Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= ceN-3607
(610 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
U49356-1|AAA90924.1| 2285|Homo sapiens DNA polymerase epsilon ca... 143 4e-34
BC087613-1|AAH87613.1| 797|Homo sapiens POLE protein protein. 143 4e-34
BC021559-1|AAH21559.1| 370|Homo sapiens POLE protein protein. 143 4e-34
BC007599-1|AAH07599.1| 797|Homo sapiens Unknown (protein for IM... 143 4e-34
AY273166-1|AAP12650.1| 2265|Homo sapiens polymerase (DNA directe... 143 4e-34
AK025087-1|BAB15063.1| 370|Homo sapiens protein ( Homo sapiens ... 143 4e-34
S60080-1|AAA15448.1| 2257|Homo sapiens DNA polymerase epsilon ca... 143 5e-34
L09561-1|AAC19148.1| 2286|Homo sapiens DNA polymerase epsilon, c... 143 5e-34
AF127975-3|AAD44692.1| 2243|Homo sapiens DNA polymerase epsilon ... 143 5e-34
AF127975-2|AAD44691.1| 2286|Homo sapiens DNA polymerase epsilon ... 143 5e-34
AF127975-1|AAD44690.1| 2297|Homo sapiens DNA polymerase epsilon ... 143 5e-34
AF110377-1|AAD04629.1| 3859|Homo sapiens PCAF-associated factor ... 31 3.2
AF076974-1|AAD09420.1| 3830|Homo sapiens TRRAP protein protein. 31 3.2
AC004893-1|AAC62433.1| 1443|Homo sapiens WUGSC:H_DJ0808A01.1 pro... 31 3.2
AB209489-1|BAD92726.1| 3587|Homo sapiens Transformation/transcri... 31 3.2
>U49356-1|AAA90924.1| 2285|Homo sapiens DNA polymerase epsilon
catalytic subunit protein.
Length = 2285
Score = 143 bits (347), Expect = 4e-34
Identities = 68/172 (39%), Positives = 100/172 (58%), Gaps = 3/172 (1%)
Frame = -3
Query: 557 VCKVFSLDPTLDEEMTLVRRNLLRLIGVGEFSSAAEWREPCAACVLTELTCRVCNHXXXX 378
VCKV SLD + ++ + R+LLRL+ VGEFS A++R+PC + VL E+ CR CN
Sbjct: 2107 VCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRSCNFCRDL 2166
Query: 377 XXXXXXXXDTER---PACLCPTCGTAYDNQEIEWRLIETMNKRTMAYTLQDLICSRCHQV 207
+ P LC C YD+ IE L+E + K+ MA+TLQDL+C +C V
Sbjct: 2167 DLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLVCLKCRGV 2226
Query: 206 KRENLSVVCDCAGDFSLMVPVTEIKDQLMTFKTIAEYYQMPLLLEQIDFNLK 51
K ++ V C CAGDF+L + +Q+ F+ IA++Y M LLE +++ L+
Sbjct: 2227 KETSMPVYCSCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQ 2278
>BC087613-1|AAH87613.1| 797|Homo sapiens POLE protein protein.
Length = 797
Score = 143 bits (347), Expect = 4e-34
Identities = 68/172 (39%), Positives = 100/172 (58%), Gaps = 3/172 (1%)
Frame = -3
Query: 557 VCKVFSLDPTLDEEMTLVRRNLLRLIGVGEFSSAAEWREPCAACVLTELTCRVCNHXXXX 378
VCKV SLD + ++ + R+LLRL+ VGEFS A++R+PC + VL E+ CR CN
Sbjct: 619 VCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRSCNFCRDL 678
Query: 377 XXXXXXXXDTER---PACLCPTCGTAYDNQEIEWRLIETMNKRTMAYTLQDLICSRCHQV 207
+ P LC C YD+ IE L+E + K+ MA+TLQDL+C +C V
Sbjct: 679 DLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLVCLKCRGV 738
Query: 206 KRENLSVVCDCAGDFSLMVPVTEIKDQLMTFKTIAEYYQMPLLLEQIDFNLK 51
K ++ V C CAGDF+L + +Q+ F+ IA++Y M LLE +++ L+
Sbjct: 739 KETSMPVYCSCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQ 790
>BC021559-1|AAH21559.1| 370|Homo sapiens POLE protein protein.
Length = 370
Score = 143 bits (347), Expect = 4e-34
Identities = 68/172 (39%), Positives = 100/172 (58%), Gaps = 3/172 (1%)
Frame = -3
Query: 557 VCKVFSLDPTLDEEMTLVRRNLLRLIGVGEFSSAAEWREPCAACVLTELTCRVCNHXXXX 378
VCKV SLD + ++ + R+LLRL+ VGEFS A++R+PC + VL E+ CR CN
Sbjct: 192 VCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRSCNFCRDL 251
Query: 377 XXXXXXXXDTER---PACLCPTCGTAYDNQEIEWRLIETMNKRTMAYTLQDLICSRCHQV 207
+ P LC C YD+ IE L+E + K+ MA+TLQDL+C +C V
Sbjct: 252 DLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLVCLKCRGV 311
Query: 206 KRENLSVVCDCAGDFSLMVPVTEIKDQLMTFKTIAEYYQMPLLLEQIDFNLK 51
K ++ V C CAGDF+L + +Q+ F+ IA++Y M LLE +++ L+
Sbjct: 312 KETSMPVYCSCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQ 363
>BC007599-1|AAH07599.1| 797|Homo sapiens Unknown (protein for
IMAGE:3347229) protein.
Length = 797
Score = 143 bits (347), Expect = 4e-34
Identities = 68/172 (39%), Positives = 100/172 (58%), Gaps = 3/172 (1%)
Frame = -3
Query: 557 VCKVFSLDPTLDEEMTLVRRNLLRLIGVGEFSSAAEWREPCAACVLTELTCRVCNHXXXX 378
VCKV SLD + ++ + R+LLRL+ VGEFS A++R+PC + VL E+ CR CN
Sbjct: 619 VCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRSCNFCRDL 678
Query: 377 XXXXXXXXDTER---PACLCPTCGTAYDNQEIEWRLIETMNKRTMAYTLQDLICSRCHQV 207
+ P LC C YD+ IE L+E + K+ MA+TLQDL+C +C V
Sbjct: 679 DLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLVCLKCRGV 738
Query: 206 KRENLSVVCDCAGDFSLMVPVTEIKDQLMTFKTIAEYYQMPLLLEQIDFNLK 51
K ++ V C CAGDF+L + +Q+ F+ IA++Y M LLE +++ L+
Sbjct: 739 KETSMPVYCSCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQ 790
>AY273166-1|AAP12650.1| 2265|Homo sapiens polymerase (DNA directed),
epsilon protein.
Length = 2265
Score = 143 bits (347), Expect = 4e-34
Identities = 68/172 (39%), Positives = 100/172 (58%), Gaps = 3/172 (1%)
Frame = -3
Query: 557 VCKVFSLDPTLDEEMTLVRRNLLRLIGVGEFSSAAEWREPCAACVLTELTCRVCNHXXXX 378
VCKV SLD + ++ + R+LLRL+ VGEFS A++R+PC + VL E+ CR CN
Sbjct: 2087 VCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRSCNFCRDL 2146
Query: 377 XXXXXXXXDTER---PACLCPTCGTAYDNQEIEWRLIETMNKRTMAYTLQDLICSRCHQV 207
+ P LC C YD+ IE L+E + K+ MA+TLQDL+C +C V
Sbjct: 2147 DLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLVCLKCRGV 2206
Query: 206 KRENLSVVCDCAGDFSLMVPVTEIKDQLMTFKTIAEYYQMPLLLEQIDFNLK 51
K ++ V C CAGDF+L + +Q+ F+ IA++Y M LLE +++ L+
Sbjct: 2207 KETSMPVYCSCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQ 2258
>AK025087-1|BAB15063.1| 370|Homo sapiens protein ( Homo sapiens
cDNA: FLJ21434 fis, clone COL04242. ).
Length = 370
Score = 143 bits (347), Expect = 4e-34
Identities = 68/172 (39%), Positives = 100/172 (58%), Gaps = 3/172 (1%)
Frame = -3
Query: 557 VCKVFSLDPTLDEEMTLVRRNLLRLIGVGEFSSAAEWREPCAACVLTELTCRVCNHXXXX 378
VCKV SLD + ++ + R+LLRL+ VGEFS A++R+PC + VL E+ CR CN
Sbjct: 192 VCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRSCNFCRDL 251
Query: 377 XXXXXXXXDTER---PACLCPTCGTAYDNQEIEWRLIETMNKRTMAYTLQDLICSRCHQV 207
+ P LC C YD+ IE L+E + K+ MA+TLQDL+C +C V
Sbjct: 252 DLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLVCLKCRGV 311
Query: 206 KRENLSVVCDCAGDFSLMVPVTEIKDQLMTFKTIAEYYQMPLLLEQIDFNLK 51
K ++ V C CAGDF+L + +Q+ F+ IA++Y M LLE +++ L+
Sbjct: 312 KETSMPVYCSCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQ 363
>S60080-1|AAA15448.1| 2257|Homo sapiens DNA polymerase epsilon
catalytic subunit protein.
Length = 2257
Score = 143 bits (346), Expect = 5e-34
Identities = 68/172 (39%), Positives = 100/172 (58%), Gaps = 3/172 (1%)
Frame = -3
Query: 557 VCKVFSLDPTLDEEMTLVRRNLLRLIGVGEFSSAAEWREPCAACVLTELTCRVCNHXXXX 378
VCKV SLD + ++ + R+LLRL+ VGEFS A++R+PC + VL E+ CR CN
Sbjct: 2079 VCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRSCNFCRDL 2138
Query: 377 XXXXXXXXDTER---PACLCPTCGTAYDNQEIEWRLIETMNKRTMAYTLQDLICSRCHQV 207
+ P LC C YD+ IE L+E + K+ MA+TLQDL+C +C V
Sbjct: 2139 DLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLVCLKCRGV 2198
Query: 206 KRENLSVVCDCAGDFSLMVPVTEIKDQLMTFKTIAEYYQMPLLLEQIDFNLK 51
K ++ V C CAGDF+L + +Q+ F+ IA++Y M LLE +++ L+
Sbjct: 2199 KETSMPVYCTCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQ 2250
>L09561-1|AAC19148.1| 2286|Homo sapiens DNA polymerase epsilon,
catalytic polypeptide protein.
Length = 2286
Score = 143 bits (346), Expect = 5e-34
Identities = 68/172 (39%), Positives = 100/172 (58%), Gaps = 3/172 (1%)
Frame = -3
Query: 557 VCKVFSLDPTLDEEMTLVRRNLLRLIGVGEFSSAAEWREPCAACVLTELTCRVCNHXXXX 378
VCKV SLD + ++ + R+LLRL+ VGEFS A++R+PC + VL E+ CR CN
Sbjct: 2108 VCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRSCNFCRDL 2167
Query: 377 XXXXXXXXDTER---PACLCPTCGTAYDNQEIEWRLIETMNKRTMAYTLQDLICSRCHQV 207
+ P LC C YD+ IE L+E + K+ MA+TLQDL+C +C V
Sbjct: 2168 DLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLVCLKCRGV 2227
Query: 206 KRENLSVVCDCAGDFSLMVPVTEIKDQLMTFKTIAEYYQMPLLLEQIDFNLK 51
K ++ V C CAGDF+L + +Q+ F+ IA++Y M LLE +++ L+
Sbjct: 2228 KETSMPVYCTCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQ 2279
>AF127975-3|AAD44692.1| 2243|Homo sapiens DNA polymerase epsilon
catalytic subunit protein isoform c protein.
Length = 2243
Score = 143 bits (346), Expect = 5e-34
Identities = 68/172 (39%), Positives = 100/172 (58%), Gaps = 3/172 (1%)
Frame = -3
Query: 557 VCKVFSLDPTLDEEMTLVRRNLLRLIGVGEFSSAAEWREPCAACVLTELTCRVCNHXXXX 378
VCKV SLD + ++ + R+LLRL+ VGEFS A++R+PC + VL E+ CR CN
Sbjct: 2065 VCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRSCNFCRDL 2124
Query: 377 XXXXXXXXDTER---PACLCPTCGTAYDNQEIEWRLIETMNKRTMAYTLQDLICSRCHQV 207
+ P LC C YD+ IE L+E + K+ MA+TLQDL+C +C V
Sbjct: 2125 DLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLVCLKCRGV 2184
Query: 206 KRENLSVVCDCAGDFSLMVPVTEIKDQLMTFKTIAEYYQMPLLLEQIDFNLK 51
K ++ V C CAGDF+L + +Q+ F+ IA++Y M LLE +++ L+
Sbjct: 2185 KETSMPVYCTCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQ 2236
>AF127975-2|AAD44691.1| 2286|Homo sapiens DNA polymerase epsilon
catalytic subunit protein isoform b protein.
Length = 2286
Score = 143 bits (346), Expect = 5e-34
Identities = 68/172 (39%), Positives = 100/172 (58%), Gaps = 3/172 (1%)
Frame = -3
Query: 557 VCKVFSLDPTLDEEMTLVRRNLLRLIGVGEFSSAAEWREPCAACVLTELTCRVCNHXXXX 378
VCKV SLD + ++ + R+LLRL+ VGEFS A++R+PC + VL E+ CR CN
Sbjct: 2108 VCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRSCNFCRDL 2167
Query: 377 XXXXXXXXDTER---PACLCPTCGTAYDNQEIEWRLIETMNKRTMAYTLQDLICSRCHQV 207
+ P LC C YD+ IE L+E + K+ MA+TLQDL+C +C V
Sbjct: 2168 DLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLVCLKCRGV 2227
Query: 206 KRENLSVVCDCAGDFSLMVPVTEIKDQLMTFKTIAEYYQMPLLLEQIDFNLK 51
K ++ V C CAGDF+L + +Q+ F+ IA++Y M LLE +++ L+
Sbjct: 2228 KETSMPVYCTCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQ 2279
>AF127975-1|AAD44690.1| 2297|Homo sapiens DNA polymerase epsilon
catalytic subunit protein isoform a protein.
Length = 2297
Score = 143 bits (346), Expect = 5e-34
Identities = 68/172 (39%), Positives = 100/172 (58%), Gaps = 3/172 (1%)
Frame = -3
Query: 557 VCKVFSLDPTLDEEMTLVRRNLLRLIGVGEFSSAAEWREPCAACVLTELTCRVCNHXXXX 378
VCKV SLD + ++ + R+LLRL+ VGEFS A++R+PC + VL E+ CR CN
Sbjct: 2119 VCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRSCNFCRDL 2178
Query: 377 XXXXXXXXDTER---PACLCPTCGTAYDNQEIEWRLIETMNKRTMAYTLQDLICSRCHQV 207
+ P LC C YD+ IE L+E + K+ MA+TLQDL+C +C V
Sbjct: 2179 DLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLVCLKCRGV 2238
Query: 206 KRENLSVVCDCAGDFSLMVPVTEIKDQLMTFKTIAEYYQMPLLLEQIDFNLK 51
K ++ V C CAGDF+L + +Q+ F+ IA++Y M LLE +++ L+
Sbjct: 2239 KETSMPVYCTCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQ 2290
>AF110377-1|AAD04629.1| 3859|Homo sapiens PCAF-associated factor 400
protein.
Length = 3859
Score = 31.1 bits (67), Expect = 3.2
Identities = 19/79 (24%), Positives = 38/79 (48%), Gaps = 3/79 (3%)
Frame = -3
Query: 287 WRLIETMNKRTMAYTLQDLICSRCHQVKRENLSVVCDCAGD-FSLMVPVTEIKDQLMTF- 114
W+++ + +A + +CS HQV+R+ +C + S VP I+ ++ +
Sbjct: 2637 WKILSDRQQHALAGEISPFLCSGSHQVQRDCQPSALNCFVEAMSQCVPPIPIRPCVLKYL 2696
Query: 113 -KTIAEYYQMPLLLEQIDF 60
KT +++ L+LE F
Sbjct: 2697 GKTHNLWFRSTLMLEHQAF 2715
>AF076974-1|AAD09420.1| 3830|Homo sapiens TRRAP protein protein.
Length = 3830
Score = 31.1 bits (67), Expect = 3.2
Identities = 19/79 (24%), Positives = 38/79 (48%), Gaps = 3/79 (3%)
Frame = -3
Query: 287 WRLIETMNKRTMAYTLQDLICSRCHQVKRENLSVVCDCAGD-FSLMVPVTEIKDQLMTF- 114
W+++ + +A + +CS HQV+R+ +C + S VP I+ ++ +
Sbjct: 2619 WKILSDRQQHALAGEISPFLCSGSHQVQRDCQPSALNCFVEAMSQCVPPIPIRPCVLKYL 2678
Query: 113 -KTIAEYYQMPLLLEQIDF 60
KT +++ L+LE F
Sbjct: 2679 GKTHNLWFRSTLMLEHQAF 2697
>AC004893-1|AAC62433.1| 1443|Homo sapiens WUGSC:H_DJ0808A01.1
protein.
Length = 1443
Score = 31.1 bits (67), Expect = 3.2
Identities = 19/79 (24%), Positives = 38/79 (48%), Gaps = 3/79 (3%)
Frame = -3
Query: 287 WRLIETMNKRTMAYTLQDLICSRCHQVKRENLSVVCDCAGD-FSLMVPVTEIKDQLMTF- 114
W+++ + +A + +CS HQV+R+ +C + S VP I+ ++ +
Sbjct: 360 WKILSDRQQHALAGEISPFLCSGSHQVQRDCQPSALNCFVEAMSQCVPPIPIRPCVLKYL 419
Query: 113 -KTIAEYYQMPLLLEQIDF 60
KT +++ L+LE F
Sbjct: 420 GKTHNLWFRSTLMLEHQAF 438
>AB209489-1|BAD92726.1| 3587|Homo sapiens Transformation/transcription
domain-associated protein variant protein.
Length = 3587
Score = 31.1 bits (67), Expect = 3.2
Identities = 19/79 (24%), Positives = 38/79 (48%), Gaps = 3/79 (3%)
Frame = -3
Query: 287 WRLIETMNKRTMAYTLQDLICSRCHQVKRENLSVVCDCAGD-FSLMVPVTEIKDQLMTF- 114
W+++ + +A + +CS HQV+R+ +C + S VP I+ ++ +
Sbjct: 2358 WKILSDRQQHALAGEISPFLCSGSHQVQRDCQPSALNCFVEAMSQCVPPIPIRPCVLKYL 2417
Query: 113 -KTIAEYYQMPLLLEQIDF 60
KT +++ L+LE F
Sbjct: 2418 GKTHNLWFRSTLMLEHQAF 2436
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 79,679,479
Number of Sequences: 237096
Number of extensions: 1571037
Number of successful extensions: 3915
Number of sequences better than 10.0: 15
Number of HSP's better than 10.0 without gapping: 3716
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3904
length of database: 76,859,062
effective HSP length: 87
effective length of database: 56,231,710
effective search space used: 6466646650
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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