Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= ceN-2228
(729 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
U49356-1|AAA90924.1| 2285|Homo sapiens DNA polymerase epsilon ca... 147 3e-35
BC087613-1|AAH87613.1| 797|Homo sapiens POLE protein protein. 147 3e-35
BC021559-1|AAH21559.1| 370|Homo sapiens POLE protein protein. 147 3e-35
BC007599-1|AAH07599.1| 797|Homo sapiens Unknown (protein for IM... 147 3e-35
AY273166-1|AAP12650.1| 2265|Homo sapiens polymerase (DNA directe... 147 3e-35
AK025087-1|BAB15063.1| 370|Homo sapiens protein ( Homo sapiens ... 147 3e-35
S60080-1|AAA15448.1| 2257|Homo sapiens DNA polymerase epsilon ca... 147 4e-35
L09561-1|AAC19148.1| 2286|Homo sapiens DNA polymerase epsilon, c... 147 4e-35
AF127975-3|AAD44692.1| 2243|Homo sapiens DNA polymerase epsilon ... 147 4e-35
AF127975-2|AAD44691.1| 2286|Homo sapiens DNA polymerase epsilon ... 147 4e-35
AF127975-1|AAD44690.1| 2297|Homo sapiens DNA polymerase epsilon ... 147 4e-35
AF110377-1|AAD04629.1| 3859|Homo sapiens PCAF-associated factor ... 31 4.2
AF076974-1|AAD09420.1| 3830|Homo sapiens TRRAP protein protein. 31 4.2
AC004893-1|AAC62433.1| 1443|Homo sapiens WUGSC:H_DJ0808A01.1 pro... 31 4.2
AB209489-1|BAD92726.1| 3587|Homo sapiens Transformation/transcri... 31 4.2
>U49356-1|AAA90924.1| 2285|Homo sapiens DNA polymerase epsilon
catalytic subunit protein.
Length = 2285
Score = 147 bits (357), Expect = 3e-35
Identities = 70/180 (38%), Positives = 103/180 (57%), Gaps = 3/180 (1%)
Frame = -2
Query: 581 PGPPFVNAVCKVFSLDPTLDEEMTLVRRNLLRLIGVGEFSSAAEWREPCAACVLTELTCR 402
P F+ VCKV SLD + ++ + R+LLRL+ VGEFS A++R+PC + VL E+ CR
Sbjct: 2099 PALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICR 2158
Query: 401 VCNHXXXXXXXXXXXXDTER---PACLCPTCGTAYDNQEIEWRLIETMNKRTMAYTLQDL 231
CN + P LC C YD+ IE L+E + K+ MA+TLQDL
Sbjct: 2159 SCNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDL 2218
Query: 230 ICSRCHQVKRENLSVVCDCAGDFSLMVPVTEIKDQLMTFKTIAEYYQMPLLLEQIDFNLK 51
+C +C VK ++ V C CAGDF+L + +Q+ F+ IA++Y M LLE +++ L+
Sbjct: 2219 VCLKCRGVKETSMPVYCSCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQ 2278
>BC087613-1|AAH87613.1| 797|Homo sapiens POLE protein protein.
Length = 797
Score = 147 bits (357), Expect = 3e-35
Identities = 70/180 (38%), Positives = 103/180 (57%), Gaps = 3/180 (1%)
Frame = -2
Query: 581 PGPPFVNAVCKVFSLDPTLDEEMTLVRRNLLRLIGVGEFSSAAEWREPCAACVLTELTCR 402
P F+ VCKV SLD + ++ + R+LLRL+ VGEFS A++R+PC + VL E+ CR
Sbjct: 611 PALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICR 670
Query: 401 VCNHXXXXXXXXXXXXDTER---PACLCPTCGTAYDNQEIEWRLIETMNKRTMAYTLQDL 231
CN + P LC C YD+ IE L+E + K+ MA+TLQDL
Sbjct: 671 SCNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDL 730
Query: 230 ICSRCHQVKRENLSVVCDCAGDFSLMVPVTEIKDQLMTFKTIAEYYQMPLLLEQIDFNLK 51
+C +C VK ++ V C CAGDF+L + +Q+ F+ IA++Y M LLE +++ L+
Sbjct: 731 VCLKCRGVKETSMPVYCSCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQ 790
>BC021559-1|AAH21559.1| 370|Homo sapiens POLE protein protein.
Length = 370
Score = 147 bits (357), Expect = 3e-35
Identities = 70/180 (38%), Positives = 103/180 (57%), Gaps = 3/180 (1%)
Frame = -2
Query: 581 PGPPFVNAVCKVFSLDPTLDEEMTLVRRNLLRLIGVGEFSSAAEWREPCAACVLTELTCR 402
P F+ VCKV SLD + ++ + R+LLRL+ VGEFS A++R+PC + VL E+ CR
Sbjct: 184 PALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICR 243
Query: 401 VCNHXXXXXXXXXXXXDTER---PACLCPTCGTAYDNQEIEWRLIETMNKRTMAYTLQDL 231
CN + P LC C YD+ IE L+E + K+ MA+TLQDL
Sbjct: 244 SCNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDL 303
Query: 230 ICSRCHQVKRENLSVVCDCAGDFSLMVPVTEIKDQLMTFKTIAEYYQMPLLLEQIDFNLK 51
+C +C VK ++ V C CAGDF+L + +Q+ F+ IA++Y M LLE +++ L+
Sbjct: 304 VCLKCRGVKETSMPVYCSCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQ 363
>BC007599-1|AAH07599.1| 797|Homo sapiens Unknown (protein for
IMAGE:3347229) protein.
Length = 797
Score = 147 bits (357), Expect = 3e-35
Identities = 70/180 (38%), Positives = 103/180 (57%), Gaps = 3/180 (1%)
Frame = -2
Query: 581 PGPPFVNAVCKVFSLDPTLDEEMTLVRRNLLRLIGVGEFSSAAEWREPCAACVLTELTCR 402
P F+ VCKV SLD + ++ + R+LLRL+ VGEFS A++R+PC + VL E+ CR
Sbjct: 611 PALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICR 670
Query: 401 VCNHXXXXXXXXXXXXDTER---PACLCPTCGTAYDNQEIEWRLIETMNKRTMAYTLQDL 231
CN + P LC C YD+ IE L+E + K+ MA+TLQDL
Sbjct: 671 SCNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDL 730
Query: 230 ICSRCHQVKRENLSVVCDCAGDFSLMVPVTEIKDQLMTFKTIAEYYQMPLLLEQIDFNLK 51
+C +C VK ++ V C CAGDF+L + +Q+ F+ IA++Y M LLE +++ L+
Sbjct: 731 VCLKCRGVKETSMPVYCSCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQ 790
>AY273166-1|AAP12650.1| 2265|Homo sapiens polymerase (DNA directed),
epsilon protein.
Length = 2265
Score = 147 bits (357), Expect = 3e-35
Identities = 70/180 (38%), Positives = 103/180 (57%), Gaps = 3/180 (1%)
Frame = -2
Query: 581 PGPPFVNAVCKVFSLDPTLDEEMTLVRRNLLRLIGVGEFSSAAEWREPCAACVLTELTCR 402
P F+ VCKV SLD + ++ + R+LLRL+ VGEFS A++R+PC + VL E+ CR
Sbjct: 2079 PALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICR 2138
Query: 401 VCNHXXXXXXXXXXXXDTER---PACLCPTCGTAYDNQEIEWRLIETMNKRTMAYTLQDL 231
CN + P LC C YD+ IE L+E + K+ MA+TLQDL
Sbjct: 2139 SCNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDL 2198
Query: 230 ICSRCHQVKRENLSVVCDCAGDFSLMVPVTEIKDQLMTFKTIAEYYQMPLLLEQIDFNLK 51
+C +C VK ++ V C CAGDF+L + +Q+ F+ IA++Y M LLE +++ L+
Sbjct: 2199 VCLKCRGVKETSMPVYCSCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQ 2258
>AK025087-1|BAB15063.1| 370|Homo sapiens protein ( Homo sapiens
cDNA: FLJ21434 fis, clone COL04242. ).
Length = 370
Score = 147 bits (357), Expect = 3e-35
Identities = 70/180 (38%), Positives = 103/180 (57%), Gaps = 3/180 (1%)
Frame = -2
Query: 581 PGPPFVNAVCKVFSLDPTLDEEMTLVRRNLLRLIGVGEFSSAAEWREPCAACVLTELTCR 402
P F+ VCKV SLD + ++ + R+LLRL+ VGEFS A++R+PC + VL E+ CR
Sbjct: 184 PALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICR 243
Query: 401 VCNHXXXXXXXXXXXXDTER---PACLCPTCGTAYDNQEIEWRLIETMNKRTMAYTLQDL 231
CN + P LC C YD+ IE L+E + K+ MA+TLQDL
Sbjct: 244 SCNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDL 303
Query: 230 ICSRCHQVKRENLSVVCDCAGDFSLMVPVTEIKDQLMTFKTIAEYYQMPLLLEQIDFNLK 51
+C +C VK ++ V C CAGDF+L + +Q+ F+ IA++Y M LLE +++ L+
Sbjct: 304 VCLKCRGVKETSMPVYCSCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQ 363
>S60080-1|AAA15448.1| 2257|Homo sapiens DNA polymerase epsilon
catalytic subunit protein.
Length = 2257
Score = 147 bits (356), Expect = 4e-35
Identities = 70/180 (38%), Positives = 103/180 (57%), Gaps = 3/180 (1%)
Frame = -2
Query: 581 PGPPFVNAVCKVFSLDPTLDEEMTLVRRNLLRLIGVGEFSSAAEWREPCAACVLTELTCR 402
P F+ VCKV SLD + ++ + R+LLRL+ VGEFS A++R+PC + VL E+ CR
Sbjct: 2071 PALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICR 2130
Query: 401 VCNHXXXXXXXXXXXXDTER---PACLCPTCGTAYDNQEIEWRLIETMNKRTMAYTLQDL 231
CN + P LC C YD+ IE L+E + K+ MA+TLQDL
Sbjct: 2131 SCNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDL 2190
Query: 230 ICSRCHQVKRENLSVVCDCAGDFSLMVPVTEIKDQLMTFKTIAEYYQMPLLLEQIDFNLK 51
+C +C VK ++ V C CAGDF+L + +Q+ F+ IA++Y M LLE +++ L+
Sbjct: 2191 VCLKCRGVKETSMPVYCTCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQ 2250
>L09561-1|AAC19148.1| 2286|Homo sapiens DNA polymerase epsilon,
catalytic polypeptide protein.
Length = 2286
Score = 147 bits (356), Expect = 4e-35
Identities = 70/180 (38%), Positives = 103/180 (57%), Gaps = 3/180 (1%)
Frame = -2
Query: 581 PGPPFVNAVCKVFSLDPTLDEEMTLVRRNLLRLIGVGEFSSAAEWREPCAACVLTELTCR 402
P F+ VCKV SLD + ++ + R+LLRL+ VGEFS A++R+PC + VL E+ CR
Sbjct: 2100 PALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICR 2159
Query: 401 VCNHXXXXXXXXXXXXDTER---PACLCPTCGTAYDNQEIEWRLIETMNKRTMAYTLQDL 231
CN + P LC C YD+ IE L+E + K+ MA+TLQDL
Sbjct: 2160 SCNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDL 2219
Query: 230 ICSRCHQVKRENLSVVCDCAGDFSLMVPVTEIKDQLMTFKTIAEYYQMPLLLEQIDFNLK 51
+C +C VK ++ V C CAGDF+L + +Q+ F+ IA++Y M LLE +++ L+
Sbjct: 2220 VCLKCRGVKETSMPVYCTCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQ 2279
>AF127975-3|AAD44692.1| 2243|Homo sapiens DNA polymerase epsilon
catalytic subunit protein isoform c protein.
Length = 2243
Score = 147 bits (356), Expect = 4e-35
Identities = 70/180 (38%), Positives = 103/180 (57%), Gaps = 3/180 (1%)
Frame = -2
Query: 581 PGPPFVNAVCKVFSLDPTLDEEMTLVRRNLLRLIGVGEFSSAAEWREPCAACVLTELTCR 402
P F+ VCKV SLD + ++ + R+LLRL+ VGEFS A++R+PC + VL E+ CR
Sbjct: 2057 PALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICR 2116
Query: 401 VCNHXXXXXXXXXXXXDTER---PACLCPTCGTAYDNQEIEWRLIETMNKRTMAYTLQDL 231
CN + P LC C YD+ IE L+E + K+ MA+TLQDL
Sbjct: 2117 SCNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDL 2176
Query: 230 ICSRCHQVKRENLSVVCDCAGDFSLMVPVTEIKDQLMTFKTIAEYYQMPLLLEQIDFNLK 51
+C +C VK ++ V C CAGDF+L + +Q+ F+ IA++Y M LLE +++ L+
Sbjct: 2177 VCLKCRGVKETSMPVYCTCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQ 2236
>AF127975-2|AAD44691.1| 2286|Homo sapiens DNA polymerase epsilon
catalytic subunit protein isoform b protein.
Length = 2286
Score = 147 bits (356), Expect = 4e-35
Identities = 70/180 (38%), Positives = 103/180 (57%), Gaps = 3/180 (1%)
Frame = -2
Query: 581 PGPPFVNAVCKVFSLDPTLDEEMTLVRRNLLRLIGVGEFSSAAEWREPCAACVLTELTCR 402
P F+ VCKV SLD + ++ + R+LLRL+ VGEFS A++R+PC + VL E+ CR
Sbjct: 2100 PALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICR 2159
Query: 401 VCNHXXXXXXXXXXXXDTER---PACLCPTCGTAYDNQEIEWRLIETMNKRTMAYTLQDL 231
CN + P LC C YD+ IE L+E + K+ MA+TLQDL
Sbjct: 2160 SCNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDL 2219
Query: 230 ICSRCHQVKRENLSVVCDCAGDFSLMVPVTEIKDQLMTFKTIAEYYQMPLLLEQIDFNLK 51
+C +C VK ++ V C CAGDF+L + +Q+ F+ IA++Y M LLE +++ L+
Sbjct: 2220 VCLKCRGVKETSMPVYCTCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQ 2279
>AF127975-1|AAD44690.1| 2297|Homo sapiens DNA polymerase epsilon
catalytic subunit protein isoform a protein.
Length = 2297
Score = 147 bits (356), Expect = 4e-35
Identities = 70/180 (38%), Positives = 103/180 (57%), Gaps = 3/180 (1%)
Frame = -2
Query: 581 PGPPFVNAVCKVFSLDPTLDEEMTLVRRNLLRLIGVGEFSSAAEWREPCAACVLTELTCR 402
P F+ VCKV SLD + ++ + R+LLRL+ VGEFS A++R+PC + VL E+ CR
Sbjct: 2111 PALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICR 2170
Query: 401 VCNHXXXXXXXXXXXXDTER---PACLCPTCGTAYDNQEIEWRLIETMNKRTMAYTLQDL 231
CN + P LC C YD+ IE L+E + K+ MA+TLQDL
Sbjct: 2171 SCNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDL 2230
Query: 230 ICSRCHQVKRENLSVVCDCAGDFSLMVPVTEIKDQLMTFKTIAEYYQMPLLLEQIDFNLK 51
+C +C VK ++ V C CAGDF+L + +Q+ F+ IA++Y M LLE +++ L+
Sbjct: 2231 VCLKCRGVKETSMPVYCTCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQ 2290
>AF110377-1|AAD04629.1| 3859|Homo sapiens PCAF-associated factor 400
protein.
Length = 3859
Score = 31.1 bits (67), Expect = 4.2
Identities = 19/79 (24%), Positives = 38/79 (48%), Gaps = 3/79 (3%)
Frame = -2
Query: 287 WRLIETMNKRTMAYTLQDLICSRCHQVKRENLSVVCDCAGD-FSLMVPVTEIKDQLMTF- 114
W+++ + +A + +CS HQV+R+ +C + S VP I+ ++ +
Sbjct: 2637 WKILSDRQQHALAGEISPFLCSGSHQVQRDCQPSALNCFVEAMSQCVPPIPIRPCVLKYL 2696
Query: 113 -KTIAEYYQMPLLLEQIDF 60
KT +++ L+LE F
Sbjct: 2697 GKTHNLWFRSTLMLEHQAF 2715
>AF076974-1|AAD09420.1| 3830|Homo sapiens TRRAP protein protein.
Length = 3830
Score = 31.1 bits (67), Expect = 4.2
Identities = 19/79 (24%), Positives = 38/79 (48%), Gaps = 3/79 (3%)
Frame = -2
Query: 287 WRLIETMNKRTMAYTLQDLICSRCHQVKRENLSVVCDCAGD-FSLMVPVTEIKDQLMTF- 114
W+++ + +A + +CS HQV+R+ +C + S VP I+ ++ +
Sbjct: 2619 WKILSDRQQHALAGEISPFLCSGSHQVQRDCQPSALNCFVEAMSQCVPPIPIRPCVLKYL 2678
Query: 113 -KTIAEYYQMPLLLEQIDF 60
KT +++ L+LE F
Sbjct: 2679 GKTHNLWFRSTLMLEHQAF 2697
>AC004893-1|AAC62433.1| 1443|Homo sapiens WUGSC:H_DJ0808A01.1
protein.
Length = 1443
Score = 31.1 bits (67), Expect = 4.2
Identities = 19/79 (24%), Positives = 38/79 (48%), Gaps = 3/79 (3%)
Frame = -2
Query: 287 WRLIETMNKRTMAYTLQDLICSRCHQVKRENLSVVCDCAGD-FSLMVPVTEIKDQLMTF- 114
W+++ + +A + +CS HQV+R+ +C + S VP I+ ++ +
Sbjct: 360 WKILSDRQQHALAGEISPFLCSGSHQVQRDCQPSALNCFVEAMSQCVPPIPIRPCVLKYL 419
Query: 113 -KTIAEYYQMPLLLEQIDF 60
KT +++ L+LE F
Sbjct: 420 GKTHNLWFRSTLMLEHQAF 438
>AB209489-1|BAD92726.1| 3587|Homo sapiens Transformation/transcription
domain-associated protein variant protein.
Length = 3587
Score = 31.1 bits (67), Expect = 4.2
Identities = 19/79 (24%), Positives = 38/79 (48%), Gaps = 3/79 (3%)
Frame = -2
Query: 287 WRLIETMNKRTMAYTLQDLICSRCHQVKRENLSVVCDCAGD-FSLMVPVTEIKDQLMTF- 114
W+++ + +A + +CS HQV+R+ +C + S VP I+ ++ +
Sbjct: 2358 WKILSDRQQHALAGEISPFLCSGSHQVQRDCQPSALNCFVEAMSQCVPPIPIRPCVLKYL 2417
Query: 113 -KTIAEYYQMPLLLEQIDF 60
KT +++ L+LE F
Sbjct: 2418 GKTHNLWFRSTLMLEHQAF 2436
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 96,151,009
Number of Sequences: 237096
Number of extensions: 1957061
Number of successful extensions: 4349
Number of sequences better than 10.0: 15
Number of HSP's better than 10.0 without gapping: 4182
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4338
length of database: 76,859,062
effective HSP length: 88
effective length of database: 55,994,614
effective search space used: 8623170556
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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