Methylenetetrahydrofolate dehydrogenase-like protein -
Leishmania major
Length = 207
Score = 32.7 bits (71), Expect = 3.1
Identities = 17/53 (32%), Positives = 29/53 (54%)
Frame = +2
Query: 257 IELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
IEL + ++N+ V +++Q+PL + V + P KDVDGL+ +N
Sbjct: 102 IELHRTLAAVNDDVEVDAVLLQLPLPPHQRTRSALVH--IHPGKDVDGLHPLN 152
>UniRef50_Q9X288 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Thermotogaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermotoga maritima
Length = 271
Score = 32.7 bits (71), Expect = 3.1
Identities = 22/66 (33%), Positives = 36/66 (54%), Gaps = 1/66 (1%)
Frame = +3
Query: 57 VAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIR 236
+A SIE +++V +L GF P+L V + Y++ + K AEK+GIA E +
Sbjct: 8 IARSIEERTKERVEKL-----GFTPKLVSVACTDDPSALSYLKSQRKKAEKLGIAFEIMN 62
Query: 237 L-PRDI 251
+ P +I
Sbjct: 63 VSPEEI 68
Score = 31.9 bits (69), Expect = 5.4
Identities = 15/52 (28%), Positives = 27/52 (51%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVSPDKDVDGLNTIN 415
E+++ + L SV+G+ V P +D + +V +KDV+G+N N
Sbjct: 67 EIVSTLKKLGSDESVNGVFVARPFPL--GLDEKEILSSVPVEKDVEGVNPAN 116
>UniRef50_Q98QV3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma pulmonis|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma pulmonis
Length = 272
Score = 32.7 bits (71), Expect = 3.1
Identities = 17/56 (30%), Positives = 34/56 (60%), Gaps = 3/56 (5%)
Frame = +3
Query: 69 IENDLRQ-QVTRLRSKWSGFEPRL--AIVQVGGREDSNVYIRMKLKAAEKIGIAAE 227
+ N+L Q + L+ K+S + ++ AIV +G S +Y++ K++ A+ IG+ A+
Sbjct: 6 LSNELVQIKRAELKEKFSKLDQKVKFAIVLIGDNASSKIYVKKKIEFAQDIGVEAK 61
>UniRef50_Q1NQA0 Cluster: 4-diphosphocytidyl-2C-methyl-D-erythritol
kinase; n=1; delta proteobacterium MLMS-1|Rep:
4-diphosphocytidyl-2C-methyl-D-erythritol kinase - delta
proteobacterium MLMS-1
Length = 297
Score = 32.3 bits (70), Expect = 4.1
Identities = 21/60 (35%), Positives = 32/60 (53%), Gaps = 1/60 (1%)
Frame = -2
Query: 272 LLTALFSDVPW*ADMFGGDTNFLSCLQLHPDVDVGVLAPAXLHDGKPGLEAR-PF*TQPR 96
L +L+ +P A + GG ++ + L+ + GVL+PA LH GL A PF QP+
Sbjct: 93 LAISLYKKIPTAAGLGGGSSDAAAVLRGLQGLHPGVLSPAQLHQLARGLGADVPFFLQPQ 152
>UniRef50_Q0A579 Cluster: Putative uncharacterized protein; n=1;
Alkalilimnicola ehrlichei MLHE-1|Rep: Putative
uncharacterized protein - Alkalilimnicola ehrlichei
(strain MLHE-1)
Length = 403
Score = 32.3 bits (70), Expect = 4.1
Identities = 20/63 (31%), Positives = 33/63 (52%)
Frame = +3
Query: 60 AGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEKIGIAAEHIRL 239
AG LR+Q+ LR++ GFE L ++G R ++N ++ +AA +A +R
Sbjct: 139 AGDALGTLREQLDELRARQGGFEEGLE--RLGARAEANRENWIRSEAAYLATVAVHRMRF 196
Query: 240 PRD 248
RD
Sbjct: 197 HRD 199
>UniRef50_UPI00015B4B54 Cluster: PREDICTED: similar to myosin; n=1;
Nasonia vitripennis|Rep: PREDICTED: similar to myosin -
Nasonia vitripennis
Length = 2257
Score = 31.9 bits (69), Expect = 5.4
Identities = 15/43 (34%), Positives = 25/43 (58%)
Frame = +1
Query: 199 QLRKLVSPPNISAYQGTSLNRAVSKNHESERISFRSRHHCSNA 327
Q++KL+SP S + T LN+ S+NH + ++ + H NA
Sbjct: 1000 QIKKLISPGAQSEPRKTILNKRHSQNHNNHQVHQQQNGHDQNA 1042
>UniRef50_Q9KF36 Cluster: BH0650 protein; n=1; Bacillus
halodurans|Rep: BH0650 protein - Bacillus halodurans
Length = 392
Score = 31.5 bits (68), Expect = 7.2
Identities = 19/47 (40%), Positives = 27/47 (57%), Gaps = 1/47 (2%)
Frame = +2
Query: 281 SLNESPSVHGIIVQMPLDSDHAIDAHRVTDAVS-PDKDVDGLNTINE 418
S N+ P V + + P DS I + V AV+ PDK++ GL +INE
Sbjct: 232 SFNDIPIVIALFREQPRDS--VIPGNFVATAVAEPDKELSGLQSINE 276
>UniRef50_Q016N9 Cluster: 5'-3' exoribonuclease 1; n=2;
Ostreococcus|Rep: 5'-3' exoribonuclease 1 - Ostreococcus
tauri
Length = 1418
Score = 31.5 bits (68), Expect = 7.2
Identities = 16/41 (39%), Positives = 25/41 (60%)
Frame = +3
Query: 9 ETVLWAKMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEP 131
E LWAK+ I+SG EV G E+ + + + R++ G+EP
Sbjct: 230 EDPLWAKVTVILSGHEVRGEGEHKIMEHIRWARTQ-PGWEP 269
>UniRef50_UPI0000585CF2 Cluster: PREDICTED: similar to beta
spectrin; n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to beta spectrin - Strongylocentrotus
purpuratus
Length = 200
Score = 31.1 bits (67), Expect = 9.5
Identities = 14/43 (32%), Positives = 24/43 (55%)
Frame = +3
Query: 6 NETVLWAKMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPR 134
+E +L K S + V G ND+ ++ RLR+ ++G +PR
Sbjct: 11 SEAILQRKHVSFQSDLPVLGQQVNDVHEEADRLRATYAGDKPR 53
>UniRef50_Q8KRD2 Cluster: Conserved protein 163; n=21;
Streptococcus|Rep: Conserved protein 163 - Streptococcus
sanguis
Length = 1465
Score = 31.1 bits (67), Expect = 9.5
Identities = 18/64 (28%), Positives = 34/64 (53%)
Frame = +3
Query: 27 KMAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAE 206
++A ++G A + N+LRQ+V L+ W+G P + +++ Y R ++AA
Sbjct: 1202 QLALPVAGANDA-QVLNNLRQEVASLQEAWTGQRPSAIPMVPEELTEADFYSRASVQAAY 1260
Query: 207 KIGI 218
K G+
Sbjct: 1261 KQGL 1264
>UniRef50_Q4VDG8 Cluster: Putative methylene tetrahydrofolate
dehydrogenase; n=1; Hyaloperonospora parasitica|Rep:
Putative methylene tetrahydrofolate dehydrogenase -
Hyaloperonospora parasitica
Length = 328
Score = 31.1 bits (67), Expect = 9.5
Identities = 20/54 (37%), Positives = 28/54 (51%), Gaps = 6/54 (11%)
Frame = +2
Query: 260 ELLAKITSLNESPSVHGIIVQMPLDSDH------AIDAHRVTDAVSPDKDVDGL 403
+LLA + NE P VHGI+V P +D + D++S KDV+GL
Sbjct: 85 DLLAALQQANEDPDVHGILVYYPCFGTFPSFFGGTMDDF-LRDSISIKKDVEGL 137
>UniRef50_Q04FB7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Leuconostocaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Oenococcus oeni (strain BAA-331 / PSU-1)
Length = 285
Score = 31.1 bits (67), Expect = 9.5
Identities = 18/63 (28%), Positives = 33/63 (52%)
Frame = +3
Query: 30 MAQIISGIEVAGSIENDLRQQVTRLRSKWSGFEPRLAIVQVGGREDSNVYIRMKLKAAEK 209
M QI+ G V+ I +++ +V + +GF +LA + E S +Y+ MK++ A
Sbjct: 1 MVQILDGRSVSKKILQEVKDKVAK-----AGFPVKLATIYNEENEGSKMYVGMKIRRATF 55
Query: 210 IGI 218
G+
Sbjct: 56 AGL 58
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 373,912,084
Number of Sequences: 1657284
Number of extensions: 6396373
Number of successful extensions: 15115
Number of sequences better than 10.0: 107
Number of HSP's better than 10.0 without gapping: 14717
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 15054
length of database: 575,637,011
effective HSP length: 93
effective length of database: 421,509,599
effective search space used: 19389441554
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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