Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= epV31039
(758 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;... 274 2e-72
UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 202 7e-51
UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 163 4e-39
UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 159 9e-38
UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulato... 157 2e-37
UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate... 155 1e-36
UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 155 1e-36
UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulato... 154 3e-36
UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p... 150 3e-35
UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella ve... 149 6e-35
UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalyti... 146 7e-34
UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8; Bilateri... 144 2e-33
UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3; Bacteria... 130 3e-29
UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 128 1e-28
UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]... 124 3e-27
UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 117 4e-25
UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9; Eut... 114 3e-24
UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 103 4e-21
UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma... 101 2e-20
UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421, ... 100 8e-20
UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependen... 91 2e-17
UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate dehydrog... 91 3e-17
UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]... 91 4e-17
UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep: C... 90 5e-17
UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68; Bacteri... 90 6e-17
UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2; Bacteria... 88 3e-16
UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3; Ricketts... 86 1e-15
UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6; E... 84 3e-15
UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8; E... 81 2e-14
UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenas... 77 5e-13
UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD] s... 76 1e-12
UniRef50_Q4UKR1 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 73 6e-12
UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6; T... 73 1e-11
UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate dehydrog... 71 4e-11
UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10; ... 71 4e-11
UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1... 69 2e-10
UniRef50_Q13FQ0 Cluster: Tartrate dehydrogenase; n=3; Proteobact... 65 2e-09
UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5; C... 63 6e-09
UniRef50_O29610 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 62 1e-08
UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;... 61 3e-08
UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 61 3e-08
UniRef50_Q2UP37 Cluster: Isocitrate/isopropylmalate dehydrogenas... 60 4e-08
UniRef50_Q9RTT2 Cluster: Isocitrate dehydrogenase, putative; n=2... 60 6e-08
UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1; S... 59 1e-07
UniRef50_Q2Q9C5 Cluster: Isocitrate dehydrogenase 3 gamma; n=8; ... 58 2e-07
UniRef50_Q4V533 Cluster: IP13250p; n=4; Drosophila melanogaster|... 58 2e-07
UniRef50_A6PN62 Cluster: 3-isopropylmalate dehydrogenase; n=1; V... 58 3e-07
UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependen... 56 9e-07
UniRef50_Q44471 Cluster: Probable tartrate dehydrogenase/decarbo... 55 2e-06
UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;... 54 3e-06
UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3; P... 54 3e-06
UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 54 3e-06
UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase; n... 54 5e-06
UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1; Ent... 53 7e-06
UniRef50_Q8XSY8 Cluster: Probable 3-isopropylmalate dehydrogenas... 52 2e-05
UniRef50_Q0X0C1 Cluster: Putative dehydrogenase; n=1; Streptomyc... 52 2e-05
UniRef50_Q0W1Q6 Cluster: 2-isopropylmalate dehydrogenase; n=5; E... 52 2e-05
UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5; T... 51 4e-05
UniRef50_Q8U299 Cluster: 3-isopropylmalate dehydrogenase 2; n=3;... 51 4e-05
UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 50 8e-05
UniRef50_P41566 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 42 1e-04
UniRef50_Q67LW7 Cluster: Tartrate dehydrogenase; n=2; Bacteria|R... 49 1e-04
UniRef50_A7GLU7 Cluster: Tartrate dehydrogenase; n=3; Bacteria|R... 49 1e-04
UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9; B... 48 2e-04
UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2; Bacillacea... 48 3e-04
UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;... 48 3e-04
UniRef50_Q58991 Cluster: Threo-isocitrate dehydrogenase [NAD]; n... 48 3e-04
UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: Leu... 47 4e-04
UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase, mitochond... 47 4e-04
UniRef50_Q6L2P9 Cluster: Isocitrate dehydrogenase [NADP]; n=2; T... 47 6e-04
UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2; Alp... 46 0.001
UniRef50_A1SM34 Cluster: 3-isopropylmalate dehydrogenase; n=1; N... 45 0.002
UniRef50_A0P1S6 Cluster: 3-isopropylmalate dehydrogenase; n=2; R... 45 0.002
UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular ... 45 0.002
UniRef50_Q8FPV5 Cluster: 3-isopropylmalate dehydrogenase; n=50; ... 43 0.007
UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 42 0.013
UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for ... 41 0.038
UniRef50_P56471 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 41 0.038
UniRef50_Q89RJ1 Cluster: 3-isopropylmalate dehydrogenase; n=7; A... 40 0.067
UniRef50_Q2VF40 Cluster: Isocitrate dehydrogenase 3 gamma subuni... 39 0.12
UniRef50_A6G3V7 Cluster: Probable 3-isopropylmalate dehydrogenas... 38 0.20
UniRef50_Q8DTG3 Cluster: 3-isopropylmalate dehydrogenase; n=41; ... 38 0.20
UniRef50_Q7UTP0 Cluster: 3-isopropylmalate dehydrogenase; n=2; B... 38 0.27
UniRef50_Q5IWY1 Cluster: Plastid 3-isopropylmalate dehydrogenase... 37 0.47
UniRef50_Q6L0K7 Cluster: 3-isopropylmalate dehydrogenase; n=2; T... 37 0.47
UniRef50_A3VUI2 Cluster: Putative dipeptidyl peptidase IV; n=1; ... 36 0.82
UniRef50_A5ADY5 Cluster: Putative uncharacterized protein; n=6; ... 36 1.1
UniRef50_Q54WR2 Cluster: Putative uncharacterized protein; n=2; ... 36 1.1
UniRef50_Q973N4 Cluster: Putative uncharacterized protein ST0866... 36 1.1
UniRef50_Q9LTT4 Cluster: WD domain protein-like; n=5; Magnolioph... 35 2.5
UniRef50_A4A615 Cluster: Flagellar hook protein FlgE; n=2; uncla... 34 3.3
UniRef50_A5BJM5 Cluster: Putative uncharacterized protein; n=8; ... 34 3.3
UniRef50_Q0W5L4 Cluster: 3-isopropylmalate dehydrogenase; n=10; ... 34 3.3
UniRef50_P56472 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 34 3.3
UniRef50_A5BSB2 Cluster: Putative uncharacterized protein; n=2; ... 34 4.4
UniRef50_Q5T6L9 Cluster: Transmembrane protein C6orf70; n=39; Am... 33 5.8
UniRef50_Q4GYN8 Cluster: Putative uncharacterized protein; n=1; ... 33 7.7
UniRef50_Q12592 Cluster: 3-isopropylmalate dehydrogenase; n=3; A... 33 7.7
>UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;
Glossina morsitans morsitans|Rep: Isocitrate
dehydrogenase (NAD+) 2 - Glossina morsitans morsitans
(Savannah tsetse fly)
Length = 372
Score = 274 bits (671), Expect = 2e-72
Identities = 132/200 (66%), Positives = 158/200 (79%), Gaps = 1/200 (0%)
Frame = +2
Query: 83 LSRNIFRAVMQGSQ-HVGKGVHTSSVTTEKNQPRATKEGRIKCTLIPGDGVGPELVYAVQ 259
L+R + R +QG Q + +H ++ T P A R CTLIPGDGVGPELV +Q
Sbjct: 2 LARALGRTFIQGLQTSTVRSIHATA--TLNTDPGALGGNRTTCTLIPGDGVGPELVQCLQ 59
Query: 260 EVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAVNKICIKGILATPDFSHTGELQTL 439
EVFK+A +PVDFE +F SEVNP LSA LEDV+ SI NK+CIKG+LATPD+S+ GELQ+L
Sbjct: 60 EVFKSADVPVDFECYFLSEVNPVLSAKLEDVIASIRKNKVCIKGVLATPDYSNVGELQSL 119
Query: 440 NMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQTEGEYSALEHESVPGVVECLKI 619
NMKLRN LDLYANVVH +SLP VK R+QD+D ++IREQTEGEYSALEHESVPG+VECLKI
Sbjct: 120 NMKLRNELDLYANVVHARSLPGVKTRYQDIDIVVIREQTEGEYSALEHESVPGIVECLKI 179
Query: 620 ITAAKSERIAKFAFDYAVED 679
ITA KS RIAKFAFDYA+++
Sbjct: 180 ITAKKSMRIAKFAFDYAIKN 199
>UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit
beta, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=61;
Fungi/Metazoa group|Rep: Isocitrate dehydrogenase [NAD]
subunit beta, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 385
Score = 202 bits (493), Expect = 7e-51
Identities = 103/196 (52%), Positives = 137/196 (69%), Gaps = 4/196 (2%)
Frame = +2
Query: 107 VMQGSQHVGKGVHTSSVTTEKNQPRATK---EGRIKCTLIPGDGVGPELVYAVQEVFKAA 277
V G+ +G+ TS+ ++ +A EG T++PGDGVGPEL++AV+EVFKAA
Sbjct: 15 VSAGNPGAWRGLSTSAAAHAASRSQAEDVRVEGSFPVTMLPGDGVGPELMHAVKEVFKAA 74
Query: 278 SIPVDFESFFFSEV-NPTLSAPLEDVVNSIAVNKICIKGILATPDFSHTGELQTLNMKLR 454
++PV+F+ SEV N LE V++S+ NK+ I G + TP + GEL + +M+LR
Sbjct: 75 AVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAIIGKIHTP-MEYKGELASYDMRLR 133
Query: 455 NALDLYANVVHVKSLPNVKCRHQDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAK 634
LDL+ANVVHVKSLP RH ++D +IIREQTEGEYS+LEHES GV+ECLKI+T AK
Sbjct: 134 RKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAK 193
Query: 635 SERIAKFAFDYAVEDG 682
S+RIAKFAFDYA + G
Sbjct: 194 SQRIAKFAFDYATKKG 209
Score = 33.5 bits (73), Expect = 5.8
Identities = 15/19 (78%), Positives = 16/19 (84%)
Frame = +3
Query: 675 KMGRKKVTAVHKANIMEAG 731
K GR KVTAVHKANIM+ G
Sbjct: 207 KKGRGKVTAVHKANIMKLG 225
>UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=50;
Deuterostomia|Rep: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 393
Score = 163 bits (396), Expect = 4e-39
Identities = 91/185 (49%), Positives = 125/185 (67%), Gaps = 4/185 (2%)
Frame = +2
Query: 140 VHTSSVTTEKNQPRATKEG-RIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSE 316
V + ++ +E+ P + K G R T+IPGDG+GPEL+ V+ VF+ A +PVDFE E
Sbjct: 34 VPSRNIFSEQTIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFE-----E 88
Query: 317 VNPTLSAPLEDVVNSIAV---NKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVH 487
V+ + +A ED+ N+I N++ +KG + T + + ++ N LR +LDLYANV+H
Sbjct: 89 VHVSSNADEEDIRNAIMAIRRNRVALKGNIET-NHNLPPSHKSRNNILRTSLDLYANVIH 147
Query: 488 VKSLPNVKCRHQDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDY 667
KSLP V RH+D+D +I+RE TEGEYS+LEHESV GVVE LKIIT AKS RIA++AF
Sbjct: 148 CKSLPGVVTRHKDIDILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKL 207
Query: 668 AVEDG 682
A E G
Sbjct: 208 AQESG 212
Score = 34.7 bits (76), Expect = 2.5
Identities = 15/17 (88%), Positives = 16/17 (94%)
Frame = +3
Query: 681 GRKKVTAVHKANIMEAG 731
GRKKVTAVHKANIM+ G
Sbjct: 212 GRKKVTAVHKANIMKLG 228
>UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1;
Kluyveromyces lactis|Rep: Isocitrate dehydrogenase [NAD]
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Kluyveromyces lactis (Yeast) (Candida sphaerica)
Length = 361
Score = 159 bits (385), Expect = 9e-38
Identities = 84/162 (51%), Positives = 114/162 (70%)
Frame = +2
Query: 194 GRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAVN 373
GR TLIPGDGVG E+ +V ++F+ +IP+D+E+ S + T + ++ V S+ N
Sbjct: 28 GRYTVTLIPGDGVGKEVTDSVVKIFENENIPIDWETIDISGLENTEN--VQRAVESLKRN 85
Query: 374 KICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQ 553
K+ +KGI TP TG +LN+ LR LD++ANV KS+P VK R ++D +IIRE
Sbjct: 86 KVGLKGIWHTPA-DQTGH-GSLNVALRKQLDIFANVALFKSIPGVKTRLNNIDMVIIREN 143
Query: 554 TEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVED 679
TEGEYS LEHESVPGVVE LKI+T AKSERIA+FAFD+A+++
Sbjct: 144 TEGEYSGLEHESVPGVVESLKIMTRAKSERIARFAFDFALKN 185
>UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 1) (NAD(+)-specific ICDH 1);
n=7; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 1, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 1) (NAD(+)-specific
ICDH 1) - Arabidopsis thaliana (Mouse-ear cress)
Length = 367
Score = 157 bits (382), Expect = 2e-37
Identities = 85/180 (47%), Positives = 118/180 (65%)
Frame = +2
Query: 131 GKGVHTSSVTTEKNQPRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFF 310
G G+ T SVT PR TLIPGDG+GP + AV++V +A P+ FE +
Sbjct: 18 GSGIQTRSVTY---MPRPGDGAPRAVTLIPGDGIGPLVTNAVEQVMEAMHAPIFFEKY-- 72
Query: 311 SEVNPTLSAPLEDVVNSIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHV 490
+V+ +S +V+ SI NK+C+KG L TP G + +LN++LR LDL+A++V+
Sbjct: 73 -DVHGEMSRVPPEVMESIRKNKVCLKGGLKTPV---GGGVSSLNVQLRKELDLFASLVNC 128
Query: 491 KSLPNVKCRHQDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYA 670
+LP + RH++VD ++IRE TEGEY+ LEHE VPGVVE LK+IT SERIAK+AF+YA
Sbjct: 129 FNLPGLPTRHENVDIVVIRENTEGEYAGLEHEVVPGVVESLKVITKFCSERIAKYAFEYA 188
>UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8; n=1; Pan
troglodytes|Rep: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8 - Pan troglodytes
Length = 331
Score = 155 bits (376), Expect = 1e-36
Identities = 82/171 (47%), Positives = 112/171 (65%), Gaps = 4/171 (2%)
Frame = +2
Query: 107 VMQGSQHVGKGVHTSSVTTEKNQPRATK---EGRIKCTLIPGDGVGPELVYAVQEVFKAA 277
V G+ +G+ TS+ ++ +A EG T++PGDGVGPEL++AV+EVFKAA
Sbjct: 15 VSAGNPGAWRGLSTSAAAHAASRSQAEDVRVEGSFPVTMLPGDGVGPELMHAVKEVFKAA 74
Query: 278 SIPVDFESFFFSEV-NPTLSAPLEDVVNSIAVNKICIKGILATPDFSHTGELQTLNMKLR 454
++PV+F+ SEV N LE V++S+ NK+ I G + TP + GEL + +M+LR
Sbjct: 75 AVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAIIGKIHTP-MEYKGELASYDMRLR 133
Query: 455 NALDLYANVVHVKSLPNVKCRHQDVDCIIIREQTEGEYSALEHESVPGVVE 607
LDL+ANVVHVKSLP RH ++D +IIREQTEGEYS+LEHE V E
Sbjct: 134 RKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHECCEEVAE 184
>UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=32;
Dikarya|Rep: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 360
Score = 155 bits (375), Expect = 1e-36
Identities = 84/181 (46%), Positives = 116/181 (64%)
Frame = +2
Query: 128 VGKGVHTSSVTTEKNQPRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFF 307
+ K ++ E+ P+ GR TLIPGDGVG E+ +V+ +F+A +IP+D+E+
Sbjct: 6 IAKRTLATAAQAERTLPKKYG-GRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETIN 64
Query: 308 FSEVNPTLSAPLEDVVNSIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVH 487
+ + + + V S+ NKI +KG+ TP TG +LN+ LR LD+YANV
Sbjct: 65 IKQTDH--KEGVYEAVESLKRNKIGLKGLWHTPA-DQTGH-GSLNVALRKQLDIYANVAL 120
Query: 488 VKSLPNVKCRHQDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDY 667
KSL VK R D+D I+IRE TEGE+S LEHESVPGVVE LK++T K+ERIA+FAFD+
Sbjct: 121 FKSLKGVKTRIPDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDF 180
Query: 668 A 670
A
Sbjct: 181 A 181
>UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 3, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 3) (NAD(+)-specific ICDH 3);
n=23; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 3, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 3) (NAD(+)-specific
ICDH 3) - Arabidopsis thaliana (Mouse-ear cress)
Length = 368
Score = 154 bits (373), Expect = 3e-36
Identities = 78/154 (50%), Positives = 109/154 (70%)
Frame = +2
Query: 209 TLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAVNKICIK 388
TLIPGDG+GP + AV++V +A PV FE + EV + E+V+ S+ NK+C+K
Sbjct: 42 TLIPGDGIGPLVTGAVEQVMEAMHAPVHFERY---EVLGNMRKVPEEVIESVKRNKVCLK 98
Query: 389 GILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQTEGEY 568
G LATP G + +LNM+LR LD++A++V+ ++P + RH++VD ++IRE TEGEY
Sbjct: 99 GGLATPV---GGGVSSLNMQLRKELDIFASLVNCINVPGLVTRHENVDIVVIRENTEGEY 155
Query: 569 SALEHESVPGVVECLKIITAAKSERIAKFAFDYA 670
S LEHE VPGVVE LK+IT SERIA++AF+YA
Sbjct: 156 SGLEHEVVPGVVESLKVITKFCSERIARYAFEYA 189
>UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p -
Drosophila melanogaster (Fruit fly)
Length = 402
Score = 150 bits (364), Expect = 3e-35
Identities = 76/182 (41%), Positives = 115/182 (63%), Gaps = 6/182 (3%)
Frame = +2
Query: 143 HTSSVTTEK----NQPRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFF 310
HT S +K + P A GR T++PG G+GPEL+ V+E+F+ P+DFE
Sbjct: 35 HTKSALQKKVTGTDIPSAQYGGRHAVTMLPGGGIGPELMGYVREIFRYCGAPIDFEVI-- 92
Query: 311 SEVNPTLSA--PLEDVVNSIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVV 484
+++P+ L+ + SI N + +KG + T S T E+ N+ +RN LDLY NVV
Sbjct: 93 -DIDPSTEGNDDLDYAITSIKRNGVALKGNIETKSQSLT-EVSR-NVAIRNELDLYVNVV 149
Query: 485 HVKSLPNVKCRHQDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFD 664
H KS P + RH D+D ++IR+ T+GEY+ LEHESVPG+VE +K++T +ER+A++AF+
Sbjct: 150 HCKSYPGIPARHHDIDVVLIRQNTDGEYAMLEHESVPGIVESMKVVTVENAERVARYAFE 209
Query: 665 YA 670
+A
Sbjct: 210 FA 211
>UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 394
Score = 149 bits (362), Expect = 6e-35
Identities = 76/169 (44%), Positives = 110/169 (65%), Gaps = 4/169 (2%)
Frame = +2
Query: 176 PRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVN----PTLSAPL 343
P A GR TLIPGDG+GPE+V AVQ++F+ +PVDFE S ++ +
Sbjct: 43 PPARYGGRNTVTLIPGDGIGPEMVVAVQDIFRHIGVPVDFEELNLSGLDIKDEDSYLGAF 102
Query: 344 EDVVNSIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQ 523
+ + SI N + +KG + TP + G ++LN++LR LDL+AN+V KS+P ++ RH
Sbjct: 103 NEAITSIKRNGVAMKGNIFTPLDAIPG-FRSLNLELRVHLDLFANIVRCKSIPGIQTRHN 161
Query: 524 DVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYA 670
+VD +IIR+ TEGEYS LEHE+V GV+E LK+ T +IA++AFD+A
Sbjct: 162 NVDLVIIRQNTEGEYSHLEHENVSGVIENLKVTTEEACMKIAQYAFDFA 210
Score = 33.1 bits (72), Expect = 7.7
Identities = 15/19 (78%), Positives = 16/19 (84%)
Frame = +3
Query: 675 KMGRKKVTAVHKANIMEAG 731
K RKKVTAVHKANIM+ G
Sbjct: 212 KHDRKKVTAVHKANIMKMG 230
>UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalytic
subunit 6, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 6) (NAD(+)-specific ICDH 6);
n=10; cellular organisms|Rep: Isocitrate dehydrogenase
[NAD] catalytic subunit 6, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 6) (NAD(+)-specific
ICDH 6) - Arabidopsis thaliana (Mouse-ear cress)
Length = 374
Score = 146 bits (353), Expect = 7e-34
Identities = 90/205 (43%), Positives = 124/205 (60%), Gaps = 3/205 (1%)
Frame = +2
Query: 77 SFLSRNIFRAVMQGSQHV-GKGVHTSSVTTEKNQPRATKEGRIKCTLIPGDGVGPELVYA 253
+FL+R R + GS + G +S ++ + IK TL PGDG+GPE+ +
Sbjct: 5 AFLAR---RLIGNGSSQILGTSSSSSGPFISVSRAFFSSSTPIKATLFPGDGIGPEIAES 61
Query: 254 VQEVFKAASIPVDF-ESFFFSEVNPTLSAPLE-DVVNSIAVNKICIKGILATPDFSHTGE 427
V++VF AA + +D+ E F +EV+P ++ L D + S+ NK+ +KG +ATP G
Sbjct: 62 VKQVFTAADVVIDWDEQFVGTEVDPRTNSFLTWDNLQSVLKNKVGLKGPMATP--IGKGH 119
Query: 428 LQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQTEGEYSALEHESVPGVVE 607
++LN+ LR L+LYANV SLP K R+ DVD I IRE TEGEYS LEH+ V GVVE
Sbjct: 120 -RSLNLTLRKELNLYANVRPCYSLPGYKTRYDDVDLITIRENTEGEYSGLEHQVVKGVVE 178
Query: 608 CLKIITAAKSERIAKFAFDYAVEDG 682
LKIIT S R+A++AF YA G
Sbjct: 179 SLKIITRKASMRVAEYAFLYAKTHG 203
>UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8;
Bilateria|Rep: Isocitrate dehydrogenase - Aedes aegypti
(Yellowfever mosquito)
Length = 393
Score = 144 bits (350), Expect = 2e-33
Identities = 75/167 (44%), Positives = 108/167 (64%), Gaps = 2/167 (1%)
Frame = +2
Query: 176 PRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSA--PLED 349
P+A GR T++PG G+GPEL+ V+EVF+ A +PVDFE +++P LE
Sbjct: 42 PKAHYGGRHTVTMLPGGGIGPELMNYVKEVFRFAGVPVDFEVV---DIDPASEGNDDLEY 98
Query: 350 VVNSIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDV 529
+ SI N + +KG + T + TG + N+ LRN LDLY NV+H KS + HQ+V
Sbjct: 99 AITSIKRNGVALKGNIETKSEA-TGIISR-NVALRNELDLYVNVLHCKSFNAIPAHHQNV 156
Query: 530 DCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYA 670
D +IIR+ TEGEY+ LEHESV GVVE +K++T + R+A++AF++A
Sbjct: 157 DVVIIRQNTEGEYAMLEHESVRGVVESMKVVTVENAARVARYAFEFA 203
>UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3;
Bacteria|Rep: Isocitrate dehydrogenase - Acidobacteria
bacterium (strain Ellin345)
Length = 348
Score = 130 bits (315), Expect = 3e-29
Identities = 73/167 (43%), Positives = 103/167 (61%), Gaps = 2/167 (1%)
Frame = +2
Query: 203 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFF-SEVNPTLSAPLEDVVN-SIAVNK 376
K TLIPGDG+GPE+ A V +A + ++ESF +E + +N SI +
Sbjct: 4 KITLIPGDGIGPEVTSAAVRVLEATGLKFEWESFAAGAEAYEKYKEYIPKELNESIERTR 63
Query: 377 ICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQT 556
I +KG + TP G ++N++LR +LYANV +++LP V R+ VD +++RE T
Sbjct: 64 IGLKGPVTTPI---GGGFSSINVELRKRFELYANVRPIRNLPGVHTRYPGVDLVVVRENT 120
Query: 557 EGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVEDGPQEGH 697
EG YS +EHE VPGVVE LKIIT S RI+KFAF+YA + G ++ H
Sbjct: 121 EGLYSGIEHEVVPGVVESLKIITEKASTRISKFAFNYARKMGRKKIH 167
>UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=31; cellular
organisms|Rep: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 369
Score = 128 bits (310), Expect = 1e-28
Identities = 68/161 (42%), Positives = 103/161 (63%), Gaps = 2/161 (1%)
Frame = +2
Query: 194 GRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSE--VNPTLSAPLEDVVNSIA 367
G+ + I GDG+GPE+ +V+++F AA++P+++ES S VN + P + V SI
Sbjct: 35 GKYTVSFIEGDGIGPEISKSVKKIFSAANVPIEWESCDVSPIFVNGLTTIP-DPAVQSIT 93
Query: 368 VNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIR 547
N + +KG LATP G ++LN+ LR L+ANV KS+ K +++VD ++IR
Sbjct: 94 KNLVALKGPLATP--IGKGH-RSLNLTLRKTFGLFANVRPAKSIEGFKTTYENVDLVLIR 150
Query: 548 EQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYA 670
E TEGEYS +EH PGVV+ +K+IT SER+ ++AF+YA
Sbjct: 151 ENTEGEYSGIEHIVCPGVVQSIKLITRDASERVIRYAFEYA 191
>UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH); n=6;
Eukaryota|Rep: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Caenorhabditis elegans
Length = 358
Score = 124 bits (298), Expect = 3e-27
Identities = 72/188 (38%), Positives = 112/188 (59%), Gaps = 3/188 (1%)
Frame = +2
Query: 128 VGKGVHTSSVTTEKNQPRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFF 307
+GK + +S T ++ ++ + R + TLIPGDG+GPE+ +VQ++F+AA P+ ++
Sbjct: 2 LGKCIKKASSTVGQSIRYSSGDVR-RVTLIPGDGIGPEISASVQKIFEAADAPIAWDPVD 60
Query: 308 FSEV---NPTLSAPLEDVVNSIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYAN 478
+ V + P + + NK+ +KG L TP G ++LN+ +R LYAN
Sbjct: 61 VTPVKGRDGVFRIPSR-CIELMHANKVGLKGPLETP--IGKGH-RSLNLAVRKEFSLYAN 116
Query: 479 VVHVKSLPNVKCRHQDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFA 658
V +SL K + +VD + IRE TEGEYS +EHE VPGVV+ +K+IT S +A FA
Sbjct: 117 VRPCRSLEGHKTLYDNVDVVTIRENTEGEYSGIEHEIVPGVVQSIKLITETASRNVASFA 176
Query: 659 FDYAVEDG 682
F+YA ++G
Sbjct: 177 FEYARQNG 184
>UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=62;
Eukaryota|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Homo sapiens
(Human)
Length = 366
Score = 117 bits (281), Expect = 4e-25
Identities = 66/156 (42%), Positives = 94/156 (60%), Gaps = 2/156 (1%)
Frame = +2
Query: 209 TLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPL--EDVVNSIAVNKIC 382
TLIPGDG+GPE+ AV ++F AA P+ +E + + + + S+ NK+
Sbjct: 35 TLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPSEAKESMDKNKMG 94
Query: 383 IKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQTEG 562
+KG L TP + G ++N+ LR DLYANV S+ K + DV+ + IRE TEG
Sbjct: 95 LKGPLKTPIAA--GH-PSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENTEG 151
Query: 563 EYSALEHESVPGVVECLKIITAAKSERIAKFAFDYA 670
EYS +EH V GVV+ +K+IT S+RIA+FAF+YA
Sbjct: 152 EYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYA 187
>UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9;
Euteleostomi|Rep: NAD+-isocitrate dehydrogenase - Homo
sapiens (Human)
Length = 133
Score = 114 bits (274), Expect = 3e-24
Identities = 57/108 (52%), Positives = 77/108 (71%), Gaps = 1/108 (0%)
Frame = +2
Query: 191 EGRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEV-NPTLSAPLEDVVNSIA 367
EG T++PGDGVGPEL++AV+EVFKAAS+PV+F+ SEV N LE V++S+
Sbjct: 14 EGAFPVTMLPGDGVGPELMHAVKEVFKAASVPVEFQEHHLSEVQNMASEEKLEQVLSSMK 73
Query: 368 VNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVK 511
NK+ I G + TP + GEL + +M+LR LDL+ANV+HVKSLP V+
Sbjct: 74 ENKVAIIGKIHTP-MEYKGELASYDMRLRRKLDLFANVIHVKSLPGVQ 120
>UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=5; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) - Thermus
thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Length = 496
Score = 103 bits (248), Expect = 4e-21
Identities = 63/187 (33%), Positives = 105/187 (56%), Gaps = 6/187 (3%)
Frame = +2
Query: 155 VTTEKNQP-RATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFE--SFFFSEVNP 325
+TTE + ++GR T+IPGDG+GPE V A +V +AA P+ +E S
Sbjct: 4 ITTETGKKMHVLEDGRKLITVIPGDGIGPECVEATLKVLEAAKAPLAYEVREAGASVFRR 63
Query: 326 TLSAPL-EDVVNSIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLP 502
+++ + ++ + SI ++ +KG L TP GE ++ N+ LR + YANV V+ P
Sbjct: 64 GIASGVPQETIESIRKTRVVLKGPLETP--VGYGE-KSANVTLRKLFETYANVRPVREFP 120
Query: 503 NVKCRH--QDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVE 676
NV + + +D +++RE E Y+ +EH P V + LK+I+ SE+I +FAF+ A
Sbjct: 121 NVPTPYAGRGIDLVVVRENVEDLYAGIEHMQTPSVAQTLKLISWKGSEKIVRFAFELARA 180
Query: 677 DGPQEGH 697
+G ++ H
Sbjct: 181 EGRKKVH 187
>UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma;
n=1; Danio rerio|Rep: Isocitrate dehydrogenase 3 (NAD+)
gamma - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 289
Score = 101 bits (242), Expect = 2e-20
Identities = 59/148 (39%), Positives = 92/148 (62%)
Frame = +2
Query: 176 PRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVV 355
P A GR TLIPGDG+GPEL+ V+E+F+ + +PVDFE + + T + + +
Sbjct: 43 PPAKYGGRHTVTLIPGDGIGPELLNHVRELFRFSCVPVDFEVVHVNS-SSTSEDDISNAI 101
Query: 356 NSIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDC 535
+I N + +KG + T + + ++ N LR +LDLYANV+H +SLP V+ RH+++D
Sbjct: 102 MAIRRNGVALKGNIET-NHTMPPNHKSRNNLLRTSLDLYANVMHCQSLPGVQTRHKNIDI 160
Query: 536 IIIREQTEGEYSALEHESVPGVVECLKI 619
III E++ E+SAL E+ VE L++
Sbjct: 161 IIILEKS--EFSALLAENEKIKVELLQL 186
>UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421,
highly similar to PROTEIN KINASE C-BINDING PROTEIN
NELL1; n=2; Homo sapiens|Rep: CDNA FLJ36019 fis, clone
TESTI2016421, highly similar to PROTEIN KINASE C-BINDING
PROTEIN NELL1 - Homo sapiens (Human)
Length = 355
Score = 99.5 bits (237), Expect = 8e-20
Identities = 47/78 (60%), Positives = 60/78 (76%)
Frame = +2
Query: 449 LRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQTEGEYSALEHESVPGVVECLKIITA 628
L LDLYA+V+H+K+LPNV+ H+DVD +++ E TEGEYS LEHESV GV E LKI+T
Sbjct: 2 LHTTLDLYASVIHLKNLPNVETWHKDVDILVVWENTEGEYSNLEHESVKGVTESLKIMTK 61
Query: 629 AKSERIAKFAFDYAVEDG 682
AKS RIA++AF A + G
Sbjct: 62 AKSLRIAEYAFQLAQKMG 79
>UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=6; Rickettsiales|Rep: Isocitrate dehydrogenase,
NADP-dependent - Orientia tsutsugamushi (strain Boryong)
(Rickettsia tsutsugamushi)
Length = 519
Score = 91.5 bits (217), Expect = 2e-17
Identities = 58/164 (35%), Positives = 90/164 (54%), Gaps = 4/164 (2%)
Frame = +2
Query: 200 IKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSE--VNPTLSAPL-EDVVNSIAV 370
I T+ GDG+GPE++ AV V K A++P+ E+ E N + + ED + I
Sbjct: 5 IPVTIAYGDGIGPEIMEAVVYVLKEAAVPLRLETIEIGEKLYNKYYTYGITEDTWSQIFR 64
Query: 371 NKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKS-LPNVKCRHQDVDCIIIR 547
K +KG + TP G ++LN+ LR L LYANV S P V ++D +IIR
Sbjct: 65 TKALLKGPVTTPQ---GGGYKSLNVTLRKTLGLYANVRPSCSYFPFVNTSAPEIDVVIIR 121
Query: 548 EQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVED 679
E E Y+ +E+ E +K+I+ + SE+I +FAF+YA+++
Sbjct: 122 ENEEDLYAGIEYHHTADTYESVKLISRSGSEKIIRFAFEYALKN 165
>UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase family protein; n=9; Bacteria|Rep:
Isopropylmalate/isohomocitrate dehydrogenase family
protein - Synechococcus sp. (strain JA-3-3Ab)
(Cyanobacteria bacteriumYellowstone A-Prime)
Length = 368
Score = 91.1 bits (216), Expect = 3e-17
Identities = 64/182 (35%), Positives = 96/182 (52%), Gaps = 22/182 (12%)
Frame = +2
Query: 203 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFS-EVNPTLSAPLE-DVVNSIAVNK 376
+ TLIPGDG+GPE+ A+ V +A+ + +++ EV PL V+ SI +
Sbjct: 4 RVTLIPGDGIGPEVTRAMTTVLEASGVDLEWIRVEAGVEVIEKYGTPLPPQVLESIRETR 63
Query: 377 ICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQT 556
+ IKG + TP TG +++N+ +R LDLYAN+ KSLP +K QD+D +++RE T
Sbjct: 64 VAIKGPIGTP--VGTG-FRSVNVAIRKELDLYANLRPAKSLPGIKSPFQDIDLVVVRENT 120
Query: 557 EGEYSALEHE-SVP-------------------GVVECLKIITAAKSERIAKFAFDYAVE 676
E Y+ +E E P G +K I+ S RI KFAF+YA +
Sbjct: 121 EDLYAGIEFERGTPEAAHAREEMMRLSGKFIREGSAIGIKPISEFGSRRIVKFAFEYARQ 180
Query: 677 DG 682
+G
Sbjct: 181 NG 182
>UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]
subunit-like 4 (Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4); n=1; Arabidopsis thaliana|Rep:
Putative isocitrate dehydrogenase [NAD] subunit-like 4
(Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4) - Arabidopsis thaliana
(Mouse-ear cress)
Length = 294
Score = 90.6 bits (215), Expect = 4e-17
Identities = 55/141 (39%), Positives = 82/141 (58%), Gaps = 1/141 (0%)
Frame = +2
Query: 251 AVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAVNKICIKGILATPDFSHTGEL 430
AV +V A PV FE++ N ++ +VV+SI NK+C+ G +
Sbjct: 15 AVHQVMDAMQAPVYFETYIIKGKN--MNHLTWEVVDSIRKNKVCLNGRVNN--------- 63
Query: 431 QTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQTEGEYSALEHESVPGVVEC 610
+L R LDL+A++V +L RH++VD ++IRE TEGEY+ EHE VPGV+E
Sbjct: 64 -SLCGGARKELDLFASLVDCFNLNGQPSRHENVDIVVIRENTEGEYAGREHEVVPGVIES 122
Query: 611 LKI-ITAAKSERIAKFAFDYA 670
++ +T S+RIAK+AF+YA
Sbjct: 123 FQVTMTKFWSDRIAKYAFEYA 143
>UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep:
CG3483 protein - Drosophila melanogaster (Fruit fly)
Length = 391
Score = 90.2 bits (214), Expect = 5e-17
Identities = 57/159 (35%), Positives = 88/159 (55%)
Frame = +2
Query: 203 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAVNKIC 382
K TLI G+GVG EL+ AVQEV A P++++ + + E V+ S+ NK+
Sbjct: 71 KVTLINGEGVGRELMDAVQEVICAVKAPIEWDVHDEFKAKDSDDVSPE-VLKSLRANKVG 129
Query: 383 IKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQTEG 562
IKG + D H ++R +A V + + + D D +IIR+Q EG
Sbjct: 130 IKGPV---DSRHW------QRQIRKQFAQFAYVSLCSHIEGLDSPYGDFDVVIIRDQMEG 180
Query: 563 EYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVED 679
+YS +EH VPGV++ +K+ T A + RIA+F F+YAV++
Sbjct: 181 DYSGIEHLVVPGVMQTIKVSTTAGAARIAEFVFNYAVKN 219
>UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68;
Bacteria|Rep: Isocitrate dehydrogenase -
Janthinobacterium sp. (strain Marseille) (Minibacterium
massiliensis)
Length = 349
Score = 89.8 bits (213), Expect = 6e-17
Identities = 61/175 (34%), Positives = 92/175 (52%), Gaps = 7/175 (4%)
Frame = +2
Query: 176 PRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPL--ED 349
P ++ + +I TLIPGDG+GPE+V V VF A P +E+ S L +
Sbjct: 2 PNSSTQQQIPVTLIPGDGIGPEIVDVVVRVFDALGNPFAWETQQAGVNALEKSGDLLPQT 61
Query: 350 VVNSIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDV 529
++SI + +KG L+TP G +++N++LR LYANV +++ R++ +
Sbjct: 62 TLDSIGRTGLALKGPLSTP---IGGGFRSVNVRLRETFQLYANVRPARTIV-PGGRYEKI 117
Query: 530 DCIIIREQTEGEYSALEH-----ESVPGVVECLKIITAAKSERIAKFAFDYAVED 679
D +++RE EG Y EH + V I T A S RI+KFAFDYAV +
Sbjct: 118 DLVLVRENLEGLYVGHEHYVPIGDDAHAVAMATGINTRAGSRRISKFAFDYAVRN 172
>UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2;
Bacteria|Rep: Isocitrate dehydrogenase - Gloeobacter
violaceus
Length = 359
Score = 87.8 bits (208), Expect = 3e-16
Identities = 64/180 (35%), Positives = 96/180 (53%), Gaps = 24/180 (13%)
Frame = +2
Query: 203 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFF---SEVNPTLSAPLE-DVVNSIAV 370
+ TLI GDG+GPE+ A + V A I DFE +EV PL V+ ++
Sbjct: 5 RVTLIRGDGIGPEVTQAARIVLDATGI--DFEWVVVDAGAEVMEKSGTPLPAPVIEAVRA 62
Query: 371 NKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIRE 550
+ IKG + TP S ++++N+ LR ALDLYAN+ ++LP V R+ ++D +++RE
Sbjct: 63 SDAAIKGPITTPAGSG---IRSVNVALRRALDLYANLRPARTLPGVHSRYDNIDLVVVRE 119
Query: 551 QTEGEYSALEHE-SVPGVVE-------------------CLKIITAAKSERIAKFAFDYA 670
TE YS +E E + P +E +K I++ SERIA+FAF+YA
Sbjct: 120 NTEDLYSGIEFEKNSPQALEVIEMLMRLGGKKIFPRSGLAVKPISSEASERIARFAFEYA 179
>UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3;
Rickettsiales|Rep: Isocitrate dehydrogenase - Anaplasma
marginale (strain St. Maries)
Length = 488
Score = 85.8 bits (203), Expect = 1e-15
Identities = 58/161 (36%), Positives = 81/161 (50%), Gaps = 4/161 (2%)
Frame = +2
Query: 200 IKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSE---VNPTLSAPLEDVVNSIAV 370
+ T+ GDGVGPE++ AV + K A V E+ S SI+
Sbjct: 8 VPITVAYGDGVGPEIMEAVLFILKEARADVSIETVDIGHNQYKKEWTSGIAPSAWESISR 67
Query: 371 NKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVH-VKSLPNVKCRHQDVDCIIIR 547
++ +K TP S G ++LN+ LR L LY NV V P V +H D+D +IIR
Sbjct: 68 TRLLLKAPTMTPQGS--GH-KSLNVALRQRLGLYVNVRPCVSYFPVVGTKHPDLDVVIIR 124
Query: 548 EQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYA 670
E E YS +EH+ EC+KI T + SE+I +AF+YA
Sbjct: 125 ENEEDTYSGVEHKLSEDTHECVKISTRSASEKICAYAFNYA 165
>UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanococcus jannaschii
Length = 333
Score = 84.2 bits (199), Expect = 3e-15
Identities = 57/160 (35%), Positives = 83/160 (51%), Gaps = 2/160 (1%)
Frame = +2
Query: 203 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFE-SFFFSEVNPTLSAPLEDVVNSIAVNKI 379
K +I GDG+G E+V A +V +A +P +F + EV L + A++
Sbjct: 3 KICVIEGDGIGKEVVPATIQVLEATGLPFEFVYAEAGDEVYKRTGKALPEETIETALD-- 60
Query: 380 CIKGILATPDFSHTGELQT-LNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQT 556
C +L F GE + +KLR+ LD YAN+ VK+ VKC D+D +I+RE T
Sbjct: 61 C-DAVL----FGAAGETAADVIVKLRHILDTYANIRPVKAYKGVKCLRPDIDYVIVRENT 115
Query: 557 EGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVE 676
EG Y +E E G+ ++IT ERI +FAF+ A E
Sbjct: 116 EGLYKGIEAEIDEGITIATRVITEKACERIFRFAFNLARE 155
>UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanobacterium thermoautotrophicum
Length = 329
Score = 81.4 bits (192), Expect = 2e-14
Identities = 55/165 (33%), Positives = 86/165 (52%), Gaps = 1/165 (0%)
Frame = +2
Query: 200 IKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAVNKI 379
+K +IPGDG+G E++ A + ++ +D E F ++ A L+ ++ +
Sbjct: 4 MKIAVIPGDGIGVEVMEAALHILN--TLDLDLE-FIHADAG---DACLKRTGTALPEETL 57
Query: 380 CIKGILATPDFSHTGELQT-LNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQT 556
G F GE + ++LR DL+AN+ VKSLP V C + D+D +I+RE T
Sbjct: 58 EAVGEARATLFGAAGESAADVIVRLRREFDLFANLRPVKSLPGVPCLYPDLDFVIVRENT 117
Query: 557 EGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVEDGPQE 691
E Y E + G V +IIT S RI++FAF YA ++G Q+
Sbjct: 118 EDLYVGDEEYTPEGAV-AKRIITRTASRRISQFAFQYAQKEGMQK 161
>UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenase
family protein; n=6; Archaea|Rep:
Isocitrate/isopropylmalate dehydrogenase family protein
- Methanosarcina acetivorans
Length = 342
Score = 77.0 bits (181), Expect = 5e-13
Identities = 53/162 (32%), Positives = 81/162 (50%), Gaps = 5/162 (3%)
Frame = +2
Query: 212 LIPGDGVGPELVYAVQEVFKAASIPVDFE-----SFFFSEVNPTLSAPLEDVVNSIAVNK 376
+I GDGVGPELV A+ +V AA V+F + ++ E P ++ + +
Sbjct: 7 VIKGDGVGPELVEAMLKVANAAGTDVEFVMCEAGAGWWEEHGGNSLVP-DETWQILDSSD 65
Query: 377 ICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQT 556
C KG TP G +++ + +R DLYANV +K+ PN DV+ + +RE T
Sbjct: 66 ACFKGPTTTP--GGIGSPRSVAVSIRRKYDLYANVRPIKTFPNSNAPLGDVEMVCVREGT 123
Query: 557 EGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVEDG 682
EG Y E + V ++ IT S +IA++AF+ A G
Sbjct: 124 EGLYIGEEIQLTDDVSIAIRKITRTASGKIARYAFEEAKRRG 165
>UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH).; n=1;
Bos taurus|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH). - Bos Taurus
Length = 260
Score = 75.8 bits (178), Expect = 1e-12
Identities = 35/69 (50%), Positives = 50/69 (72%)
Frame = +2
Query: 464 DLYANVVHVKSLPNVKCRHQDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSER 643
DL ANVV +S P V+ RH+++D +++R+ TEGEYS LE ES+ VVE L+ +T AK R
Sbjct: 17 DLCANVVQFESQPRVETRHKNIDILVVRDNTEGEYSNLEDESMNRVVESLRTVTKAKCLR 76
Query: 644 IAKFAFDYA 670
+A++AF A
Sbjct: 77 LAEYAFQLA 85
>UniRef50_Q4UKR1 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=29; cellular organisms|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Rickettsia felis (Rickettsia azadi)
Length = 483
Score = 73.3 bits (172), Expect = 6e-12
Identities = 48/161 (29%), Positives = 80/161 (49%), Gaps = 4/161 (2%)
Frame = +2
Query: 209 TLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEV---NPTLSAPLEDVVNSIAVNKI 379
T+ GDG+GPE++ AV + + A + E+ E S E+ SI I
Sbjct: 8 TIAYGDGIGPEIMEAVLYILRKAEARIRLETIEVGEKLYKKHYTSGISEESWESIQRTGI 67
Query: 380 CIKGILATPDFSHTGELQTLNMKLRNALDLYANV-VHVKSLPNVKCRHQDVDCIIIREQT 556
+K + TP G ++LN+ +R L L+AN+ V P H ++ IIRE
Sbjct: 68 ILKAPITTPQ---GGGYKSLNVTIRKTLQLFANIRPSVSFHPFTMTLHPHLNLTIIRENE 124
Query: 557 EGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVED 679
E Y+ +E+ + E +K+I+ E+I ++AF+YAV++
Sbjct: 125 EDLYAGIEYRQTHNMYESIKLISHTGCEKIIRYAFEYAVKN 165
>UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Thermoprotei|Rep: 3-isopropylmalate dehydrogenase -
Sulfolobus tokodaii
Length = 337
Score = 72.5 bits (170), Expect = 1e-11
Identities = 48/158 (30%), Positives = 78/158 (49%), Gaps = 4/158 (2%)
Frame = +2
Query: 212 LIPGDGVGPELVYAVQEVF----KAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAVNKI 379
LI GDG+GPE+V + + + S+P+++ E A + + ++ I
Sbjct: 7 LIQGDGIGPEIVSKSKRILAKINELYSLPIEYIEV---EAGDRALARYGEALPKDSLKII 63
Query: 380 CIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQTE 559
I+ + + +KLR D+YAN+ KS+P + ++ +VD +I+RE TE
Sbjct: 64 DKADIILKGPVGESAA--DVVVKLRQIYDMYANIRPAKSIPGIDTKYGNVDILIVRENTE 121
Query: 560 GEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAV 673
Y EH GV +KIIT SERIAK ++A+
Sbjct: 122 DLYKGFEHIVSDGVAVGMKIITRFASERIAKVGLNFAL 159
>UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase; n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Isopropylmalate/isohomocitrate dehydrogenase -
Candidatus Nitrosopumilus maritimus SCM1
Length = 337
Score = 70.5 bits (165), Expect = 4e-11
Identities = 53/162 (32%), Positives = 81/162 (50%), Gaps = 6/162 (3%)
Frame = +2
Query: 203 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFE------SFFFSEVNPTLSAPLEDVVNSI 364
K +LI GDG+GPEL + V + +D + S + T A +D V++I
Sbjct: 3 KISLITGDGIGPELSDSAVSVLETIHDKLDLKFGITKLSAGDKALEQTGKALPDDTVSAI 62
Query: 365 AVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIII 544
+ C+K P ++ + LR LDLYAN+ KS P++ D+D +I+
Sbjct: 63 KQSDACMKA----PVGESAADVIVV---LRRMLDLYANIRPAKSYPHMPALRDDIDMVIV 115
Query: 545 REQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYA 670
RE TE Y+ E S+ L+II+ S+RIAK+AF+ A
Sbjct: 116 RENTEDLYTGKEF-SLGDSSVALRIISEQASKRIAKYAFETA 156
>UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
- Archaeoglobus fulgidus
Length = 326
Score = 70.5 bits (165), Expect = 4e-11
Identities = 46/161 (28%), Positives = 80/161 (49%), Gaps = 1/161 (0%)
Frame = +2
Query: 203 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAVNKIC 382
K +IPGDG+G E++ A + + +P FE ++ + L + + + + C
Sbjct: 3 KIVVIPGDGIGKEVMEAAMLILEKLDLP--FEYSYYDAGDEALEKYGKALPDETL--EAC 58
Query: 383 IKGILATPDFSHTGELQT-LNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQTE 559
K F GE + ++LR L +ANV K++ ++C + +D +++RE TE
Sbjct: 59 RKSDAVL--FGAAGETAADVIVRLRRELGTFANVRPAKAIEGIECLYPGLDIVVVRENTE 116
Query: 560 GEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVEDG 682
Y E V E +++IT SERIA++AF+ A +G
Sbjct: 117 CLYMGFEF-GFGDVTEAIRVITREASERIARYAFELAKREG 156
>UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1;
Planctomyces maris DSM 8797|Rep: Isocitrate
dehydrogenase, putative - Planctomyces maris DSM 8797
Length = 390
Score = 68.5 bits (160), Expect = 2e-10
Identities = 45/133 (33%), Positives = 72/133 (54%), Gaps = 4/133 (3%)
Frame = +2
Query: 203 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFE-SFFFSEVNPTLSAPLEDVVNSIAVNKI 379
K TLIPGDGVGPE+ A ++ A + +D++ EV + V++SI NKI
Sbjct: 3 KVTLIPGDGVGPEIAEATRKCVDATGVKIDWDVQECGIEVIEAEGGVPDRVMDSIRANKI 62
Query: 380 CIKGILATPDFSHTGE-LQTLNMKLRNALDLYANVVHVKSLPNVKCRHQD--VDCIIIRE 550
+K + TP G+ +++N+ LR L LYA + K+ V+ D VD +++RE
Sbjct: 63 ALKAPITTP----IGKGFRSVNVFLRQELGLYACIRPCKTYKGVRTYFADSNVDLVVVRE 118
Query: 551 QTEGEYSALEHES 589
TE Y+ +E ++
Sbjct: 119 NTEDLYAGVEFQA 131
>UniRef50_Q13FQ0 Cluster: Tartrate dehydrogenase; n=3;
Proteobacteria|Rep: Tartrate dehydrogenase -
Burkholderia xenovorans (strain LB400)
Length = 364
Score = 64.9 bits (151), Expect = 2e-09
Identities = 53/171 (30%), Positives = 83/171 (48%), Gaps = 19/171 (11%)
Frame = +2
Query: 215 IPGDGVGPELVYAVQEVFKAA-----SIPVDFESF-----FFSEVNPTLSAPLEDVVNSI 364
IPGDG+G E++ A +V +A S +FE+F ++ E + A D +++I
Sbjct: 9 IPGDGIGKEVIPAGAQVLEALARTSKSFAFEFENFGWGGDYYREHGVMMPA---DGLDAI 65
Query: 365 AVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNV-----KCRHQDV 529
+ G PD L L +K+ D YANV + LP + +C+ D+
Sbjct: 66 RNKDAILFGSAGDPDIPDHITLWGLRLKICQGFDQYANVRPTRILPGIDGPLKRCKPGDL 125
Query: 530 DCIIIREQTEGEYSAL---EHESVP-GVVECLKIITAAKSERIAKFAFDYA 670
+ +I+RE +EGEYS + H+ P + I+T A ERI +FAF A
Sbjct: 126 NWVIVRENSEGEYSGVGGRVHQGHPIEAATDVSILTRAGVERIMRFAFRLA 176
>UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Chloroflexi (class)|Rep: 3-isopropylmalate dehydrogenase
- Roseiflexus sp. RS-1
Length = 362
Score = 63.3 bits (147), Expect = 6e-09
Identities = 54/178 (30%), Positives = 82/178 (46%), Gaps = 10/178 (5%)
Frame = +2
Query: 212 LIPGDGVGPELVYAVQEVFKAASIPVDFESF-----FFSEVNPTLSAPLEDVVNSIAVNK 376
+IPGDG+G E++ A V +A +P FE+ F L P + + A +
Sbjct: 10 VIPGDGIGREVIPAAVAVLRATGLPFHFENADAGWECFQRQGEAL--PSATLTAARAADA 67
Query: 377 ICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHV-KSLP--NVKCRHQDVDCIIIR 547
I + G +A+P + G + ++LR LDLYAN+ V LP R + VD +++R
Sbjct: 68 I-LFGAVASPGYPVAGYRSPI-VRLRRELDLYANIRPVFDDLPENGSNPRRRKVDLVVVR 125
Query: 548 EQTEGEYSALEHESVPGVVECL-KIITAAKSERIAKFAFDYA-VEDGPQEGHRCPQGQ 715
E TE Y+ E G ++IT S RI + A D A + G P G+
Sbjct: 126 ENTEDVYAGRERVEDDGATAIAERVITRRASARIMRVACDLARARRSARNGSDAPPGR 183
>UniRef50_O29610 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=15; Archaea|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Archaeoglobus fulgidus
Length = 412
Score = 62.1 bits (144), Expect = 1e-08
Identities = 48/149 (32%), Positives = 76/149 (51%), Gaps = 9/149 (6%)
Frame = +2
Query: 221 GDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPL------EDVVNSIAVNKIC 382
GDG+G ++V A V AA+ + E +F + L +D +N+I ++
Sbjct: 35 GDGIGKDVVPAAIRVLDAAADKIGKEVVWFQVYAGEDAYKLYGNYLPDDTLNAIKEFRVA 94
Query: 383 IKGILATPDFSHTGELQTLNMKLRNALDLYAN---VVHVKSLPNVKCRHQDVDCIIIREQ 553
+KG L TP G ++LN+ +R LDLYAN V ++K +P+ + V+ +I RE
Sbjct: 95 LKGPLTTPV---GGGYRSLNVTIRQVLDLYANVRPVYYLKGVPSPIKHPEKVNFVIFREN 151
Query: 554 TEGEYSALEHESVPGVVECLKIITAAKSE 640
TE Y+ +E G E LK+I K+E
Sbjct: 152 TEDVYAGIEWPR--GSEEALKLIRFLKNE 178
>UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;
n=4; Thermococcaceae|Rep: LeuB-2 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 346
Score = 61.3 bits (142), Expect = 3e-08
Identities = 53/160 (33%), Positives = 79/160 (49%), Gaps = 2/160 (1%)
Frame = +2
Query: 203 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFS-EVNPTLSAPL-EDVVNSIAVNK 376
+ +I GDG+GPE+V + V + + + F F EV + +P+ ED + I
Sbjct: 3 RVAVIKGDGIGPEVVDSAIRVVNSVTDRIRFYEFEGGFEVFKRIGSPISEDDLKEIRKMD 62
Query: 377 ICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQT 556
+ G TP F+ G ++L + LR LDLYAN+ + L N K + +I+RE T
Sbjct: 63 AILFGATTTP-FNVPG-YRSLIVTLRKELDLYANLRIIPDLSNGK------EIVIVRENT 114
Query: 557 EGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVE 676
EG Y A + +IIT + RIAKFA + A E
Sbjct: 115 EGLY-ARDGIGFSDRAIDFRIITLEGARRIAKFAINLAKE 153
>UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Methanosaeta thermophila PT|Rep: Isocitrate
dehydrogenase (NAD(+)) - Methanosaeta thermophila
(strain DSM 6194 / PT) (Methanothrixthermophila (strain
DSM 6194 / PT))
Length = 375
Score = 60.9 bits (141), Expect = 3e-08
Identities = 50/164 (30%), Positives = 79/164 (48%), Gaps = 12/164 (7%)
Frame = +2
Query: 215 IPGDGVGP----ELVYAVQEVFK--AASIPVDF---ESFFFSEVNPTLSAPLEDVVNSIA 367
+ GDG+GP E + +Q + + V+F E E + A +D ++++
Sbjct: 21 VDGDGIGPYITGEAIRVLQSLLRDELERGDVEFRKIEGLSIEERARAMKALPDDALDALK 80
Query: 368 VNKICIKGILATPDFSHTG-ELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIII 544
+ +KG L TP L++ N+ +R LDL+ANV V S+P+ + +D +
Sbjct: 81 KCHVILKGPLTTPKKGDPWPNLESANVAMRRELDLFANVRPV-SIPS-----EGIDWVFF 134
Query: 545 REQTEGEY--SALEHESVPGVVECLKIITAAKSERIAKFAFDYA 670
RE TEGEY + + K+IT SERI + AFDYA
Sbjct: 135 RENTEGEYVLGSKGFNVTDDLAVDFKVITTQGSERIIRLAFDYA 178
>UniRef50_Q2UP37 Cluster: Isocitrate/isopropylmalate dehydrogenase;
n=1; Aspergillus oryzae|Rep: Isocitrate/isopropylmalate
dehydrogenase - Aspergillus oryzae
Length = 350
Score = 60.5 bits (140), Expect = 4e-08
Identities = 46/170 (27%), Positives = 80/170 (47%), Gaps = 13/170 (7%)
Frame = +2
Query: 212 LIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTL--SAPLEDVVNSIAVNKICI 385
++ G+G+GPE+ A V +A I +++ ++ L A V+ I K CI
Sbjct: 5 VLKGNGIGPEITAATIRVIEATGIQPEWDFIPIADEAVRLYGHALPPQVIQRIKDVKFCI 64
Query: 386 KG-ILATPDFSHTGELQT---------LNMKLRNALDLYANVVHVKSLPNVKCRHQDVDC 535
K +LA QT +N +R L+L+ N ++ + RH+ +D
Sbjct: 65 KAPLLAEKLHGRISCTQTDGSVVTYPSINNAIRRELNLFVNPRPIRGYVGISGRHEKMDM 124
Query: 536 IIIREQTEGEYSALEHESVPGVV-ECLKIITAAKSERIAKFAFDYAVEDG 682
+I+RE TE Y E G E +K +T + S +++++AF+YA + G
Sbjct: 125 VIMREITEDTYIGWEKPLEDGAAAEAIKRVTRSASWKVSQYAFEYARKHG 174
>UniRef50_Q9RTT2 Cluster: Isocitrate dehydrogenase, putative; n=2;
Deinococcus|Rep: Isocitrate dehydrogenase, putative -
Deinococcus radiodurans
Length = 333
Score = 60.1 bits (139), Expect = 6e-08
Identities = 46/163 (28%), Positives = 77/163 (47%), Gaps = 3/163 (1%)
Frame = +2
Query: 197 RIKCTLIPGDGVGPELVYAVQEVFKAASIPVDF---ESFFFSEVNPTLSAPLEDVVNSIA 367
+ + LI GDG+G E++ A + V +AA ++ E+ + ++ S P E +++
Sbjct: 3 KYRICLIEGDGIGHEVIPAAKRVLEAAGFDAEYVHAEAGYEYFLDHGTSVP-EATYDAVE 61
Query: 368 VNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIR 547
+ G +P LR +LYANV K+ P V +++VD +I+R
Sbjct: 62 NTDATLFGAATSPSGEKPAGFFGAIRHLRQKYNLYANVRPTKTRP-VPHSYENVDLVIVR 120
Query: 548 EQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVE 676
E T+G Y E + +IT S+RI KFA D A++
Sbjct: 121 ENTQGLYVEQERRYGDTAI-ADTVITREASDRIGKFAADLAMK 162
>UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Saccharopolyspora erythraea NRRL 2338|Rep:
3-isopropylmalate dehydrogenase - Saccharopolyspora
erythraea (strain NRRL 23338)
Length = 407
Score = 58.8 bits (136), Expect = 1e-07
Identities = 58/178 (32%), Positives = 79/178 (44%), Gaps = 15/178 (8%)
Frame = +2
Query: 212 LIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSE-VNPTLSAPLEDVVNSIAVNKI--- 379
+IPGDG+GPELV + EV +AA+ D E F SE +++ + +I
Sbjct: 11 VIPGDGIGPELVRSAVEVLRAAA-GRDVELRFTSEDAGADAFRRTGSAMSAATLERIRTR 69
Query: 380 ---CIKGILATPDFSHTG--ELQTLNMKLRNALDLYANVVHVKSLPNVKC--RHQDVDCI 538
+KG + P H E L LR LD YANV + LP V R VD +
Sbjct: 70 YHGVLKGPVGLPGVRHPDGTEAGLLGGVLRGGLDTYANVRPIALLPGVDAPLRGTAVDYV 129
Query: 539 IIREQTEGEYSALEHESVPGVVECLK--IITAAKSERIAKFAFDYAVE--DGPQEGHR 700
I+RE TEG Y + V C ++T ER+ AF+ A P +G R
Sbjct: 130 IVRENTEGLYLS-RGRGVGNDRACADQLLMTRHGVERVVVHAFELATRRTGAPADGVR 186
>UniRef50_Q2Q9C5 Cluster: Isocitrate dehydrogenase 3 gamma; n=8;
Eutheria|Rep: Isocitrate dehydrogenase 3 gamma - Homo
sapiens (Human)
Length = 88
Score = 58.4 bits (135), Expect = 2e-07
Identities = 34/87 (39%), Positives = 54/87 (62%), Gaps = 4/87 (4%)
Frame = +2
Query: 140 VHTSSVTTEKNQPRATKEG-RIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSE 316
V + ++ +E+ P + K G R T+IPGDG+GPEL+ V+ VF+ A +PVDFE E
Sbjct: 7 VPSRNIFSEQTIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFE-----E 61
Query: 317 VNPTLSAPLEDVVNSIAV---NKICIK 388
V+ + +A ED+ N+I N++ +K
Sbjct: 62 VHVSSNADEEDICNAIMAIRRNRVALK 88
>UniRef50_Q4V533 Cluster: IP13250p; n=4; Drosophila
melanogaster|Rep: IP13250p - Drosophila melanogaster
(Fruit fly)
Length = 475
Score = 58.0 bits (134), Expect = 2e-07
Identities = 29/90 (32%), Positives = 47/90 (52%)
Frame = +2
Query: 443 MKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQTEGEYSALEHESVPGVVECLKII 622
+K+ N LDLY +S P KCR VD +I + G ++ LE+ V GVVE L ++
Sbjct: 132 LKICNDLDLYVFKTRTRSFPGFKCRFPGVDIQLIGQNNMGIFNELEYSPVEGVVEALSVV 191
Query: 623 TAAKSERIAKFAFDYAVEDGPQEGHRCPQG 712
+ +++ ++AF A + G + QG
Sbjct: 192 SQKGNDKYLRYAFKAAAKAGRKRVTLIKQG 221
>UniRef50_A6PN62 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Victivallis vadensis ATCC BAA-548|Rep: 3-isopropylmalate
dehydrogenase - Victivallis vadensis ATCC BAA-548
Length = 369
Score = 57.6 bits (133), Expect = 3e-07
Identities = 48/171 (28%), Positives = 78/171 (45%), Gaps = 15/171 (8%)
Frame = +2
Query: 203 KCTLIPGDGVGPELVYAVQEVFKAASIPVDF--ESFFFSEVNPTLSAPLE----DVVNSI 364
K ++PGDG GPE++ +V AA F E +++ A E D +
Sbjct: 6 KIAVLPGDGTGPEVIAEAVKVLDAAGRKFGFTTEKEYYNWGGAHYLATGETLPADAKEQL 65
Query: 365 AVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKC-----RHQDV 529
A + + G + PD + + +KLR LD Y N+ VK P V+ + +D+
Sbjct: 66 ARHDAVLLGAIGHPDVKPGVLEKGILLKLRFDLDQYINLRPVKLFPGVETPLANKKPEDI 125
Query: 530 DCIIIREQTEGEYSALEHE---SVPGVVECLK-IITAAKSERIAKFAFDYA 670
D +++RE + G Y+ + P V C I T ++ +R KFAF+ A
Sbjct: 126 DYVVVRENSGGVYTGMGGNVQIDTPEEVACQNWIYTRSQVDRCLKFAFELA 176
>UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=2; Archaea|Rep: Isocitrate dehydrogenase,
NADP-dependent - Halorubrum lacusprofundi ATCC 49239
Length = 463
Score = 56.0 bits (129), Expect = 9e-07
Identities = 47/142 (33%), Positives = 72/142 (50%), Gaps = 10/142 (7%)
Frame = +2
Query: 212 LIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAP-------LEDVVNSIAV 370
+I GDG+G ++ A Q+V AA+ S + V SA ED V++I
Sbjct: 78 IIHGDGIGTDVGPAAQKVLDAAAEATG-RSIAWMRVYAGGSARDMYDENLPEDTVSAIRD 136
Query: 371 NKICIKGILATPDFSHTGELQTLNMKLRNALDLYANV---VHVKSLPNVKCRHQDVDCII 541
+++ IKG L TP + ++LN+ LR LDLYANV ++ +P+ + +D I
Sbjct: 137 HRVAIKGPLTTPVGAG---FRSLNVALRKTLDLYANVRPTYYLDGVPSPVKNPEKMDMIT 193
Query: 542 IREQTEGEYSALEHESVPGVVE 607
RE TE Y+ +E E+ VE
Sbjct: 194 FRENTEDVYAGIEWEAGTDEVE 215
>UniRef50_Q44471 Cluster: Probable tartrate
dehydrogenase/decarboxylase ttuC; n=66; cellular
organisms|Rep: Probable tartrate
dehydrogenase/decarboxylase ttuC - Agrobacterium vitis
(Rhizobium vitis)
Length = 364
Score = 54.8 bits (126), Expect = 2e-06
Identities = 50/175 (28%), Positives = 75/175 (42%), Gaps = 19/175 (10%)
Frame = +2
Query: 203 KCTLIPGDGVGPELVYAVQEV----------FKAASIPVDFESFFFSEVNPTLSAPLEDV 352
K IP DG+GPE++ A +V FK + D+ S ++ + + A D
Sbjct: 5 KIAAIPADGIGPEVIAAGLQVLEALEQRSGDFKIHTETFDWGSDYYKKHGVMMPA---DG 61
Query: 353 VNSIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNV-----KCR 517
++ + G + PD L L + + D YANV K LP + C
Sbjct: 62 LDKLKKFDAIFFGAVGAPDVPDHITLWGLRLPICQGFDQYANVRPTKILPGITPPLRNCG 121
Query: 518 HQDVDCIIIREQTEGEYS---ALEHESVPGVVEC-LKIITAAKSERIAKFAFDYA 670
D+D +I+RE +EGEYS H +P V + I T RI ++AF A
Sbjct: 122 PGDLDWVIVRENSEGEYSGHGGRAHRGLPEEVGTEVAIFTRVGVTRIMRYAFKLA 176
>UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;
n=1; Ignicoccus hospitalis KIN4/I|Rep: 3-isopropylmalate
dehydrogenase - Ignicoccus hospitalis KIN4/I
Length = 343
Score = 54.4 bits (125), Expect = 3e-06
Identities = 43/163 (26%), Positives = 73/163 (44%), Gaps = 6/163 (3%)
Frame = +2
Query: 200 IKCTLIPGDGVGPELVYAVQEVFKAASIPVDFE-SFFFSEVNPTLSAPLEDVVNSIAVNK 376
+ +I GDG+GPE+V A +V + F F E + + + +
Sbjct: 2 VTVAVIEGDGIGPEVVGATLKVLEKIRETFKLPLEFVFVEAGDRAKEKYGEALPKESYER 61
Query: 377 ICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQT 556
+ + T + ++LR LDL+AN+ K LP V ++VD II+RE
Sbjct: 62 LLRADAILKGPVGETAA--DVIVRLRRELDLFANIRPAKVLPGVPALKENVDLIIVRENI 119
Query: 557 EGEYSALEH---ESVPG--VVECLKIITAAKSERIAKFAFDYA 670
E Y E+ ++ G V L++ + ++ R+AK A +YA
Sbjct: 120 EDLYVGAENLLPQTSLGHKVAVGLRLASERETRRVAKVAAEYA 162
>UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Proteobacteria|Rep: 3-isopropylmalate dehydrogenase -
Bradyrhizobium japonicum
Length = 365
Score = 54.4 bits (125), Expect = 3e-06
Identities = 50/170 (29%), Positives = 78/170 (45%), Gaps = 15/170 (8%)
Frame = +2
Query: 212 LIPGDGVGPELVYAVQEVFKAAS------IPVDFESFFFSEVNPTLSAPLEDVVNSIAVN 373
++PGDG+GPE+ A V +AAS + ++ + + + + ++++ +
Sbjct: 17 VLPGDGIGPEITTATSGVLRAASERFQLNLRLEEHAVGHASLKQFGTTVRPELLDIVRGA 76
Query: 374 KICIKGILATPDFSHT--GELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIR 547
I G AT DF GE+ + R LDLYANV ++ R D D +++R
Sbjct: 77 DGLILGPTATFDFKDEAHGEINP-SRHFRKNLDLYANVRPARTYAGRPGRLGDFDLVVVR 135
Query: 548 EQTEGEYSALEHES-------VPGVVECLKIITAAKSERIAKFAFDYAVE 676
E TEG Y+ E P V L+ IT A ERIA A A++
Sbjct: 136 ENTEGFYADRNMEQGNGEMLVTPDVAISLRRITRACCERIAHAACRLAMK 185
>UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep: Isocitrate
dehydrogenase (NAD(+)) - Candidatus Nitrosopumilus
maritimus SCM1
Length = 343
Score = 54.4 bits (125), Expect = 3e-06
Identities = 44/162 (27%), Positives = 74/162 (45%), Gaps = 6/162 (3%)
Frame = +2
Query: 203 KCTLIPGDGVGPELVYAVQEVFKAAS-----IPVDFESFFFSEVNPTLSAPLEDVVNSIA 367
K ++ GDG+GPE+V ++ V K + I + S + + ++ + DV I
Sbjct: 4 KAAVMKGDGIGPEVVDSMLRVLKECNFQSELILCEAGSEQWDKNGRKDASYIPDVTMKIL 63
Query: 368 VNK-ICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIII 544
C KG T G +++ + LR DLYAN+ K+ + + +DC+
Sbjct: 64 EETDCCFKG--PTTTIPVPGAPRSVAVTLRQKFDLYANIRPTKTYDRLT-PDRKLDCVCF 120
Query: 545 REQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYA 670
RE TEG Y+ +E + ++ IT S R+ A D+A
Sbjct: 121 REATEGLYTGVEAKITDDAAIAIRKITRQGSRRLIDSAVDWA 162
>UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase;
n=106; Bacteria|Rep: Tartrate
dehydrogenase/decarboxylase - Pseudomonas putida
Length = 365
Score = 53.6 bits (123), Expect = 5e-06
Identities = 49/170 (28%), Positives = 79/170 (46%), Gaps = 18/170 (10%)
Frame = +2
Query: 215 IPGDGVGPELVYAVQEVFKAASIP----VDFESFFFSEVNPTLSAPL---EDVVNSIAVN 373
IPGDG+G E++ V +AA++ ++F++F ++ + L +D +
Sbjct: 11 IPGDGIGLEVLPEGIRVLEAAALKHGLALEFDTFEWASCDYYLQHGKMMPDDWAEQLKQY 70
Query: 374 KICIKGILATPDF--SHTGELQTLNMKLRNALDLYANVVHVKSLPNVKC-----RHQDVD 532
G + PD H +L +K R D Y N+ V+ P V C + D+D
Sbjct: 71 DAIYFGAVDWPDKVPDHISLWGSL-LKFRREFDQYVNIRPVRLFPGVPCALANRKVGDID 129
Query: 533 CIIIREQTEGEYSALE----HESVPGVVECLKIITAAKSERIAKFAFDYA 670
+++RE TEGEYS+L + +V I T +RI K+AFD A
Sbjct: 130 FVVVRENTEGEYSSLGGIMFENTENEIVIQESIFTRRGVDRILKYAFDLA 179
>UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1;
Entamoeba histolytica HM-1:IMSS|Rep: tartrate
dehydrogenase - Entamoeba histolytica HM-1:IMSS
Length = 370
Score = 53.2 bits (122), Expect = 7e-06
Identities = 40/163 (24%), Positives = 78/163 (47%), Gaps = 9/163 (5%)
Frame = +2
Query: 203 KCTLIPGDGVGPELVYAVQEVFKAASIPV--DFESFFFSEVNPTLSAPLEDVVNSIAVNK 376
K +IPGDG+G E++ +++F++ ++P+ D+ + T D ++ +
Sbjct: 12 KIIVIPGDGIGAEVMNEAEKMFQSLNLPIQRDYVDWGIQHYLKTGKVVPIDYIDQVKQYD 71
Query: 377 ICIKGILATP-DFSHTGELQTLNMKLRNALDLYANVVHVKSLPNV--KCRHQDVDCIIIR 547
+ G L P L+ L +++R LD + + K P + + ++D +++R
Sbjct: 72 AILLGSLGDPRTLPDYVTLEPL-IQMRQQLDQFLCLRPAKHFPGIPTPLKKCEIDVLVVR 130
Query: 548 EQTEGEYSALEHESVPGVVECLKIITAAKS----ERIAKFAFD 664
E +EGEYS + G E I +A S ER+ ++AF+
Sbjct: 131 ENSEGEYSNIGGIFKSGTPEEFAIESAVHSRRGLERVIRYAFE 173
>UniRef50_Q8XSY8 Cluster: Probable 3-isopropylmalate dehydrogenase
oxidoreductase protein; n=1; Ralstonia solanacearum|Rep:
Probable 3-isopropylmalate dehydrogenase oxidoreductase
protein - Ralstonia solanacearum (Pseudomonas
solanacearum)
Length = 365
Score = 52.0 bits (119), Expect = 2e-05
Identities = 47/176 (26%), Positives = 84/176 (47%), Gaps = 17/176 (9%)
Frame = +2
Query: 200 IKCTLIPGDGVGPELVYAVQEVFKAA------SIPVDFESFFFSEVNPTLSAPLEDVVNS 361
++ ++P DG+GPE+V A EV ++A + D++ F+ + + ++V+
Sbjct: 1 MRILVLPCDGIGPEIVGAAMEVLRSADSVFKLDLAFDYDDVGFTSLEKYGTTLRDEVLAK 60
Query: 362 IAVNKICIKGILATPDFSHTGE-LQTLNMKLRNALDLYANVVHVKSLPNVKCRHQD---V 529
I G + D+ + + ++ R LDLYANV ++ P + ++ +
Sbjct: 61 AKTYDGVILGTQSHADYPAPDKGGRNVSAGFRIGLDLYANVRPARTRPFLTSNMREGRTM 120
Query: 530 DCIIIREQTEGEY-------SALEHESVPGVVECLKIITAAKSERIAKFAFDYAVE 676
D +I+RE TEG Y E P + L+ IT SERIA+ AF+ A++
Sbjct: 121 DLVIMREATEGFYPDRNMTKGWAELMPSPDMAISLRKITRHCSERIARRAFELAMK 176
>UniRef50_Q0X0C1 Cluster: Putative dehydrogenase; n=1; Streptomyces
lasaliensis|Rep: Putative dehydrogenase - Streptomyces
lasaliensis
Length = 362
Score = 52.0 bits (119), Expect = 2e-05
Identities = 43/165 (26%), Positives = 72/165 (43%), Gaps = 12/165 (7%)
Frame = +2
Query: 212 LIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTL---SAPLEDVVNSIAVNKIC 382
+IPGDG+GPE++ +V A + + + L A ++ I ++
Sbjct: 24 VIPGDGIGPEVIEPALDVLDALGLGTRTDILDHVNADTYLRTGEALTGSDLDRIRSSEAA 83
Query: 383 IKGILATPDFSHTGELQTLNMKLRNALDLYAN-----VVHVKSLPNVKCRHQDVDCIIIR 547
+ G + P T ++ + LR LDLY N + H + P + +DC+I+R
Sbjct: 84 LLGAVGDPRLGDTSYVRGVLTTLRLELDLYVNYRPARLWHDRLSPLRDPARRAIDCVIVR 143
Query: 548 EQTEGEYSALEHESVPGVVECLKI----ITAAKSERIAKFAFDYA 670
E TEG YS + + G E + + T R+ +FAF A
Sbjct: 144 ENTEGLYSGIGGGARTGTPEEIAVDVDLSTRHGVSRVLEFAFSAA 188
>UniRef50_Q0W1Q6 Cluster: 2-isopropylmalate dehydrogenase; n=5;
Euryarchaeota|Rep: 2-isopropylmalate dehydrogenase -
Uncultured methanogenic archaeon RC-I
Length = 324
Score = 52.0 bits (119), Expect = 2e-05
Identities = 46/156 (29%), Positives = 72/156 (46%), Gaps = 3/156 (1%)
Frame = +2
Query: 200 IKCTLIPGDGVGPELVYAVQEVFKAASIPVDF---ESFFFSEVNPTLSAPLEDVVNSIAV 370
+K ++PGDG+G E+V EV K A +F E V +S D+ A
Sbjct: 1 MKIAVLPGDGIGREVVPVAHEVLKVALPDAEFLHVEVGNERYVREGVSMSPADLETVKAC 60
Query: 371 NKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIRE 550
+ + I + P + +++ + LR LDLYAN+ +S P + V+ I RE
Sbjct: 61 DCVLFGAITSPPGKPY----RSIILTLRKELDLYANIRPFRSCP---ISPRKVNFTIYRE 113
Query: 551 QTEGEYSALEHESVPGVVECLKIITAAKSERIAKFA 658
+E Y +E E +++IT SERIA+ A
Sbjct: 114 NSEDLYMGIE-EITGDEARSVRVITRKASERIARAA 148
>UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Thermoproteaceae|Rep: 3-isopropylmalate dehydrogenase -
Pyrobaculum aerophilum
Length = 290
Score = 50.8 bits (116), Expect = 4e-05
Identities = 28/74 (37%), Positives = 42/74 (56%)
Frame = +2
Query: 449 LRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQTEGEYSALEHESVPGVVECLKIITA 628
+R LYAN+ VK+LP V +++DC+ +RE E Y E++ V V LK+IT
Sbjct: 50 IRMRYTLYANIRPVKNLPGVPAV-REIDCVFVRENVEDVYVGAEYK-VGDVAIALKVITE 107
Query: 629 AKSERIAKFAFDYA 670
+ R+A+ A YA
Sbjct: 108 KGTRRVARMARKYA 121
>UniRef50_Q8U299 Cluster: 3-isopropylmalate dehydrogenase 2; n=3;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
2 - Pyrococcus furiosus
Length = 355
Score = 50.8 bits (116), Expect = 4e-05
Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 18/179 (10%)
Frame = +2
Query: 200 IKCTLIPGDGVGPELV----YAVQEVFKAASIPVDFESFFFS-----EVNPTL-SAPLED 349
IK +IPGDG+G E+V ++++ + +++ DF+ + F + TL LE+
Sbjct: 2 IKIAVIPGDGIGKEVVAEGLKVLRKIEELSNVKFDFQEYPFGAEHYLKTGETLPDWALEE 61
Query: 350 VVNSIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVK----SLPNVKCR 517
+ A+ I P G L +KLR +LDLY N+ VK L +K +
Sbjct: 62 FRHFDAIYFGAIGDPRVKPGILEHGIL----LKLRFSLDLYVNLRPVKLYHPKLTPLKGK 117
Query: 518 HQDVDCIIIREQTEGEYS---ALEHESVPGVVECLKII-TAAKSERIAKFAFDYAVEDG 682
+ +D + IRE TEG Y+ + P V ++I T ER +FAF+YA G
Sbjct: 118 -EKIDMVFIRENTEGLYAGAGGFLRKGTPHEVAIQEMINTRFGVERTIRFAFEYAKTKG 175
>UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=504; root|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Helicobacter pylori (Campylobacter pylori)
Length = 425
Score = 49.6 bits (113), Expect = 8e-05
Identities = 39/122 (31%), Positives = 62/122 (50%), Gaps = 4/122 (3%)
Frame = +2
Query: 308 FSEVNPTLSAPLEDVVNSIAVNKICIKGILATPDFSHTGE-LQTLNMKLRNALDLYANVV 484
+ E++P L D + +I K+ IKG L TP GE ++LN+ LR +DLY +
Sbjct: 84 YKELSPEEQWLLPDTIEAINHYKVSIKGPLTTP----IGEGFRSLNVALRQKMDLYVCLR 139
Query: 485 HVK--SLPNVKCRHQDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSE-RIAKF 655
V+ P+ Q VD +I RE +E Y+ +E + G E K+I ++E ++ K
Sbjct: 140 PVRWYGSPSPVKEPQKVDMVIFRENSEDIYAGIEWQE--GSAEAKKLIHFLQNELKVKKI 197
Query: 656 AF 661
F
Sbjct: 198 RF 199
>UniRef50_P41566 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 106
Score = 41.5 bits (93), Expect(2) = 1e-04
Identities = 25/63 (39%), Positives = 34/63 (53%)
Frame = +2
Query: 176 PRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVV 355
P A G + T+ PGDG GPEL+ V +A +PVDFE EV + +A ED+
Sbjct: 8 PSAKYGGILTVTMSPGDGDGPELMLTVXXXXXSACVPVDFE-----EVVVSSNADEEDIR 62
Query: 356 NSI 364
S+
Sbjct: 63 TSL 65
Score = 27.5 bits (58), Expect(2) = 1e-04
Identities = 10/15 (66%), Positives = 13/15 (86%)
Frame = +2
Query: 449 LRNALDLYANVVHVK 493
+R +LDLYANV+H K
Sbjct: 61 IRTSLDLYANVIHCK 75
>UniRef50_Q67LW7 Cluster: Tartrate dehydrogenase; n=2; Bacteria|Rep:
Tartrate dehydrogenase - Symbiobacterium thermophilum
Length = 359
Score = 48.8 bits (111), Expect = 1e-04
Identities = 50/174 (28%), Positives = 81/174 (46%), Gaps = 17/174 (9%)
Frame = +2
Query: 200 IKCTLIPGDGVGPELVYAVQEVFKAAS-----IPVDFESFFFS---EVNPTLSAPLEDVV 355
+ +IPGDG+G E V A + V AA+ I ++ F + + AP + +
Sbjct: 4 VSVAVIPGDGIGNETVRAGRRVLDAAAELDGGIKFEYTEFEWGCAYYLRHGEMAP-KGFL 62
Query: 356 NSIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNV----KCRHQ 523
N++A + G + P L L + +R + Y N+ V+ L V + R+
Sbjct: 63 NTLANFDTILLGAVGYPGVPDHVSLWGLLLPIRRGFEQYVNLRPVRILRGVVSPLRGRNP 122
Query: 524 -DVDCIIIREQTEGEYSALE---HESVP-GVVECLKIITAAKSERIAKFAFDYA 670
DV+ + IRE TEGEYS + H +P VV + T +ERI ++A+ A
Sbjct: 123 GDVNFVCIRENTEGEYSNMGGRLHAGLPHEVVVQNTVFTRVGTERIIRYAYQLA 176
>UniRef50_A7GLU7 Cluster: Tartrate dehydrogenase; n=3; Bacteria|Rep:
Tartrate dehydrogenase - Bacillus cereus subsp.
cytotoxis NVH 391-98
Length = 364
Score = 48.8 bits (111), Expect = 1e-04
Identities = 44/173 (25%), Positives = 73/173 (42%), Gaps = 16/173 (9%)
Frame = +2
Query: 200 IKCTLIPGDGVGPELV---YAVQEVFKAASIPVDFESFFFS---EVNPTLSAPLEDV-VN 358
+K +I GDG+GPE++ V + S FE +F E ++D +
Sbjct: 4 LKVAVIAGDGIGPEVMDEGVKVLQTIANVSQQFKFEFTYFPWGCEFYSKHGKMMDDDGIE 63
Query: 359 SIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKC-----RHQ 523
+ G + P L L +++R + D Y N+ V L C + +
Sbjct: 64 QLKAFDAIYLGAVGFPGVPDYISLWDLLLRIRQSFDQYVNIRPVTLLKGAPCPLKDVKRE 123
Query: 524 DVDCIIIREQTEGEYSALEHESVPG----VVECLKIITAAKSERIAKFAFDYA 670
D+D + IRE +EGEY+ G VV + + +ERI ++AF+ A
Sbjct: 124 DIDMLFIRENSEGEYAGAGDWLYKGKEHEVVLQNSVFSRKGTERIIRYAFEIA 176
>UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodococcus sp. (strain RHA1)
Length = 365
Score = 48.4 bits (110), Expect = 2e-04
Identities = 51/167 (30%), Positives = 75/167 (44%), Gaps = 17/167 (10%)
Frame = +2
Query: 221 GDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSA------PLED-VVNSIAVNKI 379
GDG+G E+V A Q V AA + + + E+ L A P+ D ++++
Sbjct: 18 GDGIGHEIVPATQRVVSAAVVAAGGGAVDWVELPLGLGAIESHGTPIPDSTLSALDALDA 77
Query: 380 CIKG---ILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIRE 550
I G A P+ G L T +R DL+AN+ +SL V D+D +I+RE
Sbjct: 78 WILGPHDSAAYPE-PFRGRL-TPGGVVRKRFDLFANIRPARSLEGVASTVPDMDLVIVRE 135
Query: 551 QTEGEYS-------ALEHESVPGVVECLKIITAAKSERIAKFAFDYA 670
TEG Y+ + E P V + ++T ERIA AF A
Sbjct: 136 NTEGLYADRNMFAGSGEFMPTPDVALAVGVVTRKACERIAHTAFALA 182
>UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2;
Bacillaceae|Rep: Tartrate dehydrogenase - Bacillus sp.
B14905
Length = 362
Score = 48.0 bits (109), Expect = 3e-04
Identities = 45/175 (25%), Positives = 73/175 (41%), Gaps = 14/175 (8%)
Frame = +2
Query: 200 IKCTLIPGDGVGPELVYAVQEVFKA-----ASIPVDFESFFFSEVNPTLSAPL--EDVVN 358
IK +IPGDG+G E++ +V K +S+ + F +S + ED +
Sbjct: 4 IKMAVIPGDGIGKEVMQEALKVVKCVQERDSSLQITTMVFPWSSDYYLAHGRMMPEDALE 63
Query: 359 SIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVK---CRHQDV 529
++ + G + + L M +R Y N +KSLP + D+
Sbjct: 64 TLQKYDAILFGAIGDARVPDDVTVWELIMPIRKNFQQYVNFRPIKSLPGISSPLAGGNDI 123
Query: 530 DCIIIREQTEGEYS----ALEHESVPGVVECLKIITAAKSERIAKFAFDYAVEDG 682
D +I RE EGEYS L + + I+T E+I + A +YA + G
Sbjct: 124 DFVIFRENAEGEYSDSGGRLYQQQPQEMTIQNTIMTRIGIEKIVRAACEYAQQHG 178
>UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;
n=4; cellular organisms|Rep: LeuB-1 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 354
Score = 48.0 bits (109), Expect = 3e-04
Identities = 46/176 (26%), Positives = 81/176 (46%), Gaps = 14/176 (7%)
Frame = +2
Query: 197 RIKCTLIPGDGVGPELVYAVQEVFK----AASIPVDFESF-FFSEVNPTLSAPLED-VVN 358
+++ +IPGDG+G E+V +V K + + +F+ + F +E L D +
Sbjct: 2 KLRIAVIPGDGIGKEVVAEGLKVLKKLEELSRVSFEFKEYPFGAEHYLKTGETLPDWAIE 61
Query: 359 SIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVK----SLPNVKCRHQD 526
G + P + + +K+R LDLY N+ VK L +K +++
Sbjct: 62 EFKKFDAIYFGAIGDPRVKPGILERGILLKMRFELDLYVNLRPVKLYHPRLTPLKGKNK- 120
Query: 527 VDCIIIREQTEGEYS---ALEHESVPGVVECLKII-TAAKSERIAKFAFDYAVEDG 682
+D + +RE TEG Y+ + P + ++I T ER+ +FAF+YA G
Sbjct: 121 IDIVFVRENTEGLYAGAGGFLRKGTPQEIAVQEMINTRFGVERVIRFAFEYAKRSG 176
>UniRef50_Q58991 Cluster: Threo-isocitrate dehydrogenase [NAD]; n=9;
Methanococcales|Rep: Threo-isocitrate dehydrogenase
[NAD] - Methanococcus jannaschii
Length = 347
Score = 48.0 bits (109), Expect = 3e-04
Identities = 43/172 (25%), Positives = 78/172 (45%), Gaps = 12/172 (6%)
Frame = +2
Query: 200 IKCTLIPGDGVGPELV-YAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAVNK 376
+K +I GDG+G E++ A++ + + + + +A ED +
Sbjct: 2 MKVCVIEGDGIGKEVIPEAIKILNELGEFEIIKGEAGLECLKKYGNALPEDTIEKAKEAD 61
Query: 377 ICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKC----------RHQD 526
I + G + +P ++ + LR LYANV + + + ++
Sbjct: 62 IILFGAITSPKPGEVQNYKSPIITLRKMFHLYANVRPINNFGIGQLIGKIADYEFLNAKN 121
Query: 527 VDCIIIREQTEGEYSALEH-ESVPGVVECLKIITAAKSERIAKFAFDYAVED 679
+D +IIRE TE Y E E+ + E ++IT SERI +FAF+YA+++
Sbjct: 122 IDIVIIRENTEDLYVGRERLENDTAIAE--RVITRKGSERIIRFAFEYAIKN 171
>UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: LeuB
protein - Bradyrhizobium japonicum
Length = 359
Score = 47.2 bits (107), Expect = 4e-04
Identities = 56/183 (30%), Positives = 89/183 (48%), Gaps = 20/183 (10%)
Frame = +2
Query: 212 LIPGDGVGPELVYAVQEVFKAASIP-----VDFES---FFFSEVNPTLSAPLED--VVNS 361
++ GDG+GPE+ A V +A VD+ + F + +A E ++
Sbjct: 9 VVHGDGIGPEVARAAVAVLQAGVQAGTLRFVDYPAGADHFLKTGDSFPAASFEGCRTADA 68
Query: 362 IAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVK---SLPNVKCRHQDVD 532
I I G++ PD + G TL ++ + LDL+ANV +K +P+ R +D
Sbjct: 69 ILHGAAGIPGVVH-PDGTEAGLDFTLTLRFK--LDLFANVRPIKLYKGVPSPLGRPGPID 125
Query: 533 CIIIREQTEGEYS-----ALEHESVPGVVECLKIITAAKSERIAKFAFDYA-VEDG-PQE 691
+I+RE +EG Y+ AL E V V+ L + T ERI +FAF+ A +G P++
Sbjct: 126 YVIVRENSEGLYAARGAGALLREEV--AVDTL-VQTRKGVERIVRFAFELARTRNGSPKD 182
Query: 692 GHR 700
G R
Sbjct: 183 GRR 185
>UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase,
mitochondrial precursor; n=33; Dikarya|Rep:
Homoisocitrate dehydrogenase, mitochondrial precursor -
Saccharomyces cerevisiae (Baker's yeast)
Length = 371
Score = 47.2 bits (107), Expect = 4e-04
Identities = 46/167 (27%), Positives = 79/167 (47%), Gaps = 12/167 (7%)
Frame = +2
Query: 212 LIPGDGVGPELVYAVQEVFKAAS----IPVDFESFF--FSEVNPTLSAPLEDVVNSIAVN 373
LIPGDG+G E++ A ++V + + + +F + F T A ++ V +
Sbjct: 28 LIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFIDLYAGFQTFQETGKALPDETVKVLKEQ 87
Query: 374 -KICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIRE 550
+ + G + +P G + + LR + L+ANV VKS+ K + +D +I+RE
Sbjct: 88 CQGALFGAVQSPTTKVEGYSSPI-VALRREMGLFANVRPVKSVEGEK--GKPIDMVIVRE 144
Query: 551 QTEGEYSALEH---ESVPG--VVECLKIITAAKSERIAKFAFDYAVE 676
TE Y +E + G V + K I+ + RIA A D A++
Sbjct: 145 NTEDLYIKIEKTYIDKATGTRVADATKRISEIATRRIATIALDIALK 191
>UniRef50_Q6L2P9 Cluster: Isocitrate dehydrogenase [NADP]; n=2;
Thermoplasmatales|Rep: Isocitrate dehydrogenase [NADP] -
Picrophilus torridus
Length = 392
Score = 46.8 bits (106), Expect = 6e-04
Identities = 36/130 (27%), Positives = 66/130 (50%), Gaps = 10/130 (7%)
Frame = +2
Query: 221 GDGVGPELVYAVQEVFKAASI----PVDFESFFFSEVNPTLSAPL--EDVVNSIAVNKIC 382
GDG+GPE++ A ++V AA+ + ++ + L E+ + +I ++
Sbjct: 24 GDGIGPEIMDATRKVVDAATAMEKKSIAWKEILLGDRAEELKGDRFPEESIKAINDYRVL 83
Query: 383 IKGILATPDFSHTGE-LQTLNMKLRNALDLYANVVHVKSLPNVKC---RHQDVDCIIIRE 550
+K L TP G+ +++N+++R LDLYAN+ VK +P ++ + V+ I RE
Sbjct: 84 LKAPLNTP----VGKGFKSINVRIRMLLDLYANIRPVKFMPGLESPLKNPEKVNLTIFRE 139
Query: 551 QTEGEYSALE 580
T+ Y E
Sbjct: 140 NTDDLYLGYE 149
>UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2;
Alphaproteobacteria|Rep: Isopropylmalate dehydrogenase -
Oceanicola granulosus HTCC2516
Length = 363
Score = 46.0 bits (104), Expect = 0.001
Identities = 37/130 (28%), Positives = 61/130 (46%), Gaps = 8/130 (6%)
Frame = +2
Query: 197 RIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAVNK 376
R+K ++ GD +G E+V A EV +AA+ +++V P +A LE +++
Sbjct: 5 RLKLGILNGDDIGHEIVPASVEVARAAAGKAGL-GIDWTDV-PIGAAALESHGHTMPEGT 62
Query: 377 I--------CIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVD 532
+ I G + D+ + LR DL+ANV +S P + C D+D
Sbjct: 63 METLEGLDGWILGPIGHRDYPKVPGAINPHPILRKGFDLFANVRPTRSYPGIGCLFDDID 122
Query: 533 CIIIREQTEG 562
+I+RE EG
Sbjct: 123 LVIVRENNEG 132
>UniRef50_A1SM34 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Nocardioides sp. JS614|Rep: 3-isopropylmalate
dehydrogenase - Nocardioides sp. (strain BAA-499 /
JS614)
Length = 478
Score = 45.2 bits (102), Expect = 0.002
Identities = 48/174 (27%), Positives = 78/174 (44%), Gaps = 18/174 (10%)
Frame = +2
Query: 194 GRIKCTLIPGDGVGPELVYAVQEVFKAAS-IPVDFESFFF----------SEVNPTLSAP 340
G ++ +IPGDG+GPE+ +V + AS V FE + EV P +
Sbjct: 130 GSLRLAVIPGDGIGPEVTAEALKVLEVASPAGVKFEQTRYDLGAERYLATGEVLP--DSV 187
Query: 341 LEDVVNSIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVK--- 511
LE++ A+ + G P+ + L ++LR LD Y N+ + P V
Sbjct: 188 LEEIREHDAILLGAVGGKPNDPNLPPGILERGLLLRLRFELDHYVNLRPSRIFPGVASPL 247
Query: 512 CRHQDVDCIIIREQTEGEYS----ALEHESVPGVVECLKIITAAKSERIAKFAF 661
+VD +++RE TEG Y+ AL + + + + TA ER+ + AF
Sbjct: 248 ANPGEVDFVVVREGTEGPYTGNGGALRVGTPHEIATEVSVNTAFGVERVVRDAF 301
>UniRef50_A0P1S6 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Rhodobacterales|Rep: 3-isopropylmalate dehydrogenase -
Stappia aggregata IAM 12614
Length = 369
Score = 45.2 bits (102), Expect = 0.002
Identities = 48/175 (27%), Positives = 77/175 (44%), Gaps = 18/175 (10%)
Frame = +2
Query: 200 IKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNP------TLSAPLEDVVNS 361
+K LI GDG+G ++ A V + A + + E+ +ED
Sbjct: 1 MKIALIKGDGIGVDVAEAAIAVLETALKHTGEPAPRYDEIQAGAGYFKETGLDIEDGGEE 60
Query: 362 IA-VNKICIKGILATPDFSHTGELQ-TLNMKLRNALDLYANVVHVKSLPNVKCRHQD--- 526
A + G + P H + + +++LR+ LYA V VK+ PN R D
Sbjct: 61 RAGLADAIFLGAIGLPSIRHANGTEISPHLRLRDRFGLYAGVRPVKAYPNAPQRLADPRA 120
Query: 527 --VDCIIIREQTEG-EYSALEHESVPGV----VECLKIITAAKSERIAKFAFDYA 670
+D +I+RE TEG YSA H+ V V+ + IT + ++ +FAF+ A
Sbjct: 121 AGIDLVILRESTEGLFYSAAAHKRSLVVNDDEVQDVLRITRKTTTKLHRFAFNLA 175
>UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular
organisms|Rep: Tartrate dehydrogenase - Burkholderia
mallei (Pseudomonas mallei)
Length = 361
Score = 44.8 bits (101), Expect = 0.002
Identities = 46/176 (26%), Positives = 78/176 (44%), Gaps = 20/176 (11%)
Frame = +2
Query: 203 KCTLIPGDGVG----PELVYAVQEVFKAASI-----PVDFESFFFSEVNPTLSAPLEDVV 355
+ +IPGDG+G PE + A+ V + + P+++ S + + + +D
Sbjct: 7 RIAVIPGDGIGVEVMPEGLRALDAVSRRFGLRFAYEPIEWASCDYYAKHGQMMP--DDWK 64
Query: 356 NSIAVNKICIKGILATPDF--SHTGELQTLNMKLRNALDLYANVVHVKSLPNVKC----- 514
++ + G + P+ H +L +K R D Y N+ + V C
Sbjct: 65 TQLSGMDALLFGAVGWPETVPDHISLWGSL-IKFRREFDQYVNLRPARLFDGVPCPLAGR 123
Query: 515 RHQDVDCIIIREQTEGEYSALEHESVPGV----VECLKIITAAKSERIAKFAFDYA 670
+ D+D +I+RE TEGEYSA+ G V + T +ER+ KFAF+ A
Sbjct: 124 KAGDIDFMIVRENTEGEYSAVGGTMFEGTEREFVVQQAVFTRHGTERVLKFAFELA 179
>UniRef50_Q8FPV5 Cluster: 3-isopropylmalate dehydrogenase; n=50;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Corynebacterium efficiens
Length = 340
Score = 43.2 bits (97), Expect = 0.007
Identities = 39/167 (23%), Positives = 74/167 (44%), Gaps = 10/167 (5%)
Frame = +2
Query: 200 IKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPL--EDVVNSIAVN 373
+K +I GDG+GPE+ +V +A ++ + L ++ + + +
Sbjct: 1 MKLAVIGGDGIGPEVTDEALKVLRALRADIETTDLDLGARRYLRNGELLTDEDLALLREH 60
Query: 374 KICIKGILATPDFSHTGELQT-LNMKLRNALDLYANVVHVKSLPNVKC---RHQDVDCII 541
+ G + P G L+ L +KLR ALD + N+ K V+ ++D ++
Sbjct: 61 DAILLGAIGAPGSVPPGVLERGLLLKLRFALDHHVNLRPSKLYEGVESPLKNPGEIDFVV 120
Query: 542 IREQTEGEYS----ALEHESVPGVVECLKIITAAKSERIAKFAFDYA 670
+RE TEG Y+ A+ + + T +ER+ ++AF+ A
Sbjct: 121 VREGTEGAYTGNGGAIRVGTPHETANETSVNTRYGAERVIRYAFELA 167
>UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=38; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Synechocystis sp. (strain PCC 6803)
Length = 475
Score = 42.3 bits (95), Expect = 0.013
Identities = 28/82 (34%), Positives = 40/82 (48%), Gaps = 3/82 (3%)
Frame = +2
Query: 344 EDVVNSIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRH- 520
ED + +I + IKG L TP G +++LN+ LR DLY V + P H
Sbjct: 86 EDTLTAIKEYGVAIKGPLTTP---VGGGIRSLNVALRQIFDLYTCVRPCRYYPGTPSPHK 142
Query: 521 --QDVDCIIIREQTEGEYSALE 580
+ +D I+ RE TE Y +E
Sbjct: 143 TPEKLDIIVYRENTEDIYLGIE 164
>UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for
NADP+; n=3; Alteromonadales|Rep: Isocitrate
dehydrogenase, specific for NADP+ - Alteromonadales
bacterium TW-7
Length = 422
Score = 40.7 bits (91), Expect = 0.038
Identities = 27/96 (28%), Positives = 52/96 (54%), Gaps = 3/96 (3%)
Frame = +2
Query: 344 EDVVNSIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVK---SLPNVKC 514
++ + ++ KI IKG L TP G ++LN+ LR +DL+ N+ +K +LP+
Sbjct: 87 QETIQAVRACKIAIKGPLTTP---LGGGFRSLNVALRQEMDLFVNMRTIKGFSALPSPLK 143
Query: 515 RHQDVDCIIIREQTEGEYSALEHESVPGVVECLKII 622
+ ++R+ +E YS +E ++ G +E K++
Sbjct: 144 NPFLTNITVLRDSSEDVYSGIEWQA--GSIESEKML 177
>UniRef50_P56471 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 90
Score = 40.7 bits (91), Expect = 0.038
Identities = 16/27 (59%), Positives = 21/27 (77%)
Frame = +2
Query: 209 TLIPGDGVGPELVYAVQEVFKAASIPV 289
TLIPGDG+GPE+ AV ++F AA P+
Sbjct: 8 TLIPGDGIGPEISAAVMKIFDAAKAPI 34
>UniRef50_Q89RJ1 Cluster: 3-isopropylmalate dehydrogenase; n=7;
Alphaproteobacteria|Rep: 3-isopropylmalate dehydrogenase
- Bradyrhizobium japonicum
Length = 368
Score = 39.9 bits (89), Expect = 0.067
Identities = 41/167 (24%), Positives = 69/167 (41%), Gaps = 14/167 (8%)
Frame = +2
Query: 212 LIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPL-------EDVVNSIAV 370
++ GDG+GPE++ EV + D F F+E + L E +
Sbjct: 20 VLAGDGIGPEVMAPAIEVLRKIEQKSDLR-FRFTEAPAGANNYLATGKSMPERTIKLCEE 78
Query: 371 NKICIKGILATPDFSHTGELQTL-NMKLRNALDLYANVVHVKSLPNVK-----CRHQDVD 532
+ G P + + ++LR DLYA V + +P V + +D
Sbjct: 79 ADAILLGACGLPSVRYPDNTEIAPQIELRFIFDLYAGVRPARLIPGVPSPIVGADTRGID 138
Query: 533 CIIIREQTEGEYSALEHESVPGV-VECLKIITAAKSERIAKFAFDYA 670
++IRE TEG ++++ V +IT SER+ +F+F A
Sbjct: 139 LVVIRESTEGLFASMGKGVVTHEDARETMVITRRTSERLFEFSFRLA 185
>UniRef50_Q2VF40 Cluster: Isocitrate dehydrogenase 3 gamma subunit;
n=1; Pan troglodytes|Rep: Isocitrate dehydrogenase 3
gamma subunit - Pan troglodytes (Chimpanzee)
Length = 165
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/32 (53%), Positives = 22/32 (68%)
Frame = +2
Query: 176 PRATKEGRIKCTLIPGDGVGPELVYAVQEVFK 271
P A GR T+IPGDG+GPEL+ V+ VF+
Sbjct: 105 PSAKYGGRHTVTMIPGDGIGPELMLHVKSVFR 136
>UniRef50_A6G3V7 Cluster: Probable 3-isopropylmalate dehydrogenase;
n=1; Plesiocystis pacifica SIR-1|Rep: Probable
3-isopropylmalate dehydrogenase - Plesiocystis pacifica
SIR-1
Length = 368
Score = 38.3 bits (85), Expect = 0.20
Identities = 30/85 (35%), Positives = 43/85 (50%), Gaps = 14/85 (16%)
Frame = +2
Query: 452 RNALDLYANVVHVKSLPNVKCR----HQD------VDCIIIREQTEGEYSALEHESVPG- 598
R L+LYANV +K P V+ R H+ VD +IIRE TEG Y+ + PG
Sbjct: 87 RMRLNLYANVRPIKLYPGVQHRIHGGHKQIWEAGKVDMVIIRENTEGLYAPTGGKLAPGG 146
Query: 599 ---VVECLKIITAAKSERIAKFAFD 664
V ++IT E++ + AF+
Sbjct: 147 KADVAIDTRVITRRACEQVIRHAFE 171
>UniRef50_Q8DTG3 Cluster: 3-isopropylmalate dehydrogenase; n=41;
Bacilli|Rep: 3-isopropylmalate dehydrogenase -
Streptococcus mutans
Length = 344
Score = 38.3 bits (85), Expect = 0.20
Identities = 43/170 (25%), Positives = 74/170 (43%), Gaps = 14/170 (8%)
Frame = +2
Query: 203 KCTLIPGDGVGPELVYAVQEVFKAASIPVDF----ESFFFSEVNPTLSA-PL-EDVVNSI 364
K + GDG+GPE++ A EVF A + ++F E+ F S PL +D + +
Sbjct: 3 KIVTLAGDGIGPEIMAAGLEVFDAVAQKINFDYEIEAKAFGGAGIDASGHPLPDDTLAAA 62
Query: 365 AVNKICIKGILATPDFSHTGELQTLN-MKLRNALDLYANVVHV------KSLPNVKC-RH 520
+ + +P + + +R L+L+AN+ V + L +K R
Sbjct: 63 KTADAILLAAIGSPQYDKAPVRPEQGLLAIRKELNLFANIRPVRIFDALRHLSPLKAERI 122
Query: 521 QDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYA 670
VD +++RE T G Y +H + +A++ RI + AF A
Sbjct: 123 AGVDFVVVRELTGGIYFG-QHTLTENSACDINEYSASEIRRIMRKAFAIA 171
>UniRef50_Q7UTP0 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodopirellula baltica
Length = 364
Score = 37.9 bits (84), Expect = 0.27
Identities = 39/169 (23%), Positives = 68/169 (40%), Gaps = 16/169 (9%)
Frame = +2
Query: 212 LIPGDGVGPE-------LVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNSIAV 370
++ GDG+GPE L+ +Q +D S E + A + ++
Sbjct: 9 ILGGDGIGPEVCDQSVRLLEIMQPHLDGVEFQLDRHSVGVGEYQRSGEALPQSAYDACLA 68
Query: 371 NKICIKGILATPDFSH-TGELQTLNMKLRNALDLYANV-----VHVKSLPNVKCRHQDVD 532
+ + G + P+ + G+ + LR L LY V H P ++D
Sbjct: 69 SDAVLLGAMGLPNVRYPNGKEIAPQLDLRERLQLYGGVRPIRLYHEADTPLKGHGPGEID 128
Query: 533 CIIIREQTEGEY---SALEHESVPGVVECLKIITAAKSERIAKFAFDYA 670
+++RE TEG + A+ L+ IT + SER+ + AF+ A
Sbjct: 129 FVLVRESTEGLFYGRDAIADLEADEATNLLR-ITRSASERVCRLAFETA 176
>UniRef50_Q5IWY1 Cluster: Plastid 3-isopropylmalate dehydrogenase;
n=1; Prototheca wickerhamii|Rep: Plastid
3-isopropylmalate dehydrogenase - Prototheca wickerhamii
Length = 211
Score = 37.1 bits (82), Expect = 0.47
Identities = 40/142 (28%), Positives = 64/142 (45%), Gaps = 20/142 (14%)
Frame = +2
Query: 203 KCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEV-----------NPTLSAPLED 349
+ T++PGDG+GPE+ V +AA + ESF F+E +P A
Sbjct: 40 RVTVLPGDGIGPEITAVTLSVLEAAG-KAEGESFTFTEALIGGAAYDATGDPYPDATYRA 98
Query: 350 VVNSIAVNKICIKGIL--ATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRH- 520
+S AV I G A P S + +T ++LR++L+ +AN+ +P +
Sbjct: 99 CADSDAVLLAAIGGYKWDALPSVS---KPETGLLRLRSSLNAFANLRPATVIPELADASS 155
Query: 521 ------QDVDCIIIREQTEGEY 568
+ VD +I+RE G Y
Sbjct: 156 LKREVLEGVDLLIVRELVGGIY 177
>UniRef50_Q6L0K7 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Thermoplasmatales|Rep: 3-isopropylmalate dehydrogenase -
Picrophilus torridus
Length = 335
Score = 37.1 bits (82), Expect = 0.47
Identities = 32/135 (23%), Positives = 61/135 (45%), Gaps = 2/135 (1%)
Frame = +2
Query: 200 IKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPL--EDVVNSIAVN 373
+ LIPGDG+G E++ V + S ++F +F S + + +D + +
Sbjct: 2 VDVALIPGDGIGREIMPGVAAAISSIS-DINFVTFDISSERYIKTGIIIKDDELEELKNY 60
Query: 374 KICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDCIIIREQ 553
+ + G + P Q + ++LR L+LY N+ V+S + + I+RE
Sbjct: 61 RAILFGAIGDPRVRPGIMEQGVILRLRRELELYMNIRPVRSFDD------KIKITILREN 114
Query: 554 TEGEYSALEHESVPG 598
T+ Y+ + +PG
Sbjct: 115 TQDFYTDIS-GIIPG 128
>UniRef50_A3VUI2 Cluster: Putative dipeptidyl peptidase IV; n=1;
Parvularcula bermudensis HTCC2503|Rep: Putative
dipeptidyl peptidase IV - Parvularcula bermudensis
HTCC2503
Length = 739
Score = 36.3 bits (80), Expect = 0.82
Identities = 23/75 (30%), Positives = 34/75 (45%), Gaps = 1/75 (1%)
Frame = +2
Query: 524 DVDCIIIREQTEGEYSALEHESV-PGVVECLKIITAAKSERIAKFAFDYAVEDGPQEGHR 700
D D ++R+ T G++ V G ITA+K + I + F +E G E
Sbjct: 363 DGDGTLLRQITSGDWPVASINCVNEGEAGGALYITASKDQAIEQHLFRVPLEGGAPEQLT 422
Query: 701 CPQGQHHGSWATDCS 745
G H GS++ DCS
Sbjct: 423 TEAGWHGGSYSADCS 437
>UniRef50_A5ADY5 Cluster: Putative uncharacterized protein; n=6; Vitis
vinifera|Rep: Putative uncharacterized protein - Vitis
vinifera (Grape)
Length = 1303
Score = 35.9 bits (79), Expect = 1.1
Identities = 27/78 (34%), Positives = 43/78 (55%), Gaps = 1/78 (1%)
Frame = +2
Query: 359 SIAVNKIC-IKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDC 535
S+A ++I ++G+LA DFS T + L+ +A+ + AN V+ + + +H +VDC
Sbjct: 1198 SLACSEIIWLRGLLAELDFSET-DPTPLHADNTSAIQITANPVY-----HERTKHIEVDC 1251
Query: 536 IIIREQTEGEYSALEHES 589
IRE E AL H S
Sbjct: 1252 HSIREAFEARVIALPHIS 1269
>UniRef50_Q54WR2 Cluster: Putative uncharacterized protein; n=2;
cellular organisms|Rep: Putative uncharacterized protein
- Dictyostelium discoideum AX4
Length = 2667
Score = 35.9 bits (79), Expect = 1.1
Identities = 22/96 (22%), Positives = 45/96 (46%), Gaps = 7/96 (7%)
Frame = +2
Query: 326 TLSAPLEDVVNSIAVNKICIKGILATPDFSHTGELQTLNMKLRNALDLYANV-VHVKSLP 502
T P D+ + +K I + A+ F HT K +A+DL + + VKS P
Sbjct: 551 TTGVPKNDIFTKYSTDKTTISNLYASTSFLHTDGFIQRTSKKDHAIDLLLTLFLRVKSFP 610
Query: 503 NVKCRHQD------VDCIIIREQTEGEYSALEHESV 592
++K + ++C++ + + ++SA++ S+
Sbjct: 611 SIKLNDKSPLYSSVLNCLLHSQWSVSKHSAIKIRSI 646
>UniRef50_Q973N4 Cluster: Putative uncharacterized protein ST0866;
n=1; Sulfolobus tokodaii|Rep: Putative uncharacterized
protein ST0866 - Sulfolobus tokodaii
Length = 344
Score = 35.9 bits (79), Expect = 1.1
Identities = 27/107 (25%), Positives = 53/107 (49%), Gaps = 1/107 (0%)
Frame = +2
Query: 182 ATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSAPLEDVVNS 361
A K G++K I G+ P + ++E+ ASI ++ +FF ++NP + ++
Sbjct: 23 AEKAGKMKFNEI-WSGIDPNYIDGIKEI---ASIAEKYDMYFFVDINPEIMRGFGASPSN 78
Query: 362 IAVNK-ICIKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSL 499
+ V K + IKG+ A F+ ++ N L ++L A++ + L
Sbjct: 79 LKVFKELKIKGLRADYGFTIDDLIKMANNNLDLVIELNASIFPLDKL 125
>UniRef50_Q9LTT4 Cluster: WD domain protein-like; n=5;
Magnoliophyta|Rep: WD domain protein-like - Arabidopsis
thaliana (Mouse-ear cress)
Length = 418
Score = 34.7 bits (76), Expect = 2.5
Identities = 19/63 (30%), Positives = 28/63 (44%), Gaps = 2/63 (3%)
Frame = -3
Query: 675 STA*SKANFAIRSDFAAVMIFKHSTTPGTDSCSKAEYSPSVC--SLMMMQSTSWCLHFTL 502
ST K +F + F +I KH PG CS+ Y + ++ + S LHFT
Sbjct: 165 STLAVKDDFLVAGGFQGELICKHLDRPGVSFCSRMTYDDNAITNAIEIYNKPSGALHFTA 224
Query: 501 GND 493
N+
Sbjct: 225 SNN 227
>UniRef50_A4A615 Cluster: Flagellar hook protein FlgE; n=2;
unclassified Gammaproteobacteria|Rep: Flagellar hook
protein FlgE - Congregibacter litoralis KT71
Length = 429
Score = 34.3 bits (75), Expect = 3.3
Identities = 24/72 (33%), Positives = 29/72 (40%)
Frame = +2
Query: 116 GSQHVGKGVHTSSVTTEKNQPRATKEGRIKCTLIPGDGVGPELVYAVQEVFKAASIPVDF 295
GS +GKGV + VT E Q T I G+G V E +A + VD
Sbjct: 51 GSNAIGKGVSLAGVTQEFGQGNITFTNNSLDLAINGNGFFQLSVEGAVEYTRAGNFQVDR 110
Query: 296 ESFFFSEVNPTL 331
E F S N L
Sbjct: 111 EGFLVSNQNARL 122
>UniRef50_A5BJM5 Cluster: Putative uncharacterized protein; n=8; Vitis
vinifera|Rep: Putative uncharacterized protein - Vitis
vinifera (Grape)
Length = 1308
Score = 34.3 bits (75), Expect = 3.3
Identities = 26/78 (33%), Positives = 42/78 (53%), Gaps = 1/78 (1%)
Frame = +2
Query: 359 SIAVNKIC-IKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDC 535
S+A ++I ++G+LA DFS T + L+ +A+ + AN V+ + + +H +VDC
Sbjct: 1177 SLACSEIIWLRGLLAELDFSET-DPTPLHADNTSAIQITANPVY-----HERTKHIEVDC 1230
Query: 536 IIIREQTEGEYSALEHES 589
IRE E L H S
Sbjct: 1231 HSIREAFEARVITLPHIS 1248
>UniRef50_Q0W5L4 Cluster: 3-isopropylmalate dehydrogenase; n=10;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Uncultured methanogenic archaeon RC-I
Length = 380
Score = 34.3 bits (75), Expect = 3.3
Identities = 37/147 (25%), Positives = 62/147 (42%), Gaps = 15/147 (10%)
Frame = +2
Query: 203 KCTLIPGDGVGPE-------LVYAVQEV--FKAASIPVDFESFFFSEVNPTLSAPLEDVV 355
K +I GDG+GPE ++ A QEV F I + F + + + T+S E +
Sbjct: 5 KVPVIAGDGIGPEVIAEGRKVIAAAQEVYNFDVEWIDMPFSADHYVKTGETIS---ESSL 61
Query: 356 NSIAVNKICIKGILATPDFSHTGELQT-LNMKLRNALDLYANVVHVKSLPNVKC-----R 517
++ + G + G L+ + + +R D Y N+ VK + V+
Sbjct: 62 KELSKYRAIFLGSIGDDRKVKPGVLEKGILLTMRFYYDQYVNLRPVKLMEGVETPLKGKT 121
Query: 518 HQDVDCIIIREQTEGEYSALEHESVPG 598
D+D ++RE TE Y + S G
Sbjct: 122 AADIDFYVVRENTEDFYVGIGGRSKKG 148
>UniRef50_P56472 Cluster: Isocitrate dehydrogenase [NAD] subunit
beta, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit beta,
mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase)
(NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 103
Score = 34.3 bits (75), Expect = 3.3
Identities = 14/22 (63%), Positives = 17/22 (77%)
Frame = +2
Query: 191 EGRIKCTLIPGDGVGPELVYAV 256
EG T++PGDGVGPEL+ AV
Sbjct: 12 EGAFPVTMLPGDGVGPELMAAV 33
>UniRef50_A5BSB2 Cluster: Putative uncharacterized protein; n=2;
Vitis vinifera|Rep: Putative uncharacterized protein -
Vitis vinifera (Grape)
Length = 698
Score = 33.9 bits (74), Expect = 4.4
Identities = 25/78 (32%), Positives = 41/78 (52%), Gaps = 1/78 (1%)
Frame = +2
Query: 359 SIAVNKIC-IKGILATPDFSHTGELQTLNMKLRNALDLYANVVHVKSLPNVKCRHQDVDC 535
S+A ++I ++G+LA DFS T + L+ +A+ + N V+ + + +H +VDC
Sbjct: 593 SLACSEIIWLRGLLAALDFSET-DPTPLHTDNTSAIQITTNPVY-----HERTKHIEVDC 646
Query: 536 IIIREQTEGEYSALEHES 589
IRE E L H S
Sbjct: 647 YSIREAFEAHVITLPHIS 664
>UniRef50_Q5T6L9 Cluster: Transmembrane protein C6orf70; n=39;
Amniota|Rep: Transmembrane protein C6orf70 - Homo
sapiens (Human)
Length = 678
Score = 33.5 bits (73), Expect = 5.8
Identities = 18/54 (33%), Positives = 26/54 (48%)
Frame = -1
Query: 260 LVQRRQARVLHHPQESRCI*YDLPLLPSVDFSPLLPNLCVHPFQHVEIPA*QLE 99
L+ + + HH E+RC+ DL LP+ + LL LC P + P LE
Sbjct: 478 LITKMTDELYHHMPENRCVLKDLDRLPTETWPQLLRELCSTPVPTLFCPRIVLE 531
>UniRef50_Q4GYN8 Cluster: Putative uncharacterized protein; n=1;
Trypanosoma brucei|Rep: Putative uncharacterized protein
- Trypanosoma brucei
Length = 156
Score = 33.1 bits (72), Expect = 7.7
Identities = 14/39 (35%), Positives = 22/39 (56%)
Frame = -1
Query: 230 HHPQESRCI*YDLPLLPSVDFSPLLPNLCVHPFQHVEIP 114
H P S+ + DLP +P+ FSPL P++ P ++P
Sbjct: 110 HSPTHSKELALDLPFIPTFLFSPLSPHMVSTPVSGSQVP 148
>UniRef50_Q12592 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Ascomycota|Rep: 3-isopropylmalate dehydrogenase -
Candida maltosa (Yeast)
Length = 251
Score = 33.1 bits (72), Expect = 7.7
Identities = 27/102 (26%), Positives = 47/102 (46%), Gaps = 11/102 (10%)
Frame = +2
Query: 209 TLIPGDGVGPELVYAVQEVFKAASIPVDFESFFFSEVNPTLSA--------PL-EDVVNS 361
T++PGD VG E+V +V +A ++ F + + PL +D + S
Sbjct: 9 TILPGDHVGTEIVNEAIKVLEAIEAATPYQKIHFDFKHHLIGGAAIDATGVPLPDDALES 68
Query: 362 IAVNKICIKGILATPDFSHTGELQTLN--MKLRNALDLYANV 481
+ + G + P + TG L+ +K+R L+LYAN+
Sbjct: 69 AKNSDAVLLGAVGGPKWG-TGALRPEQGLLKIRKELNLYANI 109
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 771,597,364
Number of Sequences: 1657284
Number of extensions: 16391449
Number of successful extensions: 47370
Number of sequences better than 10.0: 98
Number of HSP's better than 10.0 without gapping: 44885
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 47255
length of database: 575,637,011
effective HSP length: 99
effective length of database: 411,565,895
effective search space used: 62969581935
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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