Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= e96h0944
(709 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
AF263242-1|AAK58523.1| 320|Homo sapiens aldo-keto reductase loo... 76 2e-17
BC002862-1|AAH02862.1| 307|Homo sapiens AKR1CL2 protein protein. 76 2e-17
AB055603-1|BAC54568.1| 307|Homo sapiens aldo-keto reductase rel... 76 2e-17
CR542203-1|CAG47000.1| 316|Homo sapiens AKR1B1 protein. 85 3e-16
X15414-1|CAA33460.1| 316|Homo sapiens protein ( Human mRNA for ... 83 1e-15
M59783-1|AAA51712.1| 316|Homo sapiens aldose reductase protein. 83 1e-15
M34720-1|AAA35560.1| 316|Homo sapiens protein ( Human aldose re... 83 1e-15
J05474-1|AAA51715.1| 316|Homo sapiens aldose reductase protein. 83 1e-15
J05017-1|AAA51714.1| 316|Homo sapiens ALDR1 protein. 83 1e-15
J04795-1|AAA51713.1| 316|Homo sapiens ALDR1 protein. 83 1e-15
CR450351-1|CAG29347.1| 316|Homo sapiens AKR1B1 protein. 83 1e-15
BT019859-1|AAV38662.1| 316|Homo sapiens aldo-keto reductase fam... 83 1e-15
BC010391-1|AAH10391.1| 316|Homo sapiens aldo-keto reductase fam... 83 1e-15
BC000260-1|AAH00260.1| 316|Homo sapiens aldo-keto reductase fam... 83 1e-15
AF328729-1|AAN09721.1| 316|Homo sapiens CTCL tumor antigen HD-C... 83 1e-15
AF032455-1|AAB88851.1| 316|Homo sapiens aldose reductase protein. 83 1e-15
AB209796-1|BAD93033.1| 260|Homo sapiens aldo-keto reductase fam... 83 1e-15
AB040821-1|BAC54566.1| 263|Homo sapiens aldo-keto reductase rel... 76 1e-15
AB040820-1|BAC54565.1| 250|Homo sapiens aldo-keto reductase rel... 76 1e-15
U37100-1|AAC17469.1| 316|Homo sapiens aldose reductase-like pep... 79 2e-14
CR541801-1|CAG46600.1| 316|Homo sapiens AKR1B10 protein. 79 2e-14
BT006794-1|AAP35440.1| 316|Homo sapiens aldo-keto reductase fam... 79 2e-14
BC008837-1|AAH08837.1| 316|Homo sapiens aldo-keto reductase fam... 79 2e-14
AF149416-1|AAF07272.2| 323|Homo sapiens 3-alpha hydroxysteroid ... 79 2e-14
AF052577-1|AAC36465.1| 316|Homo sapiens aldo-keto reductase pro... 79 2e-14
U05598-1|AAA20937.1| 323|Homo sapiens dihydrodiol dehydrogenase... 78 3e-14
BT006653-1|AAP35299.1| 323|Homo sapiens aldo-keto reductase fam... 78 3e-14
BC063574-1|AAH63574.1| 323|Homo sapiens aldo-keto reductase fam... 78 3e-14
BC007024-1|AAH07024.1| 323|Homo sapiens aldo-keto reductase fam... 78 3e-14
AL713867-1|CAI16408.1| 323|Homo sapiens aldo-keto reductase fam... 78 3e-14
AL391427-1|CAI14726.1| 323|Homo sapiens aldo-keto reductase fam... 78 3e-14
AB209017-1|BAD92254.1| 286|Homo sapiens aldo-keto reductase fam... 78 3e-14
AB032153-1|BAA92891.1| 323|Homo sapiens bile acid-binding prote... 78 3e-14
AB031084-1|BAA92884.1| 323|Homo sapiens bile acid-binding prote... 78 3e-14
AB021654-1|BAA36169.1| 323|Homo sapiens DD2/bile acid-binding p... 78 3e-14
J04794-1|AAA51711.1| 325|Homo sapiens ALDR1 protein. 77 5e-14
D17793-1|BAA04619.2| 325|Homo sapiens KIAA0119 protein. 77 5e-14
CR457010-1|CAG33291.1| 325|Homo sapiens AKR1A1 protein. 77 5e-14
BT007286-1|AAP35950.1| 323|Homo sapiens aldo-keto reductase fam... 77 5e-14
BT007003-1|AAP35649.1| 325|Homo sapiens aldo-keto reductase fam... 77 5e-14
BC019230-1|AAH19230.1| 323|Homo sapiens aldo-keto reductase fam... 77 5e-14
BC005394-1|AAH05394.1| 325|Homo sapiens aldo-keto reductase fam... 77 5e-14
BC001479-1|AAH01479.1| 323|Homo sapiens aldo-keto reductase fam... 77 5e-14
BC000670-1|AAH00670.1| 325|Homo sapiens aldo-keto reductase fam... 77 5e-14
AL391427-4|CAI14729.1| 323|Homo sapiens aldo-keto reductase fam... 77 5e-14
AL355480-3|CAI22459.1| 325|Homo sapiens aldo-keto reductase fam... 77 5e-14
AF112485-1|AAF01260.1| 325|Homo sapiens aldehyde reductase prot... 77 5e-14
AF036683-1|AAB92369.1| 325|Homo sapiens aldehyde reductase prot... 77 5e-14
AB032157-1|BAA92892.1| 323|Homo sapiens prostaglandin F synthas... 77 5e-14
AB018580-1|BAA88488.1| 323|Homo sapiens hluPGFS protein. 77 5e-14
U05861-1|AAA18115.1| 323|Homo sapiens hepatic dihydrodiol dehyd... 77 6e-14
U05684-1|AAA16227.1| 323|Homo sapiens dihydrodiol dehydrogenase... 77 6e-14
M86609-1|AAB02880.1| 323|Homo sapiens dihydrodiol dehydrogenase... 77 6e-14
D26124-1|BAA05121.1| 306|Homo sapiens dihydrodiol dehydrogenase... 77 6e-14
BT007197-1|AAP35861.1| 323|Homo sapiens aldo-keto reductase fam... 77 6e-14
BC040210-1|AAH40210.1| 323|Homo sapiens aldo-keto reductase fam... 77 6e-14
BC020216-1|AAH20216.1| 323|Homo sapiens aldo-keto reductase fam... 77 6e-14
BC015490-1|AAH15490.1| 323|Homo sapiens aldo-keto reductase fam... 77 6e-14
BC005387-1|AAH05387.1| 316|Homo sapiens aldo-keto reductase fam... 77 6e-14
AL713867-3|CAI16410.1| 247|Homo sapiens aldo-keto reductase fam... 77 6e-14
AL713867-2|CAI16409.1| 323|Homo sapiens aldo-keto reductase fam... 77 6e-14
AB032150-1|BAA92886.1| 323|Homo sapiens 20 alph-hydroxysteroid ... 77 6e-14
AB031083-1|BAA92883.1| 323|Homo sapiens 20 alpha-hydroxysteroid... 77 6e-14
AB040822-1|BAC54567.1| 222|Homo sapiens aldo-keto reductase rel... 76 6e-14
S68330-1|AAD14013.1| 323|Homo sapiens chlordecone reductase hom... 76 1e-13
AF524864-1|AAO13380.1| 316|Homo sapiens aldo-ketoreductase prot... 76 1e-13
S68288-1|AAD14011.1| 323|Homo sapiens chlordecone reductase hom... 75 2e-13
L43839-1|AAB41916.1| 323|Homo sapiens 3-alpha-hydroxysteroid de... 75 3e-13
L32592-1|AAB38486.1| 323|Homo sapiens dihydrodiol dehydrogenase... 75 3e-13
S68290-1|AAD14012.1| 320|Homo sapiens chlordecone reductase hom... 74 4e-13
DQ269985-1|ABB76132.1| 323|Homo sapiens type II 3a-hydroxystero... 74 4e-13
S68287-1|AAD14010.1| 323|Homo sapiens chlordecone reductase pro... 73 1e-12
M33375-1|AAA35658.1| 308|Homo sapiens protein ( Human chlordeco... 73 1e-12
D26125-1|BAA05122.1| 321|Homo sapiens 3 alpha-hydroxysteroid/di... 73 1e-12
AL355303-2|CAI14202.1| 323|Homo sapiens aldo-keto reductase fam... 73 1e-12
AB045829-1|BAA99542.1| 323|Homo sapiens 3alpha-hydroxysteroid d... 73 1e-12
AB032163-1|BAA92893.1| 323|Homo sapiens dihydrodiol dehydrogena... 73 1e-12
AB031085-1|BAA92885.1| 323|Homo sapiens dihydrodiol dehydrogena... 73 1e-12
BC020744-1|AAH20744.1| 323|Homo sapiens aldo-keto reductase fam... 73 1e-12
AL355480-2|CAI22458.1| 147|Homo sapiens aldo-keto reductase fam... 69 2e-11
AB037902-1|BAA92887.1| 130|Homo sapiens truncated aldo-keto red... 67 5e-11
BC101205-1|AAI01206.1| 129|Homo sapiens aldo-keto reductase fam... 64 6e-10
BC101204-1|AAI01205.1| 129|Homo sapiens aldo-keto reductase fam... 64 6e-10
AL391427-2|CAI14727.1| 302|Homo sapiens aldo-keto reductase fam... 64 6e-10
AL355303-1|CAI14201.1| 302|Homo sapiens aldo-keto reductase fam... 64 6e-10
AK131335-1|BAD18494.1| 129|Homo sapiens protein ( Homo sapiens ... 64 6e-10
Z28339-1|CAA82193.1| 326|Homo sapiens delta 4-3-oxosteroid 5 be... 62 2e-09
BC130627-1|AAI30628.1| 326|Homo sapiens aldo-keto reductase fam... 62 2e-09
BC130625-1|AAI30626.1| 326|Homo sapiens aldo-keto reductase fam... 62 2e-09
AF283659-1|AAG39381.1| 326|Homo sapiens 5-beta steroid reductas... 62 2e-09
AB037905-2|BAA92890.1| 45|Homo sapiens truncated aldo-keto red... 40 0.009
AK058142-1|BAB71682.1| 146|Homo sapiens protein ( Homo sapiens ... 39 0.020
AB028065-1|BAA88489.1| 67|Homo sapiens prostaglandin F synthas... 36 0.11
AK125347-1|BAC86140.1| 277|Homo sapiens protein ( Homo sapiens ... 31 4.0
>AF263242-1|AAK58523.1| 320|Homo sapiens aldo-keto reductase
loopADR protein.
Length = 320
Score = 76.2 bits (179), Expect(2) = 2e-17
Identities = 31/57 (54%), Positives = 44/57 (77%)
Frame = +3
Query: 261 VKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIG 431
++ K++EG V+RED+FI TKLW T H+++ V A SLK L L+Y+DLYL+HWP+G
Sbjct: 50 IRCKIKEGAVRREDLFIATKLWCTCHKKSLVETACRKSLKALKLNYLDLYLIHWPMG 106
Score = 39.9 bits (89), Expect = 0.009
Identities = 20/53 (37%), Positives = 30/53 (56%)
Frame = +1
Query: 97 MPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEIG 255
+PA+GL ++ K+ ++ + V AID GYRHFD A Y E+E+G
Sbjct: 4 IPAVGLSSW---------KASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVG 47
Score = 38.7 bits (86), Expect = 0.020
Identities = 22/37 (59%), Positives = 26/37 (70%), Gaps = 2/37 (5%)
Frame = +2
Query: 506 GIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
G+VK IG+SNFN +QLER+L K G KP QIE H
Sbjct: 162 GLVKNIGVSNFNHEQLERLLNKPGLRFKPLTNQIECH 198
Score = 33.1 bits (72), Expect(2) = 2e-17
Identities = 21/79 (26%), Positives = 30/79 (37%), Gaps = 2/79 (2%)
Frame = +3
Query: 453 SDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSNLMLFK*RVTSKTF--Q 626
SD DF++TW +ED G +K K ++ + Q
Sbjct: 144 SDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLRFKPLTNQIECHPYLTQ 203
Query: 627 KEMVEFCQSESVVVMGYSP 683
K ++ FCQS V V Y P
Sbjct: 204 KNLISFCQSRDVSVTAYRP 222
>BC002862-1|AAH02862.1| 307|Homo sapiens AKR1CL2 protein protein.
Length = 307
Score = 76.2 bits (179), Expect(2) = 2e-17
Identities = 31/57 (54%), Positives = 44/57 (77%)
Frame = +3
Query: 261 VKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIG 431
++ K++EG V+RED+FI TKLW T H+++ V A SLK L L+Y+DLYL+HWP+G
Sbjct: 50 IRCKIKEGAVRREDLFIATKLWCTCHKKSLVETACRKSLKALKLNYLDLYLIHWPMG 106
Score = 39.9 bits (89), Expect = 0.009
Identities = 20/53 (37%), Positives = 30/53 (56%)
Frame = +1
Query: 97 MPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEIG 255
+PA+GL ++ K+ ++ + V AID GYRHFD A Y E+E+G
Sbjct: 4 IPAVGLSSW---------KASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVG 47
Score = 38.7 bits (86), Expect = 0.020
Identities = 22/37 (59%), Positives = 26/37 (70%), Gaps = 2/37 (5%)
Frame = +2
Query: 506 GIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
G+VK IG+SNFN +QLER+L K G KP QIE H
Sbjct: 162 GLVKNIGVSNFNHEQLERLLNKPGLRFKPLTNQIECH 198
Score = 33.1 bits (72), Expect(2) = 2e-17
Identities = 21/79 (26%), Positives = 30/79 (37%), Gaps = 2/79 (2%)
Frame = +3
Query: 453 SDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSNLMLFK*RVTSKTF--Q 626
SD DF++TW +ED G +K K ++ + Q
Sbjct: 144 SDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLRFKPLTNQIECHPYLTQ 203
Query: 627 KEMVEFCQSESVVVMGYSP 683
K ++ FCQS V V Y P
Sbjct: 204 KNLISFCQSRDVSVTAYRP 222
>AB055603-1|BAC54568.1| 307|Homo sapiens aldo-keto reductase
related protein 4 protein.
Length = 307
Score = 76.2 bits (179), Expect(2) = 2e-17
Identities = 31/57 (54%), Positives = 44/57 (77%)
Frame = +3
Query: 261 VKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIG 431
++ K++EG V+RED+FI TKLW T H+++ V A SLK L L+Y+DLYL+HWP+G
Sbjct: 50 IRCKIKEGAVRREDLFIATKLWCTCHKKSLVETACRKSLKALKLNYLDLYLIHWPMG 106
Score = 39.9 bits (89), Expect = 0.009
Identities = 20/53 (37%), Positives = 30/53 (56%)
Frame = +1
Query: 97 MPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEIG 255
+PA+GL ++ K+ ++ + V AID GYRHFD A Y E+E+G
Sbjct: 4 IPAVGLSSW---------KASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVG 47
Score = 38.7 bits (86), Expect = 0.020
Identities = 22/37 (59%), Positives = 26/37 (70%), Gaps = 2/37 (5%)
Frame = +2
Query: 506 GIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
G+VK IG+SNFN +QLER+L K G KP QIE H
Sbjct: 162 GLVKNIGVSNFNHEQLERLLNKPGLRFKPLTNQIECH 198
Score = 33.1 bits (72), Expect(2) = 2e-17
Identities = 21/79 (26%), Positives = 30/79 (37%), Gaps = 2/79 (2%)
Frame = +3
Query: 453 SDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSNLMLFK*RVTSKTF--Q 626
SD DF++TW +ED G +K K ++ + Q
Sbjct: 144 SDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLRFKPLTNQIECHPYLTQ 203
Query: 627 KEMVEFCQSESVVVMGYSP 683
K ++ FCQS V V Y P
Sbjct: 204 KNLISFCQSRDVSVTAYRP 222
>CR542203-1|CAG47000.1| 316|Homo sapiens AKR1B1 protein.
Length = 316
Score = 84.6 bits (200), Expect = 3e-16
Identities = 51/162 (31%), Positives = 80/162 (49%), Gaps = 13/162 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ E VVKRE++FI +KLW T H + V A +L L LDY+DLYL+HWPIG
Sbjct: 58 AIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPIGFK 117
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
+ + SD + ++TW +E+ G +KA K
Sbjct: 118 PGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLK 177
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYSPFRFPGXP 704
++ + Q++++++CQS+ +VV YSP P P
Sbjct: 178 YKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRP 219
Score = 54.4 bits (125), Expect = 4e-07
Identities = 29/61 (47%), Positives = 36/61 (59%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
L +NNG MP +GLGT+ KS Q+ + V AIDVGYRH D A VY+ E E+
Sbjct: 5 LLLNNGAKMPILGLGTW---------KSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEV 55
Query: 253 G 255
G
Sbjct: 56 G 56
Score = 35.1 bits (77), Expect = 0.25
Identities = 20/37 (54%), Positives = 24/37 (64%), Gaps = 2/37 (5%)
Frame = +2
Query: 506 GIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
G+VK IG+SNFN Q+E +L K G KP QIE H
Sbjct: 152 GLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECH 188
>X15414-1|CAA33460.1| 316|Homo sapiens protein ( Human mRNA for
aldose reductase (EC 1.1.1.2). ).
Length = 316
Score = 82.6 bits (195), Expect = 1e-15
Identities = 50/162 (30%), Positives = 79/162 (48%), Gaps = 13/162 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ E VVKRE++FI +KLW T H + V A +L L LDY+DLYL+HWP G
Sbjct: 58 AIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFK 117
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
+ + SD + ++TW +E+ G +KA K
Sbjct: 118 PGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLK 177
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYSPFRFPGXP 704
++ + Q++++++CQS+ +VV YSP P P
Sbjct: 178 YKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRP 219
Score = 54.4 bits (125), Expect = 4e-07
Identities = 29/61 (47%), Positives = 36/61 (59%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
L +NNG MP +GLGT+ KS Q+ + V AIDVGYRH D A VY+ E E+
Sbjct: 5 LLLNNGAKMPILGLGTW---------KSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEV 55
Query: 253 G 255
G
Sbjct: 56 G 56
Score = 35.1 bits (77), Expect = 0.25
Identities = 20/37 (54%), Positives = 24/37 (64%), Gaps = 2/37 (5%)
Frame = +2
Query: 506 GIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
G+VK IG+SNFN Q+E +L K G KP QIE H
Sbjct: 152 GLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECH 188
>M59783-1|AAA51712.1| 316|Homo sapiens aldose reductase protein.
Length = 316
Score = 82.6 bits (195), Expect = 1e-15
Identities = 50/162 (30%), Positives = 79/162 (48%), Gaps = 13/162 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ E VVKRE++FI +KLW T H + V A +L L LDY+DLYL+HWP G
Sbjct: 58 AIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFK 117
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
+ + SD + ++TW +E+ G +KA K
Sbjct: 118 PGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLK 177
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYSPFRFPGXP 704
++ + Q++++++CQS+ +VV YSP P P
Sbjct: 178 YKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRP 219
Score = 54.4 bits (125), Expect = 4e-07
Identities = 29/61 (47%), Positives = 36/61 (59%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
L +NNG MP +GLGT+ KS Q+ + V AIDVGYRH D A VY+ E E+
Sbjct: 5 LLLNNGAKMPILGLGTW---------KSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEV 55
Query: 253 G 255
G
Sbjct: 56 G 56
Score = 35.1 bits (77), Expect = 0.25
Identities = 20/37 (54%), Positives = 24/37 (64%), Gaps = 2/37 (5%)
Frame = +2
Query: 506 GIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
G+VK IG+SNFN Q+E +L K G KP QIE H
Sbjct: 152 GLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECH 188
>M34720-1|AAA35560.1| 316|Homo sapiens protein ( Human aldose
reductase mRNA, complete cds. ).
Length = 316
Score = 82.6 bits (195), Expect = 1e-15
Identities = 50/162 (30%), Positives = 79/162 (48%), Gaps = 13/162 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ E VVKRE++FI +KLW T H + V A +L L LDY+DLYL+HWP G
Sbjct: 58 AIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFK 117
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
+ + SD + ++TW +E+ G +KA K
Sbjct: 118 PGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLK 177
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYSPFRFPGXP 704
++ + Q++++++CQS+ +VV YSP P P
Sbjct: 178 YKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRP 219
Score = 54.4 bits (125), Expect = 4e-07
Identities = 29/61 (47%), Positives = 36/61 (59%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
L +NNG MP +GLGT+ KS Q+ + V AIDVGYRH D A VY+ E E+
Sbjct: 5 LLLNNGAKMPILGLGTW---------KSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEV 55
Query: 253 G 255
G
Sbjct: 56 G 56
Score = 35.1 bits (77), Expect = 0.25
Identities = 20/37 (54%), Positives = 24/37 (64%), Gaps = 2/37 (5%)
Frame = +2
Query: 506 GIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
G+VK IG+SNFN Q+E +L K G KP QIE H
Sbjct: 152 GLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECH 188
>J05474-1|AAA51715.1| 316|Homo sapiens aldose reductase protein.
Length = 316
Score = 82.6 bits (195), Expect = 1e-15
Identities = 50/162 (30%), Positives = 79/162 (48%), Gaps = 13/162 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ E VVKRE++FI +KLW T H + V A +L L LDY+DLYL+HWP G
Sbjct: 58 AIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFK 117
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
+ + SD + ++TW +E+ G +KA K
Sbjct: 118 PGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLK 177
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYSPFRFPGXP 704
++ + Q++++++CQS+ +VV YSP P P
Sbjct: 178 YKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRP 219
Score = 54.4 bits (125), Expect = 4e-07
Identities = 29/61 (47%), Positives = 36/61 (59%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
L +NNG MP +GLGT+ KS Q+ + V AIDVGYRH D A VY+ E E+
Sbjct: 5 LLLNNGAKMPILGLGTW---------KSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEV 55
Query: 253 G 255
G
Sbjct: 56 G 56
Score = 35.1 bits (77), Expect = 0.25
Identities = 20/37 (54%), Positives = 24/37 (64%), Gaps = 2/37 (5%)
Frame = +2
Query: 506 GIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
G+VK IG+SNFN Q+E +L K G KP QIE H
Sbjct: 152 GLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECH 188
>J05017-1|AAA51714.1| 316|Homo sapiens ALDR1 protein.
Length = 316
Score = 82.6 bits (195), Expect = 1e-15
Identities = 50/162 (30%), Positives = 79/162 (48%), Gaps = 13/162 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ E VVKRE++FI +KLW T H + V A +L L LDY+DLYL+HWP G
Sbjct: 58 AIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFK 117
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
+ + SD + ++TW +E+ G +KA K
Sbjct: 118 PGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLK 177
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYSPFRFPGXP 704
++ + Q++++++CQS+ +VV YSP P P
Sbjct: 178 YKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRP 219
Score = 53.6 bits (123), Expect = 7e-07
Identities = 28/59 (47%), Positives = 35/59 (59%)
Frame = +1
Query: 79 MNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEIG 255
+NNG MP +GLGT+ KS Q+ + V AIDVGYRH D A VY+ E E+G
Sbjct: 7 LNNGAKMPILGLGTW---------KSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVG 56
Score = 35.1 bits (77), Expect = 0.25
Identities = 20/37 (54%), Positives = 24/37 (64%), Gaps = 2/37 (5%)
Frame = +2
Query: 506 GIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
G+VK IG+SNFN Q+E +L K G KP QIE H
Sbjct: 152 GLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECH 188
>J04795-1|AAA51713.1| 316|Homo sapiens ALDR1 protein.
Length = 316
Score = 82.6 bits (195), Expect = 1e-15
Identities = 50/162 (30%), Positives = 79/162 (48%), Gaps = 13/162 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ E VVKRE++FI +KLW T H + V A +L L LDY+DLYL+HWP G
Sbjct: 58 AIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFK 117
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
+ + SD + ++TW +E+ G +KA K
Sbjct: 118 PGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLK 177
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYSPFRFPGXP 704
++ + Q++++++CQS+ +VV YSP P P
Sbjct: 178 YKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRP 219
Score = 54.4 bits (125), Expect = 4e-07
Identities = 29/61 (47%), Positives = 36/61 (59%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
L +NNG MP +GLGT+ KS Q+ + V AIDVGYRH D A VY+ E E+
Sbjct: 5 LLLNNGAKMPILGLGTW---------KSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEV 55
Query: 253 G 255
G
Sbjct: 56 G 56
Score = 35.1 bits (77), Expect = 0.25
Identities = 20/37 (54%), Positives = 24/37 (64%), Gaps = 2/37 (5%)
Frame = +2
Query: 506 GIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
G+VK IG+SNFN Q+E +L K G KP QIE H
Sbjct: 152 GLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECH 188
>CR450351-1|CAG29347.1| 316|Homo sapiens AKR1B1 protein.
Length = 316
Score = 82.6 bits (195), Expect = 1e-15
Identities = 50/162 (30%), Positives = 79/162 (48%), Gaps = 13/162 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ E VVKRE++FI +KLW T H + V A +L L LDY+DLYL+HWP G
Sbjct: 58 AIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFR 117
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
+ + SD + ++TW +E+ G +KA K
Sbjct: 118 PGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILSKPGLK 177
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYSPFRFPGXP 704
++ + Q++++++CQS+ +VV YSP P P
Sbjct: 178 YKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRP 219
Score = 54.4 bits (125), Expect = 4e-07
Identities = 29/61 (47%), Positives = 36/61 (59%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
L +NNG MP +GLGT+ KS Q+ + V AIDVGYRH D A VY+ E E+
Sbjct: 5 LLLNNGAKMPILGLGTW---------KSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEV 55
Query: 253 G 255
G
Sbjct: 56 G 56
Score = 35.1 bits (77), Expect = 0.25
Identities = 20/37 (54%), Positives = 24/37 (64%), Gaps = 2/37 (5%)
Frame = +2
Query: 506 GIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
G+VK IG+SNFN Q+E +L K G KP QIE H
Sbjct: 152 GLVKAIGISNFNHLQVEMILSKPGLKYKPAVNQIECH 188
>BT019859-1|AAV38662.1| 316|Homo sapiens aldo-keto reductase family
1, member B1 (aldose reductase) protein.
Length = 316
Score = 82.6 bits (195), Expect = 1e-15
Identities = 50/162 (30%), Positives = 79/162 (48%), Gaps = 13/162 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ E VVKRE++FI +KLW T H + V A +L L LDY+DLYL+HWP G
Sbjct: 58 AIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFK 117
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
+ + SD + ++TW +E+ G +KA K
Sbjct: 118 PGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLK 177
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYSPFRFPGXP 704
++ + Q++++++CQS+ +VV YSP P P
Sbjct: 178 YKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRP 219
Score = 54.4 bits (125), Expect = 4e-07
Identities = 29/61 (47%), Positives = 36/61 (59%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
L +NNG MP +GLGT+ KS Q+ + V AIDVGYRH D A VY+ E E+
Sbjct: 5 LLLNNGAKMPILGLGTW---------KSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEV 55
Query: 253 G 255
G
Sbjct: 56 G 56
Score = 35.1 bits (77), Expect = 0.25
Identities = 20/37 (54%), Positives = 24/37 (64%), Gaps = 2/37 (5%)
Frame = +2
Query: 506 GIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
G+VK IG+SNFN Q+E +L K G KP QIE H
Sbjct: 152 GLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECH 188
>BC010391-1|AAH10391.1| 316|Homo sapiens aldo-keto reductase family
1, member B1 (aldose reductase) protein.
Length = 316
Score = 82.6 bits (195), Expect = 1e-15
Identities = 50/162 (30%), Positives = 79/162 (48%), Gaps = 13/162 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ E VVKRE++FI +KLW T H + V A +L L LDY+DLYL+HWP G
Sbjct: 58 AIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFK 117
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
+ + SD + ++TW +E+ G +KA K
Sbjct: 118 PGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLK 177
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYSPFRFPGXP 704
++ + Q++++++CQS+ +VV YSP P P
Sbjct: 178 YKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRP 219
Score = 54.4 bits (125), Expect = 4e-07
Identities = 29/61 (47%), Positives = 36/61 (59%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
L +NNG MP +GLGT+ KS Q+ + V AIDVGYRH D A VY+ E E+
Sbjct: 5 LLLNNGAKMPILGLGTW---------KSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEV 55
Query: 253 G 255
G
Sbjct: 56 G 56
Score = 35.1 bits (77), Expect = 0.25
Identities = 20/37 (54%), Positives = 24/37 (64%), Gaps = 2/37 (5%)
Frame = +2
Query: 506 GIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
G+VK IG+SNFN Q+E +L K G KP QIE H
Sbjct: 152 GLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECH 188
>BC000260-1|AAH00260.1| 316|Homo sapiens aldo-keto reductase family
1, member B1 (aldose reductase) protein.
Length = 316
Score = 82.6 bits (195), Expect = 1e-15
Identities = 50/162 (30%), Positives = 79/162 (48%), Gaps = 13/162 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ E VVKRE++FI +KLW T H + V A +L L LDY+DLYL+HWP G
Sbjct: 58 AIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFK 117
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
+ + SD + ++TW +E+ G +KA K
Sbjct: 118 PGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLK 177
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYSPFRFPGXP 704
++ + Q++++++CQS+ +VV YSP P P
Sbjct: 178 YKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRP 219
Score = 54.4 bits (125), Expect = 4e-07
Identities = 29/61 (47%), Positives = 36/61 (59%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
L +NNG MP +GLGT+ KS Q+ + V AIDVGYRH D A VY+ E E+
Sbjct: 5 LLLNNGAKMPILGLGTW---------KSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEV 55
Query: 253 G 255
G
Sbjct: 56 G 56
Score = 35.1 bits (77), Expect = 0.25
Identities = 20/37 (54%), Positives = 24/37 (64%), Gaps = 2/37 (5%)
Frame = +2
Query: 506 GIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
G+VK IG+SNFN Q+E +L K G KP QIE H
Sbjct: 152 GLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECH 188
>AF328729-1|AAN09721.1| 316|Homo sapiens CTCL tumor antigen
HD-CL-07 protein.
Length = 316
Score = 82.6 bits (195), Expect = 1e-15
Identities = 50/162 (30%), Positives = 79/162 (48%), Gaps = 13/162 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ E VVKRE++FI +KLW T H + V A +L L LDY+DLYL+HWP G
Sbjct: 58 AIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFK 117
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
+ + SD + ++TW +E+ G +KA K
Sbjct: 118 PGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLK 177
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYSPFRFPGXP 704
++ + Q++++++CQS+ +VV YSP P P
Sbjct: 178 YKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRP 219
Score = 54.4 bits (125), Expect = 4e-07
Identities = 29/61 (47%), Positives = 36/61 (59%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
L +NNG MP +GLGT+ KS Q+ + V AIDVGYRH D A VY+ E E+
Sbjct: 5 LLLNNGAKMPILGLGTW---------KSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEV 55
Query: 253 G 255
G
Sbjct: 56 G 56
Score = 35.1 bits (77), Expect = 0.25
Identities = 20/37 (54%), Positives = 24/37 (64%), Gaps = 2/37 (5%)
Frame = +2
Query: 506 GIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
G+VK IG+SNFN Q+E +L K G KP QIE H
Sbjct: 152 GLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECH 188
>AF032455-1|AAB88851.1| 316|Homo sapiens aldose reductase protein.
Length = 316
Score = 82.6 bits (195), Expect = 1e-15
Identities = 50/162 (30%), Positives = 79/162 (48%), Gaps = 13/162 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ E VVKRE++FI +KLW T H + V A +L L LDY+DLYL+HWP G
Sbjct: 58 AIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFK 117
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
+ + SD + ++TW +E+ G +KA K
Sbjct: 118 PGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLK 177
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYSPFRFPGXP 704
++ + Q++++++CQS+ +VV YSP P P
Sbjct: 178 YKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRP 219
Score = 54.4 bits (125), Expect = 4e-07
Identities = 29/61 (47%), Positives = 36/61 (59%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
L +NNG MP +GLGT+ KS Q+ + V AIDVGYRH D A VY+ E E+
Sbjct: 5 LLLNNGAKMPILGLGTW---------KSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEV 55
Query: 253 G 255
G
Sbjct: 56 G 56
Score = 35.1 bits (77), Expect = 0.25
Identities = 20/37 (54%), Positives = 24/37 (64%), Gaps = 2/37 (5%)
Frame = +2
Query: 506 GIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
G+VK IG+SNFN Q+E +L K G KP QIE H
Sbjct: 152 GLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECH 188
>AB209796-1|BAD93033.1| 260|Homo sapiens aldo-keto reductase family
1, member B1 variant protein.
Length = 260
Score = 82.6 bits (195), Expect = 1e-15
Identities = 50/162 (30%), Positives = 79/162 (48%), Gaps = 13/162 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ E VVKRE++FI +KLW T H + V A +L L LDY+DLYL+HWP G
Sbjct: 55 AIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFK 114
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
+ + SD + ++TW +E+ G +KA K
Sbjct: 115 PGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLK 174
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYSPFRFPGXP 704
++ + Q++++++CQS+ +VV YSP P P
Sbjct: 175 YKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRP 216
Score = 54.4 bits (125), Expect = 4e-07
Identities = 29/61 (47%), Positives = 36/61 (59%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
L +NNG MP +GLGT+ KS Q+ + V AIDVGYRH D A VY+ E E+
Sbjct: 2 LLLNNGAKMPILGLGTW---------KSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEV 52
Query: 253 G 255
G
Sbjct: 53 G 53
Score = 35.1 bits (77), Expect = 0.25
Identities = 20/37 (54%), Positives = 24/37 (64%), Gaps = 2/37 (5%)
Frame = +2
Query: 506 GIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
G+VK IG+SNFN Q+E +L K G KP QIE H
Sbjct: 149 GLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECH 185
>AB040821-1|BAC54566.1| 263|Homo sapiens aldo-keto reductase
related protein 2 protein.
Length = 263
Score = 76.2 bits (179), Expect(2) = 1e-15
Identities = 31/57 (54%), Positives = 44/57 (77%)
Frame = +3
Query: 261 VKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIG 431
++ K++EG V+RED+FI TKLW T H+++ V A SLK L L+Y+DLYL+HWP+G
Sbjct: 50 IRCKIKEGAVRREDLFIATKLWCTCHKKSLVETACRKSLKALKLNYLDLYLIHWPMG 106
Score = 39.9 bits (89), Expect = 0.009
Identities = 20/53 (37%), Positives = 30/53 (56%)
Frame = +1
Query: 97 MPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEIG 255
+PA+GL ++ K+ ++ + V AID GYRHFD A Y E+E+G
Sbjct: 4 IPAVGLSSW---------KASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVG 47
Score = 34.7 bits (76), Expect = 0.33
Identities = 14/22 (63%), Positives = 19/22 (86%)
Frame = +2
Query: 506 GIVKGIGLSNFNKQQLERVLKE 571
G+VK IG+SNFN +QLER+L +
Sbjct: 162 GLVKNIGVSNFNHEQLERLLNK 183
Score = 26.6 bits (56), Expect(2) = 1e-15
Identities = 10/22 (45%), Positives = 14/22 (63%)
Frame = +3
Query: 453 SDVDFMETWRGLEDAQRMG*LK 518
SD DF++TW +ED G +K
Sbjct: 144 SDTDFLDTWEAMEDLVITGLVK 165
>AB040820-1|BAC54565.1| 250|Homo sapiens aldo-keto reductase
related protein 1 protein.
Length = 250
Score = 76.2 bits (179), Expect(2) = 1e-15
Identities = 31/57 (54%), Positives = 44/57 (77%)
Frame = +3
Query: 261 VKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIG 431
++ K++EG V+RED+FI TKLW T H+++ V A SLK L L+Y+DLYL+HWP+G
Sbjct: 50 IRCKIKEGAVRREDLFIATKLWCTCHKKSLVETACRKSLKALKLNYLDLYLIHWPMG 106
Score = 39.9 bits (89), Expect = 0.009
Identities = 20/53 (37%), Positives = 30/53 (56%)
Frame = +1
Query: 97 MPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEIG 255
+PA+GL ++ K+ ++ + V AID GYRHFD A Y E+E+G
Sbjct: 4 IPAVGLSSW---------KASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVG 47
Score = 34.7 bits (76), Expect = 0.33
Identities = 14/22 (63%), Positives = 19/22 (86%)
Frame = +2
Query: 506 GIVKGIGLSNFNKQQLERVLKE 571
G+VK IG+SNFN +QLER+L +
Sbjct: 162 GLVKNIGVSNFNHEQLERLLNK 183
Score = 26.6 bits (56), Expect(2) = 1e-15
Identities = 10/22 (45%), Positives = 14/22 (63%)
Frame = +3
Query: 453 SDVDFMETWRGLEDAQRMG*LK 518
SD DF++TW +ED G +K
Sbjct: 144 SDTDFLDTWEAMEDLVITGLVK 165
>U37100-1|AAC17469.1| 316|Homo sapiens aldose reductase-like
peptide protein.
Length = 316
Score = 78.6 bits (185), Expect = 2e-14
Identities = 54/167 (32%), Positives = 85/167 (50%), Gaps = 17/167 (10%)
Frame = +3
Query: 255 EAVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL 434
EA++ K++E VKRED+FI +KLW T R V +A +LK L L Y+D+YL+HWP G
Sbjct: 57 EAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGF 116
Query: 435 NA--DYSHSD---------VDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALS 581
+ D D F++ W +E+ G +KA S S ++ +K L+
Sbjct: 117 KSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALG--VSNFSHFQ--IEKLLN 172
Query: 582 NLMLFK*RVTSKT------FQKEMVEFCQSESVVVMGYSPFRFPGXP 704
L VT++ Q++++++C S+ + V YSP P P
Sbjct: 173 KPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRP 219
Score = 44.0 bits (99), Expect = 5e-04
Identities = 23/62 (37%), Positives = 36/62 (58%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
++++ MP +GLGT+ KS ++++ V AID GYRH D A VY+ E E+
Sbjct: 5 VELSTKAKMPIVGLGTW---------KSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEV 55
Query: 253 GK 258
G+
Sbjct: 56 GE 57
Score = 31.5 bits (68), Expect = 3.1
Identities = 17/37 (45%), Positives = 25/37 (67%), Gaps = 2/37 (5%)
Frame = +2
Query: 506 GIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
G+VK +G+SNF+ Q+E++L K G KP Q+E H
Sbjct: 152 GLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECH 188
>CR541801-1|CAG46600.1| 316|Homo sapiens AKR1B10 protein.
Length = 316
Score = 78.6 bits (185), Expect = 2e-14
Identities = 54/167 (32%), Positives = 85/167 (50%), Gaps = 17/167 (10%)
Frame = +3
Query: 255 EAVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL 434
EA++ K++E VKRED+FI +KLW T R V +A +LK L L Y+D+YL+HWP G
Sbjct: 57 EAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGF 116
Query: 435 NA--DYSHSD---------VDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALS 581
+ D D F++ W +E+ G +KA S S ++ +K L+
Sbjct: 117 KSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALG--VSNFSHFQ--IEKLLN 172
Query: 582 NLMLFK*RVTSKT------FQKEMVEFCQSESVVVMGYSPFRFPGXP 704
L VT++ Q++++++C S+ + V YSP P P
Sbjct: 173 KPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRP 219
Score = 44.0 bits (99), Expect = 5e-04
Identities = 23/62 (37%), Positives = 36/62 (58%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
++++ MP +GLGT+ KS ++++ V AID GYRH D A VY+ E E+
Sbjct: 5 VELSTKAKMPIVGLGTW---------KSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEV 55
Query: 253 GK 258
G+
Sbjct: 56 GE 57
Score = 31.5 bits (68), Expect = 3.1
Identities = 17/37 (45%), Positives = 25/37 (67%), Gaps = 2/37 (5%)
Frame = +2
Query: 506 GIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
G+VK +G+SNF+ Q+E++L K G KP Q+E H
Sbjct: 152 GLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECH 188
>BT006794-1|AAP35440.1| 316|Homo sapiens aldo-keto reductase family
1, member B10 (aldose reductase) protein.
Length = 316
Score = 78.6 bits (185), Expect = 2e-14
Identities = 54/167 (32%), Positives = 85/167 (50%), Gaps = 17/167 (10%)
Frame = +3
Query: 255 EAVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL 434
EA++ K++E VKRED+FI +KLW T R V +A +LK L L Y+D+YL+HWP G
Sbjct: 57 EAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGF 116
Query: 435 NA--DYSHSD---------VDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALS 581
+ D D F++ W +E+ G +KA S S ++ +K L+
Sbjct: 117 KSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALG--VSNFSHFQ--IEKLLN 172
Query: 582 NLMLFK*RVTSKT------FQKEMVEFCQSESVVVMGYSPFRFPGXP 704
L VT++ Q++++++C S+ + V YSP P P
Sbjct: 173 KPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRP 219
Score = 44.0 bits (99), Expect = 5e-04
Identities = 23/62 (37%), Positives = 36/62 (58%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
++++ MP +GLGT+ KS ++++ V AID GYRH D A VY+ E E+
Sbjct: 5 VELSTKAKMPIVGLGTW---------KSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEV 55
Query: 253 GK 258
G+
Sbjct: 56 GE 57
Score = 31.5 bits (68), Expect = 3.1
Identities = 17/37 (45%), Positives = 25/37 (67%), Gaps = 2/37 (5%)
Frame = +2
Query: 506 GIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
G+VK +G+SNF+ Q+E++L K G KP Q+E H
Sbjct: 152 GLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECH 188
>BC008837-1|AAH08837.1| 316|Homo sapiens aldo-keto reductase family
1, member B10 (aldose reductase) protein.
Length = 316
Score = 78.6 bits (185), Expect = 2e-14
Identities = 54/167 (32%), Positives = 85/167 (50%), Gaps = 17/167 (10%)
Frame = +3
Query: 255 EAVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL 434
EA++ K++E VKRED+FI +KLW T R V +A +LK L L Y+D+YL+HWP G
Sbjct: 57 EAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGF 116
Query: 435 NA--DYSHSD---------VDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALS 581
+ D D F++ W +E+ G +KA S S ++ +K L+
Sbjct: 117 KSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALG--VSNFSHFQ--IEKLLN 172
Query: 582 NLMLFK*RVTSKT------FQKEMVEFCQSESVVVMGYSPFRFPGXP 704
L VT++ Q++++++C S+ + V YSP P P
Sbjct: 173 KPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRP 219
Score = 44.0 bits (99), Expect = 5e-04
Identities = 23/62 (37%), Positives = 36/62 (58%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
++++ MP +GLGT+ KS ++++ V AID GYRH D A VY+ E E+
Sbjct: 5 VELSTKAKMPIVGLGTW---------KSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEV 55
Query: 253 GK 258
G+
Sbjct: 56 GE 57
Score = 31.5 bits (68), Expect = 3.1
Identities = 17/37 (45%), Positives = 25/37 (67%), Gaps = 2/37 (5%)
Frame = +2
Query: 506 GIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
G+VK +G+SNF+ Q+E++L K G KP Q+E H
Sbjct: 152 GLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECH 188
>AF149416-1|AAF07272.2| 323|Homo sapiens 3-alpha hydroxysteroid
dehydrogenase type IIb protein.
Length = 323
Score = 78.6 bits (185), Expect = 2e-14
Identities = 50/154 (32%), Positives = 78/154 (50%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW+T HR V A+ +SLKK LDY+DLYL+H P+ L
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWSTSHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLK 123
Query: 435 -NADYSHSD---------VDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
+ S +D VD TW +E + G K+ K
Sbjct: 124 PGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + + ++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYS 217
Score = 45.2 bits (102), Expect = 2e-04
Identities = 22/61 (36%), Positives = 38/61 (62%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V +SK ++ + AI+ G+RH D+A +Y E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPPE---VPRSKALEVSKL---AIEAGFRHIDSAHLYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
Score = 38.7 bits (86), Expect = 0.020
Identities = 20/42 (47%), Positives = 27/42 (64%), Gaps = 2/42 (4%)
Frame = +2
Query: 491 RCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+C G+ K IG+SNFN++QLE +L K G KP Q+E H
Sbjct: 153 KCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECH 194
>AF052577-1|AAC36465.1| 316|Homo sapiens aldo-keto reductase
protein.
Length = 316
Score = 78.6 bits (185), Expect = 2e-14
Identities = 54/167 (32%), Positives = 85/167 (50%), Gaps = 17/167 (10%)
Frame = +3
Query: 255 EAVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL 434
EA++ K++E VKRED+FI +KLW T R V +A +LK L L Y+D+YL+HWP G
Sbjct: 57 EAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGF 116
Query: 435 NA--DYSHSD---------VDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALS 581
+ D D F++ W +E+ G +KA S S ++ +K L+
Sbjct: 117 KSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALG--VSNFSHFQ--IEKLLN 172
Query: 582 NLMLFK*RVTSKT------FQKEMVEFCQSESVVVMGYSPFRFPGXP 704
L VT++ Q++++++C S+ + V YSP P P
Sbjct: 173 KPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRP 219
Score = 44.0 bits (99), Expect = 5e-04
Identities = 23/62 (37%), Positives = 36/62 (58%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
++++ MP +GLGT+ KS ++++ V AID GYRH D A VY+ E E+
Sbjct: 5 VELSTKAKMPIVGLGTW---------KSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEV 55
Query: 253 GK 258
G+
Sbjct: 56 GE 57
Score = 31.5 bits (68), Expect = 3.1
Identities = 17/37 (45%), Positives = 25/37 (67%), Gaps = 2/37 (5%)
Frame = +2
Query: 506 GIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
G+VK +G+SNF+ Q+E++L K G KP Q+E H
Sbjct: 152 GLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECH 188
>U05598-1|AAA20937.1| 323|Homo sapiens dihydrodiol dehydrogenase
protein.
Length = 323
Score = 78.2 bits (184), Expect = 3e-14
Identities = 48/154 (31%), Positives = 75/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW+ HR V A+ SLK L LDY+DLYL+H+P+ +
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 124 PGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q+++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYS 217
Score = 47.2 bits (107), Expect = 6e-05
Identities = 24/61 (39%), Positives = 36/61 (59%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V KSK + V AI+ G+ H D+A VY E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAE---VPKSK---ALEAVKLAIEAGFHHIDSAHVYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
>BT006653-1|AAP35299.1| 323|Homo sapiens aldo-keto reductase family
1, member C2 (dihydrodiol dehydrogenase 2; bile acid
protein.
Length = 323
Score = 78.2 bits (184), Expect = 3e-14
Identities = 48/154 (31%), Positives = 75/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW+ HR V A+ SLK L LDY+DLYL+H+P+ +
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 124 PGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q+++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYS 217
Score = 47.2 bits (107), Expect = 6e-05
Identities = 24/61 (39%), Positives = 36/61 (59%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V KSK + V AI+ G+ H D+A VY E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAE---VPKSK---ALEAVKLAIEAGFHHIDSAHVYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
>BC063574-1|AAH63574.1| 323|Homo sapiens aldo-keto reductase family
1, member C2 (dihydrodiol dehydrogenase 2; bile acid
protein.
Length = 323
Score = 78.2 bits (184), Expect = 3e-14
Identities = 48/154 (31%), Positives = 75/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW+ HR V A+ SLK L LDY+DLYL+H+P+ +
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 124 PGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q+++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYS 217
Score = 47.2 bits (107), Expect = 6e-05
Identities = 24/61 (39%), Positives = 36/61 (59%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V KSK + V AI+ G+ H D+A VY E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAE---VPKSK---ALEAVKLAIEAGFHHIDSAHVYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
>BC007024-1|AAH07024.1| 323|Homo sapiens aldo-keto reductase family
1, member C2 (dihydrodiol dehydrogenase 2; bile acid
protein.
Length = 323
Score = 78.2 bits (184), Expect = 3e-14
Identities = 48/154 (31%), Positives = 75/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW+ HR V A+ SLK L LDY+DLYL+H+P+ +
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 124 PGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q+++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYS 217
Score = 47.2 bits (107), Expect = 6e-05
Identities = 24/61 (39%), Positives = 36/61 (59%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V KSK + V AI+ G+ H D+A VY E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAE---VPKSK---ALEAVKLAIEAGFHHIDSAHVYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
>AL713867-1|CAI16408.1| 323|Homo sapiens aldo-keto reductase family
1, member C2 (dihydrodiol dehydrogenase 2; bile acid
protein.
Length = 323
Score = 78.2 bits (184), Expect = 3e-14
Identities = 48/154 (31%), Positives = 75/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW+ HR V A+ SLK L LDY+DLYL+H+P+ +
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 124 PGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q+++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYS 217
Score = 47.2 bits (107), Expect = 6e-05
Identities = 24/61 (39%), Positives = 36/61 (59%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V KSK + V AI+ G+ H D+A VY E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAE---VPKSK---ALEAVKLAIEAGFHHIDSAHVYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
>AL391427-1|CAI14726.1| 323|Homo sapiens aldo-keto reductase family
1, member C2 (dihydrodiol dehydrogenase 2; bile acid
protein.
Length = 323
Score = 78.2 bits (184), Expect = 3e-14
Identities = 48/154 (31%), Positives = 75/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW+ HR V A+ SLK L LDY+DLYL+H+P+ +
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 124 PGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q+++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYS 217
Score = 47.2 bits (107), Expect = 6e-05
Identities = 24/61 (39%), Positives = 36/61 (59%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V KSK + V AI+ G+ H D+A VY E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAE---VPKSK---ALEAVKLAIEAGFHHIDSAHVYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
>AB209017-1|BAD92254.1| 286|Homo sapiens aldo-keto reductase family
1, member C2 variant protein.
Length = 286
Score = 78.2 bits (184), Expect = 3e-14
Identities = 48/154 (31%), Positives = 75/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW+ HR V A+ SLK L LDY+DLYL+H+P+ +
Sbjct: 77 AIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 136
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 137 PGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLK 196
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q+++++FC+S+ +V++ YS
Sbjct: 197 YKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYS 230
Score = 47.2 bits (107), Expect = 6e-05
Identities = 24/61 (39%), Positives = 36/61 (59%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V KSK + V AI+ G+ H D+A VY E+++
Sbjct: 21 VKLNDGHFMPVLGFGTYAPAE---VPKSK---ALEAVKLAIEAGFHHIDSAHVYNNEEQV 74
Query: 253 G 255
G
Sbjct: 75 G 75
>AB032153-1|BAA92891.1| 323|Homo sapiens bile acid-binding protein
protein.
Length = 323
Score = 78.2 bits (184), Expect = 3e-14
Identities = 48/154 (31%), Positives = 75/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW+ HR V A+ SLK L LDY+DLYL+H+P+ +
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 124 PGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q+++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYS 217
Score = 47.2 bits (107), Expect = 6e-05
Identities = 24/61 (39%), Positives = 36/61 (59%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V KSK + V AI+ G+ H D+A VY E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAE---VPKSK---ALEAVKLAIEAGFHHIDSAHVYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
>AB031084-1|BAA92884.1| 323|Homo sapiens bile acid-binding protein
protein.
Length = 323
Score = 78.2 bits (184), Expect = 3e-14
Identities = 48/154 (31%), Positives = 75/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW+ HR V A+ SLK L LDY+DLYL+H+P+ +
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 124 PGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q+++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYS 217
Score = 47.2 bits (107), Expect = 6e-05
Identities = 24/61 (39%), Positives = 36/61 (59%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V KSK + V AI+ G+ H D+A VY E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAE---VPKSK---ALEAVKLAIEAGFHHIDSAHVYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
>AB021654-1|BAA36169.1| 323|Homo sapiens DD2/bile acid-binding
protein/AKR1C2/3alpha-hydroxysteroid dehydrogenase type
3 protein.
Length = 323
Score = 78.2 bits (184), Expect = 3e-14
Identities = 48/154 (31%), Positives = 75/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW+ HR V A+ SLK L LDY+DLYL+H+P+ +
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 124 PGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q+++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYS 217
Score = 47.2 bits (107), Expect = 6e-05
Identities = 24/61 (39%), Positives = 36/61 (59%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V KSK + V AI+ G+ H D+A VY E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAE---VPKSK---ALEAVKLAIEAGFHHIDSAHVYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
>J04794-1|AAA51711.1| 325|Homo sapiens ALDR1 protein.
Length = 325
Score = 77.4 bits (182), Expect = 5e-14
Identities = 50/155 (32%), Positives = 72/155 (46%), Gaps = 12/155 (7%)
Frame = +3
Query: 255 EAVKMKVEEG-VVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIG 431
EA+K V G V RE++F+T+KLWNT+H +V A+ +L L L+Y+DLYLMHWP
Sbjct: 58 EALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYA 117
Query: 432 L---------NAD--YSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKAL 578
NAD + + ETW+ LE G ++A S A
Sbjct: 118 FERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS 177
Query: 579 SNLMLFK*RVTSKTFQKEMVEFCQSESVVVMGYSP 683
+ + Q E++ CQ+ + V YSP
Sbjct: 178 VRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSP 212
Score = 48.0 bits (109), Expect = 3e-05
Identities = 26/67 (38%), Positives = 38/67 (56%)
Frame = +1
Query: 58 MEVPSLKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYE 237
M + ++ G+ MP IGLGT+ KS+ Q++ V A+ VGYRH D A++Y
Sbjct: 1 MAASCVLLHTGQKMPLIGLGTW---------KSEPGQVKAAVKYALSVGYRHIDCAAIYG 51
Query: 238 TEQEIGK 258
E EIG+
Sbjct: 52 NEPEIGE 58
>D17793-1|BAA04619.2| 325|Homo sapiens KIAA0119 protein.
Length = 325
Score = 77.4 bits (182), Expect = 5e-14
Identities = 50/154 (32%), Positives = 78/154 (50%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW+T HR V A+ +SLKK LDY+DLYL+H P+ L
Sbjct: 66 AIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLK 125
Query: 435 -NADYSHSD---------VDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
+ S +D VD TW +E + G K+ K
Sbjct: 126 PGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLK 185
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + + ++++FC+S+ +V++ YS
Sbjct: 186 YKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYS 219
Score = 46.0 bits (104), Expect = 1e-04
Identities = 23/61 (37%), Positives = 37/61 (60%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V +SK +V AI+ G+RH D+A +Y E+++
Sbjct: 10 VKLNDGHFMPVLGFGTYAPPE---VPRSK---ALEVTKLAIEAGFRHIDSAHLYNNEEQV 63
Query: 253 G 255
G
Sbjct: 64 G 64
Score = 38.7 bits (86), Expect = 0.020
Identities = 20/42 (47%), Positives = 27/42 (64%), Gaps = 2/42 (4%)
Frame = +2
Query: 491 RCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+C G+ K IG+SNFN++QLE +L K G KP Q+E H
Sbjct: 155 KCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECH 196
>CR457010-1|CAG33291.1| 325|Homo sapiens AKR1A1 protein.
Length = 325
Score = 77.4 bits (182), Expect = 5e-14
Identities = 50/155 (32%), Positives = 72/155 (46%), Gaps = 12/155 (7%)
Frame = +3
Query: 255 EAVKMKVEEG-VVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIG 431
EA+K V G V RE++F+T+KLWNT+H +V A+ +L L L+Y+DLYLMHWP
Sbjct: 58 EALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYA 117
Query: 432 L---------NAD--YSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKAL 578
NAD + + ETW+ LE G ++A S A
Sbjct: 118 FERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS 177
Query: 579 SNLMLFK*RVTSKTFQKEMVEFCQSESVVVMGYSP 683
+ + Q E++ CQ+ + V YSP
Sbjct: 178 VRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSP 212
Score = 48.0 bits (109), Expect = 3e-05
Identities = 26/67 (38%), Positives = 38/67 (56%)
Frame = +1
Query: 58 MEVPSLKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYE 237
M + ++ G+ MP IGLGT+ KS+ Q++ V A+ VGYRH D A++Y
Sbjct: 1 MAASCVLLHTGQKMPLIGLGTW---------KSEPGQVKAAVKYALSVGYRHIDCAAIYG 51
Query: 238 TEQEIGK 258
E EIG+
Sbjct: 52 NEPEIGE 58
>BT007286-1|AAP35950.1| 323|Homo sapiens aldo-keto reductase family
1, member C3 (3-alpha hydroxysteroid dehydrogenase,
protein.
Length = 323
Score = 77.4 bits (182), Expect = 5e-14
Identities = 50/154 (32%), Positives = 78/154 (50%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW+T HR V A+ +SLKK LDY+DLYL+H P+ L
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLK 123
Query: 435 -NADYSHSD---------VDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
+ S +D VD TW +E + G K+ K
Sbjct: 124 PGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + + ++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYS 217
Score = 46.0 bits (104), Expect = 1e-04
Identities = 23/61 (37%), Positives = 37/61 (60%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V +SK +V AI+ G+RH D+A +Y E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPPE---VPRSK---ALEVTKLAIEAGFRHIDSAHLYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
Score = 38.7 bits (86), Expect = 0.020
Identities = 20/42 (47%), Positives = 27/42 (64%), Gaps = 2/42 (4%)
Frame = +2
Query: 491 RCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+C G+ K IG+SNFN++QLE +L K G KP Q+E H
Sbjct: 153 KCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECH 194
>BT007003-1|AAP35649.1| 325|Homo sapiens aldo-keto reductase family
1, member A1 (aldehyde reductase) protein.
Length = 325
Score = 77.4 bits (182), Expect = 5e-14
Identities = 50/155 (32%), Positives = 72/155 (46%), Gaps = 12/155 (7%)
Frame = +3
Query: 255 EAVKMKVEEG-VVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIG 431
EA+K V G V RE++F+T+KLWNT+H +V A+ +L L L+Y+DLYLMHWP
Sbjct: 58 EALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYA 117
Query: 432 L---------NAD--YSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKAL 578
NAD + + ETW+ LE G ++A S A
Sbjct: 118 FERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS 177
Query: 579 SNLMLFK*RVTSKTFQKEMVEFCQSESVVVMGYSP 683
+ + Q E++ CQ+ + V YSP
Sbjct: 178 VRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSP 212
Score = 48.0 bits (109), Expect = 3e-05
Identities = 26/67 (38%), Positives = 38/67 (56%)
Frame = +1
Query: 58 MEVPSLKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYE 237
M + ++ G+ MP IGLGT+ KS+ Q++ V A+ VGYRH D A++Y
Sbjct: 1 MAASCVLLHTGQKMPLIGLGTW---------KSEPGQVKAAVKYALSVGYRHIDCAAIYG 51
Query: 238 TEQEIGK 258
E EIG+
Sbjct: 52 NEPEIGE 58
>BC019230-1|AAH19230.1| 323|Homo sapiens aldo-keto reductase family
1, member C3 (3-alpha hydroxysteroid dehydrogenase,
protein.
Length = 323
Score = 77.4 bits (182), Expect = 5e-14
Identities = 50/154 (32%), Positives = 78/154 (50%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW+T HR V A+ +SLKK LDY+DLYL+H P+ L
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLK 123
Query: 435 -NADYSHSD---------VDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
+ S +D VD TW +E + G K+ K
Sbjct: 124 PGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + + ++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYS 217
Score = 46.0 bits (104), Expect = 1e-04
Identities = 23/61 (37%), Positives = 37/61 (60%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V +SK +V AI+ G+RH D+A +Y E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPPE---VPRSK---ALEVTKLAIEAGFRHIDSAHLYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
Score = 38.7 bits (86), Expect = 0.020
Identities = 20/42 (47%), Positives = 27/42 (64%), Gaps = 2/42 (4%)
Frame = +2
Query: 491 RCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+C G+ K IG+SNFN++QLE +L K G KP Q+E H
Sbjct: 153 KCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECH 194
>BC005394-1|AAH05394.1| 325|Homo sapiens aldo-keto reductase family
1, member A1 (aldehyde reductase) protein.
Length = 325
Score = 77.4 bits (182), Expect = 5e-14
Identities = 50/155 (32%), Positives = 72/155 (46%), Gaps = 12/155 (7%)
Frame = +3
Query: 255 EAVKMKVEEG-VVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIG 431
EA+K V G V RE++F+T+KLWNT+H +V A+ +L L L+Y+DLYLMHWP
Sbjct: 58 EALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYA 117
Query: 432 L---------NAD--YSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKAL 578
NAD + + ETW+ LE G ++A S A
Sbjct: 118 FERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS 177
Query: 579 SNLMLFK*RVTSKTFQKEMVEFCQSESVVVMGYSP 683
+ + Q E++ CQ+ + V YSP
Sbjct: 178 VRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSP 212
Score = 48.0 bits (109), Expect = 3e-05
Identities = 26/67 (38%), Positives = 38/67 (56%)
Frame = +1
Query: 58 MEVPSLKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYE 237
M + ++ G+ MP IGLGT+ KS+ Q++ V A+ VGYRH D A++Y
Sbjct: 1 MAASCVLLHTGQKMPLIGLGTW---------KSEPGQVKAAVKYALSVGYRHIDCAAIYG 51
Query: 238 TEQEIGK 258
E EIG+
Sbjct: 52 NEPEIGE 58
>BC001479-1|AAH01479.1| 323|Homo sapiens aldo-keto reductase family
1, member C3 (3-alpha hydroxysteroid dehydrogenase,
protein.
Length = 323
Score = 77.4 bits (182), Expect = 5e-14
Identities = 50/154 (32%), Positives = 78/154 (50%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW+T HR V A+ +SLKK LDY+DLYL+H P+ L
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLK 123
Query: 435 -NADYSHSD---------VDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
+ S +D VD TW +E + G K+ K
Sbjct: 124 PGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + + ++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYS 217
Score = 46.0 bits (104), Expect = 1e-04
Identities = 23/61 (37%), Positives = 37/61 (60%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V +SK +V AI+ G+RH D+A +Y E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPPE---VPRSK---ALEVTKLAIEAGFRHIDSAHLYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
Score = 38.7 bits (86), Expect = 0.020
Identities = 20/42 (47%), Positives = 27/42 (64%), Gaps = 2/42 (4%)
Frame = +2
Query: 491 RCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+C G+ K IG+SNFN++QLE +L K G KP Q+E H
Sbjct: 153 KCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECH 194
>BC000670-1|AAH00670.1| 325|Homo sapiens aldo-keto reductase family
1, member A1 (aldehyde reductase) protein.
Length = 325
Score = 77.4 bits (182), Expect = 5e-14
Identities = 50/155 (32%), Positives = 72/155 (46%), Gaps = 12/155 (7%)
Frame = +3
Query: 255 EAVKMKVEEG-VVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIG 431
EA+K V G V RE++F+T+KLWNT+H +V A+ +L L L+Y+DLYLMHWP
Sbjct: 58 EALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYA 117
Query: 432 L---------NAD--YSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKAL 578
NAD + + ETW+ LE G ++A S A
Sbjct: 118 FERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS 177
Query: 579 SNLMLFK*RVTSKTFQKEMVEFCQSESVVVMGYSP 683
+ + Q E++ CQ+ + V YSP
Sbjct: 178 VRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSP 212
Score = 48.0 bits (109), Expect = 3e-05
Identities = 26/67 (38%), Positives = 38/67 (56%)
Frame = +1
Query: 58 MEVPSLKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYE 237
M + ++ G+ MP IGLGT+ KS+ Q++ V A+ VGYRH D A++Y
Sbjct: 1 MAASCVLLHTGQKMPLIGLGTW---------KSEPGQVKAAVKYALSVGYRHIDCAAIYG 51
Query: 238 TEQEIGK 258
E EIG+
Sbjct: 52 NEPEIGE 58
>AL391427-4|CAI14729.1| 323|Homo sapiens aldo-keto reductase family
1, member C3 (3-alpha hydroxysteroid dehydrogenase,
protein.
Length = 323
Score = 77.4 bits (182), Expect = 5e-14
Identities = 50/154 (32%), Positives = 78/154 (50%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW+T HR V A+ +SLKK LDY+DLYL+H P+ L
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLK 123
Query: 435 -NADYSHSD---------VDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
+ S +D VD TW +E + G K+ K
Sbjct: 124 PGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + + ++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYS 217
Score = 46.0 bits (104), Expect = 1e-04
Identities = 23/61 (37%), Positives = 37/61 (60%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V +SK +V AI+ G+RH D+A +Y E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPPE---VPRSK---ALEVTKLAIEAGFRHIDSAHLYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
Score = 38.7 bits (86), Expect = 0.020
Identities = 20/42 (47%), Positives = 27/42 (64%), Gaps = 2/42 (4%)
Frame = +2
Query: 491 RCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+C G+ K IG+SNFN++QLE +L K G KP Q+E H
Sbjct: 153 KCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECH 194
>AL355480-3|CAI22459.1| 325|Homo sapiens aldo-keto reductase family
1, member A1 (aldehydetase, 1 protein.
Length = 325
Score = 77.4 bits (182), Expect = 5e-14
Identities = 50/155 (32%), Positives = 72/155 (46%), Gaps = 12/155 (7%)
Frame = +3
Query: 255 EAVKMKVEEG-VVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIG 431
EA+K V G V RE++F+T+KLWNT+H +V A+ +L L L+Y+DLYLMHWP
Sbjct: 58 EALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYA 117
Query: 432 L---------NAD--YSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKAL 578
NAD + + ETW+ LE G ++A S A
Sbjct: 118 FERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS 177
Query: 579 SNLMLFK*RVTSKTFQKEMVEFCQSESVVVMGYSP 683
+ + Q E++ CQ+ + V YSP
Sbjct: 178 VRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSP 212
Score = 48.0 bits (109), Expect = 3e-05
Identities = 26/67 (38%), Positives = 38/67 (56%)
Frame = +1
Query: 58 MEVPSLKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYE 237
M + ++ G+ MP IGLGT+ KS+ Q++ V A+ VGYRH D A++Y
Sbjct: 1 MAASCVLLHTGQKMPLIGLGTW---------KSEPGQVKAAVKYALSVGYRHIDCAAIYG 51
Query: 238 TEQEIGK 258
E EIG+
Sbjct: 52 NEPEIGE 58
>AF112485-1|AAF01260.1| 325|Homo sapiens aldehyde reductase
protein.
Length = 325
Score = 77.4 bits (182), Expect = 5e-14
Identities = 50/155 (32%), Positives = 72/155 (46%), Gaps = 12/155 (7%)
Frame = +3
Query: 255 EAVKMKVEEG-VVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIG 431
EA+K V G V RE++F+T+KLWNT+H +V A+ +L L L+Y+DLYLMHWP
Sbjct: 58 EALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYA 117
Query: 432 L---------NAD--YSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKAL 578
NAD + + ETW+ LE G ++A S A
Sbjct: 118 FERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS 177
Query: 579 SNLMLFK*RVTSKTFQKEMVEFCQSESVVVMGYSP 683
+ + Q E++ CQ+ + V YSP
Sbjct: 178 VRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSP 212
Score = 48.0 bits (109), Expect = 3e-05
Identities = 26/67 (38%), Positives = 38/67 (56%)
Frame = +1
Query: 58 MEVPSLKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYE 237
M + ++ G+ MP IGLGT+ KS+ Q++ V A+ VGYRH D A++Y
Sbjct: 1 MAASCVLLHTGQKMPLIGLGTW---------KSEPGQVKAAVKYALSVGYRHIDCAAIYG 51
Query: 238 TEQEIGK 258
E EIG+
Sbjct: 52 NEPEIGE 58
>AF036683-1|AAB92369.1| 325|Homo sapiens aldehyde reductase
protein.
Length = 325
Score = 77.4 bits (182), Expect = 5e-14
Identities = 50/155 (32%), Positives = 72/155 (46%), Gaps = 12/155 (7%)
Frame = +3
Query: 255 EAVKMKVEEG-VVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIG 431
EA+K V G V RE++F+T+KLWNT+H +V A+ +L L L+Y+DLYLMHWP
Sbjct: 58 EALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYA 117
Query: 432 L---------NAD--YSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKAL 578
NAD + + ETW+ LE G ++A S A
Sbjct: 118 FERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS 177
Query: 579 SNLMLFK*RVTSKTFQKEMVEFCQSESVVVMGYSP 683
+ + Q E++ CQ+ + V YSP
Sbjct: 178 VRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSP 212
Score = 48.0 bits (109), Expect = 3e-05
Identities = 26/67 (38%), Positives = 38/67 (56%)
Frame = +1
Query: 58 MEVPSLKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYE 237
M + ++ G+ MP IGLGT+ KS+ Q++ V A+ VGYRH D A++Y
Sbjct: 1 MAASCVLLHTGQKMPLIGLGTW---------KSEPGQVKAAVKYALSVGYRHIDCAAIYG 51
Query: 238 TEQEIGK 258
E EIG+
Sbjct: 52 NEPEIGE 58
>AB032157-1|BAA92892.1| 323|Homo sapiens prostaglandin F synthase
protein.
Length = 323
Score = 77.4 bits (182), Expect = 5e-14
Identities = 50/154 (32%), Positives = 78/154 (50%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW+T HR V A+ +SLKK LDY+DLYL+H P+ L
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLK 123
Query: 435 -NADYSHSD---------VDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
+ S +D VD TW +E + G K+ K
Sbjct: 124 PGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + + ++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYS 217
Score = 46.0 bits (104), Expect = 1e-04
Identities = 23/61 (37%), Positives = 37/61 (60%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V +SK +V AI+ G+RH D+A +Y E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPPE---VPRSK---ALEVTKLAIEAGFRHIDSAHLYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
Score = 38.7 bits (86), Expect = 0.020
Identities = 20/42 (47%), Positives = 27/42 (64%), Gaps = 2/42 (4%)
Frame = +2
Query: 491 RCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+C G+ K IG+SNFN++QLE +L K G KP Q+E H
Sbjct: 153 KCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECH 194
>AB018580-1|BAA88488.1| 323|Homo sapiens hluPGFS protein.
Length = 323
Score = 77.4 bits (182), Expect = 5e-14
Identities = 50/154 (32%), Positives = 78/154 (50%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW+T HR V A+ +SLKK LDY+DLYL+H P+ L
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLK 123
Query: 435 -NADYSHSD---------VDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
+ S +D VD TW +E + G K+ K
Sbjct: 124 PGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + + ++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYS 217
Score = 46.0 bits (104), Expect = 1e-04
Identities = 23/61 (37%), Positives = 37/61 (60%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V +SK +V AI+ G+RH D+A +Y E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPPE---VPRSK---ALEVTKLAIEAGFRHIDSAHLYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
Score = 38.7 bits (86), Expect = 0.020
Identities = 20/42 (47%), Positives = 27/42 (64%), Gaps = 2/42 (4%)
Frame = +2
Query: 491 RCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+C G+ K IG+SNFN++QLE +L K G KP Q+E H
Sbjct: 153 KCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECH 194
>U05861-1|AAA18115.1| 323|Homo sapiens hepatic dihydrodiol
dehydrogenase protein.
Length = 323
Score = 77.0 bits (181), Expect = 6e-14
Identities = 48/154 (31%), Positives = 74/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW HR V A+ SLK L LDY+DLYL+H+P+ +
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 124 PGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q+++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYS 217
Score = 46.4 bits (105), Expect = 1e-04
Identities = 23/61 (37%), Positives = 37/61 (60%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V KSK + + AI+ G+RH D+A +Y E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAE---VPKSKALEATKL---AIEAGFRHIDSAHLYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
Score = 39.1 bits (87), Expect = 0.015
Identities = 20/44 (45%), Positives = 28/44 (63%), Gaps = 2/44 (4%)
Frame = +2
Query: 485 IGRCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+ +C G+ K IG+SNFN++QLE +L K G KP Q+E H
Sbjct: 151 VEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECH 194
>U05684-1|AAA16227.1| 323|Homo sapiens dihydrodiol dehydrogenase
protein.
Length = 323
Score = 77.0 bits (181), Expect = 6e-14
Identities = 48/154 (31%), Positives = 74/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW HR V A+ SLK L LDY+DLYL+H+P+ +
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 124 PGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q+++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYS 217
Score = 46.4 bits (105), Expect = 1e-04
Identities = 23/61 (37%), Positives = 37/61 (60%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V KSK + + AI+ G+RH D+A +Y E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAE---VPKSKALEATKL---AIEAGFRHIDSAHLYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
Score = 39.1 bits (87), Expect = 0.015
Identities = 20/44 (45%), Positives = 28/44 (63%), Gaps = 2/44 (4%)
Frame = +2
Query: 485 IGRCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+ +C G+ K IG+SNFN++QLE +L K G KP Q+E H
Sbjct: 151 VEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECH 194
>M86609-1|AAB02880.1| 323|Homo sapiens dihydrodiol dehydrogenase
protein.
Length = 323
Score = 77.0 bits (181), Expect = 6e-14
Identities = 48/154 (31%), Positives = 74/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW HR V A+ SLK L LDY+DLYL+H+P+ +
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 124 PGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q+++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYS 217
Score = 46.4 bits (105), Expect = 1e-04
Identities = 23/61 (37%), Positives = 37/61 (60%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V KSK + + AI+ G+RH D+A +Y E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAE---VPKSKALEATKL---AIEAGFRHIDSAHLYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
Score = 39.1 bits (87), Expect = 0.015
Identities = 20/44 (45%), Positives = 28/44 (63%), Gaps = 2/44 (4%)
Frame = +2
Query: 485 IGRCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+ +C G+ K IG+SNFN++QLE +L K G KP Q+E H
Sbjct: 151 VEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECH 194
>D26124-1|BAA05121.1| 306|Homo sapiens dihydrodiol dehydrogenase
isoform DD1 protein.
Length = 306
Score = 77.0 bits (181), Expect = 6e-14
Identities = 48/154 (31%), Positives = 74/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW HR V A+ SLK L LDY+DLYL+H+P+ +
Sbjct: 47 AIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 106
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 107 PGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLK 166
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q+++++FC+S+ +V++ YS
Sbjct: 167 YKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYS 200
Score = 39.1 bits (87), Expect = 0.015
Identities = 20/44 (45%), Positives = 28/44 (63%), Gaps = 2/44 (4%)
Frame = +2
Query: 485 IGRCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+ +C G+ K IG+SNFN++QLE +L K G KP Q+E H
Sbjct: 134 VEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECH 177
Score = 33.5 bits (73), Expect = 0.76
Identities = 18/50 (36%), Positives = 29/50 (58%)
Frame = +1
Query: 106 IGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEIG 255
+G GTY + V KSK + + AI+ G+RH D+A +Y E+++G
Sbjct: 2 LGFGTYAPAE---VPKSKALEATKL---AIEAGFRHIDSAHLYNNEEQVG 45
>BT007197-1|AAP35861.1| 323|Homo sapiens aldo-keto reductase family
1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha
protein.
Length = 323
Score = 77.0 bits (181), Expect = 6e-14
Identities = 48/154 (31%), Positives = 74/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW HR V A+ SLK L LDY+DLYL+H+P+ +
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 124 PGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q+++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYS 217
Score = 46.4 bits (105), Expect = 1e-04
Identities = 23/61 (37%), Positives = 37/61 (60%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V KSK + + AI+ G+RH D+A +Y E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAE---VPKSKALEATKL---AIEAGFRHIDSAHLYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
Score = 39.1 bits (87), Expect = 0.015
Identities = 20/44 (45%), Positives = 28/44 (63%), Gaps = 2/44 (4%)
Frame = +2
Query: 485 IGRCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+ +C G+ K IG+SNFN++QLE +L K G KP Q+E H
Sbjct: 151 VEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECH 194
>BC040210-1|AAH40210.1| 323|Homo sapiens aldo-keto reductase family
1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha
protein.
Length = 323
Score = 77.0 bits (181), Expect = 6e-14
Identities = 48/154 (31%), Positives = 74/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW HR V A+ SLK L LDY+DLYL+H+P+ +
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 124 PGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q+++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYS 217
Score = 46.4 bits (105), Expect = 1e-04
Identities = 23/61 (37%), Positives = 37/61 (60%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V KSK + + AI+ G+RH D+A +Y E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAE---VPKSKALEATKL---AIEAGFRHIDSAHLYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
Score = 39.1 bits (87), Expect = 0.015
Identities = 20/44 (45%), Positives = 28/44 (63%), Gaps = 2/44 (4%)
Frame = +2
Query: 485 IGRCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+ +C G+ K IG+SNFN++QLE +L K G KP Q+E H
Sbjct: 151 VEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECH 194
>BC020216-1|AAH20216.1| 323|Homo sapiens aldo-keto reductase family
1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha
protein.
Length = 323
Score = 77.0 bits (181), Expect = 6e-14
Identities = 48/154 (31%), Positives = 74/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW HR V A+ SLK L LDY+DLYL+H+P+ +
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 124 PGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q+++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYS 217
Score = 46.4 bits (105), Expect = 1e-04
Identities = 23/61 (37%), Positives = 37/61 (60%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V KSK + + AI+ G+RH D+A +Y E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAE---VPKSKALEATKL---AIEAGFRHIDSAHLYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
Score = 39.1 bits (87), Expect = 0.015
Identities = 20/44 (45%), Positives = 28/44 (63%), Gaps = 2/44 (4%)
Frame = +2
Query: 485 IGRCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+ +C G+ K IG+SNFN++QLE +L K G KP Q+E H
Sbjct: 151 VEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECH 194
>BC015490-1|AAH15490.1| 323|Homo sapiens aldo-keto reductase family
1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha
protein.
Length = 323
Score = 77.0 bits (181), Expect = 6e-14
Identities = 48/154 (31%), Positives = 74/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW HR V A+ SLK L LDY+DLYL+H+P+ +
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 124 PGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q+++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYS 217
Score = 46.4 bits (105), Expect = 1e-04
Identities = 23/61 (37%), Positives = 37/61 (60%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V KSK + + AI+ G+RH D+A +Y E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAE---VPKSKALEATKL---AIEAGFRHIDSAHLYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
Score = 39.1 bits (87), Expect = 0.015
Identities = 20/44 (45%), Positives = 28/44 (63%), Gaps = 2/44 (4%)
Frame = +2
Query: 485 IGRCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+ +C G+ K IG+SNFN++QLE +L K G KP Q+E H
Sbjct: 151 VEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECH 194
>BC005387-1|AAH05387.1| 316|Homo sapiens aldo-keto reductase family
1, member B1 (aldose reductase) protein.
Length = 316
Score = 77.0 bits (181), Expect = 6e-14
Identities = 49/162 (30%), Positives = 78/162 (48%), Gaps = 13/162 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ E VVKRE++FI +KLW T H + V A +L L LDY+DLYL+HWP G
Sbjct: 58 AIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFK 117
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
+ + SD + ++T +E+ G +KA K
Sbjct: 118 PGKEFFPLDESGNVVPSDTNILDTRAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLK 177
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYSPFRFPGXP 704
++ + Q++++++CQS+ +VV YSP P P
Sbjct: 178 YKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRP 219
Score = 54.4 bits (125), Expect = 4e-07
Identities = 29/61 (47%), Positives = 36/61 (59%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
L +NNG MP +GLGT+ KS Q+ + V AIDVGYRH D A VY+ E E+
Sbjct: 5 LLLNNGAKMPILGLGTW---------KSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEV 55
Query: 253 G 255
G
Sbjct: 56 G 56
Score = 35.1 bits (77), Expect = 0.25
Identities = 20/37 (54%), Positives = 24/37 (64%), Gaps = 2/37 (5%)
Frame = +2
Query: 506 GIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
G+VK IG+SNFN Q+E +L K G KP QIE H
Sbjct: 152 GLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECH 188
>AL713867-3|CAI16410.1| 247|Homo sapiens aldo-keto reductase family
1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha
protein.
Length = 247
Score = 77.0 bits (181), Expect = 6e-14
Identities = 48/154 (31%), Positives = 74/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW HR V A+ SLK L LDY+DLYL+H+P+ +
Sbjct: 30 AIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 89
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 90 PGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLK 149
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q+++++FC+S+ +V++ YS
Sbjct: 150 YKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYS 183
Score = 39.1 bits (87), Expect = 0.015
Identities = 20/44 (45%), Positives = 28/44 (63%), Gaps = 2/44 (4%)
Frame = +2
Query: 485 IGRCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+ +C G+ K IG+SNFN++QLE +L K G KP Q+E H
Sbjct: 117 VEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECH 160
>AL713867-2|CAI16409.1| 323|Homo sapiens aldo-keto reductase family
1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha
protein.
Length = 323
Score = 77.0 bits (181), Expect = 6e-14
Identities = 48/154 (31%), Positives = 74/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW HR V A+ SLK L LDY+DLYL+H+P+ +
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 124 PGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q+++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYS 217
Score = 46.4 bits (105), Expect = 1e-04
Identities = 23/61 (37%), Positives = 37/61 (60%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V KSK + + AI+ G+RH D+A +Y E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAE---VPKSKALEATKL---AIEAGFRHIDSAHLYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
Score = 39.1 bits (87), Expect = 0.015
Identities = 20/44 (45%), Positives = 28/44 (63%), Gaps = 2/44 (4%)
Frame = +2
Query: 485 IGRCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+ +C G+ K IG+SNFN++QLE +L K G KP Q+E H
Sbjct: 151 VEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECH 194
>AB032150-1|BAA92886.1| 323|Homo sapiens 20 alph-hydroxysteroid
dehydrogenase protein.
Length = 323
Score = 77.0 bits (181), Expect = 6e-14
Identities = 48/154 (31%), Positives = 74/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW HR V A+ SLK L LDY+DLYL+H+P+ +
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 124 PGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q+++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYS 217
Score = 46.4 bits (105), Expect = 1e-04
Identities = 23/61 (37%), Positives = 37/61 (60%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V KSK + + AI+ G+RH D+A +Y E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAE---VPKSKALEATKL---AIEAGFRHIDSAHLYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
Score = 39.1 bits (87), Expect = 0.015
Identities = 20/44 (45%), Positives = 28/44 (63%), Gaps = 2/44 (4%)
Frame = +2
Query: 485 IGRCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+ +C G+ K IG+SNFN++QLE +L K G KP Q+E H
Sbjct: 151 VEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECH 194
>AB031083-1|BAA92883.1| 323|Homo sapiens 20 alpha-hydroxysteroid
dehydrogenase protein.
Length = 323
Score = 77.0 bits (181), Expect = 6e-14
Identities = 48/154 (31%), Positives = 74/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW HR V A+ SLK L LDY+DLYL+H+P+ +
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 124 PGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q+++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYS 217
Score = 46.4 bits (105), Expect = 1e-04
Identities = 23/61 (37%), Positives = 37/61 (60%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V KSK + + AI+ G+RH D+A +Y E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAE---VPKSKALEATKL---AIEAGFRHIDSAHLYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
Score = 39.1 bits (87), Expect = 0.015
Identities = 20/44 (45%), Positives = 28/44 (63%), Gaps = 2/44 (4%)
Frame = +2
Query: 485 IGRCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+ +C G+ K IG+SNFN++QLE +L K G KP Q+E H
Sbjct: 151 VEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECH 194
>AB040822-1|BAC54567.1| 222|Homo sapiens aldo-keto reductase
related protein 3 protein.
Length = 222
Score = 76.2 bits (179), Expect(2) = 6e-14
Identities = 31/57 (54%), Positives = 44/57 (77%)
Frame = +3
Query: 261 VKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIG 431
++ K++EG V+RED+FI TKLW T H+++ V A SLK L L+Y+DLYL+HWP+G
Sbjct: 50 IRCKIKEGAVRREDLFIATKLWCTCHKKSLVETACRKSLKALKLNYLDLYLIHWPMG 106
Score = 39.9 bits (89), Expect = 0.009
Identities = 20/53 (37%), Positives = 30/53 (56%)
Frame = +1
Query: 97 MPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEIG 255
+PA+GL ++ K+ ++ + V AID GYRHFD A Y E+E+G
Sbjct: 4 IPAVGLSSW---------KASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVG 47
Score = 21.0 bits (42), Expect(2) = 6e-14
Identities = 6/9 (66%), Positives = 8/9 (88%)
Frame = +3
Query: 453 SDVDFMETW 479
SD DF++TW
Sbjct: 144 SDTDFLDTW 152
>S68330-1|AAD14013.1| 323|Homo sapiens chlordecone reductase
homolog protein.
Length = 323
Score = 76.2 bits (179), Expect = 1e-13
Identities = 47/154 (30%), Positives = 75/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW+ HR V A+ SLK L LDY+DLYL+H+P+ +
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ +
Sbjct: 124 PGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNEPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q+++++FC+S+ +V++ YS
Sbjct: 184 YEPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYS 217
Score = 47.2 bits (107), Expect = 6e-05
Identities = 24/61 (39%), Positives = 36/61 (59%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V KSK + V AI+ G+ H D+A VY E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAE---VPKSK---ALEAVKLAIEAGFHHIDSAHVYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
>AF524864-1|AAO13380.1| 316|Homo sapiens aldo-ketoreductase
protein.
Length = 316
Score = 75.8 bits (178), Expect = 1e-13
Identities = 53/167 (31%), Positives = 84/167 (50%), Gaps = 17/167 (10%)
Frame = +3
Query: 255 EAVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL 434
EA++ K++E VKRED+FI +KLW T R V +A +LK L Y+D+YL+HWP G
Sbjct: 57 EAIQEKIQEKAVKREDLFIASKLWPTFFERPLVRKAFEKTLKDPKLSYLDVYLIHWPQGF 116
Query: 435 NA--DYSHSD---------VDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALS 581
+ D D F++ W +E+ G +KA S S ++ +K L+
Sbjct: 117 KSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALG--VSNFSHFQ--IEKLLN 172
Query: 582 NLMLFK*RVTSKT------FQKEMVEFCQSESVVVMGYSPFRFPGXP 704
L VT++ Q++++++C S+ + V YSP P P
Sbjct: 173 KPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRP 219
Score = 44.0 bits (99), Expect = 5e-04
Identities = 23/62 (37%), Positives = 36/62 (58%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
++++ MP +GLGT+ KS ++++ V AID GYRH D A VY+ E E+
Sbjct: 5 VELSTKAKMPIVGLGTW---------KSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEV 55
Query: 253 GK 258
G+
Sbjct: 56 GE 57
Score = 31.5 bits (68), Expect = 3.1
Identities = 17/37 (45%), Positives = 25/37 (67%), Gaps = 2/37 (5%)
Frame = +2
Query: 506 GIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
G+VK +G+SNF+ Q+E++L K G KP Q+E H
Sbjct: 152 GLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECH 188
>S68288-1|AAD14011.1| 323|Homo sapiens chlordecone reductase
homolog protein.
Length = 323
Score = 75.4 bits (177), Expect = 2e-13
Identities = 49/154 (31%), Positives = 78/154 (50%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G V+REDIF T+KLW+T HR V A+ +SLKK LDY+DLYL+H P+ L
Sbjct: 64 AIRSKIADGSVEREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLK 123
Query: 435 -NADYSHSD---------VDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
+ S +D VD TW +E + G K+ K
Sbjct: 124 PGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEIILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + + ++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYS 217
Score = 46.0 bits (104), Expect = 1e-04
Identities = 23/61 (37%), Positives = 37/61 (60%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V +SK +V AI+ G+RH D+A +Y E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPPE---VPRSK---ALEVTKLAIEAGFRHIDSAHLYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
Score = 37.9 bits (84), Expect = 0.035
Identities = 20/42 (47%), Positives = 27/42 (64%), Gaps = 2/42 (4%)
Frame = +2
Query: 491 RCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+C G+ K IG+SNFN++QLE +L K G KP Q+E H
Sbjct: 153 KCKDAGLAKSIGVSNFNRRQLEIILNKPGLKYKPVCNQVECH 194
>L43839-1|AAB41916.1| 323|Homo sapiens 3-alpha-hydroxysteroid
dehydrogenase protein.
Length = 323
Score = 74.5 bits (175), Expect = 3e-13
Identities = 49/154 (31%), Positives = 77/154 (50%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G V REDIF T+KLW+T HR V A+ +SLKK LDY+DLYL+H P+ L
Sbjct: 64 AIRSKIADGSVMREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLK 123
Query: 435 -NADYSHSD---------VDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
+ S +D VD TW +E + G K+ K
Sbjct: 124 PGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEIILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + + ++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYS 217
Score = 46.0 bits (104), Expect = 1e-04
Identities = 23/61 (37%), Positives = 37/61 (60%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V +SK +V AI+ G+RH D+A +Y E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPPE---VPRSK---ALEVTKLAIEAGFRHIDSAHLYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
Score = 37.9 bits (84), Expect = 0.035
Identities = 20/42 (47%), Positives = 27/42 (64%), Gaps = 2/42 (4%)
Frame = +2
Query: 491 RCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+C G+ K IG+SNFN++QLE +L K G KP Q+E H
Sbjct: 153 KCKDAGLAKSIGVSNFNRRQLEIILNKPGLKYKPVCNQVECH 194
>L32592-1|AAB38486.1| 323|Homo sapiens dihydrodiol
dehydrogenase/bile acid-binding protein protein.
Length = 323
Score = 74.5 bits (175), Expect = 3e-13
Identities = 47/154 (30%), Positives = 74/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW+ HR V A+ SLK L LDY DLYL+H+P+ +
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYADLYLIHFPVSVK 123
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ +
Sbjct: 124 PGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNEPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q+++++FC+S+ +V++ YS
Sbjct: 184 YEPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYS 217
Score = 48.8 bits (111), Expect = 2e-05
Identities = 25/61 (40%), Positives = 36/61 (59%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V KSK + V AI+ GY H D+A VY E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAE---VPKSK---ALEAVKLAIEAGYHHIDSAHVYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
>S68290-1|AAD14012.1| 320|Homo sapiens chlordecone reductase
homolog protein.
Length = 320
Score = 74.1 bits (174), Expect = 4e-13
Identities = 47/154 (30%), Positives = 75/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW HR A+ SLK L LDY+DLYL+H+P+ +
Sbjct: 61 AIRSKIADGSVKREDIFYTSKLWCNSHRPELDRPALERSLKNLQLDYVDLYLIHFPVSVK 120
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + K+ S+ K
Sbjct: 121 PGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAELAKSIGVSNFNRSTLEMILNKPGLQ 180
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+ +V + Q+++++FC+S+ +V++ YS
Sbjct: 181 VKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYS 214
Score = 46.4 bits (105), Expect = 1e-04
Identities = 23/61 (37%), Positives = 37/61 (60%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V KSK + + AI+ G+RH D+A +Y E+++
Sbjct: 5 VKLNDGHFMPVLGFGTYAPAE---VPKSKALEATKL---AIEAGFRHIDSAHLYNNEEQV 58
Query: 253 G 255
G
Sbjct: 59 G 59
>DQ269985-1|ABB76132.1| 323|Homo sapiens type II 3a-hydroxysteroid
dehydrogenase variant protein.
Length = 323
Score = 74.1 bits (174), Expect = 4e-13
Identities = 50/154 (32%), Positives = 75/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
AV+ K+ +G VKREDIF T+KLW HR V A+ SLKK LDY+DLYL+H P+ L
Sbjct: 64 AVRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKKAQLDYVDLYLIHSPMSLK 123
Query: 435 -NADYSHSD---------VDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
+ S +D VD TW +E + G K+ K
Sbjct: 124 PGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + + ++++FC+S+ +V++ YS
Sbjct: 184 YKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYS 217
Score = 46.4 bits (105), Expect = 1e-04
Identities = 23/61 (37%), Positives = 37/61 (60%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+K+N+G MP +G GTY + V KSK + + AI+ G+RH D+A +Y E+++
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAE---VPKSKALEATKL---AIEAGFRHIDSAHLYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
Score = 38.7 bits (86), Expect = 0.020
Identities = 20/42 (47%), Positives = 27/42 (64%), Gaps = 2/42 (4%)
Frame = +2
Query: 491 RCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+C G+ K IG+SNFN++QLE +L K G KP Q+E H
Sbjct: 153 KCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECH 194
>S68287-1|AAD14010.1| 323|Homo sapiens chlordecone reductase
protein.
Length = 323
Score = 72.9 bits (171), Expect = 1e-12
Identities = 48/154 (31%), Positives = 74/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW T + V A+ SLKKL LDY+DLYL+H+P+ L
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALK 123
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 124 PGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q ++++FC+S+ +V++ +S
Sbjct: 184 YKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHS 217
Score = 41.1 bits (92), Expect = 0.004
Identities = 20/61 (32%), Positives = 37/61 (60%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+++N+G MP +G GTY + V +++ + V AI+ G+RH D+A +Y E+++
Sbjct: 8 VELNDGHFMPVLGFGTYAPPE---VPRNRAVE---VTKLAIEAGFRHIDSAYLYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
Score = 36.7 bits (81), Expect = 0.081
Identities = 20/42 (47%), Positives = 26/42 (61%), Gaps = 2/42 (4%)
Frame = +2
Query: 491 RCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+C G+ K IG+SNFN +QLE +L K G KP Q+E H
Sbjct: 153 KCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVCNQVECH 194
>M33375-1|AAA35658.1| 308|Homo sapiens protein ( Human chlordecone
reductase mRNA, complete cds. ).
Length = 308
Score = 72.9 bits (171), Expect = 1e-12
Identities = 48/154 (31%), Positives = 74/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW T + V A+ SLKKL LDY+DLYL+H+P+ L
Sbjct: 49 AIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALK 108
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 109 PGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLK 168
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q ++++FC+S+ +V++ +S
Sbjct: 169 YKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHS 202
Score = 36.7 bits (81), Expect = 0.081
Identities = 20/42 (47%), Positives = 26/42 (61%), Gaps = 2/42 (4%)
Frame = +2
Query: 491 RCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+C G+ K IG+SNFN +QLE +L K G KP Q+E H
Sbjct: 138 KCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVCNQVECH 179
Score = 34.7 bits (76), Expect = 0.33
Identities = 18/53 (33%), Positives = 31/53 (58%)
Frame = +1
Query: 97 MPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEIG 255
MP +G GTY + V +++ + V AI+ G+RH D+A +Y E+++G
Sbjct: 1 MPVLGFGTYAPPE---VPRNRAVE---VTKLAIEAGFRHIDSAYLYNNEEQVG 47
>D26125-1|BAA05122.1| 321|Homo sapiens 3
alpha-hydroxysteroid/dihydrodiol dehydrogenase DD4
protein.
Length = 321
Score = 72.9 bits (171), Expect = 1e-12
Identities = 48/154 (31%), Positives = 74/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW T + V A+ SLKKL LDY+DLYL+H+P+ L
Sbjct: 62 AIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALK 121
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 122 PGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLK 181
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q ++++FC+S+ +V++ +S
Sbjct: 182 YKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHS 215
Score = 41.1 bits (92), Expect = 0.004
Identities = 20/61 (32%), Positives = 37/61 (60%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+++N+G MP +G GTY + V +++ + V AI+ G+RH D+A +Y E+++
Sbjct: 6 VELNDGHFMPVLGFGTYAPPE---VPRNRAVE---VTKLAIEAGFRHIDSAYLYNNEEQV 59
Query: 253 G 255
G
Sbjct: 60 G 60
Score = 36.7 bits (81), Expect = 0.081
Identities = 20/42 (47%), Positives = 26/42 (61%), Gaps = 2/42 (4%)
Frame = +2
Query: 491 RCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+C G+ K IG+SNFN +QLE +L K G KP Q+E H
Sbjct: 151 KCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVCNQVECH 192
>AL355303-2|CAI14202.1| 323|Homo sapiens aldo-keto reductase family
1, member C4 (chlordecone reductase; 3-alpha hydroxy
protein.
Length = 323
Score = 72.9 bits (171), Expect = 1e-12
Identities = 48/154 (31%), Positives = 74/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW T + V A+ SLKKL LDY+DLYL+H+P+ L
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALK 123
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 124 PGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q ++++FC+S+ +V++ +S
Sbjct: 184 YKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHS 217
Score = 41.1 bits (92), Expect = 0.004
Identities = 20/61 (32%), Positives = 37/61 (60%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+++N+G MP +G GTY + V +++ + V AI+ G+RH D+A +Y E+++
Sbjct: 8 VELNDGHFMPVLGFGTYAPPE---VPRNRAVE---VTKLAIEAGFRHIDSAYLYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
Score = 36.7 bits (81), Expect = 0.081
Identities = 20/42 (47%), Positives = 26/42 (61%), Gaps = 2/42 (4%)
Frame = +2
Query: 491 RCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+C G+ K IG+SNFN +QLE +L K G KP Q+E H
Sbjct: 153 KCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVCNQVECH 194
>AB045829-1|BAA99542.1| 323|Homo sapiens 3alpha-hydroxysteroid
dehydrogenase variant protein.
Length = 323
Score = 72.9 bits (171), Expect = 1e-12
Identities = 48/154 (31%), Positives = 74/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW T + V A+ SLKKL LDY+DLYL+H+P+ L
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALK 123
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 124 PGETPLPKDENGKVIFDTVDLCATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q ++++FC+S+ +V++ +S
Sbjct: 184 YKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHS 217
Score = 41.1 bits (92), Expect = 0.004
Identities = 20/61 (32%), Positives = 37/61 (60%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+++N+G MP +G GTY + V +++ + V AI+ G+RH D+A +Y E+++
Sbjct: 8 VELNDGHFMPVLGFGTYAPPE---VPRNRAVE---VTKLAIEAGFRHIDSAYLYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
Score = 36.7 bits (81), Expect = 0.081
Identities = 20/42 (47%), Positives = 26/42 (61%), Gaps = 2/42 (4%)
Frame = +2
Query: 491 RCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+C G+ K IG+SNFN +QLE +L K G KP Q+E H
Sbjct: 153 KCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVCNQVECH 194
>AB032163-1|BAA92893.1| 323|Homo sapiens dihydrodiol dehydrogenase
4 protein.
Length = 323
Score = 72.9 bits (171), Expect = 1e-12
Identities = 48/154 (31%), Positives = 74/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW T + V A+ SLKKL LDY+DLYL+H+P+ L
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALK 123
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 124 PGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q ++++FC+S+ +V++ +S
Sbjct: 184 YKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHS 217
Score = 41.1 bits (92), Expect = 0.004
Identities = 20/61 (32%), Positives = 37/61 (60%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+++N+G MP +G GTY + V +++ + V AI+ G+RH D+A +Y E+++
Sbjct: 8 VELNDGHFMPVLGFGTYAPPE---VPRNRAVE---VTKLAIEAGFRHIDSAYLYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
Score = 36.7 bits (81), Expect = 0.081
Identities = 20/42 (47%), Positives = 26/42 (61%), Gaps = 2/42 (4%)
Frame = +2
Query: 491 RCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+C G+ K IG+SNFN +QLE +L K G KP Q+E H
Sbjct: 153 KCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVCNQVECH 194
>AB031085-1|BAA92885.1| 323|Homo sapiens dihydrodiol dehydrogenase
4 protein.
Length = 323
Score = 72.9 bits (171), Expect = 1e-12
Identities = 48/154 (31%), Positives = 74/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW T + V A+ SLKKL LDY+DLYL+H+P+ L
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALK 123
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 124 PGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q ++++FC+S+ +V++ +S
Sbjct: 184 YKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHS 217
Score = 41.1 bits (92), Expect = 0.004
Identities = 20/61 (32%), Positives = 37/61 (60%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+++N+G MP +G GTY + V +++ + V AI+ G+RH D+A +Y E+++
Sbjct: 8 VELNDGHFMPVLGFGTYAPPE---VPRNRAVE---VTKLAIEAGFRHIDSAYLYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
Score = 36.7 bits (81), Expect = 0.081
Identities = 20/42 (47%), Positives = 26/42 (61%), Gaps = 2/42 (4%)
Frame = +2
Query: 491 RCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+C G+ K IG+SNFN +QLE +L K G KP Q+E H
Sbjct: 153 KCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVCNQVECH 194
>BC020744-1|AAH20744.1| 323|Homo sapiens aldo-keto reductase family
1, member C4 (chlordecone reductase; 3-alpha hydroxy
protein.
Length = 323
Score = 72.5 bits (170), Expect = 1e-12
Identities = 48/154 (31%), Positives = 74/154 (48%), Gaps = 13/154 (8%)
Frame = +3
Query: 258 AVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL- 434
A++ K+ +G VKREDIF T+KLW T + V A+ SLKKL LDY+DLYL+H+P+ L
Sbjct: 64 AIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALK 123
Query: 435 ----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWRGC*KKALSN 584
N VD TW +E + G K+ K
Sbjct: 124 PGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNKPGLK 183
Query: 585 LMLFK*RVTSKTF--QKEMVEFCQSESVVVMGYS 680
+V + Q ++++FC+S+ +V++ +S
Sbjct: 184 YKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHS 217
Score = 41.1 bits (92), Expect = 0.004
Identities = 20/61 (32%), Positives = 37/61 (60%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQEI 252
+++N+G MP +G GTY + V +++ + V AI+ G+RH D+A +Y E+++
Sbjct: 8 VELNDGHFMPVLGFGTYAPPE---VPRNRAVE---VTKLAIEAGFRHIDSAYLYNNEEQV 61
Query: 253 G 255
G
Sbjct: 62 G 62
Score = 37.1 bits (82), Expect = 0.061
Identities = 20/42 (47%), Positives = 26/42 (61%), Gaps = 2/42 (4%)
Frame = +2
Query: 491 RCSANGIVKGIGLSNFNKQQLERVL-KEG-TIKPDAIQIEGH 610
+C G+ K IG+SNFN +QLE +L K G KP Q+E H
Sbjct: 153 KCKDAGLAKSIGVSNFNYRQLEMILNKPGLKYKPVCNQVECH 194
>AL355480-2|CAI22458.1| 147|Homo sapiens aldo-keto reductase family
1, member A1 (aldehydela) protein.
Length = 147
Score = 68.9 bits (161), Expect = 2e-11
Identities = 37/90 (41%), Positives = 51/90 (56%), Gaps = 12/90 (13%)
Frame = +3
Query: 255 EAVKMKVEEG-VVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIG 431
EA+K V G V RE++F+T+KLWNT+H +V A+ +L L L+Y+DLYLMHWP
Sbjct: 58 EALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYA 117
Query: 432 L---------NAD--YSHSDVDFMETWRGL 488
NAD + + ETW+ L
Sbjct: 118 FERGDNPFPKNADGTICYDSTHYKETWKAL 147
Score = 48.0 bits (109), Expect = 3e-05
Identities = 26/67 (38%), Positives = 38/67 (56%)
Frame = +1
Query: 58 MEVPSLKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYE 237
M + ++ G+ MP IGLGT+ KS+ Q++ V A+ VGYRH D A++Y
Sbjct: 1 MAASCVLLHTGQKMPLIGLGTW---------KSEPGQVKAAVKYALSVGYRHIDCAAIYG 51
Query: 238 TEQEIGK 258
E EIG+
Sbjct: 52 NEPEIGE 58
>AB037902-1|BAA92887.1| 130|Homo sapiens truncated aldo-keto
reductase protein.
Length = 130
Score = 67.3 bits (157), Expect = 5e-11
Identities = 30/60 (50%), Positives = 41/60 (68%)
Frame = +3
Query: 255 EAVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL 434
+A++ K+ G VKR+DIF TTK+W T R V + + SLKKL L Y+DLYL H+P+ L
Sbjct: 64 QAIRKKIANGTVKRKDIFYTTKVWGTFSRPELVQRGLEMSLKKLQLSYMDLYLFHFPVPL 123
Score = 45.2 bits (102), Expect = 2e-04
Identities = 24/63 (38%), Positives = 36/63 (57%)
Frame = +1
Query: 70 SLKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQE 249
S+K+N+G+ MP +G GT + K + + V AIDVGYRH D+A + E+
Sbjct: 8 SVKLNDGKFMPILGFGTSVAR------KVAMSNVEEAVQVAIDVGYRHIDSAYTHLNEEG 61
Query: 250 IGK 258
IG+
Sbjct: 62 IGQ 64
>BC101205-1|AAI01206.1| 129|Homo sapiens aldo-keto reductase family
1, member C-like 1 protein.
Length = 129
Score = 63.7 bits (148), Expect = 6e-10
Identities = 29/60 (48%), Positives = 40/60 (66%)
Frame = +3
Query: 255 EAVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL 434
+A+ K+ +G VKRE+IF T KLW T R V A+ SLKKLG DY+DL+++H P +
Sbjct: 66 QAIWEKIADGTVKREEIFYTIKLWATFFRAELVHPALERSLKKLGPDYVDLFIIHVPFAM 125
Score = 49.6 bits (113), Expect = 1e-05
Identities = 25/63 (39%), Positives = 40/63 (63%)
Frame = +1
Query: 70 SLKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQE 249
S+++N+G MP +G GTY + KS+ + V AIDVG+RH D+A +Y+ E+E
Sbjct: 10 SVRLNDGPFMPVLGFGTYA---PDHTPKSQAAEATKV---AIDVGFRHIDSAYLYQNEEE 63
Query: 250 IGK 258
+G+
Sbjct: 64 VGQ 66
>BC101204-1|AAI01205.1| 129|Homo sapiens aldo-keto reductase family
1, member C-like 1 protein.
Length = 129
Score = 63.7 bits (148), Expect = 6e-10
Identities = 29/60 (48%), Positives = 40/60 (66%)
Frame = +3
Query: 255 EAVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL 434
+A+ K+ +G VKRE+IF T KLW T R V A+ SLKKLG DY+DL+++H P +
Sbjct: 66 QAIWEKIADGTVKREEIFYTIKLWATFFRAELVHPALERSLKKLGPDYVDLFIIHVPFAM 125
Score = 49.6 bits (113), Expect = 1e-05
Identities = 25/63 (39%), Positives = 40/63 (63%)
Frame = +1
Query: 70 SLKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQE 249
S+++N+G MP +G GTY + KS+ + V AIDVG+RH D+A +Y+ E+E
Sbjct: 10 SVRLNDGPFMPVLGFGTYA---PDHTPKSQAAEATKV---AIDVGFRHIDSAYLYQNEEE 63
Query: 250 IGK 258
+G+
Sbjct: 64 VGQ 66
>AL391427-2|CAI14727.1| 302|Homo sapiens aldo-keto reductase family
1, member C-like 1 protein.
Length = 302
Score = 63.7 bits (148), Expect = 6e-10
Identities = 29/60 (48%), Positives = 40/60 (66%)
Frame = +3
Query: 255 EAVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL 434
+A+ K+ +G VKRE+IF T KLW T R V A+ SLKKLG DY+DL+++H P +
Sbjct: 66 QAIWEKIADGTVKREEIFYTIKLWATFFRAELVHPALERSLKKLGPDYVDLFIIHVPFAM 125
Score = 49.6 bits (113), Expect = 1e-05
Identities = 25/63 (39%), Positives = 40/63 (63%)
Frame = +1
Query: 70 SLKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQE 249
S+++N+G MP +G GTY + KS+ + V AIDVG+RH D+A +Y+ E+E
Sbjct: 10 SVRLNDGPFMPVLGFGTYA---PDHTPKSQAAEATKV---AIDVGFRHIDSAYLYQNEEE 63
Query: 250 IGK 258
+G+
Sbjct: 64 VGQ 66
>AL355303-1|CAI14201.1| 302|Homo sapiens aldo-keto reductase family
1, member C-like 1 protein.
Length = 302
Score = 63.7 bits (148), Expect = 6e-10
Identities = 29/60 (48%), Positives = 40/60 (66%)
Frame = +3
Query: 255 EAVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL 434
+A+ K+ +G VKRE+IF T KLW T R V A+ SLKKLG DY+DL+++H P +
Sbjct: 66 QAIWEKIADGTVKREEIFYTIKLWATFFRAELVHPALERSLKKLGPDYVDLFIIHVPFAM 125
Score = 49.6 bits (113), Expect = 1e-05
Identities = 25/63 (39%), Positives = 40/63 (63%)
Frame = +1
Query: 70 SLKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQE 249
S+++N+G MP +G GTY + KS+ + V AIDVG+RH D+A +Y+ E+E
Sbjct: 10 SVRLNDGPFMPVLGFGTYA---PDHTPKSQAAEATKV---AIDVGFRHIDSAYLYQNEEE 63
Query: 250 IGK 258
+G+
Sbjct: 64 VGQ 66
>AK131335-1|BAD18494.1| 129|Homo sapiens protein ( Homo sapiens
cDNA FLJ16347 fis, clone TESTI2036288, moderately
similar to PROSTAGLANDIN-F SYNTHASE 1 (EC 1.1.1.188). ).
Length = 129
Score = 63.7 bits (148), Expect = 6e-10
Identities = 29/60 (48%), Positives = 40/60 (66%)
Frame = +3
Query: 255 EAVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL 434
+A+ K+ +G VKRE+IF T KLW T R V A+ SLKKLG DY+DL+++H P +
Sbjct: 66 QAIWEKIADGTVKREEIFYTIKLWATFFRAELVHPALERSLKKLGPDYVDLFIIHVPFAM 125
Score = 49.6 bits (113), Expect = 1e-05
Identities = 25/63 (39%), Positives = 40/63 (63%)
Frame = +1
Query: 70 SLKMNNGRXMPAIGLGTYLGFDQNGVVKSKDKQLRDVVMRAIDVGYRHFDTASVYETEQE 249
S+++N+G MP +G GTY + KS+ + V AIDVG+RH D+A +Y+ E+E
Sbjct: 10 SVRLNDGPFMPVLGFGTYA---PDHTPKSQAAEATKV---AIDVGFRHIDSAYLYQNEEE 63
Query: 250 IGK 258
+G+
Sbjct: 64 VGQ 66
>Z28339-1|CAA82193.1| 326|Homo sapiens delta 4-3-oxosteroid 5
beta-reductase protein.
Length = 326
Score = 62.1 bits (144), Expect = 2e-09
Identities = 45/160 (28%), Positives = 71/160 (44%), Gaps = 17/160 (10%)
Frame = +3
Query: 255 EAVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL 434
EA++ K+ EG V+REDIF KLW T H V + +L+ L LDY+DLY++ P+
Sbjct: 66 EAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAF 125
Query: 435 -----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWR------GC 563
N + + + TW +E + G +K+ G
Sbjct: 126 KPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGL 185
Query: 564 *KKALSNLMLFK*RVTSKTFQKEMVEFCQSESVVVMGYSP 683
K +SN + T Q ++++FCQ +V+ YSP
Sbjct: 186 KHKPVSNQVECHPYFT----QPKLLKFCQQHDIVITAYSP 221
Score = 43.2 bits (97), Expect = 0.001
Identities = 25/63 (39%), Positives = 34/63 (53%), Gaps = 1/63 (1%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDK-QLRDVVMRAIDVGYRHFDTASVYETEQE 249
+ +++G +P IGLGTY KS K V AID GYRH D A +Y+ E E
Sbjct: 10 IPLSDGNSIPIIGLGTY------SEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHE 63
Query: 250 IGK 258
+G+
Sbjct: 64 VGE 66
Score = 38.7 bits (86), Expect = 0.020
Identities = 18/41 (43%), Positives = 28/41 (68%), Gaps = 2/41 (4%)
Frame = +2
Query: 494 CSANGIVKGIGLSNFNKQQLERVLKEGTI--KPDAIQIEGH 610
C G+VK +G+SNFN++QLE +L + + KP + Q+E H
Sbjct: 157 CKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPVSNQVECH 197
>BC130627-1|AAI30628.1| 326|Homo sapiens aldo-keto reductase family
1, member D1 (delta 4-3-ketosteroid-5-beta-reductase
protein.
Length = 326
Score = 62.1 bits (144), Expect = 2e-09
Identities = 45/160 (28%), Positives = 71/160 (44%), Gaps = 17/160 (10%)
Frame = +3
Query: 255 EAVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL 434
EA++ K+ EG V+REDIF KLW T H V + +L+ L LDY+DLY++ P+
Sbjct: 66 EAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAF 125
Query: 435 -----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWR------GC 563
N + + + TW +E + G +K+ G
Sbjct: 126 KPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGL 185
Query: 564 *KKALSNLMLFK*RVTSKTFQKEMVEFCQSESVVVMGYSP 683
K +SN + T Q ++++FCQ +V+ YSP
Sbjct: 186 KHKPVSNQVECHPYFT----QPKLLKFCQQHDIVITAYSP 221
Score = 43.2 bits (97), Expect = 0.001
Identities = 25/63 (39%), Positives = 34/63 (53%), Gaps = 1/63 (1%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDK-QLRDVVMRAIDVGYRHFDTASVYETEQE 249
+ +++G +P IGLGTY KS K V AID GYRH D A +Y+ E E
Sbjct: 10 IPLSDGNSIPIIGLGTY------SEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHE 63
Query: 250 IGK 258
+G+
Sbjct: 64 VGE 66
Score = 38.7 bits (86), Expect = 0.020
Identities = 18/41 (43%), Positives = 28/41 (68%), Gaps = 2/41 (4%)
Frame = +2
Query: 494 CSANGIVKGIGLSNFNKQQLERVLKEGTI--KPDAIQIEGH 610
C G+VK +G+SNFN++QLE +L + + KP + Q+E H
Sbjct: 157 CKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPVSNQVECH 197
>BC130625-1|AAI30626.1| 326|Homo sapiens aldo-keto reductase family
1, member D1 (delta 4-3-ketosteroid-5-beta-reductase
protein.
Length = 326
Score = 62.1 bits (144), Expect = 2e-09
Identities = 45/160 (28%), Positives = 71/160 (44%), Gaps = 17/160 (10%)
Frame = +3
Query: 255 EAVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL 434
EA++ K+ EG V+REDIF KLW T H V + +L+ L LDY+DLY++ P+
Sbjct: 66 EAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAF 125
Query: 435 -----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWR------GC 563
N + + + TW +E + G +K+ G
Sbjct: 126 KPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGL 185
Query: 564 *KKALSNLMLFK*RVTSKTFQKEMVEFCQSESVVVMGYSP 683
K +SN + T Q ++++FCQ +V+ YSP
Sbjct: 186 KHKPVSNQVECHPYFT----QPKLLKFCQQHDIVITAYSP 221
Score = 43.2 bits (97), Expect = 0.001
Identities = 25/63 (39%), Positives = 34/63 (53%), Gaps = 1/63 (1%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDK-QLRDVVMRAIDVGYRHFDTASVYETEQE 249
+ +++G +P IGLGTY KS K V AID GYRH D A +Y+ E E
Sbjct: 10 IPLSDGNSIPIIGLGTY------SEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHE 63
Query: 250 IGK 258
+G+
Sbjct: 64 VGE 66
Score = 38.7 bits (86), Expect = 0.020
Identities = 18/41 (43%), Positives = 28/41 (68%), Gaps = 2/41 (4%)
Frame = +2
Query: 494 CSANGIVKGIGLSNFNKQQLERVLKEGTI--KPDAIQIEGH 610
C G+VK +G+SNFN++QLE +L + + KP + Q+E H
Sbjct: 157 CKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPVSNQVECH 197
>AF283659-1|AAG39381.1| 326|Homo sapiens 5-beta steroid reductase
protein.
Length = 326
Score = 62.1 bits (144), Expect = 2e-09
Identities = 45/160 (28%), Positives = 71/160 (44%), Gaps = 17/160 (10%)
Frame = +3
Query: 255 EAVKMKVEEGVVKREDIFITTKLWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL 434
EA++ K+ EG V+REDIF KLW T H V + +L+ L LDY+DLY++ P+
Sbjct: 66 EAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAF 125
Query: 435 -----------NADYSHSDVDFMETWRGLEDAQRMG*LKASDCLTSTSSSWR------GC 563
N + + + TW +E + G +K+ G
Sbjct: 126 KPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGL 185
Query: 564 *KKALSNLMLFK*RVTSKTFQKEMVEFCQSESVVVMGYSP 683
K +SN + T Q ++++FCQ +V+ YSP
Sbjct: 186 KHKPVSNQVECHPYFT----QPKLLKFCQQHDIVITAYSP 221
Score = 43.2 bits (97), Expect = 0.001
Identities = 25/63 (39%), Positives = 34/63 (53%), Gaps = 1/63 (1%)
Frame = +1
Query: 73 LKMNNGRXMPAIGLGTYLGFDQNGVVKSKDK-QLRDVVMRAIDVGYRHFDTASVYETEQE 249
+ +++G +P IGLGTY KS K V AID GYRH D A +Y+ E E
Sbjct: 10 IPLSDGNSIPIIGLGTY------SEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHE 63
Query: 250 IGK 258
+G+
Sbjct: 64 VGE 66
Score = 38.7 bits (86), Expect = 0.020
Identities = 18/41 (43%), Positives = 28/41 (68%), Gaps = 2/41 (4%)
Frame = +2
Query: 494 CSANGIVKGIGLSNFNKQQLERVLKEGTI--KPDAIQIEGH 610
C G+VK +G+SNFN++QLE +L + + KP + Q+E H
Sbjct: 157 CKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPVSNQVECH 197
>AB037905-2|BAA92890.1| 45|Homo sapiens truncated aldo-keto
reductase protein.
Length = 45
Score = 39.9 bits (89), Expect = 0.009
Identities = 18/38 (47%), Positives = 24/38 (63%)
Frame = +3
Query: 321 LWNTQHRRTEVAQAINDSLKKLGLDYIDLYLMHWPIGL 434
+W T R V + + SLKKL L Y+DLYL H+P+ L
Sbjct: 1 VWGTFSRPELVQRGLEMSLKKLQLSYMDLYLFHFPVPL 38
>AK058142-1|BAB71682.1| 146|Homo sapiens protein ( Homo sapiens
cDNA FLJ25413 fis, clone TST03402, highly similar to
3-OXO-5-BETA-STEROID 4-DEHYDROGENASE (EC 1.3.99.6). ).
Length = 146
Score = 38.7 bits (86), Expect = 0.020
Identities = 18/41 (43%), Positives = 28/41 (68%), Gaps = 2/41 (4%)
Frame = +2
Query: 494 CSANGIVKGIGLSNFNKQQLERVLKEGTI--KPDAIQIEGH 610
C G+VK +G+SNFN++QLE +L + + KP + Q+E H
Sbjct: 35 CKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPVSNQVECH 75
>AB028065-1|BAA88489.1| 67|Homo sapiens prostaglandin F synthase
protein.
Length = 67
Score = 36.3 bits (80), Expect = 0.11
Identities = 14/31 (45%), Positives = 22/31 (70%)
Frame = +2
Query: 491 RCSANGIVKGIGLSNFNKQQLERVLKEGTIK 583
+C G+ K IG+SNFN++QLE +L + +K
Sbjct: 30 KCKDAGLAKSIGVSNFNRRQLEMILNKPGLK 60
>AK125347-1|BAC86140.1| 277|Homo sapiens protein ( Homo sapiens
cDNA FLJ43357 fis, clone NT2RP7013795, weakly similar
to VEGETATIBLE INCOMPATIBILITY PROTEIN HET-E-1. ).
Length = 277
Score = 31.1 bits (67), Expect = 4.0
Identities = 18/49 (36%), Positives = 24/49 (48%)
Frame = -1
Query: 172 GAACPWTSLRRSDQTQGTCPGRWRACXCRCSFLTRALPSLTPAQAPTGT 26
G+ P LR ++G+ RW A CS A P TPAQ P+G+
Sbjct: 171 GSEVPRGPLRPRAASRGSSATRWAAPPRPCSRPDPAGPLQTPAQTPSGS 219
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 108,258,629
Number of Sequences: 237096
Number of extensions: 2359737
Number of successful extensions: 4569
Number of sequences better than 10.0: 94
Number of HSP's better than 10.0 without gapping: 4172
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4478
length of database: 76,859,062
effective HSP length: 88
effective length of database: 55,994,614
effective search space used: 8231208258
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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