Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= e96h0393
(845 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_O01382 Cluster: Caspase precursor (EC 3.4.22.-) (drICE)... 158 1e-37
UniRef50_UPI0000D55B5F Cluster: PREDICTED: similar to Caspase pr... 154 3e-36
UniRef50_UPI00015B57EE Cluster: PREDICTED: similar to ENSANGP000... 114 2e-24
UniRef50_UPI00015B4D75 Cluster: PREDICTED: similar to CG7788-PA;... 113 5e-24
UniRef50_Q98UI8 Cluster: Caspase-3; n=4; Chordata|Rep: Caspase-3... 104 3e-21
UniRef50_Q7Q1E0 Cluster: ENSANGP00000015118; n=2; Culicidae|Rep:... 99 7e-20
UniRef50_P55210 Cluster: Caspase-7 precursor (EC 3.4.22.60) (CAS... 97 6e-19
UniRef50_Q5DD62 Cluster: SJCHGC00800 protein; n=3; Schistosoma j... 93 8e-18
UniRef50_Q17FE3 Cluster: Caspase-1; n=3; Endopterygota|Rep: Casp... 92 1e-17
UniRef50_P55213 Cluster: Caspase-3 precursor (EC 3.4.22.56) (CAS... 88 2e-16
UniRef50_UPI0000E48555 Cluster: PREDICTED: similar to Lice2 cyst... 86 9e-16
UniRef50_Q7Q802 Cluster: ENSANGP00000021365; n=4; Cellia|Rep: EN... 84 5e-15
UniRef50_UPI0000519DFF Cluster: PREDICTED: similar to Caspase pr... 83 1e-14
UniRef50_UPI0000E49D20 Cluster: PREDICTED: hypothetical protein;... 80 8e-14
UniRef50_Q8JIS8 Cluster: Caspase 3A; n=3; Euteleostomi|Rep: Casp... 80 8e-14
UniRef50_Q7Q803 Cluster: ENSANGP00000021367; n=6; Anopheles gamb... 79 1e-13
UniRef50_Q8I6Y2 Cluster: Caspase-3; n=2; Geodia cydonium|Rep: Ca... 63 1e-13
UniRef50_Q92851-2 Cluster: Isoform B of Q92851 ; n=9; Mammalia|R... 77 7e-13
UniRef50_Q2TM51 Cluster: Caspase; n=3; Penaeidae|Rep: Caspase - ... 77 7e-13
UniRef50_Q6KF63 Cluster: Caspase 10; n=3; Catarrhini|Rep: Caspas... 77 7e-13
UniRef50_Q92851 Cluster: Caspase-10 precursor (EC 3.4.22.63) (CA... 77 7e-13
UniRef50_A1L2P4 Cluster: LOC100036910 protein; n=1; Xenopus laev... 74 4e-12
UniRef50_P55212 Cluster: Caspase-6 precursor (EC 3.4.22.59) (CAS... 74 4e-12
UniRef50_Q9NHF9 Cluster: Caspase 6-like protein BG2; n=3; Sophop... 74 5e-12
UniRef50_Q3HL92 Cluster: Caspase-like protein; n=6; Eumetazoa|Re... 73 7e-12
UniRef50_Q7QKT2 Cluster: ENSANGP00000015505; n=3; Anopheles gamb... 73 1e-11
UniRef50_UPI0000F21D96 Cluster: PREDICTED: hypothetical protein,... 72 2e-11
UniRef50_A7SPA7 Cluster: Predicted protein; n=1; Nematostella ve... 72 2e-11
UniRef50_Q4RG79 Cluster: Chromosome 2 SCAF15106, whole genome sh... 71 3e-11
UniRef50_UPI0000F2097E Cluster: PREDICTED: hypothetical protein;... 71 5e-11
UniRef50_A7S4V9 Cluster: Predicted protein; n=2; Nematostella ve... 70 6e-11
UniRef50_Q14790 Cluster: Caspase-8 precursor (EC 3.4.22.61) (CAS... 69 1e-10
UniRef50_Q4V923 Cluster: Zgc:101776 protein; n=8; Clupeocephala|... 68 3e-10
UniRef50_Q0WYJ4 Cluster: Caspase 10; n=4; Percomorpha|Rep: Caspa... 67 5e-10
UniRef50_Q8ITP2 Cluster: AmphiCASP-6; n=2; Chordata|Rep: AmphiCA... 66 8e-10
UniRef50_Q56VC9 Cluster: Caspase-8; n=3; Euteleostei|Rep: Caspas... 66 1e-09
UniRef50_A2BGE2 Cluster: Novel protein similar to caspase 8; n=4... 66 1e-09
UniRef50_A7S119 Cluster: Predicted protein; n=1; Nematostella ve... 66 1e-09
UniRef50_Q9I8J3 Cluster: Caspase-8; n=11; Danio rerio|Rep: Caspa... 65 2e-09
UniRef50_Q5C0Y4 Cluster: SJCHGC07329 protein; n=1; Schistosoma j... 65 2e-09
UniRef50_UPI0000586459 Cluster: PREDICTED: similar to caspase-3,... 65 2e-09
UniRef50_UPI0000F2DFE7 Cluster: PREDICTED: similar to apoptotic ... 64 3e-09
UniRef50_Q90WU0 Cluster: Caspase 9; n=2; Gallus gallus|Rep: Casp... 64 3e-09
UniRef50_Q4SC67 Cluster: Chromosome undetermined SCAF14659, whol... 64 3e-09
UniRef50_UPI0001554FA5 Cluster: PREDICTED: similar to initiator ... 64 4e-09
UniRef50_Q09HM6 Cluster: Caspase-8; n=1; Molgula tectiformis|Rep... 64 4e-09
UniRef50_A5JSK5 Cluster: Cysteine protease; n=2; Eukaryota|Rep: ... 64 6e-09
UniRef50_Q69HP8 Cluster: Caspase-1-like; n=1; Ciona intestinalis... 64 6e-09
UniRef50_UPI00015553DC Cluster: PREDICTED: similar to caspase-15... 63 7e-09
UniRef50_UPI0000ECB87F Cluster: Caspase-10 precursor (EC 3.4.22.... 63 1e-08
UniRef50_UPI0000E48C15 Cluster: PREDICTED: similar to caspase 8;... 62 2e-08
UniRef50_UPI0000E472FD Cluster: PREDICTED: similar to caspase 8;... 62 2e-08
UniRef50_UPI0000587370 Cluster: PREDICTED: similar to caspase 8,... 62 2e-08
UniRef50_Q16PQ5 Cluster: Ecdysone-inducible caspase, putative; n... 62 2e-08
UniRef50_Q0Z855 Cluster: Caspase-2; n=1; Haemaphysalis longicorn... 62 2e-08
UniRef50_Q9IB62 Cluster: Caspase-10; n=5; Xenopus|Rep: Caspase-1... 62 2e-08
UniRef50_Q6E5N8 Cluster: Caspase 8; n=1; Ictalurus punctatus|Rep... 62 2e-08
UniRef50_Q5D0W5 Cluster: Caspase 3C; n=2; Hydra vulgaris|Rep: Ca... 60 7e-08
UniRef50_Q5SVL3 Cluster: Caspase 7, apoptosis-related cysteine p... 60 7e-08
UniRef50_Q8I749 Cluster: Caspase-related protein; n=1; Suberites... 60 9e-08
UniRef50_Q16FR8 Cluster: Caspase-1; n=1; Aedes aegypti|Rep: Casp... 60 9e-08
UniRef50_A3QVU6 Cluster: Initiator caspase; n=3; Culicidae|Rep: ... 60 9e-08
UniRef50_UPI00015B59A2 Cluster: PREDICTED: similar to ecdysone-i... 59 1e-07
UniRef50_A7SXL6 Cluster: Predicted protein; n=1; Nematostella ve... 59 1e-07
UniRef50_Q4FJK5 Cluster: Casp9 protein; n=20; Eutheria|Rep: Casp... 58 2e-07
UniRef50_UPI000065FEF6 Cluster: Homolog of Ictalurus punctatus "... 58 3e-07
UniRef50_Q9IB64 Cluster: Caspase-8; n=1; Xenopus laevis|Rep: Cas... 58 3e-07
UniRef50_A7S9L1 Cluster: Predicted protein; n=1; Nematostella ve... 58 4e-07
UniRef50_Q0PKX0 Cluster: Caspase Xa; n=4; Danio rerio|Rep: Caspa... 57 5e-07
UniRef50_Q4JQQ0 Cluster: Initiator caspase; n=2; Gallus gallus|R... 56 8e-07
UniRef50_Q2HZ04 Cluster: ICE-5; n=3; Bombyx mori|Rep: ICE-5 - Bo... 56 8e-07
UniRef50_P31944 Cluster: Caspase-14 precursor (EC 3.4.22.-) (CAS... 56 8e-07
UniRef50_P55211 Cluster: Caspase-9 precursor (EC 3.4.22.62) (CAS... 56 8e-07
UniRef50_Q9Y1U6 Cluster: Cell death protein CED-3; n=1; Pristion... 56 1e-06
UniRef50_UPI0000F1EBE3 Cluster: PREDICTED: similar to caspase 10... 56 1e-06
UniRef50_P42573 Cluster: Cell death protein 3 precursor (EC 3.4.... 54 3e-06
UniRef50_P42575 Cluster: Caspase-2 precursor (EC 3.4.22.55) (CAS... 54 3e-06
UniRef50_Q3T2L0 Cluster: Caspase-15; n=11; Theria|Rep: Caspase-1... 54 6e-06
UniRef50_Q9Y055 Cluster: Caspase-related protein 2A; n=3; Caenor... 54 6e-06
UniRef50_P55865 Cluster: Caspase-1-A precursor; n=3; Xenopus|Rep... 53 1e-05
UniRef50_Q9GV89 Cluster: Caspase 3A; n=1; Hydra vulgaris|Rep: Ca... 52 1e-05
UniRef50_UPI0000F2DFE8 Cluster: PREDICTED: similar to initiator ... 52 2e-05
UniRef50_UPI0000E45DDA Cluster: PREDICTED: similar to caspase 3;... 52 2e-05
UniRef50_Q504J1 Cluster: Caspase b; n=7; Danio rerio|Rep: Caspas... 51 3e-05
UniRef50_UPI00006A1E20 Cluster: Caspase-9 precursor (EC 3.4.22.6... 45 1e-04
UniRef50_UPI0000E82482 Cluster: PREDICTED: hypothetical protein;... 49 1e-04
UniRef50_UPI0000D56041 Cluster: PREDICTED: similar to CG7486-PB,... 49 1e-04
UniRef50_UPI00015B57F0 Cluster: PREDICTED: similar to GA20532-PA... 48 2e-04
UniRef50_UPI0000E47913 Cluster: PREDICTED: similar to cysteine p... 48 2e-04
UniRef50_Q28GK9 Cluster: Novel protein; n=1; Xenopus tropicalis|... 48 4e-04
UniRef50_UPI0000F1EFFE Cluster: PREDICTED: hypothetical protein;... 47 7e-04
UniRef50_P29466-4 Cluster: Isoform Delta of P29466 ; n=2; Euarch... 46 0.001
UniRef50_P29466-2 Cluster: Isoform Beta of P29466 ; n=11; Theria... 46 0.001
UniRef50_P29466 Cluster: Caspase-1 precursor (EC 3.4.22.36) (CAS... 46 0.001
UniRef50_Q9XYF4 Cluster: Caspase Nc precursor (EC 3.4.22.-) (NED... 46 0.001
UniRef50_UPI0000E4A098 Cluster: PREDICTED: similar to CGI-141 pr... 46 0.002
UniRef50_UPI000051A33A Cluster: PREDICTED: similar to CG6597-PA,... 46 0.002
UniRef50_Q0Z8U7 Cluster: Caspase-8; n=1; Haemaphysalis longicorn... 45 0.002
UniRef50_A2I5C3 Cluster: Putative caspase 3; n=1; Mytilus gallop... 45 0.002
UniRef50_UPI0000661247 Cluster: Homolog of Brachydanio rerio "Ca... 45 0.003
UniRef50_Q4SNC6 Cluster: Chromosome 8 SCAF14543, whole genome sh... 45 0.003
UniRef50_Q9I9L7 Cluster: Caspase; n=2; Danio rerio|Rep: Caspase ... 44 0.005
UniRef50_Q5BLH4 Cluster: Caspase c; n=4; Danio rerio|Rep: Caspas... 44 0.005
UniRef50_Q4S1R8 Cluster: Chromosome undetermined SCAF14764, whol... 43 0.008
UniRef50_UPI0000F2CF2E Cluster: PREDICTED: similar to caspase 12... 43 0.011
UniRef50_Q07BT4 Cluster: Caspase-1; n=2; Percomorpha|Rep: Caspas... 41 0.034
UniRef50_Q178B7 Cluster: Caspase-3; n=2; Aedes aegypti|Rep: Casp... 41 0.045
UniRef50_UPI0000F2CF2D Cluster: PREDICTED: similar to evolutiona... 40 0.059
UniRef50_A6NFM5 Cluster: Uncharacterized protein ENSP00000371619... 40 0.059
UniRef50_P51878 Cluster: Caspase-5 precursor (EC 3.4.22.58) (CAS... 40 0.059
UniRef50_Q7ZXD2 Cluster: MGC53258 protein; n=3; Xenopus|Rep: MGC... 40 0.079
UniRef50_O42284 Cluster: Caspase-1; n=3; Gallus gallus|Rep: Casp... 40 0.079
UniRef50_UPI000155BC01 Cluster: PREDICTED: similar to cellular F... 39 0.14
UniRef50_UPI0000E47F37 Cluster: PREDICTED: similar to caspase-3,... 39 0.18
UniRef50_UPI0000587146 Cluster: PREDICTED: similar to caspase Xa... 38 0.32
UniRef50_Q7QGN0 Cluster: ENSANGP00000018113; n=4; Anopheles gamb... 37 0.55
UniRef50_UPI0000DB7195 Cluster: PREDICTED: similar to caspase 10... 37 0.73
UniRef50_UPI0000D57084 Cluster: PREDICTED: similar to CG8091-PA;... 37 0.73
UniRef50_UPI000065DDFC Cluster: CASP8 and FADD-like apoptosis re... 37 0.73
UniRef50_Q498I3 Cluster: LOC780745 protein; n=6; Xenopus|Rep: LO... 37 0.73
UniRef50_Q5CX96 Cluster: Putative uncharacterized protein; n=4; ... 37 0.73
UniRef50_O15519-8 Cluster: Isoform 8 of O15519 ; n=3; Homo/Pan/G... 36 1.3
UniRef50_Q896Y6 Cluster: Putative uncharacterized protein; n=1; ... 36 1.3
UniRef50_Q7KHK9 Cluster: DREAM; n=2; Sophophora|Rep: DREAM - Dro... 36 1.3
UniRef50_Q5JRU9 Cluster: Caspase 9, apoptosis-related cysteine p... 36 1.3
UniRef50_O15519 Cluster: CASP8 and FADD-like apoptosis regulator... 36 1.3
UniRef50_Q8IRY7 Cluster: Caspase-8 precursor (EC 3.4.22.61) (Dea... 36 1.3
UniRef50_Q03703 Cluster: Uncharacterized protein YML037C; n=2; S... 36 1.7
UniRef50_Q9UTJ8 Cluster: DNA repair protein rad50; n=1; Schizosa... 35 2.2
UniRef50_Q5E9C1 Cluster: Caspase-4 precursor (EC 3.4.22.57) (CAS... 35 2.2
UniRef50_Q74BT1 Cluster: Fibronectin type III domain protein; n=... 34 5.2
UniRef50_A4QWM4 Cluster: Putative uncharacterized protein; n=1; ... 34 5.2
UniRef50_Q4N957 Cluster: Putative uncharacterized protein; n=1; ... 33 9.0
UniRef50_O08736 Cluster: Caspase-12 precursor; n=12; Eutheria|Re... 33 9.0
>UniRef50_O01382 Cluster: Caspase precursor (EC 3.4.22.-) (drICE)
[Contains: Caspase subunit p21; Caspase subunit p12];
n=13; Endopterygota|Rep: Caspase precursor (EC 3.4.22.-)
(drICE) [Contains: Caspase subunit p21; Caspase subunit
p12] - Drosophila melanogaster (Fruit fly)
Length = 339
Score = 158 bits (384), Expect = 1e-37
Identities = 70/107 (65%), Positives = 84/107 (78%), Gaps = 2/107 (1%)
Frame = +1
Query: 499 YVVSKDTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITL--SNTETDGXX 672
Y+ +KDT YK DN+W +FTA+ CP+LAGKPKLFFIQACQGD+LDGG+T+ S TETDG
Sbjct: 174 YIYAKDTQYKLDNIWSFFTANHCPSLAGKPKLFFIQACQGDRLDGGVTMQRSQTETDGDS 233
Query: 673 XXXYRIPIHADFLIVFSTVPGYYSWRNTTRGSWVYAISFVEELXTMG 813
Y+IP+HADFLI +STVPG+YSWRNTTRGSW + S EL G
Sbjct: 234 SMSYKIPVHADFLIAYSTVPGFYSWRNTTRGSW-FMQSLCAELAANG 279
Score = 111 bits (268), Expect = 2e-23
Identities = 49/86 (56%), Positives = 67/86 (77%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
RGMA+IFNHEHFE+ LKSR GTNVD ++L++VL+ L F VTV + R +DI R I+ +
Sbjct: 93 RGMALIFNHEHFEVPTLKSRAGTNVDCENLTRVLKQLDFEVTVYKDCRYKDILRTIEYAA 152
Query: 437 EMDHTDNDCLLVAVLSHGELGMLYPK 514
+H+D+DC+LVA+LSHGE+G +Y K
Sbjct: 153 SQNHSDSDCILVAILSHGEMGYIYAK 178
>UniRef50_UPI0000D55B5F Cluster: PREDICTED: similar to Caspase
precursor (drICE); n=1; Tribolium castaneum|Rep:
PREDICTED: similar to Caspase precursor (drICE) -
Tribolium castaneum
Length = 309
Score = 154 bits (373), Expect = 3e-36
Identities = 69/103 (66%), Positives = 80/103 (77%), Gaps = 1/103 (0%)
Frame = +1
Query: 508 SKDTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDG-XXXXXY 684
++DT YKPD LW YF AD+CP+LAGKPK+FF+QACQGDKLDGG+ LS TETDG Y
Sbjct: 153 ARDTQYKPDLLWSYFAADRCPSLAGKPKIFFLQACQGDKLDGGVILSRTETDGHLEIDSY 212
Query: 685 RIPIHADFLIVFSTVPGYYSWRNTTRGSWVYAISFVEELXTMG 813
RIP ADFL+V+STV GYYSWRNTTRGSW + + EEL G
Sbjct: 213 RIPAQADFLVVYSTVKGYYSWRNTTRGSW-FIQALCEELRNKG 254
Score = 110 bits (264), Expect = 5e-23
Identities = 49/86 (56%), Positives = 65/86 (75%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
RG+A+IFNHE F+IHNLK RTGT+ D +L VLR LGF V V +LR DI R I+Q +
Sbjct: 69 RGLALIFNHEVFDIHNLKPRTGTDQDRKNLEDVLRKLGFEVIVFQDLRYHDIERQIKQAA 128
Query: 437 EMDHTDNDCLLVAVLSHGELGMLYPK 514
+ DHTD+DCL ++VL+HG+ G+LY +
Sbjct: 129 KYDHTDSDCLCISVLTHGDTGILYAR 154
>UniRef50_UPI00015B57EE Cluster: PREDICTED: similar to
ENSANGP00000010319; n=2; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000010319 - Nasonia
vitripennis
Length = 379
Score = 114 bits (275), Expect = 2e-24
Identities = 53/93 (56%), Positives = 64/93 (68%), Gaps = 3/93 (3%)
Frame = +1
Query: 502 VVSKDTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITL---SNTETDGXX 672
+ +KD YK +N+W FTADKC +LAGKPKLFF QAC+GD LDGGI + TETD
Sbjct: 222 ICAKDVVYKLENVWKPFTADKCSSLAGKPKLFFFQACRGDNLDGGIKMMRSGTTETDS-S 280
Query: 673 XXXYRIPIHADFLIVFSTVPGYYSWRNTTRGSW 771
Y+IP +ADFL STV G+YSWRN G+W
Sbjct: 281 SASYQIPTYADFLFAHSTVQGFYSWRNPEEGTW 313
Score = 68.9 bits (161), Expect = 1e-10
Identities = 30/82 (36%), Positives = 51/82 (62%)
Frame = +2
Query: 245 EPQYRGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYI 424
E + RG +IFNHE F+ ++R G++VD+ + + + LGF+V + + + +
Sbjct: 136 EHRNRGKCVIFNHETFDT-GFETREGSSVDARRIEQTFQQLGFTVEICDDYEHSGVMNKL 194
Query: 425 QQISEMDHTDNDCLLVAVLSHG 490
++SE DH+DNDCL + VL+HG
Sbjct: 195 NELSEEDHSDNDCLCIFVLTHG 216
>UniRef50_UPI00015B4D75 Cluster: PREDICTED: similar to CG7788-PA;
n=1; Nasonia vitripennis|Rep: PREDICTED: similar to
CG7788-PA - Nasonia vitripennis
Length = 456
Score = 113 bits (272), Expect = 5e-24
Identities = 50/102 (49%), Positives = 66/102 (64%), Gaps = 2/102 (1%)
Frame = +1
Query: 514 DTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLS--NTETDGXXXXXYR 687
D Y +++W FT+ CP+L GKP+LFFIQAC+GD+ D GI L +E DG +R
Sbjct: 304 DRKYNAESIWSSFTSSNCPSLEGKPRLFFIQACRGDQTDEGIKLQYCRSEPDGHPNLVFR 363
Query: 688 IPIHADFLIVFSTVPGYYSWRNTTRGSWVYAISFVEELXTMG 813
IP H DFLI +ST+PG+YSWRN +GSW + + EL G
Sbjct: 364 IPTHRDFLIAYSTIPGFYSWRNKKQGSW-FVQALCSELDVYG 404
Score = 100 bits (240), Expect = 4e-20
Identities = 43/84 (51%), Positives = 62/84 (73%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
RG+A+IFNHE FE + SRTGTNVD ++L+ L+ GF V H+L + I+ Y+ +++
Sbjct: 218 RGLALIFNHEFFEDDAINSRTGTNVDCENLASTLKSFGFEVRHFHDLTYQCISNYLGEVA 277
Query: 437 EMDHTDNDCLLVAVLSHGELGMLY 508
+MDH+ +DCL+V VLSHG+LG LY
Sbjct: 278 KMDHSQHDCLVVVVLSHGDLGELY 301
>UniRef50_Q98UI8 Cluster: Caspase-3; n=4; Chordata|Rep: Caspase-3 -
Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 282
Score = 104 bits (249), Expect = 3e-21
Identities = 46/86 (53%), Positives = 56/86 (65%)
Frame = +1
Query: 514 DTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIP 693
DT +L F D+CP+L GKPKLFFIQAC+G +LD G+ +T+ RIP
Sbjct: 134 DTSVDLKSLTSLFRGDRCPSLVGKPKLFFIQACRGTELDPGVETDHTDHPDIPDGRERIP 193
Query: 694 IHADFLIVFSTVPGYYSWRNTTRGSW 771
+ ADFL +STVPGYYSWRNT GSW
Sbjct: 194 VEADFLYAYSTVPGYYSWRNTMTGSW 219
Score = 49.2 bits (112), Expect = 1e-04
Identities = 25/84 (29%), Positives = 47/84 (55%), Gaps = 1/84 (1%)
Frame = +2
Query: 260 GMAIIFNHEHFEIHN-LKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
G II N+++F+ + R GT+VD+ ++ V R LG+ V V ++ I + + ++
Sbjct: 48 GHCIIINNKNFDRRTGMNPRNGTDVDAGNVMNVFRKLGYIVKVYNDQTVAQIMQVLTTVA 107
Query: 437 EMDHTDNDCLLVAVLSHGELGMLY 508
DH+ L+ +LSHG+ G+ +
Sbjct: 108 HDDHSRCASLVCVLLSHGDEGVFF 131
>UniRef50_Q7Q1E0 Cluster: ENSANGP00000015118; n=2; Culicidae|Rep:
ENSANGP00000015118 - Anopheles gambiae str. PEST
Length = 294
Score = 99 bits (238), Expect = 7e-20
Identities = 43/90 (47%), Positives = 62/90 (68%)
Frame = +1
Query: 502 VVSKDTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXX 681
V + D Y+ +W +FTAD CP+LAG+PK+F +QAC+G++LD G+ + DG
Sbjct: 146 VYAYDQPYELSLIWSFFTADNCPSLAGRPKIFVVQACRGNQLDHGV---KVQKDG--VAR 200
Query: 682 YRIPIHADFLIVFSTVPGYYSWRNTTRGSW 771
Y IP HADFL ++T+PG+ ++RNTT GSW
Sbjct: 201 YSIPTHADFLFAYATIPGFMAFRNTTEGSW 230
Score = 73.3 bits (172), Expect = 7e-12
Identities = 35/83 (42%), Positives = 51/83 (61%), Gaps = 2/83 (2%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHN--LKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQ 430
RGMA+IF+H + + N L R G+ +D L + L F V V + + E+I I +
Sbjct: 61 RGMALIFSHNKYNVRNVSLPVREGSAIDCKRLKETLELFRFDVKVYPDFKLEEIKSVIGK 120
Query: 431 ISEMDHTDNDCLLVAVLSHGELG 499
+S MDH+D+DC LVA+L+HGE G
Sbjct: 121 VSSMDHSDSDCFLVAILTHGEDG 143
>UniRef50_P55210 Cluster: Caspase-7 precursor (EC 3.4.22.60)
(CASP-7) (ICE-like apoptotic protease 3) (ICE-LAP3)
(Apoptotic protease Mch-3) (CMH-1) [Contains: Caspase-7
subunit p20; Caspase-7 subunit p11]; n=58;
Euteleostomi|Rep: Caspase-7 precursor (EC 3.4.22.60)
(CASP-7) (ICE-like apoptotic protease 3) (ICE-LAP3)
(Apoptotic protease Mch-3) (CMH-1) [Contains: Caspase-7
subunit p20; Caspase-7 subunit p11] - Homo sapiens
(Human)
Length = 303
Score = 96.7 bits (230), Expect = 6e-19
Identities = 51/102 (50%), Positives = 63/102 (61%), Gaps = 3/102 (2%)
Frame = +1
Query: 502 VVSKDTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITL-SNTETDGXXXX 678
+ KD +L +F D+C TL KPKLFFIQAC+G +LD GI S D
Sbjct: 150 IYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANP 209
Query: 679 XYRIPIHADFLIVFSTVPGYYSWRNTTRGSW-VYAI-SFVEE 798
Y+IP+ ADFL +STVPGYYSWR+ RGSW V A+ S +EE
Sbjct: 210 RYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEE 251
Score = 61.3 bits (142), Expect = 3e-08
Identities = 30/86 (34%), Positives = 50/86 (58%), Gaps = 1/86 (1%)
Frame = +2
Query: 260 GMAIIFNHEHFE-IHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
G II N+++F+ + + R GT+ D+++L K R LGF V V ++ + +++ S
Sbjct: 68 GKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKAS 127
Query: 437 EMDHTDNDCLLVAVLSHGELGMLYPK 514
E DHT+ C +LSHGE ++Y K
Sbjct: 128 EEDHTNAACFACILLSHGEENVIYGK 153
>UniRef50_Q5DD62 Cluster: SJCHGC00800 protein; n=3; Schistosoma
japonicum|Rep: SJCHGC00800 protein - Schistosoma
japonicum (Blood fluke)
Length = 288
Score = 93.1 bits (221), Expect = 8e-18
Identities = 38/90 (42%), Positives = 57/90 (63%)
Frame = +1
Query: 502 VVSKDTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXX 681
V + D + + +F D+CP+L GKPKLFF QAC+G D G++ + G
Sbjct: 128 VYASDDEVQTSYIMSFFRGDRCPSLIGKPKLFFFQACRGVSFDKGVSTMVADA-GDDVIV 186
Query: 682 YRIPIHADFLIVFSTVPGYYSWRNTTRGSW 771
++P+ AD L+ +STVPGY++WRN+T+GSW
Sbjct: 187 RKLPVEADILVSYSTVPGYFAWRNSTKGSW 216
Score = 59.3 bits (137), Expect = 1e-07
Identities = 25/86 (29%), Positives = 50/86 (58%), Gaps = 1/86 (1%)
Frame = +2
Query: 254 YRGMAIIFNHEHFEIH-NLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQ 430
YRG ++ N F+ N R GT++D+D + +V R L + VT + N+ + +++ + +
Sbjct: 44 YRGECLLINQRDFDPSTNQSKRNGTDIDADRIERVFRSLNYKVTRILNITKKALDQTLIE 103
Query: 431 ISEMDHTDNDCLLVAVLSHGELGMLY 508
S+ DH+ D + +L+HG+ ++Y
Sbjct: 104 ASQKDHSSYDSFVFVMLTHGDKDVVY 129
>UniRef50_Q17FE3 Cluster: Caspase-1; n=3; Endopterygota|Rep:
Caspase-1 - Aedes aegypti (Yellowfever mosquito)
Length = 293
Score = 92.3 bits (219), Expect = 1e-17
Identities = 44/107 (41%), Positives = 61/107 (57%), Gaps = 5/107 (4%)
Frame = +1
Query: 508 SKDTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLS-----NTETDGXX 672
++D Y D+LW F + CP+L GKPK+FFIQAC+G++ D G+ + +
Sbjct: 126 ARDNKYNVDSLWKNFVGNACPSLIGKPKMFFIQACRGEQFDEGVAYAAKSPKDMVDSRQE 185
Query: 673 XXXYRIPIHADFLIVFSTVPGYYSWRNTTRGSWVYAISFVEELXTMG 813
Y IP AD L+++ST GYYSWRN +GSW + S EL G
Sbjct: 186 QVLYSIPAMADLLVMYSTYDGYYSWRNPRQGSW-FIQSLCTELDENG 231
Score = 75.4 bits (177), Expect = 2e-12
Identities = 33/86 (38%), Positives = 54/86 (62%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
RG+A++F H +F + + R G + D D + L GL F V V +L +++ ++ +S
Sbjct: 44 RGIALVFCHMNFSV--MAKRNGADKDRDDICNTLYGLDFDVRVFDDLSRKEVLDRLKDVS 101
Query: 437 EMDHTDNDCLLVAVLSHGELGMLYPK 514
DH+DNDCL+V ++SHGE G+LY +
Sbjct: 102 REDHSDNDCLVVVMMSHGEQGVLYAR 127
>UniRef50_P55213 Cluster: Caspase-3 precursor (EC 3.4.22.56)
(CASP-3) (Apopain) (Cysteine protease CPP32) (Yama
protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1)
(LICE) (IRP) [Contains: Caspase-3 subunit p17; Caspase-3
subunit p12]; n=32; Euteleostomi|Rep: Caspase-3
precursor (EC 3.4.22.56) (CASP-3) (Apopain) (Cysteine
protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage
activity 1) (SCA-1) (LICE) (IRP) [Contains: Caspase-3
subunit p17; Caspase-3 subunit p12] - Rattus norvegicus
(Rat)
Length = 277
Score = 88.2 bits (209), Expect = 2e-16
Identities = 42/76 (55%), Positives = 51/76 (67%), Gaps = 1/76 (1%)
Frame = +1
Query: 547 YFTADKCPTLAGKPKLFFIQACQGDKLDGGI-TLSNTETDGXXXXXYRIPIHADFLIVFS 723
+F D C +L GKPKLF IQAC+G +LD GI T S T+ D +IP+ ADFL +S
Sbjct: 142 FFRGDYCRSLTGKPKLFIIQACRGTELDCGIETDSGTDDD---MACQKIPVEADFLYAYS 198
Query: 724 TVPGYYSWRNTTRGSW 771
T PGYYSWRN+ GSW
Sbjct: 199 TAPGYYSWRNSRDGSW 214
Score = 52.8 bits (121), Expect = 1e-05
Identities = 24/84 (28%), Positives = 49/84 (58%), Gaps = 1/84 (1%)
Frame = +2
Query: 260 GMAIIFNHEHF-EIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
G+ II N+++F + + +R GT+VD+ +L + L + V ++L E+I + +S
Sbjct: 45 GLCIIINNKNFHKSTGMSARNGTDVDAANLRETFMALKYEVRNKNDLTREEIMELMDSVS 104
Query: 437 EMDHTDNDCLLVAVLSHGELGMLY 508
+ DH+ + +LSHG+ G+++
Sbjct: 105 KEDHSKRSSFVCVILSHGDEGVIF 128
>UniRef50_UPI0000E48555 Cluster: PREDICTED: similar to Lice2
cysteine protease, partial; n=2; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to Lice2 cysteine
protease, partial - Strongylocentrotus purpuratus
Length = 388
Score = 86.2 bits (204), Expect = 9e-16
Identities = 39/75 (52%), Positives = 48/75 (64%), Gaps = 6/75 (8%)
Frame = +1
Query: 565 CPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXX------YRIPIHADFLIVFST 726
CPTL GKPKLFFIQAC+G ++D G+ + E D Y IP+ ADFL+ FS+
Sbjct: 249 CPTLVGKPKLFFIQACRGTQMDHGVRVPAGEGDDEPDAALGQKMFYTIPVEADFLMAFSS 308
Query: 727 VPGYYSWRNTTRGSW 771
PGYYSWR+ GSW
Sbjct: 309 TPGYYSWRSIREGSW 323
Score = 67.3 bits (157), Expect = 5e-10
Identities = 31/104 (29%), Positives = 61/104 (58%), Gaps = 3/104 (2%)
Frame = +2
Query: 257 RGMAIIFNHEHFE-IHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQI 433
RG A+I N F+ + + +R GT+ D + L +V LGF +L + + ++++
Sbjct: 145 RGKAVIVNQTRFDPMTGMSNREGTDPDIEGLDRVFSNLGFRTEAHSDLTIAEFRKLLKEL 204
Query: 434 SEMDHTDNDCLLVAVLSHGELGMLYPK--TLIINQIICGITSLL 559
S D +++DCLL +SHGE G+LY + T+ +++++C + ++
Sbjct: 205 SIEDFSNDDCLLFIAMSHGEEGVLYCRDGTVAVDELVCRLKGIM 248
>UniRef50_Q7Q802 Cluster: ENSANGP00000021365; n=4; Cellia|Rep:
ENSANGP00000021365 - Anopheles gambiae str. PEST
Length = 296
Score = 83.8 bits (198), Expect = 5e-15
Identities = 40/96 (41%), Positives = 53/96 (55%), Gaps = 2/96 (2%)
Frame = +1
Query: 514 DTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLS--NTETDGXXXXXYR 687
D Y D LW F + C TL GKPKLFF+QAC+G D G+ L + ++D Y
Sbjct: 141 DGPYSVDKLWESFMGNACTTLLGKPKLFFVQACRGSTFDKGVKLGCRDLDSDHFSSHKYV 200
Query: 688 IPIHADFLIVFSTVPGYYSWRNTTRGSWVYAISFVE 795
IP AD L+++S+ G+ SWR+ GSW VE
Sbjct: 201 IPTTADLLVMYSSYKGHVSWRSPRGGSWFIQALCVE 236
Score = 72.9 bits (171), Expect = 9e-12
Identities = 35/84 (41%), Positives = 55/84 (65%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
RGMAII NHE+FE+ + R GTN D D+ + VL + F V V ++L +++ + ++
Sbjct: 57 RGMAIILNHENFEL--MSKREGTNRDRDAATAVLTSMQFDVRVYNDLGRDELFCVLLALA 114
Query: 437 EMDHTDNDCLLVAVLSHGELGMLY 508
DH+D DCLLV +++HG+ +LY
Sbjct: 115 SEDHSDCDCLLVMLMTHGDDDVLY 138
>UniRef50_UPI0000519DFF Cluster: PREDICTED: similar to Caspase
precursor (drICE); n=1; Apis mellifera|Rep: PREDICTED:
similar to Caspase precursor (drICE) - Apis mellifera
Length = 280
Score = 82.6 bits (195), Expect = 1e-14
Identities = 42/91 (46%), Positives = 56/91 (61%), Gaps = 1/91 (1%)
Frame = +1
Query: 502 VVSKDTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGIT-LSNTETDGXXXX 678
V + D Y +W F +D C +LAGKPKLFFIQAC+G D GI S ++D
Sbjct: 126 VSAYDISYPVQMIWQPFNSDNCISLAGKPKLFFIQACRGVTSDSGIQGRSGIDSD---EM 182
Query: 679 XYRIPIHADFLIVFSTVPGYYSWRNTTRGSW 771
Y +P+ ADFL +ST+ G YS+R+T +GSW
Sbjct: 183 TYVLPMTADFLYAYSTMEGCYSFRDTNKGSW 213
Score = 67.3 bits (157), Expect = 5e-10
Identities = 29/81 (35%), Positives = 45/81 (55%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
RG +IFNHE FE + R GTN D ++++ LGF V + +L+ I I +
Sbjct: 43 RGKCVIFNHEKFENNRESQRNGTNYDEKAINETFSTLGFEVKIYKDLKFNKIIEVITSLQ 102
Query: 437 EMDHTDNDCLLVAVLSHGELG 499
+H D DC+ +L+HG++G
Sbjct: 103 NENHDDCDCICFFILTHGKIG 123
>UniRef50_UPI0000E49D20 Cluster: PREDICTED: hypothetical protein;
n=1; Strongylocentrotus purpuratus|Rep: PREDICTED:
hypothetical protein - Strongylocentrotus purpuratus
Length = 329
Score = 79.8 bits (188), Expect = 8e-14
Identities = 37/87 (42%), Positives = 55/87 (63%), Gaps = 1/87 (1%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHN-LKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQI 433
RGMA+IFNHE+F+ + R GTN D ++L L LGF V V + A ++ R ++
Sbjct: 81 RGMAVIFNHENFDWKTGMNQRVGTNHDVENLKLHLGRLGFKVLVFQDASASELRRNLELA 140
Query: 434 SEMDHTDNDCLLVAVLSHGELGMLYPK 514
S+ DHTD+DC + L+HG+ G+LY +
Sbjct: 141 SKADHTDSDCFMCVFLTHGDDGILYAR 167
Score = 69.7 bits (163), Expect = 8e-11
Identities = 39/99 (39%), Positives = 52/99 (52%), Gaps = 11/99 (11%)
Frame = +1
Query: 508 SKDTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXY- 684
++D+ L+ +F +KCPTL GKPKLF IQAC+GD+ + G+ TD
Sbjct: 166 ARDSTLDLQELFEFFRGEKCPTLIGKPKLFLIQACRGDRHEIGVDPPVDVTDSAAPEDEW 225
Query: 685 ----------RIPIHADFLIVFSTVPGYYSWRNTTRGSW 771
IP AD L+ +S V GYYS R+T GSW
Sbjct: 226 VTVTDSGTRPTIPAAADMLLSYSVVQGYYSHRDTAFGSW 264
>UniRef50_Q8JIS8 Cluster: Caspase 3A; n=3; Euteleostomi|Rep: Caspase
3A - Oryzias latipes (Medaka fish) (Japanese ricefish)
Length = 290
Score = 79.8 bits (188), Expect = 8e-14
Identities = 38/69 (55%), Positives = 44/69 (63%)
Frame = +1
Query: 565 CPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFLIVFSTVPGYYS 744
C +L GKPKLFFIQAC+G D GI E D +IP+ ADFL +STV GYYS
Sbjct: 161 CLSLVGKPKLFFIQACRGMLFDEGI-----EHDAKDDTSEKIPLEADFLFAYSTVSGYYS 215
Query: 745 WRNTTRGSW 771
WR+T GSW
Sbjct: 216 WRSTANGSW 224
Score = 47.2 bits (107), Expect = 5e-04
Identities = 22/84 (26%), Positives = 46/84 (54%), Gaps = 1/84 (1%)
Frame = +2
Query: 260 GMAIIFNHEHFEIHN-LKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
G+ +I N+++F + + R GT+ D+ + K LG+ + + ++ + + + +Q+S
Sbjct: 58 GICLIINNKNFHKDSGMGPRNGTDNDAAAAWKSFMKLGYEIQMYNDQTVDQMKKLFRQMS 117
Query: 437 EMDHTDNDCLLVAVLSHGELGMLY 508
DH+ +LSHGE G++Y
Sbjct: 118 NQDHSKFASFACVILSHGEEGVIY 141
>UniRef50_Q7Q803 Cluster: ENSANGP00000021367; n=6; Anopheles gambiae
str. PEST|Rep: ENSANGP00000021367 - Anopheles gambiae
str. PEST
Length = 320
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/127 (37%), Positives = 60/127 (47%), Gaps = 22/127 (17%)
Frame = +1
Query: 508 SKDTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETD-------- 663
+KD + D LW F D CP+L GKPKLFFIQAC+G D G+ S T
Sbjct: 146 AKDGTFNVDRLWENFIGDSCPSLLGKPKLFFIQACRGSSFDTGVHFSQCMTQVAKTVVPY 205
Query: 664 --------------GXXXXXYRIPIHADFLIVFSTVPGYYSWRNTTRGSWVYAISFVEEL 801
Y IP AD L+++ST G+YSWRN + GSW + + +EL
Sbjct: 206 AMRELPQPSIVPGCPKSSIQYAIPSMADLLVMYSTYKGHYSWRNPSTGSW-FIRALCDEL 264
Query: 802 XTMGPPK 822
G K
Sbjct: 265 REHGNSK 271
Score = 69.7 bits (163), Expect = 8e-11
Identities = 33/86 (38%), Positives = 55/86 (63%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
RG+A +FNH F +H R GT+ D D++ +VL L F V V +L ++I + + ++
Sbjct: 64 RGVAAVFNHRKF-LH-ASERKGTDADCDNIRQVLIYLQFEVRVYDDLTRKEIKQVLDDLA 121
Query: 437 EMDHTDNDCLLVAVLSHGELGMLYPK 514
E DH ++DCLLV +++HG+ +L+ K
Sbjct: 122 EEDHKNSDCLLVVIMTHGDDDVLHAK 147
>UniRef50_Q8I6Y2 Cluster: Caspase-3; n=2; Geodia cydonium|Rep:
Caspase-3 - Geodia cydonium (Sponge)
Length = 426
Score = 63.3 bits (147), Expect = 7e-09
Identities = 30/84 (35%), Positives = 50/84 (59%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
RGMA+I N+ +F +K R GT+ D+++L + LG + NL + + R + ++
Sbjct: 157 RGMALIINNRNFTC-GMKERVGTDKDAENLYGLFNWLGMATIRKDNLTGKAMTREFEDLA 215
Query: 437 EMDHTDNDCLLVAVLSHGELGMLY 508
DH+ DC++VA+L+HG G LY
Sbjct: 216 RRDHSAYDCVVVAILTHGISGRLY 239
Score = 53.2 bits (122), Expect(2) = 1e-13
Identities = 23/62 (37%), Positives = 36/62 (58%)
Frame = +1
Query: 643 LSNTETDGXXXXXYRIPIHADFLIVFSTVPGYYSWRNTTRGSWVYAISFVEELXTMGPPK 822
L ETDG +P ADF++ ++TVPGY SWRN+ GSW + +FV+ + + +
Sbjct: 317 LDADETDGGGYSREALPTEADFVLAYATVPGYVSWRNSEYGSW-FIKAFVDTMRDLASKE 375
Query: 823 XY 828
+
Sbjct: 376 HF 377
Score = 46.0 bits (104), Expect(2) = 1e-13
Identities = 19/45 (42%), Positives = 29/45 (64%)
Frame = +1
Query: 532 DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDG 666
++L YF P+L GKPK+F +QAC+G K D G+ +T+ +G
Sbjct: 249 EDLTKYFDGVNRPSLIGKPKVFVVQACRGGKFDYGVESESTDGEG 293
>UniRef50_Q92851-2 Cluster: Isoform B of Q92851 ; n=9; Mammalia|Rep:
Isoform B of Q92851 - Homo sapiens (Human)
Length = 479
Score = 76.6 bits (180), Expect = 7e-13
Identities = 47/120 (39%), Positives = 62/120 (51%), Gaps = 5/120 (4%)
Frame = +1
Query: 472 CCVESWRIRYVVSKDTHYKP-DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLS 648
C + R V S D P + +FTA +CP LA KPKLFFIQACQG+++ +++
Sbjct: 311 CILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIE 370
Query: 649 ----NTETDGXXXXXYRIPIHADFLIVFSTVPGYYSWRNTTRGSWVYAISFVEELXTMGP 816
N E IP ADFL+ +TVPGY S+R+ GSW Y S L + P
Sbjct: 371 ADALNPE-QAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSW-YIQSLCNHLKKLVP 428
Score = 61.7 bits (143), Expect = 2e-08
Identities = 36/105 (34%), Positives = 60/105 (57%), Gaps = 4/105 (3%)
Frame = +2
Query: 254 YRGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQ-Q 430
+RG+ +I N+ F +LK R GT+ D++ LS V + LGF+V + +N+ ++ +Q Q
Sbjct: 239 HRGLCVIVNNHSFT--SLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQ 296
Query: 431 ISEMDHTDNDCLLVAVLSHGELGMLY--PKTLI-INQIICGITSL 556
H D DC + +L+HG G +Y + LI I +I+ T+L
Sbjct: 297 KCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTAL 341
>UniRef50_Q2TM51 Cluster: Caspase; n=3; Penaeidae|Rep: Caspase -
Fenneropenaeus merguiensis (Banana prawn) (Penaeus
merguiensis)
Length = 320
Score = 76.6 bits (180), Expect = 7e-13
Identities = 37/98 (37%), Positives = 60/98 (61%), Gaps = 7/98 (7%)
Frame = +1
Query: 493 IRYVVSKDTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSN------T 654
+ +V +KD LW FTA++C +LAGKPKL+FIQAC+G +D G+ +S
Sbjct: 153 MEFVWAKDDKIPTKELWINFTAERCASLAGKPKLYFIQACRGLDVDKGVNMSRAVRGMAV 212
Query: 655 ETDG-XXXXXYRIPIHADFLIVFSTVPGYYSWRNTTRG 765
+TD Y IP+HAD L+++++ PG+ ++ + +G
Sbjct: 213 QTDNIGSTEEYVIPVHADQLVMWASYPGFPAFTSNRKG 250
Score = 62.5 bits (145), Expect = 1e-08
Identities = 26/80 (32%), Positives = 47/80 (58%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
RG A+IF H F+ +L+ R D++ S + LGF V NL +++ + + ++S
Sbjct: 68 RGAALIFAHSEFKNESLRPRPSAAHDAEIASDAFKALGFLPEVFSNLTKDELEKTLHEVS 127
Query: 437 EMDHTDNDCLLVAVLSHGEL 496
+ DH+ +D L++ +SHGE+
Sbjct: 128 KRDHSGSDALVIVFMSHGEV 147
>UniRef50_Q6KF63 Cluster: Caspase 10; n=3; Catarrhini|Rep: Caspase
10 - Homo sapiens (Human)
Length = 455
Score = 76.6 bits (180), Expect = 7e-13
Identities = 47/120 (39%), Positives = 62/120 (51%), Gaps = 5/120 (4%)
Frame = +1
Query: 472 CCVESWRIRYVVSKDTHYKP-DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLS 648
C + R V S D P + +FTA +CP LA KPKLFFIQACQG+++ +++
Sbjct: 287 CILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIE 346
Query: 649 ----NTETDGXXXXXYRIPIHADFLIVFSTVPGYYSWRNTTRGSWVYAISFVEELXTMGP 816
N E IP ADFL+ +TVPGY S+R+ GSW Y S L + P
Sbjct: 347 ADALNPE-QAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSW-YIQSLCNHLKKLVP 404
Score = 41.9 bits (94), Expect = 0.019
Identities = 25/78 (32%), Positives = 43/78 (55%), Gaps = 4/78 (5%)
Frame = +2
Query: 335 SDSLSKVLRGLGFSVTVLHNLRAEDINRYIQ-QISEMDHTDNDCLLVAVLSHGELGMLY- 508
++ LS V + LGF+V + +N+ ++ +Q Q H D DC + +L+HG G +Y
Sbjct: 240 NEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYS 299
Query: 509 -PKTLI-INQIICGITSL 556
+ LI I +I+ T+L
Sbjct: 300 SDEALIPIREIMSHFTAL 317
>UniRef50_Q92851 Cluster: Caspase-10 precursor (EC 3.4.22.63)
(CASP-10) (ICE-like apoptotic protease 4) (Apoptotic
protease Mch-4) (FAS-associated death domain protein
interleukin-1B-converting enzyme 2) (FLICE2) [Contains:
Caspase-10 subunit p23/17; Caspase-10 subunit p12]; n=9;
Eutheria|Rep: Caspase-10 precursor (EC 3.4.22.63)
(CASP-10) (ICE-like apoptotic protease 4) (Apoptotic
protease Mch-4) (FAS-associated death domain protein
interleukin-1B-converting enzyme 2) (FLICE2) [Contains:
Caspase-10 subunit p23/17; Caspase-10 subunit p12] -
Homo sapiens (Human)
Length = 521
Score = 76.6 bits (180), Expect = 7e-13
Identities = 47/120 (39%), Positives = 62/120 (51%), Gaps = 5/120 (4%)
Frame = +1
Query: 472 CCVESWRIRYVVSKDTHYKP-DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLS 648
C + R V S D P + +FTA +CP LA KPKLFFIQACQG+++ +++
Sbjct: 354 CILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIE 413
Query: 649 ----NTETDGXXXXXYRIPIHADFLIVFSTVPGYYSWRNTTRGSWVYAISFVEELXTMGP 816
N E IP ADFL+ +TVPGY S+R+ GSW Y S L + P
Sbjct: 414 ADALNPE-QAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSW-YIQSLCNHLKKLVP 471
Score = 61.7 bits (143), Expect = 2e-08
Identities = 36/105 (34%), Positives = 60/105 (57%), Gaps = 4/105 (3%)
Frame = +2
Query: 254 YRGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQ-Q 430
+RG+ +I N+ F +LK R GT+ D++ LS V + LGF+V + +N+ ++ +Q Q
Sbjct: 282 HRGLCVIVNNHSFT--SLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQ 339
Query: 431 ISEMDHTDNDCLLVAVLSHGELGMLY--PKTLI-INQIICGITSL 556
H D DC + +L+HG G +Y + LI I +I+ T+L
Sbjct: 340 KCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTAL 384
>UniRef50_A1L2P4 Cluster: LOC100036910 protein; n=1; Xenopus
laevis|Rep: LOC100036910 protein - Xenopus laevis
(African clawed frog)
Length = 235
Score = 74.1 bits (174), Expect = 4e-12
Identities = 35/67 (52%), Positives = 43/67 (64%)
Frame = +1
Query: 535 NLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFLI 714
NL F D+C TL GKPK+FFIQAC+G +LD GI + G +RIP+ ADFL
Sbjct: 149 NLTDLFRGDRCKTLVGKPKIFFIQACRGTELDSGIETDSGSEPG--EETHRIPVEADFLY 206
Query: 715 VFSTVPG 735
+STVPG
Sbjct: 207 AYSTVPG 213
Score = 63.7 bits (148), Expect = 6e-09
Identities = 30/84 (35%), Positives = 52/84 (61%), Gaps = 1/84 (1%)
Frame = +2
Query: 260 GMAIIFNHEHFEIH-NLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
G+ +I N+++F ++ R GT+VD+ L + LG+ V VL++ R DI +++++S
Sbjct: 56 GVCLIINNKNFHSSTSMTVRNGTDVDARRLHETFTSLGYKVKVLNDQRCNDIFGHLKKMS 115
Query: 437 EMDHTDNDCLLVAVLSHGELGMLY 508
E DH+ A+LSHGE G++Y
Sbjct: 116 EEDHSKRSSFACAILSHGEDGLIY 139
>UniRef50_P55212 Cluster: Caspase-6 precursor (EC 3.4.22.59)
(CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6
subunit p18; Caspase-6 subunit p11]; n=35;
Euteleostomi|Rep: Caspase-6 precursor (EC 3.4.22.59)
(CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6
subunit p18; Caspase-6 subunit p11] - Homo sapiens
(Human)
Length = 293
Score = 74.1 bits (174), Expect = 4e-12
Identities = 36/85 (42%), Positives = 51/85 (60%), Gaps = 1/85 (1%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIH-NLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQI 433
RG+A+IFNHE F H L R GT D D+L++ LGF V ++L+AE++ I ++
Sbjct: 44 RGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEV 103
Query: 434 SEMDHTDNDCLLVAVLSHGELGMLY 508
S + H D DC + LSHGE +Y
Sbjct: 104 STVSHADADCFVCVFLSHGEGNHIY 128
Score = 66.1 bits (154), Expect = 1e-09
Identities = 40/116 (34%), Positives = 54/116 (46%), Gaps = 11/116 (9%)
Frame = +1
Query: 499 YVVSKDTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGI-----------TL 645
++ + D + L F DKC +L GKPK+F IQAC+G++ D + L
Sbjct: 126 HIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKL 185
Query: 646 SNTETDGXXXXXYRIPIHADFLIVFSTVPGYYSWRNTTRGSWVYAISFVEELXTMG 813
T+ Y +P ADFL+ +S GYYS R T GSW Y E L G
Sbjct: 186 DTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSW-YIQDLCEMLGKYG 240
>UniRef50_Q9NHF9 Cluster: Caspase 6-like protein BG2; n=3;
Sophophora|Rep: Caspase 6-like protein BG2 - Drosophila
melanogaster (Fruit fly)
Length = 308
Score = 73.7 bits (173), Expect = 5e-12
Identities = 32/87 (36%), Positives = 52/87 (59%)
Frame = +2
Query: 260 GMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQISE 439
G+A+I NH+ ++ K R GT D D + L+G GF V +L +IN +++++
Sbjct: 56 GIALILNHK--DVKGQKQRVGTERDRDDMEATLQGFGFDVRTFDDLTFSEINDTLKEVAR 113
Query: 440 MDHTDNDCLLVAVLSHGELGMLYPKTL 520
DH+ NDC ++AV+SHG G +Y K +
Sbjct: 114 EDHSQNDCFVLAVMSHGTEGKVYAKDM 140
Score = 70.9 bits (166), Expect = 4e-11
Identities = 38/100 (38%), Positives = 49/100 (49%), Gaps = 10/100 (10%)
Frame = +1
Query: 502 VVSKDTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSN---------- 651
V +KD Y + LW F D C TL KPKLFFIQAC+G L+ + S+
Sbjct: 135 VYAKDMSYPVERLWNPFLGDNCKTLKNKPKLFFIQACRGANLEKAVEFSSFAVMTRELVP 194
Query: 652 TETDGXXXXXYRIPIHADFLIVFSTVPGYYSWRNTTRGSW 771
Y IP AD L+ +ST ++S+RN GSW
Sbjct: 195 EPAAAVQPITYAIPSTADILVFYSTFDKFFSFRNVDDGSW 234
>UniRef50_Q3HL92 Cluster: Caspase-like protein; n=6; Eumetazoa|Rep:
Caspase-like protein - Aiptasia pallida (Sea anemone)
Length = 415
Score = 73.3 bits (172), Expect = 7e-12
Identities = 33/70 (47%), Positives = 42/70 (60%)
Frame = +1
Query: 562 KCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFLIVFSTVPGYY 741
K L GKPK+F QACQG + G+ ++ +IP+ ADFL +STVPGYY
Sbjct: 279 KGTNLVGKPKIFIFQACQGHEYMDGVDATDAPP---ADKRVQIPVEADFLYAYSTVPGYY 335
Query: 742 SWRNTTRGSW 771
SWRN+ GSW
Sbjct: 336 SWRNSVNGSW 345
Score = 62.5 bits (145), Expect = 1e-08
Identities = 31/88 (35%), Positives = 55/88 (62%), Gaps = 4/88 (4%)
Frame = +2
Query: 257 RGMAIIFNHEHF----EIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYI 424
RG+A+I N++ F +H R GT+VD D+L KV + LGF+ V ++ +I +
Sbjct: 177 RGVAVIINNKSFLPASGMHRYP-RNGTDVDRDALDKVFQKLGFNTLVYNDQSVYEIQKIF 235
Query: 425 QQISEMDHTDNDCLLVAVLSHGELGMLY 508
+ ++ D++ + L+V++L+HGE G+LY
Sbjct: 236 KSLAARDYSKENALIVSILTHGEEGILY 263
>UniRef50_Q7QKT2 Cluster: ENSANGP00000015505; n=3; Anopheles gambiae
str. PEST|Rep: ENSANGP00000015505 - Anopheles gambiae
str. PEST
Length = 263
Score = 72.5 bits (170), Expect = 1e-11
Identities = 37/98 (37%), Positives = 56/98 (57%), Gaps = 2/98 (2%)
Frame = +1
Query: 514 DTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDG--XXXXXYR 687
D + D LW F +KCP+L GKPKL FIQ+C+G KLD G +++ + +
Sbjct: 113 DDYLHIDELWTNFVGNKCPSLIGKPKLVFIQSCRGGKLDYGASIATADARPGLEEPVDVK 172
Query: 688 IPIHADFLIVFSTVPGYYSWRNTTRGSWVYAISFVEEL 801
IP++AD L+++S+ + S R GSW + SF + L
Sbjct: 173 IPMYADLLVMYSSFEHHSSIRCRNEGSW-FIQSFCQVL 209
Score = 52.4 bits (120), Expect = 1e-05
Identities = 23/65 (35%), Positives = 39/65 (60%)
Frame = +2
Query: 296 IHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQISEMDHTDNDCLLVA 475
I+N + R G+ D +L VL L F V +L + +I ++++S+ DHT+NDCL +
Sbjct: 40 INNNRDRKGSEKDVKALQAVLSHLQFDVRLLSDKTTVEIRHALKEVSKEDHTNNDCLAII 99
Query: 476 VLSHG 490
++HG
Sbjct: 100 AMAHG 104
>UniRef50_UPI0000F21D96 Cluster: PREDICTED: hypothetical protein,
partial; n=1; Danio rerio|Rep: PREDICTED: hypothetical
protein, partial - Danio rerio
Length = 170
Score = 72.1 bits (169), Expect = 2e-11
Identities = 34/86 (39%), Positives = 50/86 (58%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
RGMA+IFN + F + LK+R GT+ D DSL L F V ++ + + R I++++
Sbjct: 25 RGMALIFNQKDFSLLGLKTRKGTDKDRDSLVSRFEELDFEVKAYNDYSRDKVLREIKEVA 84
Query: 437 EMDHTDNDCLLVAVLSHGELGMLYPK 514
DH D DC + LSHGE G +Y +
Sbjct: 85 AADHVDADCFVCIFLSHGEDGHVYAR 110
Score = 46.8 bits (106), Expect = 7e-04
Identities = 21/53 (39%), Positives = 30/53 (56%)
Frame = +1
Query: 499 YVVSKDTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTE 657
+V ++D K + F DKC +L GKPK+F QAC+GDK D + + E
Sbjct: 106 HVYARDKKIKIPEITDLFKGDKCRSLVGKPKIFIWQACRGDKKDDPVAPMSAE 158
>UniRef50_A7SPA7 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 242
Score = 72.1 bits (169), Expect = 2e-11
Identities = 39/86 (45%), Positives = 49/86 (56%), Gaps = 2/86 (2%)
Frame = +1
Query: 550 FTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNT-ETDGXXXXXYRI-PIHADFLIVFS 723
F + CPTLA KPKLFFIQAC+G D GI T + D P + FL+ ++
Sbjct: 110 FKGNACPTLAHKPKLFFIQACRGQDFDRGIQADATRDMDASDAVRQNAEPNESHFLLGYA 169
Query: 724 TVPGYYSWRNTTRGSWVYAISFVEEL 801
T PGY SWR+ GSW ISF+ E+
Sbjct: 170 TPPGYVSWRSQVHGSWY--ISFLCEV 193
Score = 58.4 bits (135), Expect = 2e-07
Identities = 25/84 (29%), Positives = 46/84 (54%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
RG+ +I +++HF+ L+ R G D ++L + L F V + + A ++ ++ S
Sbjct: 11 RGICLIISNQHFDKPELRKRDGNEQDVENLKRTFENLHFVVEIRQDKTASEMYTIAREFS 70
Query: 437 EMDHTDNDCLLVAVLSHGELGMLY 508
+DH+ D + +LSHG LG +Y
Sbjct: 71 SIDHSAYDLFVCCILSHGMLGSIY 94
>UniRef50_Q4RG79 Cluster: Chromosome 2 SCAF15106, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 2 SCAF15106, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 242
Score = 71.3 bits (167), Expect = 3e-11
Identities = 41/98 (41%), Positives = 49/98 (50%), Gaps = 24/98 (24%)
Frame = +1
Query: 550 FTADKCPTLAGKPKLFFIQ--------------------ACQGDKLDGGITLS----NTE 657
F D C +L GKPKLFFIQ AC+G + D GI N
Sbjct: 83 FRGDMCKSLVGKPKLFFIQFSAETATQDHNEMSSHLLHQACRGSEFDDGIQTDSGPPNDT 142
Query: 658 TDGXXXXXYRIPIHADFLIVFSTVPGYYSWRNTTRGSW 771
+ ++IP+ ADFL +STVPGYYSWRN RGSW
Sbjct: 143 METDANPRHKIPVEADFLFAYSTVPGYYSWRNPGRGSW 180
Score = 58.4 bits (135), Expect = 2e-07
Identities = 25/65 (38%), Positives = 39/65 (60%)
Frame = +2
Query: 314 RTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQISEMDHTDNDCLLVAVLSHGE 493
R GT+ D+ L K + LGF V + ++ E + +++ SE DH+D+ C +LSHGE
Sbjct: 4 RNGTDRDAGELYKCFKSLGFDVFIYNDQTCEKMEHLLREASEEDHSDSSCFACILLSHGE 63
Query: 494 LGMLY 508
GM+Y
Sbjct: 64 EGMIY 68
>UniRef50_UPI0000F2097E Cluster: PREDICTED: hypothetical protein;
n=3; Danio rerio|Rep: PREDICTED: hypothetical protein -
Danio rerio
Length = 266
Score = 70.5 bits (165), Expect = 5e-11
Identities = 34/90 (37%), Positives = 49/90 (54%), Gaps = 1/90 (1%)
Frame = +1
Query: 502 VVSKDTHYKP-DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXX 678
++ D + P L T+D CP+L KPK+FF+QAC+G + D G+ + E
Sbjct: 109 ILGSDERWIPVKTLTSLLTSDLCPSLRDKPKIFFLQACRGVEYDPGVEADSVEASEDFFG 168
Query: 679 XYRIPIHADFLIVFSTVPGYYSWRNTTRGS 768
+P DFL +STV GY++WRN GS
Sbjct: 169 ISDVP-ELDFLCCYSTVEGYFAWRNPETGS 197
Score = 66.9 bits (156), Expect = 6e-10
Identities = 32/82 (39%), Positives = 46/82 (56%)
Frame = +2
Query: 260 GMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQISE 439
G +I ++EHF R G +VD LS + LGF V V +NL A + ++ +SE
Sbjct: 28 GKCLIISNEHFPDSPRLYRKGNSVDERRLSSTFKSLGFHVKVENNLSANQMIDALRTVSE 87
Query: 440 MDHTDNDCLLVAVLSHGELGML 505
DHTDN C + ++SHGE G +
Sbjct: 88 EDHTDNSCFVCVLMSHGEEGTI 109
>UniRef50_A7S4V9 Cluster: Predicted protein; n=2; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 358
Score = 70.1 bits (164), Expect = 6e-11
Identities = 32/74 (43%), Positives = 43/74 (58%)
Frame = +1
Query: 550 FTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFLIVFSTV 729
F + L GKPKLFF+QAC+G D G + ++ +P ADFLI ++TV
Sbjct: 226 FNGYQAKDLIGKPKLFFLQACRGGDFDHGARMEQIDSPTDKSS---LPSEADFLIAYATV 282
Query: 730 PGYYSWRNTTRGSW 771
PGY SWR+ +GSW
Sbjct: 283 PGYVSWRHQEKGSW 296
>UniRef50_Q14790 Cluster: Caspase-8 precursor (EC 3.4.22.61)
(CASP-8) (ICE-like apoptotic protease 5)
(MORT1-associated CED-3 homolog) (MACH) (FADD-homologous
ICE/CED-3-like protease) (FADD-like ICE) (FLICE)
(Apoptotic cysteine protease) (Apoptotic protease Mch-5)
(CAP4) [Contains: Caspase-8 subunit p18; Caspase-8
subunit p10]; n=35; Amniota|Rep: Caspase-8 precursor (EC
3.4.22.61) (CASP-8) (ICE-like apoptotic protease 5)
(MORT1-associated CED-3 homolog) (MACH) (FADD-homologous
ICE/CED-3-like protease) (FADD-like ICE) (FLICE)
(Apoptotic cysteine protease) (Apoptotic protease Mch-5)
(CAP4) [Contains: Caspase-8 subunit p18; Caspase-8
subunit p10] - Homo sapiens (Human)
Length = 479
Score = 68.9 bits (161), Expect = 1e-10
Identities = 47/124 (37%), Positives = 59/124 (47%), Gaps = 9/124 (7%)
Frame = +1
Query: 472 CCVESWRIRYVV-SKDTHYKPD-NLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITL 645
CC+ S + ++ D P L FT KCP+LAGKPK+FFIQACQGD GI +
Sbjct: 312 CCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPV 371
Query: 646 SN-------TETDGXXXXXYRIPIHADFLIVFSTVPGYYSWRNTTRGSWVYAISFVEELX 804
E D IP ADFL+ +TV S+RN G+W Y S + L
Sbjct: 372 ETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW-YIQSLCQSLR 430
Query: 805 TMGP 816
P
Sbjct: 431 ERCP 434
Score = 56.0 bits (129), Expect = 1e-06
Identities = 26/92 (28%), Positives = 50/92 (54%), Gaps = 8/92 (8%)
Frame = +2
Query: 257 RGMAIIFNHEHF--------EIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDI 412
RG +I N+ +F ++H+++ R GT++D+ +L+ L F + + E I
Sbjct: 233 RGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQI 292
Query: 413 NRYIQQISEMDHTDNDCLLVAVLSHGELGMLY 508
++ MDH++ DC + +LSHG+ G++Y
Sbjct: 293 YEILKIYQLMDHSNMDCFICCILSHGDKGIIY 324
>UniRef50_Q4V923 Cluster: Zgc:101776 protein; n=8;
Clupeocephala|Rep: Zgc:101776 protein - Danio rerio
(Zebrafish) (Brachydanio rerio)
Length = 436
Score = 67.7 bits (158), Expect = 3e-10
Identities = 31/78 (39%), Positives = 48/78 (61%), Gaps = 1/78 (1%)
Frame = +2
Query: 260 GMAIIFNHEHFE-IHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
G+ +I N+ +FE L R G+N+D D L K +GL F VTV NL+++ I + ++
Sbjct: 172 GVCLIINNINFEKASELNDRKGSNIDCDKLEKRFKGLNFEVTVKRNLKSKRIRHEMASLA 231
Query: 437 EMDHTDNDCLLVAVLSHG 490
+ DH+ DC +V +LSHG
Sbjct: 232 KKDHSTYDCCVVIILSHG 249
Score = 54.8 bits (126), Expect = 3e-06
Identities = 36/101 (35%), Positives = 45/101 (44%), Gaps = 26/101 (25%)
Frame = +1
Query: 547 YFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETD----GXXXXXYRIPIHA---- 702
Y CP+L GKPKLFFIQAC G + D G +S + G IP+ +
Sbjct: 277 YLNGQNCPSLQGKPKLFFIQACGGGEKDIGFEVSPDDVQPCIGGIDDEMDAIPMSSSSDS 336
Query: 703 ------------------DFLIVFSTVPGYYSWRNTTRGSW 771
D L+ +ST PGY SWR+T GSW
Sbjct: 337 LSTASDELDARASLPTPSDILVSYSTFPGYVSWRDTEAGSW 377
>UniRef50_Q0WYJ4 Cluster: Caspase 10; n=4; Percomorpha|Rep: Caspase
10 - Paralichthys olivaceus (Japanese flounder)
Length = 494
Score = 67.3 bits (157), Expect = 5e-10
Identities = 42/104 (40%), Positives = 54/104 (51%), Gaps = 7/104 (6%)
Frame = +1
Query: 526 KPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXY------- 684
K ++L A CPTLA KPKLFFIQACQG K + + E DG
Sbjct: 340 KINDLMEPLNAHNCPTLAQKPKLFFIQACQGKKGQSAVYI---EADGPATSLICTDAVRD 396
Query: 685 RIPIHADFLIVFSTVPGYYSWRNTTRGSWVYAISFVEELXTMGP 816
P+ ADFLI +TVP + S+R+ RG+W + S + L M P
Sbjct: 397 SFPVDADFLISMATVPSFVSYRDKQRGTW-FIQSLCKYLIQMVP 439
Score = 54.0 bits (124), Expect = 5e-06
Identities = 28/78 (35%), Positives = 39/78 (50%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
RG+ +I N+ F +LK R GT +D + L V + LGF V V N E + + +
Sbjct: 249 RGICLIINNHVFPETSLKPRDGTMIDEECLRDVFKWLGFDVEVHLNCTREKMLSLLWDLG 308
Query: 437 EMDHTDNDCLLVAVLSHG 490
DH C+ VLSHG
Sbjct: 309 RRDHRQMSCVACFVLSHG 326
>UniRef50_Q8ITP2 Cluster: AmphiCASP-6; n=2; Chordata|Rep:
AmphiCASP-6 - Branchiostoma floridae (Florida lancelet)
(Amphioxus)
Length = 400
Score = 66.5 bits (155), Expect = 8e-10
Identities = 33/91 (36%), Positives = 55/91 (60%), Gaps = 2/91 (2%)
Frame = +2
Query: 242 HEPQYRGMAIIFNHEHFE-IHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINR 418
+ PQ RG+ ++F++E F + R G++VD+ +L + GLGFSV VL + +I +
Sbjct: 146 NHPQ-RGLCLVFDNEEFHWTTKMNRRRGSHVDAGNLKVMFEGLGFSVEVLKDKEITEIRQ 204
Query: 419 YIQQIS-EMDHTDNDCLLVAVLSHGELGMLY 508
+ + + DH+ +DC + LSHGE GM+Y
Sbjct: 205 ILHSAALKYDHSQSDCFVCVFLSHGEDGMIY 235
Score = 60.5 bits (140), Expect = 5e-08
Identities = 36/86 (41%), Positives = 45/86 (52%), Gaps = 12/86 (13%)
Frame = +1
Query: 550 FTADKCPTLAGKPKLFFIQACQG----------DKLDGGITLSNTETDGXXXXXYR--IP 693
F AD+C +L GKPKLFFIQAC+G D+ DG E R +P
Sbjct: 250 FRADRCTSLKGKPKLFFIQACRGAKHEIPVEPLDEPDGLEGSGEAEPMDMVDAGVRPTLP 309
Query: 694 IHADFLIVFSTVPGYYSWRNTTRGSW 771
ADFL+ +S G+YS R+T GSW
Sbjct: 310 AGADFLMAYSVSEGFYSHRDTVNGSW 335
>UniRef50_Q56VC9 Cluster: Caspase-8; n=3; Euteleostei|Rep: Caspase-8
- Oryzias latipes (Medaka fish) (Japanese ricefish)
Length = 481
Score = 66.1 bits (154), Expect = 1e-09
Identities = 36/90 (40%), Positives = 53/90 (58%), Gaps = 1/90 (1%)
Frame = +2
Query: 242 HEPQYRGMAIIFNHE-HFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINR 418
HEP RG+ +IFN++ F NL R GT D SL+ + GF V V +NL A+ I
Sbjct: 238 HEP--RGLCVIFNNKLFFPESNLGERGGTEKDEKSLNNLFHRFGFEVVVHNNLTADLIES 295
Query: 419 YIQQISEMDHTDNDCLLVAVLSHGELGMLY 508
I ++ + + + +D L+V VLSHG+ G +Y
Sbjct: 296 EITKLGQRNFSHDDALVVCVLSHGDNGCVY 325
Score = 50.4 bits (115), Expect = 6e-05
Identities = 31/80 (38%), Positives = 39/80 (48%), Gaps = 7/80 (8%)
Frame = +1
Query: 550 FTADKCPTLAGKPKLFFIQACQGDKLDGGITL-------SNTETDGXXXXXYRIPIHADF 708
F + + P+L GKPKLFFIQACQG G + E D +P ADF
Sbjct: 341 FPSYRAPSLIGKPKLFFIQACQGTLAQSGYLPGSEVKGDAELEADASSSTSNSVPNDADF 400
Query: 709 LIVFSTVPGYYSWRNTTRGS 768
L+ +TV S+RN GS
Sbjct: 401 LLGMATVAECKSFRNKYTGS 420
>UniRef50_A2BGE2 Cluster: Novel protein similar to caspase 8; n=4;
Danio rerio|Rep: Novel protein similar to caspase 8 -
Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 366
Score = 66.1 bits (154), Expect = 1e-09
Identities = 40/106 (37%), Positives = 56/106 (52%), Gaps = 6/106 (5%)
Frame = +1
Query: 472 CCVESWRIRY-VVSKDTHYKP-DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITL 645
CCV S V+ D P D++ F C +LAGKPK+FFIQAC+G ++ + +
Sbjct: 199 CCVLSHGNESGVLGSDEKICPVDDITSPFNGANCSSLAGKPKVFFIQACRGHEIQSKVMV 258
Query: 646 SN----TETDGXXXXXYRIPIHADFLIVFSTVPGYYSWRNTTRGSW 771
++ + T IP +DFLI STV GY S R+ T G+W
Sbjct: 259 ADGSGGSRTQKPGRVSVSIPKDSDFLIARSTVEGYVSIRDRTSGTW 304
Score = 57.6 bits (133), Expect = 4e-07
Identities = 32/84 (38%), Positives = 51/84 (60%), Gaps = 1/84 (1%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
RG+ +IFN+E+F+ ++K R G+ +D+ SL + LGFSV + + + R +++ S
Sbjct: 130 RGLCLIFNNENFKDPDMK-RHGSQMDTASLKDLFEWLGFSVEIKQDQTVSAMKRTLKEYS 188
Query: 437 EMDHTDNDCLLVAVLSHG-ELGML 505
E D DC + VLSHG E G+L
Sbjct: 189 E-DRKHGDCFVCCVLSHGNESGVL 211
>UniRef50_A7S119 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 229
Score = 66.1 bits (154), Expect = 1e-09
Identities = 33/94 (35%), Positives = 53/94 (56%)
Frame = +1
Query: 532 DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFL 711
++L F CP+L GKPK+FF+QAC+G K + + ++++ +P +DFL
Sbjct: 95 ESLTNKFRGSTCPSLQGKPKVFFLQACRGAKKE--LVAVESDSEPVPIRHSGLPSDSDFL 152
Query: 712 IVFSTVPGYYSWRNTTRGSWVYAISFVEELXTMG 813
I +++ PGY S+RN GSW + S V+ G
Sbjct: 153 ICYASSPGYESYRNPELGSW-FIRSIVDVFRNFG 185
Score = 46.4 bits (105), Expect = 0.001
Identities = 22/84 (26%), Positives = 41/84 (48%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
+G +I N++ F + R G+ D L ++ G +V + N + ++ +++ S
Sbjct: 2 KGYVLIINNQEFPSRSDVERKGSAEDVKQLYQLFDDFGMTVKTIQNKTSLEMLELLEETS 61
Query: 437 EMDHTDNDCLLVAVLSHGELGMLY 508
E D T DC + +LSHG +Y
Sbjct: 62 EKDFTKFDCFICIILSHGSHSGIY 85
>UniRef50_Q9I8J3 Cluster: Caspase-8; n=11; Danio rerio|Rep:
Caspase-8 - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 476
Score = 65.3 bits (152), Expect = 2e-09
Identities = 39/97 (40%), Positives = 53/97 (54%), Gaps = 11/97 (11%)
Frame = +1
Query: 565 CPTLAGKPKLFFIQACQGDKLDGGITLSN-----------TETDGXXXXXYRIPIHADFL 711
C TLA KPKLFFIQACQGD+ G+ S+ E D +IPI ADFL
Sbjct: 340 CRTLASKPKLFFIQACQGDENQAGVWTSDGREDAPEEDEEYEEDAGIIVLRKIPIEADFL 399
Query: 712 IVFSTVPGYYSWRNTTRGSWVYAISFVEELXTMGPPK 822
I +TV Y S+R+T +GS ++ +++ + P K
Sbjct: 400 IGMATVEHYLSYRHTKKGS-IFIQELCKKMEELCPKK 435
Score = 55.6 bits (128), Expect = 1e-06
Identities = 28/77 (36%), Positives = 42/77 (54%)
Frame = +2
Query: 269 IIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQISEMDH 448
II N+ E NL RTGT++D D L+K+ + F + V ++L A I I+Q + +H
Sbjct: 242 IINNYNFLESTNLLKRTGTDMDKDRLAKLFSRMHFQIEVRNDLEAWAIKDEIKQFANRNH 301
Query: 449 TDNDCLLVAVLSHGELG 499
+ +LSHGE G
Sbjct: 302 ASMGAFVCCILSHGEKG 318
>UniRef50_Q5C0Y4 Cluster: SJCHGC07329 protein; n=1; Schistosoma
japonicum|Rep: SJCHGC07329 protein - Schistosoma
japonicum (Blood fluke)
Length = 239
Score = 65.3 bits (152), Expect = 2e-09
Identities = 37/108 (34%), Positives = 54/108 (50%), Gaps = 10/108 (9%)
Frame = +1
Query: 502 VVSKDTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLD----------GGITLSN 651
+ S H D L FT +CP LAGKPK IQAC+G++ + + ++
Sbjct: 81 IASDGIHVSIDELVSCFTNKRCPLLAGKPKFILIQACRGEERNHNDSKMGDFLDSLPSNS 140
Query: 652 TETDGXXXXXYRIPIHADFLIVFSTVPGYYSWRNTTRGSWVYAISFVE 795
E +P +D +I ++T+PG+ SWR+ T GSW Y FVE
Sbjct: 141 REISLDPSSWLSLPHMSDCVIAYTTLPGFVSWRSETEGSW-YVKVFVE 187
>UniRef50_UPI0000586459 Cluster: PREDICTED: similar to caspase-3,
partial; n=10; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to caspase-3, partial -
Strongylocentrotus purpuratus
Length = 437
Score = 64.9 bits (151), Expect = 2e-09
Identities = 29/81 (35%), Positives = 52/81 (64%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
RG+A+I N+++F+ + R GT++D +L + L F V V ++L+ DI + I+Q+
Sbjct: 164 RGIALIINNKNFK--TMPPRRGTDIDCRNLENIFTQLDFDVVVHNDLKKRDIQQKIEQVR 221
Query: 437 EMDHTDNDCLLVAVLSHGELG 499
+ +H+ DC + A+L+HGE G
Sbjct: 222 KHNHSQFDCFIFAILTHGEEG 242
Score = 54.4 bits (125), Expect = 3e-06
Identities = 21/30 (70%), Positives = 26/30 (86%)
Frame = +1
Query: 550 FTADKCPTLAGKPKLFFIQACQGDKLDGGI 639
F +D+CPTL GKPKLFF+QAC+G KLD G+
Sbjct: 261 FCSDRCPTLNGKPKLFFLQACRGKKLDDGV 290
Score = 46.8 bits (106), Expect = 7e-04
Identities = 17/38 (44%), Positives = 24/38 (63%)
Frame = +1
Query: 658 TDGXXXXXYRIPIHADFLIVFSTVPGYYSWRNTTRGSW 771
TD ++P +D L+ ++TVPG+ SWRN RGSW
Sbjct: 339 TDSFASSRSKVPSQSDMLLAYATVPGFVSWRNAERGSW 376
>UniRef50_UPI0000F2DFE7 Cluster: PREDICTED: similar to apoptotic
cysteine protease proMch4; n=1; Monodelphis
domestica|Rep: PREDICTED: similar to apoptotic cysteine
protease proMch4 - Monodelphis domestica
Length = 452
Score = 64.5 bits (150), Expect = 3e-09
Identities = 37/94 (39%), Positives = 47/94 (50%), Gaps = 4/94 (4%)
Frame = +1
Query: 547 YFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYR----IPIHADFLI 714
YF A +CP LA KPKLFF QACQG + + L IP+ ADFL+
Sbjct: 310 YFKAHRCPGLANKPKLFFFQACQGPDIQESMLLEEDAKISPPIQVETPQRYIPVEADFLL 369
Query: 715 VFSTVPGYYSWRNTTRGSWVYAISFVEELXTMGP 816
+TV G + R+T +GSW Y + L M P
Sbjct: 370 GMATVDGCCAIRHTIKGSW-YIQALCHRLKCMVP 402
Score = 63.3 bits (147), Expect = 7e-09
Identities = 32/86 (37%), Positives = 49/86 (56%), Gaps = 1/86 (1%)
Frame = +2
Query: 254 YRGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQI 433
+RG IIFN+ FE +K R G+ D+D L V LGF+V + N ++ +QQ
Sbjct: 212 HRGHCIIFNN--FEFQTMKRRRGSCKDADELKSVFEWLGFTVKIHPNTEKREMEDILQQC 269
Query: 434 S-EMDHTDNDCLLVAVLSHGELGMLY 508
S +H ++DC + VL+HGE G ++
Sbjct: 270 STSPEHRESDCFVCCVLTHGESGSVF 295
>UniRef50_Q90WU0 Cluster: Caspase 9; n=2; Gallus gallus|Rep: Caspase
9 - Gallus gallus (Chicken)
Length = 403
Score = 64.5 bits (150), Expect = 3e-09
Identities = 30/78 (38%), Positives = 50/78 (64%), Gaps = 1/78 (1%)
Frame = +2
Query: 260 GMAIIFNHEHFEIHN-LKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
G +IFN+ F + L +R G+++D + L K R L F V L NL+A++I+ +++++
Sbjct: 148 GHCLIFNNVSFSRDSDLSTRAGSDIDCEKLEKRFRSLCFHVRTLRNLKAQEIDVELRKLA 207
Query: 437 EMDHTDNDCLLVAVLSHG 490
+DH+ DC LV +LSHG
Sbjct: 208 RLDHSALDCCLVVILSHG 225
Score = 58.4 bits (135), Expect = 2e-07
Identities = 34/97 (35%), Positives = 46/97 (47%), Gaps = 22/97 (22%)
Frame = +1
Query: 547 YFTADKCPTLAGKPKLFFIQACQGDKLDGGITLS-----------NTETDG--------- 666
YF +CP+L GKPKLFFIQAC G++ D G + + E+D
Sbjct: 253 YFNGSQCPSLRGKPKLFFIQACGGEQKDQGFEVDCESPQDETCRRSIESDAIPFQAPSGN 312
Query: 667 --XXXXXYRIPIHADFLIVFSTVPGYYSWRNTTRGSW 771
+P D L+ +ST PG+ SWR+ GSW
Sbjct: 313 EDEPDAVASLPTPGDILVSYSTFPGFVSWRDKVSGSW 349
>UniRef50_Q4SC67 Cluster: Chromosome undetermined SCAF14659, whole
genome shotgun sequence; n=2; Deuterostomia|Rep:
Chromosome undetermined SCAF14659, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 445
Score = 64.5 bits (150), Expect = 3e-09
Identities = 32/90 (35%), Positives = 50/90 (55%), Gaps = 1/90 (1%)
Frame = +2
Query: 224 ICSLL*HEPQYRGMAIIFNHEHFEIHN-LKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLR 400
+C E G +I N+ FE + L +R G+NVD D L + + L F+V V NL+
Sbjct: 145 VCQSYRMEANPLGHCLIINNVEFEPKSGLSNRNGSNVDCDRLERRFKALNFTVKVKTNLK 204
Query: 401 AEDINRYIQQISEMDHTDNDCLLVAVLSHG 490
I + + +S++DH+ DC +V +LSHG
Sbjct: 205 QRQIRQELSALSKVDHSQYDCCVVVILSHG 234
Score = 58.0 bits (134), Expect = 3e-07
Identities = 37/100 (37%), Positives = 46/100 (46%), Gaps = 25/100 (25%)
Frame = +1
Query: 547 YFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETD----GXXXXXYRIPI------ 696
Y CP+L GKPKLFFIQAC GD+ D G +S E + G IP+
Sbjct: 262 YLNGQYCPSLQGKPKLFFIQACGGDEKDTGFQVSPDEFEPPVVGADDQTDAIPVSSSSDS 321
Query: 697 ---------------HADFLIVFSTVPGYYSWRNTTRGSW 771
+D L+ +ST PGY SWR+ GSW
Sbjct: 322 LSMSDEPDARASLPTSSDILVSYSTFPGYVSWRDPKAGSW 361
>UniRef50_UPI0001554FA5 Cluster: PREDICTED: similar to initiator
caspase, partial; n=1; Ornithorhynchus anatinus|Rep:
PREDICTED: similar to initiator caspase, partial -
Ornithorhynchus anatinus
Length = 480
Score = 64.1 bits (149), Expect = 4e-09
Identities = 31/80 (38%), Positives = 47/80 (58%)
Frame = +2
Query: 260 GMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQISE 439
G +I N+ F+ + +R G + D+ +L KV L F V +NL+ E I+R ++ SE
Sbjct: 237 GFCVIINNSEFQ-NPQNTRRGADKDAAALDKVFSWLQFKVEHHNNLKGEAISRVLRAYSE 295
Query: 440 MDHTDNDCLLVAVLSHGELG 499
DHTD DC + +LSHG+ G
Sbjct: 296 RDHTDQDCFICCLLSHGQKG 315
Score = 56.4 bits (130), Expect = 8e-07
Identities = 33/92 (35%), Positives = 46/92 (50%), Gaps = 3/92 (3%)
Frame = +1
Query: 550 FTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTE---TDGXXXXXYRIPIHADFLIVF 720
FT+ C TLA KPK+FF+QACQG + GG++L E + +P AD L+
Sbjct: 334 FTSSACRTLATKPKIFFVQACQGGQGQGGLSLRGREGALLEADAVVIPSVPDWADLLVGM 393
Query: 721 STVPGYYSWRNTTRGSWVYAISFVEELXTMGP 816
+TV + +R GS Y + L T P
Sbjct: 394 ATVEDFICFRRPRHGS-EYIQALCRALETFCP 424
>UniRef50_Q09HM6 Cluster: Caspase-8; n=1; Molgula tectiformis|Rep:
Caspase-8 - Molgula tectiformis
Length = 700
Score = 64.1 bits (149), Expect = 4e-09
Identities = 41/107 (38%), Positives = 55/107 (51%), Gaps = 7/107 (6%)
Frame = +1
Query: 472 CCVESWRIRYVVSKDTHYK--PDNLWYYFTADKCPTLAGKPKLFFIQACQG-DKLDGGIT 642
C + S R +V YK ++ +FT C TL KPKL FIQAC G ++++G
Sbjct: 511 CVILSHGKRNIVYSVDGYKFRISDIQSFFTTTTCSTLQDKPKLVFIQACAGANEMEGKEI 570
Query: 643 L----SNTETDGXXXXXYRIPIHADFLIVFSTVPGYYSWRNTTRGSW 771
S+ +DG P ADFL+ ST PGY S+R+T GSW
Sbjct: 571 QCQQESDIHSDGDDNIKEATPFLADFLLANSTWPGYRSYRSTKTGSW 617
Score = 56.8 bits (131), Expect = 6e-07
Identities = 23/68 (33%), Positives = 42/68 (61%)
Frame = +2
Query: 305 LKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQISEMDHTDNDCLLVAVLS 484
LK+R G+ +D+D++ + G F V ++L+ ++ IQ+ SEMDH+ D + +LS
Sbjct: 456 LKNRAGSKIDADAIEDIFTGFSFKVHRCNDLKHREMQICIQEFSEMDHSKYDSFVCVILS 515
Query: 485 HGELGMLY 508
HG+ ++Y
Sbjct: 516 HGKRNIVY 523
>UniRef50_A5JSK5 Cluster: Cysteine protease; n=2; Eukaryota|Rep:
Cysteine protease - Oryzias latipes (Medaka fish)
(Japanese ricefish)
Length = 319
Score = 63.7 bits (148), Expect = 6e-09
Identities = 33/89 (37%), Positives = 49/89 (55%)
Frame = +1
Query: 550 FTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFLIVFSTV 729
F A + L GKPK+F IQACQG ++ G+ L++ E D IP AD L+ +TV
Sbjct: 186 FKASEQSALTGKPKMFLIQACQGGQIHKGVALTDVEAD--DCSTQTIPEEADILVALATV 243
Query: 730 PGYYSWRNTTRGSWVYAISFVEELXTMGP 816
Y ++R+ + GSW + S ++L P
Sbjct: 244 EDYPAYRHISEGSW-FVQSLCQQLKERCP 271
>UniRef50_Q69HP8 Cluster: Caspase-1-like; n=1; Ciona
intestinalis|Rep: Caspase-1-like - Ciona intestinalis
(Transparent sea squirt)
Length = 254
Score = 63.7 bits (148), Expect = 6e-09
Identities = 31/87 (35%), Positives = 54/87 (62%), Gaps = 1/87 (1%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
RG+ +IF+ E+F+ + L+ R G+ +D L + LGF+ V H+ +D+ +++IS
Sbjct: 64 RGIFLIFDQENFD-YGLQQRVGSKLDRIVLEETAIKLGFTPNVCHDYTKDDVYAELRKIS 122
Query: 437 EMDHTDNDCLLVAVLSHGELG-MLYPK 514
+M+H+ DC A+L+HGE M+Y K
Sbjct: 123 QMNHSQYDCFACAILTHGEEDEMVYAK 149
Score = 47.6 bits (108), Expect = 4e-04
Identities = 21/42 (50%), Positives = 29/42 (69%)
Frame = +1
Query: 502 VVSKDTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKL 627
V +KD K L +A +CP+LAGKPKLFF+QAC+G ++
Sbjct: 146 VYAKDDSMKLKTLISRVSATECPSLAGKPKLFFVQACRGKEI 187
>UniRef50_UPI00015553DC Cluster: PREDICTED: similar to caspase-15;
n=1; Ornithorhynchus anatinus|Rep: PREDICTED: similar to
caspase-15 - Ornithorhynchus anatinus
Length = 237
Score = 63.3 bits (147), Expect = 7e-09
Identities = 32/81 (39%), Positives = 44/81 (54%), Gaps = 2/81 (2%)
Frame = +1
Query: 532 DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNT--ETDGXXXXXYRIPIHAD 705
+ ++ F CP L KPK+F IQAC+GD+ DGG+ + E R+P +D
Sbjct: 93 EEIFKLFNNANCPNLREKPKIFIIQACRGDRTDGGVEAFDNVPEEMDDTSNVKRLPTTSD 152
Query: 706 FLIVFSTVPGYYSWRNTTRGS 768
F IV+ST G+ S RN GS
Sbjct: 153 FFIVYSTQKGHVSVRNPLMGS 173
>UniRef50_UPI0000ECB87F Cluster: Caspase-10 precursor (EC 3.4.22.63)
(CASP-10) (ICE-like apoptotic protease 4) (Apoptotic
protease Mch-4) (FAS-associated death domain protein
interleukin-1B-converting enzyme 2) (FLICE2) [Contains:
Caspase-10 subunit p23/17; Caspase-10 subunit p12].;
n=2; Gallus gallus|Rep: Caspase-10 precursor (EC
3.4.22.63) (CASP-10) (ICE-like apoptotic protease 4)
(Apoptotic protease Mch-4) (FAS-associated death domain
protein interleukin-1B-converting enzyme 2) (FLICE2)
[Contains: Caspase-10 subunit p23/17; Caspase-10 subunit
p12]. - Gallus gallus
Length = 537
Score = 62.9 bits (146), Expect = 1e-08
Identities = 34/99 (34%), Positives = 51/99 (51%), Gaps = 7/99 (7%)
Frame = +1
Query: 547 YFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSN-------TETDGXXXXXYRIPIHAD 705
YFTA +CP L KPKLFF+QACQG ++ + + + IP AD
Sbjct: 390 YFTAKQCPQLTEKPKLFFVQACQGKEVQRPVYVETDARVPDFSSVPQSTSPSESIPEEAD 449
Query: 706 FLIVFSTVPGYYSWRNTTRGSWVYAISFVEELXTMGPPK 822
FL+ +T+ GY S+R+ G+W Y + +L + P +
Sbjct: 450 FLLGMATIDGYASFRHVQEGTW-YIQALCSKLQLLVPSR 487
Score = 52.8 bits (121), Expect = 1e-05
Identities = 34/108 (31%), Positives = 57/108 (52%), Gaps = 2/108 (1%)
Frame = +2
Query: 197 TLCENACRKICSLL*HEPQYRGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFS 376
T+C ++ ++ S P+ RG+ ++ N+ F+ L+ R G+ D+ L +V LG
Sbjct: 273 TVCYSSFLQVSSYKMDGPR-RGICLVINNVKFD-GVLQERKGSYKDACELERVFTWLGLD 330
Query: 377 VTVLHNLRAEDINRYIQ--QISEMDHTDNDCLLVAVLSHGELGMLYPK 514
V + ++ I +Q Q SE DH + DC + +LSHGE G +Y K
Sbjct: 331 VRTYTDQTSDQIKELMQAWQRSE-DHKNRDCFVCCILSHGESGAVYGK 377
>UniRef50_UPI0000E48C15 Cluster: PREDICTED: similar to caspase 8;
n=1; Strongylocentrotus purpuratus|Rep: PREDICTED:
similar to caspase 8 - Strongylocentrotus purpuratus
Length = 300
Score = 62.1 bits (144), Expect = 2e-08
Identities = 35/92 (38%), Positives = 49/92 (53%)
Frame = +1
Query: 532 DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFL 711
D L F D P+L KPKLFFIQACQG+ G + + T +P ++D L
Sbjct: 161 DALTGLFRGDYVPSLVNKPKLFFIQACQGNDAQGAVDIQQDAT-----ATATLPHNSDTL 215
Query: 712 IVFSTVPGYYSWRNTTRGSWVYAISFVEELXT 807
+ +T+PGY S+RN GS ++ IS + T
Sbjct: 216 VSHATIPGYASFRNAYSGS-LFIISLCNIINT 246
Score = 40.7 bits (91), Expect = 0.045
Identities = 20/48 (41%), Positives = 26/48 (54%)
Frame = +2
Query: 365 LGFSVTVLHNLRAEDINRYIQQISEMDHTDNDCLLVAVLSHGELGMLY 508
L F V + A D +QQI+ MDHT DC + +LSHG G +Y
Sbjct: 104 LKFKTYVKKDPTARDYVASLQQIANMDHTKFDCFVCVILSHGCRGSVY 151
>UniRef50_UPI0000E472FD Cluster: PREDICTED: similar to caspase 8;
n=2; Strongylocentrotus purpuratus|Rep: PREDICTED:
similar to caspase 8 - Strongylocentrotus purpuratus
Length = 790
Score = 62.1 bits (144), Expect = 2e-08
Identities = 31/74 (41%), Positives = 42/74 (56%)
Frame = +1
Query: 550 FTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFLIVFSTV 729
F D P+L KPKLFFIQACQG + G + + T +P +D L+ STV
Sbjct: 663 FRGDYVPSLVNKPKLFFIQACQGREAQGAVDIQQDAT-------ATLPNESDTLVSMSTV 715
Query: 730 PGYYSWRNTTRGSW 771
PGY S R+ ++G+W
Sbjct: 716 PGYASNRSVSQGTW 729
Score = 60.9 bits (141), Expect = 4e-08
Identities = 31/85 (36%), Positives = 48/85 (56%), Gaps = 1/85 (1%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRG-LGFSVTVLHNLRAEDINRYIQQI 433
RG+ IIFN E+F NL R GT D ++L + L F + V + A+ + +Q+I
Sbjct: 435 RGLCIIFNAENFTRKNLHKRDGTEKDVEALLNTFQNRLKFKIRVEQDPTADKYLKCLQEI 494
Query: 434 SEMDHTDNDCLLVAVLSHGELGMLY 508
+ DH++ DC + +LSHG G +Y
Sbjct: 495 ARSDHSEYDCFVCIILSHGCKGHVY 519
Score = 58.8 bits (136), Expect = 2e-07
Identities = 34/92 (36%), Positives = 46/92 (50%), Gaps = 1/92 (1%)
Frame = +1
Query: 499 YVVSKDTHYKP-DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXX 675
+V D P D L F + P+L KPKLFFIQACQGD + + T
Sbjct: 517 HVYGTDGRLMPIDALTGLFRGEYVPSLVNKPKLFFIQACQGDNAQRAVDIQQDATT---- 572
Query: 676 XXYRIPIHADFLIVFSTVPGYYSWRNTTRGSW 771
+P +D L+ STV GY S R+ ++G+W
Sbjct: 573 ---TLPNESDTLVSMSTVSGYASNRSVSQGTW 601
>UniRef50_UPI0000587370 Cluster: PREDICTED: similar to caspase 8,
partial; n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to caspase 8, partial -
Strongylocentrotus purpuratus
Length = 447
Score = 62.1 bits (144), Expect = 2e-08
Identities = 30/85 (35%), Positives = 48/85 (56%), Gaps = 1/85 (1%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLR-GLGFSVTVLHNLRAEDINRYIQQI 433
RG+ IIFN E+F + +LK R GT D ++L + L F+ V ++ + +Q+I
Sbjct: 350 RGICIIFNAENFAVEHLKKRKGTQKDVEALENTFQNNLKFTTQVKNDPTKNEYKECLQEI 409
Query: 434 SEMDHTDNDCLLVAVLSHGELGMLY 508
MDH+ DC + +LSHG G ++
Sbjct: 410 RRMDHSKYDCFVCVILSHGCEGHVF 434
>UniRef50_Q16PQ5 Cluster: Ecdysone-inducible caspase, putative; n=2;
Culicidae|Rep: Ecdysone-inducible caspase, putative -
Aedes aegypti (Yellowfever mosquito)
Length = 449
Score = 62.1 bits (144), Expect = 2e-08
Identities = 39/97 (40%), Positives = 51/97 (52%), Gaps = 6/97 (6%)
Frame = +1
Query: 499 YVVSKDTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLD-GGITLS-NTETDGXX 672
Y+ Y D L + A+ CP L +PKLFF C+GD D G + L+ +TE DG
Sbjct: 291 YLNDNSVLYVEDVLALFNNAN-CPKLIRRPKLFFFSICRGDNPDYGTLRLAEHTERDGMI 349
Query: 673 XXXY----RIPIHADFLIVFSTVPGYYSWRNTTRGSW 771
+P +AD LI FSTVPGY + R+ GSW
Sbjct: 350 NLKKDPPTNMPTYADMLICFSTVPGYAAHRDKQYGSW 386
Score = 43.2 bits (97), Expect = 0.008
Identities = 19/78 (24%), Positives = 39/78 (50%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
RG+ I N + +R G D +L + + LGF+V +L +++ N I+++
Sbjct: 204 RGVVFIVNVITYINETHPTRNGAEADKYNLVSLFQQLGFTVFYYEDLTSDEFNNLIKELK 263
Query: 437 EMDHTDNDCLLVAVLSHG 490
+ + +C + +L+HG
Sbjct: 264 QSSYLSTECFVFYILAHG 281
>UniRef50_Q0Z855 Cluster: Caspase-2; n=1; Haemaphysalis
longicornis|Rep: Caspase-2 - Haemaphysalis longicornis
(Bush tick)
Length = 340
Score = 62.1 bits (144), Expect = 2e-08
Identities = 30/85 (35%), Positives = 51/85 (60%), Gaps = 1/85 (1%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
RG II N+ F H+L+ R G+ +D D ++ + R L F+V++ NL A++ ++
Sbjct: 24 RGSCIIVNNADFHDHSLRCREGSQLDVDRMAGLFRQLHFNVSIASNLSAKETKDLLRGFQ 83
Query: 437 EMD-HTDNDCLLVAVLSHGELGMLY 508
+ + D +CL V ++SHGE G+LY
Sbjct: 84 KAETQKDAECLAVILMSHGEDGVLY 108
Score = 37.9 bits (84), Expect = 0.32
Identities = 16/35 (45%), Positives = 21/35 (60%)
Frame = +1
Query: 535 NLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGI 639
+++ F + CP L GKPKLFFI +G D GI
Sbjct: 120 DVYQLFDNENCPNLRGKPKLFFIPGSRGCMWDNGI 154
>UniRef50_Q9IB62 Cluster: Caspase-10; n=5; Xenopus|Rep: Caspase-10 -
Xenopus laevis (African clawed frog)
Length = 520
Score = 61.7 bits (143), Expect = 2e-08
Identities = 37/92 (40%), Positives = 47/92 (51%), Gaps = 2/92 (2%)
Frame = +1
Query: 547 YFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXY--RIPIHADFLIVF 720
YFTA C +L KPKLFFIQACQG + + Y +P ADFL+
Sbjct: 371 YFTATSCISLTLKPKLFFIQACQGIYTHPSSKVEPDASVPVEHKKYIVNVPKEADFLLGM 430
Query: 721 STVPGYYSWRNTTRGSWVYAISFVEELXTMGP 816
STV GY ++R+ GSW Y + + L M P
Sbjct: 431 STVDGYAAYRHKKYGSW-YIQALCKNLVEMVP 461
Score = 56.0 bits (129), Expect = 1e-06
Identities = 27/83 (32%), Positives = 46/83 (55%)
Frame = +2
Query: 251 QYRGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQ 430
++RG +I ++ F K R G++ D+ +LS V LG V ++ NL E I +++
Sbjct: 273 KHRGYCLIIDNSIFM--KGKRREGSDKDAGALSDVFSWLGLEVEIVKNLGTEQIRGCLKR 330
Query: 431 ISEMDHTDNDCLLVAVLSHGELG 499
DH++ DC + +L+HGE G
Sbjct: 331 FKSKDHSERDCFVCCILTHGESG 353
>UniRef50_Q6E5N8 Cluster: Caspase 8; n=1; Ictalurus punctatus|Rep:
Caspase 8 - Ictalurus punctatus (Channel catfish)
Length = 366
Score = 61.7 bits (143), Expect = 2e-08
Identities = 41/110 (37%), Positives = 56/110 (50%), Gaps = 15/110 (13%)
Frame = +1
Query: 532 DNLWYYFTADKCPTLAGKPKLFFIQACQG-----------DKLDGGITLSNTETDGXXXX 678
D+++ F+ + CP+L KPK+F IQAC+G D + T + TE +
Sbjct: 209 DDIFGPFSGNSCPSLINKPKVFIIQACRGKEYHLPVEVQPDSYEEEDTEAETEDEKSLET 268
Query: 679 X----YRIPIHADFLIVFSTVPGYYSWRNTTRGSWVYAISFVEELXTMGP 816
IP ADFLI STV GYYS R+T GSW + S ++L T P
Sbjct: 269 DAVQMMTIPADADFLIARSTVKGYYSMRDTISGSW-FIQSLCQQLKTYCP 317
Score = 59.7 bits (138), Expect = 9e-08
Identities = 30/78 (38%), Positives = 46/78 (58%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
RG +I N+ +F LK R G+ +D DSL +V + LGF+V V N AE + +++ S
Sbjct: 118 RGFCVIINNVNFA-SPLKERYGSKLDEDSLKEVFQWLGFNVCVHKNQTAEQMKDLLKKYS 176
Query: 437 EMDHTDNDCLLVAVLSHG 490
+ H D DC + ++SHG
Sbjct: 177 QQHH-DGDCFVCCIMSHG 193
>UniRef50_Q5D0W5 Cluster: Caspase 3C; n=2; Hydra vulgaris|Rep:
Caspase 3C - Hydra attenuata (Hydra) (Hydra vulgaris)
Length = 326
Score = 60.1 bits (139), Expect = 7e-08
Identities = 31/68 (45%), Positives = 37/68 (54%), Gaps = 2/68 (2%)
Frame = +1
Query: 574 LAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXX--YRIPIHADFLIVFSTVPGYYSW 747
LAGKPKLF IQAC+G K I + G + + +DFL +STV YYSW
Sbjct: 189 LAGKPKLFLIQACRGTKYMESIDTVDGFGPGLSNESNVLDVTVESDFLYAYSTVQSYYSW 248
Query: 748 RNTTRGSW 771
RN GSW
Sbjct: 249 RNQKLGSW 256
Score = 53.6 bits (123), Expect = 6e-06
Identities = 24/65 (36%), Positives = 40/65 (61%)
Frame = +2
Query: 314 RTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQISEMDHTDNDCLLVAVLSHGE 493
R GT+VD+ SL + LGF + L N ++ D+ ++Q + D++ C +VA+LSHGE
Sbjct: 105 RLGTDVDAQSLCDLFLKLGFKIDRLDNPKSTDVLNILKQAANEDYSSMSCCVVALLSHGE 164
Query: 494 LGMLY 508
G ++
Sbjct: 165 EGKIF 169
>UniRef50_Q5SVL3 Cluster: Caspase 7, apoptosis-related cysteine
peptidase; n=4; Homo sapiens|Rep: Caspase 7,
apoptosis-related cysteine peptidase - Homo sapiens
(Human)
Length = 253
Score = 60.1 bits (139), Expect = 7e-08
Identities = 53/185 (28%), Positives = 89/185 (48%), Gaps = 3/185 (1%)
Frame = +2
Query: 260 GMAIIFNHEHFE-IHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
G II N+++F+ + + R GT+ D+++L K R LGF V V ++ + +++ S
Sbjct: 68 GKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKAS 127
Query: 437 EMDHTDNDCLLVAVLSHGELGMLYPKTLIINQIICGITSLLINVQL*LENQSCSLFKLAK 616
E DHT+ C +LSHGE M ++ + Q G+ + L+ L +
Sbjct: 128 EEDHTNAACFACILLSHGEENM---ESCSVTQ--AGVQRRDLGR---LQPPPPRLAEGPS 179
Query: 617 VIS*MVE*HYPTLKQMVLRLHPTESQFMLTF*LCSQRYQVITLGETQLVALGFMQ--SPL 790
++ P++ QM++ T SQ+ LT R+Q IT G Q A G + +P
Sbjct: 180 LMMASRPTRGPSMTQMLIL--DTRSQWKLTSSSPIPRFQAITRGGAQEEAPGLCKPSAPS 237
Query: 791 WRNXE 805
WR+ E
Sbjct: 238 WRSTE 242
>UniRef50_Q8I749 Cluster: Caspase-related protein; n=1; Suberites
domuncula|Rep: Caspase-related protein - Suberites
domuncula (Sponge)
Length = 496
Score = 59.7 bits (138), Expect = 9e-08
Identities = 34/78 (43%), Positives = 42/78 (53%), Gaps = 9/78 (11%)
Frame = +1
Query: 565 CPTLAGKPKLFFIQACQGDKLDGGI---TLSNTETD------GXXXXXYRIPIHADFLIV 717
CPTL GKPK+FF+QAC+GD G +S TE D G IP ADF
Sbjct: 359 CPTLRGKPKIFFVQACRGDIESMGFKNEEVSKTEDDLQADMPGGHLHTDTIPQEADFFYG 418
Query: 718 FSTVPGYYSWRNTTRGSW 771
F+T GY ++R+ GSW
Sbjct: 419 FATPLGYAAYRSRRHGSW 436
>UniRef50_Q16FR8 Cluster: Caspase-1; n=1; Aedes aegypti|Rep:
Caspase-1 - Aedes aegypti (Yellowfever mosquito)
Length = 283
Score = 59.7 bits (138), Expect = 9e-08
Identities = 35/84 (41%), Positives = 48/84 (57%), Gaps = 8/84 (9%)
Frame = +1
Query: 547 YFTADKCPTLAGKPKLFFIQACQGDKLDGGITL------SNTETD--GXXXXXYRIPIHA 702
+FT ++AGKPKLF +QAC+G KLD G+ L ++ D Y P A
Sbjct: 137 HFTPTALKSMAGKPKLFIVQACRGRKLDRGVQLRAKLIQADCAKDVVDSQSVVYTYPEFA 196
Query: 703 DFLIVFSTVPGYYSWRNTTRGSWV 774
D L+V S+ G+YS+RN T GSW+
Sbjct: 197 DLLLVMSSHHGHYSFRNET-GSWL 219
Score = 34.7 bits (76), Expect = 3.0
Identities = 25/73 (34%), Positives = 37/73 (50%), Gaps = 5/73 (6%)
Frame = +2
Query: 290 FEIHNLKSRTGTNVDSDSLSKVLRGLGF---SVTVLHNLRAEDINRYIQQISEMDHT--D 454
FE + R GT+ D + L VL LGF + V + +I R ++ E+D
Sbjct: 46 FEDTSYDERCGTHKDVERLFHVLPRLGFLKEDIHVYEDYSYGEIQRAAMKL-ELDEELHQ 104
Query: 455 NDCLLVAVLSHGE 493
DCL+V +L+HGE
Sbjct: 105 ADCLMVFILTHGE 117
>UniRef50_A3QVU6 Cluster: Initiator caspase; n=3; Culicidae|Rep:
Initiator caspase - Aedes aegypti (Yellowfever mosquito)
Length = 493
Score = 59.7 bits (138), Expect = 9e-08
Identities = 32/77 (41%), Positives = 45/77 (58%), Gaps = 1/77 (1%)
Frame = +1
Query: 574 LAGKPKLFFIQACQGDKLDGGITLS-NTETDGXXXXXYRIPIHADFLIVFSTVPGYYSWR 750
L GKPKL F+QACQG L + ++ E DG ++ DFL+ +STVPG+ S R
Sbjct: 366 LTGKPKLLFVQACQGSGLQTAVDVAPRLEHDGPSSET-TASVYVDFLVAWSTVPGFASIR 424
Query: 751 NTTRGSWVYAISFVEEL 801
+ +GSW F++EL
Sbjct: 425 HIEKGSW-----FIQEL 436
Score = 43.2 bits (97), Expect = 0.008
Identities = 20/68 (29%), Positives = 37/68 (54%)
Frame = +2
Query: 305 LKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQISEMDHTDNDCLLVAVLS 484
LK+R GT VD ++ + LG+ V+ N+ +I ++Q + + L++ +LS
Sbjct: 278 LKNRRGTEVDKTAILNLFTNLGYEPIVVENIPHLEIMNQVEQAVDRVEPHHCSLVICLLS 337
Query: 485 HGELGMLY 508
HG+ G +Y
Sbjct: 338 HGQEGKVY 345
>UniRef50_UPI00015B59A2 Cluster: PREDICTED: similar to
ecdysone-inducible caspase, putative; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to
ecdysone-inducible caspase, putative - Nasonia
vitripennis
Length = 438
Score = 59.3 bits (137), Expect = 1e-07
Identities = 29/87 (33%), Positives = 44/87 (50%), Gaps = 9/87 (10%)
Frame = +1
Query: 550 FTADKCPTLAGKPKLFFIQACQGDK---------LDGGITLSNTETDGXXXXXYRIPIHA 702
FTA +CP+L KPK+F Q C+GDK + +D + ++
Sbjct: 287 FTAMQCPSLINKPKIFIFQTCRGDKHQQAVVSRFATDAVVTKEASSDSHKPFGVSMRNYS 346
Query: 703 DFLIVFSTVPGYYSWRNTTRGSWVYAI 783
D +I ++T+PGY S+R+T GSW I
Sbjct: 347 DTIIAYATLPGYVSYRDTHNGSWFIQI 373
Score = 39.1 bits (87), Expect = 0.14
Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 1/79 (1%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
RG+ ++ + ++I L R D D+L+ + +GF V NL +I + +++ S
Sbjct: 178 RGLVLMITNIDYKI--LDRRPSAKYDEDNLTNLFEEMGFRVIKYKNLTGNEIKKKVREFS 235
Query: 437 EMDHTDN-DCLLVAVLSHG 490
+M D + V + SHG
Sbjct: 236 QMKELARVDSVFVIISSHG 254
>UniRef50_A7SXL6 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 180
Score = 59.3 bits (137), Expect = 1e-07
Identities = 32/76 (42%), Positives = 39/76 (51%)
Frame = +1
Query: 532 DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFL 711
D + F CP LA KPKLFFIQAC+GD +D G + +P ADFL
Sbjct: 24 DEITGKFQGTNCPQLATKPKLFFIQACRGDDVDKGYR-GHRNHHHEEELPVTLPSEADFL 82
Query: 712 IVFSTVPGYYSWRNTT 759
I +ST G S+R T
Sbjct: 83 IAYSTTKGKVSFRRYT 98
>UniRef50_Q4FJK5 Cluster: Casp9 protein; n=20; Eutheria|Rep: Casp9
protein - Mus musculus (Mouse)
Length = 454
Score = 58.4 bits (135), Expect = 2e-07
Identities = 34/96 (35%), Positives = 47/96 (48%), Gaps = 22/96 (22%)
Frame = +1
Query: 550 FTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDG--------XXXXXYR------ 687
F CP+L GKPKLFFIQAC G++ D G ++ T + G Y+
Sbjct: 305 FNGSGCPSLGGKPKLFFIQACGGEQKDHGFEVACTSSQGRTLDSDSEPDAVPYQEGPRPL 364
Query: 688 --------IPIHADFLIVFSTVPGYYSWRNTTRGSW 771
+P +D L+ +ST PG+ SWR+ GSW
Sbjct: 365 DQLDAVSSLPTPSDILVSYSTFPGFVSWRDKKSGSW 400
Score = 51.2 bits (117), Expect = 3e-05
Identities = 27/78 (34%), Positives = 44/78 (56%), Gaps = 1/78 (1%)
Frame = +2
Query: 260 GMAIIFNHEHF-EIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
G +I N+ +F L +RTG+N+D D L R L F V V ++L A+ + + +++
Sbjct: 199 GHCLIINNVNFCPSSGLGTRTGSNLDRDKLEHRFRWLRFMVEVKNDLTAKKMVTALMEMA 258
Query: 437 EMDHTDNDCLLVAVLSHG 490
+H DC +V +LSHG
Sbjct: 259 HRNHRALDCFVVVILSHG 276
>UniRef50_UPI000065FEF6 Cluster: Homolog of Ictalurus punctatus
"Caspase 8.; n=1; Takifugu rubripes|Rep: Homolog of
Ictalurus punctatus "Caspase 8. - Takifugu rubripes
Length = 340
Score = 58.0 bits (134), Expect = 3e-07
Identities = 33/84 (39%), Positives = 44/84 (52%)
Frame = +1
Query: 550 FTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFLIVFSTV 729
F A + L KPK+F IQACQG G+ L + +TD IP AD L+ +TV
Sbjct: 211 FKATRQSALVSKPKMFLIQACQGKGTHRGVLLKDLQTD--DCHTLSIPEEADILVATATV 268
Query: 730 PGYYSWRNTTRGSWVYAISFVEEL 801
Y S+R+ GSW + S +EL
Sbjct: 269 EDYVSFRHKIDGSW-FIQSLCQEL 291
Score = 52.4 bits (120), Expect = 1e-05
Identities = 28/81 (34%), Positives = 47/81 (58%)
Frame = +2
Query: 251 QYRGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQ 430
Q G+ +I N+E+F ++K R+GTN D+ SL++V LGF V + + E ++R
Sbjct: 113 QPTGLCVIINNENFL--DMKQRSGTNKDAQSLAEVFTWLGFRVLMCKDQTKEKMDRAFVD 170
Query: 431 ISEMDHTDNDCLLVAVLSHGE 493
+ ++D D + +LSHGE
Sbjct: 171 L-QVDPKHGDAFICCILSHGE 190
>UniRef50_Q9IB64 Cluster: Caspase-8; n=1; Xenopus laevis|Rep:
Caspase-8 - Xenopus laevis (African clawed frog)
Length = 500
Score = 58.0 bits (134), Expect = 3e-07
Identities = 36/91 (39%), Positives = 46/91 (50%), Gaps = 4/91 (4%)
Frame = +1
Query: 547 YFTADKCPTLAGKPKLFFIQACQG----DKLDGGITLSNTETDGXXXXXYRIPIHADFLI 714
YF C +L KPK+FFIQACQG K+D + S E D +P+ ADFL
Sbjct: 363 YFNGQHCRSLINKPKIFFIQACQGKESHPKVDMDMDTSFYEPDANGS---HLPLEADFLT 419
Query: 715 VFSTVPGYYSWRNTTRGSWVYAISFVEELXT 807
F+TV Y S R+ GS +Y + L T
Sbjct: 420 AFATVEDYTSLRHRENGS-IYIQQLCKALTT 449
Score = 42.3 bits (95), Expect = 0.015
Identities = 17/62 (27%), Positives = 34/62 (54%)
Frame = +2
Query: 314 RTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQISEMDHTDNDCLLVAVLSHGE 493
R GT D++ ++++ G+ +L A +I + ++ S+ DH + D + +LSHG
Sbjct: 284 REGTAKDAEEITRIFNARGYITEEHRDLTAANIQKTLEMYSKKDHAEKDSFVCFILSHGG 343
Query: 494 LG 499
+G
Sbjct: 344 VG 345
>UniRef50_A7S9L1 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 262
Score = 57.6 bits (133), Expect = 4e-07
Identities = 36/86 (41%), Positives = 49/86 (56%), Gaps = 13/86 (15%)
Frame = +1
Query: 550 FTADKCPTLAGKPKLFFIQACQGDKLD-GGITLSNTET-DGXXXXXYRIPIH-------- 699
F+ +C +LAGKPKLFFIQAC+G+K D G I +T + Y+ +
Sbjct: 116 FSNARCRSLAGKPKLFFIQACRGEKKDFGTIVQDGPKTPEEHQETPYKFDLSPHNKGAST 175
Query: 700 ---ADFLIVFSTVPGYYSWRNTTRGS 768
ADFL+ +STV G+ S+RNT GS
Sbjct: 176 AEMADFLLAYSTVGGHASFRNTADGS 201
Score = 40.7 bits (91), Expect = 0.045
Identities = 22/91 (24%), Positives = 48/91 (52%), Gaps = 7/91 (7%)
Frame = +2
Query: 257 RGMAIIFNHEHFEI------HNLKSRTGTNVDSDSLSKVLRGLGFSVTVLH-NLRAEDIN 415
+G A+IFN++ F+ R G++ D+ SL ++ + F V + +L ++
Sbjct: 10 KGYAVIFNYKKFDSSLKFPSEKFDERLGSDKDTASLVRLWKAYDFEVPEPYLDLSYDETK 69
Query: 416 RYIQQISEMDHTDNDCLLVAVLSHGELGMLY 508
+ +++ D++ DCL + ++SHG+ +Y
Sbjct: 70 AAVNKLALKDYSQYDCLAIFLMSHGKEDFIY 100
>UniRef50_Q0PKX0 Cluster: Caspase Xa; n=4; Danio rerio|Rep: Caspase
Xa - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 345
Score = 57.2 bits (132), Expect = 5e-07
Identities = 35/81 (43%), Positives = 40/81 (49%), Gaps = 7/81 (8%)
Frame = +1
Query: 550 FTADKCPTLAGKPKLFFIQACQG-------DKLDGGITLSNTETDGXXXXXYRIPIHADF 708
FT C L GKPKLFFIQAC+G + G S E DG IP DF
Sbjct: 208 FTGINCQKLVGKPKLFFIQACRGLRKQLCVNAQADGDGESEMEVDG-DDFEITIPSDTDF 266
Query: 709 LIVFSTVPGYYSWRNTTRGSW 771
LI ST G+ S+R +GSW
Sbjct: 267 LIARSTTDGHLSYREPDKGSW 287
Score = 52.0 bits (119), Expect = 2e-05
Identities = 28/78 (35%), Positives = 41/78 (52%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
RG+ +I N+ F ++K R G++ D L+KV R LGF V N A ++ +Q +
Sbjct: 113 RGICVIINNVDFT--SMKERRGSDEDQKYLAKVFRWLGFEVVAHRNKTAAEMKNILQALG 170
Query: 437 EMDHTDNDCLLVAVLSHG 490
D DC + VLSHG
Sbjct: 171 RT--VDGDCFVCCVLSHG 186
>UniRef50_Q4JQQ0 Cluster: Initiator caspase; n=2; Gallus gallus|Rep:
Initiator caspase - Gallus gallus (Chicken)
Length = 464
Score = 56.4 bits (130), Expect = 8e-07
Identities = 35/94 (37%), Positives = 49/94 (52%), Gaps = 5/94 (5%)
Frame = +1
Query: 550 FTADKCPTLAGKPKLFFIQACQGDKLDGGITL-----SNTETDGXXXXXYRIPIHADFLI 714
F+ CP+LAGKPKLFFIQACQG +T+ + ETD IP AD L+
Sbjct: 321 FSGSNCPSLAGKPKLFFIQACQGSVGHPAVTVKEDCSGHLETDA--IPALSIPDQADVLV 378
Query: 715 VFSTVPGYYSWRNTTRGSWVYAISFVEELXTMGP 816
+TV + +R+ GS VY +++ + P
Sbjct: 379 GMATVEDFECYRSIETGS-VYIQCLCDKMELLCP 411
Score = 53.2 bits (122), Expect = 8e-06
Identities = 27/82 (32%), Positives = 45/82 (54%)
Frame = +2
Query: 260 GMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQISE 439
G +I N+ F+ N ++R GT D +L +V + L F +L A+ I + + S+
Sbjct: 224 GYCVILNNYRFKNPN-ETRKGTVEDGKALKRVFKWLQFDTIEYMDLEAKQIFAKVNEYSK 282
Query: 440 MDHTDNDCLLVAVLSHGELGML 505
DH++ DC + +LSHGE G +
Sbjct: 283 KDHSNMDCFVCFILSHGEKGKI 304
>UniRef50_Q2HZ04 Cluster: ICE-5; n=3; Bombyx mori|Rep: ICE-5 -
Bombyx mori (Silk moth)
Length = 312
Score = 56.4 bits (130), Expect = 8e-07
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 6/86 (6%)
Frame = +2
Query: 269 IIFNH------EHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQ 430
IIFNH ++F+ +R GT D SL + GL ++VT +L EDI + +
Sbjct: 52 IIFNHYTFKKTKYFQYKQPSTRNGTFEDVKSLKDLFEGLSYNVTTYTDLIYEDILNRVAE 111
Query: 431 ISEMDHTDNDCLLVAVLSHGELGMLY 508
+ DH+ C++V +L+HG+ G ++
Sbjct: 112 FCQRDHSKTSCVIVTILTHGDSGEVF 137
Score = 52.8 bits (121), Expect = 1e-05
Identities = 26/53 (49%), Positives = 34/53 (64%)
Frame = +1
Query: 571 TLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFLIVFSTV 729
TL GKPK+FFIQAC+G +D G T+ DG R+P H+DFL + S+V
Sbjct: 158 TLVGKPKIFFIQACRGPFMDEGRTV---VLDGESRSVLRLPTHSDFLFLHSSV 207
>UniRef50_P31944 Cluster: Caspase-14 precursor (EC 3.4.22.-)
(CASP-14) [Contains: Caspase-14 subunit 1; Caspase-14
subunit 2]; n=14; Mammalia|Rep: Caspase-14 precursor (EC
3.4.22.-) (CASP-14) [Contains: Caspase-14 subunit 1;
Caspase-14 subunit 2] - Homo sapiens (Human)
Length = 242
Score = 56.4 bits (130), Expect = 8e-07
Identities = 30/82 (36%), Positives = 44/82 (53%), Gaps = 1/82 (1%)
Frame = +1
Query: 526 KPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTE-TDGXXXXXYRIPIHA 702
K +NL+ C L KPK++ IQAC+G++ D G T+ E IP +
Sbjct: 104 KLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDEIVMVIKDSPQTIPTYT 163
Query: 703 DFLIVFSTVPGYYSWRNTTRGS 768
D L V+STV GY ++R+ +GS
Sbjct: 164 DALHVYSTVEGYIAYRHDQKGS 185
>UniRef50_P55211 Cluster: Caspase-9 precursor (EC 3.4.22.62)
(CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6)
(Apoptotic protease Mch-6) (Apoptotic protease-
activating factor 3) (APAF-3) [Contains: Caspase-9
subunit p35; Caspase-9 subunit p10]; n=23;
Tetrapoda|Rep: Caspase-9 precursor (EC 3.4.22.62)
(CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6)
(Apoptotic protease Mch-6) (Apoptotic protease-
activating factor 3) (APAF-3) [Contains: Caspase-9
subunit p35; Caspase-9 subunit p10] - Homo sapiens
(Human)
Length = 416
Score = 56.4 bits (130), Expect = 8e-07
Identities = 34/96 (35%), Positives = 44/96 (45%), Gaps = 22/96 (22%)
Frame = +1
Query: 550 FTADKCPTLAGKPKLFFIQACQGDKLDGGITL-----------SNTETDG---------- 666
F CP+L GKPKLFFIQAC G++ D G + SN E D
Sbjct: 267 FNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTF 326
Query: 667 -XXXXXYRIPIHADFLIVFSTVPGYYSWRNTTRGSW 771
+P +D + +ST PG+ SWR+ GSW
Sbjct: 327 DQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSW 362
Score = 51.6 bits (118), Expect = 2e-05
Identities = 26/78 (33%), Positives = 45/78 (57%), Gaps = 1/78 (1%)
Frame = +2
Query: 260 GMAIIFNHEHF-EIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
G +I N+ +F L++RTG+N+D + L + L F V V +L A+ + + +++
Sbjct: 161 GHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELA 220
Query: 437 EMDHTDNDCLLVAVLSHG 490
+ DH DC +V +LSHG
Sbjct: 221 QQDHGALDCCVVVILSHG 238
>UniRef50_Q9Y1U6 Cluster: Cell death protein CED-3; n=1;
Pristionchus pacificus|Rep: Cell death protein CED-3 -
Pristionchus pacificus
Length = 417
Score = 56.0 bits (129), Expect = 1e-06
Identities = 35/105 (33%), Positives = 51/105 (48%), Gaps = 11/105 (10%)
Frame = +1
Query: 514 DTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETD---------- 663
D HY L F P LAGKPK+ +QAC+G++ D G +++
Sbjct: 263 DVHY----LLSSFNTHNAPHLAGKPKIILLQACRGERKDIGYEETDSGRPFAFLECLGMG 318
Query: 664 -GXXXXXYRIPIHADFLIVFSTVPGYYSWRNTTRGSWVYAISFVE 795
G + P +D L+ ++T Y SWRN+ +GSW + SFVE
Sbjct: 319 GGGMMTRNKRPAESDILVAYATPAHYVSWRNSEKGSW-FIQSFVE 362
Score = 48.4 bits (110), Expect = 2e-04
Identities = 28/86 (32%), Positives = 46/86 (53%), Gaps = 2/86 (2%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKV-LRGLGFSVTVLHNLRAEDINRYIQQI 433
RG A+I ++EHF + R GT D +L + + LG+ V V NL ++++ I+
Sbjct: 172 RGYALIISNEHFR--TMPQRRGTKADVIALKNLFISKLGYEVEVHENLTGKELHNNIKSF 229
Query: 434 -SEMDHTDNDCLLVAVLSHGELGMLY 508
S H+ +V +L+HGE +LY
Sbjct: 230 ASSTKHSFTSSAIVCILTHGEHDVLY 255
>UniRef50_UPI0000F1EBE3 Cluster: PREDICTED: similar to caspase 10;
n=2; Danio rerio|Rep: PREDICTED: similar to caspase 10 -
Danio rerio
Length = 306
Score = 55.6 bits (128), Expect = 1e-06
Identities = 39/123 (31%), Positives = 60/123 (48%), Gaps = 8/123 (6%)
Frame = +1
Query: 472 CCVESW-RIRYVVSKDTHYKP-DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGI-- 639
CC+ S R+ ++ D P L + +C +L KPKLFFIQAC+G + +
Sbjct: 137 CCILSHGRLNDIIGVDGKAVPFKELMETLSPFRCSSLYQKPKLFFIQACRGTQNQRAVFP 196
Query: 640 -TLSNTE---TDGXXXXXYRIPIHADFLIVFSTVPGYYSWRNTTRGSWVYAISFVEELXT 807
T + E IP AD+L+ STVP Y S+R+ ++G+W + S + L
Sbjct: 197 QTFTEDEDVLASDAGVPRDSIPEMADYLMAMSTVPWYASYRDKSKGTW-FIQSLCDNLRL 255
Query: 808 MGP 816
+ P
Sbjct: 256 LVP 258
Score = 50.4 bits (115), Expect = 6e-05
Identities = 29/93 (31%), Positives = 44/93 (47%), Gaps = 13/93 (13%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVD-------------SDSLSKVLRGLGFSVTVLHNL 397
RG+ +I N+ F +R GT++D SDSL V LGF + +
Sbjct: 53 RGVCLIINNYDFSACGWLNREGTDIDHAPVSKCVLFYVYSDSLRDVFEWLGFEILTRRDC 112
Query: 398 RAEDINRYIQQISEMDHTDNDCLLVAVLSHGEL 496
+ I + + +S DHT DC++ +LSHG L
Sbjct: 113 TGDQILQALMDLSTQDHTQADCVVCCILSHGRL 145
>UniRef50_P42573 Cluster: Cell death protein 3 precursor (EC
3.4.22.-) [Contains: Cell death protein 3 subunit 1;
Cell death protein 3 subunit 2]; n=3;
Caenorhabditis|Rep: Cell death protein 3 precursor (EC
3.4.22.-) [Contains: Cell death protein 3 subunit 1;
Cell death protein 3 subunit 2] - Caenorhabditis elegans
Length = 503
Score = 54.4 bits (125), Expect = 3e-06
Identities = 27/79 (34%), Positives = 46/79 (58%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
RGM +I N+EHFE + +R GT D D+L+ + R +G++V NL + I+ +
Sbjct: 242 RGMCLIINNEHFE--QMPTRNGTKADKDNLTNLFRCMGYTVICKDNLTGRGMLLTIRDFA 299
Query: 437 EMDHTDNDCLLVAVLSHGE 493
+ + + D ++ +LSHGE
Sbjct: 300 KHE-SHGDSAILVILSHGE 317
Score = 43.6 bits (98), Expect = 0.006
Identities = 31/97 (31%), Positives = 39/97 (40%), Gaps = 25/97 (25%)
Frame = +1
Query: 556 ADKCPTLAGKPKLFFIQACQG----------DKLDGGITLSNTETDGXXXXXYRI----- 690
A P LA KPK+ F+QAC+G D +DG D +
Sbjct: 340 AANAPRLANKPKIVFVQACRGERRDNGFPVLDSVDGVPAFLRRGWDNRDGPLFNFLGCVR 399
Query: 691 ----------PIHADFLIVFSTVPGYYSWRNTTRGSW 771
P AD LI ++T Y SWRN+ RGSW
Sbjct: 400 PQVQQVWRKKPSQADILIAYATTAQYVSWRNSARGSW 436
>UniRef50_P42575 Cluster: Caspase-2 precursor (EC 3.4.22.55)
(CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural
precursor cell expressed developmentally down- regulated
protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18;
Caspase-2 subunit p13; Caspase-2 subunit p12]; n=34;
Euteleostomi|Rep: Caspase-2 precursor (EC 3.4.22.55)
(CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural
precursor cell expressed developmentally down- regulated
protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18;
Caspase-2 subunit p13; Caspase-2 subunit p12] - Homo
sapiens (Human)
Length = 452
Score = 54.4 bits (125), Expect = 3e-06
Identities = 30/86 (34%), Positives = 44/86 (51%), Gaps = 12/86 (13%)
Frame = +1
Query: 550 FTADKCPTLAGKPKLFFIQACQGDKLDGGITLSN----------TETDGXXXXX--YRIP 693
F CP+L KPK+FFIQAC+GD+ D G+ + E+D R+P
Sbjct: 300 FDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLP 359
Query: 694 IHADFLIVFSTVPGYYSWRNTTRGSW 771
+D + ++ + G + RNT RGSW
Sbjct: 360 TRSDMICGYACLKGTAAMRNTKRGSW 385
Score = 52.0 bits (119), Expect = 2e-05
Identities = 28/86 (32%), Positives = 51/86 (59%), Gaps = 2/86 (2%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHN-LKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQI 433
RG+A++ ++ HF L+ R+G +VD +L + + LG+ V VL + A+++ +Q
Sbjct: 199 RGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNF 258
Query: 434 SEMD-HTDNDCLLVAVLSHGELGMLY 508
+++ H D +VA+LSHG G +Y
Sbjct: 259 AQLPAHRVTDSCIVALLSHGVEGAIY 284
>UniRef50_Q3T2L0 Cluster: Caspase-15; n=11; Theria|Rep: Caspase-15 -
Bos taurus (Bovine)
Length = 368
Score = 53.6 bits (123), Expect = 6e-06
Identities = 25/80 (31%), Positives = 42/80 (52%), Gaps = 1/80 (1%)
Frame = +1
Query: 532 DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETD-GXXXXXYRIPIHADF 708
++++ F CP L KPK+F IQAC+G++ D G+ + D R+P +D+
Sbjct: 231 EDIFEMFNNKNCPALQEKPKIFIIQACRGERRDSGVETDDEPMDLDDGSEKKRLPTFSDY 290
Query: 709 LIVFSTVPGYYSWRNTTRGS 768
IV+ T + + R+ GS
Sbjct: 291 FIVYPTQADHVALRDPRTGS 310
>UniRef50_Q9Y055 Cluster: Caspase-related protein 2A; n=3;
Caenorhabditis elegans|Rep: Caspase-related protein 2A -
Caenorhabditis elegans
Length = 826
Score = 53.6 bits (123), Expect = 6e-06
Identities = 27/81 (33%), Positives = 48/81 (59%)
Frame = +2
Query: 266 AIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQISEMD 445
AII N+ F ++ R G++ D LSK+ LG+ T NL++ +I ++Q ++ +
Sbjct: 591 AIIINNVVF--CGMEKRIGSDKDKKKLSKLFERLGYQSTSYDNLKSSEILETVRQFTQSN 648
Query: 446 HTDNDCLLVAVLSHGELGMLY 508
H D L++ ++SHG+ G+LY
Sbjct: 649 H--GDSLIITIMSHGDQGLLY 667
Score = 38.7 bits (86), Expect = 0.18
Identities = 25/80 (31%), Positives = 39/80 (48%), Gaps = 13/80 (16%)
Frame = +1
Query: 571 TLAGKPKLFFIQACQGDKLDGGIT----LSNTETDGXXXXXY---RIPIH------ADFL 711
+LA KPK C+GD++D + + N + + P H AD L
Sbjct: 687 SLAKKPKWLMCVCCRGDRIDRAVRCDGFIDNFFDRFPKFFQFMKSKFPSHQTSSSQADLL 746
Query: 712 IVFSTVPGYYSWRNTTRGSW 771
+ FST PG+ S+R+ T+G+W
Sbjct: 747 VSFSTSPGFLSFRDETKGTW 766
>UniRef50_P55865 Cluster: Caspase-1-A precursor; n=3; Xenopus|Rep:
Caspase-1-A precursor - Xenopus laevis (African clawed
frog)
Length = 386
Score = 52.8 bits (121), Expect = 1e-05
Identities = 26/80 (32%), Positives = 48/80 (60%), Gaps = 1/80 (1%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
+G+A+I +E FE NL R G VD D ++K+L LG+ V NL ++ + +++ +
Sbjct: 143 KGLALIICNEKFE--NLNERHGAKVDLDGMTKLLNELGYQVHPHTNLTKTEMVKVMKEFA 200
Query: 437 -EMDHTDNDCLLVAVLSHGE 493
+ +H D+D + ++SHG+
Sbjct: 201 AQEEHADSDSTFIVLMSHGD 220
Score = 47.2 bits (107), Expect = 5e-04
Identities = 26/91 (28%), Positives = 44/91 (48%), Gaps = 1/91 (1%)
Frame = +1
Query: 532 DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDG-XXXXXYRIPIHADF 708
D ++ F C L KPK+ IQAC+G+ G + + + + + ADF
Sbjct: 248 DEIFSTFNNVNCSKLRNKPKVIIIQACRGENKGGLLVRDDVASPPLEDDGLHFVQREADF 307
Query: 709 LIVFSTVPGYYSWRNTTRGSWVYAISFVEEL 801
+ S+ P SWR+ T+GS V+ +E++
Sbjct: 308 ICFCSSTPDTVSWRDPTKGS-VFITHLIEKM 337
>UniRef50_Q9GV89 Cluster: Caspase 3A; n=1; Hydra vulgaris|Rep:
Caspase 3A - Hydra attenuata (Hydra) (Hydra vulgaris)
Length = 347
Score = 52.4 bits (120), Expect = 1e-05
Identities = 30/99 (30%), Positives = 48/99 (48%)
Frame = +1
Query: 505 VSKDTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXY 684
+ K ++L F AD P KPK+F +QAC+G+K D +
Sbjct: 176 IDSSEEIKINSLLENFKADNAPAFDKKPKVFIVQACRGEK-DDIRKDGIKDAKRTYYNES 234
Query: 685 RIPIHADFLIVFSTVPGYYSWRNTTRGSWVYAISFVEEL 801
IP+ +DF++ + GY + R+T +GSW F++EL
Sbjct: 235 TIPMLSDFVVAYPCAAGYTALRSTVKGSW-----FIQEL 268
Score = 45.6 bits (103), Expect = 0.002
Identities = 28/84 (33%), Positives = 46/84 (54%), Gaps = 2/84 (2%)
Frame = +2
Query: 260 GMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRG-LGFSVTVLHNLRAEDINRYIQQIS 436
G +I N+E F ++R G+ VD +L+ +G LG+ V +NL+ EDI + +S
Sbjct: 93 GFVLIINNEKFVEE--ENRDGSEVDVQALNSFFKGTLGWCVKSCNNLKREDIINIVYSLS 150
Query: 437 EMDHTDNDCLLVAVLSHG-ELGML 505
++ L + +LSHG E G+L
Sbjct: 151 QVKCFPFSALFIVILSHGSESGIL 174
>UniRef50_UPI0000F2DFE8 Cluster: PREDICTED: similar to initiator
caspase; n=1; Monodelphis domestica|Rep: PREDICTED:
similar to initiator caspase - Monodelphis domestica
Length = 473
Score = 52.0 bits (119), Expect = 2e-05
Identities = 44/122 (36%), Positives = 58/122 (47%), Gaps = 5/122 (4%)
Frame = +1
Query: 472 CCVESWRIRYVVSKDTHYKP---DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGIT 642
CC+ S + VV T +KP L YFTA++C TL KPKLFFIQACQ K D +
Sbjct: 285 CCILSHGKKGVVL-GTDWKPVAIKKLLSYFTANECKTLKDKPKLFFIQACQNGKSD-SLP 342
Query: 643 LSNTETDGXXXXXYRIPIH--ADFLIVFSTVPGYYSWRNTTRGSWVYAISFVEELXTMGP 816
+ E D H +D I +TV + R+ + GS Y + +EL P
Sbjct: 343 EVDVEFDLEADAICSNTTHEWSDIFIGMATVEDSLAQRSGSIGS-PYIQNLCKELEAHCP 401
Query: 817 PK 822
K
Sbjct: 402 QK 403
Score = 49.2 bits (112), Expect = 1e-04
Identities = 26/82 (31%), Positives = 43/82 (52%)
Frame = +2
Query: 260 GMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQISE 439
G +I ++ HF + + R GT D +L KV L F NL A ++ ++ S+
Sbjct: 216 GYVVIIDNIHFS-NPVDVRIGTEKDVAALRKVFGRLQFKEKYHSNLDASQLHEVMKDYSK 274
Query: 440 MDHTDNDCLLVAVLSHGELGML 505
D+TD D + +LSHG+ G++
Sbjct: 275 RDYTDQDAFICCILSHGKKGVV 296
>UniRef50_UPI0000E45DDA Cluster: PREDICTED: similar to caspase 3;
n=1; Strongylocentrotus purpuratus|Rep: PREDICTED:
similar to caspase 3 - Strongylocentrotus purpuratus
Length = 526
Score = 52.0 bits (119), Expect = 2e-05
Identities = 36/106 (33%), Positives = 48/106 (45%), Gaps = 22/106 (20%)
Frame = +1
Query: 550 FTADKCPTLAGKPKLFFIQACQG----------------------DKLDGGITLSNTETD 663
F+ +CP L GKPK+FFIQAC+G D D S TD
Sbjct: 323 FSGRQCPALLGKPKIFFIQACRGQMRTKSALDTDDPRRLSPIEMVDDPDIDSCSSRRPTD 382
Query: 664 GXXXXXYRIPIHADFLIVFSTVPGYYSWRNTTRGSWVYAISFVEEL 801
+P +AD + ++T GY+S RN +GSW + S EEL
Sbjct: 383 DAVDIDGDVPDNADIYVAYATSEGYFSIRNQVKGSW-FIQSLCEEL 427
>UniRef50_Q504J1 Cluster: Caspase b; n=7; Danio rerio|Rep: Caspase b
- Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 404
Score = 51.2 bits (117), Expect = 3e-05
Identities = 25/81 (30%), Positives = 45/81 (55%), Gaps = 1/81 (1%)
Frame = +2
Query: 251 QYRGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQ 430
Q +G+A++ + F + +R G + D ++ +LR LGF+V NL +DI R ++
Sbjct: 171 QRKGLALLITNIQFA-NTQHNRNGADRDEENAEWLLRSLGFAVIKYRNLSGKDIRRAVEN 229
Query: 431 ISEM-DHTDNDCLLVAVLSHG 490
S+ +H D D + ++SHG
Sbjct: 230 FSKRREHEDADSTFIVIMSHG 250
Score = 45.6 bits (103), Expect = 0.002
Identities = 27/99 (27%), Positives = 49/99 (49%)
Frame = +1
Query: 505 VSKDTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXY 684
VS D ++ + + + + CP L KPK+ IQAC+G + G + D
Sbjct: 262 VSDDVYFIEET-FSHLNSVNCPALIDKPKVILIQACRGGQSSGVLA-----QDSVFASDS 315
Query: 685 RIPIHADFLIVFSTVPGYYSWRNTTRGSWVYAISFVEEL 801
+ + DF+ ST+P +++RN GS + IS++ ++
Sbjct: 316 WVHMEKDFVCFMSTMPNTFAYRNPIEGS--FFISYIVDV 352
>UniRef50_UPI00006A1E20 Cluster: Caspase-9 precursor (EC 3.4.22.62)
(CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6)
(Apoptotic protease Mch-6) (Apoptotic protease-
activating factor 3) (APAF-3) [Contains: Caspase-9
subunit p35; Caspase-9 subunit p10].; n=1; Xenopus
tropicalis|Rep: Caspase-9 precursor (EC 3.4.22.62)
(CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6)
(Apoptotic protease Mch-6) (Apoptotic protease-
activating factor 3) (APAF-3) [Contains: Caspase-9
subunit p35; Caspase-9 subunit p10]. - Xenopus
tropicalis
Length = 141
Score = 44.8 bits (101), Expect(2) = 1e-04
Identities = 17/24 (70%), Positives = 19/24 (79%)
Frame = +1
Query: 547 YFTADKCPTLAGKPKLFFIQACQG 618
YF KCP+L GKPK+FFIQAC G
Sbjct: 51 YFNGSKCPSLRGKPKIFFIQACGG 74
Score = 24.2 bits (50), Expect(2) = 1e-04
Identities = 8/13 (61%), Positives = 9/13 (69%)
Frame = +1
Query: 733 GYYSWRNTTRGSW 771
GY SWR+ GSW
Sbjct: 75 GYVSWRDKHTGSW 87
>UniRef50_UPI0000E82482 Cluster: PREDICTED: hypothetical protein;
n=2; Gallus gallus|Rep: PREDICTED: hypothetical protein
- Gallus gallus
Length = 266
Score = 49.2 bits (112), Expect = 1e-04
Identities = 25/84 (29%), Positives = 47/84 (55%), Gaps = 2/84 (2%)
Frame = +1
Query: 538 LWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIH--ADFL 711
+++ +A CP LA +PK+FFIQAC+G LD G+ + T++ + +H +
Sbjct: 103 IFHIVSAQNCPALAERPKVFFIQACRGAALDQGVFV-ETDSGQPEPASFSEYLHIPPNTA 161
Query: 712 IVFSTVPGYYSWRNTTRGSWVYAI 783
++F+ PGY ++ N ++ A+
Sbjct: 162 VMFACSPGYGAFLNPAGSMFLQAL 185
Score = 41.5 bits (93), Expect = 0.026
Identities = 22/65 (33%), Positives = 35/65 (53%)
Frame = +2
Query: 305 LKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQISEMDHTDNDCLLVAVLS 484
L+ R G +++ LS+VL L + V +LHN A+++ QQ +H D + + S
Sbjct: 26 LRPRRGARREAEKLSRVLAQLSYRVKLLHNRTAKEMEDLYQQECSREH--GDYFVSVISS 83
Query: 485 HGELG 499
HGE G
Sbjct: 84 HGEEG 88
>UniRef50_UPI0000D56041 Cluster: PREDICTED: similar to CG7486-PB,
isoform B; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG7486-PB, isoform B - Tribolium castaneum
Length = 568
Score = 49.2 bits (112), Expect = 1e-04
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 2/70 (2%)
Frame = +1
Query: 568 PTLAGKPKLFFIQACQGDKLDG-GITLSNTETDGXXXXXYR-IPIHADFLIVFSTVPGYY 741
P L+GKPK+ +Q+CQG + + ETDG +P AD ++TVPGY
Sbjct: 437 PHLSGKPKVLILQSCQGTRCQKIQSDDDDIETDGPSSPVQESVPPIADLFTFWATVPGYG 496
Query: 742 SWRNTTRGSW 771
+ RN GSW
Sbjct: 497 AIRNKKTGSW 506
>UniRef50_UPI00015B57F0 Cluster: PREDICTED: similar to GA20532-PA;
n=1; Nasonia vitripennis|Rep: PREDICTED: similar to
GA20532-PA - Nasonia vitripennis
Length = 1390
Score = 48.4 bits (110), Expect = 2e-04
Identities = 26/66 (39%), Positives = 37/66 (56%), Gaps = 6/66 (9%)
Frame = +1
Query: 571 TLAGKPKLFFIQACQGDKLDGGI------TLSNTETDGXXXXXYRIPIHADFLIVFSTVP 732
+L KPK+FFIQAC+G ++D GI T S E DG ++ I AD +S+ P
Sbjct: 290 SLINKPKIFFIQACRGPQIDKGICSNEVNTSSEDEVDGNEVFT-KVSIKADIFKAYSSPP 348
Query: 733 GYYSWR 750
+ SW+
Sbjct: 349 DFVSWQ 354
>UniRef50_UPI0000E47913 Cluster: PREDICTED: similar to cysteine
protease CPP32 isoform alpha; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to cysteine protease
CPP32 isoform alpha - Strongylocentrotus purpuratus
Length = 505
Score = 48.4 bits (110), Expect = 2e-04
Identities = 36/112 (32%), Positives = 52/112 (46%), Gaps = 15/112 (13%)
Frame = +1
Query: 511 KDTHYKPDNLWYY-------FTADKCPTLAGKPKLFFIQACQGDKLDGGITLS------- 648
KD DN W F D+ P + KPK+F IQ+C+G + G++ S
Sbjct: 344 KDAVLMADNKWMLVEDIISNFHGDQIPKMQDKPKVFIIQSCRGKEKQRGVSSSDGPATEL 403
Query: 649 NTET-DGXXXXXYRIPIHADFLIVFSTVPGYYSWRNTTRGSWVYAISFVEEL 801
N ET D P+++D LI ++T ++RN GSW FVE+L
Sbjct: 404 NPETMDYPEPAVTTRPVNSDILIAYATSQSKKAFRNQDNGSW-----FVEDL 450
>UniRef50_Q28GK9 Cluster: Novel protein; n=1; Xenopus
tropicalis|Rep: Novel protein - Xenopus tropicalis
(Western clawed frog) (Silurana tropicalis)
Length = 239
Score = 47.6 bits (108), Expect = 4e-04
Identities = 22/74 (29%), Positives = 44/74 (59%), Gaps = 1/74 (1%)
Frame = +1
Query: 535 NLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITL-SNTETDGXXXXXYRIPIHADFL 711
+L+ + P LAG PKLFF+QAC+G++ D G+ L ++ +T + + D +
Sbjct: 99 DLYDILAPNNSPLLAGVPKLFFVQACRGEQFDEGVFLETDGDTCATDAFSLSLNLPRDSV 158
Query: 712 IVFSTVPGYYSWRN 753
++F++ G+ +++N
Sbjct: 159 LMFASSEGHVAFQN 172
Score = 42.3 bits (95), Expect = 0.015
Identities = 24/78 (30%), Positives = 42/78 (53%)
Frame = +2
Query: 275 FNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQISEMDHTD 454
F+ H E+ +L R G D + L KVL LG+ V++ ++ A++I Q+ S+M
Sbjct: 13 FHPRHGEVGSLDQRKGVKRDVNRLFKVLSRLGYKVSLHMDVSAKEIKDIYQKESKM--PQ 70
Query: 455 NDCLLVAVLSHGELGMLY 508
+ + + SHG G++Y
Sbjct: 71 GESFISILSSHGNEGLIY 88
>UniRef50_UPI0000F1EFFE Cluster: PREDICTED: hypothetical protein;
n=4; Danio rerio|Rep: PREDICTED: hypothetical protein -
Danio rerio
Length = 277
Score = 46.8 bits (106), Expect = 7e-04
Identities = 27/72 (37%), Positives = 38/72 (52%), Gaps = 4/72 (5%)
Frame = +1
Query: 535 NLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITL----SNTETDGXXXXXYRIPIHA 702
NL ++ + P + K KLF IQAC+G LDGG+ L S++E IPI
Sbjct: 121 NLAEIYSCFRSPIMKDKSKLFLIQACRGGDLDGGVELETDSSSSEEQDILSELLSIPI-- 178
Query: 703 DFLIVFSTVPGY 738
D + ++T PGY
Sbjct: 179 DTAVTYATSPGY 190
Score = 44.0 bits (99), Expect = 0.005
Identities = 24/68 (35%), Positives = 39/68 (57%)
Frame = +2
Query: 305 LKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQISEMDHTDNDCLLVAVLS 484
L R G DS L K+L LGFSV + ++ AE+I + + +E + T +C + + S
Sbjct: 48 LCKRIGVKRDSRRLYKILSELGFSVDIRLDIEAEEIYQAFK--AESEQTVKECFVGIISS 105
Query: 485 HGELGMLY 508
HGE G+++
Sbjct: 106 HGEEGVVF 113
>UniRef50_P29466-4 Cluster: Isoform Delta of P29466 ; n=2;
Euarchontoglires|Rep: Isoform Delta of P29466 - Homo
sapiens (Human)
Length = 263
Score = 46.4 bits (105), Expect = 0.001
Identities = 24/77 (31%), Positives = 43/77 (55%), Gaps = 1/77 (1%)
Frame = +2
Query: 263 MAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQISEM 442
+A+I +E F+ ++ RTG VD ++ +L+ LG+SV V NL A D+ ++ +
Sbjct: 71 LALIICNEEFD--SIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHR 128
Query: 443 -DHTDNDCLLVAVLSHG 490
+H +D + +SHG
Sbjct: 129 PEHKTSDSTFLVFMSHG 145
Score = 33.5 bits (73), Expect = 6.8
Identities = 12/21 (57%), Positives = 16/21 (76%)
Frame = +1
Query: 565 CPTLAGKPKLFFIQACQGDKL 627
CP+L KPK+ IQAC+GD +
Sbjct: 177 CPSLKDKPKVIIIQACRGDNV 197
>UniRef50_P29466-2 Cluster: Isoform Beta of P29466 ; n=11;
Theria|Rep: Isoform Beta of P29466 - Homo sapiens
(Human)
Length = 383
Score = 46.4 bits (105), Expect = 0.001
Identities = 24/77 (31%), Positives = 43/77 (55%), Gaps = 1/77 (1%)
Frame = +2
Query: 263 MAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQISEM 442
+A+I +E F+ ++ RTG VD ++ +L+ LG+SV V NL A D+ ++ +
Sbjct: 143 LALIICNEEFD--SIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHR 200
Query: 443 -DHTDNDCLLVAVLSHG 490
+H +D + +SHG
Sbjct: 201 PEHKTSDSTFLVFMSHG 217
Score = 44.0 bits (99), Expect = 0.005
Identities = 27/79 (34%), Positives = 38/79 (48%), Gaps = 11/79 (13%)
Frame = +1
Query: 565 CPTLAGKPKLFFIQACQGDK-----------LDGGITLSNTETDGXXXXXYRIPIHADFL 711
CP+L KPK+ IQAC+GD + G ++L TE + + I DF+
Sbjct: 249 CPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTE-EFEDDAIKKAHIEKDFI 307
Query: 712 IVFSTVPGYYSWRNTTRGS 768
S+ P SWR+ T GS
Sbjct: 308 AFCSSTPDNVSWRHPTMGS 326
>UniRef50_P29466 Cluster: Caspase-1 precursor (EC 3.4.22.36)
(CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1
beta-converting enzyme) (ICE) (Interleukin- 1
beta-converting enzyme) (p45) [Contains: Caspase-1
subunit p20; Caspase-1 subunit p10]; n=29; Eutheria|Rep:
Caspase-1 precursor (EC 3.4.22.36) (CASP-1)
(Interleukin-1 beta convertase) (IL-1BC) (IL-1
beta-converting enzyme) (ICE) (Interleukin- 1
beta-converting enzyme) (p45) [Contains: Caspase-1
subunit p20; Caspase-1 subunit p10] - Homo sapiens
(Human)
Length = 404
Score = 46.4 bits (105), Expect = 0.001
Identities = 24/77 (31%), Positives = 43/77 (55%), Gaps = 1/77 (1%)
Frame = +2
Query: 263 MAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQISEM 442
+A+I +E F+ ++ RTG VD ++ +L+ LG+SV V NL A D+ ++ +
Sbjct: 164 LALIICNEEFD--SIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHR 221
Query: 443 -DHTDNDCLLVAVLSHG 490
+H +D + +SHG
Sbjct: 222 PEHKTSDSTFLVFMSHG 238
Score = 44.0 bits (99), Expect = 0.005
Identities = 27/79 (34%), Positives = 38/79 (48%), Gaps = 11/79 (13%)
Frame = +1
Query: 565 CPTLAGKPKLFFIQACQGDK-----------LDGGITLSNTETDGXXXXXYRIPIHADFL 711
CP+L KPK+ IQAC+GD + G ++L TE + + I DF+
Sbjct: 270 CPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTE-EFEDDAIKKAHIEKDFI 328
Query: 712 IVFSTVPGYYSWRNTTRGS 768
S+ P SWR+ T GS
Sbjct: 329 AFCSSTPDNVSWRHPTMGS 347
>UniRef50_Q9XYF4 Cluster: Caspase Nc precursor (EC 3.4.22.-)
(NEDD2-like caspase DRONC) [Contains: Caspase Nc subunit
1; Caspase Nc subunit 2]; n=2; Sophophora|Rep: Caspase
Nc precursor (EC 3.4.22.-) (NEDD2-like caspase DRONC)
[Contains: Caspase Nc subunit 1; Caspase Nc subunit 2] -
Drosophila melanogaster (Fruit fly)
Length = 450
Score = 46.0 bits (104), Expect = 0.001
Identities = 27/92 (29%), Positives = 41/92 (44%), Gaps = 17/92 (18%)
Frame = +1
Query: 547 YFTADKCPTLAGKPKLFFIQACQGDKLDGGITLS-----------------NTETDGXXX 675
+F KCP L KPK+ C+GD+ D G + +T+T+G
Sbjct: 297 HFQTAKCPYLVNKPKVLMFPFCRGDEYDLGHPKNQGNLMEPVYTAQEEKWPDTQTEGIPS 356
Query: 676 XXYRIPIHADFLIVFSTVPGYYSWRNTTRGSW 771
+P AD L+ ++ PGY + R+ GSW
Sbjct: 357 PSTNVPSLADTLVCYANTPGYVTHRDLDTGSW 388
>UniRef50_UPI0000E4A098 Cluster: PREDICTED: similar to CGI-141
protein; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to CGI-141 protein -
Strongylocentrotus purpuratus
Length = 225
Score = 45.6 bits (103), Expect = 0.002
Identities = 17/24 (70%), Positives = 22/24 (91%)
Frame = +1
Query: 550 FTADKCPTLAGKPKLFFIQACQGD 621
F++D CPTL GKPKLFF+QAC+G+
Sbjct: 74 FSSDLCPTLNGKPKLFFLQACRGE 97
>UniRef50_UPI000051A33A Cluster: PREDICTED: similar to CG6597-PA,
isoform A; n=2; Coelomata|Rep: PREDICTED: similar to
CG6597-PA, isoform A - Apis mellifera
Length = 478
Score = 45.6 bits (103), Expect = 0.002
Identities = 29/92 (31%), Positives = 47/92 (51%), Gaps = 9/92 (9%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSV---------TVLHNLRAED 409
RG A+IFN+ + + R T + +LS+ + +GF V ++ L++
Sbjct: 72 RGTALIFNN----VKIYQERNNTEACARNLSQTFQMMGFDVELIVDATLQVIIEKLKSAK 127
Query: 410 INRYIQQISEMDHTDNDCLLVAVLSHGELGML 505
+ +++ DHT+NDCL VAVLS G G L
Sbjct: 128 LINPFVKVASQDHTNNDCLAVAVLSTGTSGYL 159
Score = 37.5 bits (83), Expect = 0.42
Identities = 15/36 (41%), Positives = 20/36 (55%)
Frame = +1
Query: 499 YVVSKDTHYKPDNLWYYFTADKCPTLAGKPKLFFIQ 606
Y+ + + Y LW F D CP L KPK+FF+Q
Sbjct: 158 YLKADNMFYPAQMLWMPFLPDSCPGLIDKPKIFFLQ 193
>UniRef50_Q0Z8U7 Cluster: Caspase-8; n=1; Haemaphysalis
longicornis|Rep: Caspase-8 - Haemaphysalis longicornis
(Bush tick)
Length = 306
Score = 45.2 bits (102), Expect = 0.002
Identities = 26/85 (30%), Positives = 43/85 (50%), Gaps = 1/85 (1%)
Frame = +2
Query: 257 RGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 436
RG+ II N+ F + R G+ VD + + L F V +L A+D+ + +
Sbjct: 56 RGLCIIINNVDFG-NRFPKRHGSEVDVRRMEDLFEALFFRVQTHRDLSADDMKSVLSDAA 114
Query: 437 EMDHTDN-DCLLVAVLSHGELGMLY 508
+ D N +CL+V ++SHGE +Y
Sbjct: 115 KEDKQKNAECLVVILMSHGENDGIY 139
Score = 41.1 bits (92), Expect = 0.034
Identities = 16/27 (59%), Positives = 20/27 (74%)
Frame = +1
Query: 550 FTADKCPTLAGKPKLFFIQACQGDKLD 630
F CP+L GKPKLFF+QAC+G + D
Sbjct: 156 FNDSNCPSLQGKPKLFFVQACRGREDD 182
>UniRef50_A2I5C3 Cluster: Putative caspase 3; n=1; Mytilus
galloprovincialis|Rep: Putative caspase 3 - Mytilus
galloprovincialis (Mediterranean mussel)
Length = 56
Score = 45.2 bits (102), Expect = 0.002
Identities = 20/42 (47%), Positives = 25/42 (59%)
Frame = +1
Query: 514 DTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGI 639
DT K + YF A+ C L KPK+F IQAC+G L GG+
Sbjct: 14 DTSIKMKSFLSYFNAENCKELQLKPKIFIIQACRGTGLGGGV 55
>UniRef50_UPI0000661247 Cluster: Homolog of Brachydanio rerio
"Caspase.; n=4; Takifugu rubripes|Rep: Homolog of
Brachydanio rerio "Caspase. - Takifugu rubripes
Length = 358
Score = 44.8 bits (101), Expect = 0.003
Identities = 23/82 (28%), Positives = 42/82 (51%), Gaps = 1/82 (1%)
Frame = +2
Query: 263 MAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQISEM 442
+A++ + F H +R G D +++ +L+GLG+ V NL I + S+
Sbjct: 115 VALVITNITF-FHQCLNRKGAEKDEENMETLLKGLGYEVVKYRNLTGRAIEDAVIDFSKR 173
Query: 443 DH-TDNDCLLVAVLSHGELGML 505
D D ++V ++SHG LG++
Sbjct: 174 PKLKDTDSVVVVIMSHGRLGVV 195
Score = 38.3 bits (85), Expect = 0.24
Identities = 27/101 (26%), Positives = 46/101 (45%), Gaps = 10/101 (9%)
Frame = +1
Query: 511 KDTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTE-------TDGX 669
+D + D ++ + + CP L KPK+ IQAC+GD+ G I ++ +D
Sbjct: 206 EDDLFSLDKIYRHLGPEHCPALLNKPKIIIIQACRGDER-GEIIFNDQHPPENPPVSDDA 264
Query: 670 XXXXYRIPIH---ADFLIVFSTVPGYYSWRNTTRGSWVYAI 783
I I DF+ + S P S+R +GS++ +
Sbjct: 265 NIQEDAIRIEHKEKDFIWLLSCTPDTVSYRALAKGSFLVQV 305
>UniRef50_Q4SNC6 Cluster: Chromosome 8 SCAF14543, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 8
SCAF14543, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 397
Score = 44.8 bits (101), Expect = 0.003
Identities = 18/35 (51%), Positives = 24/35 (68%), Gaps = 2/35 (5%)
Frame = +1
Query: 541 WYYFTADK--CPTLAGKPKLFFIQACQGDKLDGGI 639
W + D CP L KPK+FFIQAC+GD++D G+
Sbjct: 265 WVFTAFDNAHCPLLQNKPKMFFIQACRGDEMDCGV 299
>UniRef50_Q9I9L7 Cluster: Caspase; n=2; Danio rerio|Rep: Caspase -
Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 383
Score = 44.0 bits (99), Expect = 0.005
Identities = 25/82 (30%), Positives = 41/82 (50%), Gaps = 2/82 (2%)
Frame = +1
Query: 532 DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIH--AD 705
DN++ ++ CP L KPK+ IQAC+G + G + S+ E D +H D
Sbjct: 244 DNVYRRLNSENCPALRDKPKVILIQACRGGE-HGRVWASDGEPDEPIEIEDDDFVHKEKD 302
Query: 706 FLIVFSTVPGYYSWRNTTRGSW 771
F+ + S P S+R+ G++
Sbjct: 303 FISLMSCTPDTKSYRHVQNGTF 324
>UniRef50_Q5BLH4 Cluster: Caspase c; n=4; Danio rerio|Rep: Caspase c
- Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 400
Score = 44.0 bits (99), Expect = 0.005
Identities = 23/77 (29%), Positives = 43/77 (55%), Gaps = 1/77 (1%)
Frame = +2
Query: 263 MAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQISEM 442
+A++ N+ FE L R G D S+ +L+GLG++V L +L A+ + ++ ++
Sbjct: 230 LALLINNVEFEY--LNDRKGAERDELSMEMLLKGLGYTVVTLRDLTAQGMLVAMRDFAQR 287
Query: 443 -DHTDNDCLLVAVLSHG 490
+H +D V ++SHG
Sbjct: 288 EEHAHSDSCFVVLMSHG 304
>UniRef50_Q4S1R8 Cluster: Chromosome undetermined SCAF14764, whole
genome shotgun sequence; n=2; Tetraodontidae|Rep:
Chromosome undetermined SCAF14764, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 279
Score = 43.2 bits (97), Expect = 0.008
Identities = 23/78 (29%), Positives = 46/78 (58%), Gaps = 5/78 (6%)
Frame = +1
Query: 535 NLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITL---SNTETDGXXXXXYR--IPIH 699
+++ YF +KC + K K+F IQAC+GD LD G+ + ++ + D ++ + +
Sbjct: 107 HIFAYFD-NKC--MEKKTKVFLIQACRGDALDDGVEVDAAADADADASAACVFQQCLSVP 163
Query: 700 ADFLIVFSTVPGYYSWRN 753
D +++++T PGY ++ N
Sbjct: 164 LDTVVMYATAPGYAAFMN 181
Score = 42.7 bits (96), Expect = 0.011
Identities = 27/86 (31%), Positives = 40/86 (46%)
Frame = +2
Query: 251 QYRGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQ 430
Q R I+ E + L+ R G + D+ L K L +GF V + +L + +I +Q
Sbjct: 13 QGRRAVIVSVGEFYPQVGLQRRPGASRDAKRLHKTLMKMGFKVDIHQDLSSGEIYELFEQ 72
Query: 431 ISEMDHTDNDCLLVAVLSHGELGMLY 508
E DC L + SHGE G +Y
Sbjct: 73 --ESRRPVEDCFLAVLSSHGEEGCVY 96
>UniRef50_UPI0000F2CF2E Cluster: PREDICTED: similar to caspase 12;
n=1; Monodelphis domestica|Rep: PREDICTED: similar to
caspase 12 - Monodelphis domestica
Length = 405
Score = 42.7 bits (96), Expect = 0.011
Identities = 30/104 (28%), Positives = 43/104 (41%), Gaps = 12/104 (11%)
Frame = +1
Query: 493 IRYVVSKDTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTET---- 660
I + K D ++ F CP+L GKPK+ IQAC+G+KL + E+
Sbjct: 246 IEHTKQKPDLLATDVIFQIFNDSNCPSLKGKPKVIIIQACRGEKLGITYVMDTPESSAGT 305
Query: 661 --------DGXXXXXYRIPIHADFLIVFSTVPGYYSWRNTTRGS 768
G ++ + DF+ ST P SWR GS
Sbjct: 306 PDQPMEDHSGNNPLEQKL-LEKDFISFCSTTPHNVSWRVDILGS 348
>UniRef50_Q07BT4 Cluster: Caspase-1; n=2; Percomorpha|Rep: Caspase-1
- Dicentrarchus labrax (European sea bass)
Length = 394
Score = 41.1 bits (92), Expect = 0.034
Identities = 16/54 (29%), Positives = 31/54 (57%)
Frame = +1
Query: 493 IRYVVSKDTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNT 654
+ Y + +N++ + ++KCP L KPK+ IQAC+G+ G + +S++
Sbjct: 227 VNYAEDNPDEFPINNIYEHLGSEKCPALLNKPKIIIIQACRGN-AGGAVLVSDS 279
>UniRef50_Q178B7 Cluster: Caspase-3; n=2; Aedes aegypti|Rep:
Caspase-3 - Aedes aegypti (Yellowfever mosquito)
Length = 391
Score = 40.7 bits (91), Expect = 0.045
Identities = 27/66 (40%), Positives = 33/66 (50%)
Frame = +1
Query: 571 TLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFLIVFSTVPGYYSWR 750
TL GKPKLFF+QAC+GD + E D + D L FST G S+R
Sbjct: 283 TLKGKPKLFFVQACKGDAV--------MEADATRTATNKF----DILKCFSTYEGTLSFR 330
Query: 751 NTTRGS 768
TT G+
Sbjct: 331 YTTEGT 336
>UniRef50_UPI0000F2CF2D Cluster: PREDICTED: similar to
evolutionarily related interleukin-1beta converting
enzyme; n=1; Monodelphis domestica|Rep: PREDICTED:
similar to evolutionarily related interleukin-1beta
converting enzyme - Monodelphis domestica
Length = 372
Score = 40.3 bits (90), Expect = 0.059
Identities = 25/97 (25%), Positives = 40/97 (41%), Gaps = 9/97 (9%)
Frame = +1
Query: 532 DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDG---------XXXXXY 684
D ++ CP L KPK+ IQAC+G K + + E +
Sbjct: 228 DTIFNILNTKNCPKLKDKPKVIIIQACRGVKSGKVLMRDSPEISEDSEINPELLEEDAIF 287
Query: 685 RIPIHADFLIVFSTVPGYYSWRNTTRGSWVYAISFVE 795
+ DF+ FS+ P SWR+ GS ++ I ++
Sbjct: 288 ETHVEKDFISFFSSTPNNVSWRDHENGS-IFIIKVID 323
Score = 39.1 bits (87), Expect = 0.14
Identities = 20/77 (25%), Positives = 39/77 (50%), Gaps = 1/77 (1%)
Frame = +2
Query: 287 HFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQI-SEMDHTDNDC 463
+ E RTG VD + +L+ LG++V V +L + ++ +++ + +H +D
Sbjct: 139 NIEFTYYSERTGAEVDIKGMEGLLKDLGYTVDVQRDLTSSEMASELRKFAARQEHESSDS 198
Query: 464 LLVAVLSHGELGMLYPK 514
V ++SHG L + K
Sbjct: 199 TFVVLMSHGILDAICGK 215
>UniRef50_A6NFM5 Cluster: Uncharacterized protein ENSP00000371619;
n=11; Eutheria|Rep: Uncharacterized protein
ENSP00000371619 - Homo sapiens (Human)
Length = 408
Score = 40.3 bits (90), Expect = 0.059
Identities = 23/70 (32%), Positives = 34/70 (48%), Gaps = 1/70 (1%)
Frame = +1
Query: 562 KCPTLAGKPKLFFIQACQGDKLDGGITLSNTETD-GXXXXXYRIPIHADFLIVFSTVPGY 738
+C L G+PK+F +QAC+G D G+ + +P HAD L +++ G
Sbjct: 254 RCQVLQGRPKIFLLQACRGGNRDAGVGPTALPWYWSWLRAPPSVPSHADVLQIYAEAQG- 312
Query: 739 YSWRNTTRGS 768
S R T GS
Sbjct: 313 SSCRGTPPGS 322
>UniRef50_P51878 Cluster: Caspase-5 precursor (EC 3.4.22.58)
(CASP-5) (ICH-3 protease) (TY protease) (ICE(rel)-III)
[Contains: Caspase-5 subunit p20; Caspase-5 subunit
p10]; n=25; Eutheria|Rep: Caspase-5 precursor (EC
3.4.22.58) (CASP-5) (ICH-3 protease) (TY protease)
(ICE(rel)-III) [Contains: Caspase-5 subunit p20;
Caspase-5 subunit p10] - Homo sapiens (Human)
Length = 418
Score = 40.3 bits (90), Expect = 0.059
Identities = 27/89 (30%), Positives = 41/89 (46%), Gaps = 10/89 (11%)
Frame = +1
Query: 532 DNLWYYFTADKCPTLAGKPKLFFIQACQGDK------LDGGITL----SNTETDGXXXXX 681
D ++ F C +L KPK+ +QAC+G+K D +L S + +
Sbjct: 273 DTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLAVISSQSSENLEADSV 332
Query: 682 YRIPIHADFLIVFSTVPGYYSWRNTTRGS 768
+I DF+ S+ P SWR+ TRGS
Sbjct: 333 CKIHEEKDFIAFCSSTPHNVSWRDRTRGS 361
>UniRef50_Q7ZXD2 Cluster: MGC53258 protein; n=3; Xenopus|Rep:
MGC53258 protein - Xenopus laevis (African clawed frog)
Length = 419
Score = 39.9 bits (89), Expect = 0.079
Identities = 14/25 (56%), Positives = 19/25 (76%)
Frame = +1
Query: 565 CPTLAGKPKLFFIQACQGDKLDGGI 639
CP L KPK+FF QAC+G++ D G+
Sbjct: 273 CPQLQNKPKMFFFQACRGEETDRGV 297
>UniRef50_O42284 Cluster: Caspase-1; n=3; Gallus gallus|Rep:
Caspase-1 - Gallus gallus (Chicken)
Length = 283
Score = 39.9 bits (89), Expect = 0.079
Identities = 28/103 (27%), Positives = 48/103 (46%), Gaps = 14/103 (13%)
Frame = +1
Query: 532 DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSN--------TETDGXXXXXYR 687
+ ++ F C L GKPK+ IQ C+GD + G + + + + +DG +
Sbjct: 137 NTIYENFNNKHCRALMGKPKVVIIQCCRGDNI-GSVQIRDSIDPEMPTSTSDGWRCVELQ 195
Query: 688 ------IPIHADFLIVFSTVPGYYSWRNTTRGSWVYAISFVEE 798
+ +DF ++S+ P SWR+ T GS V+ VE+
Sbjct: 196 GSKTREAHLESDFATLYSSTPDTVSWRSPTEGS-VFIQRLVEQ 237
>UniRef50_UPI000155BC01 Cluster: PREDICTED: similar to cellular
FLICE-like inhibitory protein long form; n=1;
Ornithorhynchus anatinus|Rep: PREDICTED: similar to
cellular FLICE-like inhibitory protein long form -
Ornithorhynchus anatinus
Length = 508
Score = 39.1 bits (87), Expect = 0.14
Identities = 15/21 (71%), Positives = 17/21 (80%)
Frame = +1
Query: 547 YFTADKCPTLAGKPKLFFIQA 609
+FT D CP L GKPKLFFIQ+
Sbjct: 369 FFTGDACPALLGKPKLFFIQS 389
>UniRef50_UPI0000E47F37 Cluster: PREDICTED: similar to caspase-3,
partial; n=3; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to caspase-3, partial -
Strongylocentrotus purpuratus
Length = 608
Score = 38.7 bits (86), Expect = 0.18
Identities = 13/26 (50%), Positives = 19/26 (73%)
Frame = +1
Query: 550 FTADKCPTLAGKPKLFFIQACQGDKL 627
F+ + CP L GKPK+ QAC+G+K+
Sbjct: 105 FSGNNCPALIGKPKIMIFQACRGEKI 130
>UniRef50_UPI0000587146 Cluster: PREDICTED: similar to caspase Xa;
n=1; Strongylocentrotus purpuratus|Rep: PREDICTED:
similar to caspase Xa - Strongylocentrotus purpuratus
Length = 221
Score = 37.9 bits (84), Expect = 0.32
Identities = 24/77 (31%), Positives = 37/77 (48%)
Frame = +1
Query: 571 TLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFLIVFSTVPGYYSWR 750
++ GKPK+ F Q C+G+ ETD I +D L+V +T G ++R
Sbjct: 91 SMIGKPKMIFFQCCRGEGTGKMEETDQVETD------EAIAAKSDVLMVHATTYGNKAYR 144
Query: 751 NTTRGSWVYAISFVEEL 801
+ +GSW + EEL
Sbjct: 145 DRGKGSW-FIQKLCEEL 160
>UniRef50_Q7QGN0 Cluster: ENSANGP00000018113; n=4; Anopheles gambiae
str. PEST|Rep: ENSANGP00000018113 - Anopheles gambiae
str. PEST
Length = 214
Score = 37.1 bits (82), Expect = 0.55
Identities = 19/75 (25%), Positives = 39/75 (52%), Gaps = 1/75 (1%)
Frame = +2
Query: 269 IIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFS-VTVLHNLRAEDINRYIQQISEMD 445
++F+H+ F+ + +R G+ D + + + + + N ++ R + +IS D
Sbjct: 5 LVFHHDQFK-NPKNNREGSANDMKQIKEFCQHYRCDRLDINENKTKAEVTRKMGEISRKD 63
Query: 446 HTDNDCLLVAVLSHG 490
T N CL+V ++SHG
Sbjct: 64 FTKNSCLIVFIMSHG 78
Score = 34.3 bits (75), Expect = 3.9
Identities = 28/92 (30%), Positives = 46/92 (50%), Gaps = 2/92 (2%)
Frame = +1
Query: 502 VVSKDTHYKP--DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXX 675
+++KD + D++ Y T+++ TL KPKLF +QAC+GD + D
Sbjct: 84 IMAKDGQFYSFQDDVVEYCTSNR--TLNDKPKLFVLQACRGD--------ATMVADATFS 133
Query: 676 XXYRIPIHADFLIVFSTVPGYYSWRNTTRGSW 771
Y+ D +I S+ G S+R+T GS+
Sbjct: 134 MSYK----GDIIIFQSSYQGAVSFRDTESGSF 161
>UniRef50_UPI0000DB7195 Cluster: PREDICTED: similar to caspase 10
isoform a preproprotein; n=1; Apis mellifera|Rep:
PREDICTED: similar to caspase 10 isoform a preproprotein
- Apis mellifera
Length = 247
Score = 36.7 bits (81), Expect = 0.73
Identities = 23/63 (36%), Positives = 33/63 (52%), Gaps = 2/63 (3%)
Frame = +1
Query: 589 KLFFIQACQGDKLDGGITLSNTETDGXXXXXY--RIPIHADFLIVFSTVPGYYSWRNTTR 762
K+ IQACQG K+ G + + TDG I + +F I ST+ G+ S R+ +
Sbjct: 121 KIVIIQACQG-KIIGQVE-DSLVTDGFINCNISKNILSYRNFCIFMSTIQGFVSMRHKEK 178
Query: 763 GSW 771
GSW
Sbjct: 179 GSW 181
>UniRef50_UPI0000D57084 Cluster: PREDICTED: similar to CG8091-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG8091-PA - Tribolium castaneum
Length = 395
Score = 36.7 bits (81), Expect = 0.73
Identities = 19/79 (24%), Positives = 34/79 (43%), Gaps = 5/79 (6%)
Frame = +1
Query: 550 FTADKCPTLAGKPKLFFIQACQGDKLDGGITLS-NTETDGXXXXXYRI----PIHADFLI 714
F C KPK+ C+GD +D + + T++D + ++D +I
Sbjct: 243 FNNQSCSLFRNKPKILIFNICRGDLVDNLVHFAQQTQSDSACTKNPEVGDDERYYSDLMI 302
Query: 715 VFSTVPGYYSWRNTTRGSW 771
+V G+ + R+ RG W
Sbjct: 303 CHPSVEGFQAHRDVVRGCW 321
>UniRef50_UPI000065DDFC Cluster: CASP8 and FADD-like apoptosis
regulator precursor (Cellular FLICE-like inhibitory
protein) (c-FLIP) (Caspase-eight-related protein)
(Casper) (Caspase-like apoptosis regulatory protein)
(CLARP) (MACH-related inducer of toxicity) (MRIT)
(Caspase homolog) (C; n=1; Takifugu rubripes|Rep: CASP8
and FADD-like apoptosis regulator precursor (Cellular
FLICE-like inhibitory protein) (c-FLIP)
(Caspase-eight-related protein) (Casper) (Caspase-like
apoptosis regulatory protein) (CLARP) (MACH-related
inducer of toxicity) (MRIT) (Caspase homolog) (C -
Takifugu rubripes
Length = 472
Score = 36.7 bits (81), Expect = 0.73
Identities = 16/25 (64%), Positives = 18/25 (72%)
Frame = +1
Query: 532 DNLWYYFTADKCPTLAGKPKLFFIQ 606
D++ FTA CP LAGKPKL FIQ
Sbjct: 332 DSVSQQFTAKGCPALAGKPKLLFIQ 356
>UniRef50_Q498I3 Cluster: LOC780745 protein; n=6; Xenopus|Rep:
LOC780745 protein - Xenopus laevis (African clawed frog)
Length = 512
Score = 36.7 bits (81), Expect = 0.73
Identities = 14/25 (56%), Positives = 17/25 (68%)
Frame = +1
Query: 532 DNLWYYFTADKCPTLAGKPKLFFIQ 606
D + + FT CP L GKPKLFF+Q
Sbjct: 377 DRIKHIFTGKSCPDLLGKPKLFFVQ 401
>UniRef50_Q5CX96 Cluster: Putative uncharacterized protein; n=4;
Cryptosporidium|Rep: Putative uncharacterized protein -
Cryptosporidium parvum Iowa II
Length = 2333
Score = 36.7 bits (81), Expect = 0.73
Identities = 23/77 (29%), Positives = 42/77 (54%), Gaps = 7/77 (9%)
Frame = +2
Query: 407 DINRYIQQISEMDHTDNDC-LLVAVLS------HGELGMLYPKTLIINQIICGITSLLIN 565
DIN++I++ D ++N C L+++L + ++ LY +I+N II IT L+I
Sbjct: 848 DINQWIKKFERFDLSENFCEFLISLLKNLVLIINKDIQYLYFNNIIVNSIISNITKLIIK 907
Query: 566 VQL*LENQSCSLFKLAK 616
+ E ++ KL+K
Sbjct: 908 ITEIYELNLINISKLSK 924
>UniRef50_O15519-8 Cluster: Isoform 8 of O15519 ; n=3;
Homo/Pan/Gorilla group|Rep: Isoform 8 of O15519 - Homo
sapiens (Human)
Length = 445
Score = 35.9 bits (79), Expect = 1.3
Identities = 14/19 (73%), Positives = 15/19 (78%)
Frame = +1
Query: 550 FTADKCPTLAGKPKLFFIQ 606
F D CP LAGKPK+FFIQ
Sbjct: 305 FMGDSCPYLAGKPKMFFIQ 323
>UniRef50_Q896Y6 Cluster: Putative uncharacterized protein; n=1;
Clostridium tetani|Rep: Putative uncharacterized protein
- Clostridium tetani
Length = 231
Score = 35.9 bits (79), Expect = 1.3
Identities = 21/60 (35%), Positives = 31/60 (51%), Gaps = 1/60 (1%)
Frame = +2
Query: 257 RGMAIIFNHE-HFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQI 433
+G+++ F H E+ L R G N SD + LR LGF+ L +L D NR+ +I
Sbjct: 33 QGVSVDFEQSLHQELDRLGYREGMNPSSDEMLVFLRNLGFTDKELIDLYQSDANRFNSKI 92
>UniRef50_Q7KHK9 Cluster: DREAM; n=2; Sophophora|Rep: DREAM -
Drosophila melanogaster (Fruit fly)
Length = 527
Score = 35.9 bits (79), Expect = 1.3
Identities = 20/55 (36%), Positives = 28/55 (50%)
Frame = +1
Query: 502 VVSKDTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDG 666
+ +KD Y D+ F + TL KPKL F+QAC+GD GG + +G
Sbjct: 394 IAAKDDDYSLDDD-VVFPILRNRTLKDKPKLIFVQACKGDCQLGGFMTDAAQPNG 447
>UniRef50_Q5JRU9 Cluster: Caspase 9, apoptosis-related cysteine
peptidase; n=3; Homo sapiens|Rep: Caspase 9,
apoptosis-related cysteine peptidase - Homo sapiens
(Human)
Length = 266
Score = 35.9 bits (79), Expect = 1.3
Identities = 12/28 (42%), Positives = 18/28 (64%)
Frame = +1
Query: 688 IPIHADFLIVFSTVPGYYSWRNTTRGSW 771
+P +D + +ST PG+ SWR+ GSW
Sbjct: 185 LPTPSDIFVSYSTFPGFVSWRDPKSGSW 212
>UniRef50_O15519 Cluster: CASP8 and FADD-like apoptosis regulator
precursor (Cellular FLICE-like inhibitory protein)
(c-FLIP) (Caspase-eight-related protein) (Casper)
(Caspase-like apoptosis regulatory protein) (CLARP)
(MACH-related inducer of toxicity) (MRIT) (Caspase
homolog) (CASH) (Inhibitor of FLICE) (I-FLICE)
(FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin)
[Contains: CASP8 and FADD-like apoptosis regulator
subunit p43; CASP8 and FADD-like apoptosis regulator
subunit p12]; n=46; Amniota|Rep: CASP8 and FADD-like
apoptosis regulator precursor (Cellular FLICE-like
inhibitory protein) (c-FLIP) (Caspase-eight-related
protein) (Casper) (Caspase-like apoptosis regulatory
protein) (CLARP) (MACH-related inducer of toxicity)
(MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE)
(I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1)
(Usurpin) [Contains: CASP8 and FADD-like apoptosis
regulator subunit p43; CASP8 and FADD-like apoptosis
regulator subunit p12] - Homo sapiens (Human)
Length = 480
Score = 35.9 bits (79), Expect = 1.3
Identities = 14/19 (73%), Positives = 15/19 (78%)
Frame = +1
Query: 550 FTADKCPTLAGKPKLFFIQ 606
F D CP LAGKPK+FFIQ
Sbjct: 340 FMGDSCPYLAGKPKMFFIQ 358
>UniRef50_Q8IRY7 Cluster: Caspase-8 precursor (EC 3.4.22.61)
(Death-related Ced-3/NEDD2-like protein) [Contains:
Caspase-8 subunit p15; Caspase-8 subunit p10]; n=7;
Sophophora|Rep: Caspase-8 precursor (EC 3.4.22.61)
(Death-related Ced-3/NEDD2-like protein) [Contains:
Caspase-8 subunit p15; Caspase-8 subunit p10] -
Drosophila melanogaster (Fruit fly)
Length = 516
Score = 35.9 bits (79), Expect = 1.3
Identities = 27/67 (40%), Positives = 30/67 (44%)
Frame = +1
Query: 571 TLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFLIVFSTVPGYYSWR 750
TL KPKL IQACQ +KL E H D L STV GY + R
Sbjct: 395 TLYYKPKLLIIQACQ-EKLVH--KKKPNELFRIDVTTVSPDQHIDMLRAMSTVNGYAALR 451
Query: 751 NTTRGSW 771
+T GSW
Sbjct: 452 HTQTGSW 458
>UniRef50_Q03703 Cluster: Uncharacterized protein YML037C; n=2;
Saccharomyces cerevisiae|Rep: Uncharacterized protein
YML037C - Saccharomyces cerevisiae (Baker's yeast)
Length = 340
Score = 35.5 bits (78), Expect = 1.7
Identities = 16/53 (30%), Positives = 32/53 (60%), Gaps = 1/53 (1%)
Frame = +3
Query: 66 LLRFVIFKMADEEKKNNGSGTEQRKNGNEDEGDAWGSHGSSQG-RRYAKMPVE 221
L +FV+ ++ E+KK++G T++ K+ + WG GS G ++ ++ P+E
Sbjct: 187 LQKFVVKELPKEKKKSDGDKTKKNKSKRKSFFGFWGHSGSKSGSKKKSEKPIE 239
>UniRef50_Q9UTJ8 Cluster: DNA repair protein rad50; n=1;
Schizosaccharomyces pombe|Rep: DNA repair protein rad50 -
Schizosaccharomyces pombe (Fission yeast)
Length = 1290
Score = 35.1 bits (77), Expect = 2.2
Identities = 20/77 (25%), Positives = 40/77 (51%), Gaps = 2/77 (2%)
Frame = +2
Query: 284 EHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQISEMDH--TDN 457
E F +K++T T ++ L K + L ++ LH+++ +INR + ++ + + TD
Sbjct: 1088 ERFRRQLIKTKT-TGKANEDLGKYAKALDVAIMQLHSMKMNEINRIVDELWKQTYCGTDI 1146
Query: 458 DCLLVAVLSHGELGMLY 508
D +L+ S G+ Y
Sbjct: 1147 DTILIRSDSEGKGNRTY 1163
>UniRef50_Q5E9C1 Cluster: Caspase-4 precursor (EC 3.4.22.57)
(CASP-4) [Contains: Caspase-4 subunit 1; Caspase-4
subunit 2]; n=9; Eutheria|Rep: Caspase-4 precursor (EC
3.4.22.57) (CASP-4) [Contains: Caspase-4 subunit 1;
Caspase-4 subunit 2] - Bos taurus (Bovine)
Length = 377
Score = 35.1 bits (77), Expect = 2.2
Identities = 24/89 (26%), Positives = 38/89 (42%), Gaps = 10/89 (11%)
Frame = +1
Query: 532 DNLWYYFTADKCPTLAGKPKLFFIQACQGDK------LDGGITL----SNTETDGXXXXX 681
D ++ F C +L KPK+ +QAC+G D L S + +
Sbjct: 232 DTIFRTFNNRNCLSLKDKPKVIIVQACRGANRGELWVSDSPPALADSFSQSSENLEEDAV 291
Query: 682 YRIPIHADFLIVFSTVPGYYSWRNTTRGS 768
Y+ + DF+ S+ P SWR+ +GS
Sbjct: 292 YKTHVEKDFIAFCSSTPHNVSWRDIKKGS 320
>UniRef50_Q74BT1 Cluster: Fibronectin type III domain protein; n=2;
Geobacter|Rep: Fibronectin type III domain protein -
Geobacter sulfurreducens
Length = 1047
Score = 33.9 bits (74), Expect = 5.2
Identities = 23/104 (22%), Positives = 42/104 (40%), Gaps = 1/104 (0%)
Frame = +1
Query: 478 VESWRI-RYVVSKDTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNT 654
V+S+R+ + DT+ +P + Y P+ P + G + G +T+S T
Sbjct: 662 VDSYRLFASSEASDTNLRPKLVVTY----NLPSDTAAPTVAVSAPANGATVSGTVTVSAT 717
Query: 655 ETDGXXXXXYRIPIHADFLIVFSTVPGYYSWRNTTRGSWVYAIS 786
+D ++ +T P YSW TT + Y ++
Sbjct: 718 ASDNVGVTKVEFMVNGTVASTVTTAPYSYSWNTTTSANGTYTLT 761
>UniRef50_A4QWM4 Cluster: Putative uncharacterized protein; n=1;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 702
Score = 33.9 bits (74), Expect = 5.2
Identities = 15/38 (39%), Positives = 20/38 (52%)
Frame = +3
Query: 87 KMADEEKKNNGSGTEQRKNGNEDEGDAWGSHGSSQGRR 200
K+ADEE G G R++G D+ A +HGS R
Sbjct: 421 KLADEEHHEGGGGQRGRRHGGHDDKAAAAAHGSGSRSR 458
>UniRef50_Q4N957 Cluster: Putative uncharacterized protein; n=1;
Theileria parva|Rep: Putative uncharacterized protein -
Theileria parva
Length = 2383
Score = 33.1 bits (72), Expect = 9.0
Identities = 14/50 (28%), Positives = 27/50 (54%)
Frame = +3
Query: 48 VQLFARLLRFVIFKMADEEKKNNGSGTEQRKNGNEDEGDAWGSHGSSQGR 197
V L+ R +F++ +D+ K+ + G + K G E+E + G G +G+
Sbjct: 986 VYLYLRSGQFIVVSPSDQRKEISLRGLTEGKEGEEEEEEEGGEEGKEEGK 1035
>UniRef50_O08736 Cluster: Caspase-12 precursor; n=12; Eutheria|Rep:
Caspase-12 precursor - Mus musculus (Mouse)
Length = 419
Score = 33.1 bits (72), Expect = 9.0
Identities = 22/91 (24%), Positives = 39/91 (42%), Gaps = 12/91 (13%)
Frame = +1
Query: 532 DNLWYYFTADKCPTLAGKPKLFFIQACQGD-------KLDGGITLSNTETDGXXXXXY-- 684
D ++ F C +L KPK+ +QAC+G + GI ++T+ + +
Sbjct: 272 DTIFKIFNNSNCRSLRNKPKILIMQACRGRYNGTIWVSTNKGIATADTDEERVLSCKWNN 331
Query: 685 ---RIPIHADFLIVFSTVPGYYSWRNTTRGS 768
+ + DF+ S+ P SW+ GS
Sbjct: 332 SITKAHVETDFIAFKSSTPHNISWKVGKTGS 362
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 841,721,977
Number of Sequences: 1657284
Number of extensions: 16939806
Number of successful extensions: 43884
Number of sequences better than 10.0: 136
Number of HSP's better than 10.0 without gapping: 40883
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 43684
length of database: 575,637,011
effective HSP length: 100
effective length of database: 409,908,611
effective search space used: 74193458591
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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