Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= ceN-4499
(709 letters)
Database: fruitfly
53,049 sequences; 24,988,368 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
AY070617-1|AAL48088.1| 233|Drosophila melanogaster RE71995p pro... 81 1e-15
AE014297-421|AAF51900.1| 233|Drosophila melanogaster CG15592-PA... 81 1e-15
AE014297-420|AAF51901.1| 274|Drosophila melanogaster CG15591-PA... 50 3e-06
BT009951-1|AAQ22420.1| 295|Drosophila melanogaster RH51767p pro... 46 5e-05
AE014297-425|AAF51897.2| 295|Drosophila melanogaster CG1154-PA ... 46 5e-05
AY058538-1|AAL13767.1| 268|Drosophila melanogaster LD24139p pro... 40 0.003
AF231039-1|AAF34808.1| 268|Drosophila melanogaster SP558 protei... 40 0.003
AE014297-430|AAF51893.1| 268|Drosophila melanogaster CG1155-PA ... 40 0.003
AE014297-432|AAN13237.1| 278|Drosophila melanogaster CG31561-PA... 36 0.071
BT016007-1|AAV36892.1| 288|Drosophila melanogaster RE26656p pro... 33 0.50
AE014297-419|AAF51902.1| 288|Drosophila melanogaster CG1153-PA ... 33 0.50
AE014297-424|AAF51898.1| 302|Drosophila melanogaster CG15596-PA... 32 0.66
AE014134-2062|AAF53094.1| 282|Drosophila melanogaster CG14925-P... 32 0.66
BT023949-1|ABB36453.1| 1312|Drosophila melanogaster IP03879p pro... 31 1.2
AE014298-2334|AAF48566.2| 1311|Drosophila melanogaster CG32577-P... 31 1.2
BT029275-1|ABK30912.1| 640|Drosophila melanogaster IP09721p pro... 31 2.0
BT022190-1|AAY51584.1| 640|Drosophila melanogaster IP01192p pro... 31 2.0
AE014298-752|AAF46043.2| 640|Drosophila melanogaster CG33980-PA... 31 2.0
BT003530-1|AAO39534.1| 674|Drosophila melanogaster RE12147p pro... 29 6.2
AF132170-1|AAD34758.1| 286|Drosophila melanogaster unknown prot... 29 6.2
AE014298-1633|AAF48053.2| 784|Drosophila melanogaster CG32666-P... 29 6.2
AE014298-1632|AAS65317.1| 784|Drosophila melanogaster CG32666-P... 29 6.2
AE014297-418|AAF51903.2| 312|Drosophila melanogaster CG1151-PA ... 29 6.2
BT003287-1|AAO25045.1| 520|Drosophila melanogaster GM08204p pro... 29 8.2
AY069187-1|AAL39332.1| 465|Drosophila melanogaster GH23955p pro... 29 8.2
AE014297-905|AAN13414.1| 465|Drosophila melanogaster CG8866-PB,... 29 8.2
AE014297-904|AAF54358.1| 520|Drosophila melanogaster CG8866-PA,... 29 8.2
>AY070617-1|AAL48088.1| 233|Drosophila melanogaster RE71995p
protein.
Length = 233
Score = 81.4 bits (192), Expect = 1e-15
Identities = 52/195 (26%), Positives = 90/195 (46%), Gaps = 3/195 (1%)
Frame = +2
Query: 116 EDVFRSVMGVLKTCSDDNVALCLKEKALRYVENVSNSRELNLIDGVSLIGQGSPRSARSF 295
+ + S + ++K C + ++ LC+KE+AL Y + + + ++ L +G++L+ RS
Sbjct: 22 DSLLTSALKMVKDCGERSMVLCMKERALHYFD--AENGDVRLTEGIALVKTDEIPVGRSL 79
Query: 296 EP--LPDEPRARENQVDLRLLDGVADFLENFVIQIRLPKGAIESAKRSLEEGRG-XXXXX 466
LP+E ARE +VD L++ VA F +Q ++PK +I+ +R+LEE RG
Sbjct: 80 NEMQLPEEVEAREAEVDSLLVERVARFFGTHTLQFKVPKDSIQDMQRALEESRGKKKEKK 139
Query: 467 XXXXXXXXXXXXXXXSLIPVFLGIIAFXXXXXXXXXXXXXXXXXXXXXXXXXXXNDHHES 646
+L+P+ +G +A E+
Sbjct: 140 KYLMPLLMLFKLKMAALLPLAIGFLAL--ISFKALVIGKIALLLSGIIGLKKLLESKKEN 197
Query: 647 YEVVAHPHHEEHFSH 691
YEVVAHPH+E S+
Sbjct: 198 YEVVAHPHYEHEHSY 212
>AE014297-421|AAF51900.1| 233|Drosophila melanogaster CG15592-PA
protein.
Length = 233
Score = 81.4 bits (192), Expect = 1e-15
Identities = 52/195 (26%), Positives = 90/195 (46%), Gaps = 3/195 (1%)
Frame = +2
Query: 116 EDVFRSVMGVLKTCSDDNVALCLKEKALRYVENVSNSRELNLIDGVSLIGQGSPRSARSF 295
+ + S + ++K C + ++ LC+KE+AL Y + + + ++ L +G++L+ RS
Sbjct: 22 DSLLTSALKMVKDCGERSMVLCMKERALHYFD--AENGDVRLTEGIALVKTDEIPVGRSL 79
Query: 296 EP--LPDEPRARENQVDLRLLDGVADFLENFVIQIRLPKGAIESAKRSLEEGRG-XXXXX 466
LP+E ARE +VD L++ VA F +Q ++PK +I+ +R+LEE RG
Sbjct: 80 NEMQLPEEVEAREAEVDSLLVERVARFFGTHTLQFKVPKDSIQDMQRALEESRGKKKEKK 139
Query: 467 XXXXXXXXXXXXXXXSLIPVFLGIIAFXXXXXXXXXXXXXXXXXXXXXXXXXXXNDHHES 646
+L+P+ +G +A E+
Sbjct: 140 KYLMPLLMLFKLKMAALLPLAIGFLAL--ISFKALVIGKIALLLSGIIGLKKLLESKKEN 197
Query: 647 YEVVAHPHHEEHFSH 691
YEVVAHPH+E S+
Sbjct: 198 YEVVAHPHYEHEHSY 212
>AE014297-420|AAF51901.1| 274|Drosophila melanogaster CG15591-PA
protein.
Length = 274
Score = 50.0 bits (114), Expect = 3e-06
Identities = 33/118 (27%), Positives = 61/118 (51%), Gaps = 12/118 (10%)
Frame = +2
Query: 134 VMGVLKTCSDDNVALCLKEKALRYVENVSNS-RELNLIDGVSLIGQG--------SPRSA 286
V + + CS DN+++CLK K L +E S + L+L++G+ + G +P S
Sbjct: 61 VYRIYQQCSGDNMSVCLKVKLLTGLEKAFRSAKSLSLMEGIQFVSSGGESEETKRAPISE 120
Query: 287 RSFEP-LPDEPRARENQVDLRLLDGVADFLENFVIQIRLPKGA--IESAKRSLEEGRG 451
+ E LP A+E ++ +L V +FL++ +Q++ A +E K+ ++G G
Sbjct: 121 KDIEAVLPRSVDAKEQVLNNMILKRVGNFLQDHTLQVKFDNEANSVEGRKKKEKKGNG 178
>BT009951-1|AAQ22420.1| 295|Drosophila melanogaster RH51767p
protein.
Length = 295
Score = 46.0 bits (104), Expect = 5e-05
Identities = 29/116 (25%), Positives = 58/116 (50%), Gaps = 8/116 (6%)
Frame = +2
Query: 128 RSVMGVLKTCSDDNVAL--CLKEKALRYVENVSNSRELNLIDGVSLIG-QGSPRSARSFE 298
R+++ V C+ CLK+KA+ +++ ++ +N+ +G+ L+ + +PR + E
Sbjct: 46 RTLLRVYDECTRAEAGFVPCLKKKAISFIDRLAPIDAINVAEGIKLVRLETAPRPPATSE 105
Query: 299 -----PLPDEPRARENQVDLRLLDGVADFLENFVIQIRLPKGAIESAKRSLEEGRG 451
LP R+ ++ L++ ++ F +Q+ PK + R LEEGRG
Sbjct: 106 NELESSLPRSGSDRDAKLTNMLIERLSYFFNGHSLQVSFPKLTSDEIGRGLEEGRG 161
>AE014297-425|AAF51897.2| 295|Drosophila melanogaster CG1154-PA
protein.
Length = 295
Score = 46.0 bits (104), Expect = 5e-05
Identities = 29/116 (25%), Positives = 58/116 (50%), Gaps = 8/116 (6%)
Frame = +2
Query: 128 RSVMGVLKTCSDDNVAL--CLKEKALRYVENVSNSRELNLIDGVSLIG-QGSPRSARSFE 298
R+++ V C+ CLK+KA+ +++ ++ +N+ +G+ L+ + +PR + E
Sbjct: 46 RTLLRVYDECTRAEAGFVPCLKKKAISFIDRLAPIDAINVAEGIKLVRLETAPRPPATSE 105
Query: 299 -----PLPDEPRARENQVDLRLLDGVADFLENFVIQIRLPKGAIESAKRSLEEGRG 451
LP R+ ++ L++ ++ F +Q+ PK + R LEEGRG
Sbjct: 106 NELESSLPRSGSDRDAKLTNMLIERLSYFFNGHSLQVSFPKLTSDEIGRGLEEGRG 161
>AY058538-1|AAL13767.1| 268|Drosophila melanogaster LD24139p
protein.
Length = 268
Score = 39.9 bits (89), Expect = 0.003
Identities = 28/105 (26%), Positives = 47/105 (44%), Gaps = 9/105 (8%)
Frame = +2
Query: 164 DNVALCLKEKALRYVENVSNSRELNLIDGVSLIGQ-GSP--RSARS------FEPLPDEP 316
D++A CL K + + + S + L GV+ SP R+ +S + LP
Sbjct: 48 DDMATCLAVKGITALNRAARSNNIELASGVTFQRDPASPVSRTGKSMSEQDVYAELPQNA 107
Query: 317 RARENQVDLRLLDGVADFLENFVIQIRLPKGAIESAKRSLEEGRG 451
R ++ + ADFL ++ +LP + R+L+EGRG
Sbjct: 108 DERTGRLVDLAVSSAADFLSTHNLEFKLPAETTQQVARALDEGRG 152
>AF231039-1|AAF34808.1| 268|Drosophila melanogaster SP558 protein
protein.
Length = 268
Score = 39.9 bits (89), Expect = 0.003
Identities = 28/105 (26%), Positives = 47/105 (44%), Gaps = 9/105 (8%)
Frame = +2
Query: 164 DNVALCLKEKALRYVENVSNSRELNLIDGVSLIGQ-GSP--RSARS------FEPLPDEP 316
D++A CL K + + + S + L GV+ SP R+ +S + LP
Sbjct: 48 DDMATCLAVKGITALNRAARSNNIELASGVTFQRDPASPVSRTGKSMSEQDVYAELPQNA 107
Query: 317 RARENQVDLRLLDGVADFLENFVIQIRLPKGAIESAKRSLEEGRG 451
R ++ + ADFL ++ +LP + R+L+EGRG
Sbjct: 108 DERTRRLVDLAVSSAADFLSTHNLEFKLPAETTQQVARALDEGRG 152
>AE014297-430|AAF51893.1| 268|Drosophila melanogaster CG1155-PA
protein.
Length = 268
Score = 39.9 bits (89), Expect = 0.003
Identities = 28/105 (26%), Positives = 47/105 (44%), Gaps = 9/105 (8%)
Frame = +2
Query: 164 DNVALCLKEKALRYVENVSNSRELNLIDGVSLIGQ-GSP--RSARS------FEPLPDEP 316
D++A CL K + + + S + L GV+ SP R+ +S + LP
Sbjct: 48 DDMATCLAVKGITALNRAARSNNIELASGVTFQRDPASPVSRTGKSMSEQDVYAELPQNA 107
Query: 317 RARENQVDLRLLDGVADFLENFVIQIRLPKGAIESAKRSLEEGRG 451
R ++ + ADFL ++ +LP + R+L+EGRG
Sbjct: 108 DERTGRLVDLAVSSAADFLSTHNLEFKLPAETTQQVARALDEGRG 152
>AE014297-432|AAN13237.1| 278|Drosophila melanogaster CG31561-PA
protein.
Length = 278
Score = 35.5 bits (78), Expect = 0.071
Identities = 23/91 (25%), Positives = 48/91 (52%)
Frame = +2
Query: 176 LCLKEKALRYVENVSNSRELNLIDGVSLIGQGSPRSARSFEPLPDEPRARENQVDLRLLD 355
+CLK + ++ +E ++ ELN++ G+S++ + ++ E + + R+ + RL
Sbjct: 62 MCLKIEFVKIMEKLAEQEELNVLPGISVVKDENATELKTSELMAEVARSYPSDPSTRLNG 121
Query: 356 GVADFLENFVIQIRLPKGAIESAKRSLEEGR 448
+ LEN +++ R + + K SL EGR
Sbjct: 122 YIVAKLEN-LLRTRFLRFRLLDDK-SLVEGR 150
>BT016007-1|AAV36892.1| 288|Drosophila melanogaster RE26656p
protein.
Length = 288
Score = 32.7 bits (71), Expect = 0.50
Identities = 14/22 (63%), Positives = 16/22 (72%)
Frame = +2
Query: 632 DHHESYEVVAHPHHEEHFSHST 697
+ H +YEVVAHPHH SHST
Sbjct: 222 EKHVTYEVVAHPHHSS--SHST 241
>AE014297-419|AAF51902.1| 288|Drosophila melanogaster CG1153-PA
protein.
Length = 288
Score = 32.7 bits (71), Expect = 0.50
Identities = 14/22 (63%), Positives = 16/22 (72%)
Frame = +2
Query: 632 DHHESYEVVAHPHHEEHFSHST 697
+ H +YEVVAHPHH SHST
Sbjct: 222 EKHVTYEVVAHPHHSS--SHST 241
>AE014297-424|AAF51898.1| 302|Drosophila melanogaster CG15596-PA
protein.
Length = 302
Score = 32.3 bits (70), Expect = 0.66
Identities = 27/111 (24%), Positives = 54/111 (48%), Gaps = 11/111 (9%)
Frame = +2
Query: 107 NSDEDVFRSVMGVLKTCS-DDNVALCLKEKALRYVENVSNSRELNLIDGVSLIGQGS--- 274
+++ + R+V + C+ ++V C K + +R + +L ++DGVSL+ + S
Sbjct: 31 STESGLLRTVRHIYGQCAYSEDVFWCCKIQGVRLLGRALKVPQLGIVDGVSLVRRESFTQ 90
Query: 275 -PRSARSFEPLPDEPRARE------NQVDLRLLDGVADFLENFVIQIRLPK 406
RS RS L + R+ +D LL+ +F+ + +Q+ LP+
Sbjct: 91 DTRSGRS-SLLESQLSNRDLEHLSGKSLDALLLERFLNFVHSHQLQVNLPR 140
>AE014134-2062|AAF53094.1| 282|Drosophila melanogaster CG14925-PA
protein.
Length = 282
Score = 32.3 bits (70), Expect = 0.66
Identities = 23/99 (23%), Positives = 41/99 (41%), Gaps = 2/99 (2%)
Frame = +2
Query: 134 VMGVLKTCSDDNVAL-CLKEKALRYVENVSNSRELNLIDGVSLIGQGSPRSARSFEPLPD 310
V V C D N + CLK+KAL + + + ++DG++L Q + L D
Sbjct: 54 VRRVYDDCQDKNDFIGCLKQKALHALSRALDQDSIKIVDGLALEKQNQSETESILGSLTD 113
Query: 311 EPR-ARENQVDLRLLDGVADFLENFVIQIRLPKGAIESA 424
+ + +D LL + ++I + G E +
Sbjct: 114 ARQFGNLSPIDRALLSKADKLMRTHTLKIDMDVGGGEDS 152
>BT023949-1|ABB36453.1| 1312|Drosophila melanogaster IP03879p
protein.
Length = 1312
Score = 31.5 bits (68), Expect = 1.2
Identities = 11/27 (40%), Positives = 14/27 (51%)
Frame = +2
Query: 629 NDHHESYEVVAHPHHEEHFSHSTGGGG 709
N HH Y+ H H+ +H H GGG
Sbjct: 86 NQHHHPYQHQHHHHYHQHHPHLPTGGG 112
>AE014298-2334|AAF48566.2| 1311|Drosophila melanogaster CG32577-PA
protein.
Length = 1311
Score = 31.5 bits (68), Expect = 1.2
Identities = 11/27 (40%), Positives = 14/27 (51%)
Frame = +2
Query: 629 NDHHESYEVVAHPHHEEHFSHSTGGGG 709
N HH Y+ H H+ +H H GGG
Sbjct: 86 NQHHHPYQHQHHHHYHQHHPHLPTGGG 112
>BT029275-1|ABK30912.1| 640|Drosophila melanogaster IP09721p
protein.
Length = 640
Score = 30.7 bits (66), Expect = 2.0
Identities = 10/24 (41%), Positives = 12/24 (50%)
Frame = +2
Query: 635 HHESYEVVAHPHHEEHFSHSTGGG 706
HH ++ HPHH H H GG
Sbjct: 138 HHHQHQHQHHPHHHPHHPHGAVGG 161
>BT022190-1|AAY51584.1| 640|Drosophila melanogaster IP01192p
protein.
Length = 640
Score = 30.7 bits (66), Expect = 2.0
Identities = 10/24 (41%), Positives = 12/24 (50%)
Frame = +2
Query: 635 HHESYEVVAHPHHEEHFSHSTGGG 706
HH ++ HPHH H H GG
Sbjct: 138 HHHQHQHQHHPHHHPHHPHGAVGG 161
>AE014298-752|AAF46043.2| 640|Drosophila melanogaster CG33980-PA
protein.
Length = 640
Score = 30.7 bits (66), Expect = 2.0
Identities = 10/24 (41%), Positives = 12/24 (50%)
Frame = +2
Query: 635 HHESYEVVAHPHHEEHFSHSTGGG 706
HH ++ HPHH H H GG
Sbjct: 138 HHHQHQHQHHPHHHPHHPHGAVGG 161
>BT003530-1|AAO39534.1| 674|Drosophila melanogaster RE12147p
protein.
Length = 674
Score = 29.1 bits (62), Expect = 6.2
Identities = 14/31 (45%), Positives = 16/31 (51%)
Frame = -3
Query: 173 RRCHRSKFSALPSLIGRRLRHYSLRPQRILL 81
R C R AL L R + H L+PQ ILL
Sbjct: 138 RHCMREVLKALKFLHDRSIAHLDLKPQNILL 168
>AF132170-1|AAD34758.1| 286|Drosophila melanogaster unknown
protein.
Length = 286
Score = 29.1 bits (62), Expect = 6.2
Identities = 13/53 (24%), Positives = 25/53 (47%)
Frame = +2
Query: 140 GVLKTCSDDNVALCLKEKALRYVENVSNSRELNLIDGVSLIGQGSPRSARSFE 298
G C + + CL+ R ++V ++ ++ L GVSL+ R +S +
Sbjct: 30 GAFAQCLESDSISCLQLTLFRKAKSVFDNPQIELFGGVSLVKSNEGRQGKSLD 82
>AE014298-1633|AAF48053.2| 784|Drosophila melanogaster CG32666-PB,
isoform B protein.
Length = 784
Score = 29.1 bits (62), Expect = 6.2
Identities = 14/31 (45%), Positives = 16/31 (51%)
Frame = -3
Query: 173 RRCHRSKFSALPSLIGRRLRHYSLRPQRILL 81
R C R AL L R + H L+PQ ILL
Sbjct: 138 RHCMREVLKALKFLHDRSIAHLDLKPQNILL 168
>AE014298-1632|AAS65317.1| 784|Drosophila melanogaster CG32666-PA,
isoform A protein.
Length = 784
Score = 29.1 bits (62), Expect = 6.2
Identities = 14/31 (45%), Positives = 16/31 (51%)
Frame = -3
Query: 173 RRCHRSKFSALPSLIGRRLRHYSLRPQRILL 81
R C R AL L R + H L+PQ ILL
Sbjct: 138 RHCMREVLKALKFLHDRSIAHLDLKPQNILL 168
>AE014297-418|AAF51903.2| 312|Drosophila melanogaster CG1151-PA
protein.
Length = 312
Score = 29.1 bits (62), Expect = 6.2
Identities = 13/53 (24%), Positives = 25/53 (47%)
Frame = +2
Query: 140 GVLKTCSDDNVALCLKEKALRYVENVSNSRELNLIDGVSLIGQGSPRSARSFE 298
G C + + CL+ R ++V ++ ++ L GVSL+ R +S +
Sbjct: 56 GAFAQCLESDSISCLQLTLFRKAKSVFDNPQIELFGGVSLVKSNEGRQGKSLD 108
>BT003287-1|AAO25045.1| 520|Drosophila melanogaster GM08204p
protein.
Length = 520
Score = 28.7 bits (61), Expect = 8.2
Identities = 16/49 (32%), Positives = 23/49 (46%)
Frame = -3
Query: 224 NSRHFPRIAKLFP*DTMRRCHRSKFSALPSLIGRRLRHYSLRPQRILLT 78
N F R K P T R R +A+ + + H+ L+PQ +LLT
Sbjct: 92 NLSAFIRTKKALPESTCRYFLRQLAAAVQYMRANDVSHFDLKPQNLLLT 140
>AY069187-1|AAL39332.1| 465|Drosophila melanogaster GH23955p
protein.
Length = 465
Score = 28.7 bits (61), Expect = 8.2
Identities = 16/49 (32%), Positives = 23/49 (46%)
Frame = -3
Query: 224 NSRHFPRIAKLFP*DTMRRCHRSKFSALPSLIGRRLRHYSLRPQRILLT 78
N F R K P T R R +A+ + + H+ L+PQ +LLT
Sbjct: 92 NLSAFIRTKKALPESTCRYFLRQLAAAVQYMRANDVSHFDLKPQNLLLT 140
>AE014297-905|AAN13414.1| 465|Drosophila melanogaster CG8866-PB,
isoform B protein.
Length = 465
Score = 28.7 bits (61), Expect = 8.2
Identities = 16/49 (32%), Positives = 23/49 (46%)
Frame = -3
Query: 224 NSRHFPRIAKLFP*DTMRRCHRSKFSALPSLIGRRLRHYSLRPQRILLT 78
N F R K P T R R +A+ + + H+ L+PQ +LLT
Sbjct: 92 NLSAFIRTKKALPESTCRYFLRQLAAAVQYMRANDVSHFDLKPQNLLLT 140
>AE014297-904|AAF54358.1| 520|Drosophila melanogaster CG8866-PA,
isoform A protein.
Length = 520
Score = 28.7 bits (61), Expect = 8.2
Identities = 16/49 (32%), Positives = 23/49 (46%)
Frame = -3
Query: 224 NSRHFPRIAKLFP*DTMRRCHRSKFSALPSLIGRRLRHYSLRPQRILLT 78
N F R K P T R R +A+ + + H+ L+PQ +LLT
Sbjct: 92 NLSAFIRTKKALPESTCRYFLRQLAAAVQYMRANDVSHFDLKPQNLLLT 140
Database: fruitfly
Posted date: Oct 23, 2007 1:17 PM
Number of letters in database: 24,988,368
Number of sequences in database: 53,049
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 31,943,876
Number of Sequences: 53049
Number of extensions: 670459
Number of successful extensions: 2869
Number of sequences better than 10.0: 27
Number of HSP's better than 10.0 without gapping: 2566
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2852
length of database: 24,988,368
effective HSP length: 83
effective length of database: 20,585,301
effective search space used: 3128965752
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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