Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= ceN-0841
(629 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
CR541695-1|CAG46496.1| 414|Homo sapiens IDH1 protein. 260 4e-69
CR536499-1|CAG38738.1| 414|Homo sapiens IDH1 protein. 260 4e-69
BX537411-1|CAD97653.1| 414|Homo sapiens hypothetical protein pr... 260 4e-69
BC093020-1|AAH93020.1| 414|Homo sapiens isocitrate dehydrogenas... 260 4e-69
BC012846-1|AAH12846.1| 414|Homo sapiens IDH1 protein protein. 260 4e-69
AF113917-1|AAD29284.1| 414|Homo sapiens NADP+-dependent isocitr... 260 4e-69
AF020038-1|AAD02918.1| 414|Homo sapiens NADP-dependent isocitra... 260 4e-69
AC016697-3|AAX93221.1| 414|Homo sapiens unknown protein. 260 4e-69
CR533522-1|CAG38553.1| 414|Homo sapiens IDH1 protein. 259 7e-69
X69433-1|CAA49208.1| 452|Homo sapiens isocitrate dehydrogenase... 241 1e-63
BC071828-1|AAH71828.1| 452|Homo sapiens isocitrate dehydrogenas... 241 1e-63
BC009244-1|AAH09244.1| 452|Homo sapiens isocitrate dehydrogenas... 241 1e-63
AK222916-1|BAD96636.1| 452|Homo sapiens isocitrate dehydrogenas... 241 1e-63
DQ403082-1|ABD77215.1| 371|Homo sapiens isocitrate dehydrogenas... 220 4e-57
U52144-1|AAC50455.1| 419|Homo sapiens isocitrate dehydrogenase ... 196 4e-50
U62389-1|AAB17375.1| 154|Homo sapiens putative cytosolic NADP-d... 95 2e-19
>CR541695-1|CAG46496.1| 414|Homo sapiens IDH1 protein.
Length = 414
Score = 260 bits (636), Expect = 4e-69
Identities = 117/144 (81%), Positives = 133/144 (92%)
Frame = +3
Query: 198 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 377
KI G VV++ GDEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 378 IKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTG 557
IKK+NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+G
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSG 123
Query: 558 WDKPIIIGRHAHADQYKATDFVVP 629
W KPIIIGRHA+ DQY+ATDFVVP
Sbjct: 124 WVKPIIIGRHAYGDQYRATDFVVP 147
>CR536499-1|CAG38738.1| 414|Homo sapiens IDH1 protein.
Length = 414
Score = 260 bits (636), Expect = 4e-69
Identities = 117/144 (81%), Positives = 133/144 (92%)
Frame = +3
Query: 198 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 377
KI G VV++ GDEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 378 IKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTG 557
IKK+NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+G
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSG 123
Query: 558 WDKPIIIGRHAHADQYKATDFVVP 629
W KPIIIGRHA+ DQY+ATDFVVP
Sbjct: 124 WVKPIIIGRHAYGDQYRATDFVVP 147
>BX537411-1|CAD97653.1| 414|Homo sapiens hypothetical protein
protein.
Length = 414
Score = 260 bits (636), Expect = 4e-69
Identities = 117/144 (81%), Positives = 133/144 (92%)
Frame = +3
Query: 198 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 377
KI G VV++ GDEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 378 IKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTG 557
IKK+NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+G
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSG 123
Query: 558 WDKPIIIGRHAHADQYKATDFVVP 629
W KPIIIGRHA+ DQY+ATDFVVP
Sbjct: 124 WVKPIIIGRHAYGDQYRATDFVVP 147
>BC093020-1|AAH93020.1| 414|Homo sapiens isocitrate dehydrogenase 1
(NADP+), soluble protein.
Length = 414
Score = 260 bits (636), Expect = 4e-69
Identities = 117/144 (81%), Positives = 133/144 (92%)
Frame = +3
Query: 198 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 377
KI G VV++ GDEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 378 IKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTG 557
IKK+NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+G
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSG 123
Query: 558 WDKPIIIGRHAHADQYKATDFVVP 629
W KPIIIGRHA+ DQY+ATDFVVP
Sbjct: 124 WVKPIIIGRHAYGDQYRATDFVVP 147
>BC012846-1|AAH12846.1| 414|Homo sapiens IDH1 protein protein.
Length = 414
Score = 260 bits (636), Expect = 4e-69
Identities = 117/144 (81%), Positives = 133/144 (92%)
Frame = +3
Query: 198 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 377
KI G VV++ GDEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 378 IKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTG 557
IKK+NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+G
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSG 123
Query: 558 WDKPIIIGRHAHADQYKATDFVVP 629
W KPIIIGRHA+ DQY+ATDFVVP
Sbjct: 124 WVKPIIIGRHAYGDQYRATDFVVP 147
>AF113917-1|AAD29284.1| 414|Homo sapiens NADP+-dependent isocitrate
dehydrogenase protein.
Length = 414
Score = 260 bits (636), Expect = 4e-69
Identities = 117/144 (81%), Positives = 133/144 (92%)
Frame = +3
Query: 198 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 377
KI G VV++ GDEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 378 IKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTG 557
IKK+NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+G
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSG 123
Query: 558 WDKPIIIGRHAHADQYKATDFVVP 629
W KPIIIGRHA+ DQY+ATDFVVP
Sbjct: 124 WVKPIIIGRHAYGDQYRATDFVVP 147
>AF020038-1|AAD02918.1| 414|Homo sapiens NADP-dependent isocitrate
dehydrogenase protein.
Length = 414
Score = 260 bits (636), Expect = 4e-69
Identities = 117/144 (81%), Positives = 133/144 (92%)
Frame = +3
Query: 198 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 377
KI G VV++ GDEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 378 IKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTG 557
IKK+NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+G
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSG 123
Query: 558 WDKPIIIGRHAHADQYKATDFVVP 629
W KPIIIGRHA+ DQY+ATDFVVP
Sbjct: 124 WVKPIIIGRHAYGDQYRATDFVVP 147
>AC016697-3|AAX93221.1| 414|Homo sapiens unknown protein.
Length = 414
Score = 260 bits (636), Expect = 4e-69
Identities = 117/144 (81%), Positives = 133/144 (92%)
Frame = +3
Query: 198 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 377
KI G VV++ GDEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 378 IKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTG 557
IKK+NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+G
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSG 123
Query: 558 WDKPIIIGRHAHADQYKATDFVVP 629
W KPIIIGRHA+ DQY+ATDFVVP
Sbjct: 124 WVKPIIIGRHAYGDQYRATDFVVP 147
>CR533522-1|CAG38553.1| 414|Homo sapiens IDH1 protein.
Length = 414
Score = 259 bits (634), Expect = 7e-69
Identities = 116/144 (80%), Positives = 134/144 (93%)
Frame = +3
Query: 198 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 377
KI G VV++ GDEMTRIIW+LIKEKLI+P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIIPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 378 IKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTG 557
IKK+NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+G
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSG 123
Query: 558 WDKPIIIGRHAHADQYKATDFVVP 629
W +PIIIGRHA+ DQY+ATDFVVP
Sbjct: 124 WVEPIIIGRHAYGDQYRATDFVVP 147
>X69433-1|CAA49208.1| 452|Homo sapiens isocitrate dehydrogenase
(NADP+) protein.
Length = 452
Score = 241 bits (590), Expect = 1e-63
Identities = 114/147 (77%), Positives = 125/147 (85%), Gaps = 1/147 (0%)
Frame = +3
Query: 186 YNMSKIK-AGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTI 362
Y +IK A PVV++ GDEMTRIIW IKEKLILP +DI+L +DLG+ NRD+TDDQVTI
Sbjct: 39 YADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTI 98
Query: 363 DCAEAIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIP 542
D A A +KY+V +KCATITPDE RVEEFKLKKMWKSPNGTIRNILGGTVFRE IICKNIP
Sbjct: 99 DSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIP 158
Query: 543 RLVTGWDKPIIIGRHAHADQYKATDFV 623
RLV GW KPI IGRHAH DQYKATDFV
Sbjct: 159 RLVPGWTKPITIGRHAHGDQYKATDFV 185
>BC071828-1|AAH71828.1| 452|Homo sapiens isocitrate dehydrogenase 2
(NADP+), mitochondrial protein.
Length = 452
Score = 241 bits (590), Expect = 1e-63
Identities = 114/147 (77%), Positives = 125/147 (85%), Gaps = 1/147 (0%)
Frame = +3
Query: 186 YNMSKIK-AGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTI 362
Y +IK A PVV++ GDEMTRIIW IKEKLILP +DI+L +DLG+ NRD+TDDQVTI
Sbjct: 39 YADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTI 98
Query: 363 DCAEAIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIP 542
D A A +KY+V +KCATITPDE RVEEFKLKKMWKSPNGTIRNILGGTVFRE IICKNIP
Sbjct: 99 DSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIP 158
Query: 543 RLVTGWDKPIIIGRHAHADQYKATDFV 623
RLV GW KPI IGRHAH DQYKATDFV
Sbjct: 159 RLVPGWTKPITIGRHAHGDQYKATDFV 185
>BC009244-1|AAH09244.1| 452|Homo sapiens isocitrate dehydrogenase 2
(NADP+), mitochondrial protein.
Length = 452
Score = 241 bits (590), Expect = 1e-63
Identities = 114/147 (77%), Positives = 125/147 (85%), Gaps = 1/147 (0%)
Frame = +3
Query: 186 YNMSKIK-AGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTI 362
Y +IK A PVV++ GDEMTRIIW IKEKLILP +DI+L +DLG+ NRD+TDDQVTI
Sbjct: 39 YADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTI 98
Query: 363 DCAEAIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIP 542
D A A +KY+V +KCATITPDE RVEEFKLKKMWKSPNGTIRNILGGTVFRE IICKNIP
Sbjct: 99 DSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIP 158
Query: 543 RLVTGWDKPIIIGRHAHADQYKATDFV 623
RLV GW KPI IGRHAH DQYKATDFV
Sbjct: 159 RLVPGWTKPITIGRHAHGDQYKATDFV 185
>AK222916-1|BAD96636.1| 452|Homo sapiens isocitrate dehydrogenase 2
(NADP+), mitochondrial precursor variant protein.
Length = 452
Score = 241 bits (590), Expect = 1e-63
Identities = 114/147 (77%), Positives = 125/147 (85%), Gaps = 1/147 (0%)
Frame = +3
Query: 186 YNMSKIK-AGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTI 362
Y +IK A PVV++ GDEMTRIIW IKEKLILP +DI+L +DLG+ NRD+TDDQVTI
Sbjct: 39 YADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTI 98
Query: 363 DCAEAIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIP 542
D A A +KY+V +KCATITPDE RVEEFKLKKMWKSPNGTIRNILGGTVFRE IICKNIP
Sbjct: 99 DSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIP 158
Query: 543 RLVTGWDKPIIIGRHAHADQYKATDFV 623
RLV GW KPI IGRHAH DQYKATDFV
Sbjct: 159 RLVPGWTKPITIGRHAHGDQYKATDFV 185
>DQ403082-1|ABD77215.1| 371|Homo sapiens isocitrate dehydrogenase 1
protein.
Length = 371
Score = 220 bits (537), Expect = 4e-57
Identities = 98/118 (83%), Positives = 111/118 (94%)
Frame = +3
Query: 276 LILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFKLK 455
LI P+++++LH YDLG+ENRD T+DQVT D AEAIKK+NVG+KCATITPDEKRVEEFKLK
Sbjct: 1 LIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLK 60
Query: 456 KMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVP 629
+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW KPIIIGRHA+ DQY+ATDFVVP
Sbjct: 61 QMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVP 118
>U52144-1|AAC50455.1| 419|Homo sapiens isocitrate dehydrogenase
protein.
Length = 419
Score = 196 bits (479), Expect = 4e-50
Identities = 89/111 (80%), Positives = 97/111 (87%)
Frame = +3
Query: 291 LDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFKLKKMWKS 470
LD++L +DLG+ NRD+TDDQVTID A A +KY+V +KCATITPDE RVEEFKLKKMWKS
Sbjct: 42 LDVQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKS 101
Query: 471 PNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFV 623
PNGTIRNI GGTVFRE IICKNIPRLV GW KPI IGRHAH DQYKATDFV
Sbjct: 102 PNGTIRNIHGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFV 152
>U62389-1|AAB17375.1| 154|Homo sapiens putative cytosolic
NADP-dependent isocitrate dehydrogenase protein.
Length = 154
Score = 95.1 bits (226), Expect = 2e-19
Identities = 42/48 (87%), Positives = 45/48 (93%)
Frame = +3
Query: 486 RNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVP 629
RNILGGTVF EAIICKNIPRLV+GW KPIIIGRHA+ DQY+ATDFVVP
Sbjct: 1 RNILGGTVFXEAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVP 48
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 94,326,394
Number of Sequences: 237096
Number of extensions: 1984393
Number of successful extensions: 3389
Number of sequences better than 10.0: 16
Number of HSP's better than 10.0 without gapping: 3252
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3389
length of database: 76,859,062
effective HSP length: 87
effective length of database: 56,231,710
effective search space used: 6860268620
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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