Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= ceN-4110
(657 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
BC127603-1|AAI27604.1| 829|Homo sapiens kinase suppressor of ra... 235 1e-61
BC107107-1|AAI07108.1| 827|Homo sapiens KSR2 protein protein. 235 1e-61
BC107106-1|AAI07107.1| 827|Homo sapiens KSR2 protein protein. 235 1e-61
AY345972-1|AAQ24226.1| 829|Homo sapiens kinase suppressor of Ra... 235 1e-61
U43586-1|AAC50354.1| 635|Homo sapiens KSR1 protein. 222 8e-58
M95712-1|AAA35609.2| 766|Homo sapiens B-raf protein protein. 157 2e-38
M21001-1|AAA96495.1| 328|Homo sapiens B-raf protein protein. 157 2e-38
BC112079-1|AAI12080.1| 766|Homo sapiens v-raf murine sarcoma vi... 157 2e-38
BC101757-1|AAI01758.1| 766|Homo sapiens v-raf murine sarcoma vi... 157 2e-38
AY803272-1|AAW30454.1| 1492|Homo sapiens AKAP9-BRAF fusion prote... 157 2e-38
AC006344-3|AAD43193.1| 651|Homo sapiens WUGSC:H_DJ0726N20.3 pro... 157 2e-38
X03484-1|CAA27204.1| 648|Homo sapiens protein ( Human mRNA for ... 154 2e-37
L00212-1|AAA60247.1| 421|Homo sapiens RAF1 protein. 154 2e-37
BC018119-1|AAH18119.1| 648|Homo sapiens v-raf-1 murine leukemia... 154 2e-37
AY271661-1|AAP03432.1| 648|Homo sapiens v-raf-1 murine leukemia... 154 2e-37
Z84466-8|CAI42468.1| 606|Homo sapiens v-raf murine sarcoma 3611... 150 4e-36
X04790-1|CAA28476.1| 606|Homo sapiens protein ( Human mRNA for ... 150 4e-36
U01337-1|AAB03517.1| 606|Homo sapiens Ser/Thr protein kinase pr... 150 4e-36
L24038-1|AAA65219.1| 606|Homo sapiens ARAF1 protein. 150 4e-36
BT019864-1|AAV38667.1| 606|Homo sapiens v-raf murine sarcoma 36... 150 4e-36
BC007514-1|AAH07514.1| 609|Homo sapiens ARAF protein protein. 150 4e-36
BC002466-1|AAH02466.1| 606|Homo sapiens v-raf murine sarcoma 36... 150 4e-36
M13829-1|AAB08754.1| 298|Homo sapiens raf related protein protein. 145 1e-34
BC032787-1|AAH32787.1| 476|Homo sapiens calcium/calmodulin-depe... 91 3e-18
AY212935-1|AAP29964.1| 460|Homo sapiens CLICK III protein. 91 3e-18
AL049688-1|CAB41259.1| 481|Homo sapiens hypothetical protein pr... 91 3e-18
AL023754-3|CAI19991.1| 476|Homo sapiens calcium/calmodulin-depe... 91 3e-18
AF428261-1|AAL28100.1| 476|Homo sapiens calcium/calmodulin-depe... 91 3e-18
BC035745-1|AAH35745.1| 385|Homo sapiens calcium/calmodulin-depe... 89 1e-17
AL731559-2|CAI14675.1| 385|Homo sapiens calcium/calmodulin-depe... 89 1e-17
AL731559-1|CAI14674.1| 357|Homo sapiens calcium/calmodulin-depe... 89 1e-17
AL512783-2|CAH74036.1| 385|Homo sapiens calcium/calmodulin-depe... 89 1e-17
AL512783-1|CAH74035.1| 357|Homo sapiens calcium/calmodulin-depe... 89 1e-17
AL512284-2|CAH71694.1| 385|Homo sapiens calcium/calmodulin-depe... 89 1e-17
AL512284-1|CAH71693.1| 357|Homo sapiens calcium/calmodulin-depe... 89 1e-17
AL391314-2|CAI14410.1| 385|Homo sapiens calcium/calmodulin-depe... 89 1e-17
AL391314-1|CAI14409.1| 357|Homo sapiens calcium/calmodulin-depe... 89 1e-17
AF286366-1|AAG00534.1| 357|Homo sapiens CamKI-like protein kina... 89 1e-17
AB081726-1|BAC19846.1| 385|Homo sapiens CaM-kinase I delta prot... 89 1e-17
BC133706-1|AAI33707.1| 1104|Homo sapiens MAP3K9 protein protein. 88 3e-17
BC111407-1|AAI11408.1| 1103|Homo sapiens MAP3K9 protein protein. 88 3e-17
AY327900-1|AAQ23054.1| 1104|Homo sapiens mixed-lineage protein k... 88 3e-17
AF251442-1|AAG44591.1| 1066|Homo sapiens mixed lineage kinase ML... 88 3e-17
BC032865-1|AAH32865.1| 843|Homo sapiens TNNI3K protein protein. 85 2e-16
DQ822519-1|ABG46944.1| 835|Homo sapiens TNNI3 interacting kinas... 85 3e-16
BX470253-1|CAI16293.1| 835|Homo sapiens TNNI3 interacting kinas... 85 3e-16
BC117262-1|AAI17263.1| 835|Homo sapiens TNNI3 interacting kinas... 85 3e-16
BC113539-1|AAI13540.1| 835|Homo sapiens TNNI3 interacting kinas... 85 3e-16
AY303691-1|AAP72030.1| 835|Homo sapiens cardiac ankyrin repeat ... 85 3e-16
AF116826-1|AAD29632.1| 835|Homo sapiens putative protein-tyrosi... 85 3e-16
AB208941-1|BAD92178.1| 941|Homo sapiens TNNI3 interacting kinas... 85 3e-16
AB001872-1|BAA24817.1| 966|Homo sapiens leucine zipper bearing ... 83 8e-16
BC062616-1|AAH62616.1| 424|Homo sapiens protein serine kinase H... 83 1e-15
AJ272212-1|CAB91984.1| 424|Homo sapiens protein serine kinase p... 83 1e-15
Z48615-1|CAA88531.1| 953|Homo sapiens serine/threonine kinase w... 82 2e-15
X90846-1|CAA62351.1| 954|Homo sapiens mixed lineage kinase 2 pr... 82 2e-15
U07358-1|AAA67343.1| 859|Homo sapiens serine/threonine protein ... 81 5e-15
BC050050-1|AAH50050.1| 567|Homo sapiens MAP3K12 protein protein. 81 5e-15
BC001401-1|AAH01401.1| 455|Homo sapiens sterile alpha motif and... 81 5e-15
AF480462-1|AAL85892.1| 455|Homo sapiens mixed lineage kinase-re... 81 5e-15
AF480461-1|AAL85891.1| 800|Homo sapiens mixed lineage kinase-re... 81 5e-15
AF465843-1|AAO33376.1| 312|Homo sapiens cervical cancer suppres... 81 5e-15
AF325454-1|AAK11615.1| 455|Homo sapiens mixed lineage kinase pr... 81 5e-15
AF283475-1|AAL67158.1| 859|Homo sapiens zipper protein kinase p... 81 5e-15
AF251441-1|AAF65822.1| 800|Homo sapiens sterile-alpha motif and... 81 5e-15
AF238255-1|AAF63490.1| 800|Homo sapiens mixed lineage kinase ZA... 81 5e-15
AB208974-1|BAD92211.1| 845|Homo sapiens Plaucible mixed-lineage... 81 5e-15
AB049734-1|BAB16445.1| 455|Homo sapiens MLTK-beta protein. 81 5e-15
AB049733-1|BAB16444.1| 800|Homo sapiens MLTK-alpha protein. 81 5e-15
AB030034-1|BAB12040.1| 800|Homo sapiens plaucible mixed-lineage... 81 5e-15
BC035782-1|AAH35782.1| 661|Homo sapiens TNK1 protein protein. 80 6e-15
AF097738-1|AAC99412.1| 661|Homo sapiens non-receptor tyosine ki... 80 6e-15
AC013461-1|AAX93067.1| 400|Homo sapiens unknown protein. 79 1e-14
U43408-1|AAC50427.1| 666|Homo sapiens tyrosine kinase protein. 78 2e-14
M95936-1|AAA58364.1| 481|Homo sapiens protein serine/threonine ... 78 3e-14
M77198-1|AAA36585.1| 520|Homo sapiens rac protein kinase-beta p... 78 3e-14
BC120994-1|AAI20995.1| 481|Homo sapiens v-akt murine thymoma vi... 78 3e-14
Z98752-8|CAC18509.1| 367|Homo sapiens serum/glucocorticoid regu... 77 4e-14
Z98752-7|CAI42315.1| 366|Homo sapiens serum/glucocorticoid regu... 77 4e-14
Z98752-5|CAI42312.1| 427|Homo sapiens serum/glucocorticoid regu... 77 4e-14
U07747-1|AAA19647.1| 847|Homo sapiens serine/threonine protein ... 77 4e-14
L32976-1|AAA59859.1| 847|Homo sapiens protein kinase protein. 77 4e-14
BC065511-1|AAH65511.1| 367|Homo sapiens SGK2 protein protein. 77 4e-14
BC064543-1|AAH64543.1| 847|Homo sapiens mitogen-activated prote... 77 4e-14
BC014037-1|AAH14037.3| 367|Homo sapiens serum/glucocorticoid re... 77 4e-14
BC011263-1|AAH11263.1| 847|Homo sapiens mitogen-activated prote... 77 4e-14
AK222781-1|BAD96501.1| 847|Homo sapiens mitogen-activated prote... 77 4e-14
AF186470-1|AAG17012.1| 427|Homo sapiens protein kinase protein. 77 4e-14
AF169034-1|AAF12757.2| 367|Homo sapiens protein kinase protein. 77 4e-14
BC063885-1|AAH63885.1| 708|Homo sapiens NIMA (never in mitosis ... 77 6e-14
AL139082-5|CAI12892.2| 708|Homo sapiens NIMA (never in mitosis ... 77 6e-14
Z15114-1|CAA78820.1| 536|Homo sapiens protein kinase C gamma pr... 77 7e-14
BC073140-1|AAH73140.1| 414|Homo sapiens MAP kinase interacting ... 77 7e-14
BC047876-1|AAH47876.1| 697|Homo sapiens protein kinase C, gamma... 77 7e-14
AY987010-1|AAX88805.1| 393|Homo sapiens serum/glucocorticoid re... 77 7e-14
AL137565-1|CAB70816.1| 316|Homo sapiens hypothetical protein pr... 77 7e-14
AF345987-1|AAK13533.1| 697|Homo sapiens protein kinase C gamma ... 77 7e-14
AF237776-1|AAG26337.1| 414|Homo sapiens MAP kinase-interacting ... 77 7e-14
AF237775-1|AAG26336.1| 465|Homo sapiens MAP kinase-interacting ... 77 7e-14
AC007136-1|AAD21217.1| 472|Homo sapiens Putative map kinase int... 77 7e-14
D79997-1|BAA11492.2| 656|Homo sapiens KIAA0175 protein. 76 1e-13
BC126182-1|AAI26183.1| 385|Homo sapiens protein serine kinase H... 76 1e-13
BC126180-1|AAI26181.1| 385|Homo sapiens protein serine kinase H... 76 1e-13
BC031231-1|AAH31231.1| 514|Homo sapiens serine/threonine kinase... 76 1e-13
BC014039-1|AAH14039.1| 651|Homo sapiens maternal embryonic leuc... 76 1e-13
AY037806-1|AAK59985.1| 385|Homo sapiens serine/threonine kinase... 76 1e-13
AL442063-1|CAI16995.2| 651|Homo sapiens maternal embryonic leuc... 76 1e-13
AL354932-1|CAI11034.2| 651|Homo sapiens maternal embryonic leuc... 76 1e-13
AK222811-1|BAD96531.1| 651|Homo sapiens maternal embryonic leuc... 76 1e-13
AK093251-1|BAC04109.1| 514|Homo sapiens protein ( Homo sapiens ... 76 1e-13
AJ303380-1|CAC29064.1| 514|Homo sapiens serine/threonine kinase... 76 1e-13
AF125532-1|AAF17226.1| 414|Homo sapiens map kinase-interacting ... 76 1e-13
X73458-1|CAA51837.1| 603|Homo sapiens protein kinase protein. 76 1e-13
X52479-1|CAA36718.1| 672|Homo sapiens protein ( Human PKC alpha... 76 1e-13
U01038-1|AAA56634.1| 603|Homo sapiens pLK protein. 76 1e-13
L19559-1|AAA36659.1| 603|Homo sapiens protein kinase protein. 76 1e-13
BC109274-1|AAI09275.1| 672|Homo sapiens protein kinase C, alpha... 76 1e-13
BC109273-1|AAI09274.1| 672|Homo sapiens protein kinase C, alpha... 76 1e-13
BC014846-1|AAH14846.1| 603|Homo sapiens polo-like kinase 1 (Dro... 76 1e-13
BC003002-1|AAH03002.1| 603|Homo sapiens polo-like kinase 1 (Dro... 76 1e-13
BC002369-1|AAH02369.1| 603|Homo sapiens polo-like kinase 1 (Dro... 76 1e-13
AY633609-1|AAV33302.1| 672|Homo sapiens aging-associated gene 6... 76 1e-13
AL133380-4|CAI23046.1| 1036|Homo sapiens mixed lineage kinase 4 ... 75 2e-13
AL133380-3|CAI23045.1| 570|Homo sapiens mixed lineage kinase 4 ... 75 2e-13
L41816-1|AAA99458.1| 370|Homo sapiens cam kinase I protein. 75 3e-13
BT020098-1|AAV38901.1| 367|Homo sapiens serum/glucocorticoid re... 75 3e-13
BC106755-1|AAI06756.1| 370|Homo sapiens calcium/calmodulin-depe... 75 3e-13
BC106754-1|AAI06755.1| 370|Homo sapiens calcium/calmodulin-depe... 75 3e-13
X75932-1|CAA53536.1| 603|Homo sapiens Serine/Threonine protein ... 74 4e-13
AF045458-1|AAC32326.1| 1050|Homo sapiens serine/threonine kinase... 74 4e-13
AB018265-1|BAA34442.2| 1066|Homo sapiens KIAA0722 protein protein. 74 4e-13
U63721-3|AAC13886.1| 633|Homo sapiens LIM-kinase protein. 74 5e-13
U63721-2|AAC13885.1| 647|Homo sapiens LIM-kinase protein. 74 5e-13
U62293-2|AAB17546.1| 633|Homo sapiens alternatively spliced LIM... 74 5e-13
U62293-1|AAB17545.1| 647|Homo sapiens LIM-kinase1 protein. 74 5e-13
D26309-1|BAA05371.1| 647|Homo sapiens LIM kinase protein. 74 5e-13
CR536581-1|CAG38818.1| 429|Homo sapiens SGKL protein. 74 5e-13
BC015326-1|AAH15326.1| 496|Homo sapiens serum/glucocorticoid re... 74 5e-13
AK223523-1|BAD97243.1| 496|Homo sapiens serum/glucocorticoid re... 74 5e-13
AF169035-1|AAF12758.1| 429|Homo sapiens protein kinase protein. 74 5e-13
AC005057-3|AAS07438.1| 596|Homo sapiens unknown protein. 74 5e-13
L13738-1|AAA53570.2| 1036|Homo sapiens activated p21cdc42Hs kina... 73 9e-13
BC028164-1|AAH28164.1| 528|Homo sapiens TNK2 protein protein. 73 9e-13
AK131539-1|BAD18675.1| 1086|Homo sapiens protein ( Homo sapiens ... 73 9e-13
AB209338-1|BAD92575.1| 400|Homo sapiens Hypothetical protein FL... 73 9e-13
AB183427-1|BAF73615.1| 619|Homo sapiens maternal embryonic leuc... 73 9e-13
X07109-1|CAA30130.1| 673|Homo sapiens protein ( Human mRNA for ... 73 1e-12
X06318-1|CAA29634.1| 671|Homo sapiens protein ( Human mRNA for ... 73 1e-12
M13975-1|AAA60095.1| 673|Homo sapiens protein kinase C beta-II ... 73 1e-12
BC036472-1|AAH36472.1| 673|Homo sapiens protein kinase C, beta ... 73 1e-12
AF085233-1|AAF27051.2| 496|Homo sapiens SGK-like protein SGKL p... 73 1e-12
AC002299-2|AAB97934.1| 496|Homo sapiens Protein kinase C beta (... 73 1e-12
AC002299-1|AAB97933.1| 494|Homo sapiens Protein kinase C beta (... 73 1e-12
L07861-1|AAA03175.1| 676|Homo sapiens protein kinase C-delta 13... 72 2e-12
L07860-1|AAA03176.1| 676|Homo sapiens protein kinase C-delta 13... 72 2e-12
D10495-1|BAA01381.1| 626|Homo sapiens protein kinase C delta-ty... 72 2e-12
BC043350-1|AAH43350.1| 676|Homo sapiens protein kinase C, delta... 72 2e-12
BC034988-1|AAH34988.1| 1036|Homo sapiens ULK2 protein protein. 72 2e-12
AK098831-1|BAC05426.1| 439|Homo sapiens protein ( Homo sapiens ... 72 2e-12
AB014523-1|BAA31598.2| 1100|Homo sapiens KIAA0623 protein protein. 72 2e-12
Z98049-1|CAI20579.1| 733|Homo sapiens ribosomal protein S6 kina... 71 3e-12
X85106-1|CAA59427.1| 733|Homo sapiens ribosomal S6 kinase protein. 71 3e-12
M55284-1|AAA60100.1| 682|Homo sapiens protein kinase C-L protein. 71 3e-12
BC020479-1|AAH20479.1| 466|Homo sapiens AKT3 protein protein. 71 3e-12
BC002363-1|AAH02363.1| 733|Homo sapiens ribosomal protein S6 ki... 71 3e-12
AY005799-1|AAF91073.1| 465|Homo sapiens protein kinase B gamma ... 71 3e-12
AL662889-3|CAH73073.1| 479|Homo sapiens v-akt murine thymoma vi... 71 3e-12
AL662889-2|CAH73072.1| 465|Homo sapiens v-akt murine thymoma vi... 71 3e-12
AL592151-2|CAH72892.1| 479|Homo sapiens v-akt murine thymoma vi... 71 3e-12
AL592151-1|CAH72891.1| 465|Homo sapiens v-akt murine thymoma vi... 71 3e-12
AL591721-2|CAH71867.1| 479|Homo sapiens v-akt murine thymoma vi... 71 3e-12
AL591721-1|CAH71866.1| 465|Homo sapiens v-akt murine thymoma vi... 71 3e-12
AL022069-2|CAI19651.1| 733|Homo sapiens ribosomal protein S6 ki... 71 3e-12
AJ311798-1|CAC84640.1| 1036|Homo sapiens mixed lineage kinase 4b... 71 3e-12
AJ311797-1|CAC84639.1| 570|Homo sapiens mixed lineage kinase 4a... 71 3e-12
AJ245709-1|CAB53537.1| 479|Homo sapiens Akt-3 protein protein. 71 3e-12
AF135794-1|AAD24196.1| 479|Homo sapiens AKT3 protein kinase pro... 71 3e-12
AF124141-1|AAD29089.1| 479|Homo sapiens protein kinase B gamma ... 71 3e-12
AF085234-1|AAL40392.1| 479|Homo sapiens STK-2 protein. 71 3e-12
AB209116-1|BAD92353.1| 806|Homo sapiens ribosomal protein S6 ki... 71 3e-12
L07598-1|AAC82496.1| 540|Homo sapiens ribosomal protein S6 kina... 71 4e-12
U33053-1|AAC50209.1| 942|Homo sapiens PRK1 protein. 71 5e-12
S75546-1|AAB33345.1| 942|Homo sapiens protein kinase PRK1 protein. 71 5e-12
L07868-1|AAB59446.1| 1308|Homo sapiens receptor tyrosine kinase ... 71 5e-12
D26181-1|BAA05169.1| 942|Homo sapiens PKN protein. 71 5e-12
BC125199-1|AAI25200.1| 936|Homo sapiens PKN2 protein protein. 71 5e-12
BC112199-1|AAI12200.1| 1308|Homo sapiens v-erb-a erythroblastic ... 71 5e-12
BC040061-1|AAH40061.1| 942|Homo sapiens protein kinase N1 protein. 71 5e-12
BC039695-1|AAH39695.1| 1129|Homo sapiens JAK2 protein protein. 71 5e-12
AY973034-1|AAY22962.1| 1132|Homo sapiens Janus kinase 2 protein. 71 5e-12
AL161450-1|CAD13329.1| 1132|Homo sapiens Janus kinase 2 (a prote... 71 5e-12
AF058925-1|AAC23982.1| 1132|Homo sapiens Jak2 kinase protein. 71 5e-12
AF005216-1|AAB82092.1| 1132|Homo sapiens receptor-associated tyr... 71 5e-12
AF001362-1|AAC23653.1| 1132|Homo sapiens Jak2 kinase protein. 71 5e-12
AB209697-1|BAD92934.1| 892|Homo sapiens v-erb-a erythroblastic ... 71 5e-12
Z84486-1|CAI21678.1| 526|Homo sapiens serum/glucocorticoid regu... 70 6e-12
Y10032-1|CAA71138.1| 431|Homo sapiens serine/threonine protein ... 70 6e-12
U33052-1|AAC50208.1| 984|Homo sapiens PRK2 protein. 70 6e-12
S75548-1|AAB33346.1| 984|Homo sapiens protein kinase PRK2 protein. 70 6e-12
L07032-1|AAA60101.1| 706|Homo sapiens protein kinase C-theta pr... 70 6e-12
L01087-1|AAA75571.1| 706|Homo sapiens protein kinase C-theta pr... 70 6e-12
BC129951-1|AAI29952.1| 854|Homo sapiens MAP3K6 protein protein. 70 6e-12
BC129950-1|AAI29951.1| 854|Homo sapiens MAP3K6 protein protein. 70 6e-12
BC113359-1|AAI13360.1| 706|Homo sapiens protein kinase C, theta... 70 6e-12
BC109032-1|AAI09033.1| 441|Homo sapiens MAP3K6 protein protein. 70 6e-12
BC101465-1|AAI01466.1| 706|Homo sapiens protein kinase C, theta... 70 6e-12
BC015914-1|AAH15914.1| 797|Homo sapiens MAP3K6 protein protein. 70 6e-12
BC001263-1|AAH01263.1| 431|Homo sapiens serum/glucocorticoid re... 70 6e-12
AL663123-5|CAI14778.1| 797|Homo sapiens mitogen-activated prote... 70 6e-12
AL663123-4|CAM12869.1| 1288|Homo sapiens mitogen-activated prote... 70 6e-12
AL355881-2|CAH72579.1| 526|Homo sapiens serum/glucocorticoid re... 70 6e-12
AL158043-2|CAC12904.2| 706|Homo sapiens protein kinase C, theta... 70 6e-12
AL158043-1|CAI16127.1| 478|Homo sapiens protein kinase C, theta... 70 6e-12
AL137145-2|CAC10200.2| 706|Homo sapiens protein kinase C, theta... 70 6e-12
AL137145-1|CAI15756.1| 478|Homo sapiens protein kinase C, theta... 70 6e-12
AL136381-3|CAI23271.1| 984|Homo sapiens protein kinase N2 protein. 70 6e-12
AL135839-4|CAI19721.1| 526|Homo sapiens serum/glucocorticoid re... 70 6e-12
AL135839-3|CAI19720.1| 445|Homo sapiens serum/glucocorticoid re... 70 6e-12
AL135839-2|CAI19719.1| 431|Homo sapiens serum/glucocorticoid re... 70 6e-12
AL135839-1|CAI19718.1| 421|Homo sapiens serum/glucocorticoid re... 70 6e-12
AL023754-2|CAI19990.1| 245|Homo sapiens calcium/calmodulin-depe... 70 6e-12
AJ000512-1|CAA04146.1| 431|Homo sapiens serine/threonine protei... 70 6e-12
AF153609-1|AAD41091.1| 431|Homo sapiens serine/threonine protei... 70 6e-12
AF100318-1|AAD05304.1| 1011|Homo sapiens mitogen-activated prote... 70 6e-12
AB208805-1|BAD92042.1| 1192|Homo sapiens mitogen-activated prote... 70 6e-12
AB167411-1|BAD12485.1| 1288|Homo sapiens apoptosis signal-regula... 70 6e-12
U22322-1|AAC50116.1| 505|Homo sapiens Rak protein. 70 8e-12
U00803-1|AAA18284.1| 505|Homo sapiens SRC-like tyrosine kinase ... 70 8e-12
BC012916-1|AAH12916.1| 505|Homo sapiens fyn-related kinase prot... 70 8e-12
AL357141-2|CAI16469.1| 505|Homo sapiens fyn-related kinase prot... 70 8e-12
AL121963-8|CAB87592.2| 505|Homo sapiens fyn-related kinase prot... 70 8e-12
L33881-1|AAB17011.1| 587|Homo sapiens protein kinase C iota pro... 69 1e-11
L18964-1|AAA60171.1| 587|Homo sapiens protein kinase C iota pro... 69 1e-11
D50863-1|BAA09459.1| 626|Homo sapiens TESK1 protein. 69 1e-11
BC067130-1|AAH67130.1| 626|Homo sapiens TESK1 protein protein. 69 1e-11
BC038448-1|AAH38448.1| 626|Homo sapiens TESK1 protein protein. 69 1e-11
BC022016-1|AAH22016.3| 587|Homo sapiens protein kinase C, iota ... 69 1e-11
BC017575-1|AAH17575.1| 476|Homo sapiens CHK1 checkpoint homolog... 69 1e-11
BC004202-1|AAH04202.1| 476|Homo sapiens CHEK1 protein protein. 69 1e-11
AL357874-1|CAI13441.1| 626|Homo sapiens testis-specific kinase ... 69 1e-11
AF527555-1|AAM78553.1| 476|Homo sapiens CHK1 checkpoint homolog... 69 1e-11
AF032874-1|AAB88852.1| 476|Homo sapiens protein kinase protein. 69 1e-11
AF016582-1|AAC51736.1| 476|Homo sapiens Chk1 protein. 69 1e-11
AB032387-1|BAA84577.1| 476|Homo sapiens checkpoint kinase protein. 69 1e-11
M63167-1|AAA36539.1| 480|Homo sapiens rac protein kinase-alpha ... 69 1e-11
BC121154-1|AAI21155.1| 465|Homo sapiens v-akt murine thymoma vi... 69 1e-11
BC084538-1|AAH84538.1| 480|Homo sapiens v-akt murine thymoma vi... 69 1e-11
BC037268-1|AAH37268.1| 683|Homo sapiens protein kinase C, eta p... 69 1e-11
BC000479-1|AAH00479.1| 480|Homo sapiens v-akt murine thymoma vi... 69 1e-11
AL390029-2|CAI15721.1| 740|Homo sapiens doublecortin and CaM ki... 69 1e-11
AL390029-1|CAI15720.1| 729|Homo sapiens doublecortin and CaM ki... 69 1e-11
AL160392-2|CAH70261.1| 740|Homo sapiens doublecortin and CaM ki... 69 1e-11
AL160392-1|CAH70262.1| 729|Homo sapiens doublecortin and CaM ki... 69 1e-11
AL157760-4|CAH70170.1| 433|Homo sapiens doublecortin and CaM ki... 69 1e-11
AL157760-2|CAH70167.1| 740|Homo sapiens doublecortin and CaM ki... 69 1e-11
AL157760-1|CAH70168.1| 729|Homo sapiens doublecortin and CaM ki... 69 1e-11
AL157694-2|CAH70656.1| 740|Homo sapiens doublecortin and CaM ki... 69 1e-11
AL157694-1|CAH70657.1| 729|Homo sapiens doublecortin and CaM ki... 69 1e-11
AF283830-1|AAL55732.1| 480|Homo sapiens AKT1 protein. 69 1e-11
AB002367-1|BAA20824.2| 794|Homo sapiens KIAA0369 protein. 69 1e-11
D45906-1|BAA08312.1| 638|Homo sapiens LIMK-2 protein. 69 2e-11
CR456513-1|CAG30399.1| 638|Homo sapiens LIMK2 protein. 69 2e-11
BC028587-1|AAH28587.1| 482|Homo sapiens NEK11 protein protein. 69 2e-11
BC017187-1|AAH17187.1| 549|Homo sapiens ribosomal protein S6 ki... 69 2e-11
BC013051-1|AAH13051.1| 686|Homo sapiens LIM domain kinase 2 pro... 69 2e-11
AF090421-1|AAC69577.1| 809|Homo sapiens ribosome S6 protein kin... 69 2e-11
AF080000-1|AAD23915.1| 802|Homo sapiens RSK-like protein kinase... 69 2e-11
AF074393-1|AAC31171.1| 802|Homo sapiens nuclear mitogen- and st... 69 2e-11
AC002073-3|AAB54055.1| 733|Homo sapiens Lim kinase protein. 69 2e-11
AC002073-2|AAB54056.1| 638|Homo sapiens Lim Kinase protein. 69 2e-11
AB071997-1|BAC06351.1| 470|Homo sapiens NIMA-related kinase 11S... 69 2e-11
AB071996-1|BAC06350.1| 645|Homo sapiens NIMA-related kinase 11L... 69 2e-11
X90870-1|CAA62378.1| 458|Homo sapiens myosin-light-chain kinase... 68 3e-11
X80229-1|CAA56515.1| 479|Homo sapiens serine/threonine protein ... 68 3e-11
U48959-1|AAC18423.2| 1914|Homo sapiens myosin light chain kinase... 68 3e-11
M97639-1|AAA60276.1| 943|Homo sapiens transmembrane receptor pr... 68 3e-11
BC130522-1|AAI30523.1| 943|Homo sapiens receptor tyrosine kinas... 68 3e-11
BC004553-1|AAH04553.1| 540|Homo sapiens receptor-interacting se... 68 3e-11
AY358814-1|AAQ89173.1| 540|Homo sapiens RIPK2 protein. 68 3e-11
AY339601-1|AAQ02673.1| 1914|Homo sapiens long myosin light chain... 68 3e-11
AL928802-2|CAI17303.1| 943|Homo sapiens receptor tyrosine kinas... 68 3e-11
AL928802-1|CAI17302.1| 704|Homo sapiens receptor tyrosine kinas... 68 3e-11
AL591214-1|CAH71099.1| 704|Homo sapiens receptor tyrosine kinas... 68 3e-11
AL583841-2|CAI15694.1| 943|Homo sapiens receptor tyrosine kinas... 68 3e-11
AL583841-1|CAI15693.1| 704|Homo sapiens receptor tyrosine kinas... 68 3e-11
AL391219-1|CAH70208.1| 943|Homo sapiens receptor tyrosine kinas... 68 3e-11
AF294796-1|AAG01184.2| 910|Homo sapiens ROR2 protein protein. 68 3e-11
AF078530-1|AAC27722.1| 540|Homo sapiens receptor interacting pr... 68 3e-11
AF069601-1|AAD15921.2| 1845|Homo sapiens myosin light chain kina... 68 3e-11
AF064824-1|AAC25668.1| 540|Homo sapiens CARD-containing ICE ass... 68 3e-11
AF027706-1|AAC34970.1| 540|Homo sapiens serine/threonine kinase... 68 3e-11
AC004003-1|AAC24561.1| 540|Homo sapiens WUGSC:H_RG437L15.1 prot... 68 3e-11
AB209475-1|BAD92712.1| 461|Homo sapiens protein kinase C, alpha... 68 3e-11
AB209154-1|BAD92391.1| 919|Homo sapiens Tyrosine-protein kinase... 68 3e-11
AB037663-1|BAB21504.1| 992|Homo sapiens myosin light chain kina... 68 3e-11
BC006106-1|AAH06106.3| 482|Homo sapiens ribosomal protein S6 ki... 68 3e-11
BC000094-1|AAH00094.3| 482|Homo sapiens ribosomal protein S6 ki... 68 3e-11
AY355461-1|AAQ84219.1| 347|Homo sapiens MNK1-like kinase 1b pro... 68 3e-11
AL136373-5|CAI14764.1| 424|Homo sapiens MAP kinase interacting ... 68 3e-11
AF099739-1|AAD20990.1| 482|Homo sapiens S6 kinase-related kinas... 68 3e-11
AF076931-1|AAD46063.1| 482|Homo sapiens serine/threonine kinase... 68 3e-11
AF042838-1|AAC97073.1| 1495|Homo sapiens MEK kinase 1 protein. 68 3e-11
AB019245-1|BAA37145.1| 481|Homo sapiens S6 kinase b protein. 68 3e-11
AB016869-1|BAA34402.1| 495|Homo sapiens p70 ribosomal S6 kinase... 68 3e-11
AB000409-1|BAA19885.1| 424|Homo sapiens MNK1 protein. 68 3e-11
M64174-1|AAA36527.1| 1142|Homo sapiens protein-tyrosine kinase p... 67 4e-11
L27071-1|AAA74557.1| 527|Homo sapiens tyrosine kinase protein. 67 4e-11
L07597-1|AAC82497.1| 735|Homo sapiens ribosomal protein S6 kina... 67 4e-11
BC132729-1|AAI32730.1| 1154|Homo sapiens Janus kinase 1 (a prote... 67 4e-11
BC014966-1|AAH14966.1| 735|Homo sapiens ribosomal protein S6 ki... 67 4e-11
AY524045-1|AAS94254.1| 540|Homo sapiens GIG30 protein. 67 4e-11
AL627313-6|CAI14649.1| 735|Homo sapiens ribosomal protein S6 ki... 67 4e-11
AK131198-1|BAD18393.1| 706|Homo sapiens protein ( Homo sapiens ... 67 4e-11
AJ271722-1|CAB71146.1| 714|Homo sapiens putative serine/threoni... 67 4e-11
AB209057-1|BAD92294.1| 1154|Homo sapiens janus kinase 1 variant ... 67 4e-11
X61037-1|CAA43372.1| 417|Homo sapiens human protein kinase B p... 67 6e-11
U34379-1|AAB60412.1| 527|Homo sapiens tyrosine kinase protein. 67 6e-11
U08316-1|AAA81952.1| 740|Homo sapiens insulin-stimulated protei... 67 6e-11
M35296-1|AAA35553.1| 1182|Homo sapiens protein ( Human tyrosine ... 67 6e-11
L07599-1|AAC82495.1| 580|Homo sapiens ribosomal protein S6 kina... 67 6e-11
DQ009672-1|AAY16984.1| 1182|Homo sapiens v-abl Abelson murine le... 67 6e-11
BX538317-1|CAD98092.1| 1092|Homo sapiens hypothetical protein pr... 67 6e-11
BC096303-1|AAH96303.1| 740|Homo sapiens ribosomal protein S6 ki... 67 6e-11
BC096302-1|AAH96302.1| 740|Homo sapiens ribosomal protein S6 ki... 67 6e-11
BC096301-1|AAH96301.1| 740|Homo sapiens ribosomal protein S6 ki... 67 6e-11
BC065912-1|AAH65912.1| 1167|Homo sapiens ABL2 protein protein. 67 6e-11
BC064422-1|AAH64422.1| 241|Homo sapiens PNCK protein protein. 67 6e-11
BC047896-1|AAH47896.1| 524|Homo sapiens RPS6KA4 protein protein. 67 6e-11
BC028079-1|AAH28079.1| 556|Homo sapiens RPS6KA4 protein protein. 67 6e-11
BC019916-1|AAH19916.2| 506|Homo sapiens NIMA (never in mitosis ... 67 6e-11
AL807772-3|CAI39687.1| 740|Homo sapiens ribosomal protein S6 ki... 67 6e-11
AL732366-2|CAI40548.1| 740|Homo sapiens ribosomal protein S6 ki... 67 6e-11
AL512326-6|CAI13570.1| 1182|Homo sapiens v-abl Abelson murine le... 67 6e-11
AL512326-2|CAI13566.1| 1064|Homo sapiens v-abl Abelson murine le... 67 6e-11
AL359179-2|CAI15585.1| 1182|Homo sapiens v-abl Abelson murine le... 67 6e-11
AL359179-1|CAI15584.1| 1064|Homo sapiens v-abl Abelson murine le... 67 6e-11
AL139132-5|CAH70925.1| 1182|Homo sapiens v-abl Abelson murine le... 67 6e-11
AL139132-1|CAH70921.1| 1064|Homo sapiens v-abl Abelson murine le... 67 6e-11
AL139082-7|CAI12895.1| 507|Homo sapiens NIMA (never in mitosis ... 67 6e-11
AK223561-1|BAD97281.1| 765|Homo sapiens ribosomal protein S6 ki... 67 6e-11
AK131359-1|BAD18511.1| 510|Homo sapiens protein ( Homo sapiens ... 67 6e-11
AJ010119-1|CAA09009.1| 772|Homo sapiens Ribosomal protein kinas... 67 6e-11
AF507907-1|AAM50515.1| 244|Homo sapiens testis-specific kinase-... 67 6e-11
AF074715-1|AAC67395.1| 705|Homo sapiens mitogen- and stress-act... 67 6e-11
AB208933-1|BAD92170.1| 806|Homo sapiens ribosomal protein S6 ki... 67 6e-11
AB102662-1|BAC81131.1| 726|Homo sapiens RPS6KA3 protein. 67 6e-11
AB072828-1|BAC15599.1| 489|Homo sapiens NIMA-related protein ki... 67 6e-11
X85337-1|CAA59685.1| 991|Homo sapiens myosin light chain kinase... 66 8e-11
U56998-1|AAC50637.1| 607|Homo sapiens putative serine/threonine... 66 8e-11
M60725-1|AAA36411.1| 502|Homo sapiens p70 ribosomal S6 kinase a... 66 8e-11
M60724-1|AAA36410.1| 525|Homo sapiens p70 ribosomal S6 kinase a... 66 8e-11
BC053365-1|AAH53365.1| 451|Homo sapiens RPS6KB1 protein protein. 66 8e-11
BC047865-1|AAH47865.1| 812|Homo sapiens MAP4K2 protein protein. 66 8e-11
BC013899-1|AAH13899.1| 646|Homo sapiens polo-like kinase 3 (Dro... 66 8e-11
AY764184-1|AAU88146.1| 646|Homo sapiens polo-like kinase 3 (Dro... 66 8e-11
AL592166-11|CAI13006.1| 646|Homo sapiens polo-like kinase 3 (Dr... 66 8e-11
AJ293866-1|CAC10659.1| 646|Homo sapiens FNK serine/threonine pr... 66 8e-11
AB209875-1|BAD93112.1| 621|Homo sapiens polo-like kinase 3 vari... 66 8e-11
Z29067-1|CAA82310.1| 459|Homo sapiens protein kinase protein. 66 1e-10
DQ201638-1|ABA27097.1| 527|Homo sapiens oxidative-stress respon... 66 1e-10
BC038504-1|AAH38504.1| 783|Homo sapiens SNF1-like kinase protein. 66 1e-10
BC036422-1|AAH36422.1| 436|Homo sapiens hypothetical protein MG... 66 1e-10
BC034511-1|AAH34511.1| 501|Homo sapiens PAK4 protein protein. 66 1e-10
BC025282-1|AAH25282.1| 591|Homo sapiens p21(CDKN1A)-activated k... 66 1e-10
BC011368-1|AAH11368.1| 591|Homo sapiens p21(CDKN1A)-activated k... 66 1e-10
BC008726-1|AAH08726.1| 527|Homo sapiens oxidative-stress respon... 66 1e-10
BC002921-1|AAH02921.1| 426|Homo sapiens p21(CDKN1A)-activated k... 66 1e-10
AK131076-1|BAC85126.1| 764|Homo sapiens FLJ00263 protein protein. 66 1e-10
AK074728-1|BAC11166.1| 240|Homo sapiens protein ( Homo sapiens ... 66 1e-10
AJ011855-1|CAA09820.1| 591|Homo sapiens PAK4 protein protein. 66 1e-10
AF005046-1|AAD01210.1| 591|Homo sapiens serine/threonine kinase... 66 1e-10
AB047786-1|BAD74070.1| 783|Homo sapiens serine/threonine protei... 66 1e-10
AB032968-1|BAA86456.1| 467|Homo sapiens KIAA1142 protein protein. 66 1e-10
AB017642-1|BAA75674.1| 527|Homo sapiens oxidative-stress respon... 66 1e-10
U07349-1|AAA20968.1| 819|Homo sapiens GC kinase protein. 66 1e-10
D86968-1|BAA13204.2| 1626|Homo sapiens KIAA0213 protein. 66 1e-10
BC146770-1|AAI46771.1| 1558|Homo sapiens mitogen-activated prote... 66 1e-10
BC126432-1|AAI26433.1| 454|Homo sapiens death-associated protei... 66 1e-10
BC126430-1|AAI26431.1| 454|Homo sapiens death-associated protei... 66 1e-10
AP001751-1|BAA95536.1| 786|Homo sapiens SNF1LK protein. 66 1e-10
AL035703-1|CAB81612.1| 1005|Homo sapiens EPH receptor A8 protein. 66 1e-10
AF099989-1|AAC72238.1| 547|Homo sapiens Ste-20 related kinase S... 66 1e-10
AF002715-1|AAB68804.1| 1607|Homo sapiens MAP kinase kinase kinas... 66 1e-10
AC067940-1|AAY24032.1| 363|Homo sapiens unknown protein. 66 1e-10
AB040892-1|BAA95983.1| 853|Homo sapiens KIAA1459 protein protein. 66 1e-10
AB022341-1|BAA81746.1| 454|Homo sapiens ZIP kinase protein. 66 1e-10
AB007144-1|BAA24955.1| 454|Homo sapiens ZIP-kinase protein. 66 1e-10
Z15108-1|CAA78813.1| 584|Homo sapiens protein kinase C zeta pro... 65 2e-10
X16416-1|CAA34438.1| 1130|Homo sapiens protein ( Human c-abl mRN... 65 2e-10
U07563-2|AAB60394.1| 1130|Homo sapiens proto-oncogene tyrosine-p... 65 2e-10
U07563-1|AAB60393.1| 1149|Homo sapiens proto-oncogene tyrosine-p... 65 2e-10
M14752-1|AAA51561.1| 1130|Homo sapiens ABL1 protein. 65 2e-10
L14283-1|AAA36488.1| 592|Homo sapiens protein kinase C zeta pro... 65 2e-10
DQ145721-1|AAZ38718.1| 1149|Homo sapiens v-abl Abelson murine le... 65 2e-10
BT007082-1|AAP35745.1| 592|Homo sapiens protein kinase C, zeta ... 65 2e-10
BC117451-1|AAI17452.1| 1149|Homo sapiens v-abl Abelson murine le... 65 2e-10
BC037303-1|AAH37303.1| 550|Homo sapiens PRKAA1 protein protein. 65 2e-10
BC014270-1|AAH14270.1| 592|Homo sapiens protein kinase C, zeta ... 65 2e-10
BC008884-1|AAH08884.1| 352|Homo sapiens TNK2 protein protein. 65 2e-10
BC008058-1|AAH08058.1| 592|Homo sapiens protein kinase C, zeta ... 65 2e-10
AL645703-1|CAI21535.1| 592|Homo sapiens protein kinase C, zeta ... 65 2e-10
AL590822-9|CAI12484.1| 592|Homo sapiens protein kinase C, zeta ... 65 2e-10
AL391845-5|CAI15438.1| 592|Homo sapiens protein kinase C, zeta ... 65 2e-10
AL359092-11|CAM45752.1| 1149|Homo sapiens v-abl Abelson murine l... 65 2e-10
AL161733-3|CAM45756.1| 1149|Homo sapiens v-abl Abelson murine le... 65 2e-10
AL161733-1|CAM45754.1| 1130|Homo sapiens v-abl Abelson murine le... 65 2e-10
AF030403-1|AAD01901.1| 547|Homo sapiens Ste20-like protein kina... 65 2e-10
AB209642-1|BAD92879.1| 949|Homo sapiens Proto-oncogene tyrosine... 65 2e-10
AB209456-1|BAD92693.1| 1167|Homo sapiens v-abl Abelson murine le... 65 2e-10
AB022017-1|BAA36547.1| 550|Homo sapiens AMP-activated protein k... 65 2e-10
Y13115-1|CAA73575.1| 970|Homo sapiens serine/threonine protein ... 65 2e-10
X75208-1|CAA53021.1| 998|Homo sapiens protein tyrosine kinase-r... 65 2e-10
BX538193-1|CAD98062.1| 329|Homo sapiens hypothetical protein pr... 65 2e-10
BC112101-1|AAI12102.1| 979|Homo sapiens NIMA related kinase 9 p... 65 2e-10
BC093881-1|AAH93881.1| 979|Homo sapiens NIMA (never in mitosis ... 65 2e-10
BC052968-1|AAH52968.1| 998|Homo sapiens EPH receptor B3 protein. 65 2e-10
AY424270-1|AAR29062.1| 1914|Homo sapiens myosin lignt chain poly... 65 2e-10
AY424269-1|AAR29061.1| 1845|Homo sapiens myosin light chain poly... 65 2e-10
AY080896-1|AAL87410.1| 979|Homo sapiens NIMA-family kinase NERC... 65 2e-10
AY048580-1|AAL05428.1| 979|Homo sapiens NIMA-related kinase Nek... 65 2e-10
AL136373-3|CAI14762.1| 329|Homo sapiens MAP kinase interacting ... 65 2e-10
AC007055-5|AAD31940.1| 312|Homo sapiens protein ( Homo sapiens ... 65 2e-10
AB082526-1|BAC02704.1| 1011|Homo sapiens KIAA1995 protein protein. 65 2e-10
X95425-1|CAA64700.1| 1037|Homo sapiens EHK-1 receptor tyrosine k... 64 3e-10
X54637-1|CAA38449.1| 1187|Homo sapiens protein ( Human tyk2 mRNA... 64 3e-10
U77129-1|AAB48435.1| 846|Homo sapiens KHS1 protein. 64 3e-10
L36644-1|AAA74245.1| 991|Homo sapiens receptor protein-tyrosine... 64 3e-10
BC117183-1|AAI17184.1| 926|Homo sapiens SNF1-like kinase 2 prot... 64 3e-10
BC114491-1|AAI14492.1| 1189|Homo sapiens NEK1 protein protein. 64 3e-10
BC113459-1|AAI13460.1| 926|Homo sapiens SNF1-like kinase 2 prot... 64 3e-10
BC101713-1|AAI01714.1| 631|Homo sapiens tec protein tyrosine ki... 64 3e-10
BC101711-1|AAI01712.1| 631|Homo sapiens tec protein tyrosine ki... 64 3e-10
BC036013-1|AAH36013.1| 846|Homo sapiens mitogen-activated prote... 64 3e-10
BC015147-1|AAH15147.1| 403|Homo sapiens Unknown (protein for IM... 64 3e-10
AY549314-1|AAS37680.1| 1187|Homo sapiens tyrosine kinase 2 protein. 64 3e-10
AB209375-1|BAD92612.1| 1017|Homo sapiens ephrin receptor EphA5 i... 64 3e-10
AB084424-1|BAB91442.1| 346|Homo sapiens KIAA0781 protein protein. 64 3e-10
AB067488-1|BAB67794.1| 1265|Homo sapiens KIAA1901 protein protein. 64 3e-10
AB029024-1|BAA83053.2| 467|Homo sapiens KIAA1101 protein protein. 64 3e-10
AB018324-1|BAA34501.3| 950|Homo sapiens KIAA0781 protein protein. 64 3e-10
D84212-1|BAA23592.1| 402|Homo sapiens aurora/IPL1-related kinas... 64 4e-10
BC111744-1|AAI11745.1| 984|Homo sapiens EPH receptor B1 protein. 64 4e-10
BC032709-1|AAH32709.1| 344|Homo sapiens AKT2 protein protein. 64 4e-10
AL834498-1|CAD39156.1| 716|Homo sapiens hypothetical protein pr... 64 4e-10
AC093748-1|AAY40983.1| 443|Homo sapiens unknown protein. 64 4e-10
AB209181-1|BAD92418.1| 796|Homo sapiens Hypothetical protein DK... 64 4e-10
AB183428-1|BAF73616.1| 580|Homo sapiens maternal embryonic luec... 64 4e-10
X76104-1|CAA53712.1| 1431|Homo sapiens DAP-kinase protein. 64 6e-10
DQ436495-1|ABD96827.1| 1430|Homo sapiens death-associated protei... 64 6e-10
BT006935-1|AAP35581.1| 367|Homo sapiens death-associated protei... 64 6e-10
BC113705-1|AAI13706.1| 692|Homo sapiens NIMA (never in mitosis ... 64 6e-10
BC113660-1|AAI13661.1| 1430|Homo sapiens death-associated protei... 64 6e-10
BC112240-1|AAI12241.1| 692|Homo sapiens NIMA-related kinase 8 p... 64 6e-10
BC027464-1|AAH27464.1| 403|Homo sapiens aurora kinase A protein. 64 6e-10
BC024179-1|AAH24179.1| 719|Homo sapiens p21(CDKN1A)-activated k... 64 6e-10
BC006423-1|AAH06423.1| 403|Homo sapiens aurora kinase A protein. 64 6e-10
BC002499-1|AAH02499.1| 403|Homo sapiens AURKA protein protein. 64 6e-10
BC001280-1|AAH01280.1| 403|Homo sapiens aurora kinase A protein. 64 6e-10
AY267371-1|AAP04006.1| 692|Homo sapiens NIMA-family kinase NEK8... 64 6e-10
AY242354-1|AAO88243.1| 692|Homo sapiens NIMA-related kinase 12a... 64 6e-10
AL596452-3|CAI41309.1| 1498|Homo sapiens mitogen-activated prote... 64 6e-10
AL596452-2|CAI41310.1| 1544|Homo sapiens mitogen-activated prote... 64 6e-10
AL591852-1|CAH71696.1| 1455|Homo sapiens death-associated protei... 64 6e-10
AL591045-2|CAH70639.1| 1498|Homo sapiens mitogen-activated prote... 64 6e-10
AL591045-1|CAH70640.1| 1544|Homo sapiens mitogen-activated prote... 64 6e-10
AL353612-1|CAI23529.1| 719|Homo sapiens p21(CDKN1A)-activated k... 64 6e-10
AL161787-1|CAH73544.1| 1455|Homo sapiens death-associated protei... 64 6e-10
AL160279-1|CAI16306.1| 1455|Homo sapiens death-associated protei... 64 6e-10
AL139393-2|CAI20815.1| 1498|Homo sapiens mitogen-activated prote... 64 6e-10
AL139393-1|CAI20816.1| 1544|Homo sapiens mitogen-activated prote... 64 6e-10
AL135935-1|CAH71126.1| 719|Homo sapiens p21(CDKN1A)-activated k... 64 6e-10
AL121914-4|CAM45838.1| 347|Homo sapiens aurora kinase A protein. 64 6e-10
AL121914-3|CAC12717.1| 403|Homo sapiens aurora kinase A protein. 64 6e-10
AL109942-4|CAI21477.1| 1498|Homo sapiens mitogen-activated prote... 64 6e-10
AL109942-3|CAC12766.2| 1544|Homo sapiens mitogen-activated prote... 64 6e-10
AL031652-1|CAI42211.1| 719|Homo sapiens p21(CDKN1A)-activated k... 64 6e-10
AF195947-1|AAF29508.1| 403|Homo sapiens STK15 serine/threonine ... 64 6e-10
AF011468-1|AAC63902.1| 403|Homo sapiens serine/threonine kinase... 64 6e-10
AF008551-1|AAC12708.1| 403|Homo sapiens aurora-related kinase 1... 64 6e-10
AB208871-1|BAD92108.1| 1433|Homo sapiens Hypothetical protein DK... 64 6e-10
AB040812-1|BAA94194.1| 719|Homo sapiens protein kinase PAK5 pro... 64 6e-10
AB033090-1|BAA86578.1| 753|Homo sapiens KIAA1264 protein protein. 64 6e-10
BC036023-1|AAH36023.1| 970|Homo sapiens polo-like kinase 4 (Dro... 63 7e-10
BC014243-1|AAH14243.1| 1187|Homo sapiens tyrosine kinase 2 protein. 63 7e-10
AY574904-1|AAT81413.1| 510|Homo sapiens regulated in COPD kinas... 63 7e-10
AY574902-1|AAT81411.1| 1215|Homo sapiens regulated in COPD kinas... 63 7e-10
AY574901-1|AAT81410.1| 1328|Homo sapiens regulated in COPD kinas... 63 7e-10
AB219242-1|BAE02826.1| 1141|Homo sapiens janus kinase 1 protein. 63 7e-10
AB047079-1|BAB21297.1| 925|Homo sapiens protein kinase/ribonucl... 63 7e-10
AB006972-1|BAB69958.1| 970|Homo sapiens Sak protein. 63 7e-10
U67156-1|AAC50894.1| 1374|Homo sapiens mitogen-activated kinase ... 63 1e-09
U35146-1|AAC50918.1| 493|Homo sapiens p56 KKIAMRE protein kinas... 63 1e-09
U07695-1|AAA20598.1| 987|Homo sapiens tyrosine kinase protein. 63 1e-09
U06454-1|AAA64745.1| 552|Homo sapiens AMP-activated protein kin... 63 1e-09
L40636-1|AAB08520.1| 984|Homo sapiens protein tyrosine kinase p... 63 1e-09
EF056019-1|ABK30810.1| 552|Homo sapiens AMP-activated alpha 2 s... 63 1e-09
D84476-1|BAA12684.2| 1374|Homo sapiens apoptosis signal-regulati... 63 1e-09
BC093981-1|AAH93981.1| 493|Homo sapiens cyclin-dependent kinase... 63 1e-09
BC093646-1|AAH93646.1| 493|Homo sapiens cyclin-dependent kinase... 63 1e-09
BC088829-1|AAH88829.1| 1374|Homo sapiens mitogen-activated prote... 63 1e-09
>BC127603-1|AAI27604.1| 829|Homo sapiens kinase suppressor of ras 2
protein.
Length = 829
Score = 235 bits (575), Expect = 1e-61
Identities = 113/201 (56%), Positives = 145/201 (72%), Gaps = 1/201 (0%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLC 181
WHG VA++L+ + D+ L FK EV +R+TRHEN+VLFMGACM PP LAI+TSLC
Sbjct: 564 WHGEVAIRLIDIE--RDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLC 621
Query: 182 KGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLESGKVVIT 361
KG TLY+ + K NK+ +AQ+I +GMGYLHA+GI+HKDLK+KN+F ++GKVVIT
Sbjct: 622 KGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVIT 681
Query: 362 DFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASL-LLPFSKATDIYAFG 538
DFGLFS++ + R D L I +GWLC+LAPEIIR L P LPFSK +D++A G
Sbjct: 682 DFGLFSISGVLQAGR-REDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALG 740
Query: 539 TVWYELLCGEFPFKGQPPESI 601
T+WYEL E+PFK QP E+I
Sbjct: 741 TIWYELHAREWPFKTQPAEAI 761
>BC107107-1|AAI07108.1| 827|Homo sapiens KSR2 protein protein.
Length = 827
Score = 235 bits (575), Expect = 1e-61
Identities = 113/201 (56%), Positives = 145/201 (72%), Gaps = 1/201 (0%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLC 181
WHG VA++L+ + D+ L FK EV +R+TRHEN+VLFMGACM PP LAI+TSLC
Sbjct: 562 WHGEVAIRLIDIE--RDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLC 619
Query: 182 KGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLESGKVVIT 361
KG TLY+ + K NK+ +AQ+I +GMGYLHA+GI+HKDLK+KN+F ++GKVVIT
Sbjct: 620 KGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVIT 679
Query: 362 DFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASL-LLPFSKATDIYAFG 538
DFGLFS++ + R D L I +GWLC+LAPEIIR L P LPFSK +D++A G
Sbjct: 680 DFGLFSISGVLQAGR-REDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALG 738
Query: 539 TVWYELLCGEFPFKGQPPESI 601
T+WYEL E+PFK QP E+I
Sbjct: 739 TIWYELHAREWPFKTQPAEAI 759
>BC107106-1|AAI07107.1| 827|Homo sapiens KSR2 protein protein.
Length = 827
Score = 235 bits (575), Expect = 1e-61
Identities = 113/201 (56%), Positives = 145/201 (72%), Gaps = 1/201 (0%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLC 181
WHG VA++L+ + D+ L FK EV +R+TRHEN+VLFMGACM PP LAI+TSLC
Sbjct: 562 WHGEVAIRLIDIE--RDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLC 619
Query: 182 KGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLESGKVVIT 361
KG TLY+ + K NK+ +AQ+I +GMGYLHA+GI+HKDLK+KN+F ++GKVVIT
Sbjct: 620 KGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVIT 679
Query: 362 DFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASL-LLPFSKATDIYAFG 538
DFGLFS++ + R D L I +GWLC+LAPEIIR L P LPFSK +D++A G
Sbjct: 680 DFGLFSISGVLQAGR-REDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALG 738
Query: 539 TVWYELLCGEFPFKGQPPESI 601
T+WYEL E+PFK QP E+I
Sbjct: 739 TIWYELHAREWPFKTQPAEAI 759
>AY345972-1|AAQ24226.1| 829|Homo sapiens kinase suppressor of Ras-2
protein.
Length = 829
Score = 235 bits (575), Expect = 1e-61
Identities = 113/201 (56%), Positives = 145/201 (72%), Gaps = 1/201 (0%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLC 181
WHG VA++L+ + D+ L FK EV +R+TRHEN+VLFMGACM PP LAI+TSLC
Sbjct: 564 WHGEVAIRLIDIE--RDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLC 621
Query: 182 KGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLESGKVVIT 361
KG TLY+ + K NK+ +AQ+I +GMGYLHA+GI+HKDLK+KN+F ++GKVVIT
Sbjct: 622 KGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVIT 681
Query: 362 DFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASL-LLPFSKATDIYAFG 538
DFGLFS++ + R D L I +GWLC+LAPEIIR L P LPFSK +D++A G
Sbjct: 682 DFGLFSISGVLQAGR-REDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALG 740
Query: 539 TVWYELLCGEFPFKGQPPESI 601
T+WYEL E+PFK QP E+I
Sbjct: 741 TIWYELHAREWPFKTQPAEAI 761
>U43586-1|AAC50354.1| 635|Homo sapiens KSR1 protein.
Length = 635
Score = 222 bits (543), Expect = 8e-58
Identities = 107/200 (53%), Positives = 139/200 (69%), Gaps = 1/200 (0%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLC 181
WHG VA++LL + + D L FK EV +R+TRHEN+VLFMGACM PP LAI+TS C
Sbjct: 368 WHGEVAIRLLEMDGHNQDH--LKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFC 425
Query: 182 KGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLESGKVVIT 361
KG TL++ + K NK+ +AQ+I +GMGYLHA+GI+HKDLK+KN+F ++GKVVIT
Sbjct: 426 KGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVIT 485
Query: 362 DFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASL-LLPFSKATDIYAFG 538
DFGLF ++ + R + L + WLCYLAPEI+R + P LPFSKA D+YAFG
Sbjct: 486 DFGLFGISGV-VREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFG 544
Query: 539 TVWYELLCGEFPFKGQPPES 598
TVWYEL ++P K Q E+
Sbjct: 545 TVWYELQARDWPLKNQAAEA 564
>M95712-1|AAA35609.2| 766|Homo sapiens B-raf protein protein.
Length = 766
Score = 157 bits (382), Expect = 2e-38
Identities = 89/193 (46%), Positives = 125/193 (64%), Gaps = 1/193 (0%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLC 181
WHG VAVK+L+V + L FK+EV + RKTRH N++LFMG KP +LAIVT C
Sbjct: 476 WHGDVAVKMLNVT--APTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKP-QLAIVTQWC 532
Query: 182 KGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL-ESGKVVI 358
+G +LY H+H+ + KF K + +A+Q +QGM YLHA+ IIH+DLK+ NIFL E V I
Sbjct: 533 EGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKI 592
Query: 359 TDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFG 538
DFGL +V G++ + + L SG + ++APE+IR + P+S +D+YAFG
Sbjct: 593 GDFGLATVKSRWSGSH-QFEQL---SGSILWMAPEVIRMQDKN-----PYSFQSDVYAFG 643
Query: 539 TVWYELLCGEFPF 577
V YEL+ G+ P+
Sbjct: 644 IVLYELMTGQLPY 656
>M21001-1|AAA96495.1| 328|Homo sapiens B-raf protein protein.
Length = 328
Score = 157 bits (382), Expect = 2e-38
Identities = 89/193 (46%), Positives = 125/193 (64%), Gaps = 1/193 (0%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLC 181
WHG VAVK+L+V + L FK+EV + RKTRH N++LFMG KP +LAIVT C
Sbjct: 38 WHGDVAVKMLNVT--APTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKP-QLAIVTQWC 94
Query: 182 KGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL-ESGKVVI 358
+G +LY H+H+ + KF K + +A+Q +QGM YLHA+ IIH+DLK+ NIFL E V I
Sbjct: 95 EGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKI 154
Query: 359 TDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFG 538
DFGL +V G++ + + L SG + ++APE+IR + P+S +D+YAFG
Sbjct: 155 GDFGLATVKSRWSGSH-QFEQL---SGSILWMAPEVIRMQDKN-----PYSFQSDVYAFG 205
Query: 539 TVWYELLCGEFPF 577
V YEL+ G+ P+
Sbjct: 206 IVLYELMTGQLPY 218
>BC112079-1|AAI12080.1| 766|Homo sapiens v-raf murine sarcoma viral
oncogene homolog B1 protein.
Length = 766
Score = 157 bits (382), Expect = 2e-38
Identities = 89/193 (46%), Positives = 125/193 (64%), Gaps = 1/193 (0%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLC 181
WHG VAVK+L+V + L FK+EV + RKTRH N++LFMG KP +LAIVT C
Sbjct: 476 WHGDVAVKMLNVT--APTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKP-QLAIVTQWC 532
Query: 182 KGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL-ESGKVVI 358
+G +LY H+H+ + KF K + +A+Q +QGM YLHA+ IIH+DLK+ NIFL E V I
Sbjct: 533 EGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKI 592
Query: 359 TDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFG 538
DFGL +V G++ + + L SG + ++APE+IR + P+S +D+YAFG
Sbjct: 593 GDFGLATVKSRWSGSH-QFEQL---SGSILWMAPEVIRMQDKN-----PYSFQSDVYAFG 643
Query: 539 TVWYELLCGEFPF 577
V YEL+ G+ P+
Sbjct: 644 IVLYELMTGQLPY 656
>BC101757-1|AAI01758.1| 766|Homo sapiens v-raf murine sarcoma viral
oncogene homolog B1 protein.
Length = 766
Score = 157 bits (382), Expect = 2e-38
Identities = 89/193 (46%), Positives = 125/193 (64%), Gaps = 1/193 (0%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLC 181
WHG VAVK+L+V + L FK+EV + RKTRH N++LFMG KP +LAIVT C
Sbjct: 476 WHGDVAVKMLNVT--APTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKP-QLAIVTQWC 532
Query: 182 KGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL-ESGKVVI 358
+G +LY H+H+ + KF K + +A+Q +QGM YLHA+ IIH+DLK+ NIFL E V I
Sbjct: 533 EGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKI 592
Query: 359 TDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFG 538
DFGL +V G++ + + L SG + ++APE+IR + P+S +D+YAFG
Sbjct: 593 GDFGLATVKSRWSGSH-QFEQL---SGSILWMAPEVIRMQDKN-----PYSFQSDVYAFG 643
Query: 539 TVWYELLCGEFPF 577
V YEL+ G+ P+
Sbjct: 644 IVLYELMTGQLPY 656
>AY803272-1|AAW30454.1| 1492|Homo sapiens AKAP9-BRAF fusion protein
protein.
Length = 1492
Score = 157 bits (382), Expect = 2e-38
Identities = 89/193 (46%), Positives = 125/193 (64%), Gaps = 1/193 (0%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLC 181
WHG VAVK+L+V + L FK+EV + RKTRH N++LFMG KP +LAIVT C
Sbjct: 1202 WHGDVAVKMLNVT--APTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKP-QLAIVTQWC 1258
Query: 182 KGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL-ESGKVVI 358
+G +LY H+H+ + KF K + +A+Q +QGM YLHA+ IIH+DLK+ NIFL E V I
Sbjct: 1259 EGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKI 1318
Query: 359 TDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFG 538
DFGL +V G++ + + L SG + ++APE+IR + P+S +D+YAFG
Sbjct: 1319 GDFGLATVKSRWSGSH-QFEQL---SGSILWMAPEVIRMQDKN-----PYSFQSDVYAFG 1369
Query: 539 TVWYELLCGEFPF 577
V YEL+ G+ P+
Sbjct: 1370 IVLYELMTGQLPY 1382
>AC006344-3|AAD43193.1| 651|Homo sapiens WUGSC:H_DJ0726N20.3
protein.
Length = 651
Score = 157 bits (382), Expect = 2e-38
Identities = 89/193 (46%), Positives = 125/193 (64%), Gaps = 1/193 (0%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLC 181
WHG VAVK+L+V + L FK+EV + RKTRH N++LFMG KP +LAIVT C
Sbjct: 361 WHGDVAVKMLNVT--APTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKP-QLAIVTQWC 417
Query: 182 KGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL-ESGKVVI 358
+G +LY H+H+ + KF K + +A+Q +QGM YLHA+ IIH+DLK+ NIFL E V I
Sbjct: 418 EGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKI 477
Query: 359 TDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFG 538
DFGL +V G++ + + L SG + ++APE+IR + P+S +D+YAFG
Sbjct: 478 GDFGLATVKSRWSGSH-QFEQL---SGSILWMAPEVIRMQDKN-----PYSFQSDVYAFG 528
Query: 539 TVWYELLCGEFPF 577
V YEL+ G+ P+
Sbjct: 529 IVLYELMTGQLPY 541
>X03484-1|CAA27204.1| 648|Homo sapiens protein ( Human mRNA for raf
oncogene. ).
Length = 648
Score = 154 bits (374), Expect = 2e-37
Identities = 83/193 (43%), Positives = 123/193 (63%), Gaps = 1/193 (0%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLC 181
WHG VAVK+L V+ + + F++EV++ RKTRH N++LFMG K LAIVT C
Sbjct: 368 WHGDVAVKILKVVDPTPEQ--FQAFRNEVAVLRKTRHVNILLFMGYMTKD-NLAIVTQWC 424
Query: 182 KGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLESGKVV-I 358
+G +LY H+H+++ KF + + +A+Q +QGM YLHA+ IIH+D+K+ NIFL G V I
Sbjct: 425 EGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKI 484
Query: 359 TDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFG 538
DFGL +V G+ + P+G + ++APE+IR + PFS +D+Y++G
Sbjct: 485 GDFGLATVKSRWSGS----QQVEQPTGSVLWMAPEVIRMQDNN-----PFSFQSDVYSYG 535
Query: 539 TVWYELLCGEFPF 577
V YEL+ GE P+
Sbjct: 536 IVLYELMTGELPY 548
>L00212-1|AAA60247.1| 421|Homo sapiens RAF1 protein.
Length = 421
Score = 154 bits (374), Expect = 2e-37
Identities = 83/193 (43%), Positives = 123/193 (63%), Gaps = 1/193 (0%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLC 181
WHG VAVK+L V+ + + F++EV++ RKTRH N++LFMG K LAIVT C
Sbjct: 141 WHGDVAVKILKVVDPTPEQ--FQAFRNEVAVLRKTRHVNILLFMGYMTKD-NLAIVTQWC 197
Query: 182 KGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLESGKVV-I 358
+G +LY H+H+++ KF + + +A+Q +QGM YLHA+ IIH+D+K+ NIFL G V I
Sbjct: 198 EGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKI 257
Query: 359 TDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFG 538
DFGL +V G+ + P+G + ++APE+IR + PFS +D+Y++G
Sbjct: 258 GDFGLATVKSRWSGS----QQVEQPTGSVLWMAPEVIRMQDNN-----PFSFQSDVYSYG 308
Query: 539 TVWYELLCGEFPF 577
V YEL+ GE P+
Sbjct: 309 IVLYELITGELPY 321
>BC018119-1|AAH18119.1| 648|Homo sapiens v-raf-1 murine leukemia
viral oncogene homolog 1 protein.
Length = 648
Score = 154 bits (374), Expect = 2e-37
Identities = 83/193 (43%), Positives = 123/193 (63%), Gaps = 1/193 (0%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLC 181
WHG VAVK+L V+ + + F++EV++ RKTRH N++LFMG K LAIVT C
Sbjct: 368 WHGDVAVKILKVVDPTPEQ--FQAFRNEVAVLRKTRHVNILLFMGYMTKD-NLAIVTQWC 424
Query: 182 KGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLESGKVV-I 358
+G +LY H+H+++ KF + + +A+Q +QGM YLHA+ IIH+D+K+ NIFL G V I
Sbjct: 425 EGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKI 484
Query: 359 TDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFG 538
DFGL +V G+ + P+G + ++APE+IR + PFS +D+Y++G
Sbjct: 485 GDFGLATVKSRWSGS----QQVEQPTGSVLWMAPEVIRMQDNN-----PFSFQSDVYSYG 535
Query: 539 TVWYELLCGEFPF 577
V YEL+ GE P+
Sbjct: 536 IVLYELMTGELPY 548
>AY271661-1|AAP03432.1| 648|Homo sapiens v-raf-1 murine leukemia
viral oncogene homolog 1 protein.
Length = 648
Score = 154 bits (374), Expect = 2e-37
Identities = 83/193 (43%), Positives = 123/193 (63%), Gaps = 1/193 (0%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLC 181
WHG VAVK+L V+ + + F++EV++ RKTRH N++LFMG K LAIVT C
Sbjct: 368 WHGDVAVKILKVVDPTPEQ--FQAFRNEVAVLRKTRHVNILLFMGYMTKD-NLAIVTQWC 424
Query: 182 KGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLESGKVV-I 358
+G +LY H+H+++ KF + + +A+Q +QGM YLHA+ IIH+D+K+ NIFL G V I
Sbjct: 425 EGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKI 484
Query: 359 TDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFG 538
DFGL +V G+ + P+G + ++APE+IR + PFS +D+Y++G
Sbjct: 485 GDFGLATVKSRWSGS----QQVEQPTGSVLWMAPEVIRMQDNN-----PFSFQSDVYSYG 535
Query: 539 TVWYELLCGEFPF 577
V YEL+ GE P+
Sbjct: 536 IVLYELMTGELPY 548
>Z84466-8|CAI42468.1| 606|Homo sapiens v-raf murine sarcoma 3611
viral oncogene homolog protein.
Length = 606
Score = 150 bits (364), Expect = 4e-36
Identities = 84/193 (43%), Positives = 118/193 (61%), Gaps = 1/193 (0%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLC 181
WHG VAVK+L V + + + FK+E+ + RKTRH N++LFMG M P AI+T C
Sbjct: 329 WHGDVAVKVLKVSQPTAEQA--QAFKNEMQVLRKTRHVNILLFMGF-MTRPGFAIITQWC 385
Query: 182 KGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLESGKVV-I 358
+G +LY H+H+ +F + + VA+Q +QGM YLHA+ IIH+DLK+ NIFL G V I
Sbjct: 386 EGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKI 445
Query: 359 TDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFG 538
DFGL +V G L PSG + ++A E+IR P+ P+S +D+YA+G
Sbjct: 446 GDFGLATVKTRWSG----AQPLEQPSGSVLWMAAEVIRMQDPN-----PYSFQSDVYAYG 496
Query: 539 TVWYELLCGEFPF 577
V YEL+ G P+
Sbjct: 497 VVLYELMTGSLPY 509
>X04790-1|CAA28476.1| 606|Homo sapiens protein ( Human mRNA for
A-raf-1 oncogene. ).
Length = 606
Score = 150 bits (364), Expect = 4e-36
Identities = 84/193 (43%), Positives = 118/193 (61%), Gaps = 1/193 (0%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLC 181
WHG VAVK+L V + + + FK+E+ + RKTRH N++LFMG M P AI+T C
Sbjct: 329 WHGDVAVKVLKVSQPTAEQA--QAFKNEMQVLRKTRHVNILLFMGF-MTRPGFAIITQWC 385
Query: 182 KGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLESGKVV-I 358
+G +LY H+H+ +F + + VA+Q +QGM YLHA+ IIH+DLK+ NIFL G V I
Sbjct: 386 EGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKI 445
Query: 359 TDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFG 538
DFGL +V G L PSG + ++A E+IR P+ P+S +D+YA+G
Sbjct: 446 GDFGLATVKTRWSG----AQPLEQPSGSVLWMAAEVIRMQDPN-----PYSFQSDVYAYG 496
Query: 539 TVWYELLCGEFPF 577
V YEL+ G P+
Sbjct: 497 VVLYELMTGSLPY 509
>U01337-1|AAB03517.1| 606|Homo sapiens Ser/Thr protein kinase
protein.
Length = 606
Score = 150 bits (364), Expect = 4e-36
Identities = 84/193 (43%), Positives = 118/193 (61%), Gaps = 1/193 (0%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLC 181
WHG VAVK+L V + + + FK+E+ + RKTRH N++LFMG M P AI+T C
Sbjct: 329 WHGDVAVKVLKVSQPTAEQA--QAFKNEMQVLRKTRHVNILLFMGF-MTRPGFAIITQWC 385
Query: 182 KGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLESGKVV-I 358
+G +LY H+H+ +F + + VA+Q +QGM YLHA+ IIH+DLK+ NIFL G V I
Sbjct: 386 EGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKI 445
Query: 359 TDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFG 538
DFGL +V G L PSG + ++A E+IR P+ P+S +D+YA+G
Sbjct: 446 GDFGLATVKTRWSG----AQPLEQPSGSVLWMAAEVIRMQDPN-----PYSFQSDVYAYG 496
Query: 539 TVWYELLCGEFPF 577
V YEL+ G P+
Sbjct: 497 VVLYELMTGSLPY 509
>L24038-1|AAA65219.1| 606|Homo sapiens ARAF1 protein.
Length = 606
Score = 150 bits (364), Expect = 4e-36
Identities = 84/193 (43%), Positives = 118/193 (61%), Gaps = 1/193 (0%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLC 181
WHG VAVK+L V + + + FK+E+ + RKTRH N++LFMG M P AI+T C
Sbjct: 329 WHGDVAVKVLKVSQPTAEQA--QAFKNEMQVLRKTRHVNILLFMGF-MTRPGFAIITQWC 385
Query: 182 KGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLESGKVV-I 358
+G +LY H+H+ +F + + VA+Q +QGM YLHA+ IIH+DLK+ NIFL G V I
Sbjct: 386 EGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKI 445
Query: 359 TDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFG 538
DFGL +V G L PSG + ++A E+IR P+ P+S +D+YA+G
Sbjct: 446 GDFGLATVKTRWSG----AQPLEQPSGSVLWMAAEVIRMQDPN-----PYSFQSDVYAYG 496
Query: 539 TVWYELLCGEFPF 577
V YEL+ G P+
Sbjct: 497 VVLYELMTGSLPY 509
>BT019864-1|AAV38667.1| 606|Homo sapiens v-raf murine sarcoma 3611
viral oncogene homolog 1 protein.
Length = 606
Score = 150 bits (364), Expect = 4e-36
Identities = 84/193 (43%), Positives = 118/193 (61%), Gaps = 1/193 (0%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLC 181
WHG VAVK+L V + + + FK+E+ + RKTRH N++LFMG M P AI+T C
Sbjct: 329 WHGDVAVKVLKVSQPTAEQA--QAFKNEMQVLRKTRHVNILLFMGF-MTRPGFAIITQWC 385
Query: 182 KGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLESGKVV-I 358
+G +LY H+H+ +F + + VA+Q +QGM YLHA+ IIH+DLK+ NIFL G V I
Sbjct: 386 EGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKI 445
Query: 359 TDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFG 538
DFGL +V G L PSG + ++A E+IR P+ P+S +D+YA+G
Sbjct: 446 GDFGLATVKTRWSG----AQPLEQPSGSVLWMAAEVIRMQDPN-----PYSFQSDVYAYG 496
Query: 539 TVWYELLCGEFPF 577
V YEL+ G P+
Sbjct: 497 VVLYELMTGSLPY 509
>BC007514-1|AAH07514.1| 609|Homo sapiens ARAF protein protein.
Length = 609
Score = 150 bits (364), Expect = 4e-36
Identities = 84/193 (43%), Positives = 118/193 (61%), Gaps = 1/193 (0%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLC 181
WHG VAVK+L V + + + FK+E+ + RKTRH N++LFMG M P AI+T C
Sbjct: 332 WHGDVAVKVLKVSQPTAEQA--QAFKNEMQVLRKTRHVNILLFMGF-MTRPGFAIITQWC 388
Query: 182 KGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLESGKVV-I 358
+G +LY H+H+ +F + + VA+Q +QGM YLHA+ IIH+DLK+ NIFL G V I
Sbjct: 389 EGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKI 448
Query: 359 TDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFG 538
DFGL +V G L PSG + ++A E+IR P+ P+S +D+YA+G
Sbjct: 449 GDFGLATVKTRWSG----AQPLEQPSGSVLWMAAEVIRMQDPN-----PYSFQSDVYAYG 499
Query: 539 TVWYELLCGEFPF 577
V YEL+ G P+
Sbjct: 500 VVLYELMTGSLPY 512
>BC002466-1|AAH02466.1| 606|Homo sapiens v-raf murine sarcoma 3611
viral oncogene homolog protein.
Length = 606
Score = 150 bits (364), Expect = 4e-36
Identities = 84/193 (43%), Positives = 118/193 (61%), Gaps = 1/193 (0%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLC 181
WHG VAVK+L V + + + FK+E+ + RKTRH N++LFMG M P AI+T C
Sbjct: 329 WHGDVAVKVLKVSQPTAEQA--QAFKNEMQVLRKTRHVNILLFMGF-MTRPGFAIITQWC 385
Query: 182 KGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLESGKVV-I 358
+G +LY H+H+ +F + + VA+Q +QGM YLHA+ IIH+DLK+ NIFL G V I
Sbjct: 386 EGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKI 445
Query: 359 TDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFG 538
DFGL +V G L PSG + ++A E+IR P+ P+S +D+YA+G
Sbjct: 446 GDFGLATVKTRWSG----AQPLEQPSGSVLWMAAEVIRMQDPN-----PYSFQSDVYAYG 496
Query: 539 TVWYELLCGEFPF 577
V YEL+ G P+
Sbjct: 497 VVLYELMTGSLPY 509
>M13829-1|AAB08754.1| 298|Homo sapiens raf related protein protein.
Length = 298
Score = 145 bits (352), Expect = 1e-34
Identities = 82/193 (42%), Positives = 117/193 (60%), Gaps = 1/193 (0%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLC 181
WHG VAVK+L V + + + FK+E+ + RKTRH N++ FMG M P +AI+T C
Sbjct: 38 WHGDVAVKVLKVSQPTAEQA--QAFKNEMQVLRKTRHVNILPFMGF-MTRPGVAIITQWC 94
Query: 182 KGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLESGKVV-I 358
+G +LY H+H+ +F + + VA+Q +QGM YLHA+ IIH+DLK+ NIFL G V I
Sbjct: 95 EGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKI 154
Query: 359 TDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFG 538
DFGL +V G L PSG + ++A E+ R P+ P+S +D+YA+G
Sbjct: 155 GDFGLATVKTRWSG----AQPLEQPSGPVLWMAAEVTRMQDPN-----PYSFQSDVYAYG 205
Query: 539 TVWYELLCGEFPF 577
V YEL+ G P+
Sbjct: 206 VVLYELMTGSLPY 218
>BC032787-1|AAH32787.1| 476|Homo sapiens
calcium/calmodulin-dependent protein kinase IG protein.
Length = 476
Score = 91.1 bits (216), Expect = 3e-18
Identities = 61/191 (31%), Positives = 95/191 (49%), Gaps = 4/191 (2%)
Frame = +2
Query: 17 AVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTL 196
A+K + P D SL ++E+++ +K +HEN+V +V L G L
Sbjct: 50 ALKCIKKSPAFRDSSL----ENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGEL 105
Query: 197 YTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL----ESGKVVITD 364
+ I L + +T + LV QQ+ + YLH GI+H+DLK +N+ E+ K++ITD
Sbjct: 106 FDRI-LERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITD 164
Query: 365 FGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTV 544
FGL + + N + G P Y+APE++ P+SKA D ++ G +
Sbjct: 165 FGLSKMEQ----NGIMSTACGTPG----YVAPEVLAQ--------KPYSKAVDCWSIGVI 208
Query: 545 WYELLCGEFPF 577
Y LLCG PF
Sbjct: 209 TYILLCGYPPF 219
>AY212935-1|AAP29964.1| 460|Homo sapiens CLICK III protein.
Length = 460
Score = 91.1 bits (216), Expect = 3e-18
Identities = 61/191 (31%), Positives = 95/191 (49%), Gaps = 4/191 (2%)
Frame = +2
Query: 17 AVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTL 196
A+K + P D SL ++E+++ +K +HEN+V +V L G L
Sbjct: 50 ALKCIKKSPAFRDSSL----ENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGEL 105
Query: 197 YTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL----ESGKVVITD 364
+ I L + +T + LV QQ+ + YLH GI+H+DLK +N+ E+ K++ITD
Sbjct: 106 FDRI-LERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITD 164
Query: 365 FGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTV 544
FGL + + N + G P Y+APE++ P+SKA D ++ G +
Sbjct: 165 FGLSKMEQ----NGIMSTACGTPG----YVAPEVLAQ--------KPYSKAVDCWSIGVI 208
Query: 545 WYELLCGEFPF 577
Y LLCG PF
Sbjct: 209 TYILLCGYPPF 219
>AL049688-1|CAB41259.1| 481|Homo sapiens hypothetical protein
protein.
Length = 481
Score = 91.1 bits (216), Expect = 3e-18
Identities = 61/191 (31%), Positives = 95/191 (49%), Gaps = 4/191 (2%)
Frame = +2
Query: 17 AVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTL 196
A+K + P D SL ++E+++ +K +HEN+V +V L G L
Sbjct: 55 ALKCIKKSPAFRDSSL----ENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGEL 110
Query: 197 YTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL----ESGKVVITD 364
+ I L + +T + LV QQ+ + YLH GI+H+DLK +N+ E+ K++ITD
Sbjct: 111 FDRI-LERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITD 169
Query: 365 FGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTV 544
FGL + + N + G P Y+APE++ P+SKA D ++ G +
Sbjct: 170 FGLSKMEQ----NGIMSTACGTPG----YVAPEVLAQ--------KPYSKAVDCWSIGVI 213
Query: 545 WYELLCGEFPF 577
Y LLCG PF
Sbjct: 214 TYILLCGYPPF 224
>AL023754-3|CAI19991.1| 476|Homo sapiens
calcium/calmodulin-dependent protein kinase IG protein.
Length = 476
Score = 91.1 bits (216), Expect = 3e-18
Identities = 61/191 (31%), Positives = 95/191 (49%), Gaps = 4/191 (2%)
Frame = +2
Query: 17 AVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTL 196
A+K + P D SL ++E+++ +K +HEN+V +V L G L
Sbjct: 50 ALKCIKKSPAFRDSSL----ENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGEL 105
Query: 197 YTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL----ESGKVVITD 364
+ I L + +T + LV QQ+ + YLH GI+H+DLK +N+ E+ K++ITD
Sbjct: 106 FDRI-LERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITD 164
Query: 365 FGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTV 544
FGL + + N + G P Y+APE++ P+SKA D ++ G +
Sbjct: 165 FGLSKMEQ----NGIMSTACGTPG----YVAPEVLAQ--------KPYSKAVDCWSIGVI 208
Query: 545 WYELLCGEFPF 577
Y LLCG PF
Sbjct: 209 TYILLCGYPPF 219
>AF428261-1|AAL28100.1| 476|Homo sapiens
calcium/calmodulin-dependent protein kinase I gamma
protein.
Length = 476
Score = 91.1 bits (216), Expect = 3e-18
Identities = 61/191 (31%), Positives = 95/191 (49%), Gaps = 4/191 (2%)
Frame = +2
Query: 17 AVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTL 196
A+K + P D SL ++E+++ +K +HEN+V +V L G L
Sbjct: 50 ALKCIKKSPAFRDSSL----ENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGEL 105
Query: 197 YTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL----ESGKVVITD 364
+ I L + +T + LV QQ+ + YLH GI+H+DLK +N+ E+ K++ITD
Sbjct: 106 FDRI-LERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITD 164
Query: 365 FGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTV 544
FGL + + N + G P Y+APE++ P+SKA D ++ G +
Sbjct: 165 FGLSKMEQ----NGIMSTACGTPG----YVAPEVLAQ--------KPYSKAVDCWSIGVI 208
Query: 545 WYELLCGEFPF 577
Y LLCG PF
Sbjct: 209 TYILLCGYPPF 219
>BC035745-1|AAH35745.1| 385|Homo sapiens
calcium/calmodulin-dependent protein kinase ID protein.
Length = 385
Score = 89.0 bits (211), Expect = 1e-17
Identities = 54/173 (31%), Positives = 88/173 (50%), Gaps = 4/173 (2%)
Frame = +2
Query: 71 TFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVL 250
+ ++E+++ RK +HEN+V P L +V L G L+ I + K +T +
Sbjct: 65 SIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRI-VEKGFYTEKDAST 123
Query: 251 VAQQISQGMGYLHARGIIHKDLKTKNIFL----ESGKVVITDFGLFSVTKLCFGNNARGD 418
+ +Q+ + YLH GI+H+DLK +N+ E K++I+DFGL + +GD
Sbjct: 124 LIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM-------EGKGD 176
Query: 419 SLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
+ G Y+APE++ P+SKA D ++ G + Y LLCG PF
Sbjct: 177 VMSTACGTPGYVAPEVLAQ--------KPYSKAVDCWSIGVIAYILLCGYPPF 221
>AL731559-2|CAI14675.1| 385|Homo sapiens
calcium/calmodulin-dependent protein kinase ID protein.
Length = 385
Score = 89.0 bits (211), Expect = 1e-17
Identities = 54/173 (31%), Positives = 88/173 (50%), Gaps = 4/173 (2%)
Frame = +2
Query: 71 TFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVL 250
+ ++E+++ RK +HEN+V P L +V L G L+ I + K +T +
Sbjct: 65 SIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRI-VEKGFYTEKDAST 123
Query: 251 VAQQISQGMGYLHARGIIHKDLKTKNIFL----ESGKVVITDFGLFSVTKLCFGNNARGD 418
+ +Q+ + YLH GI+H+DLK +N+ E K++I+DFGL + +GD
Sbjct: 124 LIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM-------EGKGD 176
Query: 419 SLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
+ G Y+APE++ P+SKA D ++ G + Y LLCG PF
Sbjct: 177 VMSTACGTPGYVAPEVLAQ--------KPYSKAVDCWSIGVIAYILLCGYPPF 221
>AL731559-1|CAI14674.1| 357|Homo sapiens
calcium/calmodulin-dependent protein kinase ID protein.
Length = 357
Score = 89.0 bits (211), Expect = 1e-17
Identities = 54/173 (31%), Positives = 88/173 (50%), Gaps = 4/173 (2%)
Frame = +2
Query: 71 TFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVL 250
+ ++E+++ RK +HEN+V P L +V L G L+ I + K +T +
Sbjct: 65 SIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRI-VEKGFYTEKDAST 123
Query: 251 VAQQISQGMGYLHARGIIHKDLKTKNIFL----ESGKVVITDFGLFSVTKLCFGNNARGD 418
+ +Q+ + YLH GI+H+DLK +N+ E K++I+DFGL + +GD
Sbjct: 124 LIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM-------EGKGD 176
Query: 419 SLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
+ G Y+APE++ P+SKA D ++ G + Y LLCG PF
Sbjct: 177 VMSTACGTPGYVAPEVLAQ--------KPYSKAVDCWSIGVIAYILLCGYPPF 221
>AL512783-2|CAH74036.1| 385|Homo sapiens
calcium/calmodulin-dependent protein kinase ID protein.
Length = 385
Score = 89.0 bits (211), Expect = 1e-17
Identities = 54/173 (31%), Positives = 88/173 (50%), Gaps = 4/173 (2%)
Frame = +2
Query: 71 TFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVL 250
+ ++E+++ RK +HEN+V P L +V L G L+ I + K +T +
Sbjct: 65 SIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRI-VEKGFYTEKDAST 123
Query: 251 VAQQISQGMGYLHARGIIHKDLKTKNIFL----ESGKVVITDFGLFSVTKLCFGNNARGD 418
+ +Q+ + YLH GI+H+DLK +N+ E K++I+DFGL + +GD
Sbjct: 124 LIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM-------EGKGD 176
Query: 419 SLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
+ G Y+APE++ P+SKA D ++ G + Y LLCG PF
Sbjct: 177 VMSTACGTPGYVAPEVLAQ--------KPYSKAVDCWSIGVIAYILLCGYPPF 221
>AL512783-1|CAH74035.1| 357|Homo sapiens
calcium/calmodulin-dependent protein kinase ID protein.
Length = 357
Score = 89.0 bits (211), Expect = 1e-17
Identities = 54/173 (31%), Positives = 88/173 (50%), Gaps = 4/173 (2%)
Frame = +2
Query: 71 TFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVL 250
+ ++E+++ RK +HEN+V P L +V L G L+ I + K +T +
Sbjct: 65 SIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRI-VEKGFYTEKDAST 123
Query: 251 VAQQISQGMGYLHARGIIHKDLKTKNIFL----ESGKVVITDFGLFSVTKLCFGNNARGD 418
+ +Q+ + YLH GI+H+DLK +N+ E K++I+DFGL + +GD
Sbjct: 124 LIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM-------EGKGD 176
Query: 419 SLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
+ G Y+APE++ P+SKA D ++ G + Y LLCG PF
Sbjct: 177 VMSTACGTPGYVAPEVLAQ--------KPYSKAVDCWSIGVIAYILLCGYPPF 221
>AL512284-2|CAH71694.1| 385|Homo sapiens
calcium/calmodulin-dependent protein kinase ID protein.
Length = 385
Score = 89.0 bits (211), Expect = 1e-17
Identities = 54/173 (31%), Positives = 88/173 (50%), Gaps = 4/173 (2%)
Frame = +2
Query: 71 TFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVL 250
+ ++E+++ RK +HEN+V P L +V L G L+ I + K +T +
Sbjct: 65 SIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRI-VEKGFYTEKDAST 123
Query: 251 VAQQISQGMGYLHARGIIHKDLKTKNIFL----ESGKVVITDFGLFSVTKLCFGNNARGD 418
+ +Q+ + YLH GI+H+DLK +N+ E K++I+DFGL + +GD
Sbjct: 124 LIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM-------EGKGD 176
Query: 419 SLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
+ G Y+APE++ P+SKA D ++ G + Y LLCG PF
Sbjct: 177 VMSTACGTPGYVAPEVLAQ--------KPYSKAVDCWSIGVIAYILLCGYPPF 221
>AL512284-1|CAH71693.1| 357|Homo sapiens
calcium/calmodulin-dependent protein kinase ID protein.
Length = 357
Score = 89.0 bits (211), Expect = 1e-17
Identities = 54/173 (31%), Positives = 88/173 (50%), Gaps = 4/173 (2%)
Frame = +2
Query: 71 TFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVL 250
+ ++E+++ RK +HEN+V P L +V L G L+ I + K +T +
Sbjct: 65 SIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRI-VEKGFYTEKDAST 123
Query: 251 VAQQISQGMGYLHARGIIHKDLKTKNIFL----ESGKVVITDFGLFSVTKLCFGNNARGD 418
+ +Q+ + YLH GI+H+DLK +N+ E K++I+DFGL + +GD
Sbjct: 124 LIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM-------EGKGD 176
Query: 419 SLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
+ G Y+APE++ P+SKA D ++ G + Y LLCG PF
Sbjct: 177 VMSTACGTPGYVAPEVLAQ--------KPYSKAVDCWSIGVIAYILLCGYPPF 221
>AL391314-2|CAI14410.1| 385|Homo sapiens
calcium/calmodulin-dependent protein kinase ID protein.
Length = 385
Score = 89.0 bits (211), Expect = 1e-17
Identities = 54/173 (31%), Positives = 88/173 (50%), Gaps = 4/173 (2%)
Frame = +2
Query: 71 TFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVL 250
+ ++E+++ RK +HEN+V P L +V L G L+ I + K +T +
Sbjct: 65 SIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRI-VEKGFYTEKDAST 123
Query: 251 VAQQISQGMGYLHARGIIHKDLKTKNIFL----ESGKVVITDFGLFSVTKLCFGNNARGD 418
+ +Q+ + YLH GI+H+DLK +N+ E K++I+DFGL + +GD
Sbjct: 124 LIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM-------EGKGD 176
Query: 419 SLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
+ G Y+APE++ P+SKA D ++ G + Y LLCG PF
Sbjct: 177 VMSTACGTPGYVAPEVLAQ--------KPYSKAVDCWSIGVIAYILLCGYPPF 221
>AL391314-1|CAI14409.1| 357|Homo sapiens
calcium/calmodulin-dependent protein kinase ID protein.
Length = 357
Score = 89.0 bits (211), Expect = 1e-17
Identities = 54/173 (31%), Positives = 88/173 (50%), Gaps = 4/173 (2%)
Frame = +2
Query: 71 TFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVL 250
+ ++E+++ RK +HEN+V P L +V L G L+ I + K +T +
Sbjct: 65 SIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRI-VEKGFYTEKDAST 123
Query: 251 VAQQISQGMGYLHARGIIHKDLKTKNIFL----ESGKVVITDFGLFSVTKLCFGNNARGD 418
+ +Q+ + YLH GI+H+DLK +N+ E K++I+DFGL + +GD
Sbjct: 124 LIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM-------EGKGD 176
Query: 419 SLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
+ G Y+APE++ P+SKA D ++ G + Y LLCG PF
Sbjct: 177 VMSTACGTPGYVAPEVLAQ--------KPYSKAVDCWSIGVIAYILLCGYPPF 221
>AF286366-1|AAG00534.1| 357|Homo sapiens CamKI-like protein kinase
protein.
Length = 357
Score = 89.0 bits (211), Expect = 1e-17
Identities = 54/173 (31%), Positives = 88/173 (50%), Gaps = 4/173 (2%)
Frame = +2
Query: 71 TFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVL 250
+ ++E+++ RK +HEN+V P L +V L G L+ I + K +T +
Sbjct: 65 SIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRI-VEKGFYTEKDAST 123
Query: 251 VAQQISQGMGYLHARGIIHKDLKTKNIFL----ESGKVVITDFGLFSVTKLCFGNNARGD 418
+ +Q+ + YLH GI+H+DLK +N+ E K++I+DFGL + +GD
Sbjct: 124 LIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM-------EGKGD 176
Query: 419 SLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
+ G Y+APE++ P+SKA D ++ G + Y LLCG PF
Sbjct: 177 VMSTACGTPGYVAPEVLAQ--------KPYSKAVDCWSIGVIAYILLCGYPPF 221
>AB081726-1|BAC19846.1| 385|Homo sapiens CaM-kinase I delta
protein.
Length = 385
Score = 89.0 bits (211), Expect = 1e-17
Identities = 54/173 (31%), Positives = 88/173 (50%), Gaps = 4/173 (2%)
Frame = +2
Query: 71 TFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVL 250
+ ++E+++ RK +HEN+V P L +V L G L+ I + K +T +
Sbjct: 65 SIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRI-VEKGFYTEKDAST 123
Query: 251 VAQQISQGMGYLHARGIIHKDLKTKNIFL----ESGKVVITDFGLFSVTKLCFGNNARGD 418
+ +Q+ + YLH GI+H+DLK +N+ E K++I+DFGL + +GD
Sbjct: 124 LIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM-------EGKGD 176
Query: 419 SLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
+ G Y+APE++ P+SKA D ++ G + Y LLCG PF
Sbjct: 177 VMSTACGTPGYVAPEVLAQ--------KPYSKAVDCWSIGVIAYILLCGYPPF 221
>BC133706-1|AAI33707.1| 1104|Homo sapiens MAP3K9 protein protein.
Length = 1104
Score = 87.8 bits (208), Expect = 3e-17
Identities = 62/200 (31%), Positives = 95/200 (47%), Gaps = 6/200 (3%)
Frame = +2
Query: 2 WHG-AVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSL 178
W G VAVK P D ++ + E +F +H N++ G C+K P L +V
Sbjct: 163 WIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEF 222
Query: 179 CKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARG---IIHKDLKTKNIFLESGK 349
+G L + L + + V A QI++GM YLH IIH+DLK+ NI + K
Sbjct: 223 ARGGPL--NRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQ-K 279
Query: 350 VVITDFG--LFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATD 523
V D + +T + +G ++APE+IRA FSK +D
Sbjct: 280 VENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASM--------FSKGSD 331
Query: 524 IYAFGTVWYELLCGEFPFKG 583
++++G + +ELL GE PF+G
Sbjct: 332 VWSYGVLLWELLTGEVPFRG 351
>BC111407-1|AAI11408.1| 1103|Homo sapiens MAP3K9 protein protein.
Length = 1103
Score = 87.8 bits (208), Expect = 3e-17
Identities = 62/200 (31%), Positives = 95/200 (47%), Gaps = 6/200 (3%)
Frame = +2
Query: 2 WHG-AVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSL 178
W G VAVK P D ++ + E +F +H N++ G C+K P L +V
Sbjct: 162 WIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEF 221
Query: 179 CKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARG---IIHKDLKTKNIFLESGK 349
+G L + L + + V A QI++GM YLH IIH+DLK+ NI + K
Sbjct: 222 ARGGPL--NRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQ-K 278
Query: 350 VVITDFG--LFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATD 523
V D + +T + +G ++APE+IRA FSK +D
Sbjct: 279 VENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASM--------FSKGSD 330
Query: 524 IYAFGTVWYELLCGEFPFKG 583
++++G + +ELL GE PF+G
Sbjct: 331 VWSYGVLLWELLTGEVPFRG 350
>AY327900-1|AAQ23054.1| 1104|Homo sapiens mixed-lineage protein
kinase 1 protein.
Length = 1104
Score = 87.8 bits (208), Expect = 3e-17
Identities = 62/200 (31%), Positives = 95/200 (47%), Gaps = 6/200 (3%)
Frame = +2
Query: 2 WHG-AVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSL 178
W G VAVK P D ++ + E +F +H N++ G C+K P L +V
Sbjct: 163 WIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEF 222
Query: 179 CKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARG---IIHKDLKTKNIFLESGK 349
+G L + L + + V A QI++GM YLH IIH+DLK+ NI + K
Sbjct: 223 ARGGPL--NRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQ-K 279
Query: 350 VVITDFG--LFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATD 523
V D + +T + +G ++APE+IRA FSK +D
Sbjct: 280 VENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASM--------FSKGSD 331
Query: 524 IYAFGTVWYELLCGEFPFKG 583
++++G + +ELL GE PF+G
Sbjct: 332 VWSYGVLLWELLTGEVPFRG 351
>AF251442-1|AAG44591.1| 1066|Homo sapiens mixed lineage kinase MLK1
protein.
Length = 1066
Score = 87.8 bits (208), Expect = 3e-17
Identities = 62/200 (31%), Positives = 95/200 (47%), Gaps = 6/200 (3%)
Frame = +2
Query: 2 WHG-AVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSL 178
W G VAVK P D ++ + E +F +H N++ G C+K P L +V
Sbjct: 111 WIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEF 170
Query: 179 CKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARG---IIHKDLKTKNIFLESGK 349
+G L + L + + V A QI++GM YLH IIH+DLK+ NI + K
Sbjct: 171 ARGGPL--NRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQ-K 227
Query: 350 VVITDFG--LFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATD 523
V D + +T + +G ++APE+IRA FSK +D
Sbjct: 228 VENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASM--------FSKGSD 279
Query: 524 IYAFGTVWYELLCGEFPFKG 583
++++G + +ELL GE PF+G
Sbjct: 280 VWSYGVLLWELLTGEVPFRG 299
>BC032865-1|AAH32865.1| 843|Homo sapiens TNNI3K protein protein.
Length = 843
Score = 85.4 bits (202), Expect = 2e-16
Identities = 55/180 (30%), Positives = 93/180 (51%), Gaps = 4/180 (2%)
Frame = +2
Query: 65 LDTFKHEVSIFRKTRHENLVLFMGACMKPP-RLAIVTSLCKGMTLYTHIHLRKDKFTANK 241
+D F EVSI + H ++ F+GAC+ P + AIVT G +L++ +H +K
Sbjct: 604 VDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQS 663
Query: 242 SVLVAQQISQGMGYLH--ARGIIHKDLKTKNIFL-ESGKVVITDFGLFSVTKLCFGNNAR 412
+++A +++GM YLH + IIH+DL + NI L E G V+ DFG + F +
Sbjct: 664 KLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFG-----ESRFLQSLD 718
Query: 413 GDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPP 592
D++ G L ++APE+ + ++ D++++ +E+L GE PF P
Sbjct: 719 EDNMTKQPGNLLWMAPEVF-------TQCTRYTIKADVFSYALCLWEILTGEIPFAHLKP 771
>DQ822519-1|ABG46944.1| 835|Homo sapiens TNNI3 interacting kinase
protein.
Length = 835
Score = 84.6 bits (200), Expect = 3e-16
Identities = 55/180 (30%), Positives = 93/180 (51%), Gaps = 4/180 (2%)
Frame = +2
Query: 65 LDTFKHEVSIFRKTRHENLVLFMGACMKPP-RLAIVTSLCKGMTLYTHIHLRKDKFTANK 241
+D F EVSI + H ++ F+GAC+ P + AIVT G +L++ +H +K
Sbjct: 503 VDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQS 562
Query: 242 SVLVAQQISQGMGYLH--ARGIIHKDLKTKNIFL-ESGKVVITDFGLFSVTKLCFGNNAR 412
+++A +++GM YLH + IIH+DL + NI L E G V+ DFG + F +
Sbjct: 563 KLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFG-----ESRFLQSLD 617
Query: 413 GDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPP 592
D++ G L ++APE+ + ++ D++++ +E+L GE PF P
Sbjct: 618 EDNMTKQPGNLRWMAPEVF-------TQCTRYTIKADVFSYALCLWEILTGEIPFAHLKP 670
>BX470253-1|CAI16293.1| 835|Homo sapiens TNNI3 interacting kinase
protein.
Length = 835
Score = 84.6 bits (200), Expect = 3e-16
Identities = 55/180 (30%), Positives = 93/180 (51%), Gaps = 4/180 (2%)
Frame = +2
Query: 65 LDTFKHEVSIFRKTRHENLVLFMGACMKPP-RLAIVTSLCKGMTLYTHIHLRKDKFTANK 241
+D F EVSI + H ++ F+GAC+ P + AIVT G +L++ +H +K
Sbjct: 503 VDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQS 562
Query: 242 SVLVAQQISQGMGYLH--ARGIIHKDLKTKNIFL-ESGKVVITDFGLFSVTKLCFGNNAR 412
+++A +++GM YLH + IIH+DL + NI L E G V+ DFG + F +
Sbjct: 563 KLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFG-----ESRFLQSLD 617
Query: 413 GDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPP 592
D++ G L ++APE+ + ++ D++++ +E+L GE PF P
Sbjct: 618 EDNMTKQPGNLRWMAPEVF-------TQCTRYTIKADVFSYALCLWEILTGEIPFAHLKP 670
>BC117262-1|AAI17263.1| 835|Homo sapiens TNNI3 interacting kinase
protein.
Length = 835
Score = 84.6 bits (200), Expect = 3e-16
Identities = 55/180 (30%), Positives = 93/180 (51%), Gaps = 4/180 (2%)
Frame = +2
Query: 65 LDTFKHEVSIFRKTRHENLVLFMGACMKPP-RLAIVTSLCKGMTLYTHIHLRKDKFTANK 241
+D F EVSI + H ++ F+GAC+ P + AIVT G +L++ +H +K
Sbjct: 503 VDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQS 562
Query: 242 SVLVAQQISQGMGYLH--ARGIIHKDLKTKNIFL-ESGKVVITDFGLFSVTKLCFGNNAR 412
+++A +++GM YLH + IIH+DL + NI L E G V+ DFG + F +
Sbjct: 563 KLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFG-----ESRFLQSLD 617
Query: 413 GDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPP 592
D++ G L ++APE+ + ++ D++++ +E+L GE PF P
Sbjct: 618 EDNMTKQPGNLRWMAPEVF-------TQCTRYTIKADVFSYALCLWEILTGEIPFAHLKP 670
>BC113539-1|AAI13540.1| 835|Homo sapiens TNNI3 interacting kinase
protein.
Length = 835
Score = 84.6 bits (200), Expect = 3e-16
Identities = 55/180 (30%), Positives = 93/180 (51%), Gaps = 4/180 (2%)
Frame = +2
Query: 65 LDTFKHEVSIFRKTRHENLVLFMGACMKPP-RLAIVTSLCKGMTLYTHIHLRKDKFTANK 241
+D F EVSI + H ++ F+GAC+ P + AIVT G +L++ +H +K
Sbjct: 503 VDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQS 562
Query: 242 SVLVAQQISQGMGYLH--ARGIIHKDLKTKNIFL-ESGKVVITDFGLFSVTKLCFGNNAR 412
+++A +++GM YLH + IIH+DL + NI L E G V+ DFG + F +
Sbjct: 563 KLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFG-----ESRFLQSLD 617
Query: 413 GDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPP 592
D++ G L ++APE+ + ++ D++++ +E+L GE PF P
Sbjct: 618 EDNMTKQPGNLRWMAPEVF-------TQCTRYTIKADVFSYALCLWEILTGEIPFAHLKP 670
>AY303691-1|AAP72030.1| 835|Homo sapiens cardiac ankyrin repeat
kinase protein.
Length = 835
Score = 84.6 bits (200), Expect = 3e-16
Identities = 55/180 (30%), Positives = 93/180 (51%), Gaps = 4/180 (2%)
Frame = +2
Query: 65 LDTFKHEVSIFRKTRHENLVLFMGACMKPP-RLAIVTSLCKGMTLYTHIHLRKDKFTANK 241
+D F EVSI + H ++ F+GAC+ P + AIVT G +L++ +H +K
Sbjct: 503 VDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQS 562
Query: 242 SVLVAQQISQGMGYLH--ARGIIHKDLKTKNIFL-ESGKVVITDFGLFSVTKLCFGNNAR 412
+++A +++GM YLH + IIH+DL + NI L E G V+ DFG + F +
Sbjct: 563 KLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFG-----ESRFLQSLD 617
Query: 413 GDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPP 592
D++ G L ++APE+ + ++ D++++ +E+L GE PF P
Sbjct: 618 EDNMTKQPGNLRWMAPEVF-------TQCTRYTIKADVFSYALCLWEILTGEIPFAHLKP 670
>AF116826-1|AAD29632.1| 835|Homo sapiens putative protein-tyrosine
kinase protein.
Length = 835
Score = 84.6 bits (200), Expect = 3e-16
Identities = 55/180 (30%), Positives = 93/180 (51%), Gaps = 4/180 (2%)
Frame = +2
Query: 65 LDTFKHEVSIFRKTRHENLVLFMGACMKPP-RLAIVTSLCKGMTLYTHIHLRKDKFTANK 241
+D F EVSI + H ++ F+GAC+ P + AIVT G +L++ +H +K
Sbjct: 503 VDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQS 562
Query: 242 SVLVAQQISQGMGYLH--ARGIIHKDLKTKNIFL-ESGKVVITDFGLFSVTKLCFGNNAR 412
+++A +++GM YLH + IIH+DL + NI L E G V+ DFG + F +
Sbjct: 563 KLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFG-----ESRFLQSLD 617
Query: 413 GDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPP 592
D++ G L ++APE+ + ++ D++++ +E+L GE PF P
Sbjct: 618 EDNMTKQPGNLRWMAPEVF-------TQCTRYTIKADVFSYALCLWEILTGEIPFAHLKP 670
>AB208941-1|BAD92178.1| 941|Homo sapiens TNNI3 interacting kinase
variant protein.
Length = 941
Score = 84.6 bits (200), Expect = 3e-16
Identities = 55/180 (30%), Positives = 93/180 (51%), Gaps = 4/180 (2%)
Frame = +2
Query: 65 LDTFKHEVSIFRKTRHENLVLFMGACMKPP-RLAIVTSLCKGMTLYTHIHLRKDKFTANK 241
+D F EVSI + H ++ F+GAC+ P + AIVT G +L++ +H +K
Sbjct: 609 VDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQS 668
Query: 242 SVLVAQQISQGMGYLH--ARGIIHKDLKTKNIFL-ESGKVVITDFGLFSVTKLCFGNNAR 412
+++A +++GM YLH + IIH+DL + NI L E G V+ DFG + F +
Sbjct: 669 KLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFG-----ESRFLQSLD 723
Query: 413 GDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPP 592
D++ G L ++APE+ + ++ D++++ +E+L GE PF P
Sbjct: 724 EDNMTKQPGNLRWMAPEVF-------TQCTRYTIKADVFSYALCLWEILTGEIPFAHLKP 776
>AB001872-1|BAA24817.1| 966|Homo sapiens leucine zipper bearing
kinase protein.
Length = 966
Score = 83.0 bits (196), Expect = 8e-16
Identities = 55/167 (32%), Positives = 84/167 (50%), Gaps = 1/167 (0%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
++ RK +H N++ F G C + P I+ C LY + + K T V +
Sbjct: 204 DIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGR-KITPRLLVDWSTG 262
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFL-ESGKVVITDFGLFSVTKLCFGNNARGDSLGIPSG 439
I+ GM YLH IIH+DLK+ N+ + + V I+DFG T + + S +G
Sbjct: 263 IASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFG----TSKELSDKSTKMSF---AG 315
Query: 440 WLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFK 580
+ ++APE+IR P S+ DI++FG V +ELL GE P+K
Sbjct: 316 TVAWMAPEVIRNE--------PVSEKVDIWSFGVVLWELLTGEIPYK 354
>BC062616-1|AAH62616.1| 424|Homo sapiens protein serine kinase H1
protein.
Length = 424
Score = 82.6 bits (195), Expect = 1e-15
Identities = 54/171 (31%), Positives = 86/171 (50%), Gaps = 5/171 (2%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E+ + R+ RH N++ + R+ +V L G L+ I + K FT + V Q
Sbjct: 143 ELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRI-IAKGSFTERDATRVLQM 201
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFL----ESGKVVITDFGLFSVTKLCFGNNA-RGDSLG 427
+ G+ YLHA GI H+DLK +N+ K++ITDFGL S K G++ + G
Sbjct: 202 VLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKK--GDDCLMKTTCG 259
Query: 428 IPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFK 580
P Y+APE++ + P++ + D++A G + Y LL G PF+
Sbjct: 260 TPE----YIAPEVL--------VRKPYTNSVDMWALGVIAYILLSGTMPFE 298
>AJ272212-1|CAB91984.1| 424|Homo sapiens protein serine kinase
protein.
Length = 424
Score = 82.6 bits (195), Expect = 1e-15
Identities = 54/171 (31%), Positives = 86/171 (50%), Gaps = 5/171 (2%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E+ + R+ RH N++ + R+ +V L G L+ I + K FT + V Q
Sbjct: 143 ELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRI-IAKGSFTERDATRVLQM 201
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFL----ESGKVVITDFGLFSVTKLCFGNNA-RGDSLG 427
+ G+ YLHA GI H+DLK +N+ K++ITDFGL S K G++ + G
Sbjct: 202 VLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKK--GDDCLMKTTCG 259
Query: 428 IPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFK 580
P Y+APE++ + P++ + D++A G + Y LL G PF+
Sbjct: 260 TPE----YIAPEVL--------VRKPYTNSVDMWALGVIAYILLSGTMPFE 298
>Z48615-1|CAA88531.1| 953|Homo sapiens serine/threonine kinase with
SH3 domain, leucine zipper domain and proline rich
protein.
Length = 953
Score = 81.8 bits (193), Expect = 2e-15
Identities = 60/198 (30%), Positives = 95/198 (47%), Gaps = 5/198 (2%)
Frame = +2
Query: 2 WHGA-VAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSL 178
W G VAVK + P D + E +F +H N++ GAC+ PP L +V
Sbjct: 117 WRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEY 176
Query: 179 CKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARG---IIHKDLKTKNI-FLESG 346
+G L + R + + V A Q+++GM YLH IIH+DLK+ NI LE+
Sbjct: 177 ARGGALSRVLAGR--RVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAI 234
Query: 347 KVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDI 526
+ + +T + +G ++APE+IR L FSK++D+
Sbjct: 235 ENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIR--------LSLFSKSSDV 286
Query: 527 YAFGTVWYELLCGEFPFK 580
++FG + +ELL GE P++
Sbjct: 287 WSFGVLLWELLTGEVPYR 304
>X90846-1|CAA62351.1| 954|Homo sapiens mixed lineage kinase 2
protein.
Length = 954
Score = 81.8 bits (193), Expect = 2e-15
Identities = 60/198 (30%), Positives = 95/198 (47%), Gaps = 5/198 (2%)
Frame = +2
Query: 2 WHGA-VAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSL 178
W G VAVK + P D + E +F +H N++ GAC+ PP L +V
Sbjct: 117 WRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEY 176
Query: 179 CKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARG---IIHKDLKTKNI-FLESG 346
+G L + R + + V A Q+++GM YLH IIH+DLK+ NI LE+
Sbjct: 177 ARGGALSRVLAGR--RVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAI 234
Query: 347 KVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDI 526
+ + +T + +G ++APE+IR L FSK++D+
Sbjct: 235 ENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIR--------LSLFSKSSDV 286
Query: 527 YAFGTVWYELLCGEFPFK 580
++FG + +ELL GE P++
Sbjct: 287 WSFGVLLWELLTGEVPYR 304
>U07358-1|AAA67343.1| 859|Homo sapiens serine/threonine protein
kinase protein.
Length = 859
Score = 80.6 bits (190), Expect = 5e-15
Identities = 56/172 (32%), Positives = 86/172 (50%), Gaps = 1/172 (0%)
Frame = +2
Query: 68 DTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSV 247
D + ++ RK +H N++ F G C + P I+ C LY + + T + V
Sbjct: 156 DLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRP-VTPSLLV 214
Query: 248 LVAQQISQGMGYLHARGIIHKDLKTKNIFLESGKVV-ITDFGLFSVTKLCFGNNARGDSL 424
+ I+ GM YLH IIH+DLK+ N+ + VV I+DFG T + + S
Sbjct: 215 DWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFG----TSKELSDKSTKMSF 270
Query: 425 GIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFK 580
+G + ++APE+IR P S+ DI++FG V +ELL GE P+K
Sbjct: 271 ---AGTVAWMAPEVIRNE--------PVSEKVDIWSFGVVLWELLTGEIPYK 311
>BC050050-1|AAH50050.1| 567|Homo sapiens MAP3K12 protein protein.
Length = 567
Score = 80.6 bits (190), Expect = 5e-15
Identities = 56/172 (32%), Positives = 86/172 (50%), Gaps = 1/172 (0%)
Frame = +2
Query: 68 DTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSV 247
D + ++ RK +H N++ F G C + P I+ C LY + + T + V
Sbjct: 189 DLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRP-VTPSLLV 247
Query: 248 LVAQQISQGMGYLHARGIIHKDLKTKNIFLESGKVV-ITDFGLFSVTKLCFGNNARGDSL 424
+ I+ GM YLH IIH+DLK+ N+ + VV I+DFG T + + S
Sbjct: 248 DWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFG----TSKELSDKSTKMSF 303
Query: 425 GIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFK 580
+G + ++APE+IR P S+ DI++FG V +ELL GE P+K
Sbjct: 304 ---AGTVAWMAPEVIRNE--------PVSEKVDIWSFGVVLWELLTGEIPYK 344
>BC001401-1|AAH01401.1| 455|Homo sapiens sterile alpha motif and
leucine zipper containing kinase AZK protein.
Length = 455
Score = 80.6 bits (190), Expect = 5e-15
Identities = 55/172 (31%), Positives = 88/172 (51%), Gaps = 5/172 (2%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHL-RKDKFTANKSVLVAQ 259
E I H N++ F G ++PP IVT +LY +I+ R ++ + + A
Sbjct: 53 EAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWAT 112
Query: 260 QISQGMGYLHARG---IIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLG 427
+++GM YLH +IH+DLK++N+ + + G + I DFG F N+ SL
Sbjct: 113 DVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR-----FHNHTTHMSL- 166
Query: 428 IPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKG 583
G ++APE+I++L P S+ D Y++G V +E+L E PFKG
Sbjct: 167 --VGTFPWMAPEVIQSL--------PVSETCDTYSYGVVLWEMLTREVPFKG 208
>AF480462-1|AAL85892.1| 455|Homo sapiens mixed lineage
kinase-related kinase MRK-beta protein.
Length = 455
Score = 80.6 bits (190), Expect = 5e-15
Identities = 55/172 (31%), Positives = 88/172 (51%), Gaps = 5/172 (2%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHL-RKDKFTANKSVLVAQ 259
E I H N++ F G ++PP IVT +LY +I+ R ++ + + A
Sbjct: 53 EAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWAT 112
Query: 260 QISQGMGYLHARG---IIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLG 427
+++GM YLH +IH+DLK++N+ + + G + I DFG F N+ SL
Sbjct: 113 DVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR-----FHNHTTHMSL- 166
Query: 428 IPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKG 583
G ++APE+I++L P S+ D Y++G V +E+L E PFKG
Sbjct: 167 --VGTFPWMAPEVIQSL--------PVSETCDTYSYGVVLWEMLTREVPFKG 208
>AF480461-1|AAL85891.1| 800|Homo sapiens mixed lineage
kinase-related kinase MRK-alpha protein.
Length = 800
Score = 80.6 bits (190), Expect = 5e-15
Identities = 55/172 (31%), Positives = 88/172 (51%), Gaps = 5/172 (2%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHL-RKDKFTANKSVLVAQ 259
E I H N++ F G ++PP IVT +LY +I+ R ++ + + A
Sbjct: 53 EAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWAT 112
Query: 260 QISQGMGYLHARG---IIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLG 427
+++GM YLH +IH+DLK++N+ + + G + I DFG F N+ SL
Sbjct: 113 DVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR-----FHNHTTHMSL- 166
Query: 428 IPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKG 583
G ++APE+I++L P S+ D Y++G V +E+L E PFKG
Sbjct: 167 --VGTFPWMAPEVIQSL--------PVSETCDTYSYGVVLWEMLTREVPFKG 208
>AF465843-1|AAO33376.1| 312|Homo sapiens cervical cancer suppressor
gene-4 protein protein.
Length = 312
Score = 80.6 bits (190), Expect = 5e-15
Identities = 55/172 (31%), Positives = 88/172 (51%), Gaps = 5/172 (2%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHL-RKDKFTANKSVLVAQ 259
E I H N++ F G ++PP IVT +LY +I+ R ++ + + A
Sbjct: 53 EAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWAT 112
Query: 260 QISQGMGYLHARG---IIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLG 427
+++GM YLH +IH+DLK++N+ + + G + I DFG F N+ SL
Sbjct: 113 DVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR-----FHNHTTHMSL- 166
Query: 428 IPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKG 583
G ++APE+I++L P S+ D Y++G V +E+L E PFKG
Sbjct: 167 --VGTFPWMAPEVIQSL--------PVSETCDTYSYGVVLWEMLTREVPFKG 208
>AF325454-1|AAK11615.1| 455|Homo sapiens mixed lineage kinase
protein.
Length = 455
Score = 80.6 bits (190), Expect = 5e-15
Identities = 55/172 (31%), Positives = 88/172 (51%), Gaps = 5/172 (2%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHL-RKDKFTANKSVLVAQ 259
E I H N++ F G ++PP IVT +LY +I+ R ++ + + A
Sbjct: 53 EAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWAT 112
Query: 260 QISQGMGYLHARG---IIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLG 427
+++GM YLH +IH+DLK++N+ + + G + I DFG F N+ SL
Sbjct: 113 DVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR-----FHNHTTHMSL- 166
Query: 428 IPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKG 583
G ++APE+I++L P S+ D Y++G V +E+L E PFKG
Sbjct: 167 --VGTFPWMAPEVIQSL--------PVSETCDTYSYGVVLWEMLTREVPFKG 208
>AF283475-1|AAL67158.1| 859|Homo sapiens zipper protein kinase
protein.
Length = 859
Score = 80.6 bits (190), Expect = 5e-15
Identities = 56/172 (32%), Positives = 86/172 (50%), Gaps = 1/172 (0%)
Frame = +2
Query: 68 DTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSV 247
D + ++ RK +H N++ F G C + P I+ C LY + + T + V
Sbjct: 156 DLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRP-VTPSLLV 214
Query: 248 LVAQQISQGMGYLHARGIIHKDLKTKNIFLESGKVV-ITDFGLFSVTKLCFGNNARGDSL 424
+ I+ GM YLH IIH+DLK+ N+ + VV I+DFG T + + S
Sbjct: 215 DWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFG----TSKELSDKSTKMSF 270
Query: 425 GIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFK 580
+G + ++APE+IR P S+ DI++FG V +ELL GE P+K
Sbjct: 271 ---AGTVAWMAPEVIRNE--------PVSEKVDIWSFGVVLWELLTGEIPYK 311
>AF251441-1|AAF65822.1| 800|Homo sapiens sterile-alpha motif and
leucine zipper containing kinase AZK protein.
Length = 800
Score = 80.6 bits (190), Expect = 5e-15
Identities = 55/172 (31%), Positives = 88/172 (51%), Gaps = 5/172 (2%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHL-RKDKFTANKSVLVAQ 259
E I H N++ F G ++PP IVT +LY +I+ R ++ + + A
Sbjct: 53 EAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWAT 112
Query: 260 QISQGMGYLHARG---IIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLG 427
+++GM YLH +IH+DLK++N+ + + G + I DFG F N+ SL
Sbjct: 113 DVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR-----FHNHTTHMSL- 166
Query: 428 IPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKG 583
G ++APE+I++L P S+ D Y++G V +E+L E PFKG
Sbjct: 167 --VGTFPWMAPEVIQSL--------PVSETCDTYSYGVVLWEMLTREVPFKG 208
>AF238255-1|AAF63490.1| 800|Homo sapiens mixed lineage kinase ZAK
protein.
Length = 800
Score = 80.6 bits (190), Expect = 5e-15
Identities = 55/172 (31%), Positives = 88/172 (51%), Gaps = 5/172 (2%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHL-RKDKFTANKSVLVAQ 259
E I H N++ F G ++PP IVT +LY +I+ R ++ + + A
Sbjct: 53 EAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWAT 112
Query: 260 QISQGMGYLHARG---IIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLG 427
+++GM YLH +IH+DLK++N+ + + G + I DFG F N+ SL
Sbjct: 113 DVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR-----FHNHTTHMSL- 166
Query: 428 IPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKG 583
G ++APE+I++L P S+ D Y++G V +E+L E PFKG
Sbjct: 167 --VGTFPWMAPEVIQSL--------PVSETCDTYSYGVVLWEMLTREVPFKG 208
>AB208974-1|BAD92211.1| 845|Homo sapiens Plaucible mixed-lineage
kinase protein variant protein.
Length = 845
Score = 80.6 bits (190), Expect = 5e-15
Identities = 55/172 (31%), Positives = 88/172 (51%), Gaps = 5/172 (2%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHL-RKDKFTANKSVLVAQ 259
E I H N++ F G ++PP IVT +LY +I+ R ++ + + A
Sbjct: 98 EAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWAT 157
Query: 260 QISQGMGYLHARG---IIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLG 427
+++GM YLH +IH+DLK++N+ + + G + I DFG F N+ SL
Sbjct: 158 DVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR-----FHNHTTHMSL- 211
Query: 428 IPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKG 583
G ++APE+I++L P S+ D Y++G V +E+L E PFKG
Sbjct: 212 --VGTFPWMAPEVIQSL--------PVSETCDTYSYGVVLWEMLTREVPFKG 253
>AB049734-1|BAB16445.1| 455|Homo sapiens MLTK-beta protein.
Length = 455
Score = 80.6 bits (190), Expect = 5e-15
Identities = 55/172 (31%), Positives = 88/172 (51%), Gaps = 5/172 (2%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHL-RKDKFTANKSVLVAQ 259
E I H N++ F G ++PP IVT +LY +I+ R ++ + + A
Sbjct: 53 EAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWAT 112
Query: 260 QISQGMGYLHARG---IIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLG 427
+++GM YLH +IH+DLK++N+ + + G + I DFG F N+ SL
Sbjct: 113 DVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR-----FHNHTTHMSL- 166
Query: 428 IPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKG 583
G ++APE+I++L P S+ D Y++G V +E+L E PFKG
Sbjct: 167 --VGTFPWMAPEVIQSL--------PVSETCDTYSYGVVLWEMLTREVPFKG 208
>AB049733-1|BAB16444.1| 800|Homo sapiens MLTK-alpha protein.
Length = 800
Score = 80.6 bits (190), Expect = 5e-15
Identities = 55/172 (31%), Positives = 88/172 (51%), Gaps = 5/172 (2%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHL-RKDKFTANKSVLVAQ 259
E I H N++ F G ++PP IVT +LY +I+ R ++ + + A
Sbjct: 53 EAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWAT 112
Query: 260 QISQGMGYLHARG---IIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLG 427
+++GM YLH +IH+DLK++N+ + + G + I DFG F N+ SL
Sbjct: 113 DVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR-----FHNHTTHMSL- 166
Query: 428 IPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKG 583
G ++APE+I++L P S+ D Y++G V +E+L E PFKG
Sbjct: 167 --VGTFPWMAPEVIQSL--------PVSETCDTYSYGVVLWEMLTREVPFKG 208
>AB030034-1|BAB12040.1| 800|Homo sapiens plaucible mixed-lineage
kinase protein protein.
Length = 800
Score = 80.6 bits (190), Expect = 5e-15
Identities = 55/172 (31%), Positives = 88/172 (51%), Gaps = 5/172 (2%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHL-RKDKFTANKSVLVAQ 259
E I H N++ F G ++PP IVT +LY +I+ R ++ + + A
Sbjct: 53 EAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWAT 112
Query: 260 QISQGMGYLHARG---IIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLG 427
+++GM YLH +IH+DLK++N+ + + G + I DFG F N+ SL
Sbjct: 113 DVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR-----FHNHTTHMSL- 166
Query: 428 IPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKG 583
G ++APE+I++L P S+ D Y++G V +E+L E PFKG
Sbjct: 167 --VGTFPWMAPEVIQSL--------PVSETCDTYSYGVVLWEMLTREVPFKG 208
>BC035782-1|AAH35782.1| 661|Homo sapiens TNK1 protein protein.
Length = 661
Score = 80.2 bits (189), Expect = 6e-15
Identities = 64/197 (32%), Positives = 92/197 (46%), Gaps = 4/197 (2%)
Frame = +2
Query: 14 VAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMT 193
VAVK L V P G+ L F EVS+ H +++ G + P L +V L +
Sbjct: 145 VAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQP-LQMVMELAPLGS 203
Query: 194 LYTHIHLRKDK--FTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLESGKVV-ITD 364
L+ + L +Q++ M YL ARG++H+DL T+N+ L S + + + D
Sbjct: 204 LHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVAD 263
Query: 365 FGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFG-T 541
FGL G G IP W C APE +R H + FS A+D++ FG T
Sbjct: 264 FGLVRPLGGARGRYVMGGPRPIPYAW-C--APESLR----HGA----FSSASDVWMFGVT 312
Query: 542 VWYELLCGEFPFKGQPP 592
+W GE P+ G PP
Sbjct: 313 LWEMFSGGEEPWAGVPP 329
>AF097738-1|AAC99412.1| 661|Homo sapiens non-receptor tyosine
kinase protein.
Length = 661
Score = 80.2 bits (189), Expect = 6e-15
Identities = 64/197 (32%), Positives = 92/197 (46%), Gaps = 4/197 (2%)
Frame = +2
Query: 14 VAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMT 193
VAVK L V P G+ L F EVS+ H +++ G + P L +V L +
Sbjct: 145 VAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQP-LQMVMELAPLGS 203
Query: 194 LYTHIHLRKDK--FTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLESGKVV-ITD 364
L+ + L +Q++ M YL ARG++H+DL T+N+ L S + + + D
Sbjct: 204 LHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVAD 263
Query: 365 FGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFG-T 541
FGL G G IP W C APE +R H + FS A+D++ FG T
Sbjct: 264 FGLVRPLGGARGRYVMGGPRPIPYAW-C--APESLR----HGA----FSSASDVWMFGVT 312
Query: 542 VWYELLCGEFPFKGQPP 592
+W GE P+ G PP
Sbjct: 313 LWEMFSGGEEPWAGVPP 329
>AC013461-1|AAX93067.1| 400|Homo sapiens unknown protein.
Length = 400
Score = 79.0 bits (186), Expect = 1e-14
Identities = 53/163 (32%), Positives = 86/163 (52%), Gaps = 5/163 (3%)
Frame = +2
Query: 110 HENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHL-RKDKFTANKSVLVAQQISQGMGYL 286
H N++ F G ++PP IVT +LY +I+ R ++ + + A +++GM YL
Sbjct: 9 HRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYL 68
Query: 287 HARG---IIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYL 454
H +IH+DLK++N+ + + G + I DFG F N+ SL G ++
Sbjct: 69 HMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR-----FHNHTTHMSL---VGTFPWM 120
Query: 455 APEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKG 583
APE+I++L P S+ D Y++G V +E+L E PFKG
Sbjct: 121 APEVIQSL--------PVSETCDTYSYGVVLWEMLTREVPFKG 155
>U43408-1|AAC50427.1| 666|Homo sapiens tyrosine kinase protein.
Length = 666
Score = 78.2 bits (184), Expect = 2e-14
Identities = 64/197 (32%), Positives = 92/197 (46%), Gaps = 4/197 (2%)
Frame = +2
Query: 14 VAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMT 193
VAVK L V P G+ L F EVS+ H +++ G + P L +V L +
Sbjct: 145 VAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQP-LQMVMELAPLGS 203
Query: 194 LYTHIHLRKDK--FTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLESGKVV-ITD 364
L+ + L +Q++ M YL ARG++H+DL T+N+ L S + + + D
Sbjct: 204 LHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLQLASPRTIKVAD 263
Query: 365 FGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFG-T 541
FGL G G IP W C APE +R H + FS A+D++ FG T
Sbjct: 264 FGLVRPLGGARGRYVMGGPRPIPYTW-C--APESLR----HGA----FSSASDVWMFGVT 312
Query: 542 VWYELLCGEFPFKGQPP 592
+W GE P+ G PP
Sbjct: 313 LWEMFSGGEEPWPGVPP 329
>M95936-1|AAA58364.1| 481|Homo sapiens protein serine/threonine
kinase protein.
Length = 481
Score = 77.8 bits (183), Expect = 3e-14
Identities = 51/174 (29%), Positives = 81/174 (46%), Gaps = 1/174 (0%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E + + TRH L A RL V G L+ H+ R+ FT ++ +
Sbjct: 200 ESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLS-RERVFTEERARFYGAE 258
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFLE-SGKVVITDFGLFSVTKLCFGNNARGDSLGIPSG 439
I + YLH+R ++++D+K +N+ L+ G + ITDFG LC + G ++ G
Sbjct: 259 IVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFG------LCKEGISDGATMKTFCG 312
Query: 440 WLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESI 601
YLAPE++ + +A D + G V YE++CG PF Q E +
Sbjct: 313 TPEYLAPEVLED--------NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERL 358
>M77198-1|AAA36585.1| 520|Homo sapiens rac protein kinase-beta
protein.
Length = 520
Score = 77.8 bits (183), Expect = 3e-14
Identities = 51/174 (29%), Positives = 81/174 (46%), Gaps = 1/174 (0%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E + + TRH L A RL V G L+ H+ R+ FT ++ +
Sbjct: 200 ESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLS-RERVFTEERARFYGAE 258
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFLE-SGKVVITDFGLFSVTKLCFGNNARGDSLGIPSG 439
I + YLH+R ++++D+K +N+ L+ G + ITDFG LC + G ++ G
Sbjct: 259 IVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFG------LCKEGISDGATMKTFCG 312
Query: 440 WLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESI 601
YLAPE++ + +A D + G V YE++CG PF Q E +
Sbjct: 313 TPEYLAPEVLED--------NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERL 358
>BC120994-1|AAI20995.1| 481|Homo sapiens v-akt murine thymoma viral
oncogene homolog 2 protein.
Length = 481
Score = 77.8 bits (183), Expect = 3e-14
Identities = 51/174 (29%), Positives = 81/174 (46%), Gaps = 1/174 (0%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E + + TRH L A RL V G L+ H+ R+ FT ++ +
Sbjct: 200 ESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLS-RERVFTEERARFYGAE 258
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFLE-SGKVVITDFGLFSVTKLCFGNNARGDSLGIPSG 439
I + YLH+R ++++D+K +N+ L+ G + ITDFG LC + G ++ G
Sbjct: 259 IVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFG------LCKEGISDGATMKTFCG 312
Query: 440 WLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESI 601
YLAPE++ + +A D + G V YE++CG PF Q E +
Sbjct: 313 TPEYLAPEVLED--------NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERL 358
>Z98752-8|CAC18509.1| 367|Homo sapiens serum/glucocorticoid
regulated kinase 2 protein.
Length = 367
Score = 77.4 bits (182), Expect = 4e-14
Identities = 54/166 (32%), Positives = 81/166 (48%), Gaps = 1/166 (0%)
Frame = +2
Query: 92 IFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQ 271
+ + RH LV + P +L V G L+ H+ R+ +F ++ A +++
Sbjct: 87 LLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQ-RERRFLEPRARFYAAEVAS 145
Query: 272 GMGYLHARGIIHKDLKTKNIFLE-SGKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLC 448
+GYLH+ II++DLK +NI L+ G VV+TDFG LC D+ G
Sbjct: 146 AIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFG------LCKEGVEPEDTTSTFCGTPE 199
Query: 449 YLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQ 586
YLAPE++R P+ +A D + G V YE+L G PF Q
Sbjct: 200 YLAPEVLRK--------EPYDRAVDWWCLGAVLYEMLHGLPPFYSQ 237
>Z98752-7|CAI42315.1| 366|Homo sapiens serum/glucocorticoid
regulated kinase 2 protein.
Length = 366
Score = 77.4 bits (182), Expect = 4e-14
Identities = 54/166 (32%), Positives = 81/166 (48%), Gaps = 1/166 (0%)
Frame = +2
Query: 92 IFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQ 271
+ + RH LV + P +L V G L+ H+ R+ +F ++ A +++
Sbjct: 86 LLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQ-RERRFLEPRARFYAAEVAS 144
Query: 272 GMGYLHARGIIHKDLKTKNIFLE-SGKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLC 448
+GYLH+ II++DLK +NI L+ G VV+TDFG LC D+ G
Sbjct: 145 AIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFG------LCKEGVEPEDTTSTFCGTPE 198
Query: 449 YLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQ 586
YLAPE++R P+ +A D + G V YE+L G PF Q
Sbjct: 199 YLAPEVLRK--------EPYDRAVDWWCLGAVLYEMLHGLPPFYSQ 236
>Z98752-5|CAI42312.1| 427|Homo sapiens serum/glucocorticoid
regulated kinase 2 protein.
Length = 427
Score = 77.4 bits (182), Expect = 4e-14
Identities = 54/166 (32%), Positives = 81/166 (48%), Gaps = 1/166 (0%)
Frame = +2
Query: 92 IFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQ 271
+ + RH LV + P +L V G L+ H+ R+ +F ++ A +++
Sbjct: 147 LLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQ-RERRFLEPRARFYAAEVAS 205
Query: 272 GMGYLHARGIIHKDLKTKNIFLE-SGKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLC 448
+GYLH+ II++DLK +NI L+ G VV+TDFG LC D+ G
Sbjct: 206 AIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFG------LCKEGVEPEDTTSTFCGTPE 259
Query: 449 YLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQ 586
YLAPE++R P+ +A D + G V YE+L G PF Q
Sbjct: 260 YLAPEVLRK--------EPYDRAVDWWCLGAVLYEMLHGLPPFYSQ 297
>U07747-1|AAA19647.1| 847|Homo sapiens serine/threonine protein
kinase protein.
Length = 847
Score = 77.4 bits (182), Expect = 4e-14
Identities = 63/207 (30%), Positives = 95/207 (45%), Gaps = 13/207 (6%)
Frame = +2
Query: 2 WHGA-VAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSL 178
W G VAVK P D ++ + E +F H N++ C++ P L +V
Sbjct: 136 WRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEY 195
Query: 179 CKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARG---IIHKDLKTKNIFL---- 337
G L + R+ + V A QI++GM YLH +IH+DLK+ NI L
Sbjct: 196 AAGGPLSRALAGRR--VPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPI 253
Query: 338 -----ESGKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLL 502
E + ITDFGL +A +G ++APE+I+A
Sbjct: 254 ESDDMEHKTLKITDFGLAREWHKTTQMSA--------AGTYAWMAPEVIKAST------- 298
Query: 503 PFSKATDIYAFGTVWYELLCGEFPFKG 583
FSK +D+++FG + +ELL GE P++G
Sbjct: 299 -FSKGSDVWSFGVLLWELLTGEVPYRG 324
>L32976-1|AAA59859.1| 847|Homo sapiens protein kinase protein.
Length = 847
Score = 77.4 bits (182), Expect = 4e-14
Identities = 63/207 (30%), Positives = 95/207 (45%), Gaps = 13/207 (6%)
Frame = +2
Query: 2 WHGA-VAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSL 178
W G VAVK P D ++ + E +F H N++ C++ P L +V
Sbjct: 136 WRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEY 195
Query: 179 CKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARG---IIHKDLKTKNIFL---- 337
G L + R+ + V A QI++GM YLH +IH+DLK+ NI L
Sbjct: 196 AAGGPLSRALAGRR--VPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPI 253
Query: 338 -----ESGKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLL 502
E + ITDFGL +A +G ++APE+I+A
Sbjct: 254 ESDDMEHKTLKITDFGLAREWHKTTQMSA--------AGTYAWMAPEVIKAST------- 298
Query: 503 PFSKATDIYAFGTVWYELLCGEFPFKG 583
FSK +D+++FG + +ELL GE P++G
Sbjct: 299 -FSKGSDVWSFGVLLWELLTGEVPYRG 324
>BC065511-1|AAH65511.1| 367|Homo sapiens SGK2 protein protein.
Length = 367
Score = 77.4 bits (182), Expect = 4e-14
Identities = 54/166 (32%), Positives = 81/166 (48%), Gaps = 1/166 (0%)
Frame = +2
Query: 92 IFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQ 271
+ + RH LV + P +L V G L+ H+ R+ +F ++ A +++
Sbjct: 87 LLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQ-RERRFLEPRARFYAAEVAS 145
Query: 272 GMGYLHARGIIHKDLKTKNIFLE-SGKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLC 448
+GYLH+ II++DLK +NI L+ G VV+TDFG LC D+ G
Sbjct: 146 AIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFG------LCKEGVEPEDTTSTFCGTPE 199
Query: 449 YLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQ 586
YLAPE++R P+ +A D + G V YE+L G PF Q
Sbjct: 200 YLAPEVLRK--------EPYDRAVDWWCLGAVLYEMLHGLPPFYSQ 237
>BC064543-1|AAH64543.1| 847|Homo sapiens mitogen-activated protein
kinase kinase kinase 11 protein.
Length = 847
Score = 77.4 bits (182), Expect = 4e-14
Identities = 63/207 (30%), Positives = 95/207 (45%), Gaps = 13/207 (6%)
Frame = +2
Query: 2 WHGA-VAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSL 178
W G VAVK P D ++ + E +F H N++ C++ P L +V
Sbjct: 136 WRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEY 195
Query: 179 CKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARG---IIHKDLKTKNIFL---- 337
G L + R+ + V A QI++GM YLH +IH+DLK+ NI L
Sbjct: 196 AAGGPLSRALAGRR--VPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQHI 253
Query: 338 -----ESGKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLL 502
E + ITDFGL +A +G ++APE+I+A
Sbjct: 254 ESDDMEHKTLKITDFGLAREWHKTTQMSA--------AGTYAWMAPEVIKAST------- 298
Query: 503 PFSKATDIYAFGTVWYELLCGEFPFKG 583
FSK +D+++FG + +ELL GE P++G
Sbjct: 299 -FSKGSDVWSFGVLLWELLTGEVPYRG 324
>BC014037-1|AAH14037.3| 367|Homo sapiens serum/glucocorticoid
regulated kinase 2 protein.
Length = 367
Score = 77.4 bits (182), Expect = 4e-14
Identities = 54/166 (32%), Positives = 81/166 (48%), Gaps = 1/166 (0%)
Frame = +2
Query: 92 IFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQ 271
+ + RH LV + P +L V G L+ H+ R+ +F ++ A +++
Sbjct: 87 LLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQ-RERRFLEPRARFYAAEVAS 145
Query: 272 GMGYLHARGIIHKDLKTKNIFLE-SGKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLC 448
+GYLH+ II++DLK +NI L+ G VV+TDFG LC D+ G
Sbjct: 146 AIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFG------LCKEGVEPEDTTSTFCGTPE 199
Query: 449 YLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQ 586
YLAPE++R P+ +A D + G V YE+L G PF Q
Sbjct: 200 YLAPEVLRK--------EPYDRAVDWWCLGAVLYEMLHGLPPFYSQ 237
>BC011263-1|AAH11263.1| 847|Homo sapiens mitogen-activated protein
kinase kinase kinase 11 protein.
Length = 847
Score = 77.4 bits (182), Expect = 4e-14
Identities = 63/207 (30%), Positives = 95/207 (45%), Gaps = 13/207 (6%)
Frame = +2
Query: 2 WHGA-VAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSL 178
W G VAVK P D ++ + E +F H N++ C++ P L +V
Sbjct: 136 WRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEY 195
Query: 179 CKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARG---IIHKDLKTKNIFL---- 337
G L + R+ + V A QI++GM YLH +IH+DLK+ NI L
Sbjct: 196 AAGGPLSRALAGRR--VPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPI 253
Query: 338 -----ESGKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLL 502
E + ITDFGL +A +G ++APE+I+A
Sbjct: 254 ESDDMEHKTLKITDFGLAREWHKTTQMSA--------AGTYAWMAPEVIKAST------- 298
Query: 503 PFSKATDIYAFGTVWYELLCGEFPFKG 583
FSK +D+++FG + +ELL GE P++G
Sbjct: 299 -FSKGSDVWSFGVLLWELLTGEVPYRG 324
>AK222781-1|BAD96501.1| 847|Homo sapiens mitogen-activated protein
kinase kinase kinase 11 variant protein.
Length = 847
Score = 77.4 bits (182), Expect = 4e-14
Identities = 63/207 (30%), Positives = 95/207 (45%), Gaps = 13/207 (6%)
Frame = +2
Query: 2 WHGA-VAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSL 178
W G VAVK P D ++ + E +F H N++ C++ P L +V
Sbjct: 136 WRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEY 195
Query: 179 CKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARG---IIHKDLKTKNIFL---- 337
G L + R+ + V A QI++GM YLH +IH+DLK+ NI L
Sbjct: 196 AAGGPLSRALAGRR--VPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPI 253
Query: 338 -----ESGKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLL 502
E + ITDFGL +A +G ++APE+I+A
Sbjct: 254 ESDDMEHKTLKITDFGLAREWHKTTQMSA--------AGTYAWMAPEVIKAST------- 298
Query: 503 PFSKATDIYAFGTVWYELLCGEFPFKG 583
FSK +D+++FG + +ELL GE P++G
Sbjct: 299 -FSKGSDVWSFGVLLWELLTGEVPYRG 324
>AF186470-1|AAG17012.1| 427|Homo sapiens protein kinase protein.
Length = 427
Score = 77.4 bits (182), Expect = 4e-14
Identities = 54/166 (32%), Positives = 81/166 (48%), Gaps = 1/166 (0%)
Frame = +2
Query: 92 IFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQ 271
+ + RH LV + P +L V G L+ H+ R+ +F ++ A +++
Sbjct: 147 LLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQ-RERRFLEPRARFYAAEVAS 205
Query: 272 GMGYLHARGIIHKDLKTKNIFLE-SGKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLC 448
+GYLH+ II++DLK +NI L+ G VV+TDFG LC D+ G
Sbjct: 206 AIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFG------LCKEGVEPEDTTSTFCGTPE 259
Query: 449 YLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQ 586
YLAPE++R P+ +A D + G V YE+L G PF Q
Sbjct: 260 YLAPEVLRK--------EPYDRAVDWWCLGAVLYEMLHGLPPFYSQ 297
>AF169034-1|AAF12757.2| 367|Homo sapiens protein kinase protein.
Length = 367
Score = 77.4 bits (182), Expect = 4e-14
Identities = 54/166 (32%), Positives = 81/166 (48%), Gaps = 1/166 (0%)
Frame = +2
Query: 92 IFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQ 271
+ + RH LV + P +L V G L+ H+ R+ +F ++ A +++
Sbjct: 87 LLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQ-RERRFLEPRARFYAAEVAS 145
Query: 272 GMGYLHARGIIHKDLKTKNIFLE-SGKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLC 448
+GYLH+ II++DLK +NI L+ G VV+TDFG LC D+ G
Sbjct: 146 AIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFG------LCKEGVEPEDTTSTFCGTPE 199
Query: 449 YLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQ 586
YLAPE++R P+ +A D + G V YE+L G PF Q
Sbjct: 200 YLAPEVLRK--------EPYDRAVDWWCLGAVLYEMLHGLPPFYSQ 237
>BC063885-1|AAH63885.1| 708|Homo sapiens NIMA (never in mitosis
gene a)-related kinase 5 protein.
Length = 708
Score = 77.0 bits (181), Expect = 6e-14
Identities = 56/172 (32%), Positives = 85/172 (49%), Gaps = 3/172 (1%)
Frame = +2
Query: 77 KHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLV- 253
K EV + K +H N+V F + + RL IV C G L I+ ++ + +L
Sbjct: 49 KKEVILLEKMKHPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGW 108
Query: 254 AQQISQGMGYLHARGIIHKDLKTKNIFLESGKVV--ITDFGLFSVTKLCFGNNARGDSLG 427
QIS G+ ++H R I+H+D+K +NIFL +V + DFG+ V L +G
Sbjct: 109 FVQISLGLKHIHDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARV--LNNSMELARTCIG 166
Query: 428 IPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKG 583
P YL+PEI + P++ TDI++ G V YEL + PF+G
Sbjct: 167 TP----YYLSPEICQN--------KPYNNKTDIWSLGCVLYELCTLKHPFEG 206
>AL139082-5|CAI12892.2| 708|Homo sapiens NIMA (never in mitosis
gene a)-related kinase 5 protein.
Length = 708
Score = 77.0 bits (181), Expect = 6e-14
Identities = 56/172 (32%), Positives = 85/172 (49%), Gaps = 3/172 (1%)
Frame = +2
Query: 77 KHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLV- 253
K EV + K +H N+V F + + RL IV C G L I+ ++ + +L
Sbjct: 49 KKEVILLEKMKHPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGW 108
Query: 254 AQQISQGMGYLHARGIIHKDLKTKNIFLESGKVV--ITDFGLFSVTKLCFGNNARGDSLG 427
QIS G+ ++H R I+H+D+K +NIFL +V + DFG+ V L +G
Sbjct: 109 FVQISLGLKHIHDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARV--LNNSMELARTCIG 166
Query: 428 IPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKG 583
P YL+PEI + P++ TDI++ G V YEL + PF+G
Sbjct: 167 TP----YYLSPEICQN--------KPYNNKTDIWSLGCVLYELCTLKHPFEG 206
>Z15114-1|CAA78820.1| 536|Homo sapiens protein kinase C gamma
protein.
Length = 536
Score = 76.6 bits (180), Expect = 7e-14
Identities = 53/155 (34%), Positives = 78/155 (50%), Gaps = 1/155 (0%)
Frame = +2
Query: 149 PPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKN 328
P RL V G L HI + KF + A +I+ G+ +LH +GII++DLK N
Sbjct: 266 PDRLYFVMEYVTGGDLMYHIQ-QLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDN 324
Query: 329 IFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLP 505
+ L++ G + ITDFG+ C N G + G Y+APEII P
Sbjct: 325 VMLDAEGHIKITDFGM------CKENVFPGTTTRTFCGTPDYIAPEIIA--------YQP 370
Query: 506 FSKATDIYAFGTVWYELLCGEFPFKGQPPESIHLA 610
+ K+ D ++FG + YE+L G+ PF G+ E + A
Sbjct: 371 YGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQA 405
>BC073140-1|AAH73140.1| 414|Homo sapiens MAP kinase interacting
serine/threonine kinase 2 protein.
Length = 414
Score = 76.6 bits (180), Expect = 7e-14
Identities = 52/176 (29%), Positives = 87/176 (49%), Gaps = 5/176 (2%)
Frame = +2
Query: 74 FKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLV 253
F+ +++ H N++ + + R +V +G ++ +HIH R+ F ++ +V
Sbjct: 127 FREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRH-FNELEASVV 185
Query: 254 AQQISQGMGYLHARGIIHKDLKTKNIFLES----GKVVITDFGLFSVTKLCFG-NNARGD 418
Q ++ + +LH +GI H+DLK +NI E V I DF L S KL +
Sbjct: 186 VQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTP 245
Query: 419 SLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQ 586
L P G Y+APE++ A AS+ + K D+++ G + Y LL G PF G+
Sbjct: 246 ELLTPCGSAEYMAPEVVEAFSEEASI---YDKRCDLWSLGVILYILLSGYPPFVGR 298
>BC047876-1|AAH47876.1| 697|Homo sapiens protein kinase C, gamma
protein.
Length = 697
Score = 76.6 bits (180), Expect = 7e-14
Identities = 53/155 (34%), Positives = 78/155 (50%), Gaps = 1/155 (0%)
Frame = +2
Query: 149 PPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKN 328
P RL V G L HI + KF + A +I+ G+ +LH +GII++DLK N
Sbjct: 427 PDRLYFVMEYVTGGDLMYHIQ-QLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDN 485
Query: 329 IFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLP 505
+ L++ G + ITDFG+ C N G + G Y+APEII P
Sbjct: 486 VMLDAEGHIKITDFGM------CKENVFPGTTTRTFCGTPDYIAPEIIA--------YQP 531
Query: 506 FSKATDIYAFGTVWYELLCGEFPFKGQPPESIHLA 610
+ K+ D ++FG + YE+L G+ PF G+ E + A
Sbjct: 532 YGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQA 566
>AY987010-1|AAX88805.1| 393|Homo sapiens serum/glucocorticoid
regulated kinase 2 protein.
Length = 393
Score = 76.6 bits (180), Expect = 7e-14
Identities = 54/166 (32%), Positives = 80/166 (48%), Gaps = 1/166 (0%)
Frame = +2
Query: 92 IFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQ 271
+ + RH LV + P L V G L+ H+ R+ +F ++ A +++
Sbjct: 113 LLKNVRHPFLVGLRYSFQTPEELYFVLDYVNGGELFFHLQ-RERRFLEPRARFYAAEVAS 171
Query: 272 GMGYLHARGIIHKDLKTKNIFLE-SGKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLC 448
+GYLH+ II++DLK +NI L+ G VV+TDFG LC D+ G
Sbjct: 172 AIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFG------LCKEGVEPEDTTSTFCGTPE 225
Query: 449 YLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQ 586
YLAPE++R P+ +A D + G V YE+L G PF Q
Sbjct: 226 YLAPEVLRK--------EPYDRAVDWWCLGAVLYEMLHGLPPFYSQ 263
>AL137565-1|CAB70816.1| 316|Homo sapiens hypothetical protein
protein.
Length = 316
Score = 76.6 bits (180), Expect = 7e-14
Identities = 52/176 (29%), Positives = 87/176 (49%), Gaps = 5/176 (2%)
Frame = +2
Query: 74 FKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLV 253
F+ +++ H N++ + + R +V +G ++ +HIH R+ F ++ +V
Sbjct: 29 FREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRH-FNELEASVV 87
Query: 254 AQQISQGMGYLHARGIIHKDLKTKNIFLES----GKVVITDFGLFSVTKLCFG-NNARGD 418
Q ++ + +LH +GI H+DLK +NI E V I DF L S KL +
Sbjct: 88 VQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTP 147
Query: 419 SLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQ 586
L P G Y+APE++ A AS+ + K D+++ G + Y LL G PF G+
Sbjct: 148 ELLTPCGSAEYMAPEVVEAFSEEASI---YDKRCDLWSLGVILYILLSGYPPFVGR 200
>AF345987-1|AAK13533.1| 697|Homo sapiens protein kinase C gamma
protein.
Length = 697
Score = 76.6 bits (180), Expect = 7e-14
Identities = 53/155 (34%), Positives = 78/155 (50%), Gaps = 1/155 (0%)
Frame = +2
Query: 149 PPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKN 328
P RL V G L HI + KF + A +I+ G+ +LH +GII++DLK N
Sbjct: 427 PDRLYFVMEYVTGGDLMYHIQ-QLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDN 485
Query: 329 IFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLP 505
+ L++ G + ITDFG+ C N G + G Y+APEII P
Sbjct: 486 VMLDAEGHIKITDFGM------CKENVFPGTTTRTFCGTPDYIAPEIIA--------YQP 531
Query: 506 FSKATDIYAFGTVWYELLCGEFPFKGQPPESIHLA 610
+ K+ D ++FG + YE+L G+ PF G+ E + A
Sbjct: 532 YGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQA 566
>AF237776-1|AAG26337.1| 414|Homo sapiens MAP kinase-interacting
kinase 2b protein.
Length = 414
Score = 76.6 bits (180), Expect = 7e-14
Identities = 52/176 (29%), Positives = 87/176 (49%), Gaps = 5/176 (2%)
Frame = +2
Query: 74 FKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLV 253
F+ +++ H N++ + + R +V +G ++ +HIH R+ F ++ +V
Sbjct: 127 FREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRH-FNELEASVV 185
Query: 254 AQQISQGMGYLHARGIIHKDLKTKNIFLES----GKVVITDFGLFSVTKLCFG-NNARGD 418
Q ++ + +LH +GI H+DLK +NI E V I DF L S KL +
Sbjct: 186 VQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTP 245
Query: 419 SLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQ 586
L P G Y+APE++ A AS+ + K D+++ G + Y LL G PF G+
Sbjct: 246 ELLTPCGSAEYMAPEVVEAFSEEASI---YDKRCDLWSLGVILYILLSGYPPFVGR 298
>AF237775-1|AAG26336.1| 465|Homo sapiens MAP kinase-interacting
kinase 2a protein.
Length = 465
Score = 76.6 bits (180), Expect = 7e-14
Identities = 52/176 (29%), Positives = 87/176 (49%), Gaps = 5/176 (2%)
Frame = +2
Query: 74 FKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLV 253
F+ +++ H N++ + + R +V +G ++ +HIH R+ F ++ +V
Sbjct: 127 FREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRH-FNELEASVV 185
Query: 254 AQQISQGMGYLHARGIIHKDLKTKNIFLES----GKVVITDFGLFSVTKLCFG-NNARGD 418
Q ++ + +LH +GI H+DLK +NI E V I DF L S KL +
Sbjct: 186 VQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTP 245
Query: 419 SLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQ 586
L P G Y+APE++ A AS+ + K D+++ G + Y LL G PF G+
Sbjct: 246 ELLTPCGSAEYMAPEVVEAFSEEASI---YDKRCDLWSLGVILYILLSGYPPFVGR 298
>AC007136-1|AAD21217.1| 472|Homo sapiens Putative map kinase
interacting kinase [Homo sapiens] protein.
Length = 472
Score = 76.6 bits (180), Expect = 7e-14
Identities = 52/176 (29%), Positives = 87/176 (49%), Gaps = 5/176 (2%)
Frame = +2
Query: 74 FKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLV 253
F+ +++ H N++ + + R +V +G ++ +HIH R+ F ++ +V
Sbjct: 134 FREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRH-FNELEASVV 192
Query: 254 AQQISQGMGYLHARGIIHKDLKTKNIFLES----GKVVITDFGLFSVTKLCFG-NNARGD 418
Q ++ + +LH +GI H+DLK +NI E V I DF L S KL +
Sbjct: 193 VQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTP 252
Query: 419 SLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQ 586
L P G Y+APE++ A AS+ + K D+++ G + Y LL G PF G+
Sbjct: 253 ELLTPCGSAEYMAPEVVEAFSEEASI---YDKRCDLWSLGVILYILLSGYPPFVGR 305
>D79997-1|BAA11492.2| 656|Homo sapiens KIAA0175 protein.
Length = 656
Score = 76.2 bits (179), Expect = 1e-13
Identities = 58/209 (27%), Positives = 101/209 (48%), Gaps = 1/209 (0%)
Frame = +2
Query: 14 VAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMT 193
VA+K++ L D L K E+ + RH+++ ++ +V C G
Sbjct: 42 VAIKIMDKNTLGSD---LPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGE 98
Query: 194 LYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKN-IFLESGKVVITDFG 370
L+ +I + +D+ + ++ +V +QI + Y+H++G H+DLK +N +F E K+ + DFG
Sbjct: 99 LFDYI-ISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFG 157
Query: 371 LFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWY 550
L + K GN + L G L Y APE+I+ S L D+++ G + Y
Sbjct: 158 LCAKPK---GN--KDYHLQTCCGSLAYAAPELIQG----KSYL---GSEADVWSMGILLY 205
Query: 551 ELLCGEFPFKGQPPESIHLASR*GREAVP 637
L+CG PF +++ G+ VP
Sbjct: 206 VLMCGFLPFDDDNVMALYKKIMRGKYDVP 234
>BC126182-1|AAI26183.1| 385|Homo sapiens protein serine kinase H2
protein.
Length = 385
Score = 76.2 bits (179), Expect = 1e-13
Identities = 51/170 (30%), Positives = 84/170 (49%), Gaps = 5/170 (2%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E+S+ R+ H +V M ++ +V L G L+ + + + FT +V + Q
Sbjct: 108 ELSVLRRVSHRYIVQLMEIFETEDQVYMVMELATGGELFDRL-IAQGSFTERDAVRILQM 166
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFL----ESGKVVITDFGLFSVTKLCFGNNARGD-SLG 427
++ G+ YLHA I H++LK +N+ E K++ITDFG L + GD ++
Sbjct: 167 VADGIRYLHALQITHRNLKPENLLYYHPGEESKILITDFG------LAYSGKKSGDWTMK 220
Query: 428 IPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
G Y+APE++ L P++ A D++A G + Y LL G PF
Sbjct: 221 TLCGTPEYIAPEVL--------LRKPYTSAVDMWALGVITYALLSGFLPF 262
>BC126180-1|AAI26181.1| 385|Homo sapiens protein serine kinase H2
protein.
Length = 385
Score = 76.2 bits (179), Expect = 1e-13
Identities = 51/170 (30%), Positives = 84/170 (49%), Gaps = 5/170 (2%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E+S+ R+ H +V M ++ +V L G L+ + + + FT +V + Q
Sbjct: 108 ELSVLRRVSHRYIVQLMEIFETEDQVYMVMELATGGELFDRL-IAQGSFTERDAVRILQM 166
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFL----ESGKVVITDFGLFSVTKLCFGNNARGD-SLG 427
++ G+ YLHA I H++LK +N+ E K++ITDFG L + GD ++
Sbjct: 167 VADGIRYLHALQITHRNLKPENLLYYHPGEESKILITDFG------LAYSGKKSGDWTMK 220
Query: 428 IPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
G Y+APE++ L P++ A D++A G + Y LL G PF
Sbjct: 221 TLCGTPEYIAPEVL--------LRKPYTSAVDMWALGVITYALLSGFLPF 262
>BC031231-1|AAH31231.1| 514|Homo sapiens serine/threonine kinase 33
protein.
Length = 514
Score = 76.2 bits (179), Expect = 1e-13
Identities = 57/191 (29%), Positives = 92/191 (48%), Gaps = 10/191 (5%)
Frame = +2
Query: 59 SLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTAN 238
S + + EV+I + +HE+++ P ++ +V LC+ L I RK F+ N
Sbjct: 155 SAVKLLEREVNILKSVKHEHIIHLEQVFETPKKMYLVMELCEDGEL-KEILDRKGHFSEN 213
Query: 239 KSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLESG----------KVVITDFGLFSVTK 388
++ + Q ++ + YLH I+H+DLK +NI ++S + +TDFGL +V K
Sbjct: 214 ETRWIIQSLASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGL-AVKK 272
Query: 389 LCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGE 568
+ G P Y+APE+I A H +S+ DI++ G V Y LL GE
Sbjct: 273 QSRSEAMLQATCGTP----IYMAPEVISA---H-----DYSQQCDIWSIGVVMYMLLRGE 320
Query: 569 FPFKGQPPESI 601
PF E +
Sbjct: 321 PPFLASSEEKL 331
>BC014039-1|AAH14039.1| 651|Homo sapiens maternal embryonic leucine
zipper kinase protein.
Length = 651
Score = 76.2 bits (179), Expect = 1e-13
Identities = 58/209 (27%), Positives = 101/209 (48%), Gaps = 1/209 (0%)
Frame = +2
Query: 14 VAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMT 193
VA+K++ L D L K E+ + RH+++ ++ +V C G
Sbjct: 37 VAIKIMDKNTLGSD---LPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGE 93
Query: 194 LYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKN-IFLESGKVVITDFG 370
L+ +I + +D+ + ++ +V +QI + Y+H++G H+DLK +N +F E K+ + DFG
Sbjct: 94 LFDYI-ISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFG 152
Query: 371 LFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWY 550
L + K GN + L G L Y APE+I+ S L D+++ G + Y
Sbjct: 153 LCAKPK---GN--KDYHLQTCCGSLAYAAPELIQG----KSYL---GSEADVWSMGILLY 200
Query: 551 ELLCGEFPFKGQPPESIHLASR*GREAVP 637
L+CG PF +++ G+ VP
Sbjct: 201 VLMCGFLPFDDDNVMALYKKIMRGKYDVP 229
>AY037806-1|AAK59985.1| 385|Homo sapiens serine/threonine kinase
PSKH2 protein.
Length = 385
Score = 76.2 bits (179), Expect = 1e-13
Identities = 51/170 (30%), Positives = 84/170 (49%), Gaps = 5/170 (2%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E+S+ R+ H +V M ++ +V L G L+ + + + FT +V + Q
Sbjct: 108 ELSVLRRVSHRYIVQLMEIFETEDQVYMVMELATGGELFDRL-IAQGSFTERDAVRILQM 166
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFL----ESGKVVITDFGLFSVTKLCFGNNARGD-SLG 427
++ G+ YLHA I H++LK +N+ E K++ITDFG L + GD ++
Sbjct: 167 VADGIRYLHALQITHRNLKPENLLYYHPGEESKILITDFG------LAYSGKKSGDWTMK 220
Query: 428 IPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
G Y+APE++ L P++ A D++A G + Y LL G PF
Sbjct: 221 TLCGTPEYIAPEVL--------LRKPYTSAVDMWALGVITYALLSGFLPF 262
>AL442063-1|CAI16995.2| 651|Homo sapiens maternal embryonic leucine
zipper kinase protein.
Length = 651
Score = 76.2 bits (179), Expect = 1e-13
Identities = 58/209 (27%), Positives = 101/209 (48%), Gaps = 1/209 (0%)
Frame = +2
Query: 14 VAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMT 193
VA+K++ L D L K E+ + RH+++ ++ +V C G
Sbjct: 37 VAIKIMDKNTLGSD---LPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGE 93
Query: 194 LYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKN-IFLESGKVVITDFG 370
L+ +I + +D+ + ++ +V +QI + Y+H++G H+DLK +N +F E K+ + DFG
Sbjct: 94 LFDYI-ISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFG 152
Query: 371 LFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWY 550
L + K GN + L G L Y APE+I+ S L D+++ G + Y
Sbjct: 153 LCAKPK---GN--KDYHLQTCCGSLAYAAPELIQG----KSYL---GSEADVWSMGILLY 200
Query: 551 ELLCGEFPFKGQPPESIHLASR*GREAVP 637
L+CG PF +++ G+ VP
Sbjct: 201 VLMCGFLPFDDDNVMALYKKIMRGKYDVP 229
>AL354932-1|CAI11034.2| 651|Homo sapiens maternal embryonic leucine
zipper kinase protein.
Length = 651
Score = 76.2 bits (179), Expect = 1e-13
Identities = 58/209 (27%), Positives = 101/209 (48%), Gaps = 1/209 (0%)
Frame = +2
Query: 14 VAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMT 193
VA+K++ L D L K E+ + RH+++ ++ +V C G
Sbjct: 37 VAIKIMDKNTLGSD---LPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGE 93
Query: 194 LYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKN-IFLESGKVVITDFG 370
L+ +I + +D+ + ++ +V +QI + Y+H++G H+DLK +N +F E K+ + DFG
Sbjct: 94 LFDYI-ISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFG 152
Query: 371 LFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWY 550
L + K GN + L G L Y APE+I+ S L D+++ G + Y
Sbjct: 153 LCAKPK---GN--KDYHLQTCCGSLAYAAPELIQG----KSYL---GSEADVWSMGILLY 200
Query: 551 ELLCGEFPFKGQPPESIHLASR*GREAVP 637
L+CG PF +++ G+ VP
Sbjct: 201 VLMCGFLPFDDDNVMALYKKIMRGKYDVP 229
>AK222811-1|BAD96531.1| 651|Homo sapiens maternal embryonic leucine
zipper kinase variant protein.
Length = 651
Score = 76.2 bits (179), Expect = 1e-13
Identities = 58/209 (27%), Positives = 101/209 (48%), Gaps = 1/209 (0%)
Frame = +2
Query: 14 VAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMT 193
VA+K++ L D L K E+ + RH+++ ++ +V C G
Sbjct: 37 VAIKIMDKNTLGSD---LPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGE 93
Query: 194 LYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKN-IFLESGKVVITDFG 370
L+ +I + +D+ + ++ +V +QI + Y+H++G H+DLK +N +F E K+ + DFG
Sbjct: 94 LFDYI-ISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFG 152
Query: 371 LFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWY 550
L + K GN + L G L Y APE+I+ S L D+++ G + Y
Sbjct: 153 LCAKPK---GN--KDYHLQTCCGSLAYAAPELIQG----KSYL---GSEADVWSMGILLY 200
Query: 551 ELLCGEFPFKGQPPESIHLASR*GREAVP 637
L+CG PF +++ G+ VP
Sbjct: 201 VLMCGFLPFDDDNVMALYKKIMRGKYDVP 229
>AK093251-1|BAC04109.1| 514|Homo sapiens protein ( Homo sapiens
cDNA FLJ35932 fis, clone TESTI2011286, weakly similar to
MYOSIN LIGHT CHAIN KINASE (EC 2.7.1.117). ).
Length = 514
Score = 76.2 bits (179), Expect = 1e-13
Identities = 57/191 (29%), Positives = 92/191 (48%), Gaps = 10/191 (5%)
Frame = +2
Query: 59 SLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTAN 238
S + + EV+I + +HE+++ P ++ +V LC+ L I RK F+ N
Sbjct: 155 SAVKLLEREVNILKSVKHEHIIHLEQVFETPKKMYLVMELCEDGEL-KEILDRKGHFSEN 213
Query: 239 KSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLESG----------KVVITDFGLFSVTK 388
++ + Q ++ + YLH I+H+DLK +NI ++S + +TDFGL +V K
Sbjct: 214 ETRWIIQSLASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGL-AVKK 272
Query: 389 LCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGE 568
+ G P Y+APE+I A H +S+ DI++ G V Y LL GE
Sbjct: 273 QSRSEAMLQATCGTP----IYMAPEVISA---H-----DYSQQCDIWSIGVVMYMLLRGE 320
Query: 569 FPFKGQPPESI 601
PF E +
Sbjct: 321 PPFLASSEEKL 331
>AJ303380-1|CAC29064.1| 514|Homo sapiens serine/threonine kinase 33
protein.
Length = 514
Score = 76.2 bits (179), Expect = 1e-13
Identities = 57/191 (29%), Positives = 92/191 (48%), Gaps = 10/191 (5%)
Frame = +2
Query: 59 SLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTAN 238
S + + EV+I + +HE+++ P ++ +V LC+ L I RK F+ N
Sbjct: 155 SAVKLLEREVNILKSVKHEHIIHLEQVFETPKKMYLVMELCEDGEL-KEILDRKGHFSEN 213
Query: 239 KSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLESG----------KVVITDFGLFSVTK 388
++ + Q ++ + YLH I+H+DLK +NI ++S + +TDFGL +V K
Sbjct: 214 ETRWIIQSLASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGL-AVKK 272
Query: 389 LCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGE 568
+ G P Y+APE+I A H +S+ DI++ G V Y LL GE
Sbjct: 273 QSRSEAMLQATCGTP----IYMAPEVISA---H-----DYSQQCDIWSIGVVMYMLLRGE 320
Query: 569 FPFKGQPPESI 601
PF E +
Sbjct: 321 PPFLASSEEKL 331
>AF125532-1|AAF17226.1| 414|Homo sapiens map kinase-interacting
kinase protein.
Length = 414
Score = 76.2 bits (179), Expect = 1e-13
Identities = 52/176 (29%), Positives = 87/176 (49%), Gaps = 5/176 (2%)
Frame = +2
Query: 74 FKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLV 253
F+ +++ H N++ + + R +V +G ++ +HIH R+ F ++ +V
Sbjct: 127 FREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRH-FNELEASVV 185
Query: 254 AQQISQGMGYLHARGIIHKDLKTKNIFLES----GKVVITDFGLFSVTKLCFG-NNARGD 418
Q ++ + +LH +GI H+DLK +NI E V I DF L S KL +
Sbjct: 186 VQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTP 245
Query: 419 SLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQ 586
L P G Y+APE++ A AS+ + K D+++ G + Y LL G PF G+
Sbjct: 246 ELLTPCGSAEYMAPELVEAFSEEASI---YDKRCDLWSLGVILYILLSGYPPFVGR 298
>X73458-1|CAA51837.1| 603|Homo sapiens protein kinase protein.
Length = 603
Score = 75.8 bits (178), Expect = 1e-13
Identities = 56/186 (30%), Positives = 93/186 (50%), Gaps = 1/186 (0%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E+SI R H+++V F G + +V LC+ +L +H R+ T ++ +Q
Sbjct: 101 EISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLL-ELHKRRKALTEPEARYYLRQ 159
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFL-ESGKVVITDFGLFSVTKLCFGNNARGDSLGIPSG 439
I G YLH +IH+DLK N+FL E +V I DFGL TK+ + + G P+
Sbjct: 160 IVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGL--ATKVEYDGERKKTLCGTPN- 216
Query: 440 WLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESIHLASR* 619
Y+APE++ + + H S D+++ G + Y LL G+ PF+ + +L +
Sbjct: 217 ---YIAPEVL-SKKGH-------SFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKK 265
Query: 620 GREAVP 637
++P
Sbjct: 266 NEYSIP 271
>X52479-1|CAA36718.1| 672|Homo sapiens protein ( Human PKC alpha
mRNA for protein kinase C alpha. ).
Length = 672
Score = 75.8 bits (178), Expect = 1e-13
Identities = 52/150 (34%), Positives = 77/150 (51%), Gaps = 1/150 (0%)
Frame = +2
Query: 155 RLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIF 334
RL V G L HI + KF ++V A +IS G+ +LH RGII++DLK N+
Sbjct: 412 RLYFVMEYVNGGDLMYHIQ-QVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVM 470
Query: 335 LES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFS 511
L+S G + I DFG +C + G + G Y+APEII P+
Sbjct: 471 LDSEGHIKIADFG------MCKEHMMDGVTTRTFCGTPDYIAPEII--------AYQPYG 516
Query: 512 KATDIYAFGTVWYELLCGEFPFKGQPPESI 601
K+ D +A+G + YE+L G+ PF G+ + +
Sbjct: 517 KSVDWWAYGVLLYEMLAGQPPFDGEDEDEL 546
>U01038-1|AAA56634.1| 603|Homo sapiens pLK protein.
Length = 603
Score = 75.8 bits (178), Expect = 1e-13
Identities = 56/186 (30%), Positives = 93/186 (50%), Gaps = 1/186 (0%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E+SI R H+++V F G + +V LC+ +L +H R+ T ++ +Q
Sbjct: 101 EISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLL-ELHKRRKALTEPEARYYLRQ 159
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFL-ESGKVVITDFGLFSVTKLCFGNNARGDSLGIPSG 439
I G YLH +IH+DLK N+FL E +V I DFGL TK+ + + G P+
Sbjct: 160 IVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGL--ATKVEYDGERKKTLCGTPN- 216
Query: 440 WLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESIHLASR* 619
Y+APE++ + + H S D+++ G + Y LL G+ PF+ + +L +
Sbjct: 217 ---YIAPEVL-SKKGH-------SFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKK 265
Query: 620 GREAVP 637
++P
Sbjct: 266 NEYSIP 271
>L19559-1|AAA36659.1| 603|Homo sapiens protein kinase protein.
Length = 603
Score = 75.8 bits (178), Expect = 1e-13
Identities = 56/186 (30%), Positives = 93/186 (50%), Gaps = 1/186 (0%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E+SI R H+++V F G + +V LC+ +L +H R+ T ++ +Q
Sbjct: 101 EISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLL-ELHKRRKALTEPEARYYLRQ 159
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFL-ESGKVVITDFGLFSVTKLCFGNNARGDSLGIPSG 439
I G YLH +IH+DLK N+FL E +V I DFGL TK+ + + G P+
Sbjct: 160 IVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGL--ATKVEYDGERKKTLCGTPN- 216
Query: 440 WLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESIHLASR* 619
Y+APE++ + + H S D+++ G + Y LL G+ PF+ + +L +
Sbjct: 217 ---YIAPEVL-SKKGH-------SFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKK 265
Query: 620 GREAVP 637
++P
Sbjct: 266 NEYSIP 271
>BC109274-1|AAI09275.1| 672|Homo sapiens protein kinase C, alpha
protein.
Length = 672
Score = 75.8 bits (178), Expect = 1e-13
Identities = 52/150 (34%), Positives = 77/150 (51%), Gaps = 1/150 (0%)
Frame = +2
Query: 155 RLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIF 334
RL V G L HI + KF ++V A +IS G+ +LH RGII++DLK N+
Sbjct: 412 RLYFVMEYVNGGDLMYHIQ-QVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVM 470
Query: 335 LES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFS 511
L+S G + I DFG +C + G + G Y+APEII P+
Sbjct: 471 LDSEGHIKIADFG------MCKEHMMDGVTTRTFCGTPDYIAPEII--------AYQPYG 516
Query: 512 KATDIYAFGTVWYELLCGEFPFKGQPPESI 601
K+ D +A+G + YE+L G+ PF G+ + +
Sbjct: 517 KSVDWWAYGVLLYEMLAGQPPFDGEDEDEL 546
>BC109273-1|AAI09274.1| 672|Homo sapiens protein kinase C, alpha
protein.
Length = 672
Score = 75.8 bits (178), Expect = 1e-13
Identities = 52/150 (34%), Positives = 77/150 (51%), Gaps = 1/150 (0%)
Frame = +2
Query: 155 RLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIF 334
RL V G L HI + KF ++V A +IS G+ +LH RGII++DLK N+
Sbjct: 412 RLYFVMEYVNGGDLMYHIQ-QVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVM 470
Query: 335 LES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFS 511
L+S G + I DFG +C + G + G Y+APEII P+
Sbjct: 471 LDSEGHIKIADFG------MCKEHMMDGVTTRTFCGTPDYIAPEII--------AYQPYG 516
Query: 512 KATDIYAFGTVWYELLCGEFPFKGQPPESI 601
K+ D +A+G + YE+L G+ PF G+ + +
Sbjct: 517 KSVDWWAYGVLLYEMLAGQPPFDGEDEDEL 546
>BC014846-1|AAH14846.1| 603|Homo sapiens polo-like kinase 1
(Drosophila) protein.
Length = 603
Score = 75.8 bits (178), Expect = 1e-13
Identities = 56/186 (30%), Positives = 93/186 (50%), Gaps = 1/186 (0%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E+SI R H+++V F G + +V LC+ +L +H R+ T ++ +Q
Sbjct: 101 EISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLL-ELHKRRKALTEPEARYYLRQ 159
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFL-ESGKVVITDFGLFSVTKLCFGNNARGDSLGIPSG 439
I G YLH +IH+DLK N+FL E +V I DFGL TK+ + + G P+
Sbjct: 160 IVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGL--ATKVEYDGERKKTLCGTPN- 216
Query: 440 WLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESIHLASR* 619
Y+APE++ + + H S D+++ G + Y LL G+ PF+ + +L +
Sbjct: 217 ---YIAPEVL-SKKGH-------SFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKK 265
Query: 620 GREAVP 637
++P
Sbjct: 266 NEYSIP 271
>BC003002-1|AAH03002.1| 603|Homo sapiens polo-like kinase 1
(Drosophila) protein.
Length = 603
Score = 75.8 bits (178), Expect = 1e-13
Identities = 56/186 (30%), Positives = 93/186 (50%), Gaps = 1/186 (0%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E+SI R H+++V F G + +V LC+ +L +H R+ T ++ +Q
Sbjct: 101 EISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLL-ELHKRRKALTEPEARYYLRQ 159
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFL-ESGKVVITDFGLFSVTKLCFGNNARGDSLGIPSG 439
I G YLH +IH+DLK N+FL E +V I DFGL TK+ + + G P+
Sbjct: 160 IVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGL--ATKVEYDGERKKTLCGTPN- 216
Query: 440 WLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESIHLASR* 619
Y+APE++ + + H S D+++ G + Y LL G+ PF+ + +L +
Sbjct: 217 ---YIAPEVL-SKKGH-------SFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKK 265
Query: 620 GREAVP 637
++P
Sbjct: 266 NEYSIP 271
>BC002369-1|AAH02369.1| 603|Homo sapiens polo-like kinase 1
(Drosophila) protein.
Length = 603
Score = 75.8 bits (178), Expect = 1e-13
Identities = 56/186 (30%), Positives = 93/186 (50%), Gaps = 1/186 (0%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E+SI R H+++V F G + +V LC+ +L +H R+ T ++ +Q
Sbjct: 101 EISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLL-ELHKRRKALTEPEARYYLRQ 159
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFL-ESGKVVITDFGLFSVTKLCFGNNARGDSLGIPSG 439
I G YLH +IH+DLK N+FL E +V I DFGL TK+ + + G P+
Sbjct: 160 IVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGL--ATKVEYDGERKKTLCGTPN- 216
Query: 440 WLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESIHLASR* 619
Y+APE++ + + H S D+++ G + Y LL G+ PF+ + +L +
Sbjct: 217 ---YIAPEVL-SKKGH-------SFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKK 265
Query: 620 GREAVP 637
++P
Sbjct: 266 NEYSIP 271
>AY633609-1|AAV33302.1| 672|Homo sapiens aging-associated gene 6
protein protein.
Length = 672
Score = 75.8 bits (178), Expect = 1e-13
Identities = 52/150 (34%), Positives = 77/150 (51%), Gaps = 1/150 (0%)
Frame = +2
Query: 155 RLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIF 334
RL V G L HI + KF ++V A +IS G+ +LH RGII++DLK N+
Sbjct: 412 RLYFVMEYVNGGDLMYHIQ-QVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVM 470
Query: 335 LES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFS 511
L+S G + I DFG +C + G + G Y+APEII P+
Sbjct: 471 LDSEGHIKIADFG------MCKEHMMDGVTTRTFCGTPDYIAPEII--------AYQPYG 516
Query: 512 KATDIYAFGTVWYELLCGEFPFKGQPPESI 601
K+ D +A+G + YE+L G+ PF G+ + +
Sbjct: 517 KSVDWWAYGVLLYEMLAGQPPFDGEDEDEL 546
>AL133380-4|CAI23046.1| 1036|Homo sapiens mixed lineage kinase 4
(KIAA1804) protein.
Length = 1036
Score = 74.9 bits (176), Expect = 2e-13
Identities = 61/213 (28%), Positives = 97/213 (45%), Gaps = 19/213 (8%)
Frame = +2
Query: 2 WHGA-VAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSL 178
W G VAVK P D + ++ + E +F RH N++ G C++ P L +V
Sbjct: 143 WQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEF 202
Query: 179 CKGMTLYTHIHL-------------RKDKFTANKSVLVAQQISQGMGYLHARG---IIHK 310
+G L + R + + V A QI++GM YLH I+H+
Sbjct: 203 ARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHR 262
Query: 311 DLKTKNIFLESGKVVITDF--GLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRP 484
DLK+ NI L K+ D +T + +G ++APE+I++
Sbjct: 263 DLKSSNILLLE-KIEHDDICNKTLKITDFGLAREWHRTTKMSTAGTYAWMAPEVIKS--- 318
Query: 485 HASLLLPFSKATDIYAFGTVWYELLCGEFPFKG 583
SL FSK +DI+++G + +ELL GE P++G
Sbjct: 319 --SL---FSKGSDIWSYGVLLWELLTGEVPYRG 346
>AL133380-3|CAI23045.1| 570|Homo sapiens mixed lineage kinase 4
(KIAA1804) protein.
Length = 570
Score = 74.9 bits (176), Expect = 2e-13
Identities = 61/213 (28%), Positives = 97/213 (45%), Gaps = 19/213 (8%)
Frame = +2
Query: 2 WHGA-VAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSL 178
W G VAVK P D + ++ + E +F RH N++ G C++ P L +V
Sbjct: 143 WQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEF 202
Query: 179 CKGMTLYTHIHL-------------RKDKFTANKSVLVAQQISQGMGYLHARG---IIHK 310
+G L + R + + V A QI++GM YLH I+H+
Sbjct: 203 ARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHR 262
Query: 311 DLKTKNIFLESGKVVITDF--GLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRP 484
DLK+ NI L K+ D +T + +G ++APE+I++
Sbjct: 263 DLKSSNILLLE-KIEHDDICNKTLKITDFGLAREWHRTTKMSTAGTYAWMAPEVIKS--- 318
Query: 485 HASLLLPFSKATDIYAFGTVWYELLCGEFPFKG 583
SL FSK +DI+++G + +ELL GE P++G
Sbjct: 319 --SL---FSKGSDIWSYGVLLWELLTGEVPYRG 346
>L41816-1|AAA99458.1| 370|Homo sapiens cam kinase I protein.
Length = 370
Score = 74.5 bits (175), Expect = 3e-13
Identities = 50/173 (28%), Positives = 85/173 (49%), Gaps = 4/173 (2%)
Frame = +2
Query: 71 TFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVL 250
+ ++E+++ K +H N+V L ++ L G L+ I + K +T +
Sbjct: 62 SMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRI-VEKGFYTERDASR 120
Query: 251 VAQQISQGMGYLHARGIIHKDLKTKNIFL----ESGKVVITDFGLFSVTKLCFGNNARGD 418
+ Q+ + YLH GI+H+DLK +N+ E K++I+DFGL +K+ +
Sbjct: 121 LIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGL---SKMEDPGSVLST 177
Query: 419 SLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
+ G P Y+APE++ P+SKA D ++ G + Y LLCG PF
Sbjct: 178 ACGTPG----YVAPEVLAQK--------PYSKAVDCWSIGVIAYILLCGYPPF 218
>BT020098-1|AAV38901.1| 367|Homo sapiens serum/glucocorticoid
regulated kinase 2 protein.
Length = 367
Score = 74.5 bits (175), Expect = 3e-13
Identities = 53/166 (31%), Positives = 80/166 (48%), Gaps = 1/166 (0%)
Frame = +2
Query: 92 IFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQ 271
+ + RH LV + P +L V G L+ H+ R+ +F ++ A +++
Sbjct: 87 LLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQ-RERRFLEPRARFYAAEVAS 145
Query: 272 GMGYLHARGIIHKDLKTKNIFLE-SGKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLC 448
+ YLH+ II++DLK +NI L+ G VV+TDFG LC D+ G
Sbjct: 146 AIDYLHSLNIIYRDLKPENILLDCQGHVVLTDFG------LCKEGVEPEDTTSTFCGTPE 199
Query: 449 YLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQ 586
YLAPE++R P+ +A D + G V YE+L G PF Q
Sbjct: 200 YLAPEVLRK--------EPYDRAVDWWCLGAVLYEMLHGLPPFYSQ 237
>BC106755-1|AAI06756.1| 370|Homo sapiens
calcium/calmodulin-dependent protein kinase I protein.
Length = 370
Score = 74.5 bits (175), Expect = 3e-13
Identities = 50/173 (28%), Positives = 85/173 (49%), Gaps = 4/173 (2%)
Frame = +2
Query: 71 TFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVL 250
+ ++E+++ K +H N+V L ++ L G L+ I + K +T +
Sbjct: 62 SMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRI-VEKGFYTERDASR 120
Query: 251 VAQQISQGMGYLHARGIIHKDLKTKNIFL----ESGKVVITDFGLFSVTKLCFGNNARGD 418
+ Q+ + YLH GI+H+DLK +N+ E K++I+DFGL +K+ +
Sbjct: 121 LIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGL---SKMEDPGSVLST 177
Query: 419 SLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
+ G P Y+APE++ P+SKA D ++ G + Y LLCG PF
Sbjct: 178 ACGTPG----YVAPEVLAQK--------PYSKAVDCWSIGVIAYILLCGYPPF 218
>BC106754-1|AAI06755.1| 370|Homo sapiens
calcium/calmodulin-dependent protein kinase I protein.
Length = 370
Score = 74.5 bits (175), Expect = 3e-13
Identities = 50/173 (28%), Positives = 85/173 (49%), Gaps = 4/173 (2%)
Frame = +2
Query: 71 TFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVL 250
+ ++E+++ K +H N+V L ++ L G L+ I + K +T +
Sbjct: 62 SMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRI-VEKGFYTERDASR 120
Query: 251 VAQQISQGMGYLHARGIIHKDLKTKNIFL----ESGKVVITDFGLFSVTKLCFGNNARGD 418
+ Q+ + YLH GI+H+DLK +N+ E K++I+DFGL +K+ +
Sbjct: 121 LIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGL---SKMEDPGSVLST 177
Query: 419 SLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
+ G P Y+APE++ P+SKA D ++ G + Y LLCG PF
Sbjct: 178 ACGTPG----YVAPEVLAQK--------PYSKAVDCWSIGVIAYILLCGYPPF 218
>X75932-1|CAA53536.1| 603|Homo sapiens Serine/Threonine protein
kinase protein.
Length = 603
Score = 74.1 bits (174), Expect = 4e-13
Identities = 56/186 (30%), Positives = 92/186 (49%), Gaps = 1/186 (0%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E+SI R H+++V F G + +V LC+ +L H R+ T ++ +Q
Sbjct: 101 EISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLEP-HKRRKALTEPEARYYLRQ 159
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFL-ESGKVVITDFGLFSVTKLCFGNNARGDSLGIPSG 439
I G YLH +IH+DLK N+FL E +V I DFGL TK+ + + G P+
Sbjct: 160 IVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGL--ATKVEYDGERKKTLCGTPN- 216
Query: 440 WLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESIHLASR* 619
Y+APE++ + + H S D+++ G + Y LL G+ PF+ + +L +
Sbjct: 217 ---YIAPEVL-SKKEH-------SFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKK 265
Query: 620 GREAVP 637
++P
Sbjct: 266 NEYSIP 271
>AF045458-1|AAC32326.1| 1050|Homo sapiens serine/threonine kinase
ULK1 protein.
Length = 1050
Score = 74.1 bits (174), Expect = 4e-13
Identities = 56/211 (26%), Positives = 98/211 (46%), Gaps = 3/211 (1%)
Frame = +2
Query: 14 VAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMT 193
VAVK ++ L+ +LL E+ I ++ +HEN+V + +V C G
Sbjct: 43 VAVKCINKKNLAKSQTLLGK---EIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGD 99
Query: 194 LYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLE--SGKVVITDF 367
L ++H + + + L QQI+ M LH++GIIH+DLK +NI L +G+ +
Sbjct: 100 LADYLHAMRT-LSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNS 158
Query: 368 GLFSVTKLCFGNNARGDSLGIP-SGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTV 544
+ F + + + G Y+APE+I + H + D+++ GT+
Sbjct: 159 IRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVI--MSQH------YDGKADLWSIGTI 210
Query: 545 WYELLCGEFPFKGQPPESIHLASR*GREAVP 637
Y+ L G+ PF+ P+ + L + VP
Sbjct: 211 VYQCLTGKAPFQASSPQDLRLFYEKNKTLVP 241
>AB018265-1|BAA34442.2| 1066|Homo sapiens KIAA0722 protein protein.
Length = 1066
Score = 74.1 bits (174), Expect = 4e-13
Identities = 56/211 (26%), Positives = 98/211 (46%), Gaps = 3/211 (1%)
Frame = +2
Query: 14 VAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMT 193
VAVK ++ L+ +LL E+ I ++ +HEN+V + +V C G
Sbjct: 59 VAVKCINKKNLAKSQTLLGK---EIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGD 115
Query: 194 LYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLE--SGKVVITDF 367
L ++H + + + L QQI+ M LH++GIIH+DLK +NI L +G+ +
Sbjct: 116 LADYLHAMRT-LSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNS 174
Query: 368 GLFSVTKLCFGNNARGDSLGIP-SGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTV 544
+ F + + + G Y+APE+I + H + D+++ GT+
Sbjct: 175 IRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVI--MSQH------YDGKADLWSIGTI 226
Query: 545 WYELLCGEFPFKGQPPESIHLASR*GREAVP 637
Y+ L G+ PF+ P+ + L + VP
Sbjct: 227 VYQCLTGKAPFQASSPQDLRLFYEKNKTLVP 257
>U63721-3|AAC13886.1| 633|Homo sapiens LIM-kinase protein.
Length = 633
Score = 73.7 bits (173), Expect = 5e-13
Identities = 39/102 (38%), Positives = 55/102 (53%), Gaps = 1/102 (0%)
Frame = +2
Query: 71 TFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVL 250
TF EV + R H N++ F+G K RL +T KG TL I ++ ++ V
Sbjct: 366 TFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVS 425
Query: 251 VAQQISQGMGYLHARGIIHKDLKTKNIFLESGK-VVITDFGL 373
A+ I+ GM YLH+ IIH+DL + N + K VV+ DFGL
Sbjct: 426 FAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGL 467
>U63721-2|AAC13885.1| 647|Homo sapiens LIM-kinase protein.
Length = 647
Score = 73.7 bits (173), Expect = 5e-13
Identities = 39/102 (38%), Positives = 55/102 (53%), Gaps = 1/102 (0%)
Frame = +2
Query: 71 TFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVL 250
TF EV + R H N++ F+G K RL +T KG TL I ++ ++ V
Sbjct: 380 TFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVS 439
Query: 251 VAQQISQGMGYLHARGIIHKDLKTKNIFLESGK-VVITDFGL 373
A+ I+ GM YLH+ IIH+DL + N + K VV+ DFGL
Sbjct: 440 FAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGL 481
>U62293-2|AAB17546.1| 633|Homo sapiens alternatively spliced
LIM-kinase1 protein.
Length = 633
Score = 73.7 bits (173), Expect = 5e-13
Identities = 39/102 (38%), Positives = 55/102 (53%), Gaps = 1/102 (0%)
Frame = +2
Query: 71 TFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVL 250
TF EV + R H N++ F+G K RL +T KG TL I ++ ++ V
Sbjct: 366 TFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVS 425
Query: 251 VAQQISQGMGYLHARGIIHKDLKTKNIFLESGK-VVITDFGL 373
A+ I+ GM YLH+ IIH+DL + N + K VV+ DFGL
Sbjct: 426 FAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGL 467
>U62293-1|AAB17545.1| 647|Homo sapiens LIM-kinase1 protein.
Length = 647
Score = 73.7 bits (173), Expect = 5e-13
Identities = 39/102 (38%), Positives = 55/102 (53%), Gaps = 1/102 (0%)
Frame = +2
Query: 71 TFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVL 250
TF EV + R H N++ F+G K RL +T KG TL I ++ ++ V
Sbjct: 380 TFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVS 439
Query: 251 VAQQISQGMGYLHARGIIHKDLKTKNIFLESGK-VVITDFGL 373
A+ I+ GM YLH+ IIH+DL + N + K VV+ DFGL
Sbjct: 440 FAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGL 481
>D26309-1|BAA05371.1| 647|Homo sapiens LIM kinase protein.
Length = 647
Score = 73.7 bits (173), Expect = 5e-13
Identities = 39/102 (38%), Positives = 55/102 (53%), Gaps = 1/102 (0%)
Frame = +2
Query: 71 TFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVL 250
TF EV + R H N++ F+G K RL +T KG TL I ++ ++ V
Sbjct: 380 TFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVS 439
Query: 251 VAQQISQGMGYLHARGIIHKDLKTKNIFLESGK-VVITDFGL 373
A+ I+ GM YLH+ IIH+DL + N + K VV+ DFGL
Sbjct: 440 FAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGL 481
>CR536581-1|CAG38818.1| 429|Homo sapiens SGKL protein.
Length = 429
Score = 73.7 bits (173), Expect = 5e-13
Identities = 53/163 (32%), Positives = 79/163 (48%), Gaps = 1/163 (0%)
Frame = +2
Query: 92 IFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQ 271
+ + +H LV + +L V G L+ H+ R+ F +++ A +I+
Sbjct: 147 LLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQ-RERSFPEHRARFYAAEIAS 205
Query: 272 GMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLC 448
+GYLH+ I+++DLK +NI L+S G VV+TDFG LC A D+ G
Sbjct: 206 ALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFG------LCKEGIAISDTTTTFCGTPE 259
Query: 449 YLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
YLAPE+IR P+ D + G V YE+L G PF
Sbjct: 260 YLAPEVIRK--------QPYDNTVDWWCLGAVLYEMLYGLPPF 294
>BC015326-1|AAH15326.1| 496|Homo sapiens serum/glucocorticoid
regulated kinase family, member 3 protein.
Length = 496
Score = 73.7 bits (173), Expect = 5e-13
Identities = 53/163 (32%), Positives = 79/163 (48%), Gaps = 1/163 (0%)
Frame = +2
Query: 92 IFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQ 271
+ + +H LV + +L V G L+ H+ R+ F +++ A +I+
Sbjct: 214 LLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQ-RERSFPEHRARFYAAEIAS 272
Query: 272 GMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLC 448
+GYLH+ I+++DLK +NI L+S G VV+TDFG LC A D+ G
Sbjct: 273 ALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFG------LCKEGIAISDTTTTFCGTPE 326
Query: 449 YLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
YLAPE+IR P+ D + G V YE+L G PF
Sbjct: 327 YLAPEVIRK--------QPYDNTVDWWCLGAVLYEMLYGLPPF 361
>AK223523-1|BAD97243.1| 496|Homo sapiens serum/glucocorticoid
regulated kinase-like isoform 1 variant protein.
Length = 496
Score = 73.7 bits (173), Expect = 5e-13
Identities = 53/163 (32%), Positives = 79/163 (48%), Gaps = 1/163 (0%)
Frame = +2
Query: 92 IFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQ 271
+ + +H LV + +L V G L+ H+ R+ F +++ A +I+
Sbjct: 214 LLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQ-RERSFPEHRARFYAAEIAS 272
Query: 272 GMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLC 448
+GYLH+ I+++DLK +NI L+S G VV+TDFG LC A D+ G
Sbjct: 273 ALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFG------LCKEGIAISDTTTTFCGTPE 326
Query: 449 YLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
YLAPE+IR P+ D + G V YE+L G PF
Sbjct: 327 YLAPEVIRK--------QPYDNTVDWWCLGAVLYEMLYGLPPF 361
>AF169035-1|AAF12758.1| 429|Homo sapiens protein kinase protein.
Length = 429
Score = 73.7 bits (173), Expect = 5e-13
Identities = 53/163 (32%), Positives = 79/163 (48%), Gaps = 1/163 (0%)
Frame = +2
Query: 92 IFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQ 271
+ + +H LV + +L V G L+ H+ R+ F +++ A +I+
Sbjct: 147 LLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQ-RERSFPEHRARFYAAEIAS 205
Query: 272 GMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLC 448
+GYLH+ I+++DLK +NI L+S G VV+TDFG LC A D+ G
Sbjct: 206 ALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFG------LCKEGIAISDTTTTFCGTPE 259
Query: 449 YLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
YLAPE+IR P+ D + G V YE+L G PF
Sbjct: 260 YLAPEVIRK--------QPYDNTVDWWCLGAVLYEMLYGLPPF 294
>AC005057-3|AAS07438.1| 596|Homo sapiens unknown protein.
Length = 596
Score = 73.7 bits (173), Expect = 5e-13
Identities = 39/102 (38%), Positives = 55/102 (53%), Gaps = 1/102 (0%)
Frame = +2
Query: 71 TFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVL 250
TF EV + R H N++ F+G K RL +T KG TL I ++ ++ V
Sbjct: 329 TFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVS 388
Query: 251 VAQQISQGMGYLHARGIIHKDLKTKNIFLESGK-VVITDFGL 373
A+ I+ GM YLH+ IIH+DL + N + K VV+ DFGL
Sbjct: 389 FAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGL 430
>L13738-1|AAA53570.2| 1036|Homo sapiens activated p21cdc42Hs kinase
protein.
Length = 1036
Score = 72.9 bits (171), Expect = 9e-13
Identities = 58/193 (30%), Positives = 89/193 (46%), Gaps = 2/193 (1%)
Frame = +2
Query: 11 AVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGM 190
+VAVK L LS ++ D F EV+ H NL+ G + PP + +VT L
Sbjct: 154 SVAVKCLKPDVLSQPEAM-DDFIREVNAMHSLDHRNLIRLYGVVLTPP-MKMVTELAPLG 211
Query: 191 TLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLESGKVV-ITDF 367
+L + + F A Q+++GMGYL ++ IH+DL +N+ L + +V I DF
Sbjct: 212 SLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDF 271
Query: 368 GLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFG-TV 544
GL + + +P W C APE ++ FS A+D + FG T+
Sbjct: 272 GLMRALPQNDDHYVMQEHRKVPFAW-C--APESLKT--------RTFSHASDTWMFGVTL 320
Query: 545 WYELLCGEFPFKG 583
W G+ P+ G
Sbjct: 321 WEMFTYGQEPWIG 333
>BC028164-1|AAH28164.1| 528|Homo sapiens TNK2 protein protein.
Length = 528
Score = 72.9 bits (171), Expect = 9e-13
Identities = 58/193 (30%), Positives = 89/193 (46%), Gaps = 2/193 (1%)
Frame = +2
Query: 11 AVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGM 190
+VAVK L LS ++ D F EV+ H NL+ G + PP + +VT L
Sbjct: 154 SVAVKCLKPDVLSQPEAM-DDFIREVNAMHSLDHRNLIRLYGVVLTPP-MKMVTELAPLG 211
Query: 191 TLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLESGKVV-ITDF 367
+L + + F A Q+++GMGYL ++ IH+DL +N+ L + +V I DF
Sbjct: 212 SLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDF 271
Query: 368 GLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFG-TV 544
GL + + +P W C APE ++ FS A+D + FG T+
Sbjct: 272 GLMRALPQNDDHYVMQEHRKVPFAW-C--APESLKT--------RTFSHASDTWMFGVTL 320
Query: 545 WYELLCGEFPFKG 583
W G+ P+ G
Sbjct: 321 WEMFTYGQEPWIG 333
>AK131539-1|BAD18675.1| 1086|Homo sapiens protein ( Homo sapiens
cDNA FLJ16772 fis, clone BRAWH3043827, highly similar
to Homo sapiens activated p21cdc42Hs kinase (ACK1). ).
Length = 1086
Score = 72.9 bits (171), Expect = 9e-13
Identities = 58/193 (30%), Positives = 89/193 (46%), Gaps = 2/193 (1%)
Frame = +2
Query: 11 AVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGM 190
+VAVK L LS ++ D F EV+ H NL+ G + PP + +VT L
Sbjct: 217 SVAVKCLKPDVLSQPEAM-DDFIREVNAMHSLDHRNLIRLYGVVLTPP-MKMVTELAPLG 274
Query: 191 TLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLESGKVV-ITDF 367
+L + + F A Q+++GMGYL ++ IH+DL +N+ L + +V I DF
Sbjct: 275 SLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDF 334
Query: 368 GLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFG-TV 544
GL + + +P W C APE ++ FS A+D + FG T+
Sbjct: 335 GLMRALPQNDDHYVMQEHRKVPFAW-C--APESLKT--------RTFSHASDTWMFGVTL 383
Query: 545 WYELLCGEFPFKG 583
W G+ P+ G
Sbjct: 384 WEMFTYGQEPWIG 396
>AB209338-1|BAD92575.1| 400|Homo sapiens Hypothetical protein
FLJ16772 variant protein.
Length = 400
Score = 72.9 bits (171), Expect = 9e-13
Identities = 58/193 (30%), Positives = 89/193 (46%), Gaps = 2/193 (1%)
Frame = +2
Query: 11 AVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGM 190
+VAVK L LS ++ D F EV+ H NL+ G + PP + +VT L
Sbjct: 30 SVAVKCLKPDVLSQPEAM-DDFIREVNAMHSLDHRNLIRLYGVVLTPP-MKMVTELAPLG 87
Query: 191 TLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLESGKVV-ITDF 367
+L + + F A Q+++GMGYL ++ IH+DL +N+ L + +V I DF
Sbjct: 88 SLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDF 147
Query: 368 GLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFG-TV 544
GL + + +P W C APE ++ FS A+D + FG T+
Sbjct: 148 GLMRALPQNDDHYVMQEHRKVPFAW-C--APESLKT--------RTFSHASDTWMFGVTL 196
Query: 545 WYELLCGEFPFKG 583
W G+ P+ G
Sbjct: 197 WEMFTYGQEPWIG 209
>AB183427-1|BAF73615.1| 619|Homo sapiens maternal embryonic leucine
zipper kinase v2 protein.
Length = 619
Score = 72.9 bits (171), Expect = 9e-13
Identities = 53/192 (27%), Positives = 93/192 (48%), Gaps = 1/192 (0%)
Frame = +2
Query: 65 LDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKS 244
L K E+ + RH+++ ++ +V C G L+ +I + +D+ + ++
Sbjct: 19 LPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYI-ISQDRLSEEET 77
Query: 245 VLVAQQISQGMGYLHARGIIHKDLKTKN-IFLESGKVVITDFGLFSVTKLCFGNNARGDS 421
+V +QI + Y+H++G H+DLK +N +F E K+ + DFGL + K GN +
Sbjct: 78 RVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPK---GN--KDYH 132
Query: 422 LGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESI 601
L G L Y APE+I+ S L D+++ G + Y L+CG PF ++
Sbjct: 133 LQTCCGSLAYAAPELIQG----KSYL---GSEADVWSMGILLYVLMCGFLPFDDDNVMAL 185
Query: 602 HLASR*GREAVP 637
+ G+ VP
Sbjct: 186 YKKIMRGKYDVP 197
>X07109-1|CAA30130.1| 673|Homo sapiens protein ( Human mRNA for
protein kinase C (PKC) type beta II. ).
Length = 673
Score = 72.5 bits (170), Expect = 1e-12
Identities = 50/150 (33%), Positives = 77/150 (51%), Gaps = 1/150 (0%)
Frame = +2
Query: 155 RLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIF 334
RL V G L HI + +F +V A +I+ G+ +L ++GII++DLK N+
Sbjct: 415 RLYFVMEYVNGGDLMYHIQ-QVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVM 473
Query: 335 LES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFS 511
L+S G + I DFG+ C N G + G Y+APEII P+
Sbjct: 474 LDSEGHIKIADFGM------CKENIWDGVTTKTFCGTPDYIAPEIIA--------YQPYG 519
Query: 512 KATDIYAFGTVWYELLCGEFPFKGQPPESI 601
K+ D +AFG + YE+L G+ PF+G+ + +
Sbjct: 520 KSVDWWAFGVLLYEMLAGQAPFEGEDEDEL 549
>X06318-1|CAA29634.1| 671|Homo sapiens protein ( Human mRNA for
protein kinase C (PKC) type beta I. ).
Length = 671
Score = 72.5 bits (170), Expect = 1e-12
Identities = 50/150 (33%), Positives = 77/150 (51%), Gaps = 1/150 (0%)
Frame = +2
Query: 155 RLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIF 334
RL V G L HI + +F +V A +I+ G+ +L ++GII++DLK N+
Sbjct: 415 RLYFVMEYVNGGDLMYHIQ-QVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVM 473
Query: 335 LES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFS 511
L+S G + I DFG+ C N G + G Y+APEII P+
Sbjct: 474 LDSEGHIKIADFGM------CKENIWDGVTTKTFCGTPDYIAPEIIA--------YQPYG 519
Query: 512 KATDIYAFGTVWYELLCGEFPFKGQPPESI 601
K+ D +AFG + YE+L G+ PF+G+ + +
Sbjct: 520 KSVDWWAFGVLLYEMLAGQAPFEGEDEDEL 549
>M13975-1|AAA60095.1| 673|Homo sapiens protein kinase C beta-II
type protein.
Length = 673
Score = 72.5 bits (170), Expect = 1e-12
Identities = 50/150 (33%), Positives = 77/150 (51%), Gaps = 1/150 (0%)
Frame = +2
Query: 155 RLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIF 334
RL V G L HI + +F +V A +I+ G+ +L ++GII++DLK N+
Sbjct: 415 RLYFVMEYVNGGDLMYHIQ-QVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVM 473
Query: 335 LES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFS 511
L+S G + I DFG+ C N G + G Y+APEII P+
Sbjct: 474 LDSEGHIKIADFGM------CKENIWDGVTTKTFCGTPDYIAPEIIA--------YQPYG 519
Query: 512 KATDIYAFGTVWYELLCGEFPFKGQPPESI 601
K+ D +AFG + YE+L G+ PF+G+ + +
Sbjct: 520 KSVDWWAFGVLLYEMLAGQAPFEGEDEDEL 549
>BC036472-1|AAH36472.1| 673|Homo sapiens protein kinase C, beta 1
protein.
Length = 673
Score = 72.5 bits (170), Expect = 1e-12
Identities = 50/150 (33%), Positives = 77/150 (51%), Gaps = 1/150 (0%)
Frame = +2
Query: 155 RLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIF 334
RL V G L HI + +F +V A +I+ G+ +L ++GII++DLK N+
Sbjct: 415 RLYFVMEYVNGGDLMYHIQ-QVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVM 473
Query: 335 LES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFS 511
L+S G + I DFG+ C N G + G Y+APEII P+
Sbjct: 474 LDSEGHIKIADFGM------CKENIWDGVTTKTFCGTPDYIAPEIIA--------YQPYG 519
Query: 512 KATDIYAFGTVWYELLCGEFPFKGQPPESI 601
K+ D +AFG + YE+L G+ PF+G+ + +
Sbjct: 520 KSVDWWAFGVLLYEMLAGQAPFEGEDEDEL 549
>AF085233-1|AAF27051.2| 496|Homo sapiens SGK-like protein SGKL
protein.
Length = 496
Score = 72.5 bits (170), Expect = 1e-12
Identities = 52/163 (31%), Positives = 79/163 (48%), Gaps = 1/163 (0%)
Frame = +2
Query: 92 IFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQ 271
+ + +H LV + +L V G L+ H+ R+ F +++ A +I+
Sbjct: 214 LLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQ-RERSFPEHRARFYAAEIAS 272
Query: 272 GMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLC 448
+GYLH+ I+++DLK +NI ++S G VV+TDFG LC A D+ G
Sbjct: 273 ALGYLHSIKIVYRDLKPENILVDSVGHVVLTDFG------LCKEGIAISDTTTTFCGTPE 326
Query: 449 YLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
YLAPE+IR P+ D + G V YE+L G PF
Sbjct: 327 YLAPEVIRK--------QPYDNTVDWWCLGAVLYEMLYGLPPF 361
>AC002299-2|AAB97934.1| 496|Homo sapiens Protein kinase C beta (5'
partial) splice form_ protein.
Length = 496
Score = 72.5 bits (170), Expect = 1e-12
Identities = 50/150 (33%), Positives = 77/150 (51%), Gaps = 1/150 (0%)
Frame = +2
Query: 155 RLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIF 334
RL V G L HI + +F +V A +I+ G+ +L ++GII++DLK N+
Sbjct: 238 RLYFVMEYVNGGDLMYHIQ-QVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVM 296
Query: 335 LES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFS 511
L+S G + I DFG+ C N G + G Y+APEII P+
Sbjct: 297 LDSEGHIKIADFGM------CKENIWDGVTTKTFCGTPDYIAPEIIA--------YQPYG 342
Query: 512 KATDIYAFGTVWYELLCGEFPFKGQPPESI 601
K+ D +AFG + YE+L G+ PF+G+ + +
Sbjct: 343 KSVDWWAFGVLLYEMLAGQAPFEGEDEDEL 372
>AC002299-1|AAB97933.1| 494|Homo sapiens Protein kinase C beta (5'
partial) splice form_1 protein.
Length = 494
Score = 72.5 bits (170), Expect = 1e-12
Identities = 50/150 (33%), Positives = 77/150 (51%), Gaps = 1/150 (0%)
Frame = +2
Query: 155 RLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIF 334
RL V G L HI + +F +V A +I+ G+ +L ++GII++DLK N+
Sbjct: 238 RLYFVMEYVNGGDLMYHIQ-QVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVM 296
Query: 335 LES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFS 511
L+S G + I DFG+ C N G + G Y+APEII P+
Sbjct: 297 LDSEGHIKIADFGM------CKENIWDGVTTKTFCGTPDYIAPEIIA--------YQPYG 342
Query: 512 KATDIYAFGTVWYELLCGEFPFKGQPPESI 601
K+ D +AFG + YE+L G+ PF+G+ + +
Sbjct: 343 KSVDWWAFGVLLYEMLAGQAPFEGEDEDEL 372
>L07861-1|AAA03175.1| 676|Homo sapiens protein kinase C-delta 13
protein.
Length = 676
Score = 72.1 bits (169), Expect = 2e-12
Identities = 46/149 (30%), Positives = 76/149 (51%), Gaps = 1/149 (0%)
Frame = +2
Query: 158 LAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL 337
L V G L HI K +F ++ A +I G+ +LH++GII++DLK N+ L
Sbjct: 423 LFFVMEFLNGGDLMYHIQ-DKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLL 481
Query: 338 E-SGKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSK 514
+ G + I DFG+ + FG + G P Y+APEI++ L+ ++
Sbjct: 482 DRDGHIKIADFGM--CKENIFGESRASTFCGTPD----YIAPEILQGLK--------YTF 527
Query: 515 ATDIYAFGTVWYELLCGEFPFKGQPPESI 601
+ D ++FG + YE+L G+ PF G + +
Sbjct: 528 SVDWWSFGVLLYEMLIGQSPFHGDDEDEL 556
>L07860-1|AAA03176.1| 676|Homo sapiens protein kinase C-delta 13
protein.
Length = 676
Score = 72.1 bits (169), Expect = 2e-12
Identities = 46/149 (30%), Positives = 76/149 (51%), Gaps = 1/149 (0%)
Frame = +2
Query: 158 LAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL 337
L V G L HI K +F ++ A +I G+ +LH++GII++DLK N+ L
Sbjct: 423 LFFVMEFLNGGDLMYHIQ-DKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLL 481
Query: 338 E-SGKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSK 514
+ G + I DFG+ + FG + G P Y+APEI++ L+ ++
Sbjct: 482 DRDGHIKIADFGM--CKENIFGESRASTFCGTPD----YIAPEILQGLK--------YTF 527
Query: 515 ATDIYAFGTVWYELLCGEFPFKGQPPESI 601
+ D ++FG + YE+L G+ PF G + +
Sbjct: 528 SVDWWSFGVLLYEMLIGQSPFHGDDEDEL 556
>D10495-1|BAA01381.1| 626|Homo sapiens protein kinase C delta-type
protein.
Length = 626
Score = 72.1 bits (169), Expect = 2e-12
Identities = 46/149 (30%), Positives = 76/149 (51%), Gaps = 1/149 (0%)
Frame = +2
Query: 158 LAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL 337
L V G L HI K +F ++ A +I G+ +LH++GII++DLK N+ L
Sbjct: 373 LFFVMEFLNGGDLMYHIQ-DKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLL 431
Query: 338 E-SGKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSK 514
+ G + I DFG+ + FG + G P Y+APEI++ L+ ++
Sbjct: 432 DRDGHIKIADFGM--CKENIFGESRASTFCGTPD----YIAPEILQGLK--------YTF 477
Query: 515 ATDIYAFGTVWYELLCGEFPFKGQPPESI 601
+ D ++FG + YE+L G+ PF G + +
Sbjct: 478 SVDWWSFGVLLYEMLIGQSPFHGDDEDEL 506
>BC043350-1|AAH43350.1| 676|Homo sapiens protein kinase C, delta
protein.
Length = 676
Score = 72.1 bits (169), Expect = 2e-12
Identities = 46/149 (30%), Positives = 76/149 (51%), Gaps = 1/149 (0%)
Frame = +2
Query: 158 LAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL 337
L V G L HI K +F ++ A +I G+ +LH++GII++DLK N+ L
Sbjct: 423 LFFVMEFLNGGDLMYHIQ-DKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLL 481
Query: 338 E-SGKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSK 514
+ G + I DFG+ + FG + G P Y+APEI++ L+ ++
Sbjct: 482 DRDGHIKIADFGM--CKENIFGESRASTFCGTPD----YIAPEILQGLK--------YTF 527
Query: 515 ATDIYAFGTVWYELLCGEFPFKGQPPESI 601
+ D ++FG + YE+L G+ PF G + +
Sbjct: 528 SVDWWSFGVLLYEMLIGQSPFHGDDEDEL 556
>BC034988-1|AAH34988.1| 1036|Homo sapiens ULK2 protein protein.
Length = 1036
Score = 71.7 bits (168), Expect = 2e-12
Identities = 61/218 (27%), Positives = 98/218 (44%), Gaps = 10/218 (4%)
Frame = +2
Query: 14 VAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMT 193
VA+K ++ LS LL E+ I ++ +HEN+V P + +V C G
Sbjct: 36 VAIKSINKKNLSKSQILLGK---EIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGD 92
Query: 194 LYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLE---------SG 346
L ++ K + + + QI+ M LH++GIIH+DLK +NI L SG
Sbjct: 93 LADYLQA-KGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSG 151
Query: 347 -KVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATD 523
++ I DFG + N G P Y+APE+I + H + D
Sbjct: 152 IRIKIADFGF---ARYLHSNMMAATLCGSP----MYMAPEVI--MSQH------YDAKAD 196
Query: 524 IYAFGTVWYELLCGEFPFKGQPPESIHLASR*GREAVP 637
+++ GTV Y+ L G+ PF+ P+ + + R +P
Sbjct: 197 LWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMP 234
>AK098831-1|BAC05426.1| 439|Homo sapiens protein ( Homo sapiens
cDNA FLJ25965 fis, clone TST04647. ).
Length = 439
Score = 71.7 bits (168), Expect = 2e-12
Identities = 32/57 (56%), Positives = 41/57 (71%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVT 172
WHG VA++L+ + D+ L FK EV +R+TRHEN+VLFMGACM PP LAI+T
Sbjct: 382 WHGEVAIRLIDIE--RDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIIT 436
>AB014523-1|BAA31598.2| 1100|Homo sapiens KIAA0623 protein protein.
Length = 1100
Score = 71.7 bits (168), Expect = 2e-12
Identities = 61/218 (27%), Positives = 98/218 (44%), Gaps = 10/218 (4%)
Frame = +2
Query: 14 VAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMT 193
VA+K ++ LS LL E+ I ++ +HEN+V P + +V C G
Sbjct: 100 VAIKSINKKNLSKSQILLGK---EIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGD 156
Query: 194 LYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLE---------SG 346
L ++ K + + + QI+ M LH++GIIH+DLK +NI L SG
Sbjct: 157 LADYLQA-KGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSG 215
Query: 347 -KVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATD 523
++ I DFG + N G P Y+APE+I + H + D
Sbjct: 216 IRIKIADFGF---ARYLHSNMMAATLCGSP----MYMAPEVI--MSQH------YDAKAD 260
Query: 524 IYAFGTVWYELLCGEFPFKGQPPESIHLASR*GREAVP 637
+++ GTV Y+ L G+ PF+ P+ + + R +P
Sbjct: 261 LWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMP 298
>Z98049-1|CAI20579.1| 733|Homo sapiens ribosomal protein S6 kinase,
90kDa, polypeptide 2 protein.
Length = 733
Score = 71.3 bits (167), Expect = 3e-12
Identities = 50/171 (29%), Positives = 87/171 (50%), Gaps = 1/171 (0%)
Frame = +2
Query: 77 KHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVA 256
K E I + H +V A +L ++ +G L+T + ++ FT
Sbjct: 107 KMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLS-KEVMFTEEDVKFYL 165
Query: 257 QQISQGMGYLHARGIIHKDLKTKNIFL-ESGKVVITDFGLFSVTKLCFGNNARGDSLGIP 433
+++ + +LH+ GII++DLK +NI L E G + ITDFGL +K ++ R S
Sbjct: 166 AELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGL---SKEAIDHDKRAYSF--- 219
Query: 434 SGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQ 586
G + Y+APE++ R H +++ D ++FG + +E+L G PF+G+
Sbjct: 220 CGTIEYMAPEVVNR-RGH-------TQSADWWSFGVLMFEMLTGSLPFQGK 262
Score = 56.4 bits (130), Expect = 8e-08
Identities = 51/187 (27%), Positives = 85/187 (45%), Gaps = 5/187 (2%)
Frame = +2
Query: 53 DGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFT 232
D S D + + R +H N++ + +V L +G L I LR+ F+
Sbjct: 447 DKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRI-LRQRYFS 505
Query: 233 ANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL--ESG---KVVITDFGLFSVTKLCF 397
++ V I++ M YLH++G++H+DLK NI ESG + + DFG +L
Sbjct: 506 EREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGF--AKQLRA 563
Query: 398 GNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
GN L P ++APE+++ + A DI++ G + Y +L G PF
Sbjct: 564 GNGL----LMTPCYTANFVAPEVLKR--------QGYDAACDIWSLGILLYTMLAGFTPF 611
Query: 578 KGQPPES 598
P ++
Sbjct: 612 ANGPDDT 618
>X85106-1|CAA59427.1| 733|Homo sapiens ribosomal S6 kinase protein.
Length = 733
Score = 71.3 bits (167), Expect = 3e-12
Identities = 50/171 (29%), Positives = 87/171 (50%), Gaps = 1/171 (0%)
Frame = +2
Query: 77 KHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVA 256
K E I + H +V A +L ++ +G L+T + ++ FT
Sbjct: 107 KMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLS-KEVMFTEEDVKFYL 165
Query: 257 QQISQGMGYLHARGIIHKDLKTKNIFL-ESGKVVITDFGLFSVTKLCFGNNARGDSLGIP 433
+++ + +LH+ GII++DLK +NI L E G + ITDFGL +K ++ R S
Sbjct: 166 AELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGL---SKEAIDHDKRAYSF--- 219
Query: 434 SGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQ 586
G + Y+APE++ R H +++ D ++FG + +E+L G PF+G+
Sbjct: 220 CGTIEYMAPEVVNR-RGH-------TQSADWWSFGVLMFEMLTGSLPFQGK 262
Score = 56.4 bits (130), Expect = 8e-08
Identities = 51/187 (27%), Positives = 85/187 (45%), Gaps = 5/187 (2%)
Frame = +2
Query: 53 DGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFT 232
D S D + + R +H N++ + +V L +G L I LR+ F+
Sbjct: 447 DKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRI-LRQRYFS 505
Query: 233 ANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL--ESG---KVVITDFGLFSVTKLCF 397
++ V I++ M YLH++G++H+DLK NI ESG + + DFG +L
Sbjct: 506 EREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGF--AKQLRA 563
Query: 398 GNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
GN L P ++APE+++ + A DI++ G + Y +L G PF
Sbjct: 564 GNGL----LMTPCYTANFVAPEVLKR--------QGYDAACDIWSLGILLYTMLAGFTPF 611
Query: 578 KGQPPES 598
P ++
Sbjct: 612 ANGPDDT 618
>M55284-1|AAA60100.1| 682|Homo sapiens protein kinase C-L protein.
Length = 682
Score = 71.3 bits (167), Expect = 3e-12
Identities = 58/198 (29%), Positives = 89/198 (44%), Gaps = 3/198 (1%)
Frame = +2
Query: 17 AVKLLH--VLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGM 190
AVK+L V+ L DD T K +S+ R H L P RL V G
Sbjct: 381 AVKVLKKDVILLDDDVECTMTEKRILSLARN--HPFLTQLFCCFQTPDRLFFVMEFVNGG 438
Query: 191 TLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLE-SGKVVITDF 367
L HI + +F ++ A +I + +LH +GII++DLK N+ L+ G + DF
Sbjct: 439 DLMFHIQ-KSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADF 497
Query: 368 GLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVW 547
G +C G + G Y+APEI++ + + A D +A G +
Sbjct: 498 G------MCKEGICNGVTTATFCGTPDYIAPEILQEML--------YGPAVDWWAMGVLL 543
Query: 548 YELLCGEFPFKGQPPESI 601
YE+LCG PF+ + + +
Sbjct: 544 YEMLCGHAPFEAENEDDL 561
>BC020479-1|AAH20479.1| 466|Homo sapiens AKT3 protein protein.
Length = 466
Score = 71.3 bits (167), Expect = 3e-12
Identities = 49/174 (28%), Positives = 79/174 (45%), Gaps = 1/174 (0%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E + + TRH L + RL V G L+ H+ R+ F+ +++ +
Sbjct: 196 ESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLS-RERVFSEDRTRFYGAE 254
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSG 439
I + YLH+ I+++DLK +N+ L+ G + ITDFGL C ++ G
Sbjct: 255 IVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGL------CKEGITDAATMKTFCG 308
Query: 440 WLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESI 601
YLAPE++ + +A D + G V YE++CG PF Q E +
Sbjct: 309 TPEYLAPEVLEDN--------DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 354
>BC002363-1|AAH02363.1| 733|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 2 protein.
Length = 733
Score = 71.3 bits (167), Expect = 3e-12
Identities = 50/171 (29%), Positives = 87/171 (50%), Gaps = 1/171 (0%)
Frame = +2
Query: 77 KHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVA 256
K E I + H +V A +L ++ +G L+T + ++ FT
Sbjct: 107 KMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLS-KEVMFTEEDVKFYL 165
Query: 257 QQISQGMGYLHARGIIHKDLKTKNIFL-ESGKVVITDFGLFSVTKLCFGNNARGDSLGIP 433
+++ + +LH+ GII++DLK +NI L E G + ITDFGL +K ++ R S
Sbjct: 166 AELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGL---SKEAIDHDKRAYSF--- 219
Query: 434 SGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQ 586
G + Y+APE++ R H +++ D ++FG + +E+L G PF+G+
Sbjct: 220 CGTIEYMAPEVVNR-RGH-------TQSADWWSFGVLMFEMLTGSLPFQGK 262
Score = 56.4 bits (130), Expect = 8e-08
Identities = 51/187 (27%), Positives = 85/187 (45%), Gaps = 5/187 (2%)
Frame = +2
Query: 53 DGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFT 232
D S D + + R +H N++ + +V L +G L I LR+ F+
Sbjct: 447 DKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRI-LRQRYFS 505
Query: 233 ANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL--ESG---KVVITDFGLFSVTKLCF 397
++ V I++ M YLH++G++H+DLK NI ESG + + DFG +L
Sbjct: 506 EREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGF--AKQLRA 563
Query: 398 GNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
GN L P ++APE+++ + A DI++ G + Y +L G PF
Sbjct: 564 GNGL----LMTPCYTANFVAPEVLKR--------QGYDAACDIWSLGILLYTMLAGFTPF 611
Query: 578 KGQPPES 598
P ++
Sbjct: 612 ANGPDDT 618
>AY005799-1|AAF91073.1| 465|Homo sapiens protein kinase B gamma 1
protein.
Length = 465
Score = 71.3 bits (167), Expect = 3e-12
Identities = 49/174 (28%), Positives = 79/174 (45%), Gaps = 1/174 (0%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E + + TRH L + RL V G L+ H+ R+ F+ +++ +
Sbjct: 196 ESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLS-RERVFSEDRTRFYGAE 254
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSG 439
I + YLH+ I+++DLK +N+ L+ G + ITDFGL C ++ G
Sbjct: 255 IVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGL------CKEGITDAATMKTFCG 308
Query: 440 WLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESI 601
YLAPE++ + +A D + G V YE++CG PF Q E +
Sbjct: 309 TPEYLAPEVLEDN--------DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 354
>AL662889-3|CAH73073.1| 479|Homo sapiens v-akt murine thymoma viral
oncogene homolog 3 (protein kinase B, gamma) protein.
Length = 479
Score = 71.3 bits (167), Expect = 3e-12
Identities = 49/174 (28%), Positives = 79/174 (45%), Gaps = 1/174 (0%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E + + TRH L + RL V G L+ H+ R+ F+ +++ +
Sbjct: 196 ESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLS-RERVFSEDRTRFYGAE 254
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSG 439
I + YLH+ I+++DLK +N+ L+ G + ITDFGL C ++ G
Sbjct: 255 IVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGL------CKEGITDAATMKTFCG 308
Query: 440 WLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESI 601
YLAPE++ + +A D + G V YE++CG PF Q E +
Sbjct: 309 TPEYLAPEVLEDN--------DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 354
>AL662889-2|CAH73072.1| 465|Homo sapiens v-akt murine thymoma viral
oncogene homolog 3 (protein kinase B, gamma) protein.
Length = 465
Score = 71.3 bits (167), Expect = 3e-12
Identities = 49/174 (28%), Positives = 79/174 (45%), Gaps = 1/174 (0%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E + + TRH L + RL V G L+ H+ R+ F+ +++ +
Sbjct: 196 ESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLS-RERVFSEDRTRFYGAE 254
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSG 439
I + YLH+ I+++DLK +N+ L+ G + ITDFGL C ++ G
Sbjct: 255 IVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGL------CKEGITDAATMKTFCG 308
Query: 440 WLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESI 601
YLAPE++ + +A D + G V YE++CG PF Q E +
Sbjct: 309 TPEYLAPEVLEDN--------DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 354
>AL592151-2|CAH72892.1| 479|Homo sapiens v-akt murine thymoma viral
oncogene homolog 3 (protein kinase B, gamma) protein.
Length = 479
Score = 71.3 bits (167), Expect = 3e-12
Identities = 49/174 (28%), Positives = 79/174 (45%), Gaps = 1/174 (0%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E + + TRH L + RL V G L+ H+ R+ F+ +++ +
Sbjct: 196 ESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLS-RERVFSEDRTRFYGAE 254
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSG 439
I + YLH+ I+++DLK +N+ L+ G + ITDFGL C ++ G
Sbjct: 255 IVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGL------CKEGITDAATMKTFCG 308
Query: 440 WLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESI 601
YLAPE++ + +A D + G V YE++CG PF Q E +
Sbjct: 309 TPEYLAPEVLEDN--------DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 354
>AL592151-1|CAH72891.1| 465|Homo sapiens v-akt murine thymoma viral
oncogene homolog 3 (protein kinase B, gamma) protein.
Length = 465
Score = 71.3 bits (167), Expect = 3e-12
Identities = 49/174 (28%), Positives = 79/174 (45%), Gaps = 1/174 (0%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E + + TRH L + RL V G L+ H+ R+ F+ +++ +
Sbjct: 196 ESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLS-RERVFSEDRTRFYGAE 254
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSG 439
I + YLH+ I+++DLK +N+ L+ G + ITDFGL C ++ G
Sbjct: 255 IVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGL------CKEGITDAATMKTFCG 308
Query: 440 WLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESI 601
YLAPE++ + +A D + G V YE++CG PF Q E +
Sbjct: 309 TPEYLAPEVLEDN--------DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 354
>AL591721-2|CAH71867.1| 479|Homo sapiens v-akt murine thymoma viral
oncogene homolog 3 (protein kinase B, gamma) protein.
Length = 479
Score = 71.3 bits (167), Expect = 3e-12
Identities = 49/174 (28%), Positives = 79/174 (45%), Gaps = 1/174 (0%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E + + TRH L + RL V G L+ H+ R+ F+ +++ +
Sbjct: 196 ESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLS-RERVFSEDRTRFYGAE 254
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSG 439
I + YLH+ I+++DLK +N+ L+ G + ITDFGL C ++ G
Sbjct: 255 IVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGL------CKEGITDAATMKTFCG 308
Query: 440 WLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESI 601
YLAPE++ + +A D + G V YE++CG PF Q E +
Sbjct: 309 TPEYLAPEVLEDN--------DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 354
>AL591721-1|CAH71866.1| 465|Homo sapiens v-akt murine thymoma viral
oncogene homolog 3 (protein kinase B, gamma) protein.
Length = 465
Score = 71.3 bits (167), Expect = 3e-12
Identities = 49/174 (28%), Positives = 79/174 (45%), Gaps = 1/174 (0%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E + + TRH L + RL V G L+ H+ R+ F+ +++ +
Sbjct: 196 ESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLS-RERVFSEDRTRFYGAE 254
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSG 439
I + YLH+ I+++DLK +N+ L+ G + ITDFGL C ++ G
Sbjct: 255 IVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGL------CKEGITDAATMKTFCG 308
Query: 440 WLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESI 601
YLAPE++ + +A D + G V YE++CG PF Q E +
Sbjct: 309 TPEYLAPEVLEDN--------DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 354
>AL022069-2|CAI19651.1| 733|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 2 protein.
Length = 733
Score = 71.3 bits (167), Expect = 3e-12
Identities = 50/171 (29%), Positives = 87/171 (50%), Gaps = 1/171 (0%)
Frame = +2
Query: 77 KHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVA 256
K E I + H +V A +L ++ +G L+T + ++ FT
Sbjct: 107 KMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLS-KEVMFTEEDVKFYL 165
Query: 257 QQISQGMGYLHARGIIHKDLKTKNIFL-ESGKVVITDFGLFSVTKLCFGNNARGDSLGIP 433
+++ + +LH+ GII++DLK +NI L E G + ITDFGL +K ++ R S
Sbjct: 166 AELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGL---SKEAIDHDKRAYSF--- 219
Query: 434 SGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQ 586
G + Y+APE++ R H +++ D ++FG + +E+L G PF+G+
Sbjct: 220 CGTIEYMAPEVVNR-RGH-------TQSADWWSFGVLMFEMLTGSLPFQGK 262
Score = 56.4 bits (130), Expect = 8e-08
Identities = 51/187 (27%), Positives = 85/187 (45%), Gaps = 5/187 (2%)
Frame = +2
Query: 53 DGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFT 232
D S D + + R +H N++ + +V L +G L I LR+ F+
Sbjct: 447 DKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRI-LRQRYFS 505
Query: 233 ANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL--ESG---KVVITDFGLFSVTKLCF 397
++ V I++ M YLH++G++H+DLK NI ESG + + DFG +L
Sbjct: 506 EREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGF--AKQLRA 563
Query: 398 GNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
GN L P ++APE+++ + A DI++ G + Y +L G PF
Sbjct: 564 GNGL----LMTPCYTANFVAPEVLKR--------QGYDAACDIWSLGILLYTMLAGFTPF 611
Query: 578 KGQPPES 598
P ++
Sbjct: 612 ANGPDDT 618
>AJ311798-1|CAC84640.1| 1036|Homo sapiens mixed lineage kinase 4beta
protein.
Length = 1036
Score = 71.3 bits (167), Expect = 3e-12
Identities = 60/213 (28%), Positives = 96/213 (45%), Gaps = 19/213 (8%)
Frame = +2
Query: 2 WHGA-VAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSL 178
W G VAVK P D + ++ + E +F RH N++ G C++ P L +V
Sbjct: 143 WQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEF 202
Query: 179 CKGMTLYTHIHL-------------RKDKFTANKSVLVAQQISQGMGYLHARG---IIHK 310
+G L + R + + V A QI++GM YLH I+H+
Sbjct: 203 ARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHR 262
Query: 311 DLKTKNIFLESGKVVITDF--GLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRP 484
DLK+ NI L ++ D +T + +G ++APE+I++
Sbjct: 263 DLKSSNILLLE-EIEHDDICNKTLKITDFGLAREWHRTTKMSTAGTYAWMAPEVIKS--- 318
Query: 485 HASLLLPFSKATDIYAFGTVWYELLCGEFPFKG 583
SL FSK +DI++ G + +ELL GE P++G
Sbjct: 319 --SL---FSKGSDIWSCGVLLWELLTGEVPYRG 346
>AJ311797-1|CAC84639.1| 570|Homo sapiens mixed lineage kinase
4alpha protein.
Length = 570
Score = 71.3 bits (167), Expect = 3e-12
Identities = 60/213 (28%), Positives = 96/213 (45%), Gaps = 19/213 (8%)
Frame = +2
Query: 2 WHGA-VAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSL 178
W G VAVK P D + ++ + E +F RH N++ G C++ P L +V
Sbjct: 143 WQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEF 202
Query: 179 CKGMTLYTHIHL-------------RKDKFTANKSVLVAQQISQGMGYLHARG---IIHK 310
+G L + R + + V A QI++GM YLH I+H+
Sbjct: 203 ARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHR 262
Query: 311 DLKTKNIFLESGKVVITDF--GLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRP 484
DLK+ NI L ++ D +T + +G ++APE+I++
Sbjct: 263 DLKSSNILLLE-EIEHDDICNKTLKITDFGLAREWHRTTKMSTAGTYAWMAPEVIKS--- 318
Query: 485 HASLLLPFSKATDIYAFGTVWYELLCGEFPFKG 583
SL FSK +DI++ G + +ELL GE P++G
Sbjct: 319 --SL---FSKGSDIWSCGVLLWELLTGEVPYRG 346
>AJ245709-1|CAB53537.1| 479|Homo sapiens Akt-3 protein protein.
Length = 479
Score = 71.3 bits (167), Expect = 3e-12
Identities = 49/174 (28%), Positives = 79/174 (45%), Gaps = 1/174 (0%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E + + TRH L + RL V G L+ H+ R+ F+ +++ +
Sbjct: 196 ESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLS-RERVFSEDRTRFYGAE 254
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSG 439
I + YLH+ I+++DLK +N+ L+ G + ITDFGL C ++ G
Sbjct: 255 IVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGL------CKEGITDAATMKTFCG 308
Query: 440 WLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESI 601
YLAPE++ + +A D + G V YE++CG PF Q E +
Sbjct: 309 TPEYLAPEVLEDN--------DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 354
>AF135794-1|AAD24196.1| 479|Homo sapiens AKT3 protein kinase
protein.
Length = 479
Score = 71.3 bits (167), Expect = 3e-12
Identities = 49/174 (28%), Positives = 79/174 (45%), Gaps = 1/174 (0%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E + + TRH L + RL V G L+ H+ R+ F+ +++ +
Sbjct: 196 ESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLS-RERVFSEDRTRFYGAE 254
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSG 439
I + YLH+ I+++DLK +N+ L+ G + ITDFGL C ++ G
Sbjct: 255 IVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGL------CKEGITDAATMKTFCG 308
Query: 440 WLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESI 601
YLAPE++ + +A D + G V YE++CG PF Q E +
Sbjct: 309 TPEYLAPEVLEDN--------DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 354
>AF124141-1|AAD29089.1| 479|Homo sapiens protein kinase B gamma
protein.
Length = 479
Score = 71.3 bits (167), Expect = 3e-12
Identities = 49/174 (28%), Positives = 79/174 (45%), Gaps = 1/174 (0%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E + + TRH L + RL V G L+ H+ R+ F+ +++ +
Sbjct: 196 ESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLS-RERVFSEDRTRFYGAE 254
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSG 439
I + YLH+ I+++DLK +N+ L+ G + ITDFGL C ++ G
Sbjct: 255 IVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGL------CKEGITDAATMKTFCG 308
Query: 440 WLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESI 601
YLAPE++ + +A D + G V YE++CG PF Q E +
Sbjct: 309 TPEYLAPEVLEDN--------DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 354
>AF085234-1|AAL40392.1| 479|Homo sapiens STK-2 protein.
Length = 479
Score = 71.3 bits (167), Expect = 3e-12
Identities = 49/174 (28%), Positives = 79/174 (45%), Gaps = 1/174 (0%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E + + TRH L + RL V G L+ H+ R+ F+ +++ +
Sbjct: 196 ESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLS-RERVFSEDRTRFYGAE 254
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSG 439
I + YLH+ I+++DLK +N+ L+ G + ITDFGL C ++ G
Sbjct: 255 IVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGL------CKEGITDAATMKTFCG 308
Query: 440 WLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESI 601
YLAPE++ + +A D + G V YE++CG PF Q E +
Sbjct: 309 TPEYLAPEVLEDN--------DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 354
>AB209116-1|BAD92353.1| 806|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 2 isoform b variant protein.
Length = 806
Score = 71.3 bits (167), Expect = 3e-12
Identities = 50/171 (29%), Positives = 87/171 (50%), Gaps = 1/171 (0%)
Frame = +2
Query: 77 KHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVA 256
K E I + H +V A +L ++ +G L+T + ++ FT
Sbjct: 180 KMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLS-KEVMFTEEDVKFYL 238
Query: 257 QQISQGMGYLHARGIIHKDLKTKNIFL-ESGKVVITDFGLFSVTKLCFGNNARGDSLGIP 433
+++ + +LH+ GII++DLK +NI L E G + ITDFGL +K ++ R S
Sbjct: 239 AELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGL---SKEAIDHDKRAYSF--- 292
Query: 434 SGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQ 586
G + Y+APE++ R H +++ D ++FG + +E+L G PF+G+
Sbjct: 293 CGTIEYMAPEVVNR-RGH-------TQSADWWSFGVLMFEMLTGSLPFQGK 335
Score = 56.4 bits (130), Expect = 8e-08
Identities = 51/187 (27%), Positives = 85/187 (45%), Gaps = 5/187 (2%)
Frame = +2
Query: 53 DGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFT 232
D S D + + R +H N++ + +V L +G L I LR+ F+
Sbjct: 520 DKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRI-LRQRYFS 578
Query: 233 ANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL--ESG---KVVITDFGLFSVTKLCF 397
++ V I++ M YLH++G++H+DLK NI ESG + + DFG +L
Sbjct: 579 EREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGF--AKQLRA 636
Query: 398 GNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
GN L P ++APE+++ + A DI++ G + Y +L G PF
Sbjct: 637 GNGL----LMTPCYTANFVAPEVLKR--------QGYDAACDIWSLGILLYTMLAGFTPF 684
Query: 578 KGQPPES 598
P ++
Sbjct: 685 ANGPDDT 691
>L07598-1|AAC82496.1| 540|Homo sapiens ribosomal protein S6 kinase
2 protein.
Length = 540
Score = 70.9 bits (166), Expect = 4e-12
Identities = 50/171 (29%), Positives = 87/171 (50%), Gaps = 1/171 (0%)
Frame = +2
Query: 77 KHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVA 256
K E I + H +V A +L ++ +G L+T + ++ FT
Sbjct: 108 KMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLS-KEVMFTEEDVKFYL 166
Query: 257 QQISQGMGYLHARGIIHKDLKTKNIFL-ESGKVVITDFGLFSVTKLCFGNNARGDSLGIP 433
+++ + +LH+ GII++DLK +NI L E G + ITDFGL +K ++ R S
Sbjct: 167 AELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGL---SKEAIDHDKRAYSF--- 220
Query: 434 SGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQ 586
G + Y+APE++ R H +++ D ++FG + +E+L G PF+G+
Sbjct: 221 CGTIEYMAPEVVNR-RGH-------TQSADWWSFGVLMFEMLTGALPFQGK 263
Score = 42.3 bits (95), Expect = 0.001
Identities = 24/80 (30%), Positives = 42/80 (52%)
Frame = +2
Query: 92 IFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQ 271
+ R +H N++ + +V L +G L I LR+ F+ ++ V I++
Sbjct: 461 LLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRI-LRQRYFSEREASDVLCTITK 519
Query: 272 GMGYLHARGIIHKDLKTKNI 331
M YLH++G++H+DLK NI
Sbjct: 520 TMDYLHSQGVVHRDLKPSNI 539
>U33053-1|AAC50209.1| 942|Homo sapiens PRK1 protein.
Length = 942
Score = 70.5 bits (165), Expect = 5e-12
Identities = 49/165 (29%), Positives = 74/165 (44%), Gaps = 1/165 (0%)
Frame = +2
Query: 110 HENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLH 289
H LV G P + V G L HIH D F+ +++ + + G+ +LH
Sbjct: 675 HPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIH--SDVFSEPRAIFYSACVVLGLQFLH 732
Query: 290 ARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEI 466
I+++DLK N+ L++ G V I DFG LC GD G +LAPE+
Sbjct: 733 EHKIVYRDLKLDNLLLDTEGYVKIADFG------LCKEGMGYGDRTSTFCGTPEFLAPEV 786
Query: 467 IRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESI 601
+ +++A D + G + YE+L GE PF G E +
Sbjct: 787 LTD--------TSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEV 823
>S75546-1|AAB33345.1| 942|Homo sapiens protein kinase PRK1 protein.
Length = 942
Score = 70.5 bits (165), Expect = 5e-12
Identities = 49/165 (29%), Positives = 74/165 (44%), Gaps = 1/165 (0%)
Frame = +2
Query: 110 HENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLH 289
H LV G P + V G L HIH D F+ +++ + + G+ +LH
Sbjct: 675 HPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIH--SDVFSEPRAIFYSACVVLGLQFLH 732
Query: 290 ARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEI 466
I+++DLK N+ L++ G V I DFG LC GD G +LAPE+
Sbjct: 733 EHKIVYRDLKLDNLLLDTEGYVKIADFG------LCKEGMGYGDRTSTFCGTPEFLAPEV 786
Query: 467 IRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESI 601
+ +++A D + G + YE+L GE PF G E +
Sbjct: 787 LTD--------TSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEV 823
>L07868-1|AAB59446.1| 1308|Homo sapiens receptor tyrosine kinase
protein.
Length = 1308
Score = 70.5 bits (165), Expect = 5e-12
Identities = 53/180 (29%), Positives = 87/180 (48%), Gaps = 4/180 (2%)
Frame = +2
Query: 74 FKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLV 253
F E I H +LV +G C+ P + +VT L L ++H KD + +
Sbjct: 765 FMDEALIMASMDHPHLVRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNW 823
Query: 254 AQQISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLG- 427
QI++GM YL R ++H+DL +N+ ++S V ITDFGL +L G+ ++ G
Sbjct: 824 CVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGL---ARLLEGDEKEYNADGG 880
Query: 428 -IPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFG-TVWYELLCGEFPFKGQPPESI 601
+P W +A E I + F+ +D++++G T+W + G P+ G P I
Sbjct: 881 KMPIKW---MALECIHYRK--------FTHQSDVWSYGVTIWELMTFGGKPYDGIPTREI 929
>D26181-1|BAA05169.1| 942|Homo sapiens PKN protein.
Length = 942
Score = 70.5 bits (165), Expect = 5e-12
Identities = 49/165 (29%), Positives = 74/165 (44%), Gaps = 1/165 (0%)
Frame = +2
Query: 110 HENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLH 289
H LV G P + V G L HIH D F+ +++ + + G+ +LH
Sbjct: 675 HPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIH--SDVFSEPRAIFYSACVVLGLQFLH 732
Query: 290 ARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEI 466
I+++DLK N+ L++ G V I DFG LC GD G +LAPE+
Sbjct: 733 EHKIVYRDLKLDNLLLDTEGYVKIADFG------LCKEGMGYGDRTSTFCGTPEFLAPEV 786
Query: 467 IRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESI 601
+ +++A D + G + YE+L GE PF G E +
Sbjct: 787 LTD--------TSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEV 823
>BC125199-1|AAI25200.1| 936|Homo sapiens PKN2 protein protein.
Length = 936
Score = 70.5 bits (165), Expect = 5e-12
Identities = 55/183 (30%), Positives = 79/183 (43%), Gaps = 4/183 (2%)
Frame = +2
Query: 65 LDTFKHEVSIFR---KTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTA 235
+D+ E IF RH LV + V G L HIH D F+
Sbjct: 651 VDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT--DVFSE 708
Query: 236 NKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNAR 412
++V A + G+ YLH I+++DLK N+ L++ G V I DFG LC
Sbjct: 709 PRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGLVKIADFG------LCKEGMGY 762
Query: 413 GDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPP 592
GD G +LAPE++ +++A D + G + YE+L GE PF G
Sbjct: 763 GDRTSTFCGTPEFLAPEVLTE--------TSYTRAVDWWGLGVLIYEMLVGESPFPGDDE 814
Query: 593 ESI 601
E +
Sbjct: 815 EEV 817
>BC112199-1|AAI12200.1| 1308|Homo sapiens v-erb-a erythroblastic
leukemia viral oncogene homolog 4 (avian) protein.
Length = 1308
Score = 70.5 bits (165), Expect = 5e-12
Identities = 53/180 (29%), Positives = 87/180 (48%), Gaps = 4/180 (2%)
Frame = +2
Query: 74 FKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLV 253
F E I H +LV +G C+ P + +VT L L ++H KD + +
Sbjct: 765 FMDEALIMASMDHPHLVRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNW 823
Query: 254 AQQISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLG- 427
QI++GM YL R ++H+DL +N+ ++S V ITDFGL +L G+ ++ G
Sbjct: 824 CVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGL---ARLLEGDEKEYNADGG 880
Query: 428 -IPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFG-TVWYELLCGEFPFKGQPPESI 601
+P W +A E I + F+ +D++++G T+W + G P+ G P I
Sbjct: 881 KMPIKW---MALECIHYRK--------FTHQSDVWSYGVTIWELMTFGGKPYDGIPTREI 929
>BC040061-1|AAH40061.1| 942|Homo sapiens protein kinase N1 protein.
Length = 942
Score = 70.5 bits (165), Expect = 5e-12
Identities = 49/165 (29%), Positives = 74/165 (44%), Gaps = 1/165 (0%)
Frame = +2
Query: 110 HENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLH 289
H LV G P + V G L HIH D F+ +++ + + G+ +LH
Sbjct: 675 HPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIH--SDVFSEPRAIFYSACVVLGLQFLH 732
Query: 290 ARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEI 466
I+++DLK N+ L++ G V I DFG LC GD G +LAPE+
Sbjct: 733 EHKIVYRDLKLDNLLLDTEGYVKIADFG------LCKEGMGYGDRTSTFCGTPEFLAPEV 786
Query: 467 IRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESI 601
+ +++A D + G + YE+L GE PF G E +
Sbjct: 787 LTD--------TSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEV 823
>BC039695-1|AAH39695.1| 1129|Homo sapiens JAK2 protein protein.
Length = 1129
Score = 70.5 bits (165), Expect = 5e-12
Identities = 56/187 (29%), Positives = 88/187 (47%), Gaps = 6/187 (3%)
Frame = +2
Query: 65 LDTFKHEVSIFRKTRHENLVLFMGACMKPPR--LAIVTSLCKGMTLYTHIHLRKDKFTAN 238
L F+ E+ I + +H+N+V + G C R L ++ +L ++ K++
Sbjct: 889 LRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHI 948
Query: 239 KSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSV---TKLCFGNN 406
K + QI +GM YL + IH+DL T+NI +E+ +V I DFGL V K +
Sbjct: 949 KLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVK 1008
Query: 407 ARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQ 586
G+S P W APE + + FS A+D+++FG V YEL K
Sbjct: 1009 EPGES---PIFW---YAPESLTESK--------FSVASDVWSFGVVLYELFTYIEKSKSP 1054
Query: 587 PPESIHL 607
P E + +
Sbjct: 1055 PAEFMRM 1061
Score = 41.5 bits (93), Expect = 0.003
Identities = 25/90 (27%), Positives = 44/90 (48%)
Frame = +2
Query: 68 DTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSV 247
++F S+ K H++LVL G C+ +V K +L T++ K+ +
Sbjct: 589 ESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKL 648
Query: 248 LVAQQISQGMGYLHARGIIHKDLKTKNIFL 337
VA+Q++ M +L +IH ++ KNI L
Sbjct: 649 EVAKQLAWAMHFLEENTLIHGNVCAKNILL 678
>AY973034-1|AAY22962.1| 1132|Homo sapiens Janus kinase 2 protein.
Length = 1132
Score = 70.5 bits (165), Expect = 5e-12
Identities = 56/187 (29%), Positives = 88/187 (47%), Gaps = 6/187 (3%)
Frame = +2
Query: 65 LDTFKHEVSIFRKTRHENLVLFMGACMKPPR--LAIVTSLCKGMTLYTHIHLRKDKFTAN 238
L F+ E+ I + +H+N+V + G C R L ++ +L ++ K++
Sbjct: 892 LRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHI 951
Query: 239 KSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSV---TKLCFGNN 406
K + QI +GM YL + IH+DL T+NI +E+ +V I DFGL V K +
Sbjct: 952 KLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVK 1011
Query: 407 ARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQ 586
G+S P W APE + + FS A+D+++FG V YEL K
Sbjct: 1012 EPGES---PIFW---YAPESLTESK--------FSVASDVWSFGVVLYELFTYIEKSKSP 1057
Query: 587 PPESIHL 607
P E + +
Sbjct: 1058 PAEFMRM 1064
Score = 41.1 bits (92), Expect = 0.003
Identities = 25/90 (27%), Positives = 43/90 (47%)
Frame = +2
Query: 68 DTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSV 247
++F S+ K H++LVL G C +V K +L T++ K+ +
Sbjct: 592 ESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKL 651
Query: 248 LVAQQISQGMGYLHARGIIHKDLKTKNIFL 337
VA+Q++ M +L +IH ++ KNI L
Sbjct: 652 EVAKQLAWAMHFLEENTLIHGNVCAKNILL 681
>AL161450-1|CAD13329.1| 1132|Homo sapiens Janus kinase 2 (a protein
tyrosine kinase) protein.
Length = 1132
Score = 70.5 bits (165), Expect = 5e-12
Identities = 56/187 (29%), Positives = 88/187 (47%), Gaps = 6/187 (3%)
Frame = +2
Query: 65 LDTFKHEVSIFRKTRHENLVLFMGACMKPPR--LAIVTSLCKGMTLYTHIHLRKDKFTAN 238
L F+ E+ I + +H+N+V + G C R L ++ +L ++ K++
Sbjct: 892 LRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHI 951
Query: 239 KSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSV---TKLCFGNN 406
K + QI +GM YL + IH+DL T+NI +E+ +V I DFGL V K +
Sbjct: 952 KLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVK 1011
Query: 407 ARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQ 586
G+S P W APE + + FS A+D+++FG V YEL K
Sbjct: 1012 EPGES---PIFW---YAPESLTESK--------FSVASDVWSFGVVLYELFTYIEKSKSP 1057
Query: 587 PPESIHL 607
P E + +
Sbjct: 1058 PAEFMRM 1064
Score = 41.5 bits (93), Expect = 0.003
Identities = 25/90 (27%), Positives = 44/90 (48%)
Frame = +2
Query: 68 DTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSV 247
++F S+ K H++LVL G C+ +V K +L T++ K+ +
Sbjct: 592 ESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKL 651
Query: 248 LVAQQISQGMGYLHARGIIHKDLKTKNIFL 337
VA+Q++ M +L +IH ++ KNI L
Sbjct: 652 EVAKQLAWAMHFLEENTLIHGNVCAKNILL 681
>AF058925-1|AAC23982.1| 1132|Homo sapiens Jak2 kinase protein.
Length = 1132
Score = 70.5 bits (165), Expect = 5e-12
Identities = 56/187 (29%), Positives = 88/187 (47%), Gaps = 6/187 (3%)
Frame = +2
Query: 65 LDTFKHEVSIFRKTRHENLVLFMGACMKPPR--LAIVTSLCKGMTLYTHIHLRKDKFTAN 238
L F+ E+ I + +H+N+V + G C R L ++ +L ++ K++
Sbjct: 892 LRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHI 951
Query: 239 KSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSV---TKLCFGNN 406
K + QI +GM YL + IH+DL T+NI +E+ +V I DFGL V K +
Sbjct: 952 KLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVK 1011
Query: 407 ARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQ 586
G+S P W APE + + FS A+D+++FG V YEL K
Sbjct: 1012 EPGES---PIFW---YAPESLTESK--------FSVASDVWSFGVVLYELFTYIEKSKSP 1057
Query: 587 PPESIHL 607
P E + +
Sbjct: 1058 PAEFMRM 1064
Score = 41.5 bits (93), Expect = 0.003
Identities = 25/90 (27%), Positives = 44/90 (48%)
Frame = +2
Query: 68 DTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSV 247
++F S+ K H++LVL G C+ +V K +L T++ K+ +
Sbjct: 592 ESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKL 651
Query: 248 LVAQQISQGMGYLHARGIIHKDLKTKNIFL 337
VA+Q++ M +L +IH ++ KNI L
Sbjct: 652 EVAKQLAWAMHFLEENTLIHGNVCAKNILL 681
>AF005216-1|AAB82092.1| 1132|Homo sapiens receptor-associated tyrosine
kinase protein.
Length = 1132
Score = 70.5 bits (165), Expect = 5e-12
Identities = 56/187 (29%), Positives = 88/187 (47%), Gaps = 6/187 (3%)
Frame = +2
Query: 65 LDTFKHEVSIFRKTRHENLVLFMGACMKPPR--LAIVTSLCKGMTLYTHIHLRKDKFTAN 238
L F+ E+ I + +H+N+V + G C R L ++ +L ++ K++
Sbjct: 892 LRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHI 951
Query: 239 KSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSV---TKLCFGNN 406
K + QI +GM YL + IH+DL T+NI +E+ +V I DFGL V K +
Sbjct: 952 KLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVK 1011
Query: 407 ARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQ 586
G+S P W APE + + FS A+D+++FG V YEL K
Sbjct: 1012 EPGES---PIFW---YAPESLTESK--------FSVASDVWSFGVVLYELFTYIEKSKSP 1057
Query: 587 PPESIHL 607
P E + +
Sbjct: 1058 PAEFMRM 1064
Score = 41.5 bits (93), Expect = 0.003
Identities = 25/90 (27%), Positives = 44/90 (48%)
Frame = +2
Query: 68 DTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSV 247
++F S+ K H++LVL G C+ +V K +L T++ K+ +
Sbjct: 592 ESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKL 651
Query: 248 LVAQQISQGMGYLHARGIIHKDLKTKNIFL 337
VA+Q++ M +L +IH ++ KNI L
Sbjct: 652 EVAKQLAWAMHFLEENTLIHGNVCAKNILL 681
>AF001362-1|AAC23653.1| 1132|Homo sapiens Jak2 kinase protein.
Length = 1132
Score = 70.5 bits (165), Expect = 5e-12
Identities = 56/187 (29%), Positives = 88/187 (47%), Gaps = 6/187 (3%)
Frame = +2
Query: 65 LDTFKHEVSIFRKTRHENLVLFMGACMKPPR--LAIVTSLCKGMTLYTHIHLRKDKFTAN 238
L F+ E+ I + +H+N+V + G C R L ++ +L ++ K++
Sbjct: 892 LRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHI 951
Query: 239 KSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSV---TKLCFGNN 406
K + QI +GM YL + IH+DL T+NI +E+ +V I DFGL V K +
Sbjct: 952 KLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVK 1011
Query: 407 ARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQ 586
G+S P W APE + + FS A+D+++FG V YEL K
Sbjct: 1012 EPGES---PIFW---YAPESLTESK--------FSVASDVWSFGVVLYELFTYIEKSKSP 1057
Query: 587 PPESIHL 607
P E + +
Sbjct: 1058 PAEFMRM 1064
Score = 41.5 bits (93), Expect = 0.003
Identities = 25/90 (27%), Positives = 44/90 (48%)
Frame = +2
Query: 68 DTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSV 247
++F S+ K H++LVL G C+ +V K +L T++ K+ +
Sbjct: 592 ESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKL 651
Query: 248 LVAQQISQGMGYLHARGIIHKDLKTKNIFL 337
VA+Q++ M +L +IH ++ KNI L
Sbjct: 652 EVAKQLAWAMHFLEENTLIHGNVCAKNILL 681
>AB209697-1|BAD92934.1| 892|Homo sapiens v-erb-a erythroblastic
leukemia viral oncogene homolog 4 variant protein.
Length = 892
Score = 70.5 bits (165), Expect = 5e-12
Identities = 53/180 (29%), Positives = 87/180 (48%), Gaps = 4/180 (2%)
Frame = +2
Query: 74 FKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLV 253
F E I H +LV +G C+ P + +VT L L ++H KD + +
Sbjct: 365 FMDEALIMASMDHPHLVRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNW 423
Query: 254 AQQISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLG- 427
QI++GM YL R ++H+DL +N+ ++S V ITDFGL +L G+ ++ G
Sbjct: 424 CVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGL---ARLLEGDEKEYNADGG 480
Query: 428 -IPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFG-TVWYELLCGEFPFKGQPPESI 601
+P W +A E I + F+ +D++++G T+W + G P+ G P I
Sbjct: 481 KMPIKW---MALECIHYRK--------FTHQSDVWSYGVTIWELMTFGGKPYDGIPTREI 529
>Z84486-1|CAI21678.1| 526|Homo sapiens serum/glucocorticoid
regulated kinase protein.
Length = 526
Score = 70.1 bits (164), Expect = 6e-12
Identities = 50/163 (30%), Positives = 78/163 (47%), Gaps = 1/163 (0%)
Frame = +2
Query: 92 IFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQ 271
+ + +H LV + +L V G L+ H+ R+ F ++ A +I+
Sbjct: 245 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQ-RERCFLEPRARFYAAEIAS 303
Query: 272 GMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLC 448
+GYLH+ I+++DLK +NI L+S G +V+TDFG LC N + G
Sbjct: 304 ALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG------LCKENIEHNSTTSTFCGTPE 357
Query: 449 YLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
YLAPE++ H P+ + D + G V YE+L G PF
Sbjct: 358 YLAPEVL-----HKQ---PYDRTVDWWCLGAVLYEMLYGLPPF 392
>Y10032-1|CAA71138.1| 431|Homo sapiens serine/threonine protein
kinase protein.
Length = 431
Score = 70.1 bits (164), Expect = 6e-12
Identities = 50/163 (30%), Positives = 78/163 (47%), Gaps = 1/163 (0%)
Frame = +2
Query: 92 IFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQ 271
+ + +H LV + +L V G L+ H+ R+ F ++ A +I+
Sbjct: 150 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQ-RERCFLEPRARFYAAEIAS 208
Query: 272 GMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLC 448
+GYLH+ I+++DLK +NI L+S G +V+TDFG LC N + G
Sbjct: 209 ALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG------LCKENIEHNSTTSTFCGTPE 262
Query: 449 YLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
YLAPE++ H P+ + D + G V YE+L G PF
Sbjct: 263 YLAPEVL-----HKQ---PYDRTVDWWCLGAVLYEMLYGLPPF 297
>U33052-1|AAC50208.1| 984|Homo sapiens PRK2 protein.
Length = 984
Score = 70.1 bits (164), Expect = 6e-12
Identities = 55/183 (30%), Positives = 79/183 (43%), Gaps = 4/183 (2%)
Frame = +2
Query: 65 LDTFKHEVSIFR---KTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTA 235
+D+ E IF RH LV + V G L HIH D F+
Sbjct: 699 VDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT--DVFSE 756
Query: 236 NKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNAR 412
++V A + G+ YLH I+++DLK N+ L++ G V I DFG LC
Sbjct: 757 PRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFG------LCKEGMGY 810
Query: 413 GDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPP 592
GD G +LAPE++ +++A D + G + YE+L GE PF G
Sbjct: 811 GDRTSTFCGTPEFLAPEVLTE--------TSYTRAVDWWGLGVLIYEMLVGESPFPGDDE 862
Query: 593 ESI 601
E +
Sbjct: 863 EEV 865
>S75548-1|AAB33346.1| 984|Homo sapiens protein kinase PRK2 protein.
Length = 984
Score = 70.1 bits (164), Expect = 6e-12
Identities = 55/183 (30%), Positives = 79/183 (43%), Gaps = 4/183 (2%)
Frame = +2
Query: 65 LDTFKHEVSIFR---KTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTA 235
+D+ E IF RH LV + V G L HIH D F+
Sbjct: 699 VDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT--DVFSE 756
Query: 236 NKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNAR 412
++V A + G+ YLH I+++DLK N+ L++ G V I DFG LC
Sbjct: 757 PRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFG------LCKEGMGY 810
Query: 413 GDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPP 592
GD G +LAPE++ +++A D + G + YE+L GE PF G
Sbjct: 811 GDRTSTFCGTPEFLAPEVLTE--------TSYTRAVDWWGLGVLIYEMLVGESPFPGDDE 862
Query: 593 ESI 601
E +
Sbjct: 863 EEV 865
>L07032-1|AAA60101.1| 706|Homo sapiens protein kinase C-theta
protein.
Length = 706
Score = 70.1 bits (164), Expect = 6e-12
Identities = 47/149 (31%), Positives = 74/149 (49%), Gaps = 1/149 (0%)
Frame = +2
Query: 158 LAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL 337
L V G L HI KF +++ A +I G+ +LH++GI+++DLK NI L
Sbjct: 454 LFFVMEYLNGGDLMYHIQ-SCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILL 512
Query: 338 E-SGKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSK 514
+ G + I DFG+ L G+ G P Y+APEI+ + ++
Sbjct: 513 DKDGHIKIADFGMCKENML--GDAKTNTFCGTPD----YIAPEILLGQK--------YNH 558
Query: 515 ATDIYAFGTVWYELLCGEFPFKGQPPESI 601
+ D ++FG + YE+L G+ PF GQ E +
Sbjct: 559 SVDWWSFGVLLYEMLIGQSPFHGQDEEEL 587
>L01087-1|AAA75571.1| 706|Homo sapiens protein kinase C-theta
protein.
Length = 706
Score = 70.1 bits (164), Expect = 6e-12
Identities = 47/149 (31%), Positives = 74/149 (49%), Gaps = 1/149 (0%)
Frame = +2
Query: 158 LAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL 337
L V G L HI KF +++ A +I G+ +LH++GI+++DLK NI L
Sbjct: 454 LFFVMEYLNGGDLMYHIQ-SCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILL 512
Query: 338 E-SGKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSK 514
+ G + I DFG+ L G+ G P Y+APEI+ + ++
Sbjct: 513 DKDGHIKIADFGMCKENML--GDAKTNTFCGTPD----YIAPEILLGQK--------YNH 558
Query: 515 ATDIYAFGTVWYELLCGEFPFKGQPPESI 601
+ D ++FG + YE+L G+ PF GQ E +
Sbjct: 559 SVDWWSFGVLLYEMLIGQSPFHGQDEEEL 587
>BC129951-1|AAI29952.1| 854|Homo sapiens MAP3K6 protein protein.
Length = 854
Score = 70.1 bits (164), Expect = 6e-12
Identities = 53/179 (29%), Positives = 86/179 (48%), Gaps = 4/179 (2%)
Frame = +2
Query: 53 DGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFT 232
D E+++ R+ RH+N+V ++G+ + L I G +L + +
Sbjct: 249 DSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLK 308
Query: 233 ANKSVL--VAQQISQGMGYLHARGIIHKDLKTKNIFLE--SGKVVITDFGLFSVTKLCFG 400
N+S + +QI QG+GYLH I+H+D+K N+ + SG + I+DFG +K G
Sbjct: 309 DNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFG---TSKRLAG 365
Query: 401 NNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
++ +G L Y+APEII P + KA DI++ G E+ G PF
Sbjct: 366 ITPCTETF---TGTLQYMAPEIIDQ-GPRG-----YGKAADIWSLGCTVIEMATGRPPF 415
>BC129950-1|AAI29951.1| 854|Homo sapiens MAP3K6 protein protein.
Length = 854
Score = 70.1 bits (164), Expect = 6e-12
Identities = 53/179 (29%), Positives = 86/179 (48%), Gaps = 4/179 (2%)
Frame = +2
Query: 53 DGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFT 232
D E+++ R+ RH+N+V ++G+ + L I G +L + +
Sbjct: 249 DSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLK 308
Query: 233 ANKSVL--VAQQISQGMGYLHARGIIHKDLKTKNIFLE--SGKVVITDFGLFSVTKLCFG 400
N+S + +QI QG+GYLH I+H+D+K N+ + SG + I+DFG +K G
Sbjct: 309 DNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFG---TSKRLAG 365
Query: 401 NNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
++ +G L Y+APEII P + KA DI++ G E+ G PF
Sbjct: 366 ITPCTETF---TGTLQYMAPEIIDQ-GPRG-----YGKAADIWSLGCTVIEMATGRPPF 415
>BC113359-1|AAI13360.1| 706|Homo sapiens protein kinase C, theta
protein.
Length = 706
Score = 70.1 bits (164), Expect = 6e-12
Identities = 47/149 (31%), Positives = 74/149 (49%), Gaps = 1/149 (0%)
Frame = +2
Query: 158 LAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL 337
L V G L HI KF +++ A +I G+ +LH++GI+++DLK NI L
Sbjct: 454 LFFVMEYLNGGDLMYHIQ-SCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILL 512
Query: 338 E-SGKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSK 514
+ G + I DFG+ L G+ G P Y+APEI+ + ++
Sbjct: 513 DKDGHIKIADFGMCKENML--GDAKTNTFCGTPD----YIAPEILLGQK--------YNH 558
Query: 515 ATDIYAFGTVWYELLCGEFPFKGQPPESI 601
+ D ++FG + YE+L G+ PF GQ E +
Sbjct: 559 SVDWWSFGVLLYEMLIGQSPFHGQDEEEL 587
>BC109032-1|AAI09033.1| 441|Homo sapiens MAP3K6 protein protein.
Length = 441
Score = 70.1 bits (164), Expect = 6e-12
Identities = 53/179 (29%), Positives = 86/179 (48%), Gaps = 4/179 (2%)
Frame = +2
Query: 53 DGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFT 232
D E+++ R+ RH+N+V ++G+ + L I G +L + +
Sbjct: 152 DSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLK 211
Query: 233 ANKSVL--VAQQISQGMGYLHARGIIHKDLKTKNIFLE--SGKVVITDFGLFSVTKLCFG 400
N+S + +QI QG+GYLH I+H+D+K N+ + SG + I+DFG +K G
Sbjct: 212 DNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFG---TSKRLAG 268
Query: 401 NNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
++ +G L Y+APEII P + KA DI++ G E+ G PF
Sbjct: 269 ITPCTETF---TGTLQYMAPEIIDQ-GPRG-----YGKAADIWSLGCTVIEMATGRPPF 318
>BC101465-1|AAI01466.1| 706|Homo sapiens protein kinase C, theta
protein.
Length = 706
Score = 70.1 bits (164), Expect = 6e-12
Identities = 47/149 (31%), Positives = 74/149 (49%), Gaps = 1/149 (0%)
Frame = +2
Query: 158 LAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL 337
L V G L HI KF +++ A +I G+ +LH++GI+++DLK NI L
Sbjct: 454 LFFVMEYLNGGDLMYHIQ-SCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILL 512
Query: 338 E-SGKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSK 514
+ G + I DFG+ L G+ G P Y+APEI+ + ++
Sbjct: 513 DKDGHIKIADFGMCKENML--GDAKTNTFCGTPD----YIAPEILLGQK--------YNH 558
Query: 515 ATDIYAFGTVWYELLCGEFPFKGQPPESI 601
+ D ++FG + YE+L G+ PF GQ E +
Sbjct: 559 SVDWWSFGVLLYEMLIGQSPFHGQDEEEL 587
>BC015914-1|AAH15914.1| 797|Homo sapiens MAP3K6 protein protein.
Length = 797
Score = 70.1 bits (164), Expect = 6e-12
Identities = 53/179 (29%), Positives = 86/179 (48%), Gaps = 4/179 (2%)
Frame = +2
Query: 53 DGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFT 232
D E+++ R+ RH+N+V ++G+ + L I G +L + +
Sbjct: 406 DSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLK 465
Query: 233 ANKSVL--VAQQISQGMGYLHARGIIHKDLKTKNIFLE--SGKVVITDFGLFSVTKLCFG 400
N+S + +QI QG+GYLH I+H+D+K N+ + SG + I+DFG +K G
Sbjct: 466 DNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFG---TSKRLAG 522
Query: 401 NNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
++ +G L Y+APEII P + KA DI++ G E+ G PF
Sbjct: 523 ITPCTETF---TGTLQYMAPEIIDQ-GPRG-----YGKAADIWSLGCTVIEMATGRPPF 572
>BC001263-1|AAH01263.1| 431|Homo sapiens serum/glucocorticoid
regulated kinase protein.
Length = 431
Score = 70.1 bits (164), Expect = 6e-12
Identities = 50/163 (30%), Positives = 78/163 (47%), Gaps = 1/163 (0%)
Frame = +2
Query: 92 IFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQ 271
+ + +H LV + +L V G L+ H+ R+ F ++ A +I+
Sbjct: 150 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQ-RERCFLEPRARFYAAEIAS 208
Query: 272 GMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLC 448
+GYLH+ I+++DLK +NI L+S G +V+TDFG LC N + G
Sbjct: 209 ALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG------LCKENIEHNSTTSTFCGTPE 262
Query: 449 YLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
YLAPE++ H P+ + D + G V YE+L G PF
Sbjct: 263 YLAPEVL-----HKQ---PYDRTVDWWCLGAVLYEMLYGLPPF 297
>AL663123-5|CAI14778.1| 797|Homo sapiens mitogen-activated protein
kinase kinase kinase 6 protein.
Length = 797
Score = 70.1 bits (164), Expect = 6e-12
Identities = 53/179 (29%), Positives = 86/179 (48%), Gaps = 4/179 (2%)
Frame = +2
Query: 53 DGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFT 232
D E+++ R+ RH+N+V ++G+ + L I G +L + +
Sbjct: 406 DSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLK 465
Query: 233 ANKSVL--VAQQISQGMGYLHARGIIHKDLKTKNIFLE--SGKVVITDFGLFSVTKLCFG 400
N+S + +QI QG+GYLH I+H+D+K N+ + SG + I+DFG +K G
Sbjct: 466 DNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFG---TSKRLAG 522
Query: 401 NNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
++ +G L Y+APEII P + KA DI++ G E+ G PF
Sbjct: 523 ITPCTETF---TGTLQYMAPEIIDQ-GPRG-----YGKAADIWSLGCTVIEMATGRPPF 572
>AL663123-4|CAM12869.1| 1288|Homo sapiens mitogen-activated protein
kinase kinase kinase 6 protein.
Length = 1288
Score = 70.1 bits (164), Expect = 6e-12
Identities = 53/179 (29%), Positives = 86/179 (48%), Gaps = 4/179 (2%)
Frame = +2
Query: 53 DGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFT 232
D E+++ R+ RH+N+V ++G+ + L I G +L + +
Sbjct: 683 DSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLK 742
Query: 233 ANKSVL--VAQQISQGMGYLHARGIIHKDLKTKNIFLE--SGKVVITDFGLFSVTKLCFG 400
N+S + +QI QG+GYLH I+H+D+K N+ + SG + I+DFG +K G
Sbjct: 743 DNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFG---TSKRLAG 799
Query: 401 NNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
++ +G L Y+APEII P + KA DI++ G E+ G PF
Sbjct: 800 ITPCTETF---TGTLQYMAPEIIDQ-GPRG-----YGKAADIWSLGCTVIEMATGRPPF 849
>AL355881-2|CAH72579.1| 526|Homo sapiens serum/glucocorticoid
regulated kinase protein.
Length = 526
Score = 70.1 bits (164), Expect = 6e-12
Identities = 50/163 (30%), Positives = 78/163 (47%), Gaps = 1/163 (0%)
Frame = +2
Query: 92 IFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQ 271
+ + +H LV + +L V G L+ H+ R+ F ++ A +I+
Sbjct: 245 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQ-RERCFLEPRARFYAAEIAS 303
Query: 272 GMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLC 448
+GYLH+ I+++DLK +NI L+S G +V+TDFG LC N + G
Sbjct: 304 ALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG------LCKENIEHNSTTSTFCGTPE 357
Query: 449 YLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
YLAPE++ H P+ + D + G V YE+L G PF
Sbjct: 358 YLAPEVL-----HKQ---PYDRTVDWWCLGAVLYEMLYGLPPF 392
>AL158043-2|CAC12904.2| 706|Homo sapiens protein kinase C, theta
protein.
Length = 706
Score = 70.1 bits (164), Expect = 6e-12
Identities = 47/149 (31%), Positives = 74/149 (49%), Gaps = 1/149 (0%)
Frame = +2
Query: 158 LAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL 337
L V G L HI KF +++ A +I G+ +LH++GI+++DLK NI L
Sbjct: 454 LFFVMEYLNGGDLMYHIQ-SCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILL 512
Query: 338 E-SGKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSK 514
+ G + I DFG+ L G+ G P Y+APEI+ + ++
Sbjct: 513 DKDGHIKIADFGMCKENML--GDAKTNTFCGTPD----YIAPEILLGQK--------YNH 558
Query: 515 ATDIYAFGTVWYELLCGEFPFKGQPPESI 601
+ D ++FG + YE+L G+ PF GQ E +
Sbjct: 559 SVDWWSFGVLLYEMLIGQSPFHGQDEEEL 587
>AL158043-1|CAI16127.1| 478|Homo sapiens protein kinase C, theta
protein.
Length = 478
Score = 70.1 bits (164), Expect = 6e-12
Identities = 47/149 (31%), Positives = 74/149 (49%), Gaps = 1/149 (0%)
Frame = +2
Query: 158 LAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL 337
L V G L HI KF +++ A +I G+ +LH++GI+++DLK NI L
Sbjct: 226 LFFVMEYLNGGDLMYHIQ-SCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILL 284
Query: 338 E-SGKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSK 514
+ G + I DFG+ L G+ G P Y+APEI+ + ++
Sbjct: 285 DKDGHIKIADFGMCKENML--GDAKTNTFCGTPD----YIAPEILLGQK--------YNH 330
Query: 515 ATDIYAFGTVWYELLCGEFPFKGQPPESI 601
+ D ++FG + YE+L G+ PF GQ E +
Sbjct: 331 SVDWWSFGVLLYEMLIGQSPFHGQDEEEL 359
>AL137145-2|CAC10200.2| 706|Homo sapiens protein kinase C, theta
protein.
Length = 706
Score = 70.1 bits (164), Expect = 6e-12
Identities = 47/149 (31%), Positives = 74/149 (49%), Gaps = 1/149 (0%)
Frame = +2
Query: 158 LAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL 337
L V G L HI KF +++ A +I G+ +LH++GI+++DLK NI L
Sbjct: 454 LFFVMEYLNGGDLMYHIQ-SCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILL 512
Query: 338 E-SGKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSK 514
+ G + I DFG+ L G+ G P Y+APEI+ + ++
Sbjct: 513 DKDGHIKIADFGMCKENML--GDAKTNTFCGTPD----YIAPEILLGQK--------YNH 558
Query: 515 ATDIYAFGTVWYELLCGEFPFKGQPPESI 601
+ D ++FG + YE+L G+ PF GQ E +
Sbjct: 559 SVDWWSFGVLLYEMLIGQSPFHGQDEEEL 587
>AL137145-1|CAI15756.1| 478|Homo sapiens protein kinase C, theta
protein.
Length = 478
Score = 70.1 bits (164), Expect = 6e-12
Identities = 47/149 (31%), Positives = 74/149 (49%), Gaps = 1/149 (0%)
Frame = +2
Query: 158 LAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL 337
L V G L HI KF +++ A +I G+ +LH++GI+++DLK NI L
Sbjct: 226 LFFVMEYLNGGDLMYHIQ-SCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILL 284
Query: 338 E-SGKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSK 514
+ G + I DFG+ L G+ G P Y+APEI+ + ++
Sbjct: 285 DKDGHIKIADFGMCKENML--GDAKTNTFCGTPD----YIAPEILLGQK--------YNH 330
Query: 515 ATDIYAFGTVWYELLCGEFPFKGQPPESI 601
+ D ++FG + YE+L G+ PF GQ E +
Sbjct: 331 SVDWWSFGVLLYEMLIGQSPFHGQDEEEL 359
>AL136381-3|CAI23271.1| 984|Homo sapiens protein kinase N2 protein.
Length = 984
Score = 70.1 bits (164), Expect = 6e-12
Identities = 55/183 (30%), Positives = 79/183 (43%), Gaps = 4/183 (2%)
Frame = +2
Query: 65 LDTFKHEVSIFR---KTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTA 235
+D+ E IF RH LV + V G L HIH D F+
Sbjct: 699 VDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT--DVFSE 756
Query: 236 NKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNAR 412
++V A + G+ YLH I+++DLK N+ L++ G V I DFG LC
Sbjct: 757 PRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFG------LCKEGMGY 810
Query: 413 GDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPP 592
GD G +LAPE++ +++A D + G + YE+L GE PF G
Sbjct: 811 GDRTSTFCGTPEFLAPEVLTE--------TSYTRAVDWWGLGVLIYEMLVGESPFPGDDE 862
Query: 593 ESI 601
E +
Sbjct: 863 EEV 865
>AL135839-4|CAI19721.1| 526|Homo sapiens serum/glucocorticoid
regulated kinase protein.
Length = 526
Score = 70.1 bits (164), Expect = 6e-12
Identities = 50/163 (30%), Positives = 78/163 (47%), Gaps = 1/163 (0%)
Frame = +2
Query: 92 IFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQ 271
+ + +H LV + +L V G L+ H+ R+ F ++ A +I+
Sbjct: 245 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQ-RERCFLEPRARFYAAEIAS 303
Query: 272 GMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLC 448
+GYLH+ I+++DLK +NI L+S G +V+TDFG LC N + G
Sbjct: 304 ALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG------LCKENIEHNSTTSTFCGTPE 357
Query: 449 YLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
YLAPE++ H P+ + D + G V YE+L G PF
Sbjct: 358 YLAPEVL-----HKQ---PYDRTVDWWCLGAVLYEMLYGLPPF 392
>AL135839-3|CAI19720.1| 445|Homo sapiens serum/glucocorticoid
regulated kinase protein.
Length = 445
Score = 70.1 bits (164), Expect = 6e-12
Identities = 50/163 (30%), Positives = 78/163 (47%), Gaps = 1/163 (0%)
Frame = +2
Query: 92 IFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQ 271
+ + +H LV + +L V G L+ H+ R+ F ++ A +I+
Sbjct: 164 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQ-RERCFLEPRARFYAAEIAS 222
Query: 272 GMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLC 448
+GYLH+ I+++DLK +NI L+S G +V+TDFG LC N + G
Sbjct: 223 ALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG------LCKENIEHNSTTSTFCGTPE 276
Query: 449 YLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
YLAPE++ H P+ + D + G V YE+L G PF
Sbjct: 277 YLAPEVL-----HKQ---PYDRTVDWWCLGAVLYEMLYGLPPF 311
>AL135839-2|CAI19719.1| 431|Homo sapiens serum/glucocorticoid
regulated kinase protein.
Length = 431
Score = 70.1 bits (164), Expect = 6e-12
Identities = 50/163 (30%), Positives = 78/163 (47%), Gaps = 1/163 (0%)
Frame = +2
Query: 92 IFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQ 271
+ + +H LV + +L V G L+ H+ R+ F ++ A +I+
Sbjct: 150 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQ-RERCFLEPRARFYAAEIAS 208
Query: 272 GMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLC 448
+GYLH+ I+++DLK +NI L+S G +V+TDFG LC N + G
Sbjct: 209 ALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG------LCKENIEHNSTTSTFCGTPE 262
Query: 449 YLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
YLAPE++ H P+ + D + G V YE+L G PF
Sbjct: 263 YLAPEVL-----HKQ---PYDRTVDWWCLGAVLYEMLYGLPPF 297
>AL135839-1|CAI19718.1| 421|Homo sapiens serum/glucocorticoid
regulated kinase protein.
Length = 421
Score = 70.1 bits (164), Expect = 6e-12
Identities = 50/163 (30%), Positives = 78/163 (47%), Gaps = 1/163 (0%)
Frame = +2
Query: 92 IFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQ 271
+ + +H LV + +L V G L+ H+ R+ F ++ A +I+
Sbjct: 140 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQ-RERCFLEPRARFYAAEIAS 198
Query: 272 GMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLC 448
+GYLH+ I+++DLK +NI L+S G +V+TDFG LC N + G
Sbjct: 199 ALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG------LCKENIEHNSTTSTFCGTPE 252
Query: 449 YLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
YLAPE++ H P+ + D + G V YE+L G PF
Sbjct: 253 YLAPEVL-----HKQ---PYDRTVDWWCLGAVLYEMLYGLPPF 287
>AL023754-2|CAI19990.1| 245|Homo sapiens
calcium/calmodulin-dependent protein kinase IG protein.
Length = 245
Score = 70.1 bits (164), Expect = 6e-12
Identities = 41/123 (33%), Positives = 65/123 (52%), Gaps = 4/123 (3%)
Frame = +2
Query: 17 AVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTL 196
A+K + P D SL ++E+++ +K +HEN+V +V L G L
Sbjct: 50 ALKCIKKSPAFRDSSL----ENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGEL 105
Query: 197 YTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL----ESGKVVITD 364
+ I L + +T + LV QQ+ + YLH GI+H+DLK +N+ E+ K++ITD
Sbjct: 106 FDRI-LERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITD 164
Query: 365 FGL 373
FGL
Sbjct: 165 FGL 167
>AJ000512-1|CAA04146.1| 431|Homo sapiens serine/threonine protein
kinase protein.
Length = 431
Score = 70.1 bits (164), Expect = 6e-12
Identities = 50/163 (30%), Positives = 78/163 (47%), Gaps = 1/163 (0%)
Frame = +2
Query: 92 IFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQ 271
+ + +H LV + +L V G L+ H+ R+ F ++ A +I+
Sbjct: 150 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQ-RERCFLEPRARFYAAEIAS 208
Query: 272 GMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLC 448
+GYLH+ I+++DLK +NI L+S G +V+TDFG LC N + G
Sbjct: 209 ALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG------LCKENIEHNSTTSTFCGTPE 262
Query: 449 YLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
YLAPE++ H P+ + D + G V YE+L G PF
Sbjct: 263 YLAPEVL-----HKQ---PYDRTVDWWCLGAVLYEMLYGLPPF 297
>AF153609-1|AAD41091.1| 431|Homo sapiens serine/threonine protein
kinase sgk protein.
Length = 431
Score = 70.1 bits (164), Expect = 6e-12
Identities = 50/163 (30%), Positives = 78/163 (47%), Gaps = 1/163 (0%)
Frame = +2
Query: 92 IFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQISQ 271
+ + +H LV + +L V G L+ H+ R+ F ++ A +I+
Sbjct: 150 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQ-RERCFLEPRARFYAAEIAS 208
Query: 272 GMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSGWLC 448
+GYLH+ I+++DLK +NI L+S G +V+TDFG LC N + G
Sbjct: 209 ALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG------LCKENIEHNSTTSTFCGTPE 262
Query: 449 YLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
YLAPE++ H P+ + D + G V YE+L G PF
Sbjct: 263 YLAPEVL-----HKQ---PYDRTVDWWCLGAVLYEMLYGLPPF 297
>AF100318-1|AAD05304.1| 1011|Homo sapiens mitogen-activated protein
kinase kinase kinase 6 protein.
Length = 1011
Score = 70.1 bits (164), Expect = 6e-12
Identities = 53/179 (29%), Positives = 86/179 (48%), Gaps = 4/179 (2%)
Frame = +2
Query: 53 DGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFT 232
D E+++ R+ RH+N+V ++G+ + L I G +L + +
Sbjct: 406 DSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLK 465
Query: 233 ANKSVL--VAQQISQGMGYLHARGIIHKDLKTKNIFLE--SGKVVITDFGLFSVTKLCFG 400
N+S + +QI QG+GYLH I+H+D+K N+ + SG + I+DFG +K G
Sbjct: 466 DNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFG---TSKRLAG 522
Query: 401 NNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
++ +G L Y+APEII P + KA DI++ G E+ G PF
Sbjct: 523 ITPCTETF---TGTLQYMAPEIIDQ-GPRG-----YGKAADIWSLGCTVIEMATGRPPF 572
>AB208805-1|BAD92042.1| 1192|Homo sapiens mitogen-activated protein
kinase kinase kinase 6 variant protein.
Length = 1192
Score = 70.1 bits (164), Expect = 6e-12
Identities = 53/179 (29%), Positives = 86/179 (48%), Gaps = 4/179 (2%)
Frame = +2
Query: 53 DGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFT 232
D E+++ R+ RH+N+V ++G+ + L I G +L + +
Sbjct: 587 DSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLK 646
Query: 233 ANKSVL--VAQQISQGMGYLHARGIIHKDLKTKNIFLE--SGKVVITDFGLFSVTKLCFG 400
N+S + +QI QG+GYLH I+H+D+K N+ + SG + I+DFG +K G
Sbjct: 647 DNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFG---TSKRLAG 703
Query: 401 NNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
++ +G L Y+APEII P + KA DI++ G E+ G PF
Sbjct: 704 ITPCTETF---TGTLQYMAPEIIDQ-GPRG-----YGKAADIWSLGCTVIEMATGRPPF 753
>AB167411-1|BAD12485.1| 1288|Homo sapiens apoptosis signal-regulating
kinase 2 protein.
Length = 1288
Score = 70.1 bits (164), Expect = 6e-12
Identities = 53/179 (29%), Positives = 86/179 (48%), Gaps = 4/179 (2%)
Frame = +2
Query: 53 DGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFT 232
D E+++ R+ RH+N+V ++G+ + L I G +L + +
Sbjct: 683 DSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLK 742
Query: 233 ANKSVL--VAQQISQGMGYLHARGIIHKDLKTKNIFLE--SGKVVITDFGLFSVTKLCFG 400
N+S + +QI QG+GYLH I+H+D+K N+ + SG + I+DFG +K G
Sbjct: 743 DNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFG---TSKRLAG 799
Query: 401 NNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
++ +G L Y+APEII P + KA DI++ G E+ G PF
Sbjct: 800 ITPCTETF---TGTLQYMAPEIIDQ-GPRG-----YGKAADIWSLGCTVIEMATGRPPF 849
>U22322-1|AAC50116.1| 505|Homo sapiens Rak protein.
Length = 505
Score = 69.7 bits (163), Expect = 8e-12
Identities = 54/198 (27%), Positives = 91/198 (45%), Gaps = 4/198 (2%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLC 181
W+ V + + P S D + F E I + RH L+ C + I+T L
Sbjct: 253 WNNTTPVAVKTLKPGSMDPN---DFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELM 309
Query: 182 KGMTLYTHIHLRK-DKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL-ESGKVV 355
+ +L ++ K + V +A Q++ GM YL +R IH+DL +N+ + E
Sbjct: 310 RHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYK 369
Query: 356 ITDFGLFSVTKLCFGNNARG-DSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYA 532
+ DFGL V K+ + + +P W APE IR+ + FS +D+++
Sbjct: 370 VADFGLARVFKVDNEDIYESRHEIKLPVKW---TAPEAIRSNK--------FSIKSDVWS 418
Query: 533 FGTVWYELLC-GEFPFKG 583
FG + YE++ G+ P+ G
Sbjct: 419 FGILLYEIITYGKMPYSG 436
>U00803-1|AAA18284.1| 505|Homo sapiens SRC-like tyrosine kinase
protein.
Length = 505
Score = 69.7 bits (163), Expect = 8e-12
Identities = 54/198 (27%), Positives = 91/198 (45%), Gaps = 4/198 (2%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLC 181
W+ V + + P S D + F E I + RH L+ C + I+T L
Sbjct: 253 WNNTTPVAVKTLKPGSMDPN---DFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELM 309
Query: 182 KGMTLYTHIHLRK-DKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL-ESGKVV 355
+ +L ++ K + V +A Q++ GM YL +R IH+DL +N+ + E
Sbjct: 310 RHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYK 369
Query: 356 ITDFGLFSVTKLCFGNNARG-DSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYA 532
+ DFGL V K+ + + +P W APE IR+ + FS +D+++
Sbjct: 370 VADFGLARVFKVDNEDIYESRHEIKLPVKW---TAPEAIRSNK--------FSIKSDVWS 418
Query: 533 FGTVWYELLC-GEFPFKG 583
FG + YE++ G+ P+ G
Sbjct: 419 FGILLYEIITYGKMPYSG 436
>BC012916-1|AAH12916.1| 505|Homo sapiens fyn-related kinase
protein.
Length = 505
Score = 69.7 bits (163), Expect = 8e-12
Identities = 54/198 (27%), Positives = 91/198 (45%), Gaps = 4/198 (2%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLC 181
W+ V + + P S D + F E I + RH L+ C + I+T L
Sbjct: 253 WNNTTPVAVKTLKPGSMDPN---DFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELM 309
Query: 182 KGMTLYTHIHLRK-DKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL-ESGKVV 355
+ +L ++ K + V +A Q++ GM YL +R IH+DL +N+ + E
Sbjct: 310 RHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYK 369
Query: 356 ITDFGLFSVTKLCFGNNARG-DSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYA 532
+ DFGL V K+ + + +P W APE IR+ + FS +D+++
Sbjct: 370 VADFGLARVFKVDNEDIYESRHEIKLPVKW---TAPEAIRSNK--------FSIKSDVWS 418
Query: 533 FGTVWYELLC-GEFPFKG 583
FG + YE++ G+ P+ G
Sbjct: 419 FGILLYEIITYGKMPYSG 436
>AL357141-2|CAI16469.1| 505|Homo sapiens fyn-related kinase
protein.
Length = 505
Score = 69.7 bits (163), Expect = 8e-12
Identities = 54/198 (27%), Positives = 91/198 (45%), Gaps = 4/198 (2%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLC 181
W+ V + + P S D + F E I + RH L+ C + I+T L
Sbjct: 253 WNNTTPVAVKTLKPGSMDPN---DFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELM 309
Query: 182 KGMTLYTHIHLRK-DKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL-ESGKVV 355
+ +L ++ K + V +A Q++ GM YL +R IH+DL +N+ + E
Sbjct: 310 RHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYK 369
Query: 356 ITDFGLFSVTKLCFGNNARG-DSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYA 532
+ DFGL V K+ + + +P W APE IR+ + FS +D+++
Sbjct: 370 VADFGLARVFKVDNEDIYESRHEIKLPVKW---TAPEAIRSNK--------FSIKSDVWS 418
Query: 533 FGTVWYELLC-GEFPFKG 583
FG + YE++ G+ P+ G
Sbjct: 419 FGILLYEIITYGKMPYSG 436
>AL121963-8|CAB87592.2| 505|Homo sapiens fyn-related kinase
protein.
Length = 505
Score = 69.7 bits (163), Expect = 8e-12
Identities = 54/198 (27%), Positives = 91/198 (45%), Gaps = 4/198 (2%)
Frame = +2
Query: 2 WHGAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLC 181
W+ V + + P S D + F E I + RH L+ C + I+T L
Sbjct: 253 WNNTTPVAVKTLKPGSMDPN---DFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELM 309
Query: 182 KGMTLYTHIHLRK-DKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL-ESGKVV 355
+ +L ++ K + V +A Q++ GM YL +R IH+DL +N+ + E
Sbjct: 310 RHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYK 369
Query: 356 ITDFGLFSVTKLCFGNNARG-DSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYA 532
+ DFGL V K+ + + +P W APE IR+ + FS +D+++
Sbjct: 370 VADFGLARVFKVDNEDIYESRHEIKLPVKW---TAPEAIRSNK--------FSIKSDVWS 418
Query: 533 FGTVWYELLC-GEFPFKG 583
FG + YE++ G+ P+ G
Sbjct: 419 FGILLYEIITYGKMPYSG 436
>L33881-1|AAB17011.1| 587|Homo sapiens protein kinase C iota
protein.
Length = 587
Score = 69.3 bits (162), Expect = 1e-11
Identities = 50/180 (27%), Positives = 85/180 (47%), Gaps = 2/180 (1%)
Frame = +2
Query: 44 LSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPP-RLAIVTSLCKGMTLYTHIHLRK 220
L +D +D + E +F + + ++ + +C + RL V G L H+ R+
Sbjct: 280 LVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQ-RQ 338
Query: 221 DKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCF 397
K + + +IS + YLH RGII++DLK N+ L+S G + +TD+G +C
Sbjct: 339 RKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYG------MCK 392
Query: 398 GNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
GD+ G Y+APEI+R + + D +A G + +E++ G PF
Sbjct: 393 EGLRPGDTTSTFCGTPNYIAPEILRG--------EDYGFSVDWWALGVLMFEMMAGRSPF 444
>L18964-1|AAA60171.1| 587|Homo sapiens protein kinase C iota
protein.
Length = 587
Score = 69.3 bits (162), Expect = 1e-11
Identities = 50/180 (27%), Positives = 85/180 (47%), Gaps = 2/180 (1%)
Frame = +2
Query: 44 LSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPP-RLAIVTSLCKGMTLYTHIHLRK 220
L +D +D + E +F + + ++ + +C + RL V G L H+ R+
Sbjct: 280 LVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQ-RQ 338
Query: 221 DKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCF 397
K + + +IS + YLH RGII++DLK N+ L+S G + +TD+G +C
Sbjct: 339 RKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYG------MCK 392
Query: 398 GNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
GD+ G Y+APEI+R + + D +A G + +E++ G PF
Sbjct: 393 EGLRPGDTTSTFCGTPNYIAPEILRG--------EDYGFSVDWWALGVLMFEMMAGRSPF 444
>D50863-1|BAA09459.1| 626|Homo sapiens TESK1 protein.
Length = 626
Score = 69.3 bits (162), Expect = 1e-11
Identities = 55/188 (29%), Positives = 95/188 (50%), Gaps = 4/188 (2%)
Frame = +2
Query: 8 GAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKG 187
G V V ++ LP S+ G+ L EV + + RH N++ FMG C+ +L +T G
Sbjct: 80 GQVMVLKMNKLP-SNRGNTL----REVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNG 134
Query: 188 MTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL---ESG-KVV 355
TL + + + + +A I++G+ YLH++G+ H+DL +KN + + G V
Sbjct: 135 GTL-EQLLSSPEPLSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAV 193
Query: 356 ITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAF 535
+ DFGL + + AR + L + G ++APE++R + + D++AF
Sbjct: 194 VGDFGLAEKIPV-YREGARKEPLAV-VGSPYWMAPEVLRGEL--------YDEKADVFAF 243
Query: 536 GTVWYELL 559
G V EL+
Sbjct: 244 GIVLCELI 251
>BC067130-1|AAH67130.1| 626|Homo sapiens TESK1 protein protein.
Length = 626
Score = 69.3 bits (162), Expect = 1e-11
Identities = 55/188 (29%), Positives = 95/188 (50%), Gaps = 4/188 (2%)
Frame = +2
Query: 8 GAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKG 187
G V V ++ LP S+ G+ L EV + + RH N++ FMG C+ +L +T G
Sbjct: 80 GQVMVLKMNKLP-SNRGNTL----REVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNG 134
Query: 188 MTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL---ESG-KVV 355
TL + + + + +A I++G+ YLH++G+ H+DL +KN + + G V
Sbjct: 135 GTL-EQLLSSPEPLSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAV 193
Query: 356 ITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAF 535
+ DFGL + + AR + L + G ++APE++R + + D++AF
Sbjct: 194 VGDFGLAEKIPV-YREGARKEPLAV-VGSPYWMAPEVLRGEL--------YDEKADVFAF 243
Query: 536 GTVWYELL 559
G V EL+
Sbjct: 244 GIVLCELI 251
>BC038448-1|AAH38448.1| 626|Homo sapiens TESK1 protein protein.
Length = 626
Score = 69.3 bits (162), Expect = 1e-11
Identities = 55/188 (29%), Positives = 95/188 (50%), Gaps = 4/188 (2%)
Frame = +2
Query: 8 GAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKG 187
G V V ++ LP S+ G+ L EV + + RH N++ FMG C+ +L +T G
Sbjct: 80 GQVMVLKMNKLP-SNRGNTL----REVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNG 134
Query: 188 MTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL---ESG-KVV 355
TL + + + + +A I++G+ YLH++G+ H+DL +KN + + G V
Sbjct: 135 GTL-EQLLSSPEPLSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAV 193
Query: 356 ITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAF 535
+ DFGL + + AR + L + G ++APE++R + + D++AF
Sbjct: 194 VGDFGLAEKIPV-YREGARKEPLAV-VGSPYWMAPEVLRGEL--------YDEKADVFAF 243
Query: 536 GTVWYELL 559
G V EL+
Sbjct: 244 GIVLCELI 251
>BC022016-1|AAH22016.3| 587|Homo sapiens protein kinase C, iota
protein.
Length = 587
Score = 69.3 bits (162), Expect = 1e-11
Identities = 50/180 (27%), Positives = 85/180 (47%), Gaps = 2/180 (1%)
Frame = +2
Query: 44 LSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPP-RLAIVTSLCKGMTLYTHIHLRK 220
L +D +D + E +F + + ++ + +C + RL V G L H+ R+
Sbjct: 280 LVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQ-RQ 338
Query: 221 DKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCF 397
K + + +IS + YLH RGII++DLK N+ L+S G + +TD+G +C
Sbjct: 339 RKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYG------MCK 392
Query: 398 GNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPF 577
GD+ G Y+APEI+R + + D +A G + +E++ G PF
Sbjct: 393 EGLRPGDTTSTFCGTPNYIAPEILRG--------EDYGFSVDWWALGVLMFEMMAGRSPF 444
>BC017575-1|AAH17575.1| 476|Homo sapiens CHK1 checkpoint homolog
(S. pombe) protein.
Length = 476
Score = 69.3 bits (162), Expect = 1e-11
Identities = 60/197 (30%), Positives = 91/197 (46%), Gaps = 1/197 (0%)
Frame = +2
Query: 11 AVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGM 190
AVAVK++ + D + K E+ I + HEN+V F G + + C G
Sbjct: 34 AVAVKIVDMKRAVD---CPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGG 90
Query: 191 TLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL-ESGKVVITDF 367
L+ I + Q+ G+ YLH GI H+D+K +N+ L E + I+DF
Sbjct: 91 ELFDRIE-PDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDF 149
Query: 368 GLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVW 547
GL +V F N R L G L Y+APE+++ HA + D+++ G V
Sbjct: 150 GLATV----FRYNNRERLLNKMCGTLPYVAPELLKRREFHA-------EPVDVWSCGIVL 198
Query: 548 YELLCGEFPFKGQPPES 598
+L GE P+ QP +S
Sbjct: 199 TAMLAGELPW-DQPSDS 214
>BC004202-1|AAH04202.1| 476|Homo sapiens CHEK1 protein protein.
Length = 476
Score = 69.3 bits (162), Expect = 1e-11
Identities = 60/197 (30%), Positives = 91/197 (46%), Gaps = 1/197 (0%)
Frame = +2
Query: 11 AVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGM 190
AVAVK++ + D + K E+ I + HEN+V F G + + C G
Sbjct: 34 AVAVKIVDMKRAVD---CPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGG 90
Query: 191 TLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL-ESGKVVITDF 367
L+ I + Q+ G+ YLH GI H+D+K +N+ L E + I+DF
Sbjct: 91 ELFDRIE-PDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDF 149
Query: 368 GLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVW 547
GL +V F N R L G L Y+APE+++ HA + D+++ G V
Sbjct: 150 GLATV----FRYNNRERLLNKMCGTLPYVAPELLKRREFHA-------EPVDVWSCGIVL 198
Query: 548 YELLCGEFPFKGQPPES 598
+L GE P+ QP +S
Sbjct: 199 TAMLAGELPW-DQPSDS 214
>AL357874-1|CAI13441.1| 626|Homo sapiens testis-specific kinase 1
protein.
Length = 626
Score = 69.3 bits (162), Expect = 1e-11
Identities = 55/188 (29%), Positives = 95/188 (50%), Gaps = 4/188 (2%)
Frame = +2
Query: 8 GAVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKG 187
G V V ++ LP S+ G+ L EV + + RH N++ FMG C+ +L +T G
Sbjct: 80 GQVMVLKMNKLP-SNRGNTL----REVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNG 134
Query: 188 MTLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL---ESG-KVV 355
TL + + + + +A I++G+ YLH++G+ H+DL +KN + + G V
Sbjct: 135 GTL-EQLLSSPEPLSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAV 193
Query: 356 ITDFGLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAF 535
+ DFGL + + AR + L + G ++APE++R + + D++AF
Sbjct: 194 VGDFGLAEKIPV-YREGARKEPLAV-VGSPYWMAPEVLRGEL--------YDEKADVFAF 243
Query: 536 GTVWYELL 559
G V EL+
Sbjct: 244 GIVLCELI 251
>AF527555-1|AAM78553.1| 476|Homo sapiens CHK1 checkpoint homolog
(S. pombe) protein.
Length = 476
Score = 69.3 bits (162), Expect = 1e-11
Identities = 60/197 (30%), Positives = 91/197 (46%), Gaps = 1/197 (0%)
Frame = +2
Query: 11 AVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGM 190
AVAVK++ + D + K E+ I + HEN+V F G + + C G
Sbjct: 34 AVAVKIVDMKRAVD---CPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGG 90
Query: 191 TLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL-ESGKVVITDF 367
L+ I + Q+ G+ YLH GI H+D+K +N+ L E + I+DF
Sbjct: 91 ELFDRIE-PDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDF 149
Query: 368 GLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVW 547
GL +V F N R L G L Y+APE+++ HA + D+++ G V
Sbjct: 150 GLATV----FRYNNRERLLNKMCGTLPYVAPELLKRREFHA-------EPVDVWSCGIVL 198
Query: 548 YELLCGEFPFKGQPPES 598
+L GE P+ QP +S
Sbjct: 199 TAMLAGELPW-DQPSDS 214
>AF032874-1|AAB88852.1| 476|Homo sapiens protein kinase protein.
Length = 476
Score = 69.3 bits (162), Expect = 1e-11
Identities = 60/197 (30%), Positives = 91/197 (46%), Gaps = 1/197 (0%)
Frame = +2
Query: 11 AVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGM 190
AVAVK++ + D + K E+ I + HEN+V F G + + C G
Sbjct: 34 AVAVKIVDMKRAVD---CPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGG 90
Query: 191 TLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL-ESGKVVITDF 367
L+ I + Q+ G+ YLH GI H+D+K +N+ L E + I+DF
Sbjct: 91 ELFDRIE-PDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDF 149
Query: 368 GLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVW 547
GL +V F N R L G L Y+APE+++ HA + D+++ G V
Sbjct: 150 GLATV----FRYNNRERLLNKMCGTLPYVAPELLKRREFHA-------EPVDVWSCGIVL 198
Query: 548 YELLCGEFPFKGQPPES 598
+L GE P+ QP +S
Sbjct: 199 TAMLAGELPW-DQPSDS 214
>AF016582-1|AAC51736.1| 476|Homo sapiens Chk1 protein.
Length = 476
Score = 69.3 bits (162), Expect = 1e-11
Identities = 60/197 (30%), Positives = 91/197 (46%), Gaps = 1/197 (0%)
Frame = +2
Query: 11 AVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGM 190
AVAVK++ + D + K E+ I + HEN+V F G + + C G
Sbjct: 34 AVAVKIVDMKRAVD---CPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGG 90
Query: 191 TLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL-ESGKVVITDF 367
L+ I + Q+ G+ YLH GI H+D+K +N+ L E + I+DF
Sbjct: 91 ELFDRIE-PDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDF 149
Query: 368 GLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVW 547
GL +V F N R L G L Y+APE+++ HA + D+++ G V
Sbjct: 150 GLATV----FRYNNRERLLNKMCGTLPYVAPELLKRREFHA-------EPVDVWSCGIVL 198
Query: 548 YELLCGEFPFKGQPPES 598
+L GE P+ QP +S
Sbjct: 199 TAMLAGELPW-DQPSDS 214
>AB032387-1|BAA84577.1| 476|Homo sapiens checkpoint kinase protein.
Length = 476
Score = 69.3 bits (162), Expect = 1e-11
Identities = 60/197 (30%), Positives = 91/197 (46%), Gaps = 1/197 (0%)
Frame = +2
Query: 11 AVAVKLLHVLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGM 190
AVAVK++ + D + K E+ I + HEN+V F G + + C G
Sbjct: 34 AVAVKIVDMKRAVD---CPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGG 90
Query: 191 TLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFL-ESGKVVITDF 367
L+ I + Q+ G+ YLH GI H+D+K +N+ L E + I+DF
Sbjct: 91 ELFDRIE-PDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDF 149
Query: 368 GLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVW 547
GL +V F N R L G L Y+APE+++ HA + D+++ G V
Sbjct: 150 GLATV----FRYNNRERLLNKMCGTLPYVAPELLKRREFHA-------EPVDVWSCGIVL 198
Query: 548 YELLCGEFPFKGQPPES 598
+L GE P+ QP +S
Sbjct: 199 TAMLAGELPW-DQPSDS 214
>M63167-1|AAA36539.1| 480|Homo sapiens rac protein kinase-alpha
protein.
Length = 480
Score = 68.9 bits (161), Expect = 1e-11
Identities = 48/175 (27%), Positives = 81/175 (46%), Gaps = 2/175 (1%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E + + +RH L + RL V G L+ H+ R+ F+ +++ +
Sbjct: 198 ENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS-RERVFSEDRARFYGAE 256
Query: 263 ISQGMGYLHA-RGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPS 436
I + YLH+ + ++++DLK +N+ L+ G + ITDFGL C G ++
Sbjct: 257 IVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGL------CKEGIKDGATMKTFC 310
Query: 437 GWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESI 601
G YLAPE++ + +A D + G V YE++CG PF Q E +
Sbjct: 311 GTPEYLAPEVLEDN--------DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 357
>BC121154-1|AAI21155.1| 465|Homo sapiens v-akt murine thymoma viral
oncogene homolog 3 (protein kinase B, gamma) protein.
Length = 465
Score = 68.9 bits (161), Expect = 1e-11
Identities = 48/174 (27%), Positives = 78/174 (44%), Gaps = 1/174 (0%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E + + TRH L + RL V G L+ H+ R+ F+ +++ +
Sbjct: 196 ESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLS-RERVFSEDRTRFYGAE 254
Query: 263 ISQGMGYLHARGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPSG 439
I + YLH+ I+++DLK +N+ + G + ITDFGL C ++ G
Sbjct: 255 IVSALDYLHSGKIVYRDLKLENLMRDKDGHIKITDFGL------CKEGITDAATMKTFCG 308
Query: 440 WLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESI 601
YLAPE++ + +A D + G V YE++CG PF Q E +
Sbjct: 309 TPEYLAPEVLEDN--------DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 354
>BC084538-1|AAH84538.1| 480|Homo sapiens v-akt murine thymoma viral
oncogene homolog 1 protein.
Length = 480
Score = 68.9 bits (161), Expect = 1e-11
Identities = 48/175 (27%), Positives = 81/175 (46%), Gaps = 2/175 (1%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E + + +RH L + RL V G L+ H+ R+ F+ +++ +
Sbjct: 198 ENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS-RERVFSEDRARFYGAE 256
Query: 263 ISQGMGYLHA-RGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPS 436
I + YLH+ + ++++DLK +N+ L+ G + ITDFGL C G ++
Sbjct: 257 IVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGL------CKEGIKDGATMKTFC 310
Query: 437 GWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESI 601
G YLAPE++ + +A D + G V YE++CG PF Q E +
Sbjct: 311 GTPEYLAPEVLEDN--------DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 357
>BC037268-1|AAH37268.1| 683|Homo sapiens protein kinase C, eta
protein.
Length = 683
Score = 68.9 bits (161), Expect = 1e-11
Identities = 57/198 (28%), Positives = 88/198 (44%), Gaps = 3/198 (1%)
Frame = +2
Query: 17 AVKLLH--VLPLSDDGSLLDTFKHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGM 190
AVK+L V+ DD T K +S+ R H L P RL V G
Sbjct: 382 AVKVLKKDVILQDDDVECTMTEKRILSLARN--HPFLTQLFCCFQTPDRLFFVMEFVNGG 439
Query: 191 TLYTHIHLRKDKFTANKSVLVAQQISQGMGYLHARGIIHKDLKTKNIFLE-SGKVVITDF 367
L HI + +F ++ A +I + +LH +GII++DLK N+ L+ G + DF
Sbjct: 440 DLMFHIQ-KSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADF 498
Query: 368 GLFSVTKLCFGNNARGDSLGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVW 547
G +C G + G Y+APEI++ + + A D +A G +
Sbjct: 499 G------MCKEGICNGVTTATFCGTPDYIAPEILQEML--------YGPAVDWWAMGVLL 544
Query: 548 YELLCGEFPFKGQPPESI 601
YE+LCG PF+ + + +
Sbjct: 545 YEMLCGHAPFEAENEDDL 562
>BC000479-1|AAH00479.1| 480|Homo sapiens v-akt murine thymoma viral
oncogene homolog 1 protein.
Length = 480
Score = 68.9 bits (161), Expect = 1e-11
Identities = 48/175 (27%), Positives = 81/175 (46%), Gaps = 2/175 (1%)
Frame = +2
Query: 83 EVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVAQQ 262
E + + +RH L + RL V G L+ H+ R+ F+ +++ +
Sbjct: 198 ENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS-RERVFSEDRARFYGAE 256
Query: 263 ISQGMGYLHA-RGIIHKDLKTKNIFLES-GKVVITDFGLFSVTKLCFGNNARGDSLGIPS 436
I + YLH+ + ++++DLK +N+ L+ G + ITDFGL C G ++
Sbjct: 257 IVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGL------CKEGIKDGATMKTFC 310
Query: 437 GWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKGQPPESI 601
G YLAPE++ + +A D + G V YE++CG PF Q E +
Sbjct: 311 GTPEYLAPEVLEDN--------DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 357
>AL390029-2|CAI15721.1| 740|Homo sapiens doublecortin and CaM
kinase-like 1 protein.
Length = 740
Score = 68.9 bits (161), Expect = 1e-11
Identities = 52/174 (29%), Positives = 85/174 (48%), Gaps = 5/174 (2%)
Frame = +2
Query: 77 KHEVSIFRKTRHENLVLFMGACMKPPRLAIVTSLCKGMTLYTHIHLRKDKFTANKSVLVA 256
++EVSI R+ +H N+VL + P L +V L KG L+ I +K+T + +
Sbjct: 434 QNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAI-TSTNKYTERDASGML 492
Query: 257 QQISQGMGYLHARGIIHKDLKTKNIFL-----ESGKVVITDFGLFSVTKLCFGNNARGDS 421
++ + YLH+ I+H+D+K +N+ + S + + DFGL ++ +
Sbjct: 493 YNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV-----DGPLYTV 547
Query: 422 LGIPSGWLCYLAPEIIRALRPHASLLLPFSKATDIYAFGTVWYELLCGEFPFKG 583
G P+ Y+APEII + DI+A G + Y LLCG PF+G
Sbjct: 548 CGTPT----YVAPEIIAE--------TGYGLKVDIWAAGVITYILLCGFPPFRG 589
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 96,650,372
Number of Sequences: 237096
Number of extensions: 2285751
Number of successful extensions: 14850
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 12667
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 13586
length of database: 76,859,062
effective HSP length: 87
effective length of database: 56,231,710
effective search space used: 7366354010
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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