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Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= epV30683
         (722 letters)

Database: human 
           237,096 sequences; 76,859,062 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

BC019320-1|AAH19320.2|  427|Homo sapiens pseudouridylate synthas...    42   0.002
BC009505-1|AAH09505.2|  427|Homo sapiens pseudouridylate synthas...    42   0.002
BC002901-1|AAH02901.1|  399|Homo sapiens pseudouridylate synthas...    42   0.002
AF116238-1|AAD21042.1|  365|Homo sapiens pseudouridine synthase ...    42   0.002
J03250-1|AAA61207.1|  765|Homo sapiens TOP1 protein.                   32   1.8  
U07806-1|AAB60380.1|  761|Homo sapiens DNA topoisomerase I protein.    31   5.5  
U07804-1|AAB60379.1|  761|Homo sapiens DNA topoisomerase I protein.    31   5.5  
M60706-1|AAA61206.1|  765|Homo sapiens topoisomerase I protein.        31   5.5  
BC092404-1|AAH92404.1|  881|Homo sapiens Rap guanine nucleotide ...    31   5.5  
AL035652-1|CAI19767.1|  765|Homo sapiens topoisomerase (DNA) I p...    31   5.5  
AL022394-1|CAI42886.1|  765|Homo sapiens topoisomerase (DNA) I p...    31   5.5  
U78168-1|AAD12740.1|  881|Homo sapiens cAMP-regulated guanine nu...    30   7.3  
BC017728-1|AAH17728.1|  881|Homo sapiens Rap guanine nucleotide ...    30   7.3  
AF103905-1|AAC83381.1|  881|Homo sapiens Rap1 guanine-nucleotide...    30   7.3  

>BC019320-1|AAH19320.2|  427|Homo sapiens pseudouridylate synthase 1
           protein.
          Length = 427

 Score = 42.3 bits (95), Expect = 0.002
 Identities = 21/43 (48%), Positives = 31/43 (72%), Gaps = 1/43 (2%)
 Frame = +2

Query: 596 VSLKLPLEVNV-EEINKRLPETIKVFAVKRVTNRFNSKSKCNA 721
           VSLK+ L  ++ E+IN  LP  I++  +KRVT  FNSK++C+A
Sbjct: 156 VSLKVWLIDDILEKINSHLPSHIRILGLKRVTGGFNSKNRCDA 198



 Score = 37.5 bits (83), Expect = 0.048
 Identities = 22/70 (31%), Positives = 35/70 (50%), Gaps = 3/70 (4%)
 Frame = +3

Query: 372 ERIKRKKMAMLLGYSGVEYYGMQRNPG---VQTIXXXXXXXXXXXXYITQEDFENAQNAQ 542
           E+  ++K+ +L+ YSG  Y+GMQRN G    +TI             I +   E+ +   
Sbjct: 79  EKPPKRKIVLLMAYSGKGYHGMQRNVGSSQFKTIEDDLVSALVRSGCIPENHGEDMRKMS 138

Query: 543 FQRSSRD*QG 572
           FQR +R  +G
Sbjct: 139 FQRCARTDKG 148


>BC009505-1|AAH09505.2|  427|Homo sapiens pseudouridylate synthase 1
           protein.
          Length = 427

 Score = 42.3 bits (95), Expect = 0.002
 Identities = 21/43 (48%), Positives = 31/43 (72%), Gaps = 1/43 (2%)
 Frame = +2

Query: 596 VSLKLPLEVNV-EEINKRLPETIKVFAVKRVTNRFNSKSKCNA 721
           VSLK+ L  ++ E+IN  LP  I++  +KRVT  FNSK++C+A
Sbjct: 156 VSLKVWLIDDILEKINSHLPSHIRILGLKRVTGGFNSKNRCDA 198



 Score = 37.5 bits (83), Expect = 0.048
 Identities = 22/70 (31%), Positives = 35/70 (50%), Gaps = 3/70 (4%)
 Frame = +3

Query: 372 ERIKRKKMAMLLGYSGVEYYGMQRNPG---VQTIXXXXXXXXXXXXYITQEDFENAQNAQ 542
           E+  ++K+ +L+ YSG  Y+GMQRN G    +TI             I +   E+ +   
Sbjct: 79  EKPPKRKIVLLMAYSGKGYHGMQRNVGSSQFKTIEDDLVSALVRSGCIPENHGEDMRKMS 138

Query: 543 FQRSSRD*QG 572
           FQR +R  +G
Sbjct: 139 FQRCARTDKG 148


>BC002901-1|AAH02901.1|  399|Homo sapiens pseudouridylate synthase 1
           protein.
          Length = 399

 Score = 42.3 bits (95), Expect = 0.002
 Identities = 21/43 (48%), Positives = 31/43 (72%), Gaps = 1/43 (2%)
 Frame = +2

Query: 596 VSLKLPLEVNV-EEINKRLPETIKVFAVKRVTNRFNSKSKCNA 721
           VSLK+ L  ++ E+IN  LP  I++  +KRVT  FNSK++C+A
Sbjct: 128 VSLKVWLIDDILEKINSHLPSHIRILGLKRVTGGFNSKNRCDA 170



 Score = 37.5 bits (83), Expect = 0.048
 Identities = 22/70 (31%), Positives = 35/70 (50%), Gaps = 3/70 (4%)
 Frame = +3

Query: 372 ERIKRKKMAMLLGYSGVEYYGMQRNPG---VQTIXXXXXXXXXXXXYITQEDFENAQNAQ 542
           E+  ++K+ +L+ YSG  Y+GMQRN G    +TI             I +   E+ +   
Sbjct: 51  EKPPKRKIVLLMAYSGKGYHGMQRNVGSSQFKTIEDDLVSALVRSGCIPENHGEDMRKMS 110

Query: 543 FQRSSRD*QG 572
           FQR +R  +G
Sbjct: 111 FQRCARTDKG 120


>AF116238-1|AAD21042.1|  365|Homo sapiens pseudouridine synthase 1
           protein.
          Length = 365

 Score = 42.3 bits (95), Expect = 0.002
 Identities = 21/43 (48%), Positives = 31/43 (72%), Gaps = 1/43 (2%)
 Frame = +2

Query: 596 VSLKLPLEVNV-EEINKRLPETIKVFAVKRVTNRFNSKSKCNA 721
           VSLK+ L  ++ E+IN  LP  I++  +KRVT  FNSK++C+A
Sbjct: 94  VSLKVWLIDDILEKINSHLPSHIRILGLKRVTGGFNSKNRCDA 136



 Score = 37.5 bits (83), Expect = 0.048
 Identities = 22/70 (31%), Positives = 35/70 (50%), Gaps = 3/70 (4%)
 Frame = +3

Query: 372 ERIKRKKMAMLLGYSGVEYYGMQRNPG---VQTIXXXXXXXXXXXXYITQEDFENAQNAQ 542
           E+  ++K+ +L+ YSG  Y+GMQRN G    +TI             I +   E+ +   
Sbjct: 17  EKPPKRKIVLLMAYSGKGYHGMQRNVGSSQFKTIEDDLVSALVRSGCIPENHGEDMRKMS 76

Query: 543 FQRSSRD*QG 572
           FQR +R  +G
Sbjct: 77  FQRCARTDKG 86


>J03250-1|AAA61207.1|  765|Homo sapiens TOP1 protein.
          Length = 765

 Score = 32.3 bits (70), Expect = 1.8
 Identities = 16/48 (33%), Positives = 27/48 (56%)
 Frame = +3

Query: 252 KDEENKSIDIVPNKLLTRYNKRRAHRDWETKPPGEIKKPYERIKRKKM 395
           +DE++  +D  P K+ T   K+   R  E +  G++KKP  + K KK+
Sbjct: 140 RDEDD--VDYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKDKDKKV 185


>U07806-1|AAB60380.1|  761|Homo sapiens DNA topoisomerase I protein.
          Length = 761

 Score = 30.7 bits (66), Expect = 5.5
 Identities = 16/48 (33%), Positives = 26/48 (54%)
 Frame = +3

Query: 252 KDEENKSIDIVPNKLLTRYNKRRAHRDWETKPPGEIKKPYERIKRKKM 395
           +DE++   D  P K+ T   K+   R  E +  G++KKP  + K KK+
Sbjct: 136 RDEDDA--DYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKDKDKKV 181


>U07804-1|AAB60379.1|  761|Homo sapiens DNA topoisomerase I protein.
          Length = 761

 Score = 30.7 bits (66), Expect = 5.5
 Identities = 16/48 (33%), Positives = 26/48 (54%)
 Frame = +3

Query: 252 KDEENKSIDIVPNKLLTRYNKRRAHRDWETKPPGEIKKPYERIKRKKM 395
           +DE++   D  P K+ T   K+   R  E +  G++KKP  + K KK+
Sbjct: 136 RDEDDA--DYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKDKDKKV 181


>M60706-1|AAA61206.1|  765|Homo sapiens topoisomerase I protein.
          Length = 765

 Score = 30.7 bits (66), Expect = 5.5
 Identities = 16/48 (33%), Positives = 26/48 (54%)
 Frame = +3

Query: 252 KDEENKSIDIVPNKLLTRYNKRRAHRDWETKPPGEIKKPYERIKRKKM 395
           +DE++   D  P K+ T   K+   R  E +  G++KKP  + K KK+
Sbjct: 140 RDEDDA--DYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKDKDKKV 185


>BC092404-1|AAH92404.1|  881|Homo sapiens Rap guanine nucleotide
           exchange factor (GEF) 3 protein.
          Length = 881

 Score = 30.7 bits (66), Expect = 5.5
 Identities = 20/49 (40%), Positives = 25/49 (51%), Gaps = 2/49 (4%)
 Frame = -3

Query: 351 LEVWSPNRD--VPGVCCTSLIAYSALYRLTYFLHLSLRRQLPLRTASVR 211
           L VW PN+D  +PG  C   +     Y +    H  L  QLP+ TASVR
Sbjct: 494 LPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTMQLPV-TASVR 541


>AL035652-1|CAI19767.1|  765|Homo sapiens topoisomerase (DNA) I
           protein.
          Length = 765

 Score = 30.7 bits (66), Expect = 5.5
 Identities = 16/48 (33%), Positives = 26/48 (54%)
 Frame = +3

Query: 252 KDEENKSIDIVPNKLLTRYNKRRAHRDWETKPPGEIKKPYERIKRKKM 395
           +DE++   D  P K+ T   K+   R  E +  G++KKP  + K KK+
Sbjct: 140 RDEDDA--DYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKDKDKKV 185


>AL022394-1|CAI42886.1|  765|Homo sapiens topoisomerase (DNA) I
           protein.
          Length = 765

 Score = 30.7 bits (66), Expect = 5.5
 Identities = 16/48 (33%), Positives = 26/48 (54%)
 Frame = +3

Query: 252 KDEENKSIDIVPNKLLTRYNKRRAHRDWETKPPGEIKKPYERIKRKKM 395
           +DE++   D  P K+ T   K+   R  E +  G++KKP  + K KK+
Sbjct: 140 RDEDDA--DYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKDKDKKV 185


>U78168-1|AAD12740.1|  881|Homo sapiens cAMP-regulated guanine
           nucleotide exchange factor I protein.
          Length = 881

 Score = 30.3 bits (65), Expect = 7.3
 Identities = 20/49 (40%), Positives = 25/49 (51%), Gaps = 2/49 (4%)
 Frame = -3

Query: 351 LEVWSPNRD--VPGVCCTSLIAYSALYRLTYFLHLSLRRQLPLRTASVR 211
           L VW PN+D  +PG  C   +     Y +    H  L  QLP+ TASVR
Sbjct: 494 LPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPV-TASVR 541


>BC017728-1|AAH17728.1|  881|Homo sapiens Rap guanine nucleotide
           exchange factor (GEF) 3 protein.
          Length = 881

 Score = 30.3 bits (65), Expect = 7.3
 Identities = 20/49 (40%), Positives = 25/49 (51%), Gaps = 2/49 (4%)
 Frame = -3

Query: 351 LEVWSPNRD--VPGVCCTSLIAYSALYRLTYFLHLSLRRQLPLRTASVR 211
           L VW PN+D  +PG  C   +     Y +    H  L  QLP+ TASVR
Sbjct: 494 LPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPV-TASVR 541


>AF103905-1|AAC83381.1|  881|Homo sapiens Rap1 guanine-nucleotide
           exchange factor protein.
          Length = 881

 Score = 30.3 bits (65), Expect = 7.3
 Identities = 20/49 (40%), Positives = 25/49 (51%), Gaps = 2/49 (4%)
 Frame = -3

Query: 351 LEVWSPNRD--VPGVCCTSLIAYSALYRLTYFLHLSLRRQLPLRTASVR 211
           L VW PN+D  +PG  C   +     Y +    H  L  QLP+ TASVR
Sbjct: 494 LPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPV-TASVR 541


  Database: human
    Posted date:  Oct 23, 2007  1:18 PM
  Number of letters in database: 76,859,062
  Number of sequences in database:  237,096
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.279   0.0580    0.190 


Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 98,760,791
Number of Sequences: 237096
Number of extensions: 2056512
Number of successful extensions: 4161
Number of sequences better than 10.0: 14
Number of HSP's better than 10.0 without gapping: 4035
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4159
length of database: 76,859,062
effective HSP length: 88
effective length of database: 55,994,614
effective search space used: 8511181328
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)

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